[Hub]/) : Traits : Waist circumference :

chr11:64,407,419-68,077,666

Best TWAS P=4.29e-12 · Best GWAS P=2.33e-11 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FIBP 0.08 0.11 enet 20 0.12 8.1e-14 5.3 6.2 4.5e-10 -0.06 0.49 0.51 FALSE
2 CommonMind Brain Pre-frontal Cortex SNX32 0.46 0.36 lasso 8 0.39 1.9e-50 5.8 5.5 3.7e-08 -0.04 0.15 0.85 FALSE
3 GTEx Adipose Subcutaneous CTSW 0.30 0.18 lasso 6 0.16 3.9e-13 5.4 -5.4 8.3e-08 0.03 0.49 0.51 FALSE
4 GTEx Adipose Subcutaneous RAD9A 0.43 0.22 lasso 6 0.23 7.1e-19 -6.7 -6.4 1.6e-10 0.97 0.00 1.00 FALSE
5 GTEx Adipose Visceral Omentum CTSW 0.22 0.20 lasso 11 0.19 5.1e-10 5.4 -5.2 1.6e-07 0.04 0.50 0.50 FALSE
6 GTEx Adrenal Gland CTSW 0.13 0.08 lasso 12 0.06 3.0e-03 4.4 -5.5 3.8e-08 0.05 0.26 0.29 FALSE
7 GTEx Artery Aorta CTSW 0.29 0.26 lasso 7 0.25 3.2e-14 5.4 -5.3 1.0e-07 0.04 0.50 0.50 FALSE
8 GTEx Artery Tibial CTSW 0.12 0.09 enet 22 0.11 1.2e-08 5.4 -5.4 5.6e-08 0.06 0.51 0.49 FALSE
9 GTEx Artery Tibial RAD9A 0.39 0.26 lasso 2 0.24 3.5e-19 -6.7 -6.7 2.6e-11 1.00 0.00 1.00 FALSE
10 GTEx Brain Cerebellar Hemisphere GSTP1 0.25 0.15 enet 16 0.20 8.7e-06 -4.0 5.3 9.1e-08 -0.33 0.53 0.34 FALSE
11 GTEx Brain Cerebellum NDUFV1 0.19 0.01 enet 29 0.05 1.7e-02 3.5 -5.5 4.2e-08 0.30 0.07 0.06 FALSE
12 GTEx Breast Mammary Tissue CTSW 0.25 0.19 lasso 8 0.16 1.3e-08 5.4 -5.6 1.9e-08 0.04 0.47 0.53 FALSE
13 GTEx Breast Mammary Tissue (Male) GSTP1 0.11 -0.01 lasso 2 -0.01 7.7e-01 -4.2 5.4 7.8e-08 -0.40 0.02 0.42 FALSE
14 GTEx Cells EBV-transformed lymphocytes FIBP 0.40 0.21 enet 26 0.29 4.3e-10 5.4 5.8 6.1e-09 -0.07 0.49 0.50 FALSE
15 GTEx Cells Transformed fibroblasts FIBP 0.20 0.13 lasso 5 0.17 1.7e-12 5.4 5.5 3.0e-08 -0.06 0.45 0.55 FALSE
16 GTEx Colon Transverse DPF2 0.19 0.01 lasso 4 0.05 1.6e-03 3.4 5.5 4.8e-08 -0.01 0.09 0.09 FALSE
17 GTEx Colon Transverse CTSW 0.37 0.27 lasso 8 0.26 1.5e-12 5.4 -5.2 2.2e-07 0.04 0.49 0.51 FALSE
18 GTEx Esophagus Mucosa CTSW 0.32 0.19 lasso 6 0.17 1.3e-11 5.4 -5.3 1.1e-07 0.04 0.49 0.51 FALSE
19 GTEx Esophagus Muscularis FIBP 0.11 0.04 lasso 4 0.04 1.2e-03 4.1 5.3 1.1e-07 -0.07 0.56 0.21 FALSE
20 GTEx Esophagus Muscularis CTSW 0.29 0.32 lasso 5 0.32 2.9e-20 5.4 -5.4 5.5e-08 0.05 0.48 0.52 FALSE
21 GTEx Esophagus Muscularis RAD9A 0.25 0.26 lasso 2 0.26 6.2e-16 -6.7 -6.5 6.8e-11 0.99 0.00 1.00 FALSE
22 GTEx Esophagus Muscularis CTD-3074O7.5 0.22 0.02 enet 17 0.09 3.7e-06 -2.0 5.8 8.3e-09 -0.03 0.30 0.45 TRUE
23 GTEx Heart Atrial Appendage PTPRCAP 0.14 0.11 lasso 10 0.09 5.1e-05 -4.4 5.2 2.6e-07 -0.24 0.66 0.03 FALSE
