Hub : Genes

IMPG1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0700 0.0380 0.013 0.012 0.007 0.016 0.016 0.020 0.01000 0.037 0.0037 0.0046 0.0015
2 TCGA Lung Adenocarcinoma 0.0491 0.0236 0.007 0.030 0.018 0.017 NA 0.019 0.00019 0.003 0.0038 NA 0.0024
3 TCGA Thyroid Carcinoma 0.0820 0.0360 0.005 0.001 0.008 0.002 NA -0.003 0.22000 0.048 0.2000 NA 0.7900

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.8 1.2 1.9 -0.9 1.4 1.0
Bipolar Disorder or Schizophrenia 0.4 1.1 1.7 -1.3 0.8 0.9
Depressed Affect (Nagel 2018) 0.6 1.2 1.8 1.3 -0.1 -1.3
Depression (Nagel 2018) 1.3 1.9 3.3 -1.1 1.8 1.1
Intelligence (Savage-Jansen 2018) 1.0 3.0 5.4 -1.8 2.3 -0.6
Neuroticism (Nagel 2018) 0.6 1.4 2.4 1.5 -0.5 -1.3
Schizophrenia (2018) 0.2 0.4 1.0 -1.0 -0.1 0.3
Schizophrenia vs Biploar Disorder 1.5 2.0 4.1 2.0 -0.6 1.2
Worry (Nagel 2018) 1.1 2.4 3.1 1.4 -1.4 -1.8
Alzheimer’s Disease (in mother) 0.1 0.1 0.3 0.5 0.0 -0.3
Alzheimer’s Disease (in father) 2.5 2.7 7.7 0.6 -2.8 -0.4
Alzheimer’s Disease (including proxy) 0.5 0.7 1.1 0.4 -1.1 -0.9
Crohns Disease (2017) 0.1 0.2 0.3 0.6 -0.3 0.3
Irritable Bowel Disease (IBD) 0.2 0.5 0.9 0.8 -0.4 0.9
Ulcerative Colitis (UC) 0.3 0.6 0.9 0.8 -0.4 0.9
Major Depression (MDD) 0.6 0.7 1.3 0.3 -1.2 -0.8
Reaction Time 0.7 1.3 3.5 0.3 1.9 0.5
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.4 0.1 0.7 0.1
Breast Cancer 0.2 0.4 0.9 0.6 -0.3 -1.0
Ovarian Cancer 0.9 1.3 2.1 -0.8 1.0 1.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.5 0.8 -0.8 0.1 0.9
Bipolar Disorder (2011) 1.1 1.1 2.1 -0.1 1.4 1.1
Body Mass Index (BMI) (2010) 1.1 1.5 2.7 0.4 -1.4 -1.6
Coronary Artery Disease (CAD) 0.6 0.7 1.2 -0.5 1.1 -0.7
Crohns Disease (2012) 0.5 0.7 1.4 0.9 -1.2 0.2
Mean Putamen Volume 0.7 0.8 2.0 -0.2 -0.5 -1.4
Fasting Glucose 1.8 2.1 3.3 0.3 1.8 1.7
HbA1C 1.4 1.5 2.7 -0.8 1.6 1.1
HDL Cholesterol 0.5 0.9 1.8 -1.3 0.4 -0.8
LDL Cholesterol 1.4 2.3 3.0 1.4 -1.4 -1.7
Lupus 1.3 2.0 2.9 -0.3 -1.7 -1.7
Neuroticism (2016) 0.2 0.4 0.7 -0.1 -0.6 -0.8
Primary Biliary Cirrhosis 0.6 0.9 1.4 0.8 -0.7 -1.2
Rheumatoid Arthritis 0.4 0.6 1.1 -1.1 -0.2 -0.8
Schizophrenia (2014) 0.1 0.1 0.3 0.2 -0.5 0.2
Triglycerides 0.3 0.6 0.9 -0.9 0.8 -0.4
Type 2 Diabetes (T2D) (2012) 1.2 1.4 3.5 -0.6 1.9 -0.5
Ulcerative Colitis 0.5 0.7 1.7 0.6 -1.3 0.4
Blood Eosinophil Count 0.0 0.3 0.7 -0.3 0.0 -0.8
Blood Platelet Count 0.0 0.5 1.4 -0.5 -1.2 0.0
Blood Red Count 0.4 3.5 7.4 -2.7 1.6 0.8
Blood White Count 0.0 0.3 0.6 0.8 -0.3 0.4
Heel T-Score 1.2 9.5 14.4 -2.8 3.8 2.5
BMI 0.1 0.6 1.4 -0.3 -0.4 -1.2
Height 2.8 53.1 85.4 -7.0 9.2 5.0
Waist Hip Ratio (WHR) 0.1 0.6 1.2 -0.6 1.1 0.5
Systolic Blood Pressure 0.8 4.0 11.2 0.5 -0.8 -3.3
Smoking Status 1.2 2.9 5.5 1.0 -2.3 -1.5
