TWAS hub - TMEM181

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.3210	0.1520	0.00920	-0.005	NA	0.041	NA	0.010	4.8e-01	NA	2.8e-02	NA	1.7e-01
2	GTEx	Esophagus Muscularis	0.1830	0.0530	0.00015	0.164	NA	0.109	NA	0.138	3.3e-10	NA	3.7e-07	NA	1.0e-08
3	GTEx	Heart Atrial Appendage	0.1620	0.0630	0.00170	0.046	NA	0.039	NA	0.041	3.8e-03	NA	7.1e-03	NA	6.0e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0456	0.0232	0.00250	0.001	0.012	0.004	NA	0.001	2.2e-01	0.01300	9.7e-02	NA	2.3e-01
5	TCGA	Brain Lower Grade Glioma	0.0565	0.0287	0.00680	0.002	0.026	0.004	NA	0.005	1.7e-01	0.00055	1.1e-01	NA	8.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Crohns Disease (2012)	2.6	4.1	11.2	-1.1	1.1	3.3	-1.0	2.5
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	4.0	-1.7	0.3	-2.0	1.8	-1.8
Commuting to job workplace: Car/motor vehicle	2.3	2.7	4.5	-1.4	-1.8	-0.6	-1.9	2.1
Knee pain experienced in last month	2.2	3.5	11.4	1.3	-3.4	-1.1	-1.4	-1.0
Gout (self-reported)	2.1	2.9	6.6	1.4	1.5	0.3	2.6	-1.9
Medication: Amlodipine	2.1	3.0	5.1	2.1	2.1	0.6	2.3	-0.6
Unable to work because of sickness or disability	2.1	2.7	6.1	2.2	2.5	0.6	1.0	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	4.4	1.8	-0.6	-0.6	-2.1	1.9
Ever highly irritable/argumentative for 2 days	1.9	2.2	5.4	-0.9	-2.3	-0.9	-2.0	0.4
Had major operations	1.9	2.3	3.9	2.0	0.7	0.5	-1.7	2.0
Family relationship satisfaction	1.9	2.3	7.7	-1.5	-1.0	-2.8	0.4	-0.5
Loud music exposure frequency	1.8	2.0	3.0	1.4	1.1	1.7	-1.7	1.0
Glaucoma (self-reported)	1.8	2.1	4.9	0.3	-0.2	2.2	-1.3	-1.9
Illnesses of father: Heart disease	1.8	2.4	4.1	-1.9	0.1	2.0	-2.0	0.9
Medication for hormone replacement therapy	1.7	1.9	5.0	-2.2	0.8	-1.6	0.9	-0.4
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	6.0	-0.1	-0.3	-1.2	1.2	-2.4
Suffer from ‘nerves’	1.7	2.7	9.7	-1.0	-1.1	-3.1	0.9	-0.9
Illnesses of father: None of the above (group 1)	1.7	2.1	5.9	0.5	0.8	-0.6	2.4	-1.8
Fed-up feelings	1.6	2.9	6.7	-2.6	-1.2	-1.9	0.2	-1.6
Pain all over the body in last month	1.6	1.8	4.5	1.6	2.1	-0.3	0.7	1.0
Eye problems/disorders: None of the above	1.6	1.8	4.2	-2.0	1.8	0.0	0.6	1.2
Mouth/teeth dental problems: Loose teeth	1.6	1.9	5.1	0.0	-0.5	0.5	-2.3	2.0
Emphysema/chronic bronchitis	1.6	1.9	4.6	1.8	0.8	0.6	-0.6	2.1
Neck or shoulder pain in last month	1.6	2.3	5.9	-1.1	-1.9	-0.3	-2.4	0.9
Age at last live birth	1.6	2.3	7.2	1.0	-0.7	0.8	-1.6	2.7
Crohns Disease (2017)	1.5	3.4	7.6	-2.0	1.7	2.7	-0.5	1.5
Age at First Birth	1.5	2.2	5.8	0.6	-2.4	-0.4	-2.0	0.8
Primary Biliary Cirrhosis	1.5	2.2	4.6	-2.1	0.9	2.0	0.1	-1.3
