Hub : Genes

C10orf26

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0575 0.0211 1.1e-06 0.031 0.019 0.021 0.021 0.028 2.7e-10 5.2e-07 1.9e-07 1.7e-07 2.0e-09
2 TCGA Breast Invasive Carcinoma 0.0257 0.0120 6.1e-04 0.021 0.016 0.017 NA 0.017 2.9e-05 2.8e-04 1.6e-04 NA 1.8e-04
3 TCGA Thyroid Carcinoma 0.0600 0.0280 3.9e-05 0.046 0.042 0.038 NA 0.044 2.8e-05 5.5e-05 1.3e-04 NA 4.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.4 3.8 7.9 -0.2 1.9 2.8
Bipolar Disorder or Schizophrenia 7.7 18.9 36.8 -3.5 2.8 6.1
Depressed Affect (Nagel 2018) 0.8 1.6 2.5 -0.1 1.5 1.6
Depression (Nagel 2018) 1.3 1.9 3.6 0.4 1.9 1.4
Intelligence (Savage-Jansen 2018) 0.9 2.8 5.5 2.4 -1.5 -0.7
Neuroticism (Nagel 2018) 4.4 10.3 18.1 -2.8 2.2 4.3
Schizophrenia (2018) 8.6 17.8 30.5 -4.3 2.1 5.5
Schizophrenia vs Biploar Disorder 4.5 5.9 8.1 -2.8 2.1 2.3
Worry (Nagel 2018) 9.2 19.4 30.0 -3.7 3.8 5.5
Alzheimer’s Disease (in mother) 0.2 0.3 0.4 0.5 0.4 -0.6
Alzheimer’s Disease (in father) 0.5 0.6 1.1 0.7 -0.3 1.0
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 0.5 0.1 -0.1
Crohns Disease (2017) 0.6 1.4 3.8 -0.2 -1.9 -0.6
Irritable Bowel Disease (IBD) 0.8 2.0 3.1 1.8 -1.7 -0.3
Ulcerative Colitis (UC) 2.3 4.2 11.6 3.4 -0.9 -0.6
Major Depression (MDD) 3.6 4.4 11.1 -1.4 0.3 3.3
Reaction Time 3.4 6.4 12.8 -0.5 3.6 2.5
Verbal and Numeric Reasoning (VNR) 1.3 3.1 4.5 2.1 -0.9 -2.0
Breast Cancer 0.7 1.8 3.7 -0.9 1.9 0.9
Ovarian Cancer 0.9 1.2 2.4 -1.6 -1.1 0.1
Prostate Cancer 4.3 6.0 15.4 -0.3 3.9 1.6
Age at First Birth 1.2 1.7 3.4 1.9 -0.4 -1.3
Bipolar Disorder (2011) 3.1 3.0 6.3 0.1 1.6 2.5
Body Mass Index (BMI) (2010) 2.7 3.7 11.1 -0.1 0.0 -3.3
Coronary Artery Disease (CAD) 5.8 6.9 14.2 -2.0 1.6 3.8
Crohns Disease (2012) 1.5 2.3 4.1 -0.9 -2.0 -1.5
Mean Putamen Volume 0.9 1.0 2.7 0.1 -0.6 -1.6
Fasting Glucose 0.7 0.8 1.2 0.0 -1.1 -1.1
HbA1C 1.1 1.2 1.9 -0.2 1.4 1.3
HDL Cholesterol 0.9 1.5 3.0 -1.7 1.2 0.5
LDL Cholesterol 0.4 0.6 1.2 0.6 1.1 0.4
Lupus 2.4 3.7 7.3 2.7 0.0 -1.9
Neuroticism (2016) 1.5 2.2 4.4 -0.0 1.5 2.1
Primary Biliary Cirrhosis 0.6 0.9 1.5 -1.2 -1.1 -0.0
Rheumatoid Arthritis 1.2 1.6 2.5 0.3 -1.5 -1.6
Schizophrenia (2014) 9.1 20.2 36.9 -3.9 3.0 6.1
Triglycerides 0.4 0.7 1.1 1.0 -0.4 1.0
Type 2 Diabetes (T2D) (2012) 5.0 5.8 9.6 -2.8 0.0 3.1
Ulcerative Colitis 1.5 2.2 3.1 1.7 -1.8 -0.7
Blood Eosinophil Count 0.7 5.5 7.3 -2.7 -2.5 1.7
Blood Platelet Count 1.2 13.9 39.4 -0.2 -6.3 -1.5
Blood Red Count 1.1 10.4 17.0 3.7 0.8 4.1
Blood White Count 1.6 11.8 30.8 -2.1 -5.5 -0.4
Heel T-Score 0.3 2.2 3.9 -0.1 -2.0 -1.7
BMI 2.5 14.4 42.6 0.4 -0.6 -6.5
Height 5.5 106.9 256.0 2.8 -16.0 -7.5
Waist Hip Ratio (WHR) 2.6 11.6 25.5 -3.0 -5.0 0.8
Systolic Blood Pressure 10.4 51.8 110.2 -6.6 1.2 10.5
Smoking Status 8.9 21.2 27.9 3.4 -5.3 -4.9