24 GTEx Heart Left Ventricle FIBP 0.12 0.09 lasso 3 0.07 9.8e-05 5.4 5.6 1.9e-08 -0.06 0.46 0.48 FALSE
25 GTEx Liver CDK2AP2 0.30 -0.01 lasso 7 -0.01 4.9e-01 -3.5 -5.5 4.4e-08 0.46 0.02 0.47 FALSE
26 GTEx Liver CTSW 0.27 0.03 lasso 13 0.02 1.0e-01 5.3 -5.1 2.7e-07 0.08 0.06 0.14 FALSE
27 GTEx Lung CTSW 0.33 0.20 lasso 8 0.21 3.2e-16 5.4 -5.4 6.9e-08 0.05 0.48 0.52 FALSE
28 GTEx Muscle Skeletal FIBP 0.12 0.13 enet 10 0.13 2.6e-12 5.4 5.6 1.7e-08 -0.07 0.48 0.52 FALSE
29 GTEx Nerve Tibial CTSW 0.22 0.19 lasso 7 0.18 1.3e-12 5.4 -5.4 6.0e-08 0.04 0.49 0.51 FALSE
30 GTEx Nerve Tibial RAD9A 0.53 0.24 lasso 10 0.23 5.6e-16 -6.7 -6.7 1.9e-11 0.99 0.00 1.00 TRUE
31 GTEx Pancreas CTSW 0.13 0.11 lasso 3 0.08 4.0e-04 5.4 -5.4 5.1e-08 0.05 0.24 0.28 FALSE
32 GTEx Pancreas TMEM134 0.17 0.04 enet 20 0.03 1.5e-02 -4.4 5.4 8.7e-08 -0.16 0.06 0.05 FALSE
33 GTEx Prostate CTSW 0.29 0.26 lasso 8 0.26 2.9e-07 5.4 -5.6 2.3e-08 0.05 0.37 0.37 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic CTSW 0.27 0.22 lasso 12 0.22 1.9e-12 5.4 -5.4 5.9e-08 0.06 0.50 0.50 FALSE
35 GTEx Skin Not Sun Exposed Suprapubic RPS6KB2 0.11 0.00 lasso 6 0.00 2.3e-01 -5.0 5.2 1.6e-07 -0.25 0.04 0.05 FALSE
36 GTEx Skin Not Sun Exposed Suprapubic AP003419.16 0.15 0.08 lasso 5 0.08 6.2e-05 -4.7 5.4 5.4e-08 -0.21 0.50 0.03 FALSE
37 GTEx Skin Sun Exposed Lower leg CTSW 0.19 0.19 lasso 6 0.18 1.1e-14 5.4 -5.4 5.3e-08 0.04 0.49 0.51 FALSE
38 GTEx Spleen CTSW 0.30 0.31 lasso 2 0.26 1.9e-07 5.4 -5.4 5.5e-08 0.04 0.50 0.48 FALSE
39 GTEx Stomach CTSW 0.18 0.20 lasso 7 0.19 1.7e-09 5.4 -5.4 5.4e-08 0.05 0.49 0.51 FALSE
40 GTEx Testis FIBP 0.21 0.22 lasso 5 0.19 6.5e-09 5.4 5.3 1.1e-07 -0.05 0.48 0.52 FALSE
41 GTEx Testis RAD9A 0.72 0.50 lasso 4 0.49 1.1e-24 -6.7 -6.6 3.0e-11 1.00 0.00 1.00 FALSE
42 GTEx Thyroid CTSW 0.18 0.22 lasso 2 0.21 4.6e-16 5.4 -5.4 5.5e-08 0.05 0.49 0.51 FALSE
43 GTEx Uterus PACS1 0.21 -0.01 enet 21 0.05 3.6e-02 4.4 -5.7 9.3e-09 0.15 0.07 0.30 TRUE
44 GTEx Vagina RP11-755F10.1 0.39 0.02 lasso 6 0.09 3.9e-03 2.5 5.1 2.6e-07 -0.02 0.09 0.08 FALSE
45 METSIM Adipose CTSW 0.13 0.12 lasso 10 0.12 3.9e-17 5.4 -5.4 7.9e-08 0.05 0.49 0.51 FALSE
46 METSIM Adipose FIBP 0.05 0.02 blup 344 0.02 1.0e-03 5.4 6.1 1.4e-09 -0.13 0.53 0.45 FALSE
47 METSIM Adipose KLC2 0.06 0.06 blup 323 0.05 1.2e-08 4.1 -5.7 1.5e-08 0.05 0.99 0.01 FALSE
48 ROSMAP Brain Pre-frontal Cortex CDK2AP2 0.03 0.02 enet 11 0.03 1.6e-04 -4.5 6.2 7.1e-10 -0.48 0.27 0.60 FALSE
49 ROSMAP Brain Pre-frontal Cortex FIBP 0.13 0.13 lasso 3 0.15 5.8e-19 5.4 5.3 1.4e-07 -0.04 0.44 0.56 FALSE
50 ROSMAP Brain Pre-frontal Cortex CTSW 0.06 0.03 bslmm 328 0.03 3.6e-05 5.5 -6.9 4.3e-12 0.00 0.35 0.42 TRUE