Severe depression (siblings)	1.5	1.7	4.7	-0.1	1.8	2.2	-0.5	-0.0
Maternal smoking around birth	1.5	2.1	4.7	0.2	-1.6	-2.2	-1.8	0.2
Mouth/teeth dental problems: Dentures	1.5	2.6	10.2	0.9	-0.6	-3.2	0.6	-1.1
Lung cancer (father)	1.5	1.8	4.8	0.6	-2.2	-1.3	-0.3	-1.4
Peak expiratory flow (PEF)	1.5	3.5	9.6	1.9	3.1	0.2	0.5	2.0
Mood swings	1.5	2.7	6.6	-0.3	0.1	-2.6	1.8	-1.8
Alcohol usually taken with meals	1.4	2.2	6.4	-0.6	0.1	1.8	-1.0	2.5
Pulse wave peak to peak time	1.4	1.6	4.7	2.2	0.5	0.6	0.3	1.7
Medication: Seretide 50 evohaler	1.4	1.6	4.3	0.8	2.1	1.4	0.9	0.7
Commuting to job workplace: Public transport	1.4	1.6	3.7	0.3	1.9	0.2	1.6	-1.3
Heart disease (siblings)	1.4	1.7	3.9	0.9	1.6	2.0	0.8	-0.6
Townsend deprivation index at recruitment	1.3	1.8	2.8	1.4	0.6	-1.3	1.4	-1.7
Number of incorrect matches in round	1.3	2.1	4.4	1.5	0.5	-1.9	-0.2	2.1
Number of full brothers	1.3	1.6	2.6	1.1	0.4	-1.6	1.2	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.2	-0.4	-1.8	-1.4	-1.3	-0.3
Eye problems/disorders: Cataract	1.3	1.5	6.4	2.5	-0.9	-0.0	-0.1	-0.4
Relative age of first facial hair	1.2	2.5	5.2	-0.7	-1.5	-2.3	0.4	-2.0
Medication: Co-codamol	1.2	1.4	5.3	2.3	-0.0	1.1	-0.5	0.2
Diabetes (mother)	1.2	1.6	2.7	1.6	-1.6	-1.3	-0.8	0.6
Age when periods started (menarche)	1.2	2.9	10.0	0.9	-1.7	-0.2	0.8	-3.2
Financial difficulties in last 2 years	1.2	1.6	2.9	1.7	0.1	-1.2	1.4	-1.3
Mouth/teeth dental problems	1.2	1.9	6.8	-1.2	1.0	2.6	0.5	0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.1	-1.4	-1.2	-1.4	-1.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.0	-1.3	1.3	-1.4	1.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	6.7	2.6	1.6	0.8	0.3	1.7
Eye problems/disorders: Glaucoma	1.2	1.4	4.5	0.2	-0.0	1.4	-0.7	-2.1
Medication: Blood pressure	1.2	2.3	4.2	2.1	0.1	-0.9	2.0	-1.6
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.1	-1.3	1.8	0.7	1.1	0.5
Fractured/broken bones in last 5 years	1.2	1.5	5.6	2.4	-0.7	-0.2	-0.9	0.8
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.5	1.2	-0.2	1.2	-1.4	1.6
Rheumatoid Arthritis	1.1	1.5	3.6	1.9	-1.1	-1.7	0.3	0.2
Blood White Count	1.1	8.5	26.7	-5.2	2.0	2.8	2.0	-0.2
Ever had hysterectomy (womb removed)	1.1	1.3	4.6	0.0	-0.1	-0.1	1.3	-2.1
Forced vital capacity (FVC)	1.1	4.1	15.0	3.9	1.4	0.0	-1.2	1.4
Falls in the last year	1.1	1.5	5.6	2.4	0.1	-1.1	0.5	-0.5
Pulse wave Arterial Stiffness index	1.1	1.2	3.4	-1.8	-0.3	-0.5	-0.4	-1.5
Medication: Paracetamol	1.1	1.8	3.4	-0.6	-1.8	-1.6	-1.7	0.3
Number of full sisters	1.1	1.3	2.9	-0.6	-1.3	-1.7	-1.0	0.8
Overall health rating	1.1	2.4	8.0	2.8	-0.2	-1.6	1.2	-0.5