Allergy or Eczema 5.6 14.7 42.1 1.0 6.5 0.8
Cardiovascular Disease 2.8 9.2 21.6 -1.9 -1.6 4.7
Hypothyroidism (self reported) 0.2 0.3 0.8 0.2 -0.9 0.5
Respiratory disease 0.8 1.8 3.7 -0.1 1.9 1.2
Type 2 Diabetes (T2D) (2018) 6.1 11.5 19.9 -1.9 -4.5 -3.3
Lung FEV1/FVC ratio 0.4 2.3 6.5 0.1 -0.5 -2.5
Lung FVC 0.4 1.9 5.7 0.1 2.4 0.2
Neuroticism 4.9 11.7 16.7 -2.5 3.5 4.1
Chronotype (morning person) 4.4 10.1 26.8 5.2 1.3 -1.4
Hair Pigment 0.2 5.5 12.2 -3.5 0.9 1.9
Tanning 0.5 6.7 12.0 0.1 -2.8 -3.5
Hand grip strength (left) 7.5 19.8 28.8 1.8 -5.4 -5.2
Number of treatments/medications taken 1.5 2.6 7.0 -0.9 -0.3 2.6
Average weekly spirits intake 1.4 1.7 5.0 -2.2 0.0 -0.3
Sensitivity / hurt feelings 2.1 3.6 6.1 -2.5 0.6 2.1
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.9 0.6 0.9 0.4
Hearing difficulty/problems: Yes 1.3 2.0 4.6 1.2 -2.1 0.1
Relative age of first facial hair 0.3 0.7 1.7 -1.3 -0.5 -0.2
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 3.4 0.2 0.4 1.8
Ever used hormone-replacement therapy (HRT) 1.7 2.1 4.4 0.0 1.4 2.1
Ever had hysterectomy (womb removed) 1.5 1.6 3.1 1.3 1.8 0.5
Systolic blood pressure, automated reading 8.5 24.7 46.9 -4.9 1.7 6.8
Eye problems/disorders: Diabetes related eye disease 2.7 3.0 4.7 0.2 -2.2 -2.1
Angina 0.5 0.7 1.6 -0.3 -1.3 0.6
Medication for hormone replacement therapy 0.8 0.9 1.2 0.9 0.7 1.1
Vitamin and mineral supplements 1.7 2.4 6.4 -0.5 0.6 2.5
Supplements: Zinc 2.0 2.2 4.7 0.5 -2.2 -1.3
Medication: Co-codamol 1.4 1.6 2.5 -1.2 1.0 1.6
Medication: Metformin 4.2 6.0 12.9 -0.6 -2.2 -3.6
Diabetes (father) 0.6 0.7 1.3 -0.9 -1.1 -0.3
Diabetes (mother) 2.1 2.7 5.9 -1.3 -2.4 -0.9
Severe depression (siblings) 3.5 3.9 7.6 -1.4 1.5 2.8
Pack years adult smoking proportion 1.0 1.6 2.6 -1.1 -1.6 -0.9
Impedance of leg (right) 2.1 10.2 21.7 -3.0 -0.4 4.7
Leg fat-free mass (left) 4.6 24.1 46.6 2.2 -4.6 -6.8
Trunk fat percentage 1.0 4.1 10.2 -1.3 -0.7 -3.2
Hand grip strength (right) 6.0 16.3 25.3 1.1 -4.7 -5.0
Townsend deprivation index at recruitment 1.5 2.1 3.0 0.8 -1.6 -1.7
Current tobacco smoking 4.6 7.6 11.4 1.3 -3.4 -3.1
Average weekly fortified wine intake 0.8 1.0 1.6 -1.3 0.0 1.1
Maternal smoking around birth 3.7 5.4 9.5 0.8 -2.4 -3.1
Fed-up feelings 0.4 0.7 1.6 -0.4 1.3 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.5 0.7 -0.0 -0.4
Relative age voice broke 0.4 0.6 1.3 -1.2 -0.3 0.7
Taking other prescription medications 1.1 1.6 4.6 0.1 0.6 2.1
Age when periods started (menarche) 0.6 1.5 3.8 0.2 -0.8 -2.0
Bilateral oophorectomy (both ovaries removed) 3.4 4.0 7.7 1.3 2.8 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 3.0 -1.7 -1.7 -0.4
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.0 0.8 1.0 0.5
Qualifications: CSEs or equivalent 0.7 1.0 2.4 1.5 -0.7 -0.1
