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chr12:14,220,891-16,190,627

Best TWAS P=7.59e-25 · Best GWAS P=1.04e-21 conditioned to 0.0341

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ARHGDIB	0.10	0.01	enet	27	0.01	3.6e-02	-9.5	7.8	6.4e-15	-0.67	0.04	0.90	FALSE
2	GTEx	Artery Aorta	ARHGDIB	0.10	0.06	enet	10	0.08	5.4e-05	-8.8	9.5	1.6e-21	-0.87	0.06	0.92	FALSE
3	GTEx	Artery Aorta	C12orf60	0.16	0.10	lasso	6	0.13	1.4e-07	3.8	7.0	3.0e-12	-0.64	0.07	0.93	FALSE
4	GTEx	Artery Tibial	WBP11	0.09	0.06	lasso	2	0.06	3.8e-05	-5.8	5.5	3.2e-08	-0.39	0.91	0.02	FALSE
5	GTEx	Artery Tibial	ARHGDIB	0.07	0.02	lasso	7	0.02	6.8e-03	-9.6	9.4	6.0e-21	-0.86	0.04	0.92	FALSE
6	GTEx	Brain Cortex	C12orf60	0.44	0.28	lasso	3	0.29	1.2e-08	4.2	5.2	2.6e-07	-0.36	0.79	0.02	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	RP11-174G6.5	0.23	0.13	lasso	4	0.11	8.9e-04	-7.3	8.8	8.5e-19	-0.73	0.04	0.83	FALSE
8	GTEx	Lung	MGP	0.11	0.00	enet	19	0.02	2.3e-02	-9.6	5.8	5.0e-09	-0.49	0.04	0.76	FALSE
9	GTEx	Muscle Skeletal	WBP11	0.08	0.08	lasso	5	0.08	2.4e-08	-5.4	5.2	2.4e-07	-0.36	0.98	0.00	FALSE
10	GTEx	Nerve Tibial	MGP	0.20	0.09	enet	35	0.10	9.7e-08	-9.5	6.9	4.9e-12	-0.74	0.03	0.97	FALSE
11	GTEx	Nerve Tibial	RERG	0.10	0.01	enet	18	0.01	7.3e-02	-2.8	5.8	5.6e-09	-0.49	0.06	0.57	FALSE
12	GTEx	Testis	ARHGDIB	0.13	0.02	enet	10	0.06	1.4e-03	-2.8	5.2	1.9e-07	-0.45	0.09	0.59	FALSE
13	GTEx	Thyroid	MGP	0.11	0.04	enet	12	0.06	2.6e-05	-9.6	8.5	1.8e-17	-0.91	0.03	0.97	FALSE
14	GTEx	Thyroid	ARHGDIB	0.12	0.03	enet	20	0.02	7.4e-03	-9.4	8.8	2.2e-18	-0.83	0.03	0.94	FALSE
15	GTEx	Thyroid	C12orf60	0.16	0.10	enet	9	0.12	8.1e-10	4.2	7.6	3.4e-14	-0.61	0.81	0.19	FALSE
16	METSIM	Adipose	ARHGDIB	0.03	0.00	blup	374	0.01	6.9e-03	4.3	6.8	1.2e-11	-0.50	0.09	0.09	FALSE
17	METSIM	Adipose	ERP27	0.07	0.04	blup	379	0.06	1.7e-09	-8.8	9.0	1.9e-19	-0.73	0.16	0.84	FALSE
18	METSIM	Adipose	MGP	0.04	0.04	bslmm	359	0.04	6.2e-07	-9.6	10.2	2.5e-24	-0.93	0.03	0.97	FALSE
19	NTR	Blood	ARHGDIB	0.01	0.00	blup	377	0.00	5.6e-02	-9.4	10.3	7.6e-25	-0.81	0.05	0.81	TRUE
20	ROSMAP	Brain Pre-frontal Cortex	WBP11	0.10	0.05	lasso	4	0.06	1.2e-08	-5.8	6.0	1.5e-09	-0.36	0.99	0.00	FALSE
21	YFS	Blood	ERP27	0.30	0.41	enet	31	0.42	3.1e-152	-9.1	9.3	1.5e-20	-0.84	0.46	0.54	FALSE
22	YFS	Blood	H2AFJ	0.05	0.02	bslmm	360	0.03	2.9e-10	-4.6	-6.7	2.5e-11	0.44	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ERP27	0.07	0.03	enet	17	0.04	1.6e-04	-9.6	8.9	7.6e-19	-0.69	0.05	0.88	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERP27	0.04	0.09	lasso	5	0.09	2.8e-17	-9.4	9.5	1.4e-21	-0.90	0.05	0.95	FALSE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ERP27	0.09	0.14	lasso	2	0.12	1.7e-06	-9.4	9.4	3.3e-21	-0.84	0.03	0.97	FALSE
26	The Cancer Genome Atlas	Esophageal Carcinoma	ERP27	0.10	0.12	blup	75	0.08	1.5e-03	-9.1	9.9	2.6e-23	-0.87	0.03	0.84	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	ERP27	0.18	0.07	blup	76	0.11	2.7e-04	-8.8	9.0	3.0e-19	-0.83	0.05	0.78	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ERP27	0.10	0.18	lasso	6	0.18	1.2e-19	-9.4	9.6	7.9e-22	-0.89	0.04	0.96	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERP27	0.07	0.09	blup	73	0.09	4.8e-10	-9.1	9.3	1.8e-20	-0.88	0.06	0.94	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	ERP27	0.15	0.28	lasso	6	0.28	8.3e-33	-9.4	9.4	3.5e-21	-0.85	0.04	0.96	FALSE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ERP27	0.17	0.24	enet	13	0.25	6.7e-28	-9.5	9.9	3.6e-23	-0.87	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C12orf60	0.10	0.01	blup	56	0.07	1.6e-05	4.2	7.2	4.9e-13	-0.63	0.03	0.72	FALSE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ERP27	0.04	0.05	enet	12	0.04	1.0e-03	-9.1	9.2	3.1e-20	-0.87	0.05	0.85	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP27	0.14	0.12	lasso	5	0.11	2.9e-05	-9.4	9.5	2.9e-21	-0.86	0.04	0.94	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	ERP27	0.13	0.14	lasso	5	0.13	8.3e-14	-9.1	9.2	2.7e-20	-0.85	0.04	0.96	FALSE
36	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ERP27	0.13	0.02	blup	74	0.06	1.4e-02	-9.4	9.9	2.6e-23	-0.84	0.03	0.71	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	ERP27	0.07	0.03	blup	76	0.07	1.5e-05	-4.0	8.6	6.7e-18	-0.73	0.07	0.90	FALSE
38	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ERP27	0.10	0.05	lasso	1	0.08	8.9e-04	-9.4	9.4	4.8e-21	-0.86	0.04	0.90	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf60	0.16	0.16	enet	10	0.18	1.3e-17	4.2	5.3	8.8e-08	-0.32	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	ERP27	0.37	0.54	enet	18	0.55	2.3e-63	-9.4	9.5	2.3e-21	-0.86	0.02	0.98	FALSE