Average weekly red wine intake	1.1	1.6	3.3	-1.6	1.0	1.0	0.2	1.8
Medication for cholesterol	1.1	1.7	4.7	-0.2	-0.3	1.1	-2.2	1.5
Osteoporosis (self-reported)	1.1	1.3	3.0	-1.7	-1.1	0.4	-1.5	-0.1
Neuroticism (2016)	1.0	1.5	3.7	-0.8	0.3	-1.9	1.8	-0.3
Respiratory disease	1.0	2.3	5.3	-0.9	2.3	1.7	-0.5	1.5
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.5	1.3	-0.2	-1.9	0.9	-1.1
Current tobacco smoking	1.0	1.6	3.3	1.8	0.4	0.9	-0.5	1.8
Serious illness, injury or assault to yourself	1.0	1.2	1.9	1.3	0.4	1.4	-1.0	1.2
Had other major operations	1.0	1.2	3.0	-1.4	-0.8	-0.2	-1.7	0.6
Noisy workplace	1.0	1.2	4.5	-0.8	0.5	0.3	-2.1	0.6
Forced vital capacity (FVC), Best measure	1.0	3.7	14.0	3.7	1.5	0.7	-0.9	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	5.3	-0.4	-0.2	-0.3	-0.6	2.3
Medication: Allopurinol	1.0	1.4	2.5	1.0	1.6	-0.1	1.4	-1.2
Comparative height size at age 10	1.0	5.4	18.4	4.3	2.3	0.9	-0.2	1.6
Supplements: Vitamin C	1.0	1.2	3.0	-0.8	1.5	1.7	0.4	0.4
Ever had bowel cancer screening	1.0	1.2	2.9	-1.1	-0.3	1.3	-0.4	-1.7
Smoking status: Current	1.0	1.6	4.4	2.1	0.1	0.5	-0.7	1.7
Ever taken oral contraceptive pill	1.0	1.1	3.4	0.2	-0.8	1.9	-0.8	0.8
Illnesses of father: High blood pressure	1.0	1.3	2.9	1.0	-0.9	-1.7	-0.5	1.2
Basal cell carcinoma (self-reported)	1.0	1.1	3.9	0.6	0.7	0.4	-0.9	2.0
Bipolar Disorder (2011)	0.9	0.8	2.8	0.6	0.0	0.8	-1.7	0.6
Fasting Glucose	0.9	1.0	4.8	0.2	-0.1	-2.2	0.5	-0.2
Hearing difficulty/problems: Yes	0.9	1.3	2.7	0.8	-1.4	-1.6	-1.0	-0.6
Hand grip strength (right)	0.9	2.5	6.8	1.2	2.6	1.5	-0.1	1.4
Average weekly fortified wine intake	0.9	1.1	4.0	-2.0	-0.7	0.2	0.7	-0.5
Taking other prescription medications	0.9	1.4	2.7	0.2	0.1	-1.6	1.5	-1.4
Stomach or abdominal pain in last month	0.9	1.1	2.8	0.1	-1.7	0.2	-0.2	-1.5
Had menopause	0.9	1.1	2.3	-1.5	-0.7	-1.5	0.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.3	1.5	-0.2	-1.3	1.4	-1.2
Hair/balding pattern: Pattern 3	0.9	1.3	2.6	1.0	1.6	1.1	1.2	0.4
Exposure to tobacco smoke outside home	0.9	1.2	4.7	2.2	-0.8	0.3	-0.7	0.4
Medication: Omeprazole	0.9	1.0	2.2	0.9	-1.5	-0.3	-1.4	0.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	5.0	-0.5	-0.8	-2.2	-0.6	-1.0
Average weekly beer plus cider intake	0.9	1.3	2.8	-0.7	-1.7	0.1	-0.9	-1.5
Irritability	0.9	1.6	4.5	-0.9	-2.1	-0.5	-1.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.8	0.9	-1.7	-0.3	-1.2	0.3
Bipolar Disorder (2018)	0.8	1.3	2.7	-1.5	-1.6	-1.0	-0.6	-0.3
Schizophrenia vs Biploar Disorder	0.8	1.0	2.1	1.0	1.4	0.5	0.9	1.0
Worry (Nagel 2018)	0.8	1.8	4.9	0.1	-1.9	-2.2	-0.3	-0.5
Reaction Time	0.8	1.5	2.6	-1.4	-1.1	-1.2	-1.6	0.6
