Hub : Genes

IMPG1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0700	0.0380	0.013	0.012	0.007	0.016	0.016	0.020	0.01000	0.037	0.0037	0.0046	0.0015
2	TCGA	Lung Adenocarcinoma	0.0491	0.0236	0.007	0.030	0.018	0.017	NA	0.019	0.00019	0.003	0.0038	NA	0.0024
3	TCGA	Thyroid Carcinoma	0.0820	0.0360	0.005	0.001	0.008	0.002	NA	-0.003	0.22000	0.048	0.2000	NA	0.7900

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.2	1.9	-0.9	1.4	1.0
Bipolar Disorder or Schizophrenia	0.4	1.1	1.7	-1.3	0.8	0.9
Depressed Affect (Nagel 2018)	0.6	1.2	1.8	1.3	-0.1	-1.3
Depression (Nagel 2018)	1.3	1.9	3.3	-1.1	1.8	1.1
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.4	-1.8	2.3	-0.6
Neuroticism (Nagel 2018)	0.6	1.4	2.4	1.5	-0.5	-1.3
Schizophrenia (2018)	0.2	0.4	1.0	-1.0	-0.1	0.3
Schizophrenia vs Biploar Disorder	1.5	2.0	4.1	2.0	-0.6	1.2
Worry (Nagel 2018)	1.1	2.4	3.1	1.4	-1.4	-1.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.5	0.0	-0.3
Alzheimer’s Disease (in father)	2.5	2.7	7.7	0.6	-2.8	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.1	0.4	-1.1	-0.9
Crohns Disease (2017)	0.1	0.2	0.3	0.6	-0.3	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	0.8	-0.4	0.9
Ulcerative Colitis (UC)	0.3	0.6	0.9	0.8	-0.4	0.9
Major Depression (MDD)	0.6	0.7	1.3	0.3	-1.2	-0.8
Reaction Time	0.7	1.3	3.5	0.3	1.9	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.1	0.7	0.1
Breast Cancer	0.2	0.4	0.9	0.6	-0.3	-1.0
Ovarian Cancer	0.9	1.3	2.1	-0.8	1.0	1.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.5	0.8	-0.8	0.1	0.9
Bipolar Disorder (2011)	1.1	1.1	2.1	-0.1	1.4	1.1
Body Mass Index (BMI) (2010)	1.1	1.5	2.7	0.4	-1.4	-1.6
Coronary Artery Disease (CAD)	0.6	0.7	1.2	-0.5	1.1	-0.7
Crohns Disease (2012)	0.5	0.7	1.4	0.9	-1.2	0.2
Mean Putamen Volume	0.7	0.8	2.0	-0.2	-0.5	-1.4
Fasting Glucose	1.8	2.1	3.3	0.3	1.8	1.7
HbA1C	1.4	1.5	2.7	-0.8	1.6	1.1
HDL Cholesterol	0.5	0.9	1.8	-1.3	0.4	-0.8
LDL Cholesterol	1.4	2.3	3.0	1.4	-1.4	-1.7
Lupus	1.3	2.0	2.9	-0.3	-1.7	-1.7
Neuroticism (2016)	0.2	0.4	0.7	-0.1	-0.6	-0.8
Primary Biliary Cirrhosis	0.6	0.9	1.4	0.8	-0.7	-1.2
Rheumatoid Arthritis	0.4	0.6	1.1	-1.1	-0.2	-0.8
Schizophrenia (2014)	0.1	0.1	0.3	0.2	-0.5	0.2
Triglycerides	0.3	0.6	0.9	-0.9	0.8	-0.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.5	-0.6	1.9	-0.5
Ulcerative Colitis	0.5	0.7	1.7	0.6	-1.3	0.4
Blood Eosinophil Count	0.0	0.3	0.7	-0.3	0.0	-0.8
Blood Platelet Count	0.0	0.5	1.4	-0.5	-1.2	0.0
Blood Red Count	0.4	3.5	7.4	-2.7	1.6	0.8
Blood White Count	0.0	0.3	0.6	0.8	-0.3	0.4
Heel T-Score	1.2	9.5	14.4	-2.8	3.8	2.5
BMI	0.1	0.6	1.4	-0.3	-0.4	-1.2
Height	2.8	53.1	85.4	-7.0	9.2	5.0
Waist Hip Ratio (WHR)	0.1	0.6	1.2	-0.6	1.1	0.5
Systolic Blood Pressure	0.8	4.0	11.2	0.5	-0.8	-3.3
