Hub : Genes

HOMEZ

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.240	0.075	0.0022	-0.008	NA	-0.008	NA	-0.008	0.91000	NA	0.99000	NA	0.9600
2	TCGA	Pheochromocytoma and Paraganglioma	0.187	0.093	0.0032	0.009	0.047	0.040	NA	0.017	0.13000	6.0e-03	0.01000	NA	0.0660
3	TCGA	Thyroid Carcinoma	0.082	0.034	0.0002	0.041	0.041	0.020	NA	0.028	0.00007	7.6e-05	0.00440	NA	0.0009
4	TCGA	Uterine Corpus Endometrial Carcinoma	0.267	0.110	0.0052	0.006	0.096	0.100	NA	0.068	0.21000	1.3e-03	0.00097	NA	0.0060

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	2.0	-1.4	0.9	1.0	0.4
Bipolar Disorder or Schizophrenia	0.3	0.7	1.9	-0.4	0.8	1.4	0.5
Depressed Affect (Nagel 2018)	0.9	1.8	3.2	-1.5	1.4	0.3	1.8
Depression (Nagel 2018)	0.2	0.4	0.9	-0.9	0.1	-0.6	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.2	0.0	0.1	0.8	1.1
Neuroticism (Nagel 2018)	1.4	3.4	5.8	-1.5	1.8	1.4	2.4
Schizophrenia (2018)	0.2	0.4	1.1	0.6	0.2	1.0	0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	0.8	-0.1	0.1	-1.2
Worry (Nagel 2018)	1.1	2.2	3.6	-1.3	1.9	1.5	1.1
Alzheimer’s Disease (in mother)	0.9	1.1	1.6	0.1	-1.1	-1.3	-1.3
Alzheimer’s Disease (in father)	1.1	1.2	1.9	0.8	-1.4	-1.2	0.8
Alzheimer’s Disease (including proxy)	1.2	1.8	3.6	0.8	-1.7	-1.9	0.1
Crohns Disease (2017)	0.1	0.2	0.8	-0.9	-0.3	-0.2	0.0
Irritable Bowel Disease (IBD)	0.2	0.4	1.5	-1.2	-0.0	-0.3	0.2
Ulcerative Colitis (UC)	0.3	0.6	2.0	-1.4	0.6	-0.3	0.2
Major Depression (MDD)	3.1	3.8	8.0	0.5	-1.2	-2.3	-2.8
Reaction Time	0.3	0.7	2.1	0.5	-0.0	-0.6	-1.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.3	-0.7	-0.3	0.2	1.8
Breast Cancer	0.5	1.1	2.1	1.3	0.9	-0.1	-1.4
Ovarian Cancer	0.2	0.3	0.7	-0.3	0.9	0.5	0.5
Prostate Cancer	1.6	2.3	5.2	-2.3	0.5	-0.9	1.7
Age at First Birth	1.1	1.6	2.5	1.0	1.5	1.6	-0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	1.9	3.9	0.0	2.0	1.9	-0.0
Coronary Artery Disease (CAD)	1.1	1.3	4.6	2.2	-0.7	-0.2	-0.2
Crohns Disease (2012)	0.2	0.3	0.7	0.4	-0.8	-0.4	-0.3
Mean Putamen Volume	5.7	6.5	12.0	-1.3	3.5	3.3	1.2
Fasting Glucose	1.4	1.6	2.9	-1.6	1.7	1.1	-0.0
HbA1C	0.2	0.2	0.6	-0.1	-0.4	-0.0	-0.7
HDL Cholesterol	0.4	0.7	2.6	1.6	-0.4	-0.1	-0.4
LDL Cholesterol	0.7	1.1	2.4	1.0	-1.0	-1.6	-0.4
Lupus	1.2	1.8	2.8	0.1	-1.7	-1.7	1.3
Neuroticism (2016)	0.0	0.0	0.1	0.3	0.2	-0.0	0.1
Primary Biliary Cirrhosis	0.5	0.7	1.4	-0.3	-1.1	-1.2	0.5
Rheumatoid Arthritis	0.3	0.4	0.6	0.7	-0.5	0.8	0.4
Schizophrenia (2014)	0.0	0.1	0.1	0.2	0.2	0.4	-0.1
Triglycerides	0.5	0.8	1.1	0.7	-1.1	-1.0	0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	-0.3	0.8	0.2	0.7
Ulcerative Colitis	0.8	1.1	1.9	-1.4	-0.2	-0.9	1.3