Body Mass Index (BMI) (2010)	0.8	1.0	3.5	-1.0	-0.2	-1.9	0.3	0.8
HbA1C	0.8	0.8	2.3	1.5	1.3	0.4	0.5	0.1
Triglycerides	0.8	1.3	4.2	2.0	-0.8	-1.1	-0.2	0.6
Hand grip strength (left)	0.8	2.2	4.9	0.8	0.9	2.2	-1.3	1.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	4.5	-2.1	-0.6	-0.3	-0.2	-0.5
Supplements: Zinc	0.8	0.8	1.8	-1.0	0.5	1.0	-0.3	1.3
Sitting height	0.8	5.8	18.0	4.2	1.6	0.3	-0.8	2.7
Hearing difficulty/problems with background noise	0.8	1.3	3.4	-0.4	-1.1	-0.2	-1.8	1.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.5	-0.3	0.1	1.2	-1.6	1.1
Trunk fat-free mass	0.8	4.4	7.1	2.7	1.9	1.9	-0.9	2.6
Time employed in main current job	0.8	0.9	1.5	0.8	-0.8	-1.2	-0.9	1.0
Happiness	0.8	0.9	3.6	-0.0	-0.4	-1.9	-0.8	0.5
Trunk predicted mass	0.8	4.7	7.9	2.8	2.0	1.9	-0.9	2.7
Standing height	0.8	7.5	27.8	5.3	2.3	0.4	-0.5	2.0
Exposure to tobacco smoke at home	0.8	0.9	2.8	-0.4	-1.1	-1.7	-0.3	-0.3
Breastfed as a baby	0.8	1.0	2.2	-1.5	0.3	-1.4	0.6	0.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.7	0.7	-0.1	1.9	-0.4	0.3
Medication: Gliclazide	0.8	0.9	3.0	0.7	0.0	-0.2	-0.9	1.7
Number of operations (self-reported)	0.8	1.3	3.6	1.4	-0.0	-1.9	-0.3	0.8
Diastolic blood pressure, automated reading	0.8	2.4	4.7	-1.2	0.1	-2.2	2.0	-1.4
Cholesterol lowering medication	0.8	1.1	2.7	1.5	-0.2	0.0	1.6	-0.9
Alzheimer’s Disease (in mother)	0.7	0.9	2.2	-0.4	1.3	1.5	0.1	0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.9	-1.7	-0.3	-0.7	0.2	0.6
Qualifications: CSEs or equivalent	0.7	0.9	3.9	2.0	-0.5	-0.6	-0.4	0.0
Medication: Atenolol	0.7	0.9	2.6	1.1	-1.6	-0.4	0.4	-0.8
Medication: Ramipril	0.7	0.9	2.4	-0.4	-1.5	-0.9	-0.5	-1.0
Alcohol intake versus 10 years previously	0.7	1.0	1.8	-0.3	-1.3	-1.1	0.2	-1.3
Worrier / anxious feelings	0.7	1.3	2.9	1.0	-0.2	-1.7	1.1	-1.2
Number of live births	0.7	1.0	2.1	0.8	1.4	0.7	1.1	-0.7
Pulse wave reflection index	0.7	0.8	1.2	-1.1	1.1	-0.0	0.9	-0.9
Blood clot in the leg (DVT)	0.7	0.9	2.3	1.5	-0.0	1.0	-0.5	1.1
High blood pressure (siblings)	0.7	1.0	3.8	0.1	-1.1	-0.1	0.5	-1.9
Medication for pain relief, constipation, heartburn	0.7	1.2	1.9	0.5	1.2	1.4	1.3	-0.8
Wears glasses or contact lenses	0.7	0.8	1.4	-0.6	1.1	-1.2	1.2	0.1
Myopia	0.7	1.0	1.6	0.4	1.0	-1.2	1.2	-0.7
Pain experienced in last month	0.7	1.1	2.9	-0.1	1.4	0.8	1.7	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.3	4.7	-2.2	-0.4	-0.7	-1.2	0.0
Ulcerative Colitis	0.6	0.9	3.6	-0.6	0.0	-1.9	0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.4	-0.1	-0.5	-1.6	0.1	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.9	1.1	0.2	-0.6	0.5	-1.4
