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chr5:73,626,450-75,704,085

Best TWAS P=4.15e-29 · Best GWAS P=2.25e-30 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	POC5	0.17	0.16	lasso	5	0.15	5.2e-18	-11.1	11.2	4.2e-29	-0.90	0.05	0.95	TRUE
18	GTEx	Spleen	POLK	0.18	-0.01	lasso	16	0.03	5.1e-02	-5.1	-9.5	2.7e-21	0.59	0.16	0.23	TRUE
5	GTEx	Adrenal Gland	GCNT4	0.13	0.02	lasso	8	0.01	1.3e-01	-7.7	-9.3	9.7e-21	0.49	0.07	0.81	TRUE
29	ROSMAP	Brain Pre-frontal Cortex	POC5	0.05	0.00	blup	384	0.02	8.6e-04	-7.6	-8.1	5.4e-16	0.57	0.29	0.14	TRUE
4	GTEx	Adipose Visceral Omentum	POC5	0.13	0.08	lasso	9	0.08	6.1e-05	-7.7	-7.7	1.5e-14	0.60	0.82	0.07	TRUE
21	GTEx	Stomach	POC5	0.10	0.06	enet	12	0.08	8.3e-05	-8.1	-6.3	3.9e-10	0.43	0.56	0.02	TRUE
28	ROSMAP	Brain Pre-frontal Cortex	POLK	0.03	0.01	lasso	7	0.02	3.9e-03	-8.9	-10.1	6.0e-24	0.81	0.27	0.62	FALSE
27	METSIM	Adipose	POLK	0.05	0.01	enet	16	0.03	4.3e-05	-9.6	-9.8	7.6e-23	0.58	0.96	0.03	FALSE
20	GTEx	Spleen	CTC-366B18.2	0.16	0.11	lasso	3	0.14	2.2e-04	-7.9	-9.7	3.8e-22	0.72	0.12	0.55	FALSE
7	GTEx	Brain Cerebellar Hemisphere	POLK	0.27	0.20	lasso	6	0.16	8.3e-05	-7.9	-9.3	1.0e-20	0.64	0.33	0.20	FALSE
8	GTEx	Brain Cerebellar Hemisphere	POC5	0.31	0.15	enet	18	0.30	1.6e-08	-7.9	-8.9	6.4e-19	0.61	0.54	0.32	FALSE
23	GTEx	Testis	GCNT4	0.42	0.35	enet	62	0.37	3.8e-17	-7.4	-8.8	9.4e-19	0.50	1.00	0.00	FALSE
25	GTEx	Thyroid	CTC-366B18.2	0.06	0.03	lasso	9	0.02	6.2e-03	-8.8	-8.7	3.5e-18	0.62	0.28	0.23	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	POC5	0.04	0.00	enet	7	0.03	2.1e-04	-11.1	8.6	6.0e-18	-0.77	0.02	0.60	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	ANKDD1B	0.07	0.00	bslmm	382	0.03	7.0e-05	-6.3	8.4	5.5e-17	-0.63	0.08	0.57	FALSE
11	GTEx	Cells Transformed fibroblasts	POLK	0.06	0.04	lasso	3	0.04	1.0e-03	-8.1	8.3	1.1e-16	-0.61	0.22	0.51	FALSE
19	GTEx	Spleen	POC5	0.42	0.37	lasso	4	0.34	1.3e-09	-7.9	-8.0	1.3e-15	0.57	0.93	0.04	FALSE
34	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMGCR	0.04	0.02	enet	4	0.03	6.0e-03	-7.9	-8.0	1.4e-15	0.57	0.02	0.66	FALSE
9	GTEx	Brain Hypothalamus	CTC-366B18.4	0.26	0.12	lasso	8	0.07	9.0e-03	-7.9	8.0	1.7e-15	-0.56	0.10	0.09	FALSE
3	GTEx	Adipose Subcutaneous	POC5	0.08	0.07	lasso	7	0.07	3.2e-06	-7.9	-7.9	2.7e-15	0.56	0.96	0.00	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLK	0.03	0.01	blup	53	0.01	1.6e-02	-5.6	7.9	2.8e-15	-0.57	0.31	0.44	FALSE
36	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	POC5	0.24	0.13	blup	70	0.14	1.2e-04	-8.1	-7.9	3.6e-15	0.73	0.05	0.79	FALSE
6	GTEx	Artery Tibial	GCNT4	0.08	0.07	lasso	2	0.04	3.9e-04	-7.7	7.8	6.2e-15	-0.44	0.65	0.11	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	POC5	0.47	0.36	lasso	4	0.39	1.3e-13	-7.9	-7.8	8.3e-15	0.57	1.00	0.00	FALSE
17	GTEx	Pancreas	POC5	0.32	0.23	lasso	3	0.21	3.5e-09	-7.7	-7.7	1.3e-14	0.57	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	POC5	0.15	0.17	lasso	6	0.16	3.4e-12	-7.7	-7.7	1.6e-14	0.57	1.00	0.00	FALSE
15	GTEx	Esophagus Mucosa	POC5	0.18	0.16	lasso	1	0.15	4.8e-10	-7.7	-7.7	1.6e-14	0.57	1.00	0.00	FALSE
16	GTEx	Nerve Tibial	POC5	0.16	0.12	lasso	5	0.10	7.6e-08	-7.6	-7.7	1.8e-14	0.57	0.99	0.00	FALSE
22	GTEx	Testis	POC5	0.27	0.13	lasso	8	0.09	8.1e-05	-8.4	7.6	3.1e-14	-0.65	0.51	0.30	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ANKRD31	0.10	0.13	lasso	9	0.13	3.9e-15	-7.4	6.9	5.7e-12	-0.33	1.00	0.00	FALSE
14	GTEx	Esophagus Mucosa	COL4A3BP	0.09	0.06	lasso	5	0.05	4.2e-04	-5.3	6.8	7.3e-12	-0.51	0.67	0.20	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	GCNT4	0.10	0.06	enet	6	0.05	8.7e-04	-4.1	6.7	1.6e-11	-0.41	0.08	0.55	FALSE
26	METSIM	Adipose	POC5	0.11	0.09	enet	29	0.10	7.5e-15	-7.6	-6.7	2.6e-11	0.48	1.00	0.00	FALSE
24	GTEx	Thyroid	POC5	0.26	0.23	enet	15	0.23	1.8e-17	-7.6	-6.6	4.3e-11	0.49	1.00	0.00	FALSE
13	GTEx	Colon Transverse	POC5	0.23	0.16	lasso	4	0.18	6.0e-09	-7.6	-6.0	1.9e-09	0.39	0.96	0.00	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GCNT4	0.17	0.00	blup	50	0.05	1.5e-06	-6.4	-5.3	1.2e-07	0.27	0.00	0.25	FALSE