Blood Eosinophil Count	1.6	12.7	16.8	2.8	-4.1	-4.1	-3.1
Blood Platelet Count	1.6	18.8	46.2	3.0	-6.8	-4.4	0.7
Blood Red Count	0.2	2.1	7.9	-0.6	0.5	-0.1	2.8
Blood White Count	2.4	17.6	39.3	0.7	-5.4	-6.3	1.0
Heel T-Score	0.6	4.5	7.5	0.9	-2.7	-2.7	-1.6
BMI	1.0	5.6	10.9	-0.2	2.5	2.3	3.3
Height	3.5	67.3	136.9	-3.5	11.7	10.9	1.2
Waist Hip Ratio (WHR)	0.7	3.3	5.6	-1.9	-2.0	-2.4	-0.0
Systolic Blood Pressure	2.5	12.6	22.4	4.7	-3.6	-3.5	-1.6
Smoking Status	1.7	4.2	8.3	-0.2	-2.8	-2.9	-0.6
Allergy or Eczema	0.6	1.6	2.9	0.8	-1.2	-1.2	-1.7
Cardiovascular Disease	0.8	2.5	7.4	2.7	-1.1	-0.9	-0.7
Hypothyroidism (self reported)	0.3	0.7	1.6	0.4	0.2	1.0	1.2
Respiratory disease	0.2	0.4	0.8	0.1	-0.5	-0.9	-0.7
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.6	-1.6	1.6	0.9	-0.4
Lung FEV1/FVC ratio	0.7	3.4	12.0	3.5	-1.1	-0.6	-0.2
Lung FVC	0.2	1.2	4.5	0.2	0.4	-0.3	-2.1
Neuroticism	1.8	4.3	7.1	-2.2	2.7	1.6	1.6
Chronotype (morning person)	0.7	1.7	3.5	-1.4	-0.8	-1.9	-0.8
Hair Pigment	0.1	2.9	5.7	-1.7	1.0	1.3	2.4
Tanning	0.2	2.9	5.6	-0.1	-2.3	-2.4	-0.5
Hand grip strength (left)	1.8	4.7	9.6	-0.8	3.1	2.9	0.4
Number of treatments/medications taken	1.7	3.0	5.1	2.2	-1.4	-1.9	-1.2
Average weekly spirits intake	1.6	2.0	2.8	-1.4	1.7	1.6	0.8
Sensitivity / hurt feelings	0.8	1.4	4.0	-0.9	0.4	0.8	2.0
Frequency of depressed mood in last 2 weeks	1.6	2.2	7.1	-2.7	1.0	0.6	0.4
Hearing difficulty/problems: Yes	0.7	1.1	2.2	0.9	-1.2	-0.5	1.5
Relative age of first facial hair	1.6	3.2	7.6	-0.1	2.2	2.8	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.0	0.3	0.6	0.5	1.4
Ever used hormone-replacement therapy (HRT)	1.1	1.3	2.4	0.8	-1.6	-1.5	0.2
Ever had hysterectomy (womb removed)	1.1	1.3	5.1	-2.3	0.0	-0.2	-0.1
Systolic blood pressure, automated reading	3.1	9.0	17.4	4.2	-3.3	-2.5	1.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.8	-0.9	0.5	0.1	-1.4
Angina	1.8	2.3	5.9	-0.3	-0.7	-1.7	-2.4
Medication for hormone replacement therapy	0.1	0.1	0.5	-0.7	0.1	0.1	0.3
Vitamin and mineral supplements	1.9	2.6	6.9	0.8	-1.4	-0.9	-2.6
Supplements: Zinc	0.2	0.2	0.3	0.3	-0.6	-0.6	-0.4
Medication: Co-codamol	1.1	1.3	3.1	1.4	0.3	0.2	-1.8
Medication: Metformin	0.7	0.9	1.9	-1.0	1.4	0.8	-0.6
Diabetes (father)	0.2	0.3	1.0	1.0	-0.2	0.0	0.0
Diabetes (mother)	0.7	0.8	1.8	-0.8	-0.2	-1.3	-1.0
Severe depression (siblings)	1.7	1.8	3.4	-1.2	-1.5	-1.8	0.6
Pack years adult smoking proportion	0.8	1.2	2.6	-1.2	-1.0	-1.6	-0.1
Impedance of leg (right)	0.9	4.2	8.2	-0.6	-2.1	-2.0	-2.9
Leg fat-free mass (left)	3.2	16.9	31.4	-1.8	5.6	4.9	3.0
Trunk fat percentage	0.7	2.8	5.9	-1.4	1.7	0.7	2.4
Hand grip strength (right)	2.4	6.6	12.4	-1.4	3.5	3.4	-0.4