Allergy or Eczema 0.8 2.1 5.5 0.7 -0.6 2.4
Cardiovascular Disease 0.3 0.9 2.5 -0.3 -0.2 -1.6
Hypothyroidism (self reported) 0.1 0.3 0.4 0.5 -0.4 0.7
Respiratory disease 0.6 1.2 2.7 -0.2 0.9 1.7
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.9 -0.9 1.7 0.0
Lung FEV1/FVC ratio 1.6 8.2 14.3 1.8 -2.7 -3.8
Lung FVC 1.4 7.1 10.6 0.6 -3.3 -3.2
Neuroticism 1.1 2.6 4.5 1.7 -0.5 -2.1
Chronotype (morning person) 0.6 1.3 2.5 0.6 -1.1 -1.6
Hair Pigment 0.1 1.5 2.6 -1.2 1.6 0.6
Tanning 0.0 0.6 0.9 0.8 -1.0 -0.3
Hand grip strength (left) 0.2 0.5 0.7 0.6 -0.6 -0.8
Number of treatments/medications taken 0.0 0.0 0.1 0.2 0.2 -0.3
Average weekly spirits intake 0.3 0.3 1.0 -0.0 0.2 -1.0
Sensitivity / hurt feelings 0.4 0.6 1.2 1.1 -0.8 -0.1
Frequency of depressed mood in last 2 weeks 1.0 1.4 2.0 -1.4 1.2 -0.9
Hearing difficulty/problems: Yes 0.2 0.3 0.9 0.1 0.0 0.9
Relative age of first facial hair 0.6 1.2 3.5 0.2 -1.9 0.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.7 1.3 0.2 0.1
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.0 -1.4 -0.9 -0.2
Ever had hysterectomy (womb removed) 0.0 0.0 0.1 -0.1 -0.3 -0.2
Systolic blood pressure, automated reading 0.4 1.2 3.3 -0.2 -0.5 -1.8
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 0.7 0.8 0.4 0.8
Angina 0.2 0.2 0.3 0.5 -0.4 -0.6
Medication for hormone replacement therapy 1.7 1.9 3.9 0.3 -2.0 -1.3
Vitamin and mineral supplements 0.1 0.2 0.2 0.4 -0.4 0.5
Supplements: Zinc 1.0 1.1 2.5 -1.6 0.9 -0.0
Medication: Co-codamol 0.5 0.5 1.4 -1.2 0.4 0.0
Medication: Metformin 2.1 2.9 4.4 -1.8 2.1 1.0
Diabetes (father) 0.9 1.1 2.2 1.5 -1.1 0.3
Diabetes (mother) 0.4 0.6 1.7 0.1 0.1 1.3
Severe depression (siblings) 0.0 0.0 0.0 -0.0 -0.1 -0.0
Pack years adult smoking proportion 0.4 0.5 1.0 1.0 -0.5 -0.6
Impedance of leg (right) 0.4 2.1 4.4 -0.1 1.4 2.1
Leg fat-free mass (left) 1.3 7.1 10.3 -3.2 3.1 -1.0
Trunk fat percentage 0.4 1.7 2.9 -1.7 1.5 0.2
Hand grip strength (right) 0.4 1.1 1.7 0.8 -1.0 -1.3
Townsend deprivation index at recruitment 0.7 0.9 1.6 1.3 -0.8 -0.7
Current tobacco smoking 0.0 0.1 0.2 -0.0 -0.4 -0.2
Average weekly fortified wine intake 1.4 1.6 3.5 -1.9 -0.2 1.1
Maternal smoking around birth 1.9 2.7 4.8 1.1 -1.5 -2.2
Fed-up feelings 0.7 1.2 2.3 1.1 -0.5 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 2.8 3.7 4.7 -2.1 2.2 1.3
Relative age voice broke 1.6 2.4 7.2 0.2 -2.7 0.1
Taking other prescription medications 0.0 0.0 0.1 -0.3 0.1 0.0
Age when periods started (menarche) 0.4 1.0 2.4 0.8 -1.6 -0.2
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 2.4 0.6 -1.5 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.3 0.6 -0.4 0.5 0.8
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 -0.3 0.6 0.2
