Hub : Genes

GTPBP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1290	0.0440	2.8e-05	0.115	NA	0.081	NA	0.172	8.6e-06	NA	0.00019	NA	4.3e-08
2	TCGA	Brain Lower Grade Glioma	0.0237	0.0158	2.3e-03	0.022	0.024	0.014	NA	0.021	1.3e-03	0.00086	0.00930	NA	1.8e-03
3	TCGA	Lung Adenocarcinoma	0.0220	0.0129	8.1e-04	0.037	0.023	0.016	NA	0.028	3.3e-05	0.00089	0.00460	NA	2.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pulse rate, automated reading	22.8	73.6	84.4	8.9	7.6	9.2
Heel T-Score	19.4	154.0	166.4	11.7	12.9	12.6
Pulse rate	15.1	25.5	28.3	5.2	4.6	5.3
Ever used hormone-replacement therapy (HRT)	10.1	12.9	14.4	-3.4	-3.6	-3.8
Medication for hormone replacement therapy	9.5	10.6	12.5	-3.5	-2.8	-3.4
Diverticular disease/diverticulitis (self-reported)	9.1	10.8	16.1	-3.1	-2.6	-4.0
Heel bone mineral density (BMD) T-score, automated (right)	8.2	18.8	26.1	3.7	5.1	4.1
Alcohol intake versus 10 years previously	8.1	12.1	13.4	-3.1	-3.7	-3.6
Alcohol intake frequency.	7.7	17.9	20.2	-3.8	-4.5	-4.4
Depressed Affect (Nagel 2018)	7.5	15.7	18.5	-3.7	-3.9	-4.3
Heel bone mineral density (BMD) T-score, automated (left)	7.5	17.0	22.0	3.4	4.7	4.2
Rheumatoid Arthritis	6.7	9.3	14.5	-2.7	-3.8	-2.4
Fractured/broken bones in last 5 years	6.5	8.4	10.4	-2.5	-2.9	-3.2
Number of children fathered	6.2	7.0	11.4	2.4	1.9	3.4
Overall health rating	6.2	13.3	16.6	-3.3	-3.6	-4.1
Financial difficulties in last 2 years	6.1	8.2	10.2	-2.5	-2.9	-3.2
Triglycerides	6.0	9.8	12.6	-3.6	-2.8	-3.1
Length of working week for main job	5.9	6.5	7.1	-2.5	-2.7	-2.5
Neuroticism (Nagel 2018)	5.6	13.3	13.8	-3.6	-3.6	-3.7
Suffer from ‘nerves’	5.6	8.8	10.2	-3.0	-2.7	-3.2
Alzheimer’s Disease (in mother)	5.5	6.5	8.6	2.7	2.9	2.0
Long-standing illness, disability or infirmity	5.4	8.2	9.0	-3.0	-2.6	-3.0
Happiness	5.1	6.2	6.6	-2.4	-2.5	-2.6
Hip circumference	5.0	21.5	25.7	-4.2	-4.6	-5.1
Commuting to job workplace: Car/motor vehicle	4.6	5.3	5.9	2.3	2.2	2.4
Back pain experienced in last month	4.6	6.8	8.5	-2.0	-2.9	-2.8
Pack years adult smoking proportion	4.0	6.2	10.0	-2.0	-3.2	-2.1
Hand grip strength (right)	3.9	10.6	11.7	3.2	3.2	3.4
Crohns Disease (2017)	3.7	8.1	8.7	2.7	3.0	2.8
Illness, injury, bereavement, stress in last 2 years	3.7	4.5	4.6	2.1	2.1	2.1
Hand grip strength (left)	3.6	9.6	13.2	2.8	3.6	2.8
Townsend deprivation index at recruitment	3.6	5.1	6.4	-2.2	-2.0	-2.5
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.6	6.2	-2.4	-2.2	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	3.6	3.9	4.1	-1.9	-2.0	-2.0
Number of self-reported non-cancer illnesses	3.6	6.2	7.5	-2.4	-2.4	-2.7
Number of operations (self-reported)	3.6	5.4	7.7	-1.8	-2.8	-2.2
Hypothyroidism (self reported)	3.3	7.6	10.2	-2.7	-3.2	-2.4
Had other major operations	3.3	4.0	6.4	-1.3	-2.5	-2.0
