[Hub]/) : Traits : Pulse rate : ←

chr22:38,192,452-39,859,169

Best TWAS P=2.58e-08 · Best GWAS P=4.38e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Esophagus Muscularis	RP3-508I15.9	0.13	0.12	enet	23	0.10	1.1e-06	-5.4	5.6	2.6e-08	-0.97	0.05	0.95	TRUE
24	GTEx	Nerve Tibial	TOMM22	0.11	0.08	lasso	4	0.08	5.2e-06	-5.3	5.6	2.6e-08	-0.93	0.02	0.97	FALSE
29	GTEx	Skin Sun Exposed Lower leg	TOMM22	0.07	0.07	lasso	4	0.07	3.2e-06	-5.5	5.5	4.4e-08	-1.00	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TOMM22	0.07	0.03	blup	43	0.04	8.8e-03	-5.5	5.5	4.7e-08	-0.99	0.02	0.84	FALSE
34	GTEx	Uterus	RP3-508I15.9	0.15	0.09	lasso	4	0.09	8.2e-03	-5.5	5.5	4.8e-08	-1.00	0.03	0.85	FALSE
26	GTEx	Pancreas	TOMM22	0.10	0.08	lasso	6	0.09	1.4e-04	-5.5	5.5	4.9e-08	-0.99	0.02	0.97	FALSE
12	GTEx	Breast Mammary Tissue (Female)	RP3-508I15.9	0.13	0.12	lasso	3	0.07	3.6e-03	-5.4	5.4	5.3e-08	-0.91	0.04	0.72	FALSE
7	GTEx	Artery Coronary	CBY1	0.26	0.20	lasso	4	0.22	8.3e-08	-5.4	5.4	5.8e-08	-0.99	0.04	0.96	FALSE
11	GTEx	Breast Mammary Tissue	CBY1	0.11	0.08	lasso	6	0.07	1.5e-04	-5.3	5.4	5.8e-08	-0.99	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	TOMM22	0.11	0.02	lasso	5	0.01	6.5e-02	-5.5	5.4	6.6e-08	-0.98	0.02	0.82	FALSE
8	GTEx	Artery Tibial	CBY1	0.23	0.28	lasso	6	0.26	1.9e-20	-5.4	5.4	6.8e-08	-0.99	0.02	0.98	FALSE
10	GTEx	Artery Tibial	RP3-508I15.9	0.18	0.21	lasso	8	0.21	1.3e-16	-5.4	5.4	7.1e-08	-0.99	0.03	0.97	FALSE
21	GTEx	Lung	RP3-508I15.9	0.10	0.15	lasso	2	0.14	1.5e-10	-5.4	5.4	7.4e-08	-0.99	0.02	0.98	FALSE
33	GTEx	Testis	RP3-508I15.9	0.13	0.11	lasso	4	0.13	1.6e-06	-5.3	5.4	8.2e-08	-0.96	0.04	0.96	FALSE
19	GTEx	Esophagus Muscularis	CBY1	0.15	0.16	lasso	2	0.14	1.2e-08	-5.4	5.4	8.4e-08	-0.99	0.02	0.98	FALSE
18	GTEx	Esophagus Mucosa	RP3-508I15.19	0.08	0.06	lasso	1	0.06	1.1e-04	-5.3	5.3	9.1e-08	-0.95	0.06	0.94	FALSE
28	GTEx	Skin Sun Exposed Lower leg	CBY1	0.11	0.13	enet	22	0.12	2.1e-10	-5.4	5.3	9.8e-08	-0.96	0.01	0.98	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOMM22	0.02	0.01	enet	11	0.01	1.1e-03	-5.4	5.3	9.8e-08	-0.91	0.01	0.97	FALSE
3	GTEx	Adipose Subcutaneous	RP3-508I15.9	0.16	0.23	lasso	3	0.22	3.5e-18	-5.4	5.3	1.0e-07	-0.99	0.02	0.98	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	RP3-508I15.9	0.12	0.12	lasso	2	0.09	3.2e-04	-5.3	5.3	1.0e-07	-0.95	0.03	0.91	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	GTPBP1	0.02	0.04	lasso	3	0.03	2.5e-04	-5.3	5.3	1.0e-07	-0.95	0.02	0.95	FALSE