Smoking Status	1.2	2.9	5.5	1.0	-2.3	-1.5
Allergy or Eczema	0.8	2.1	5.5	0.7	-0.6	2.4
Cardiovascular Disease	0.3	0.9	2.5	-0.3	-0.2	-1.6
Hypothyroidism (self reported)	0.1	0.3	0.4	0.5	-0.4	0.7
Respiratory disease	0.6	1.2	2.7	-0.2	0.9	1.7
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.9	-0.9	1.7	0.0
Lung FEV1/FVC ratio	1.6	8.2	14.3	1.8	-2.7	-3.8
Lung FVC	1.4	7.1	10.6	0.6	-3.3	-3.2
Neuroticism	1.1	2.6	4.5	1.7	-0.5	-2.1
Chronotype (morning person)	0.6	1.3	2.5	0.6	-1.1	-1.6
Hair Pigment	0.1	1.5	2.6	-1.2	1.6	0.6
Tanning	0.0	0.6	0.9	0.8	-1.0	-0.3
Hand grip strength (left)	0.2	0.5	0.7	0.6	-0.6	-0.8
Number of treatments/medications taken	0.0	0.0	0.1	0.2	0.2	-0.3
Average weekly spirits intake	0.3	0.3	1.0	-0.0	0.2	-1.0
Sensitivity / hurt feelings	0.4	0.6	1.2	1.1	-0.8	-0.1
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.0	-1.4	1.2	-0.9
Hearing difficulty/problems: Yes	0.2	0.3	0.9	0.1	0.0	0.9
Relative age of first facial hair	0.6	1.2	3.5	0.2	-1.9	0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.7	1.3	0.2	0.1
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	-1.4	-0.9	-0.2
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.1	-0.3	-0.2
Systolic blood pressure, automated reading	0.4	1.2	3.3	-0.2	-0.5	-1.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.7	0.8	0.4	0.8
Angina	0.2	0.2	0.3	0.5	-0.4	-0.6
Medication for hormone replacement therapy	1.7	1.9	3.9	0.3	-2.0	-1.3
Vitamin and mineral supplements	0.1	0.2	0.2	0.4	-0.4	0.5
Supplements: Zinc	1.0	1.1	2.5	-1.6	0.9	-0.0
Medication: Co-codamol	0.5	0.5	1.4	-1.2	0.4	0.0
Medication: Metformin	2.1	2.9	4.4	-1.8	2.1	1.0
Diabetes (father)	0.9	1.1	2.2	1.5	-1.1	0.3
Diabetes (mother)	0.4	0.6	1.7	0.1	0.1	1.3
Severe depression (siblings)	0.0	0.0	0.0	-0.0	-0.1	-0.0
Pack years adult smoking proportion	0.4	0.5	1.0	1.0	-0.5	-0.6
Impedance of leg (right)	0.4	2.1	4.4	-0.1	1.4	2.1
Leg fat-free mass (left)	1.3	7.1	10.3	-3.2	3.1	-1.0
Trunk fat percentage	0.4	1.7	2.9	-1.7	1.5	0.2
Hand grip strength (right)	0.4	1.1	1.7	0.8	-1.0	-1.3
Townsend deprivation index at recruitment	0.7	0.9	1.6	1.3	-0.8	-0.7
Current tobacco smoking	0.0	0.1	0.2	-0.0	-0.4	-0.2
Average weekly fortified wine intake	1.4	1.6	3.5	-1.9	-0.2	1.1
Maternal smoking around birth	1.9	2.7	4.8	1.1	-1.5	-2.2
Fed-up feelings	0.7	1.2	2.3	1.1	-0.5	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.7	4.7	-2.1	2.2	1.3
Relative age voice broke	1.6	2.4	7.2	0.2	-2.7	0.1
Taking other prescription medications	0.0	0.0	0.1	-0.3	0.1	0.0
Age when periods started (menarche)	0.4	1.0	2.4	0.8	-1.6	-0.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.4	0.6	-1.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	0.6	-0.4	0.5	0.8
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.3	0.6	0.2