Supplements: Glucosamine	0.6	0.8	1.4	-0.8	-1.2	-0.8	-0.7	0.9
High blood pressure (mother)	0.6	0.9	2.4	-0.2	-1.1	-1.5	0.9	0.1
Heart attack	0.6	0.8	2.1	1.4	0.2	1.3	-0.4	-0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	6.3	2.5	1.4	-0.5	-0.8	1.1
Prospective memory result	0.6	0.7	1.5	0.7	-1.2	-0.4	-1.2	-0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	0.4	-1.1	0.3	-1.0	1.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.1	0.5	0.3	1.8	0.5	-0.4
Wheeze or whistling in the chest in last year	0.6	1.1	2.6	-1.6	1.4	1.0	0.3	0.2
Age at first live birth	0.6	1.0	1.4	-0.4	-0.9	1.1	-1.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.2	-1.1	-1.0	-0.5	0.5	-1.0
Illnesses of siblings: Diabetes	0.6	0.8	2.5	-0.0	0.4	-1.6	-0.3	1.1
Whole body fat-free mass	0.6	3.6	6.1	2.5	1.8	1.6	-0.6	2.5
Friendships satisfaction	0.6	0.7	2.4	0.8	-0.7	-1.5	0.1	-0.2
Qualifications: nursing, teaching	0.6	0.9	1.4	1.1	-1.0	-1.2	0.6	0.7
Whole body water mass	0.6	3.4	5.7	2.3	1.7	1.6	-0.8	2.4
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.7	0.3	-0.3	0.8	-1.6	-0.2
Medication: Paracetamol	0.6	0.9	2.2	0.0	-1.0	-1.0	-1.5	0.6
Medication: Atorvastatin	0.6	0.7	1.7	-0.3	-0.9	0.8	0.2	-1.3
Age started oral contraceptive pill	0.6	0.7	2.3	-1.5	-0.6	-0.6	0.6	-0.6
Depression (Nagel 2018)	0.5	0.8	1.6	0.9	-0.1	-1.1	0.4	-1.3
Schizophrenia (2018)	0.5	1.0	3.4	-1.9	0.8	-0.0	-1.0	0.3
Ulcerative Colitis (UC)	0.5	0.9	2.3	0.1	-1.3	-0.7	-1.5	0.2
Coronary Artery Disease (CAD)	0.5	0.6	1.4	1.2	0.2	0.6	0.8	-0.7
LDL Cholesterol	0.5	0.8	1.9	0.7	-1.4	0.3	-1.1	0.4
Heel T-Score	0.5	4.1	13.0	-1.7	0.2	-2.0	3.6	-0.7
Height	0.5	9.4	35.3	5.9	2.9	0.0	-0.5	1.8
Smoking Status	0.5	1.2	4.6	2.1	-0.9	-0.4	-0.2	-0.8
Allergy or Eczema	0.5	1.4	3.9	-1.6	-0.7	2.0	-0.2	-0.3
Medication: Metformin	0.5	0.8	1.6	0.3	0.7	1.3	-0.9	0.9
Leg fat-free mass (left)	0.5	2.4	5.2	2.3	1.2	0.8	-0.5	2.1
Leg predicted mass (left)	0.5	2.4	5.0	2.2	1.3	0.9	-0.6	2.1
Hair/balding pattern: Pattern 2	0.5	0.6	2.1	-1.4	0.8	0.0	0.4	-0.5
Allergy	0.5	1.2	5.3	-0.1	0.4	-2.3	0.3	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.1	0.5	-0.4	1.4	-0.3	-0.6
Medication: Lansoprazole	0.5	0.6	2.2	-0.3	0.2	-0.1	0.9	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	6.0	2.4	1.3	-0.2	-0.5	0.6
Headache pain in last month	0.5	0.9	3.9	-0.3	-0.4	-2.0	-0.4	-0.2
Birth weight	0.5	1.0	2.1	0.4	0.7	1.1	-1.5	0.9
Number of children fathered	0.5	0.6	1.9	-0.2	0.8	0.2	-0.5	1.4
Health satisfaction	0.5	0.6	1.2	1.1	-0.2	-0.4	-0.8	1.0
Shortness of breath walking on level ground	0.5	0.6	1.2	-0.6	-0.5	-1.0	-1.1	0.3
