Best TWAS P=9.01e-26 · Best GWAS P=4.27e-25 conditioned to 0.0998
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ARHGDIB | 0.10 | 0.01 | enet | 27 | 0.01 | 3.6e-02 | -10.2 | 8.2 | 3.4e-16 | -0.66 | 0.04 | 0.88 | FALSE |
| 2 | GTEx | Artery Aorta | ARHGDIB | 0.10 | 0.06 | enet | 10 | 0.08 | 5.4e-05 | -9.2 | 9.8 | 1.0e-22 | -0.86 | 0.10 | 0.86 | FALSE |
| 3 | GTEx | Artery Aorta | C12orf60 | 0.16 | 0.10 | lasso | 6 | 0.13 | 1.4e-07 | 3.6 | 6.9 | 6.2e-12 | -0.66 | 0.07 | 0.93 | FALSE |
| 4 | GTEx | Artery Tibial | ARHGDIB | 0.07 | 0.02 | lasso | 7 | 0.02 | 6.8e-03 | -10.2 | 10.2 | 3.0e-24 | -0.86 | 0.05 | 0.91 | FALSE |
| 5 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-174G6.5 | 0.23 | 0.13 | lasso | 4 | 0.11 | 8.9e-04 | -7.2 | 9.0 | 2.2e-19 | -0.73 | 0.04 | 0.83 | FALSE |
| 6 | GTEx | Heart Left Ventricle | H2AFJ | 0.16 | 0.07 | lasso | 8 | 0.05 | 1.1e-03 | -5.1 | -5.2 | 2.0e-07 | 0.16 | 0.90 | 0.00 | FALSE |
| 7 | GTEx | Nerve Tibial | MGP | 0.20 | 0.09 | enet | 35 | 0.10 | 9.7e-08 | -10.1 | 6.8 | 8.9e-12 | -0.74 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Nerve Tibial | RERG | 0.10 | 0.01 | enet | 18 | 0.01 | 7.3e-02 | -2.6 | 5.7 | 1.5e-08 | -0.49 | 0.06 | 0.56 | FALSE |
| 9 | GTEx | Testis | ARHGDIB | 0.13 | 0.02 | enet | 10 | 0.06 | 1.4e-03 | -2.6 | 5.3 | 1.5e-07 | -0.44 | 0.08 | 0.64 | FALSE |
| 10 | GTEx | Thyroid | MGP | 0.11 | 0.04 | enet | 12 | 0.06 | 2.6e-05 | -10.3 | 9.3 | 9.9e-21 | -0.91 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Thyroid | ARHGDIB | 0.12 | 0.03 | enet | 20 | 0.02 | 7.4e-03 | -10.1 | 9.2 | 3.3e-20 | -0.82 | 0.02 | 0.96 | FALSE |
| 12 | GTEx | Thyroid | C12orf60 | 0.16 | 0.10 | enet | 9 | 0.12 | 8.1e-10 | 3.8 | 7.4 | 1.4e-13 | -0.62 | 0.82 | 0.18 | FALSE |
| 13 | METSIM | Adipose | ARHGDIB | 0.03 | 0.00 | blup | 374 | 0.01 | 6.9e-03 | 3.6 | 7.3 | 2.3e-13 | -0.50 | 0.10 | 0.08 | FALSE |
| 14 | METSIM | Adipose | ERP27 | 0.07 | 0.04 | blup | 379 | 0.06 | 1.7e-09 | -9.2 | 9.2 | 3.0e-20 | -0.73 | 0.77 | 0.23 | FALSE |
| 15 | METSIM | Adipose | MGP | 0.04 | 0.04 | bslmm | 359 | 0.04 | 6.2e-07 | -10.2 | 10.5 | 9.0e-26 | -0.93 | 0.02 | 0.98 | TRUE |
| 16 | NTR | Blood | ARHGDIB | 0.01 | 0.00 | blup | 377 | 0.00 | 5.6e-02 | -9.6 | 10.2 | 1.7e-24 | -0.81 | 0.06 | 0.79 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | WBP11 | 0.10 | 0.05 | lasso | 4 | 0.06 | 1.2e-08 | -5.3 | 6.0 | 2.1e-09 | -0.37 | 1.00 | 0.00 | FALSE |
| 18 | YFS | Blood | ERP27 | 0.30 | 0.41 | enet | 31 | 0.42 | 3.1e-152 | -9.5 | 9.7 | 4.4e-22 | -0.83 | 0.96 | 0.04 | FALSE |
| 19 | YFS | Blood | H2AFJ | 0.05 | 0.02 | bslmm | 360 | 0.03 | 2.9e-10 | -5.1 | -6.5 | 1.0e-10 | 0.44 | 1.00 | 0.00 | FALSE |