Qualifications: CSEs or equivalent	1.0	1.3	1.8	0.6	-1.4	-1.4
Serious illness, injury or assault to yourself	1.4	1.7	4.8	-0.2	0.5	2.2
High blood pressure	0.5	1.3	2.1	-1.1	0.7	-1.4
Hayfever, allergic rhinitis or eczema	1.4	3.0	3.6	1.9	-1.4	1.9
Multivitamins +/- minerals	0.2	0.2	0.6	-0.0	0.2	-0.8
Stomach or abdominal pain in last month	1.0	1.2	1.9	0.7	1.1	1.4
Supplements: Glucosamine	0.2	0.2	0.4	0.6	-0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.4	0.8	-0.1
Medication: Atenolol	0.5	0.6	1.0	-0.5	1.0	0.7
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.5	0.1	0.6
Sitting height	0.8	5.8	10.3	-2.0	3.2	1.7
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	-0.7	0.5	-0.8
High blood pressure (mother)	1.1	1.6	3.2	1.8	-0.7	-1.0
Body mass index (BMI)	0.5	2.0	2.2	-1.5	1.2	-1.5
Impedance of leg (left)	0.4	1.9	4.6	0.3	1.0	2.1
Leg predicted mass (left)	1.3	7.1	10.3	-3.2	3.2	-0.9
Trunk fat mass	1.0	4.2	6.5	-2.5	2.5	0.0
Waist circumference	1.2	4.3	7.3	-2.4	2.7	-0.1
Number of incorrect matches in round	0.4	0.6	0.9	0.6	-0.7	1.0
Past tobacco smoking	0.3	0.6	1.4	-0.1	1.2	0.6
Alcohol usually taken with meals	1.0	1.6	2.6	-1.3	0.5	1.6
Nervous feelings	0.4	0.7	1.1	0.5	-0.8	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	-0.6	-0.1	-1.0
Hearing difficulty/problems with background noise	0.1	0.1	0.4	0.1	0.1	0.6
Hair/balding pattern: Pattern 2	1.3	1.7	3.8	-0.5	1.0	-1.9
Had menopause	2.0	2.5	5.7	-2.4	0.4	1.3
Had other major operations	1.5	1.8	3.1	1.8	-1.5	0.0
Forced vital capacity (FVC)	0.1	0.5	0.7	-0.6	0.8	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	5.6	-1.6	2.4	0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	0.1	-0.2	-0.9
Qualifications: None of the above	0.4	0.9	2.0	0.8	-1.4	-0.3
Financial difficulties in last 2 years	0.6	0.8	1.7	0.7	1.3	0.5
Mouth/teeth dental problems	0.7	1.1	1.7	0.2	-1.2	-1.3
Heart attack	0.6	0.8	1.9	-0.4	0.6	-1.4
Allergy	0.8	1.9	4.8	-0.9	0.3	-2.2
Pain all over the body in last month	0.2	0.2	0.4	0.3	-0.6	-0.2
Diabetes (self-reported)	0.7	1.1	1.9	-0.9	1.4	0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.0	-1.0	-0.2	-0.5
Medication: Ramipril	3.5	4.5	7.2	-2.7	2.5	-0.4
Medication: Simvastatin	1.0	1.4	2.1	-1.0	1.4	1.1
Fluid intelligence score	0.3	0.7	1.5	-0.1	1.2	0.7
Illnesses of siblings	0.5	0.7	0.8	0.8	-0.8	-0.9
Neuroticism score	0.9	1.8	2.4	1.5	-0.8	-1.6
Weight	1.6	7.8	14.1	-3.0	3.8	0.0
Impedance of arm (right)	0.7	3.2	4.7	1.9	-1.2	2.2
Arm fat percentage (right)	0.1	0.4	0.5	-0.6	0.4	-0.7
Trunk fat-free mass	2.0	11.3	21.7	-3.5	4.7	-0.5
Hip circumference	1.9	8.4	14.7	-3.2	3.8	0.5
Time employed in main current job	0.8	0.9	2.3	-0.5	1.5	0.1
Alcohol intake versus 10 years previously	1.0	1.6	4.2	-0.6	2.0	0.4
