[Hub]/) : Traits : Hand grip strength (right) :

chr12:14,220,891-16,190,627

Best TWAS P=7.59e-25 · Best GWAS P=1.04e-21 conditioned to 0.0341

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous ARHGDIB 0.10 0.01 enet 27 0.01 3.6e-02 -9.5 7.8 6.4e-15 -0.67 0.04 0.90 FALSE
2 GTEx Artery Aorta ARHGDIB 0.10 0.06 enet 10 0.08 5.4e-05 -8.8 9.5 1.6e-21 -0.87 0.06 0.92 FALSE
3 GTEx Artery Aorta C12orf60 0.16 0.10 lasso 6 0.13 1.4e-07 3.8 7.0 3.0e-12 -0.64 0.07 0.93 FALSE
4 GTEx Artery Tibial WBP11 0.09 0.06 lasso 2 0.06 3.8e-05 -5.8 5.5 3.2e-08 -0.39 0.91 0.02 FALSE
5 GTEx Artery Tibial ARHGDIB 0.07 0.02 lasso 7 0.02 6.8e-03 -9.6 9.4 6.0e-21 -0.86 0.04 0.92 FALSE
6 GTEx Brain Cortex C12orf60 0.44 0.28 lasso 3 0.29 1.2e-08 4.2 5.2 2.6e-07 -0.36 0.79 0.02 FALSE
7 GTEx Brain Nucleus accumbens basal ganglia RP11-174G6.5 0.23 0.13 lasso 4 0.11 8.9e-04 -7.3 8.8 8.5e-19 -0.73 0.04 0.83 FALSE
8 GTEx Lung MGP 0.11 0.00 enet 19 0.02 2.3e-02 -9.6 5.8 5.0e-09 -0.49 0.04 0.76 FALSE
9 GTEx Muscle Skeletal WBP11 0.08 0.08 lasso 5 0.08 2.4e-08 -5.4 5.2 2.4e-07 -0.36 0.98 0.00 FALSE
10 GTEx Nerve Tibial MGP 0.20 0.09 enet 35 0.10 9.7e-08 -9.5 6.9 4.9e-12 -0.74 0.03 0.97 FALSE
11 GTEx Nerve Tibial RERG 0.10 0.01 enet 18 0.01 7.3e-02 -2.8 5.8 5.6e-09 -0.49 0.06 0.57 FALSE
12 GTEx Testis ARHGDIB 0.13 0.02 enet 10 0.06 1.4e-03 -2.8 5.2 1.9e-07 -0.45 0.09 0.59 FALSE
13 GTEx Thyroid MGP 0.11 0.04 enet 12 0.06 2.6e-05 -9.6 8.5 1.8e-17 -0.91 0.03 0.97 FALSE
14 GTEx Thyroid ARHGDIB 0.12 0.03 enet 20 0.02 7.4e-03 -9.4 8.8 2.2e-18 -0.83 0.03 0.94 FALSE
15 GTEx Thyroid C12orf60 0.16 0.10 enet 9 0.12 8.1e-10 4.2 7.6 3.4e-14 -0.61 0.81 0.19 FALSE
16 METSIM Adipose ARHGDIB 0.03 0.00 blup 374 0.01 6.9e-03 4.3 6.8 1.2e-11 -0.50 0.09 0.09 FALSE
17 METSIM Adipose ERP27 0.07 0.04 blup 379 0.06 1.7e-09 -8.8 9.0 1.9e-19 -0.73 0.16 0.84 FALSE
18 METSIM Adipose MGP 0.04 0.04 bslmm 359 0.04 6.2e-07 -9.6 10.2 2.5e-24 -0.93 0.03 0.97 FALSE
19 NTR Blood ARHGDIB 0.01 0.00 blup 377 0.00 5.6e-02 -9.4 10.3 7.6e-25 -0.81 0.05 0.81 TRUE
20 ROSMAP Brain Pre-frontal Cortex WBP11 0.10 0.05 lasso 4 0.06 1.2e-08 -5.8 6.0 1.5e-09 -0.36 0.99 0.00 FALSE
21 YFS Blood ERP27 0.30 0.41 enet 31 0.42 3.1e-152 -9.1 9.3 1.5e-20 -0.84 0.46 0.54 FALSE
22 YFS Blood H2AFJ 0.05 0.02 bslmm 360 0.03 2.9e-10 -4.6 -6.7 2.5e-11 0.44 1.00 0.00 FALSE