Qualifications: CSEs or equivalent 1.0 1.3 1.8 0.6 -1.4 -1.4
Serious illness, injury or assault to yourself 1.4 1.7 4.8 -0.2 0.5 2.2
High blood pressure 0.5 1.3 2.1 -1.1 0.7 -1.4
Hayfever, allergic rhinitis or eczema 1.4 3.0 3.6 1.9 -1.4 1.9
Multivitamins +/- minerals 0.2 0.2 0.6 -0.0 0.2 -0.8
Stomach or abdominal pain in last month 1.0 1.2 1.9 0.7 1.1 1.4
Supplements: Glucosamine 0.2 0.2 0.4 0.6 -0.3 0.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 -0.4 0.8 -0.1
Medication: Atenolol 0.5 0.6 1.0 -0.5 1.0 0.7
Medication: Levothyroxine sodium 0.1 0.2 0.3 -0.5 0.1 0.6
Sitting height 0.8 5.8 10.3 -2.0 3.2 1.7
Chronic bronchitis/emphysema (father) 0.4 0.5 0.7 -0.7 0.5 -0.8
High blood pressure (mother) 1.1 1.6 3.2 1.8 -0.7 -1.0
Body mass index (BMI) 0.5 2.0 2.2 -1.5 1.2 -1.5
Impedance of leg (left) 0.4 1.9 4.6 0.3 1.0 2.1
Leg predicted mass (left) 1.3 7.1 10.3 -3.2 3.2 -0.9
Trunk fat mass 1.0 4.2 6.5 -2.5 2.5 0.0
Waist circumference 1.2 4.3 7.3 -2.4 2.7 -0.1
Number of incorrect matches in round 0.4 0.6 0.9 0.6 -0.7 1.0
Past tobacco smoking 0.3 0.6 1.4 -0.1 1.2 0.6
Alcohol usually taken with meals 1.0 1.6 2.6 -1.3 0.5 1.6
Nervous feelings 0.4 0.7 1.1 0.5 -0.8 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.9 -0.6 -0.1 -1.0
Hearing difficulty/problems with background noise 0.1 0.1 0.4 0.1 0.1 0.6
Hair/balding pattern: Pattern 2 1.3 1.7 3.8 -0.5 1.0 -1.9
Had menopause 2.0 2.5 5.7 -2.4 0.4 1.3
Had other major operations 1.5 1.8 3.1 1.8 -1.5 0.0
Forced vital capacity (FVC) 0.1 0.5 0.7 -0.6 0.8 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 5.6 -1.6 2.4 0.8
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.8 0.1 -0.2 -0.9
Qualifications: None of the above 0.4 0.9 2.0 0.8 -1.4 -0.3
Financial difficulties in last 2 years 0.6 0.8 1.7 0.7 1.3 0.5
Mouth/teeth dental problems 0.7 1.1 1.7 0.2 -1.2 -1.3
Heart attack 0.6 0.8 1.9 -0.4 0.6 -1.4
Allergy 0.8 1.9 4.8 -0.9 0.3 -2.2
Pain all over the body in last month 0.2 0.2 0.4 0.3 -0.6 -0.2
Diabetes (self-reported) 0.7 1.1 1.9 -0.9 1.4 0.8
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.0 -1.0 -0.2 -0.5
Medication: Ramipril 3.5 4.5 7.2 -2.7 2.5 -0.4
Medication: Simvastatin 1.0 1.4 2.1 -1.0 1.4 1.1
Fluid intelligence score 0.3 0.7 1.5 -0.1 1.2 0.7
Illnesses of siblings 0.5 0.7 0.8 0.8 -0.8 -0.9
Neuroticism score 0.9 1.8 2.4 1.5 -0.8 -1.6
Weight 1.6 7.8 14.1 -3.0 3.8 0.0
Impedance of arm (right) 0.7 3.2 4.7 1.9 -1.2 2.2
Arm fat percentage (right) 0.1 0.4 0.5 -0.6 0.4 -0.7
Trunk fat-free mass 2.0 11.3 21.7 -3.5 4.7 -0.5
Hip circumference 1.9 8.4 14.7 -3.2 3.8 0.5
Time employed in main current job 0.8 0.9 2.3 -0.5 1.5 0.1
Alcohol intake versus 10 years previously 1.0 1.6 4.2 -0.6 2.0 0.4
Father’s age at death 0.1 0.2 0.4 0.3 -0.0 0.6