Mean time to correctly identify matches	0.5	0.9	2.3	-1.5	-0.2	-1.5	-0.3	-0.0
Arm predicted mass (right)	0.5	2.4	3.6	1.9	1.9	1.4	-0.2	1.7
Chest pain or discomfort	0.5	0.7	2.2	0.9	0.6	-0.2	-0.4	1.5
Leg pain on walking	0.5	0.7	3.1	-0.4	-0.1	-1.8	-0.1	0.2
Leg fat-free mass (right)	0.5	2.7	5.4	2.3	1.5	1.0	-0.4	2.1
Diabetes diagnosed by doctor	0.5	0.8	3.3	1.8	0.2	0.4	0.5	-0.2
Breast cancer (self-reported)	0.5	0.6	1.5	-1.2	0.5	-1.0	0.3	0.5
Leg predicted mass (right)	0.5	2.5	4.9	2.2	1.5	0.9	-0.4	2.1
Medication: Bendroflumethiazide	0.5	0.8	2.4	1.5	-0.7	-0.6	0.9	0.1
Basal metabolic rate	0.5	2.7	5.2	2.0	1.5	1.1	-0.7	2.3
Leg fat percentage (left)	0.5	1.7	6.6	-2.6	0.1	-1.3	0.3	-0.2
Arm fat-free mass (left)	0.5	2.5	5.0	1.4	1.6	1.5	-0.9	2.2
Arm predicted mass (left)	0.5	2.6	5.1	1.5	1.5	1.6	-0.9	2.2
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.7	-1.1	1.3	-0.0	1.9	-0.6
Alzheimer’s Disease (including proxy)	0.4	0.5	1.0	-0.4	1.0	0.9	0.4	0.6
Major Depression (MDD)	0.4	0.5	1.0	0.6	1.0	0.8	0.7	0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.3	-1.5	-1.3	-0.2	0.4	-0.7
Mean Putamen Volume	0.4	0.5	1.1	1.1	0.9	0.2	-0.0	0.7
Neuroticism	0.4	1.0	2.4	1.0	-1.6	-1.3	0.2	-0.3
Hair Pigment	0.4	10.1	20.5	-2.2	-2.4	4.5	-4.4	-0.2
Average weekly spirits intake	0.4	0.5	1.1	-1.0	-0.8	-0.2	0.7	-0.7
Relative age voice broke	0.4	0.6	3.0	0.1	0.2	-1.7	-0.1	-0.3
Past tobacco smoking	0.4	0.7	1.6	-1.2	0.6	-0.3	1.1	-0.4
Nervous feelings	0.4	0.8	2.9	-0.3	-0.8	-1.7	0.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.0	1.4	-0.2	-0.8	-0.2	-0.4
Diabetes (self-reported)	0.4	0.6	2.5	1.6	-0.4	0.3	0.2	0.1
Illnesses of siblings	0.4	0.5	1.2	-0.9	0.7	-0.4	0.2	1.1
Neuroticism score	0.4	0.9	2.0	-0.2	-0.7	-1.4	0.5	-1.2
Pulse rate	0.4	0.7	2.4	0.4	-0.5	0.9	-1.6	0.5
Asthma	0.4	0.7	1.3	-0.9	1.2	1.0	-0.1	0.8
Illnesses of mother	0.4	0.4	1.2	0.1	1.1	0.8	0.5	-0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	-0.8	-0.4	-0.7	1.2	-0.4
Leg fat percentage (right)	0.4	1.5	5.4	-2.3	-0.1	-1.4	0.1	-0.1
Arm fat-free mass (right)	0.4	2.3	3.9	1.8	2.0	1.4	0.2	1.5
Qualifications: College or University degree	0.4	1.4	2.5	-1.4	1.6	0.5	1.3	0.7
Migraine (self-reported)	0.4	0.5	1.2	1.1	-0.6	-0.9	-0.3	-0.2
Pulse rate, automated reading	0.4	1.3	2.5	-1.5	-1.2	-0.4	-1.6	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.0	-0.1	-0.8	0.1	0.7	-1.0
Long-standing illness, disability or infirmity	0.4	0.6	1.4	-0.0	-0.6	-1.2	0.1	-1.2
Asthma (self-reported)	0.4	0.8	1.6	-0.5	1.3	0.9	-0.1	1.0
Osteoarthritis (self-reported)	0.4	0.6	2.8	0.0	-0.1	-1.7	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.3	1.1	0.9	0.5	0.9	-1.1