Serious illness, injury or assault to yourself 1.9 2.2 4.5 -2.1 0.3 1.5
High blood pressure 2.4 6.8 16.2 -1.8 -1.0 4.0
Hayfever, allergic rhinitis or eczema 4.6 10.1 28.0 0.9 5.3 1.1
Multivitamins +/- minerals 0.9 1.1 3.1 0.4 0.3 -1.8
Stomach or abdominal pain in last month 0.0 0.1 0.1 0.3 -0.1 -0.1
Supplements: Glucosamine 0.6 0.8 2.0 1.4 0.5 -0.5
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 3.1 0.4 1.8 1.2
Medication: Atenolol 0.8 1.0 2.2 -0.9 -1.5 -0.1
Medication: Levothyroxine sodium 0.8 1.4 1.6 0.9 1.3 1.3
Sitting height 2.9 20.6 54.3 1.6 -7.4 -2.2
Chronic bronchitis/emphysema (father) 1.8 2.1 4.6 -2.1 0.7 1.1
High blood pressure (mother) 3.7 5.2 11.1 -1.2 1.7 3.3
Body mass index (BMI) 1.4 5.9 17.8 0.0 0.0 -4.2
Impedance of leg (left) 1.6 7.9 18.7 -2.2 -0.5 4.3
Leg predicted mass (left) 4.5 23.7 45.7 2.2 -4.5 -6.8
Trunk fat mass 2.3 10.1 23.4 -0.3 -2.6 -4.8
Waist circumference 2.6 9.5 16.7 -0.8 -3.4 -4.1
Number of incorrect matches in round 5.1 8.4 13.8 -1.5 3.0 3.7
Past tobacco smoking 6.8 12.4 24.9 -1.3 5.0 3.2
Alcohol usually taken with meals 0.6 1.0 1.5 -1.1 1.2 0.4
Nervous feelings 6.6 12.3 17.8 -3.8 2.3 4.2
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.8 -0.0 1.7 1.1
Hearing difficulty/problems with background noise 2.7 4.3 11.7 0.6 -3.4 -0.8
Hair/balding pattern: Pattern 2 0.2 0.3 0.8 -0.2 -0.1 -0.9
Had menopause 2.0 2.4 5.2 0.3 2.3 1.4
Had other major operations 0.4 0.5 0.8 0.4 0.7 0.9
Forced vital capacity (FVC) 2.0 7.6 15.1 1.0 -3.9 -2.6
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.9 6.1 -1.6 -2.5 -0.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.3 -0.5 -0.3 0.6
Qualifications: None of the above 0.2 0.4 0.8 0.7 0.0 -0.9
Financial difficulties in last 2 years 1.0 1.4 4.0 -0.3 -2.0 -0.1
Mouth/teeth dental problems 0.7 1.1 1.9 -1.4 1.0 0.5
Heart attack 0.7 0.9 1.5 -1.2 0.3 1.0
Allergy 3.4 7.9 21.3 0.2 -4.6 -1.6
Pain all over the body in last month 1.1 1.1 2.4 0.3 1.5 1.0
Diabetes (self-reported) 5.4 8.3 13.4 -1.5 -3.7 -3.0
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 4.9 0.0 2.2 1.0
Medication: Ramipril 3.5 4.5 10.9 -1.6 0.1 3.3
Medication: Simvastatin 0.8 1.2 2.4 -0.7 -1.6 -0.9
Fluid intelligence score 1.2 2.5 3.6 1.4 -1.3 -1.9
Illnesses of siblings 0.7 1.0 1.5 -0.3 1.1 -1.2
Neuroticism score 3.1 6.5 9.3 -1.2 3.0 3.1
Weight 4.0 19.7 38.9 1.1 -4.4 -6.2
Impedance of arm (right) 1.1 5.2 9.4 -2.0 1.5 3.1
Arm fat percentage (right) 1.2 4.6 13.1 -0.9 0.2 -3.6
Trunk fat-free mass 5.1 29.5 42.4 2.9 -6.5 -6.2
Hip circumference 2.8 12.1 30.8 1.1 -2.1 -5.6
Time employed in main current job 0.4 0.4 1.2 1.1 -0.2 -0.1
Alcohol intake versus 10 years previously 0.7 1.0 2.1 0.6 -0.8 -1.4
Father’s age at death 0.7 0.9 1.4 -0.9 -1.2 -0.7