Worrier / anxious feelings 0.4 0.8 1.3 1.1 -0.8 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 2.3 0.4 1.5 0.2
Falls in the last year 0.6 0.8 1.5 -0.9 0.1 1.2
Hair/balding pattern: Pattern 3 0.7 1.0 2.9 0.5 -0.0 1.7
Number of live births 1.3 1.8 5.3 0.3 -2.3 -0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.7 -0.4 0.0 -1.3
Pulse rate 0.3 0.5 1.0 -0.5 0.5 1.0
Happiness 1.1 1.3 1.7 -1.2 0.9 -1.3
Noisy workplace 0.8 1.0 2.4 0.3 -0.6 -1.6
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.3 0.1 0.5 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.0 -0.5 -1.0 0.4
Mouth/teeth dental problems: Dentures 0.6 1.0 1.5 -1.0 0.7 1.2
Asthma 0.4 0.8 2.3 -0.2 0.3 1.5
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.3 1.1 -0.8 -0.4
Medication: Cholesterol lowering 1.0 1.6 2.5 -1.4 1.6 -0.5
Depression (self-reported) 0.6 0.7 1.9 0.3 -0.5 -1.4
Medication: Lansoprazole 0.7 0.8 2.2 0.0 0.2 1.5
Prospective memory result 1.1 1.4 3.6 -0.6 -1.9 0.4
Lung cancer (father) 1.6 1.8 5.2 -0.5 -0.3 -2.3
Illnesses of mother 1.1 1.3 3.2 -1.8 0.9 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.9 -0.3 -0.1 -1.7
Pulse wave Arterial Stiffness index 0.0 0.0 0.1 -0.2 0.3 0.0
Impedance of arm (left) 0.8 3.6 6.0 1.8 -1.2 2.4
Arm fat mass (right) 0.7 2.7 4.4 -1.8 2.1 -0.6
Trunk predicted mass 1.9 10.9 21.1 -3.3 4.6 -0.6
Standing height 1.8 17.6 31.8 -3.5 5.6 2.9
Length of working week for main job 1.7 1.8 5.5 -0.0 -0.1 -2.4
Exposure to tobacco smoke at home 2.0 2.3 3.6 1.9 -1.5 -0.9
Breastfed as a baby 0.2 0.3 0.4 0.7 0.1 0.6
Tense / ‘highly strung’ 0.4 0.7 1.2 -0.6 -0.7 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.7 4.9 1.3 -2.2 -1.2
Hair/balding pattern: Pattern 4 0.4 1.0 1.8 -0.3 -1.1 -1.3
Birth weight of first child 0.9 1.7 2.4 -1.4 0.9 -1.5
Peak expiratory flow (PEF) 0.1 0.2 0.4 -0.1 0.2 0.7
Pulse wave reflection index 0.8 1.0 1.4 1.2 -1.2 0.4
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.7 0.5 0.8 0.2
Loud music exposure frequency 1.6 1.7 3.7 1.9 -1.2 0.2
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.3 -1.5 0.8 -0.4
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 0.4 0.0 -0.5
Blood clot in the leg (DVT) 0.1 0.1 0.2 0.3 0.4 -0.1
Medication: Paracetamol 0.1 0.2 0.4 -0.2 0.6 0.3
Headache pain in last month 0.5 0.9 1.9 -0.8 1.4 0.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.1 0.0 0.1 1.1
Glaucoma (self-reported) 0.5 0.6 0.9 -0.7 0.6 0.9
Gout (self-reported) 2.1 2.8 3.1 -1.6 1.8 -1.7
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.1 0.9 -0.3 1.1
Medication: Amlodipine 0.1 0.2 0.2 0.3 -0.5 0.5
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.4 0.0 0.3 1.6
Birth weight 0.9 1.9 3.2 -1.5 1.8 0.4