51 ROSMAP Brain Pre-frontal Cortex SNX32 0.50 0.53 lasso 13 0.54 1.1e-81 5.8 5.4 6.0e-08 -0.03 0.13 0.87 FALSE
52 YFS Blood FIBP 0.04 0.02 bslmm 343 0.03 6.4e-09 5.4 6.0 1.9e-09 -0.15 0.49 0.51 FALSE
53 The Cancer Genome Atlas Bladder Urothelial Carcinoma SNX32 0.05 0.05 blup 60 0.03 1.1e-03 5.8 5.1 3.0e-07 -0.07 0.02 0.97 FALSE
54 The Cancer Genome Atlas Breast Invasive Carcinoma CTSW 0.25 0.39 blup 44 0.41 7.3e-91 5.4 -5.6 1.7e-08 0.05 0.02 0.98 FALSE
55 The Cancer Genome Atlas Breast Invasive Carcinoma SNX32 0.15 0.17 blup 60 0.17 2.9e-34 5.8 5.5 3.0e-08 -0.04 0.00 1.00 FALSE
56 The Cancer Genome Atlas Colon Adenocarcinoma CTSW 0.40 0.34 enet 14 0.36 4.3e-22 5.3 -5.4 7.7e-08 0.04 0.02 0.98 FALSE
57 The Cancer Genome Atlas Esophageal Carcinoma CTSW 0.37 0.17 blup 44 0.24 3.7e-08 5.4 -5.3 1.0e-07 0.06 0.01 0.99 FALSE
58 The Cancer Genome Atlas Glioblastoma Multiforme CTSW 0.16 0.18 enet 16 0.19 2.3e-06 4.4 -5.7 9.9e-09 0.09 0.03 0.94 FALSE
59 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CTSW 0.31 0.32 lasso 4 0.34 1.8e-39 5.5 -5.5 3.5e-08 0.05 0.01 0.99 FALSE
60 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SNX32 0.15 0.14 enet 8 0.15 2.5e-16 3.9 5.1 2.9e-07 -0.05 0.03 0.97 FALSE
61 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CTSW 0.23 0.25 lasso 6 0.25 3.2e-28 5.4 -5.4 5.4e-08 0.05 0.02 0.98 FALSE
62 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SNX32 0.15 0.11 blup 60 0.15 6.0e-17 5.8 6.4 1.7e-10 -0.05 0.00 1.00 FALSE
63 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CTSW 0.32 0.26 lasso 1 0.26 4.3e-15 5.5 -5.5 4.5e-08 0.04 0.02 0.98 FALSE
64 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FIBP 0.05 0.01 blup 44 0.02 1.5e-02 5.8 5.7 9.3e-09 -0.08 0.01 0.80 FALSE
65 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SNX32 0.11 0.06 blup 60 0.09 1.3e-05 5.4 5.2 1.7e-07 -0.01 0.03 0.97 FALSE
66 The Cancer Genome Atlas Brain Lower Grade Glioma CTSW 0.13 0.14 blup 44 0.14 7.0e-16 5.4 -5.6 1.9e-08 0.06 0.02 0.98 FALSE
67 The Cancer Genome Atlas Brain Lower Grade Glioma EFEMP2 0.01 0.00 blup 45 0.01 3.0e-02 3.9 5.5 3.8e-08 -0.09 0.02 0.62 FALSE
68 The Cancer Genome Atlas Brain Lower Grade Glioma FIBP 0.04 0.04 lasso 3 0.04 1.2e-05 5.8 5.8 5.0e-09 -0.03 0.01 0.99 FALSE
69 The Cancer Genome Atlas Brain Lower Grade Glioma SNX32 0.15 0.27 enet 23 0.26 6.1e-30 5.8 5.2 2.2e-07 -0.04 0.01 0.99 FALSE
70 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CTSW 0.63 0.41 lasso 8 0.42 1.2e-21 5.5 -5.5 3.6e-08 0.04 0.02 0.98 FALSE