Worrier / anxious feelings 12.3 23.2 37.9 -2.3 5.1 6.2
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 2.2 0.6 -1.5 -1.4
Falls in the last year 0.2 0.3 0.4 0.7 0.1 0.6
Hair/balding pattern: Pattern 3 0.5 0.8 0.9 0.7 -1.0 0.9
Number of live births 1.7 2.4 3.6 -1.9 0.9 1.6
Forced expiratory volume in 1-second (FEV1) 1.7 5.8 10.1 0.3 -3.2 -2.7
Pulse rate 3.3 5.6 8.0 -1.9 2.8 2.3
Happiness 0.7 0.9 1.2 -1.0 1.1 0.6
Noisy workplace 0.1 0.1 0.3 0.6 0.3 0.0
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.1 -1.2 -1.7 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.6 0.3 -0.8 0.7
Mouth/teeth dental problems: Dentures 1.2 2.0 4.0 1.1 -1.0 -2.0
Asthma 0.7 1.4 3.1 -0.4 1.8 1.0
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.9 -1.2 1.7 0.0
Medication: Cholesterol lowering 0.1 0.2 0.5 0.2 -0.7 -0.4
Depression (self-reported) 0.2 0.3 0.5 0.7 0.2 0.6
Medication: Lansoprazole 1.9 2.2 4.8 -0.6 1.2 2.2
Prospective memory result 0.9 1.1 2.3 -1.5 -0.6 0.7
Lung cancer (father) 0.7 0.8 1.8 1.4 0.0 -0.8
Illnesses of mother 0.4 0.5 1.5 0.2 -0.3 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.2 6.1 1.2 -2.3 -2.5
Pulse wave Arterial Stiffness index 4.1 4.8 7.4 -1.5 2.2 2.7
Impedance of arm (left) 1.4 6.5 13.0 -1.8 1.9 3.6
Arm fat mass (right) 1.8 7.4 20.4 -0.0 -1.3 -4.5
Trunk predicted mass 5.1 29.1 40.6 3.0 -6.4 -6.2
Standing height 4.5 44.4 100.0 2.6 -10.0 -5.2
Length of working week for main job 3.7 4.1 8.4 -1.9 -2.9 -0.7
Exposure to tobacco smoke at home 0.4 0.4 1.3 -1.1 0.0 -0.2
Breastfed as a baby 0.7 0.9 1.4 -0.3 1.1 1.2
Tense / ‘highly strung’ 0.6 0.9 1.5 -0.6 1.2 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 3.4 5.2 11.2 -2.0 -0.5 3.3
Hair/balding pattern: Pattern 4 0.7 1.6 2.4 1.1 1.1 -1.5
Birth weight of first child 5.9 10.7 15.4 3.9 -1.7 -3.7
Peak expiratory flow (PEF) 4.7 10.8 16.9 1.0 -3.8 -4.1
Pulse wave reflection index 4.5 5.6 8.6 2.9 -1.7 -2.3
Ever highly irritable/argumentative for 2 days 1.8 2.1 5.7 -0.1 -0.8 2.4
Loud music exposure frequency 0.7 0.8 1.4 1.2 -0.5 -0.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 0.8 -0.1 0.6
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 4.8 2.2 -0.0 -1.1
Blood clot in the leg (DVT) 1.6 2.0 4.2 -2.1 0.3 1.3
Medication: Paracetamol 3.5 5.9 10.7 -2.5 0.7 3.3
Headache pain in last month 1.8 3.0 5.3 2.3 1.9 0.5
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.2 0.5 0.8 -1.1
Glaucoma (self-reported) 0.5 0.6 1.6 -1.3 -0.4 0.4
Gout (self-reported) 0.6 0.9 1.5 0.1 -1.2 1.1
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.4 0.5 0.1 1.5
Medication: Amlodipine 1.1 1.5 2.6 -0.8 1.1 1.6
Medication: Ventolin 100micrograms inhaler 1.2 1.6 3.5 -1.9 0.2 1.1
Birth weight 11.5 25.0 56.6 7.5 -1.4 -4.0
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.0 0.8 -1.0 -0.1