Hypothyroidism/myxoedema (self-reported)	3.3	6.5	7.0	-2.6	-2.6	-2.3
Mood swings	3.3	5.9	7.0	-2.1	-2.6	-2.5
Alzheimer’s Disease (including proxy)	3.2	4.6	5.6	2.4	2.2	1.9
Qualifications: CSEs or equivalent	3.2	4.2	4.9	-1.9	-2.0	-2.2
Medication: Amlodipine	3.2	4.5	5.3	2.0	2.3	2.1
Leg pain on walking	3.2	4.0	6.1	-1.4	-2.0	-2.5
Handedness (chirality/laterality): Left-handed	3.2	3.9	5.5	1.5	2.3	1.9
Medication: Paracetamol	3.2	4.9	5.6	-1.9	-2.3	-2.4
Crohns Disease (2012)	3.1	5.0	6.3	2.0	2.5	2.2
Gout (self-reported)	3.1	4.3	4.9	2.0	2.0	2.2
Mouth/teeth dental problems: Mouth ulcers	3.1	4.9	5.8	-2.4	-1.9	-2.3
Ever taken oral contraceptive pill	3.1	3.4	4.9	-2.2	-2.0	-1.1
Primary Biliary Cirrhosis	3.0	4.3	4.8	-1.9	-2.2	-2.1
Loneliness, isolation	3.0	4.2	6.2	-1.8	-2.5	-1.8
Coronary Artery Disease (CAD)	2.9	3.5	6.1	1.8	1.0	2.5
Pulse wave peak to peak time	2.9	3.4	4.1	-2.0	-1.6	-1.9
Medication for cholesterol	2.9	4.4	4.9	2.2	2.2	1.8
Allergy	2.8	6.5	7.2	2.7	2.7	2.3
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	6.0	-1.6	-1.2	-2.4
Chest pain or discomfort	2.6	3.7	5.0	-1.4	-2.0	-2.2
Medication: Levothyroxine sodium	2.5	4.3	5.6	-1.9	-2.4	-1.9
Waist Hip Ratio (WHR)	2.4	10.7	11.7	3.2	3.2	3.4
Neuroticism	2.4	5.7	7.6	-2.2	-2.2	-2.8
Chronotype (morning person)	2.4	5.6	6.7	-2.6	-2.2	-2.3
Family relationship satisfaction	2.4	3.0	4.5	-1.7	-1.3	-2.1
Smoking status: Previous	2.4	3.5	4.3	2.1	1.8	1.7
Blood Platelet Count	2.3	26.2	42.0	-4.3	-4.2	-6.5
Friendships satisfaction	2.3	2.8	3.5	-1.9	-1.5	-1.7
Commuting to job workplace: Walk	2.3	2.5	3.7	-1.9	-1.1	-1.6
Illnesses of father: Heart disease	2.2	3.1	3.3	1.7	1.7	1.8
Medication: Gliclazide	2.2	2.5	3.2	-1.8	-1.5	-1.4
Ever depressed for a whole week	2.2	2.7	3.2	-1.6	-1.8	-1.5
Worry (Nagel 2018)	2.1	4.5	5.1	-2.3	-1.9	-2.2
HDL Cholesterol	2.1	3.5	4.5	2.1	1.7	1.8
Taking other prescription medications	2.1	3.2	4.5	-1.8	-1.3	-2.1
Medication: Ramipril	2.1	2.7	3.4	1.8	1.3	1.7
Birth weight of first child	2.1	3.7	4.9	-1.7	-1.9	-2.2
Age at last live birth	2.1	3.0	3.9	-2.0	-1.4	-1.8
Pack years of smoking	2.1	3.1	5.9	-1.3	-2.4	-1.3
Depression (Nagel 2018)	2.0	3.1	3.6	-1.9	-1.4	-1.9
Fed-up feelings	2.0	3.7	4.7	-1.5	-2.0	-2.2
Trunk fat mass	2.0	8.5	9.8	-2.5	-3.1	-3.1
Weight	2.0	9.7	11.3	-2.7	-3.3	-3.4
Time employed in main current job	2.0	2.3	3.0	1.7	1.0	1.7
Pulse wave Arterial Stiffness index	2.0	2.3	2.7	1.6	1.3	1.6
Wheeze or whistling in the chest in last year	2.0	3.6	4.5	-1.6	-2.1	-1.9
Heart disease (siblings)	2.0	2.5	3.3	1.8	1.3	1.5
Number of treatments/medications taken	1.9	3.4	4.1	-1.7	-1.8	-2.0
Average weekly spirits intake	1.9	2.3	3.5	1.2	1.9	1.4
Vitamin and mineral supplements	1.9	2.5	3.3	1.4	1.8	1.5
Qualifications: nursing, teaching	1.9	2.9	4.1	-2.0	-1.6	-1.5
Heart attack/myocardial infarction (self-reported)	1.9	2.4	2.9	1.4	1.6	1.7