Townsend deprivation index at recruitment	0.6	0.8	2.5	-0.0	-0.8	-1.6	-0.4
Current tobacco smoking	2.0	3.3	5.6	-1.2	-1.8	-2.4	-1.7
Average weekly fortified wine intake	0.3	0.3	0.8	0.3	0.9	0.7	0.0
Maternal smoking around birth	0.9	1.4	4.1	-2.0	-0.0	-1.0	0.5
Fed-up feelings	0.7	1.3	2.2	-0.9	1.3	0.6	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.6	-0.9	-0.3	-1.0	1.6
Relative age voice broke	0.2	0.4	0.7	-0.3	0.9	0.6	0.4
Taking other prescription medications	3.8	5.9	7.2	2.7	-2.2	-2.4	-2.3
Age when periods started (menarche)	1.0	2.4	8.8	0.4	0.7	0.4	-3.0
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.1	0.8	-1.4	-1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.8	0.5	-1.3	-0.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	0.6	-1.2	-0.7	0.4
Qualifications: CSEs or equivalent	1.9	2.5	6.2	-2.5	1.1	0.9	1.4
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-0.6	-0.8	-0.1	1.1
High blood pressure	0.8	2.3	6.9	2.6	-1.1	-1.0	0.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.6	0.5	-1.1	-0.9	-1.3
Multivitamins +/- minerals	2.4	3.1	5.4	-2.0	1.2	1.2	2.3
Stomach or abdominal pain in last month	0.3	0.4	1.1	-1.1	0.2	-0.0	-0.6
Supplements: Glucosamine	0.8	1.1	1.9	1.3	0.7	1.4	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.6	0.1	0.8	-0.5	-0.4
Medication: Atenolol	0.3	0.4	1.2	-0.2	0.0	-0.5	1.1
Medication: Levothyroxine sodium	0.1	0.1	0.5	0.2	-0.7	-0.1	0.1
Sitting height	1.3	9.4	21.7	-1.0	4.7	3.8	0.3
Chronic bronchitis/emphysema (father)	1.4	1.6	3.0	-0.8	-1.5	-1.7	-0.9
High blood pressure (mother)	0.6	0.8	2.2	1.5	0.4	0.8	-0.2
Body mass index (BMI)	0.6	2.5	9.3	0.5	0.5	0.4	3.0
Impedance of leg (left)	0.9	4.2	6.7	-0.9	-2.1	-2.2	-2.6
Leg predicted mass (left)	3.2	17.1	31.7	-1.8	5.6	4.9	3.1
Trunk fat mass	1.4	6.0	8.9	-1.4	3.0	2.1	2.9
Waist circumference	0.6	2.2	5.3	-0.5	1.5	1.0	2.3
Number of incorrect matches in round	0.6	1.1	2.2	0.7	-0.2	-1.2	-1.5
Past tobacco smoking	1.9	3.5	8.0	-1.2	2.8	2.2	-0.0
Alcohol usually taken with meals	0.3	0.5	1.0	-1.0	-0.1	0.7	0.7
Nervous feelings	0.2	0.4	1.3	-1.2	0.6	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.5	-0.7	0.1	-0.1	0.2
Hearing difficulty/problems with background noise	1.2	1.9	4.4	0.8	-2.1	-1.6	0.1
Hair/balding pattern: Pattern 2	0.8	1.0	1.5	-0.9	1.0	0.8	-1.2
Had menopause	2.5	3.1	4.7	2.1	-2.2	-1.2	1.3
Had other major operations	1.7	2.0	4.7	0.0	-0.8	-1.7	-2.2
Forced vital capacity (FVC)	1.9	7.2	16.0	-2.0	4.0	3.0	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.9	-1.4	-1.1	-0.7	-0.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.8	0.4	-0.9	-1.7	1.0