High blood pressure (siblings) 1.6 2.3 6.7 0.2 -0.5 2.6
Forced vital capacity (FVC), Best measure 1.5 5.5 8.7 1.6 -2.9 -2.3
Body fat percentage 1.1 4.2 10.6 -1.3 -0.5 -3.2
Leg fat percentage (right) 1.1 3.9 9.8 -1.2 -0.6 -3.1
Arm fat-free mass (right) 4.8 24.7 34.6 2.4 -5.8 -5.9
Exposure to tobacco smoke outside home 4.1 5.5 8.6 0.2 -2.9 -2.8
Comparative body size at age 10 1.5 4.0 7.6 -2.0 -0.7 -2.8
Number of full brothers 0.2 0.2 0.4 0.5 -0.6 0.2
Worry too long after embarrassment 3.9 6.5 12.7 -3.6 1.5 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 3.6 4.6 11.4 -0.3 1.5 3.4
Wheeze or whistling in the chest in last year 0.1 0.3 0.7 0.8 -0.0 -0.2
Number of children fathered 0.2 0.2 0.3 -0.3 -0.4 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 2.8 3.3 6.8 -0.8 -2.6 1.6
Age at first live birth 0.7 1.2 2.4 0.9 -0.4 -1.6
Pulse wave peak to peak time 5.7 6.8 9.4 1.6 -2.9 -3.1
Health satisfaction 0.8 1.0 2.3 -1.5 -0.6 0.6
Shortness of breath walking on level ground 0.4 0.4 1.0 -0.0 0.6 1.0
Qualifications: College or University degree 1.1 3.4 6.9 -2.6 0.9 1.6
Eye problems/disorders: None of the above 1.4 1.6 2.0 1.0 1.3 -1.4
Mouth/teeth dental problems: Loose teeth 1.2 1.5 3.2 0.2 -1.1 -1.8
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.3 -0.5 0.1
Medication for pain relief, constipation, heartburn 2.0 3.4 5.2 2.2 -0.5 -2.3
Neck or shoulder pain in last month 0.7 1.0 1.8 -1.3 0.4 1.1
Medication: Blood pressure 1.2 2.1 5.5 -0.6 -0.6 2.3
Angina (self-reported) 0.6 0.8 1.2 -0.7 -0.8 1.1
Migraine (self-reported) 7.3 9.1 15.3 3.5 0.3 -3.9
Medication: Ibuprofen 0.6 0.7 1.3 -1.2 0.8 -0.2
Medication: Allopurinol 0.7 0.9 1.8 -0.5 -1.3 0.8
Medication: Omeprazole 0.3 0.4 1.0 -0.3 0.1 1.0
Medication: Seretide 50 evohaler 0.5 0.6 1.2 0.1 -1.1 -0.8
Mean time to correctly identify matches 1.6 3.0 4.7 -0.4 2.2 2.0
Heart disease (mother) 3.5 4.3 10.2 -1.6 0.6 3.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.5 -0.3 -1.2 -0.3
Whole body fat mass 2.3 9.8 23.9 -0.3 -2.3 -4.9
Leg fat mass (right) 2.6 10.3 25.0 0.1 -2.4 -5.0
Arm predicted mass (right) 4.8 24.6 34.3 2.3 -5.8 -5.9
Pulse rate, automated reading 1.7 5.4 7.4 -2.0 2.7 2.2
Alcohol intake frequency. 0.7 1.6 2.9 0.2 -1.4 -1.7
Comparative height size at age 10 3.5 19.5 45.4 1.4 -6.7 -3.3
Number of full sisters 0.3 0.4 0.5 -0.6 -0.7 -0.6
Suffer from ‘nerves’ 3.7 5.8 10.0 -1.8 2.0 3.2
Overall health rating 0.4 0.8 2.2 1.5 0.5 -0.0
Chest pain or discomfort 0.6 0.9 2.3 1.5 -0.1 0.5
Had major operations 0.6 0.7 1.9 -0.1 0.2 -1.4
Age at last live birth 0.8 1.2 2.6 0.3 -0.9 -1.6
Family relationship satisfaction 0.3 0.3 0.6 -0.7 -0.8 0.0
Leg pain on walking 0.8 1.0 2.7 -0.2 0.6 1.6
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 2.1 -0.8 -1.4 -0.4