71 The Cancer Genome Atlas Lung Adenocarcinoma CTSW 0.23 0.29 lasso 7 0.29 1.0e-33 5.5 -5.5 4.1e-08 0.05 0.02 0.98 FALSE
72 The Cancer Genome Atlas Lung Adenocarcinoma FIBP 0.02 0.01 blup 45 0.02 1.3e-03 5.5 5.9 4.1e-09 -0.11 0.02 0.84 FALSE
73 The Cancer Genome Atlas Lung Adenocarcinoma SNX32 0.14 0.09 blup 60 0.13 8.8e-15 5.8 6.5 8.9e-11 -0.07 0.02 0.98 FALSE
74 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CTSW 0.25 0.34 enet 14 0.34 4.1e-40 5.5 -5.5 2.9e-08 0.05 0.02 0.98 FALSE
75 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CTSW 0.20 0.23 lasso 9 0.23 1.5e-15 5.4 -5.5 4.1e-08 0.04 0.02 0.98 FALSE
76 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SNX32 0.08 0.10 blup 60 0.11 6.0e-08 5.8 6.0 1.7e-09 -0.09 0.02 0.98 FALSE
77 The Cancer Genome Atlas Pancreatic Adenocarcinoma CTSW 0.30 0.23 lasso 11 0.24 1.7e-10 5.4 -5.5 3.7e-08 0.05 0.02 0.98 FALSE
78 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CTSW 0.16 0.10 enet 24 0.15 1.9e-06 5.3 -5.2 1.7e-07 0.06 0.02 0.97 FALSE
79 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SNX32 0.30 0.19 lasso 1 0.14 3.9e-06 5.8 5.8 7.2e-09 -0.02 0.01 0.99 FALSE
80 The Cancer Genome Atlas Prostate Adenocarcinoma CTSW 0.29 0.49 enet 12 0.49 3.4e-58 5.4 -5.5 4.5e-08 0.04 0.02 0.98 FALSE
81 The Cancer Genome Atlas Soft Tissue Sarcoma CTSW 0.18 0.22 lasso 3 0.22 4.1e-13 5.4 -5.4 5.6e-08 0.04 0.02 0.98 FALSE
82 The Cancer Genome Atlas Soft Tissue Sarcoma SNX32 0.08 0.08 lasso 2 0.10 1.5e-06 4.3 5.4 7.4e-08 -0.07 0.05 0.94 FALSE
83 The Cancer Genome Atlas Stomach Adenocarcinoma CTSW 0.24 0.35 lasso 7 0.36 3.0e-27 5.5 -5.5 3.8e-08 0.06 0.02 0.98 FALSE
84 The Cancer Genome Atlas Stomach Adenocarcinoma SNX32 0.12 0.13 blup 60 0.13 1.2e-09 5.4 6.9 7.0e-12 -0.08 0.03 0.97 FALSE
85 The Cancer Genome Atlas Testicular Germ Cell Tumors CTSW 0.26 0.29 lasso 9 0.27 4.7e-10 5.4 -5.5 3.9e-08 0.05 0.02 0.98 FALSE
86 The Cancer Genome Atlas Testicular Germ Cell Tumors RPS6KB2 0.12 0.06 blup 35 0.05 5.4e-03 -4.7 5.5 4.4e-08 -0.16 0.01 0.57 TRUE
87 The Cancer Genome Atlas Testicular Germ Cell Tumors SNX32 0.23 0.15 blup 60 0.12 6.3e-05 5.8 5.8 5.3e-09 -0.03 0.01 0.98 FALSE
88 The Cancer Genome Atlas Thyroid Carcinoma CTSW 0.25 0.37 lasso 8 0.37 5.2e-38 5.5 -5.5 4.2e-08 0.05 0.02 0.98 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma FIBP 0.04 0.00 blup 45 0.02 8.0e-03 4.0 6.2 4.5e-10 -0.16 0.01 0.33 FALSE
90 The Cancer Genome Atlas Thyroid Carcinoma SNX32 0.23 0.26 lasso 7 0.25 6.4e-24 5.8 5.8 6.1e-09 -0.04 0.00 1.00 FALSE
91 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma CTSW 0.24 0.21 enet 21 0.24 2.9e-07 5.4 -5.9 3.1e-09 0.08 0.02 0.98 FALSE