Chronic bronchitis/emphysema (mother) 2.5 2.9 4.5 0.5 -2.1 -2.0
High blood pressure (siblings) 0.3 0.4 0.6 -0.7 0.7 0.2
Forced vital capacity (FVC), Best measure 0.1 0.4 0.8 -0.6 0.3 -0.9
Body fat percentage 0.5 1.8 3.0 -1.7 1.6 -0.1
Leg fat percentage (right) 1.0 3.5 5.5 -2.4 2.2 -0.2
Arm fat-free mass (right) 2.2 11.2 18.2 -3.9 4.3 -0.7
Exposure to tobacco smoke outside home 0.1 0.1 0.2 0.4 -0.2 -0.1
Comparative body size at age 10 0.8 2.2 3.9 -2.0 0.6 -1.5
Number of full brothers 0.6 0.7 2.0 -0.3 -0.0 1.4
Worry too long after embarrassment 0.2 0.3 0.6 0.8 0.1 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 3.1 0.2 -1.5 -1.8
Wheeze or whistling in the chest in last year 0.7 1.2 2.3 -0.5 1.0 1.5
Number of children fathered 2.6 2.9 4.5 1.7 -2.1 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.0 0.2 -0.1 -0.1
Age at first live birth 0.7 1.2 1.7 -0.9 1.3 1.1
Pulse wave peak to peak time 0.1 0.1 0.2 0.0 0.1 0.4
Health satisfaction 1.3 1.6 3.0 -0.1 1.7 1.4
Shortness of breath walking on level ground 0.7 0.8 1.9 1.4 -0.7 -0.0
Qualifications: College or University degree 0.3 1.1 2.1 -0.8 1.5 -0.6
Eye problems/disorders: None of the above 0.1 0.2 0.5 0.2 -0.0 0.7
Mouth/teeth dental problems: Loose teeth 0.6 0.8 1.3 -1.2 0.3 0.9
Emphysema/chronic bronchitis 0.8 0.9 2.2 -0.5 0.4 -1.5
Medication for pain relief, constipation, heartburn 0.3 0.6 1.5 0.4 -1.2 0.3
Neck or shoulder pain in last month 0.5 0.7 1.5 0.2 0.8 1.2
Medication: Blood pressure 0.1 0.2 0.5 -0.2 -0.1 -0.7
Angina (self-reported) 0.2 0.3 0.5 0.3 -0.4 -0.7
Migraine (self-reported) 0.9 1.1 2.0 -0.7 0.9 1.4
Medication: Ibuprofen 0.9 1.1 1.7 1.3 -0.8 -1.0
Medication: Allopurinol 0.7 0.9 2.1 -0.3 0.7 -1.5
Medication: Omeprazole 0.4 0.4 1.1 0.4 -1.1 -0.1
Medication: Seretide 50 evohaler 0.3 0.4 0.4 -0.7 0.6 0.6
Mean time to correctly identify matches 0.3 0.6 1.7 -0.2 1.3 0.5
Heart disease (mother) 0.7 0.8 1.5 1.2 -0.8 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.7 0.6 -0.3 0.8
Whole body fat mass 0.9 3.8 6.0 -2.4 2.3 -0.4
Leg fat mass (right) 1.2 4.6 6.9 -2.6 2.6 -0.7
Arm predicted mass (right) 2.4 12.3 19.5 -4.1 4.4 -0.6
Pulse rate, automated reading 0.1 0.3 0.7 0.8 -0.5 -0.2
Alcohol intake frequency. 1.0 2.4 4.4 -0.2 2.1 1.6
Comparative height size at age 10 4.1 22.3 41.7 -4.4 6.5 2.4
Number of full sisters 1.2 1.4 2.6 1.6 -0.5 1.2
Suffer from ‘nerves’ 0.6 1.0 1.3 0.8 -1.1 -1.0
Overall health rating 0.2 0.4 0.7 0.6 -0.4 0.8
Chest pain or discomfort 0.9 1.3 2.5 1.6 -0.9 0.7
Had major operations 1.4 1.6 3.1 1.8 -0.9 -0.9
Age at last live birth 0.7 1.0 2.6 -0.3 1.6 0.5
Family relationship satisfaction 0.7 0.9 2.6 0.1 1.6 -0.4
Leg pain on walking 0.9 1.2 2.4 -0.4 1.5 1.0
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 1.7 1.2 -1.3 -0.6
