Best TWAS P=2.3e-24 · Best GWAS P=1.47e-61 conditioned to 1.95e-21
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | HOMEZ | 0.24 | -0.01 | lasso | 4 | -0.01 | 9.6e-01 | 12.328 | -10.2 | 2.3e-24 | -0.50 | 0.06 | 0.29 | TRUE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | SLC22A17 | 0.21 | 0.05 | lasso | 4 | 0.07 | 1.1e-04 | 11.746 | 10.1 | 3.4e-24 | 0.44 | 0.32 | 0.33 | TRUE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CMTM5 | 0.15 | 0.06 | lasso | 4 | 0.05 | 9.0e-03 | 4.712 | -9.5 | 1.5e-21 | -0.48 | 0.02 | 0.24 | TRUE |
| 2 | GTEx | Colon Transverse | RBM23 | 0.31 | 0.05 | lasso | 4 | 0.10 | 2.0e-05 | 0.097 | 6.7 | 2.4e-11 | 0.23 | 0.16 | 0.05 | TRUE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | THTPA | 0.12 | 0.01 | blup | 62 | 0.04 | 1.2e-02 | 5.501 | -6.1 | 9.1e-10 | -0.06 | 0.02 | 0.22 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | NGDN | 0.05 | 0.03 | enet | 9 | 0.02 | 5.9e-03 | 2.381 | 5.8 | 5.0e-09 | 0.24 | 0.02 | 0.15 | TRUE |
| 6 | METSIM | Adipose | PPP1R3E | 0.07 | 0.00 | blup | 462 | 0.02 | 5.3e-04 | 4.554 | 9.0 | 2.6e-19 | 0.44 | 0.04 | 0.59 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | RBM23 | 0.28 | 0.00 | enet | 32 | 0.04 | 1.7e-02 | -0.135 | 7.6 | 2.3e-14 | 0.32 | 0.05 | 0.44 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | HAUS4 | 0.37 | 0.24 | enet | 22 | 0.24 | 3.7e-09 | -0.587 | -5.3 | 1.0e-07 | -0.19 | 0.99 | 0.00 | FALSE |