Father’s age at death	0.1	0.2	0.4	0.3	-0.0	0.6
Worrier / anxious feelings	0.4	0.8	1.3	1.1	-0.8	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.3	0.4	1.5	0.2
Falls in the last year	0.6	0.8	1.5	-0.9	0.1	1.2
Hair/balding pattern: Pattern 3	0.7	1.0	2.9	0.5	-0.0	1.7
Number of live births	1.3	1.8	5.3	0.3	-2.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.7	-0.4	0.0	-1.3
Pulse rate	0.3	0.5	1.0	-0.5	0.5	1.0
Happiness	1.1	1.3	1.7	-1.2	0.9	-1.3
Noisy workplace	0.8	1.0	2.4	0.3	-0.6	-1.6
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.3	0.1	0.5	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.0	-0.5	-1.0	0.4
Mouth/teeth dental problems: Dentures	0.6	1.0	1.5	-1.0	0.7	1.2
Asthma	0.4	0.8	2.3	-0.2	0.3	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	1.1	-0.8	-0.4
Medication: Cholesterol lowering	1.0	1.6	2.5	-1.4	1.6	-0.5
Depression (self-reported)	0.6	0.7	1.9	0.3	-0.5	-1.4
Medication: Lansoprazole	0.7	0.8	2.2	0.0	0.2	1.5
Prospective memory result	1.1	1.4	3.6	-0.6	-1.9	0.4
Lung cancer (father)	1.6	1.8	5.2	-0.5	-0.3	-2.3
Illnesses of mother	1.1	1.3	3.2	-1.8	0.9	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.9	-0.3	-0.1	-1.7
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.2	0.3	0.0
Impedance of arm (left)	0.8	3.6	6.0	1.8	-1.2	2.4
Arm fat mass (right)	0.7	2.7	4.4	-1.8	2.1	-0.6
Trunk predicted mass	1.9	10.9	21.1	-3.3	4.6	-0.6
Standing height	1.8	17.6	31.8	-3.5	5.6	2.9
Length of working week for main job	1.7	1.8	5.5	-0.0	-0.1	-2.4
Exposure to tobacco smoke at home	2.0	2.3	3.6	1.9	-1.5	-0.9
Breastfed as a baby	0.2	0.3	0.4	0.7	0.1	0.6
Tense / ‘highly strung’	0.4	0.7	1.2	-0.6	-0.7	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	4.9	1.3	-2.2	-1.2
Hair/balding pattern: Pattern 4	0.4	1.0	1.8	-0.3	-1.1	-1.3
Birth weight of first child	0.9	1.7	2.4	-1.4	0.9	-1.5
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.1	0.2	0.7
Pulse wave reflection index	0.8	1.0	1.4	1.2	-1.2	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.7	0.5	0.8	0.2
Loud music exposure frequency	1.6	1.7	3.7	1.9	-1.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.3	-1.5	0.8	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.4	0.0	-0.5
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.3	0.4	-0.1
Medication: Paracetamol	0.1	0.2	0.4	-0.2	0.6	0.3
Headache pain in last month	0.5	0.9	1.9	-0.8	1.4	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.1	0.0	0.1	1.1
Glaucoma (self-reported)	0.5	0.6	0.9	-0.7	0.6	0.9
Gout (self-reported)	2.1	2.8	3.1	-1.6	1.8	-1.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.1	0.9	-0.3	1.1
Medication: Amlodipine	0.1	0.2	0.2	0.3	-0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.4	0.0	0.3	1.6
Birth weight	0.9	1.9	3.2	-1.5	1.8	0.4