Commuting to job workplace: Car/motor vehicle 3.1 3.6 7.4 2.7 -0.4 -1.8
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.6 0.2 1.6 -1.5
Medication: Aspirin 0.7 0.9 2.5 -0.2 -1.6 0.3
Supplements: Vitamin C 0.8 1.0 1.8 0.6 -0.9 -1.3
Knee pain experienced in last month 0.7 1.1 2.5 0.9 0.2 -1.6
Hypertension (Self-reported) 2.3 6.5 16.0 -1.7 -0.7 4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 0.4 0.1 0.6
Illnesses of father: Heart disease 1.0 1.4 1.8 -0.9 -1.3 1.2
Illnesses of siblings: Diabetes 1.5 1.8 4.5 -0.4 -2.1 -0.8
Smoking status: Previous 2.5 3.8 9.7 0.8 -3.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 5.7 11.8 24.0 1.2 -4.9 -3.2
Whole body fat-free mass 5.0 28.6 44.2 2.8 -5.8 -6.7
Leg fat-free mass (right) 4.6 24.8 46.0 2.7 -4.6 -6.8
Arm fat percentage (left) 1.0 4.0 11.2 -0.8 0.5 -3.4
Average weekly red wine intake 0.7 1.1 1.9 -1.1 0.1 1.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 -0.5 -1.0 -0.6
Mood swings 1.1 2.0 3.3 0.3 1.8 1.6
Loneliness, isolation 0.3 0.4 0.9 0.4 1.0 0.2
Long-standing illness, disability or infirmity 0.5 0.8 2.0 0.3 -1.4 -0.5
Ever had bowel cancer screening 1.7 2.0 3.5 1.6 -1.9 0.2
Diabetes diagnosed by doctor 4.7 7.8 11.0 -1.5 -3.3 -3.2
Ever had stillbirth, spontaneous miscarriage or termination 3.1 3.3 6.8 -2.6 -1.7 0.6
Friendships satisfaction 0.3 0.3 0.7 -0.5 0.8 0.0
Qualifications: nursing, teaching 1.5 2.3 4.8 -2.2 -1.2 0.8
Commuting to job workplace: Walk 3.3 3.5 5.6 -0.5 2.4 2.2
Eye problems/disorders: Cataract 0.6 0.7 1.1 -1.0 -1.0 0.2
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 1.5 1.1 -1.2 1.1
Medication for cholesterol 1.7 2.6 6.9 0.7 0.6 -2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 5.3 0.6 -2.3 0.1
Back pain experienced in last month 0.2 0.3 0.5 0.7 -0.6 -0.4
Mineral and other dietary supplements 1.1 1.5 3.6 -0.9 0.2 1.9
Breast cancer (self-reported) 1.0 1.2 3.4 1.8 -0.2 -0.4
Asthma (self-reported) 0.9 1.8 3.9 -0.5 2.0 1.1
Osteoporosis (self-reported) 0.5 0.7 1.3 -0.8 -0.0 1.1
Osteoarthritis (self-reported) 0.7 0.9 1.5 0.4 1.1 1.2
Medication: Aspirin 0.7 0.9 2.5 -0.3 -1.6 0.5
Medication: Gliclazide 1.7 1.9 3.1 -0.8 -1.8 -1.4
Illnesses of father: None of the above (group 1) 2.9 3.6 7.0 1.7 0.9 -2.6
Smoking status: Current 5.0 7.9 10.6 1.6 -3.3 -3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.9 0.2 0.2 -1.7
Whole body water mass 4.9 28.1 44.1 2.7 -5.8 -6.6
Leg predicted mass (right) 4.6 24.5 45.5 2.7 -4.5 -6.7
Arm fat mass (left) 1.8 7.5 20.6 0.0 -1.4 -4.5
Number of self-reported non-cancer illnesses 2.0 3.5 8.8 0.5 1.3 3.0
Average weekly champagne plus white wine intake 1.6 2.2 3.3 1.8 -0.1 -1.8
Miserableness 0.4 0.8 1.2 0.9 -1.1 -0.5
Guilty feelings 0.1 0.2 0.4 0.3 0.2 0.6