4	GTEx	Adipose Visceral Omentum	CBY1	0.15	0.22	lasso	4	0.21	3.4e-11	-5.4	5.3	1.1e-07	-0.99	0.02	0.98	FALSE
22	GTEx	Nerve Tibial	DDX17	0.10	0.09	lasso	5	0.07	1.2e-05	-5.3	-5.3	1.1e-07	0.97	0.02	0.98	FALSE
35	GTEx	Vagina	RP3-508I15.9	0.29	0.21	lasso	4	0.14	3.8e-04	-5.4	5.3	1.2e-07	-0.95	0.05	0.90	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TOMM22	0.15	0.26	lasso	7	0.27	4.0e-33	-5.5	5.3	1.3e-07	-0.99	0.01	0.99	FALSE
30	GTEx	Skin Sun Exposed Lower leg	RP3-508I15.14	0.06	0.06	lasso	3	0.04	3.3e-04	-5.3	5.3	1.3e-07	-0.95	0.03	0.96	FALSE
6	GTEx	Artery Aorta	CBY1	0.30	0.24	lasso	5	0.25	4.8e-14	-4.8	5.3	1.4e-07	-0.98	0.08	0.92	FALSE
16	GTEx	Esophagus Mucosa	SUN2	0.12	0.14	lasso	3	0.14	1.3e-09	-5.3	5.2	1.8e-07	-0.94	0.06	0.94	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	TOMM22	0.02	0.02	blup	43	0.02	1.7e-03	-5.5	5.2	1.8e-07	-0.99	0.02	0.91	FALSE
23	GTEx	Nerve Tibial	CBY1	0.22	0.32	lasso	11	0.34	1.0e-24	-5.4	5.2	1.9e-07	-0.98	0.07	0.93	FALSE
5	GTEx	Adipose Visceral Omentum	RP3-508I15.9	0.15	0.14	lasso	4	0.14	1.5e-07	-5.4	5.2	2.0e-07	-0.99	0.04	0.96	FALSE
32	GTEx	Testis	GTPBP1	0.13	0.12	lasso	8	0.17	4.3e-08	-5.3	5.2	2.0e-07	-0.92	0.03	0.96	FALSE
17	GTEx	Esophagus Mucosa	RP3-508I15.14	0.11	0.08	lasso	7	0.07	2.1e-05	-4.8	5.2	2.2e-07	-0.97	0.10	0.90	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	TOMM22	0.13	0.11	lasso	6	0.11	7.9e-07	-5.3	5.2	2.3e-07	-0.97	0.03	0.97	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	TOMM22	0.06	0.04	lasso	3	0.04	1.1e-04	-5.5	5.2	2.4e-07	-0.98	0.02	0.98	FALSE
13	GTEx	Colon Sigmoid	RP3-508I15.9	0.10	0.11	lasso	15	0.09	5.8e-04	-5.4	5.2	2.5e-07	-0.98	0.05	0.93	FALSE
25	GTEx	Nerve Tibial	RP3-508I15.9	0.26	0.38	lasso	10	0.40	5.6e-30	-4.9	5.1	2.7e-07	-0.98	0.11	0.88	FALSE
31	GTEx	Skin Sun Exposed Lower leg	RP3-508I15.9	0.22	0.28	lasso	10	0.30	1.6e-25	-4.8	5.1	2.8e-07	-0.97	0.11	0.88	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	JOSD1	0.05	0.02	blup	50	0.04	2.7e-03	-5.0	5.1	2.9e-07	-0.98	0.03	0.87	FALSE
15	GTEx	Esophagus Mucosa	JOSD1	0.16	0.24	lasso	2	0.25	1.3e-16	-5.3	5.1	3.0e-07	-0.95	0.04	0.96	FALSE
9	GTEx	Artery Tibial	TOMM22	0.07	0.10	lasso	3	0.09	8.2e-08	-4.8	5.1	3.1e-07	-0.90	0.09	0.91	FALSE