Qualifications: None of the above	0.3	0.6	1.7	1.3	0.3	-0.2	-0.8
Financial difficulties in last 2 years	0.2	0.3	0.7	0.5	-0.8	-0.6	0.0
Mouth/teeth dental problems	0.4	0.6	1.6	0.7	-0.4	-0.3	-1.3
Heart attack	0.8	1.0	3.1	-1.8	0.3	-0.8	0.5
Allergy	0.7	1.6	3.0	-0.6	1.1	1.7	1.4
Pain all over the body in last month	1.1	1.2	3.1	-1.2	-0.1	-0.1	1.8
Diabetes (self-reported)	0.6	0.9	1.4	-0.9	1.1	1.2	0.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.8	1.1	-1.1	-0.8	-1.7
Medication: Ramipril	0.7	0.9	1.6	-1.0	1.3	0.4	-0.8
Medication: Simvastatin	0.6	0.9	1.5	1.2	-1.0	-0.9	-0.5
Fluid intelligence score	1.0	2.0	3.1	-1.8	1.3	0.8	1.6
Illnesses of siblings	1.1	1.6	2.8	-1.4	1.7	0.9	0.8
Neuroticism score	2.1	4.4	6.8	-2.6	2.6	1.8	1.1
Weight	2.1	10.3	16.3	-1.1	4.0	3.5	3.3
Impedance of arm (right)	0.7	3.3	7.5	-2.7	1.8	1.3	-1.1
Arm fat percentage (right)	0.6	2.5	6.9	-0.2	1.4	1.2	2.6
Trunk fat-free mass	2.8	15.9	30.4	-0.9	5.3	5.5	2.1
Hip circumference	1.5	6.6	11.6	0.1	3.4	3.0	2.3
Time employed in main current job	0.6	0.6	1.6	0.9	0.2	1.3	-0.2
Alcohol intake versus 10 years previously	0.5	0.8	1.7	0.1	0.3	-1.3	-1.2
Father’s age at death	0.2	0.2	0.4	-0.6	0.3	0.6	0.2
Worrier / anxious feelings	1.0	1.9	3.1	-1.4	1.7	1.0	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.7	-0.0	-0.5	-0.1
Falls in the last year	0.6	0.9	1.9	-1.4	0.8	-0.9	0.4
Hair/balding pattern: Pattern 3	0.6	0.8	2.0	1.4	-0.5	-0.8	-0.7
Number of live births	0.7	1.1	2.6	-0.2	-1.2	-1.6	-0.3
Forced expiratory volume in 1-second (FEV1)	1.4	4.7	11.2	-0.8	3.4	2.6	0.4
Pulse rate	19.5	33.0	104.0	-10.2	4.1	2.3	2.3
Happiness	0.9	1.1	2.4	-1.5	-0.9	-0.9	-0.7
Noisy workplace	0.9	1.1	2.3	0.5	-1.5	-1.4	0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.3	-1.1	1.1	1.1	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.7	0.2	-0.4	-1.0	-1.3
Mouth/teeth dental problems: Dentures	0.4	0.7	2.3	0.3	-0.4	-0.6	-1.5
Asthma	1.1	2.2	4.5	0.5	-0.9	-1.8	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	-0.4	0.0	-1.1	-0.7
Medication: Cholesterol lowering	0.8	1.2	1.8	1.0	-1.2	-1.3	-0.9
Depression (self-reported)	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.4
Medication: Lansoprazole	0.9	1.0	3.0	0.3	-0.5	-0.9	-1.7
Prospective memory result	0.6	0.8	1.3	0.2	-1.2	-0.7	-1.1
Lung cancer (father)	1.0	1.1	1.7	1.1	-1.1	-1.3	-0.5
Illnesses of mother	1.0	1.2	2.6	-1.6	1.0	0.4	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	10.7	-0.5	3.3	3.0	0.6
Pulse wave Arterial Stiffness index	0.5	0.6	1.0	0.9	-1.0	-0.6	-0.2
Impedance of arm (left)	0.5	2.2	6.6	-2.6	1.1	0.6	-0.8
Arm fat mass (right)	1.2	5.0	10.0	-0.3	2.3	2.2	3.2