Chronic bronchitis/emphysema (mother)	2.5	2.9	4.5	0.5	-2.1	-2.0
High blood pressure (siblings)	0.3	0.4	0.6	-0.7	0.7	0.2
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.6	0.3	-0.9
Body fat percentage	0.5	1.8	3.0	-1.7	1.6	-0.1
Leg fat percentage (right)	1.0	3.5	5.5	-2.4	2.2	-0.2
Arm fat-free mass (right)	2.2	11.2	18.2	-3.9	4.3	-0.7
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.4	-0.2	-0.1
Comparative body size at age 10	0.8	2.2	3.9	-2.0	0.6	-1.5
Number of full brothers	0.6	0.7	2.0	-0.3	-0.0	1.4
Worry too long after embarrassment	0.2	0.3	0.6	0.8	0.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.1	0.2	-1.5	-1.8
Wheeze or whistling in the chest in last year	0.7	1.2	2.3	-0.5	1.0	1.5
Number of children fathered	2.6	2.9	4.5	1.7	-2.1	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.2	-0.1	-0.1
Age at first live birth	0.7	1.2	1.7	-0.9	1.3	1.1
Pulse wave peak to peak time	0.1	0.1	0.2	0.0	0.1	0.4
Health satisfaction	1.3	1.6	3.0	-0.1	1.7	1.4
Shortness of breath walking on level ground	0.7	0.8	1.9	1.4	-0.7	-0.0
Qualifications: College or University degree	0.3	1.1	2.1	-0.8	1.5	-0.6
Eye problems/disorders: None of the above	0.1	0.2	0.5	0.2	-0.0	0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.3	-1.2	0.3	0.9
Emphysema/chronic bronchitis	0.8	0.9	2.2	-0.5	0.4	-1.5
Medication for pain relief, constipation, heartburn	0.3	0.6	1.5	0.4	-1.2	0.3
Neck or shoulder pain in last month	0.5	0.7	1.5	0.2	0.8	1.2
Medication: Blood pressure	0.1	0.2	0.5	-0.2	-0.1	-0.7
Angina (self-reported)	0.2	0.3	0.5	0.3	-0.4	-0.7
Migraine (self-reported)	0.9	1.1	2.0	-0.7	0.9	1.4
Medication: Ibuprofen	0.9	1.1	1.7	1.3	-0.8	-1.0
Medication: Allopurinol	0.7	0.9	2.1	-0.3	0.7	-1.5
Medication: Omeprazole	0.4	0.4	1.1	0.4	-1.1	-0.1
Medication: Seretide 50 evohaler	0.3	0.4	0.4	-0.7	0.6	0.6
Mean time to correctly identify matches	0.3	0.6	1.7	-0.2	1.3	0.5
Heart disease (mother)	0.7	0.8	1.5	1.2	-0.8	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	0.6	-0.3	0.8
Whole body fat mass	0.9	3.8	6.0	-2.4	2.3	-0.4
Leg fat mass (right)	1.2	4.6	6.9	-2.6	2.6	-0.7
Arm predicted mass (right)	2.4	12.3	19.5	-4.1	4.4	-0.6
Pulse rate, automated reading	0.1	0.3	0.7	0.8	-0.5	-0.2
Alcohol intake frequency.	1.0	2.4	4.4	-0.2	2.1	1.6
Comparative height size at age 10	4.1	22.3	41.7	-4.4	6.5	2.4
Number of full sisters	1.2	1.4	2.6	1.6	-0.5	1.2
Suffer from ‘nerves’	0.6	1.0	1.3	0.8	-1.1	-1.0
Overall health rating	0.2	0.4	0.7	0.6	-0.4	0.8
Chest pain or discomfort	0.9	1.3	2.5	1.6	-0.9	0.7
Had major operations	1.4	1.6	3.1	1.8	-0.9	-0.9
Age at last live birth	0.7	1.0	2.6	-0.3	1.6	0.5
Family relationship satisfaction	0.7	0.9	2.6	0.1	1.6	-0.4