Neuroticism score	1.8	3.8	4.5	-1.6	-2.1	-2.1
Hair/balding pattern: Pattern 4	1.8	4.4	6.0	-1.8	-2.5	-2.0
Health satisfaction	1.8	2.3	3.2	-1.0	-1.6	-1.8
Arm fat percentage (left)	1.8	7.1	9.3	-2.2	-2.7	-3.0
Medication: Lisinopril	1.8	2.4	2.4	-1.5	-1.5	-1.6
Hayfever, allergic rhinitis or eczema	1.7	3.7	4.5	-2.1	-2.1	-1.5
Leg predicted mass (left)	1.7	8.9	10.2	-2.6	-3.1	-3.2
Qualifications: A levels/AS levels or equivalent	1.7	3.7	4.8	-2.2	-1.3	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	3.1	-1.8	-1.2	-1.1
Lung cancer (father)	1.7	2.0	2.6	-1.1	-1.5	-1.6
Leg fat-free mass (right)	1.7	8.8	10.6	-2.6	-3.1	-3.2
Basal cell carcinoma (self-reported)	1.7	2.0	2.9	-1.2	-1.7	-1.3
Diabetes (mother)	1.6	2.0	3.6	-1.3	-0.8	-1.9
Leg fat-free mass (left)	1.6	8.7	9.9	-2.6	-3.1	-3.2
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	2.1	1.5	1.3	1.3
Leg predicted mass (right)	1.6	8.3	10.0	-2.5	-3.0	-3.2
Ever had prostate specific antigen (PSA) test	1.6	1.8	2.5	1.5	0.9	1.6
Age started oral contraceptive pill	1.6	2.0	2.8	1.4	1.7	1.2
Relative age of first facial hair	1.5	3.1	3.6	-1.8	-1.6	-1.9
Arm fat mass (right)	1.5	6.1	8.5	-2.0	-2.4	-2.9
Medication: Paracetamol	1.5	2.6	3.2	-1.2	-1.7	-1.8
Whole body fat mass	1.5	6.3	7.9	-2.0	-2.6	-2.8
Unable to work because of sickness or disability	1.5	2.0	2.3	-1.4	-1.3	-1.5
Major Depression (MDD)	1.4	1.7	2.5	-1.2	-1.6	-1.0
Multivitamins +/- minerals	1.4	1.7	2.0	-1.4	-1.2	-1.3
Stomach or abdominal pain in last month	1.4	1.8	2.7	-1.3	-1.0	-1.7
High blood pressure (mother)	1.4	2.0	2.9	-1.7	-1.4	-1.0
Past tobacco smoking	1.4	2.6	3.5	-1.9	-1.6	-1.3
Heart attack	1.4	1.8	2.1	1.1	1.4	1.5
Arm fat percentage (right)	1.4	5.7	7.6	-1.9	-2.4	-2.8
Worry too long after embarrassment	1.4	2.3	2.8	-1.3	-1.7	-1.5
Medication: Ibuprofen	1.4	1.7	2.1	-1.5	-1.1	-1.3
Wears glasses or contact lenses	1.4	1.6	2.3	1.5	0.9	1.3
Illnesses of father: High blood pressure	1.4	1.7	2.4	-1.6	-1.1	-1.2
Basal metabolic rate	1.4	8.0	9.2	-2.5	-2.9	-3.0
Height	1.3	25.8	30.9	-5.5	-5.6	-4.0
Trunk fat percentage	1.3	5.3	6.2	-1.9	-2.5	-2.5
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	1.9	-1.3	-0.9	-1.4
Chronic bronchitis/emphysema (father)	1.3	1.5	2.1	1.3	1.4	0.8
Waist circumference	1.3	4.6	6.5	-1.5	-2.2	-2.5
Standing height	1.3	13.1	16.3	-3.8	-4.0	-3.0
Comparative height size at age 10	1.3	7.4	8.3	-2.5	-2.9	-2.7
Arm fat mass (left)	1.3	5.5	7.9	-1.8	-2.3	-2.8
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.2	-1.1	-1.3	-1.5
Irritable Bowel Disease (IBD)	1.2	2.9	3.1	1.7	1.8	1.7
Ever had hysterectomy (womb removed)	1.2	1.4	1.6	-1.3	-1.2	-1.0
Supplements: Zinc	1.2	1.4	1.5	-1.2	-1.1	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.6	-1.2	-0.9	-1.6
Worrier / anxious feelings	1.2	2.3	2.3	-1.5	-1.5	-1.5