Trunk predicted mass	2.8	16.2	31.4	-0.9	5.3	5.6	2.1
Standing height	3.3	32.5	63.9	-3.6	8.0	7.2	1.0
Length of working week for main job	0.7	0.8	2.3	-1.5	0.2	0.4	0.9
Exposure to tobacco smoke at home	1.4	1.6	3.6	-0.4	-0.1	-1.9	-1.6
Breastfed as a baby	0.4	0.5	1.2	-0.2	-0.9	-0.2	1.1
Tense / ‘highly strung’	0.4	0.7	0.9	-0.8	0.8	0.7	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.4	0.2	-2.0	-2.3	1.3
Hair/balding pattern: Pattern 4	0.7	1.6	4.6	2.1	-1.3	0.1	0.5
Birth weight of first child	0.7	1.3	3.0	-0.5	1.7	1.3	-0.2
Peak expiratory flow (PEF)	0.6	1.5	2.8	-0.8	1.3	0.8	1.7
Pulse wave reflection index	4.9	6.0	18.2	4.3	-1.9	-0.8	-1.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	-0.3	0.9	0.8	1.2
Loud music exposure frequency	0.3	0.3	0.8	0.3	-0.5	-0.9	0.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	1.7	-1.3	0.9	1.0	-0.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	5.7	-0.7	0.1	0.3	2.4
Blood clot in the leg (DVT)	1.0	1.3	4.9	2.2	0.3	0.1	-0.4
Medication: Paracetamol	1.2	2.0	5.4	0.2	-0.1	-1.5	-2.3
Headache pain in last month	1.8	3.1	4.2	-2.1	0.6	-2.0	-2.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.7	-1.9	1.0	0.9	1.1
Glaucoma (self-reported)	1.0	1.1	2.7	-0.5	-1.1	-1.6	-0.5
Gout (self-reported)	0.3	0.4	1.4	0.2	0.1	-0.5	-1.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.2	0.7	0.5	1.5	1.2
Medication: Amlodipine	0.8	1.1	3.8	0.2	-0.3	-0.6	-1.9
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.0	1.7	-0.8	-0.7	-1.2
Birth weight	2.2	4.9	11.3	-1.7	3.4	2.3	0.4
Chronic bronchitis/emphysema (mother)	1.7	1.9	3.2	-1.4	-1.6	-1.8	0.2
High blood pressure (siblings)	2.3	3.4	4.7	1.8	-2.2	-2.0	-1.3
Forced vital capacity (FVC), Best measure	2.0	7.2	15.8	-1.7	4.0	3.2	-0.4
Body fat percentage	0.5	2.2	6.3	-1.2	1.0	0.2	2.5
Leg fat percentage (right)	0.4	1.5	3.8	-0.1	-0.9	-1.2	2.0
Arm fat-free mass (right)	1.7	8.6	13.6	-0.6	3.7	3.5	2.8
Exposure to tobacco smoke outside home	2.0	2.7	3.9	-1.5	2.0	1.1	-1.9
Comparative body size at age 10	0.5	1.4	3.7	-1.0	1.0	-0.1	1.9
Number of full brothers	0.2	0.2	0.4	-0.7	-0.2	0.6	0.5
Worry too long after embarrassment	2.5	4.3	8.9	-0.3	2.1	3.0	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.9	1.7	-0.3	-0.6	-0.8
Wheeze or whistling in the chest in last year	1.1	1.9	5.2	0.3	-1.1	-2.3	-1.1
Number of children fathered	0.4	0.5	0.7	-0.8	0.8	0.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.5	-0.2	1.2	1.1	0.6
Age at first live birth	1.5	2.7	4.0	-1.5	2.0	1.9	1.0
Pulse wave peak to peak time	1.0	1.2	2.2	-0.8	1.5	1.3	0.2
Health satisfaction	0.2	0.2	0.3	-0.4	-0.6	-0.5	0.1
