[Hub]/) : Traits : Waist circumference : ← →

chr11:46,565,407-48,485,877

Best TWAS P=1.34e-21 · Best GWAS P=1.55e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	8.40	8.0	1.0e-15	-0.48	0.78	0.22	FALSE
2	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	-1.46	6.2	5.1e-10	-0.08	0.35	0.05	FALSE
3	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	8.60	-8.3	1.2e-16	0.50	0.33	0.67	FALSE
4	GTEx	Artery Aorta	MADD	0.09	0.03	enet	22	0.04	1.9e-03	-8.82	6.3	3.7e-10	-0.64	0.06	0.56	FALSE
5	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	8.40	-8.4	4.4e-17	0.49	0.35	0.44	FALSE
6	GTEx	Brain Cerebellar Hemisphere	RP11-750H9.5	0.17	0.25	lasso	6	0.21	3.5e-06	-6.17	6.2	6.7e-10	-0.76	0.30	0.36	TRUE
7	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	-2.17	5.2	2.1e-07	-0.14	0.19	0.12	TRUE
8	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	6.47	5.2	2.3e-07	-0.31	0.42	0.04	FALSE
9	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	-8.50	-8.6	7.1e-18	0.70	0.04	0.19	FALSE
10	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	6.85	-6.6	3.8e-11	0.38	0.30	0.06	FALSE
11	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	6.82	7.1	1.8e-12	-0.47	0.07	0.09	FALSE
12	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	-8.63	8.8	1.4e-18	-0.64	0.12	0.88	TRUE
13	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	-0.24	5.3	1.5e-07	-0.05	0.11	0.15	FALSE
14	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	6.70	-6.2	5.8e-10	0.27	0.86	0.14	FALSE
15	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	8.60	-8.1	6.3e-16	0.40	0.14	0.36	FALSE
16	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	8.60	-8.0	1.4e-15	0.48	0.25	0.20	FALSE
17	GTEx	Esophagus Mucosa	MADD	0.27	0.04	enet	18	0.12	4.1e-08	-2.52	5.4	8.2e-08	-0.57	0.19	0.30	FALSE
18	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	8.40	-8.4	4.4e-17	0.49	0.34	0.65	FALSE
19	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	6.70	7.5	4.9e-14	-0.64	0.48	0.16	FALSE
20	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	8.60	-8.0	1.1e-15	0.41	0.33	0.62	FALSE
21	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	8.40	-8.4	4.2e-17	0.52	0.71	0.27	FALSE
22	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	-2.05	5.8	8.0e-09	-0.09	0.42	0.12	FALSE
23	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	8.40	-8.4	4.4e-17	0.49	0.21	0.40	FALSE
24	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	8.40	-8.8	1.0e-18	0.75	0.16	0.72	FALSE
25	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	6.77	-7.3	2.0e-13	0.45	0.96	0.04	FALSE
26	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	6.12	6.8	1.1e-11	-0.36	0.78	0.08	FALSE
27	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	8.40	-8.1	5.8e-16	0.48	0.40	0.60	FALSE
28	GTEx	Nerve Tibial	CELF1	0.08	0.02	enet	15	0.06	4.3e-05	-9.04	6.5	7.8e-11	-0.75	0.02	0.91	FALSE
29	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	8.40	-7.6	3.1e-14	0.39	0.34	0.66	FALSE
30	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	-3.77	6.1	8.9e-10	-0.77	0.07	0.89	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	8.40	-7.2	5.5e-13	0.44	0.38	0.61	FALSE
32	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	8.40	-8.4	4.8e-17	0.58	0.46	0.55	FALSE
33	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	6.47	-8.1	3.8e-16	0.57	0.49	0.49	FALSE
34	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	6.85	6.9	6.8e-12	-0.41	0.99	0.00	FALSE
35	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	-8.74	-8.6	6.0e-18	0.71	0.08	0.91	FALSE
36	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	6.51	-6.6	5.4e-11	0.42	0.60	0.07	FALSE
37	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	6.52	-6.3	3.5e-10	0.40	1.00	0.00	FALSE
38	METSIM	Adipose	MYBPC3	0.11	0.10	enet	26	0.11	1.0e-15	6.85	-6.0	2.0e-09	0.27	0.99	0.01	FALSE
39	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	6.70	-6.7	2.1e-11	0.44	1.00	0.00	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	6.52	7.0	2.9e-12	-0.45	1.00	0.00	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	-8.74	9.5	1.3e-21	-0.85	0.06	0.94	TRUE
42	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	6.77	5.2	2.2e-07	-0.05	0.41	0.06	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	6.80	-5.5	3.2e-08	0.18	0.96	0.04	FALSE
44	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	-8.54	8.2	1.8e-16	-0.67	0.08	0.88	FALSE
45	YFS	Blood	PSMC3	0.02	0.01	blup	289	0.01	2.8e-05	8.60	6.1	1.1e-09	-0.16	0.39	0.42	FALSE
46	YFS	Blood	PTPMT1	0.03	0.01	lasso	5	0.01	3.2e-04	-8.79	-6.3	3.7e-10	0.39	0.10	0.86	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	6.65	-7.3	2.3e-13	0.46	0.58	0.35	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	MADD	0.11	0.03	enet	14	0.06	1.4e-11	-3.46	6.1	1.0e-09	-0.47	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	6.77	-6.4	1.2e-10	0.46	0.01	0.97	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	8.40	-8.4	4.4e-17	0.49	0.32	0.62	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	-8.78	5.9	4.9e-09	-0.14	0.00	0.21	FALSE
52	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	-8.74	9.1	6.0e-20	-0.64	0.02	0.84	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	-6.17	7.0	3.5e-12	-0.64	0.04	0.57	FALSE
54	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	8.40	-8.1	5.7e-16	0.44	0.54	0.46	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	6.52	-6.6	4.7e-11	0.43	0.95	0.05	TRUE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYBPC3	0.05	0.03	blup	43	0.04	6.0e-05	5.03	-5.8	6.6e-09	0.30	0.01	0.98	TRUE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	6.52	-7.5	7.2e-14	0.47	0.95	0.05	FALSE
58	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	6.68	-6.7	2.3e-11	0.44	0.94	0.06	FALSE
59	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	6.84	6.9	5.9e-12	-0.42	0.27	0.33	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	MADD	0.08	0.01	lasso	5	0.05	3.1e-06	6.77	6.2	4.1e-10	-0.38	0.00	0.95	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	6.52	6.6	5.7e-11	-0.43	0.98	0.02	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3	0.10	0.05	blup	39	0.08	3.7e-09	6.85	5.4	5.2e-08	-0.15	0.99	0.00	FALSE
63	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	6.52	-6.6	5.7e-11	0.43	0.98	0.02	FALSE
64	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	6.82	6.5	6.4e-11	-0.33	0.58	0.04	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	8.40	-8.8	1.7e-18	0.59	0.07	0.43	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	AGBL2	0.04	0.03	blup	49	0.03	7.8e-04	-7.69	6.5	1.1e-10	-0.51	0.05	0.76	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	6.12	7.7	1.8e-14	-0.62	0.06	0.38	FALSE
68	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	6.61	-7.1	8.8e-13	0.45	0.05	0.34	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	8.40	-7.9	2.6e-15	0.52	0.02	0.61	FALSE