Noisy workplace	1.2	1.5	2.5	-1.2	-0.6	-1.6
Peak expiratory flow (PEF)	1.2	2.7	3.5	1.6	1.4	1.9
Headache pain in last month	1.2	2.1	3.9	-1.2	-1.0	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	1.5	1.2	1.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	2.8	-1.7	-1.5	-1.6
Alcohol drinker status: Never	1.2	1.4	1.6	-1.3	-1.1	-1.2
Ever smoked	1.2	2.1	2.8	1.7	1.4	1.2
Alzheimer’s Disease (in father)	1.1	1.2	1.6	-1.1	-1.3	-0.9
Hair/balding pattern: Pattern 2	1.1	1.4	2.8	-1.1	0.2	-1.7
Forced vital capacity (FVC)	1.1	4.1	5.7	-2.4	-1.7	-1.9
Body fat percentage	1.1	4.4	5.4	-1.7	-2.2	-2.3
Smoking status: Current	1.1	1.7	2.9	-0.8	-1.2	-1.7
Whole body water mass	1.1	6.3	7.5	-2.2	-2.5	-2.7
Miserableness	1.1	1.9	2.5	-0.9	-1.6	-1.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.1	-1.3	-0.4	-1.4
Commuting to job workplace: Public transport	1.1	1.3	1.5	-1.0	-1.2	-1.2
Diastolic blood pressure, automated reading	1.1	3.5	4.1	2.0	1.8	1.8
Pain experienced in last month	1.1	1.8	3.1	0.7	1.3	1.8
Schizophrenia vs Biploar Disorder	1.0	1.3	1.8	1.2	1.4	0.7
Schizophrenia (2014)	1.0	2.2	3.1	1.5	1.8	1.1
Allergy or Eczema	1.0	2.6	3.3	-1.7	-1.8	-1.2
Current tobacco smoking	1.0	1.6	3.0	-0.8	-1.1	-1.7
Average weekly fortified wine intake	1.0	1.2	3.0	-0.4	-1.7	-0.7
Serious illness, injury or assault to yourself	1.0	1.3	2.6	-0.2	-1.6	-1.1
Medication: Atenolol	1.0	1.2	1.6	1.1	1.0	1.3
Trunk fat-free mass	1.0	5.6	6.5	-2.2	-2.4	-2.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	4.4	-2.1	-1.9	-1.6
Mouth/teeth dental problems: Dentures	1.0	1.7	2.5	1.6	1.6	0.4
Whole body fat-free mass	1.0	5.9	7.1	-2.1	-2.5	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.7	0.9	1.0	1.3
Osteoporosis (self-reported)	1.0	1.2	1.6	-1.2	-1.3	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.2	-1.0	-1.5	-0.7
Alcohol drinker status: Previous	1.0	1.1	2.1	-0.7	-1.4	-0.9
HbA1C	0.9	1.0	1.9	-0.8	-1.4	-0.7
Medication: Metformin	0.9	1.2	1.3	-1.0	-1.1	-1.2
Trunk predicted mass	0.9	5.2	6.0	-2.1	-2.3	-2.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.3	-1.1	-0.9	-1.1
Shortness of breath walking on level ground	0.9	1.0	2.0	-0.5	-1.4	-0.9
Knee pain experienced in last month	0.9	1.4	2.8	-0.5	-1.1	-1.7
Illnesses of father: None of the above (group 1)	0.9	1.2	1.7	-0.7	-1.3	-1.1
Hearing aid user	0.9	1.0	1.7	-1.3	-0.6	-0.9
Number of incorrect matches in round	0.8	1.3	2.1	-1.1	-1.4	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.2	-1.1	-0.7	-1.1
Medication for pain relief, constipation, heartburn	0.8	1.4	2.0	1.1	1.4	1.1
Leg fat mass (right)	0.8	3.0	4.4	-1.3	-1.7	-2.1
Arm predicted mass (right)	0.8	3.9	4.8	-1.7	-2.0	-2.2
Osteoarthritis (self-reported)	0.8	1.0	1.5	-1.1	-0.6	-1.2
Leg fat mass (left)	0.8	3.2	4.5	-1.3	-1.8	-2.1