Leg pain on walking	0.9	1.2	2.4	-0.4	1.5	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.7	1.2	-1.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	-0.8	0.3	-1.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.4	0.5	-0.5
Medication: Aspirin	1.6	2.1	3.2	-1.7	1.8	-0.3
Supplements: Vitamin C	0.2	0.2	0.2	0.5	-0.5	-0.5
Knee pain experienced in last month	0.1	0.2	0.3	0.6	-0.1	0.5
Hypertension (Self-reported)	0.3	1.0	1.7	-1.0	0.5	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.0	0.7	0.4
Illnesses of father: Heart disease	0.4	0.5	1.4	0.2	0.4	1.2
Illnesses of siblings: Diabetes	1.6	1.9	4.9	-0.9	2.2	0.3
Smoking status: Previous	0.7	1.1	1.9	0.2	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	9.2	-1.8	3.0	0.1
Whole body fat-free mass	1.8	10.1	17.9	-3.5	4.2	-0.7
Leg fat-free mass (right)	1.1	5.9	8.6	-2.9	2.9	-0.8
Arm fat percentage (left)	0.1	0.5	0.8	-0.9	0.6	-0.6
Average weekly red wine intake	0.8	1.2	3.5	-0.4	0.4	1.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.2	0.4	-0.5
Mood swings	1.4	2.5	5.9	1.1	-0.7	-2.4
Loneliness, isolation	0.4	0.5	1.0	1.0	0.2	-0.7
Long-standing illness, disability or infirmity	0.3	0.5	1.0	-0.1	0.7	-1.0
Ever had bowel cancer screening	1.7	2.0	4.6	-0.9	0.8	2.1
Diabetes diagnosed by doctor	0.8	1.4	2.3	-1.1	1.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	0.1	-0.7	-0.8
Friendships satisfaction	0.8	0.9	2.6	0.2	1.6	-0.5
Qualifications: nursing, teaching	1.6	2.5	3.6	-0.9	1.8	1.9
Commuting to job workplace: Walk	0.7	0.7	1.2	-1.1	0.8	-0.6
Eye problems/disorders: Cataract	0.2	0.3	0.7	-0.3	0.9	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.7	-0.6	2.2	1.3
Medication for cholesterol	0.3	0.4	1.0	-0.4	1.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.0	-1.0	0.1	-0.8
Back pain experienced in last month	0.1	0.1	0.3	0.2	0.2	0.6
Mineral and other dietary supplements	0.1	0.1	0.3	-0.3	0.5	-0.1
Breast cancer (self-reported)	0.9	1.1	2.2	0.2	-1.5	-1.0
Asthma (self-reported)	0.3	0.7	1.9	0.3	-0.1	1.4
Osteoporosis (self-reported)	0.7	0.9	2.4	-1.6	0.1	-0.5
Osteoarthritis (self-reported)	0.5	0.6	0.9	-0.7	0.9	0.7
Medication: Aspirin	0.8	1.1	1.7	-1.3	0.9	-0.8
Medication: Gliclazide	0.3	0.4	0.9	-0.2	0.4	0.9
Illnesses of father: None of the above (group 1)	0.7	0.9	1.3	0.8	-0.8	-1.2
Smoking status: Current	0.1	0.1	0.2	-0.0	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.4	7.2	10.7	0.6	-3.2	-3.3
Whole body water mass	1.8	10.0	17.8	-3.4	4.2	-0.7
Leg predicted mass (right)	1.1	6.0	9.0	-2.9	3.0	-0.9
Arm fat mass (left)	0.7	2.8	4.3	-1.9	2.1	-0.6
Number of self-reported non-cancer illnesses	0.8	1.4	2.5	-1.6	1.3	-0.1
Average weekly champagne plus white wine intake	0.4	0.5	1.1	-0.6	0.2	1.1
Miserableness	0.7	1.1	2.4	-0.0	1.0	-1.6
Guilty feelings	0.3	0.5	0.8	0.2	0.8	0.9