| 20 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ERP27 | 0.07 | 0.03 | enet | 17 | 0.04 | 1.6e-04 | -9.7 | 9.0 | 1.4e-19 | -0.69 | 0.22 | 0.46 | FALSE |
| 21 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ERP27 | 0.04 | 0.09 | lasso | 5 | 0.09 | 2.8e-17 | -9.6 | 9.8 | 9.6e-23 | -0.89 | 0.84 | 0.16 | FALSE |
| 22 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ERP27 | 0.09 | 0.14 | lasso | 2 | 0.12 | 1.7e-06 | -9.6 | 9.6 | 7.2e-22 | -0.83 | 0.21 | 0.78 | FALSE |
| 23 | The Cancer Genome Atlas | Esophageal Carcinoma | ERP27 | 0.10 | 0.12 | blup | 75 | 0.08 | 1.5e-03 | -9.5 | 9.9 | 3.5e-23 | -0.86 | 0.05 | 0.74 | FALSE |
| 24 | The Cancer Genome Atlas | Glioblastoma Multiforme | ERP27 | 0.18 | 0.07 | blup | 76 | 0.11 | 2.7e-04 | -9.2 | 9.3 | 1.1e-20 | -0.83 | 0.06 | 0.76 | FALSE |
| 25 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ERP27 | 0.10 | 0.18 | lasso | 6 | 0.18 | 1.2e-19 | -9.6 | 10.0 | 2.2e-23 | -0.88 | 0.82 | 0.18 | FALSE |
| 26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ERP27 | 0.07 | 0.09 | blup | 73 | 0.09 | 4.8e-10 | -9.5 | 9.7 | 2.1e-22 | -0.87 | 0.35 | 0.65 | FALSE |
| 27 | The Cancer Genome Atlas | Lung Adenocarcinoma | ERP27 | 0.15 | 0.28 | lasso | 6 | 0.28 | 8.3e-33 | -9.6 | 9.6 | 9.1e-22 | -0.84 | 0.90 | 0.10 | FALSE |
| 28 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ERP27 | 0.17 | 0.24 | enet | 13 | 0.25 | 6.7e-28 | -9.7 | 10.1 | 3.9e-24 | -0.86 | 0.81 | 0.19 | FALSE |
| 29 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C12orf60 | 0.10 | 0.01 | blup | 56 | 0.07 | 1.6e-05 | 3.8 | 7.5 | 6.3e-14 | -0.64 | 0.02 | 0.76 | FALSE |
| 30 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ERP27 | 0.04 | 0.05 | enet | 12 | 0.04 | 1.0e-03 | -9.5 | 9.7 | 4.7e-22 | -0.86 | 0.15 | 0.56 | FALSE |
| 31 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ERP27 | 0.14 | 0.12 | lasso | 5 | 0.11 | 2.9e-05 | -9.6 | 9.6 | 9.5e-22 | -0.85 | 0.10 | 0.84 | FALSE |
| 32 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ERP27 | 0.13 | 0.14 | lasso | 5 | 0.13 | 8.3e-14 | -9.5 | 9.6 | 5.1e-22 | -0.83 | 0.87 | 0.13 | FALSE |
| 33 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | ERP27 | 0.13 | 0.02 | blup | 74 | 0.06 | 1.4e-02 | -9.6 | 9.9 | 3.1e-23 | -0.84 | 0.03 | 0.64 | FALSE |
| 34 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ERP27 | 0.07 | 0.03 | blup | 76 | 0.07 | 1.5e-05 | -3.1 | 8.8 | 1.8e-18 | -0.72 | 0.08 | 0.90 | FALSE |
| 35 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ERP27 | 0.10 | 0.05 | lasso | 1 | 0.08 | 8.9e-04 | -9.6 | 9.6 | 1.1e-21 | -0.86 | 0.14 | 0.68 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | ERP27 | 0.37 | 0.54 | enet | 18 | 0.55 | 2.3e-63 | -9.6 | 9.9 | 4.0e-23 | -0.86 | 0.84 | 0.16 | FALSE |