Breast Cancer	0.7	1.8	2.1	-1.3	-1.2	-1.4
Medication: Co-codamol	0.7	0.8	1.4	-0.7	-1.2	-0.8
Had menopause	0.7	0.9	1.2	-0.6	-1.0	-1.1
Diabetes (self-reported)	0.7	1.1	1.3	-1.1	-1.0	-1.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.4	1.2	0.9	0.9
Falls in the last year	0.7	0.9	2.1	-0.7	0.1	-1.5
Number of live births	0.7	1.0	1.4	-1.2	-1.1	-0.6
Impedance of arm (left)	0.7	3.3	4.3	-2.1	-2.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.9	-0.8	-0.9	-1.4
Eye problems/disorders: None of the above	0.7	0.8	1.7	0.3	1.3	0.8
Had major operations	0.7	0.8	1.3	-0.9	-0.7	-1.1
Respiratory disease	0.6	1.2	1.6	-1.3	-0.9	-1.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	-0.7	-0.7	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.1	2.9	-0.1	-0.5	-1.7
Medication: Cholesterol lowering	0.6	0.9	1.1	1.0	0.8	1.0
Loud music exposure frequency	0.6	0.7	1.0	-0.9	0.5	-1.0
Arm fat-free mass (right)	0.6	2.9	3.7	-1.3	-1.8	-1.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.4	-0.7	-0.4	-1.2
Medication: Omeprazole	0.6	0.7	1.2	-0.7	-1.1	-0.7
Mineral and other dietary supplements	0.6	0.8	1.1	0.8	1.0	0.7
Myopia	0.6	0.8	2.3	0.3	1.5	0.2
Cholesterol lowering medication	0.6	0.8	1.5	-0.8	-1.2	-0.6
Schizophrenia (2018)	0.5	0.9	1.4	1.0	1.2	0.6
Prostate Cancer	0.5	0.7	1.3	0.3	-1.1	0.9
Age at First Birth	0.5	0.7	1.1	-0.9	-0.3	-1.0
Mean Putamen Volume	0.5	0.6	0.9	-0.7	-0.6	-1.0
Cardiovascular Disease	0.5	1.7	3.6	-1.0	-1.9	-0.7
Tanning	0.5	5.9	6.8	2.6	2.2	2.5
Sensitivity / hurt feelings	0.5	0.9	1.5	-0.9	-1.2	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	0.9	-0.8	-1.0	-0.6
Diabetes (father)	0.5	0.6	1.2	-1.1	0.2	-0.8
High blood pressure	0.5	1.5	2.3	-0.9	-1.5	-1.1
Body mass index (BMI)	0.5	2.3	4.2	-0.9	-1.4	-2.0
Pain all over the body in last month	0.5	0.5	0.8	-0.9	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.1	-1.5	-1.3	-0.8
Age at first live birth	0.5	1.0	1.7	-1.3	-0.5	-1.0
Asthma (self-reported)	0.5	0.9	1.1	-1.0	-0.7	-1.1
Arm fat-free mass (left)	0.5	2.4	3.1	-1.3	-1.6	-1.8
Average weekly beer plus cider intake	0.5	0.7	1.1	1.1	0.4	0.9
Irritability	0.5	0.8	1.2	-0.8	-1.1	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.4	-1.1	-1.5	-0.7
Bipolar Disorder (2011)	0.4	0.3	1.0	0.0	0.0	1.0
Severe depression (siblings)	0.4	0.4	1.0	-0.1	1.0	0.5
Maternal smoking around birth	0.4	0.5	0.9	-0.2	-0.8	-0.9
Impedance of arm (right)	0.4	1.9	2.9	-1.7	-1.5	-0.8
Birth weight	0.4	0.9	1.7	-0.9	-0.1	-1.3
High blood pressure (siblings)	0.4	0.6	0.7	0.9	0.8	0.8
Exposure to tobacco smoke outside home	0.4	0.5	0.7	-0.7	-0.6	-0.9
Number of full sisters	0.4	0.5	0.8	-0.9	-0.7	-0.4
Supplements: Vitamin C	0.4	0.5	0.8	-0.5	-0.7	-0.9
Average weekly red wine intake	0.4	0.5	1.1	0.3	1.0	0.6
Eye problems/disorders: Cataract	0.4	0.5	1.3	-0.2	-1.1	-0.4