Wears glasses or contact lenses	1.1	1.3	3.5	0.2	-0.6	1.9
Ever taken oral contraceptive pill	1.1	1.2	2.4	0.4	1.1	1.5
Hearing aid user	0.1	0.2	0.3	0.4	-0.6	-0.0
Mother’s age at death	0.0	0.0	0.1	0.0	-0.0	0.4
Financial situation satisfaction	0.5	0.7	1.3	1.1	-0.8	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	-0.7	0.9	-0.2
Commuting to job workplace: Public transport	0.8	0.9	2.0	0.5	-1.4	0.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	0.2	-0.3	-0.3
Medication: Blood pressure	0.0	0.1	0.1	0.2	0.3	0.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.9	-2.0	0.2	-0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.2	0.5	-1.1	-0.5
High cholesterol (Self-reported)	0.8	1.5	1.8	-1.1	1.1	1.3
Medication: Bendroflumethiazide	0.3	0.5	1.4	-0.3	1.2	-0.2
Medication: Paracetamol	0.2	0.3	0.7	0.9	0.5	0.2
Medication: Lisinopril	0.3	0.4	0.4	-0.7	-0.4	-0.7
Medication: Atorvastatin	1.1	1.4	3.8	-0.1	-0.6	-2.0
Illnesses of father: High blood pressure	0.8	1.0	2.0	-1.4	0.8	0.5
Alcohol drinker status: Never	0.3	0.4	0.7	0.8	0.6	0.2
Ever smoked	0.2	0.3	0.3	0.5	-0.6	0.6
Basal metabolic rate	1.8	10.2	18.6	-3.4	4.3	-0.6
Leg fat percentage (left)	0.8	3.1	5.1	-2.3	2.0	-0.3
Arm fat-free mass (left)	2.0	10.2	18.7	-3.4	4.3	-0.7
Number of operations (self-reported)	0.7	1.1	1.7	1.3	-1.2	-0.1
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.3	-0.6	-0.8
Irritability	0.4	0.7	1.3	1.1	-0.8	-0.4
Risk taking	0.1	0.1	0.2	0.1	-0.3	0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.1	0.7	-1.4	0.4
Fractured/broken bones in last 5 years	0.5	0.6	1.6	-1.3	0.1	-0.4
Age started oral contraceptive pill	2.0	2.5	3.6	-1.7	0.8	1.9
Diastolic blood pressure, automated reading	0.6	1.9	4.0	0.4	-1.2	-2.0
Ever depressed for a whole week	0.6	0.7	1.2	1.0	0.0	1.1
Unable to work because of sickness or disability	0.4	0.6	1.5	0.3	-1.2	0.3
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.5	0.3	-0.8
Myopia	0.5	0.8	2.1	-0.4	0.2	1.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.3	1.0	-0.8	1.5
Cholesterol lowering medication	0.8	1.2	2.4	-1.5	0.4	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.3	-0.7	0.5
Pain experienced in last month	0.4	0.6	1.4	0.5	-1.2	-0.3
Supplements: Calcium	0.9	0.9	1.7	-1.1	-1.3	-0.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	-0.1	-0.5	1.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.8	-0.6	0.8	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	0.8	-0.1	-0.0
Heart disease (siblings)	0.9	1.2	3.2	-0.5	1.8	0.1
Alcohol drinker status: Previous	0.9	1.0	1.6	0.5	-1.0	-1.3
Pack years of smoking	0.2	0.2	0.7	0.8	-0.2	0.0
Impedance of whole body	0.4	2.1	4.6	1.2	-0.5	2.1
Leg fat mass (left)	1.1	4.4	6.4	-2.5	2.5	-0.7
Arm predicted mass (left)	2.0	10.3	17.6	-3.5	4.2	-0.9