Commuting to job workplace: Car/motor vehicle 0.5 0.6 0.9 -0.8 0.3 -1.0
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.3 -0.4 0.5 -0.5
Medication: Aspirin 1.6 2.1 3.2 -1.7 1.8 -0.3
Supplements: Vitamin C 0.2 0.2 0.2 0.5 -0.5 -0.5
Knee pain experienced in last month 0.1 0.2 0.3 0.6 -0.1 0.5
Hypertension (Self-reported) 0.3 1.0 1.7 -1.0 0.5 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 -0.0 0.7 0.4
Illnesses of father: Heart disease 0.4 0.5 1.4 0.2 0.4 1.2
Illnesses of siblings: Diabetes 1.6 1.9 4.9 -0.9 2.2 0.3
Smoking status: Previous 0.7 1.1 1.9 0.2 -1.4 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.1 9.2 -1.8 3.0 0.1
Whole body fat-free mass 1.8 10.1 17.9 -3.5 4.2 -0.7
Leg fat-free mass (right) 1.1 5.9 8.6 -2.9 2.9 -0.8
Arm fat percentage (left) 0.1 0.5 0.8 -0.9 0.6 -0.6
Average weekly red wine intake 0.8 1.2 3.5 -0.4 0.4 1.9
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.2 0.4 -0.5
Mood swings 1.4 2.5 5.9 1.1 -0.7 -2.4
Loneliness, isolation 0.4 0.5 1.0 1.0 0.2 -0.7
Long-standing illness, disability or infirmity 0.3 0.5 1.0 -0.1 0.7 -1.0
Ever had bowel cancer screening 1.7 2.0 4.6 -0.9 0.8 2.1
Diabetes diagnosed by doctor 0.8 1.4 2.3 -1.1 1.5 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.6 0.1 -0.7 -0.8
Friendships satisfaction 0.8 0.9 2.6 0.2 1.6 -0.5
Qualifications: nursing, teaching 1.6 2.5 3.6 -0.9 1.8 1.9
Commuting to job workplace: Walk 0.7 0.7 1.2 -1.1 0.8 -0.6
Eye problems/disorders: Cataract 0.2 0.3 0.7 -0.3 0.9 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 4.7 -0.6 2.2 1.3
Medication for cholesterol 0.3 0.4 1.0 -0.4 1.0 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.0 -1.0 0.1 -0.8
Back pain experienced in last month 0.1 0.1 0.3 0.2 0.2 0.6
Mineral and other dietary supplements 0.1 0.1 0.3 -0.3 0.5 -0.1
Breast cancer (self-reported) 0.9 1.1 2.2 0.2 -1.5 -1.0
Asthma (self-reported) 0.3 0.7 1.9 0.3 -0.1 1.4
Osteoporosis (self-reported) 0.7 0.9 2.4 -1.6 0.1 -0.5
Osteoarthritis (self-reported) 0.5 0.6 0.9 -0.7 0.9 0.7
Medication: Aspirin 0.8 1.1 1.7 -1.3 0.9 -0.8
Medication: Gliclazide 0.3 0.4 0.9 -0.2 0.4 0.9
Illnesses of father: None of the above (group 1) 0.7 0.9 1.3 0.8 -0.8 -1.2
Smoking status: Current 0.1 0.1 0.2 -0.0 -0.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.4 7.2 10.7 0.6 -3.2 -3.3
Whole body water mass 1.8 10.0 17.8 -3.4 4.2 -0.7
Leg predicted mass (right) 1.1 6.0 9.0 -2.9 3.0 -0.9
Arm fat mass (left) 0.7 2.8 4.3 -1.9 2.1 -0.6
Number of self-reported non-cancer illnesses 0.8 1.4 2.5 -1.6 1.3 -0.1
Average weekly champagne plus white wine intake 0.4 0.5 1.1 -0.6 0.2 1.1
Miserableness 0.7 1.1 2.4 -0.0 1.0 -1.6
Guilty feelings 0.3 0.5 0.8 0.2 0.8 0.9