Medication: Bendroflumethiazide	0.4	0.6	1.0	-0.5	-1.0	-0.6
Supplements: Calcium	0.4	0.5	1.0	0.3	1.0	0.6
Arm predicted mass (left)	0.4	2.0	2.6	-1.1	-1.4	-1.6
Reaction Time	0.3	0.5	1.2	0.1	-1.1	-0.5
Fasting Glucose	0.3	0.4	0.6	-0.8	-0.3	-0.7
Blood White Count	0.3	2.3	4.9	-0.7	-1.2	-2.2
Impedance of leg (right)	0.3	1.4	2.8	0.4	1.2	1.7
Impedance of leg (left)	0.3	1.6	3.0	0.6	1.2	1.7
Alcohol usually taken with meals	0.3	0.4	0.7	-0.9	-0.4	-0.7
Asthma	0.3	0.7	0.9	-0.9	-0.7	-0.8
Prospective memory result	0.3	0.4	1.0	-0.4	0.0	-1.0
Pulse wave reflection index	0.3	0.4	0.9	-0.5	-0.5	-0.9
Glaucoma (self-reported)	0.3	0.3	0.4	-0.5	-0.5	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.1	2.1	-1.4	-0.8	-0.7
Leg fat percentage (right)	0.3	0.9	1.4	-0.5	-1.0	-1.2
Comparative body size at age 10	0.3	0.9	1.8	1.0	1.3	0.0
Emphysema/chronic bronchitis	0.3	0.3	0.5	-0.2	-0.7	-0.7
Medication: Blood pressure	0.3	0.6	0.8	0.8	0.6	0.9
Heart disease (mother)	0.3	0.4	0.6	-0.4	-0.8	-0.6
Ever had bowel cancer screening	0.3	0.3	0.5	-0.5	-0.4	-0.7
Average weekly champagne plus white wine intake	0.3	0.5	0.8	0.7	0.3	0.9
Medication: Blood pressure	0.3	0.6	0.7	-0.7	-0.8	-0.9
Leg fat percentage (left)	0.3	0.9	1.6	-0.4	-1.0	-1.2
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	0.7	0.8	0.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	-0.9	-0.7	-0.0
Lupus	0.2	0.3	0.6	0.1	0.8	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.3	0.2	-0.7
Blood Eosinophil Count	0.2	1.6	3.6	-0.4	-1.0	-1.9
BMI	0.2	1.1	2.3	-0.2	-0.9	-1.5
Lung FEV1/FVC ratio	0.2	1.1	3.3	0.0	-1.8	-0.2
Supplements: Glucosamine	0.2	0.2	0.3	0.6	-0.6	0.1
Nervous feelings	0.2	0.5	0.6	-0.5	-0.7	-0.7
Tense / ‘highly strung’	0.2	0.3	0.7	0.4	0.3	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.7	0.0	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.6	-0.6	0.2
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.0	0.8	-0.5
Number of full brothers	0.2	0.3	0.6	-0.5	-0.2	-0.8
Medication: Allopurinol	0.2	0.2	0.5	0.4	0.3	0.7
Medication: Seretide 50 evohaler	0.2	0.2	0.2	-0.4	0.4	-0.5
Mean time to correctly identify matches	0.2	0.4	1.2	1.1	-0.3	0.3
Hypertension (Self-reported)	0.2	0.6	1.1	-0.5	-1.1	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.0	0.5	-0.6
Diabetes diagnosed by doctor	0.2	0.4	0.7	-0.5	-0.4	-0.8
Guilty feelings	0.2	0.3	0.8	-0.4	-0.2	-0.9
Medication: Atorvastatin	0.2	0.2	0.5	-0.3	-0.7	0.0
Risk taking	0.2	0.3	0.5	0.1	0.5	0.7
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.2	0.8	-0.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.2	0.2	1.1	0.6
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.5	0.2	0.4
Ovarian Cancer	0.1	0.1	0.3	-0.2	0.3	-0.5
Neuroticism (2016)	0.1	0.1	0.3	-0.2	-0.1	-0.5
Blood Red Count	0.1	1.3	2.5	1.6	0.8	0.9