Shortness of breath walking on level ground	1.2	1.4	2.8	-1.7	0.1	-0.1	1.7
Qualifications: College or University degree	0.4	1.2	3.3	1.2	0.2	1.8	0.1
Eye problems/disorders: None of the above	1.4	1.6	2.6	-1.1	1.6	1.5	-0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-0.9	0.8	-0.3	1.0
Emphysema/chronic bronchitis	1.6	1.8	4.9	-1.3	-0.4	-0.8	-2.2
Medication for pain relief, constipation, heartburn	1.2	2.0	4.5	0.3	0.6	2.1	1.8
Neck or shoulder pain in last month	1.3	1.9	3.9	-1.3	-1.3	-2.0	-0.0
Medication: Blood pressure	1.4	2.5	4.3	2.1	-1.3	-1.5	-1.2
Angina (self-reported)	1.7	2.3	5.7	-0.4	-0.6	-1.7	-2.4
Migraine (self-reported)	0.9	1.1	3.1	-0.4	-0.5	-0.9	-1.8
Medication: Ibuprofen	0.6	0.7	1.3	0.4	0.3	-1.1	-1.2
Medication: Allopurinol	1.0	1.3	4.4	0.5	0.6	-0.6	-2.1
Medication: Omeprazole	1.3	1.6	2.4	-0.2	-1.3	-1.4	1.6
Medication: Seretide 50 evohaler	1.1	1.3	2.8	-0.4	-1.1	-0.9	-1.7
Mean time to correctly identify matches	0.1	0.3	0.4	0.6	-0.4	-0.0	-0.7
Heart disease (mother)	1.0	1.3	4.7	-0.3	-0.2	-0.6	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.2	-1.5	0.3	0.2	-1.2
Whole body fat mass	1.3	5.3	8.7	-1.4	2.6	1.9	3.0
Leg fat mass (right)	0.7	2.6	6.5	-0.7	1.5	1.0	2.5
Arm predicted mass (right)	1.8	9.1	14.7	-0.8	3.8	3.7	2.8
Pulse rate, automated reading	28.6	92.4	309.8	-17.6	5.4	2.9	4.6
Alcohol intake frequency.	0.7	1.6	3.8	-1.9	1.5	-0.1	0.4
Comparative height size at age 10	2.7	15.0	22.8	-3.4	4.8	4.7	2.0
Number of full sisters	0.3	0.3	1.2	-1.1	-0.0	-0.2	0.1
Suffer from ‘nerves’	0.7	1.0	3.5	-1.9	0.5	0.3	0.5
Overall health rating	0.7	1.4	4.1	-0.5	-1.1	-2.0	-0.4
Chest pain or discomfort	1.6	2.3	7.7	-2.8	0.3	0.2	1.2
Had major operations	1.6	1.8	3.4	-0.1	-0.8	-1.8	-1.9
Age at last live birth	0.8	1.2	3.3	0.1	0.9	1.8	0.7
Family relationship satisfaction	0.4	0.5	1.8	-1.3	-0.2	-0.6	-0.0
Leg pain on walking	0.2	0.2	0.4	-0.2	-0.6	-0.3	-0.7
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.4	7.3	-1.1	-2.3	-2.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.7	-1.7	-0.5	-0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.9	-0.6	1.4	1.3	0.4
Medication: Aspirin	0.1	0.2	0.4	-0.1	0.6	-0.1	-0.5
Supplements: Vitamin C	1.0	1.2	2.7	1.2	0.5	0.6	1.6
Knee pain experienced in last month	0.9	1.4	3.8	1.9	-1.3	-0.2	-0.2
Hypertension (Self-reported)	0.9	2.6	7.3	2.7	-1.2	-1.2	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	4.2	1.6	-1.6	-2.1	-0.8
Illnesses of father: Heart disease	1.8	2.5	4.4	1.1	-2.0	-2.1	0.8
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.6	-0.6	-0.6	-0.9
Smoking status: Previous	1.2	1.8	3.1	1.1	-1.8	-1.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	4.3	8.9	16.9	-2.5	4.1	3.5	0.1
