[Hub]/) : Traits : Hand grip strength (left) :

chr12:14,220,891-16,190,627

Best TWAS P=9.01e-26 · Best GWAS P=4.27e-25 conditioned to 0.0998

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous ARHGDIB 0.10 0.01 enet 27 0.01 3.6e-02 -10.2 8.2 3.4e-16 -0.66 0.04 0.88 FALSE
2 GTEx Artery Aorta ARHGDIB 0.10 0.06 enet 10 0.08 5.4e-05 -9.2 9.8 1.0e-22 -0.86 0.10 0.86 FALSE
3 GTEx Artery Aorta C12orf60 0.16 0.10 lasso 6 0.13 1.4e-07 3.6 6.9 6.2e-12 -0.66 0.07 0.93 FALSE
4 GTEx Artery Tibial ARHGDIB 0.07 0.02 lasso 7 0.02 6.8e-03 -10.2 10.2 3.0e-24 -0.86 0.05 0.91 FALSE
5 GTEx Brain Nucleus accumbens basal ganglia RP11-174G6.5 0.23 0.13 lasso 4 0.11 8.9e-04 -7.2 9.0 2.2e-19 -0.73 0.04 0.83 FALSE
6 GTEx Heart Left Ventricle H2AFJ 0.16 0.07 lasso 8 0.05 1.1e-03 -5.1 -5.2 2.0e-07 0.16 0.90 0.00 FALSE
7 GTEx Nerve Tibial MGP 0.20 0.09 enet 35 0.10 9.7e-08 -10.1 6.8 8.9e-12 -0.74 0.02 0.98 FALSE
8 GTEx Nerve Tibial RERG 0.10 0.01 enet 18 0.01 7.3e-02 -2.6 5.7 1.5e-08 -0.49 0.06 0.56 FALSE
9 GTEx Testis ARHGDIB 0.13 0.02 enet 10 0.06 1.4e-03 -2.6 5.3 1.5e-07 -0.44 0.08 0.64 FALSE
10 GTEx Thyroid MGP 0.11 0.04 enet 12 0.06 2.6e-05 -10.3 9.3 9.9e-21 -0.91 0.02 0.98 FALSE
11 GTEx Thyroid ARHGDIB 0.12 0.03 enet 20 0.02 7.4e-03 -10.1 9.2 3.3e-20 -0.82 0.02 0.96 FALSE
12 GTEx Thyroid C12orf60 0.16 0.10 enet 9 0.12 8.1e-10 3.8 7.4 1.4e-13 -0.62 0.82 0.18 FALSE
13 METSIM Adipose ARHGDIB 0.03 0.00 blup 374 0.01 6.9e-03 3.6 7.3 2.3e-13 -0.50 0.10 0.08 FALSE
14 METSIM Adipose ERP27 0.07 0.04 blup 379 0.06 1.7e-09 -9.2 9.2 3.0e-20 -0.73 0.77 0.23 FALSE
15 METSIM Adipose MGP 0.04 0.04 bslmm 359 0.04 6.2e-07 -10.2 10.5 9.0e-26 -0.93 0.02 0.98 TRUE
16 NTR Blood ARHGDIB 0.01 0.00 blup 377 0.00 5.6e-02 -9.6 10.2 1.7e-24 -0.81 0.06 0.79 FALSE
17 ROSMAP Brain Pre-frontal Cortex WBP11 0.10 0.05 lasso 4 0.06 1.2e-08 -5.3 6.0 2.1e-09 -0.37 1.00 0.00 FALSE
18 YFS Blood ERP27 0.30 0.41 enet 31 0.42 3.1e-152 -9.5 9.7 4.4e-22 -0.83 0.96 0.04 FALSE
19 YFS Blood H2AFJ 0.05 0.02 bslmm 360 0.03 2.9e-10 -5.1 -6.5 1.0e-10 0.44 1.00 0.00 FALSE
20 The Cancer Genome Atlas Bladder Urothelial Carcinoma ERP27 0.07 0.03 enet 17 0.04 1.6e-04 -9.7 9.0 1.4e-19 -0.69 0.22 0.46 FALSE
21 The Cancer Genome Atlas Breast Invasive Carcinoma ERP27 0.04 0.09 lasso 5 0.09 2.8e-17 -9.6 9.8 9.6e-23 -0.89 0.84 0.16 FALSE
22 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ERP27 0.09 0.14 lasso 2 0.12 1.7e-06 -9.6 9.6 7.2e-22 -0.83 0.21 0.78 FALSE
23 The Cancer Genome Atlas Esophageal Carcinoma ERP27 0.10 0.12 blup 75 0.08 1.5e-03 -9.5 9.9 3.5e-23 -0.86 0.05 0.74 FALSE
24 The Cancer Genome Atlas Glioblastoma Multiforme ERP27 0.18 0.07 blup 76 0.11 2.7e-04 -9.2 9.3 1.1e-20 -0.83 0.06 0.76 FALSE
25 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ERP27 0.10 0.18 lasso 6 0.18 1.2e-19 -9.6 10.0 2.2e-23 -0.88 0.82 0.18 FALSE
26 The Cancer Genome Atlas Brain Lower Grade Glioma ERP27 0.07 0.09 blup 73 0.09 4.8e-10 -9.5 9.7 2.1e-22 -0.87 0.35 0.65 FALSE
27 The Cancer Genome Atlas Lung Adenocarcinoma ERP27 0.15 0.28 lasso 6 0.28 8.3e-33 -9.6 9.6 9.1e-22 -0.84 0.90 0.10 FALSE
28 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ERP27 0.17 0.24 enet 13 0.25 6.7e-28 -9.7 10.1 3.9e-24 -0.86 0.81 0.19 FALSE
29 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C12orf60 0.10 0.01 blup 56 0.07 1.6e-05 3.8 7.5 6.3e-14 -0.64 0.02 0.76 FALSE
30 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ERP27 0.04 0.05 enet 12 0.04 1.0e-03 -9.5 9.7 4.7e-22 -0.86 0.15 0.56 FALSE
31 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ERP27 0.14 0.12 lasso 5 0.11 2.9e-05 -9.6 9.6 9.5e-22 -0.85 0.10 0.84 FALSE
32 The Cancer Genome Atlas Prostate Adenocarcinoma ERP27 0.13 0.14 lasso 5 0.13 8.3e-14 -9.5 9.6 5.1e-22 -0.83 0.87 0.13 FALSE
33 The Cancer Genome Atlas Skin Cutaneous Melanoma ERP27 0.13 0.02 blup 74 0.06 1.4e-02 -9.6 9.9 3.1e-23 -0.84 0.03 0.64 FALSE
34 The Cancer Genome Atlas Stomach Adenocarcinoma ERP27 0.07 0.03 blup 76 0.07 1.5e-05 -3.1 8.8 1.8e-18 -0.72 0.08 0.90 FALSE
35 The Cancer Genome Atlas Testicular Germ Cell Tumors ERP27 0.10 0.05 lasso 1 0.08 8.9e-04 -9.6 9.6 1.1e-21 -0.86 0.14 0.68 FALSE
36 The Cancer Genome Atlas Thyroid Carcinoma ERP27 0.37 0.54 enet 18 0.55 2.3e-63 -9.6 9.9 4.0e-23 -0.86 0.84 0.16 FALSE