Systolic Blood Pressure	0.1	0.5	0.8	0.9	0.2	0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.3	0.1	-0.4
Hearing difficulty/problems: Yes	0.1	0.1	0.1	0.1	0.4	-0.4
Systolic blood pressure, automated reading	0.1	0.4	0.7	0.8	0.4	0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.1	-0.5	0.4
Angina	0.1	0.1	0.1	0.1	-0.3	0.4
Relative age voice broke	0.1	0.1	0.2	-0.2	-0.4	-0.2
Age when periods started (menarche)	0.1	0.2	0.3	-0.5	-0.5	0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.0	-0.0	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.4	0.2	-0.5
Qualifications: None of the above	0.1	0.1	0.3	0.6	0.3	-0.2
Mouth/teeth dental problems	0.1	0.2	0.2	-0.4	-0.4	0.4
Fluid intelligence score	0.1	0.1	0.2	-0.4	-0.3	0.4
Father’s age at death	0.1	0.1	0.2	-0.1	0.1	0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.3	-0.4	0.3
Depression (self-reported)	0.1	0.1	0.3	-0.1	-0.3	-0.5
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	-0.1	-0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.1	-0.4	0.1
Breastfed as a baby	0.1	0.1	0.2	-0.1	-0.4	0.5
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.2	-0.2	-0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.4	-0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	0.4	0.3	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.1	-0.6	-0.4
Qualifications: College or University degree	0.1	0.2	0.3	-0.5	-0.1	0.4
Neck or shoulder pain in last month	0.1	0.1	0.2	0.3	0.1	-0.5
Angina (self-reported)	0.1	0.1	0.3	0.3	-0.1	0.5
Migraine (self-reported)	0.1	0.1	0.1	0.2	-0.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.3	0.0	0.5
Breast cancer (self-reported)	0.1	0.2	0.3	-0.5	-0.5	0.2
Medication: Aspirin	0.1	0.1	0.3	-0.0	-0.5	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.3	0.7	0.3
Mother’s age at death	0.1	0.2	0.2	0.5	0.3	0.4
Financial situation satisfaction	0.1	0.1	0.2	-0.0	-0.4	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.2	-0.4	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.2	0.2	-0.5
Impedance of whole body	0.1	0.4	0.8	-0.9	-0.6	0.2
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.1	-0.1	-0.3
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.1	-0.0	-0.3
LDL Cholesterol	0.0	0.0	0.0	-0.0	-0.0	-0.2
Ulcerative Colitis	0.0	0.0	0.1	0.1	-0.3	0.1
Smoking Status	0.0	0.1	0.2	0.3	-0.4	-0.2
Lung FVC	0.0	0.0	0.0	-0.2	0.1	-0.2
Hair Pigment	0.0	0.1	0.1	-0.4	-0.0	0.2
Sitting height	0.0	0.2	0.4	-0.6	-0.2	-0.4
Medication: Simvastatin	0.0	0.0	0.0	0.1	0.1	0.1
Illnesses of siblings	0.0	0.0	0.1	0.0	0.1	0.3
Illnesses of mother	0.0	0.0	0.0	0.1	-0.1	0.1
Medication: Aspirin	0.0	0.0	0.1	0.1	-0.2	0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.1	0.3	-0.0
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	0.2	0.0	-0.1
High cholesterol (Self-reported)	0.0	0.1	0.2	0.0	-0.5	0.1