Wears glasses or contact lenses 0.8 0.9 2.1 -0.7 -0.2 1.5
Ever taken oral contraceptive pill 2.1 2.4 6.0 -0.1 -1.0 -2.5
Hearing aid user 0.4 0.5 0.9 0.3 1.0 0.7
Mother’s age at death 0.6 0.8 2.1 0.5 -0.3 -1.4
Financial situation satisfaction 1.8 2.2 4.4 0.9 -2.1 -1.2
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.0 -0.2 -1.4 -0.5
Commuting to job workplace: Public transport 1.5 1.8 4.9 -2.2 -0.0 0.8
Eye problems/disorders: Glaucoma 0.8 1.0 2.8 -1.7 -0.3 0.3
Medication: Blood pressure 1.5 2.8 5.0 -1.4 -1.2 2.2
Pain type(s) experienced in last month: Hip pain 2.2 2.8 6.3 -0.7 2.5 1.2
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.5 0.4 0.3 -0.7
High cholesterol (Self-reported) 0.5 0.8 1.4 -0.9 -1.2 -0.6
Medication: Bendroflumethiazide 2.2 3.3 5.6 -1.3 -1.6 2.4
Medication: Paracetamol 2.6 4.0 8.0 -1.9 0.6 2.8
Medication: Lisinopril 2.8 3.7 6.4 -1.7 -1.3 2.5
Medication: Atorvastatin 0.1 0.1 0.2 0.3 0.3 0.5
Illnesses of father: High blood pressure 1.7 2.1 5.4 -0.9 -0.2 2.3
Alcohol drinker status: Never 0.3 0.4 0.6 0.8 0.4 -0.6
Ever smoked 5.7 9.9 15.1 1.3 -3.9 -3.6
Basal metabolic rate 4.8 26.7 43.7 2.3 -5.6 -6.6
Leg fat percentage (left) 1.1 3.9 10.8 -0.7 -0.6 -3.3
Arm fat-free mass (left) 5.0 25.2 39.1 2.3 -5.6 -6.2
Number of operations (self-reported) 0.2 0.3 0.9 -0.1 1.0 -0.0
Average weekly beer plus cider intake 0.4 0.5 0.8 0.6 -0.7 0.9
Irritability 1.1 1.8 4.1 2.0 -0.7 -1.0
Risk taking 0.6 0.8 1.5 0.9 -0.2 -1.2
Ever had prostate specific antigen (PSA) test 1.2 1.4 1.9 1.3 1.4 0.6
Fractured/broken bones in last 5 years 3.4 4.4 5.2 -2.2 1.8 2.3
Age started oral contraceptive pill 0.3 0.4 0.6 0.2 0.7 -0.7
Diastolic blood pressure, automated reading 1.7 5.1 7.8 -0.5 -2.7 2.8
Ever depressed for a whole week 2.4 2.9 3.8 -1.9 -1.4 1.7
Unable to work because of sickness or disability 0.9 1.2 2.8 1.7 -0.8 0.1
Commuting to job workplace: Cycle 0.4 0.5 0.7 -0.8 -0.8 0.4
Myopia 0.0 0.0 0.1 -0.0 0.3 -0.2
Vascular/heart problems diagnosed by doctor 2.2 6.0 13.6 1.8 1.0 -3.7
Cholesterol lowering medication 0.8 1.2 2.8 -1.7 -0.7 0.6
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.7 0.0 0.9 0.7
Pain experienced in last month 0.8 1.4 2.6 -0.4 -1.6 -1.2
Supplements: Calcium 0.7 0.7 2.0 0.3 -0.3 -1.4
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.2 -0.3 0.5
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.4 -1.2 0.3 0.9
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 3.0 -1.7 0.4 1.5
Heart disease (siblings) 0.7 0.9 2.3 0.5 -1.5 0.4
Alcohol drinker status: Previous 0.4 0.5 1.3 0.2 0.0 1.1
Pack years of smoking 0.9 1.3 2.4 -0.9 -1.5 -0.9
Impedance of whole body 1.7 8.7 19.7 -2.3 1.0 4.4
Leg fat mass (left) 2.7 10.6 25.9 0.3 -2.4 -5.1
Arm predicted mass (left) 5.0 25.3 39.4 2.0 -5.7 -6.3