Whole body fat-free mass	3.0	17.0	30.2	-1.4	5.5	5.3	2.7
Leg fat-free mass (right)	3.2	17.3	31.1	-1.9	5.6	4.9	3.2
Arm fat percentage (left)	0.6	2.6	8.2	-0.3	1.1	0.8	2.9
Average weekly red wine intake	2.0	3.0	7.1	2.7	-1.6	-0.4	-1.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.9	1.4	-1.0	-1.2	0.2
Mood swings	1.0	1.9	3.9	-2.0	1.5	0.2	1.2
Loneliness, isolation	2.6	3.6	8.0	-2.8	1.7	0.8	1.6
Long-standing illness, disability or infirmity	0.2	0.3	0.5	-0.5	0.6	0.5	0.7
Ever had bowel cancer screening	0.3	0.3	0.9	-0.6	0.9	0.2	0.3
Diabetes diagnosed by doctor	0.6	1.0	1.9	-1.2	1.4	0.8	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.5	-0.6	1.2	0.6	-0.5
Friendships satisfaction	0.7	0.9	2.6	-1.6	0.7	0.7	-0.3
Qualifications: nursing, teaching	1.4	2.2	6.9	-2.6	-0.1	0.7	1.1
Commuting to job workplace: Walk	0.8	0.9	2.7	0.9	-1.6	-0.3	0.0
Eye problems/disorders: Cataract	1.3	1.5	2.1	-0.9	-1.3	-1.4	1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.9	-0.9	0.8	0.7	0.7
Medication for cholesterol	0.2	0.3	0.8	-0.4	0.9	0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.0	-0.8	0.5	-0.6	-2.0
Back pain experienced in last month	0.2	0.2	0.9	0.1	-0.0	-0.9	0.2
Mineral and other dietary supplements	1.2	1.7	3.1	-0.8	-1.8	-1.6	0.3
Breast cancer (self-reported)	0.3	0.3	0.8	-0.7	-0.1	0.0	-0.9
Asthma (self-reported)	1.0	2.0	3.4	0.8	-1.1	-1.8	-1.7
Osteoporosis (self-reported)	1.5	1.9	5.2	2.3	0.7	0.9	-1.0
Osteoarthritis (self-reported)	0.8	1.0	2.9	1.7	-1.0	-0.2	0.2
Medication: Aspirin	0.2	0.2	0.7	-0.3	0.8	-0.2	-0.4
Medication: Gliclazide	1.5	1.7	2.5	-1.0	1.6	1.4	-1.1
Illnesses of father: None of the above (group 1)	1.3	1.6	3.1	-0.8	1.8	1.4	-0.8
Smoking status: Current	2.2	3.5	5.6	-0.8	-1.9	-2.4	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	2.9	1.7	1.2	1.7	-0.0
Whole body water mass	2.9	16.7	30.2	-1.4	5.5	5.2	2.6
Leg predicted mass (right)	3.3	17.8	32.4	-1.9	5.7	5.0	3.2
Arm fat mass (left)	1.3	5.2	10.3	-0.5	2.4	2.2	3.2
Number of self-reported non-cancer illnesses	1.6	2.8	7.2	1.1	-1.4	-2.7	-0.7
Average weekly champagne plus white wine intake	0.7	0.9	1.2	-0.9	0.9	0.9	1.1
Miserableness	0.7	1.2	2.9	-1.7	0.5	-0.4	1.3
Guilty feelings	1.8	2.7	5.3	-2.3	2.0	1.0	0.5
Wears glasses or contact lenses	0.2	0.2	0.7	0.4	-0.8	-0.4	-0.1
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.2	-0.7	-0.3	0.4
Hearing aid user	0.1	0.1	0.3	0.0	-0.0	-0.5	-0.6
Mother’s age at death	0.8	1.0	1.6	0.9	-1.0	-1.3	0.8
Financial situation satisfaction	0.2	0.3	0.7	-0.9	0.4	0.5	0.0
Tinnitus: Yes, now most or all of the time	1.5	1.8	2.9	0.2	1.5	1.4	1.7