Wears glasses or contact lenses 1.1 1.3 3.5 0.2 -0.6 1.9
Ever taken oral contraceptive pill 1.1 1.2 2.4 0.4 1.1 1.5
Hearing aid user 0.1 0.2 0.3 0.4 -0.6 -0.0
Mother’s age at death 0.0 0.0 0.1 0.0 -0.0 0.4
Financial situation satisfaction 0.5 0.7 1.3 1.1 -0.8 0.1
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.8 -0.7 0.9 -0.2
Commuting to job workplace: Public transport 0.8 0.9 2.0 0.5 -1.4 0.7
Eye problems/disorders: Glaucoma 0.1 0.1 0.1 0.2 -0.3 -0.3
Medication: Blood pressure 0.0 0.1 0.1 0.2 0.3 0.2
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.9 -2.0 0.2 -0.4
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.2 0.5 -1.1 -0.5
High cholesterol (Self-reported) 0.8 1.5 1.8 -1.1 1.1 1.3
Medication: Bendroflumethiazide 0.3 0.5 1.4 -0.3 1.2 -0.2
Medication: Paracetamol 0.2 0.3 0.7 0.9 0.5 0.2
Medication: Lisinopril 0.3 0.4 0.4 -0.7 -0.4 -0.7
Medication: Atorvastatin 1.1 1.4 3.8 -0.1 -0.6 -2.0
Illnesses of father: High blood pressure 0.8 1.0 2.0 -1.4 0.8 0.5
Alcohol drinker status: Never 0.3 0.4 0.7 0.8 0.6 0.2
Ever smoked 0.2 0.3 0.3 0.5 -0.6 0.6
Basal metabolic rate 1.8 10.2 18.6 -3.4 4.3 -0.6
Leg fat percentage (left) 0.8 3.1 5.1 -2.3 2.0 -0.3
Arm fat-free mass (left) 2.0 10.2 18.7 -3.4 4.3 -0.7
Number of operations (self-reported) 0.7 1.1 1.7 1.3 -1.2 -0.1
Average weekly beer plus cider intake 0.2 0.3 0.6 -0.3 -0.6 -0.8
Irritability 0.4 0.7 1.3 1.1 -0.8 -0.4
Risk taking 0.1 0.1 0.2 0.1 -0.3 0.5
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.1 0.7 -1.4 0.4
Fractured/broken bones in last 5 years 0.5 0.6 1.6 -1.3 0.1 -0.4
Age started oral contraceptive pill 2.0 2.5 3.6 -1.7 0.8 1.9
Diastolic blood pressure, automated reading 0.6 1.9 4.0 0.4 -1.2 -2.0
Ever depressed for a whole week 0.6 0.7 1.2 1.0 0.0 1.1
Unable to work because of sickness or disability 0.4 0.6 1.5 0.3 -1.2 0.3
Commuting to job workplace: Cycle 0.3 0.3 0.6 0.5 0.3 -0.8
Myopia 0.5 0.8 2.1 -0.4 0.2 1.4
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.3 1.0 -0.8 1.5
Cholesterol lowering medication 0.8 1.2 2.4 -1.5 0.4 1.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.5 -0.3 -0.7 0.5
Pain experienced in last month 0.4 0.6 1.4 0.5 -1.2 -0.3
Supplements: Calcium 0.9 0.9 1.7 -1.1 -1.3 -0.1
Basal cell carcinoma (self-reported) 0.6 0.7 1.9 -0.1 -0.5 1.4
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.8 -0.6 0.8 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.7 0.8 -0.1 -0.0
Heart disease (siblings) 0.9 1.2 3.2 -0.5 1.8 0.1
Alcohol drinker status: Previous 0.9 1.0 1.6 0.5 -1.0 -1.3
Pack years of smoking 0.2 0.2 0.7 0.8 -0.2 0.0
Impedance of whole body 0.4 2.1 4.6 1.2 -0.5 2.1
Leg fat mass (left) 1.1 4.4 6.4 -2.5 2.5 -0.7
Arm predicted mass (left) 2.0 10.3 17.6 -3.5 4.2 -0.9