23 The Cancer Genome Atlas Bladder Urothelial Carcinoma ERP27 0.07 0.03 enet 17 0.04 1.6e-04 -9.6 8.9 7.6e-19 -0.69 0.05 0.88 FALSE
24 The Cancer Genome Atlas Breast Invasive Carcinoma ERP27 0.04 0.09 lasso 5 0.09 2.8e-17 -9.4 9.5 1.4e-21 -0.90 0.05 0.95 FALSE
25 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ERP27 0.09 0.14 lasso 2 0.12 1.7e-06 -9.4 9.4 3.3e-21 -0.84 0.03 0.97 FALSE
26 The Cancer Genome Atlas Esophageal Carcinoma ERP27 0.10 0.12 blup 75 0.08 1.5e-03 -9.1 9.9 2.6e-23 -0.87 0.03 0.84 FALSE
27 The Cancer Genome Atlas Glioblastoma Multiforme ERP27 0.18 0.07 blup 76 0.11 2.7e-04 -8.8 9.0 3.0e-19 -0.83 0.05 0.78 FALSE
28 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ERP27 0.10 0.18 lasso 6 0.18 1.2e-19 -9.4 9.6 7.9e-22 -0.89 0.04 0.96 FALSE
29 The Cancer Genome Atlas Brain Lower Grade Glioma ERP27 0.07 0.09 blup 73 0.09 4.8e-10 -9.1 9.3 1.8e-20 -0.88 0.06 0.94 FALSE
30 The Cancer Genome Atlas Lung Adenocarcinoma ERP27 0.15 0.28 lasso 6 0.28 8.3e-33 -9.4 9.4 3.5e-21 -0.85 0.04 0.96 FALSE
31 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ERP27 0.17 0.24 enet 13 0.25 6.7e-28 -9.5 9.9 3.6e-23 -0.87 0.02 0.98 FALSE
32 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C12orf60 0.10 0.01 blup 56 0.07 1.6e-05 4.2 7.2 4.9e-13 -0.63 0.03 0.72 FALSE
33 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ERP27 0.04 0.05 enet 12 0.04 1.0e-03 -9.1 9.2 3.1e-20 -0.87 0.05 0.85 FALSE
34 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ERP27 0.14 0.12 lasso 5 0.11 2.9e-05 -9.4 9.5 2.9e-21 -0.86 0.04 0.94 FALSE
35 The Cancer Genome Atlas Prostate Adenocarcinoma ERP27 0.13 0.14 lasso 5 0.13 8.3e-14 -9.1 9.2 2.7e-20 -0.85 0.04 0.96 FALSE
36 The Cancer Genome Atlas Skin Cutaneous Melanoma ERP27 0.13 0.02 blup 74 0.06 1.4e-02 -9.4 9.9 2.6e-23 -0.84 0.03 0.71 FALSE
37 The Cancer Genome Atlas Stomach Adenocarcinoma ERP27 0.07 0.03 blup 76 0.07 1.5e-05 -4.0 8.6 6.7e-18 -0.73 0.07 0.90 FALSE
38 The Cancer Genome Atlas Testicular Germ Cell Tumors ERP27 0.10 0.05 lasso 1 0.08 8.9e-04 -9.4 9.4 4.8e-21 -0.86 0.04 0.90 FALSE
39 The Cancer Genome Atlas Thyroid Carcinoma C12orf60 0.16 0.16 enet 10 0.18 1.3e-17 4.2 5.3 8.8e-08 -0.32 1.00 0.00 FALSE
40 The Cancer Genome Atlas Thyroid Carcinoma ERP27 0.37 0.54 enet 18 0.55 2.3e-63 -9.4 9.5 2.3e-21 -0.86 0.02 0.98 FALSE