Commuting to job workplace: Public transport	1.9	2.3	8.4	2.9	-0.3	-0.4	0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.4	-1.0	-0.9	-0.0
Medication: Blood pressure	0.3	0.5	1.3	1.1	-0.5	-0.3	-0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.1	-0.2	-0.3	-1.1	-0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.0	0.6	1.1	1.4	0.2
High cholesterol (Self-reported)	1.9	3.4	5.7	2.4	-2.3	-1.6	0.1
Medication: Bendroflumethiazide	1.5	2.2	5.6	0.7	-1.7	-2.4	-0.0
Medication: Paracetamol	1.6	2.5	6.1	1.4	-0.4	-1.3	-2.5
Medication: Lisinopril	0.6	0.8	1.5	1.2	0.1	0.3	-1.2
Medication: Atorvastatin	0.1	0.1	0.2	-0.3	0.3	-0.5	-0.3
Illnesses of father: High blood pressure	0.4	0.5	1.0	1.0	-0.7	-0.5	-0.7
Alcohol drinker status: Never	2.0	2.4	4.1	-1.4	2.0	1.8	0.6
Ever smoked	1.9	3.4	6.1	0.5	-2.5	-2.3	-1.4
Basal metabolic rate	2.9	16.2	28.8	-1.4	5.4	5.0	2.9
Leg fat percentage (left)	0.5	1.7	4.7	-0.1	-0.9	-1.2	2.2
Arm fat-free mass (left)	1.9	9.7	16.5	-0.8	4.1	3.9	2.6
Number of operations (self-reported)	1.2	1.8	4.8	-1.1	-0.3	-1.0	-2.2
Average weekly beer plus cider intake	0.6	0.8	2.3	-0.1	-1.5	-0.9	-0.4
Irritability	0.6	1.0	2.1	-1.4	0.9	0.9	0.6
Risk taking	0.7	1.0	1.8	-0.1	1.3	0.8	-1.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	0.3	0.4	1.1	-0.7
Fractured/broken bones in last 5 years	0.6	0.8	2.4	-0.9	1.5	0.3	0.1
Age started oral contraceptive pill	0.8	1.0	2.7	1.7	0.1	0.6	0.8
Diastolic blood pressure, automated reading	0.9	2.7	5.9	-2.4	0.3	-0.2	2.2
Ever depressed for a whole week	0.2	0.2	0.6	-0.8	0.6	-0.2	-0.1
Unable to work because of sickness or disability	0.4	0.5	0.9	-0.9	0.2	-0.7	0.7
Commuting to job workplace: Cycle	1.2	1.4	2.4	1.2	-1.5	-1.3	-0.5
Myopia	1.3	1.8	3.9	-2.0	1.7	0.1	-0.6
Vascular/heart problems diagnosed by doctor	0.8	2.1	6.4	-2.5	1.1	1.0	0.3
Cholesterol lowering medication	0.4	0.5	0.9	0.1	-0.7	-0.9	0.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.3	1.0	-0.9	-0.8	1.5
Pain experienced in last month	0.3	0.6	2.0	0.5	0.4	1.4	-0.1
Supplements: Calcium	1.5	1.7	6.0	2.4	-0.3	-0.4	0.7
Basal cell carcinoma (self-reported)	1.7	2.1	3.4	1.1	1.5	1.9	-1.2
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.6	-1.9	0.4	-0.7	0.6
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.0	2.0	0.1	-0.2	-1.2
Heart disease (siblings)	0.5	0.6	0.9	-0.5	-0.9	-0.7	-0.8
Alcohol drinker status: Previous	0.9	1.0	2.6	-0.8	-0.4	-1.6	-0.7
Pack years of smoking	1.2	1.7	4.3	-0.8	-1.3	-2.1	-0.4
Impedance of whole body	0.5	2.8	5.2	-2.3	-0.4	-1.1	-2.1
Leg fat mass (left)	0.7	2.8	7.1	-0.6	1.6	1.1	2.7
Arm predicted mass (left)	2.0	10.1	17.6	-0.6	4.2	4.1	2.4