Average weekly champagne plus white wine intake	0.4	0.5	1.3	-0.9	-0.3	1.1	0.6	0.4
Mother’s age at death	0.4	0.5	1.3	-0.3	-0.1	-1.0	1.2	-0.3
Financial situation satisfaction	0.4	0.5	1.0	-0.3	-0.8	-1.0	-0.8	0.4
Risk taking	0.4	0.6	1.1	1.1	1.0	0.7	0.1	0.4
Supplements: Calcium	0.4	0.4	0.7	-0.7	0.8	0.3	0.5	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.3	1.1	0.4	1.1	-0.2	-0.3
Alzheimer’s Disease (in father)	0.3	0.4	0.9	-0.9	0.4	0.5	0.4	0.6
Irritable Bowel Disease (IBD)	0.3	0.8	1.3	-1.0	0.3	0.8	-1.1	1.1
HDL Cholesterol	0.3	0.5	1.0	-0.7	0.8	0.3	0.6	-1.0
Lupus	0.3	0.4	1.4	0.1	1.2	0.8	0.1	-0.2
Cardiovascular Disease	0.3	1.0	3.9	2.0	-0.1	1.0	0.4	-0.1
Chronotype (morning person)	0.3	0.7	1.8	0.4	-1.1	-0.4	-0.2	-1.4
Number of treatments/medications taken	0.3	0.6	1.4	0.3	-0.9	-1.2	0.2	-0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.4	0.1	1.2	-0.5	0.2	-0.2
Systolic blood pressure, automated reading	0.3	0.8	2.7	-0.4	0.9	0.1	1.6	-0.3
Vitamin and mineral supplements	0.3	0.4	0.9	0.9	-0.9	0.1	0.1	-0.3
Pack years adult smoking proportion	0.3	0.4	1.4	0.4	-0.2	-1.2	-0.1	0.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	-0.7	-1.2	1.0	0.0	-0.5
Multivitamins +/- minerals	0.3	0.4	1.0	-0.5	0.3	-1.0	-0.4	0.6
Medication: Levothyroxine sodium	0.3	0.5	1.3	-0.7	0.4	-1.1	0.3	-0.6
Qualifications: None of the above	0.3	0.6	2.8	-0.2	-0.2	-0.0	-1.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	-0.4	-0.9	0.8	-0.6	0.1
Medication: Simvastatin	0.3	0.4	1.9	1.4	-0.1	0.4	0.2	0.2
Father’s age at death	0.3	0.4	2.0	-1.4	0.1	-0.3	0.1	0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.4	1.6	0.1	0.3	1.0	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.7	-0.8	-0.5	-0.6	0.3	-0.5
Birth weight of first child	0.3	0.5	1.2	1.1	0.8	-0.5	0.7	0.5
Comparative body size at age 10	0.3	0.9	2.9	0.3	0.8	1.7	-0.0	1.0
Worry too long after embarrassment	0.3	0.5	0.7	0.6	-0.7	-0.7	-0.8	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.1	1.0	0.3	1.0	-0.3
Medication: Ibuprofen	0.3	0.3	1.2	-1.1	-0.4	-0.5	0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	0.3	0.6	0.4	1.0	0.5
Loneliness, isolation	0.3	0.4	0.9	0.7	0.1	1.0	-0.8	0.3
Commuting to job workplace: Walk	0.3	0.3	0.7	0.6	0.8	0.0	0.5	-0.3
Guilty feelings	0.3	0.4	0.8	0.7	0.9	0.8	0.4	0.3
Medication: Lisinopril	0.3	0.4	0.9	-0.5	1.0	-0.1	0.8	0.4
Ever smoked	0.3	0.6	1.4	1.2	-0.1	0.8	-0.7	0.5
Alcohol drinker status: Previous	0.3	0.4	0.6	0.7	0.4	-0.7	0.2	-0.8
Pack years of smoking	0.3	0.4	1.5	-0.0	-0.4	-1.2	-0.2	0.5
Neuroticism (Nagel 2018)	0.2	0.6	1.8	0.6	-1.3	-0.5	-0.5	-0.4
Ovarian Cancer	0.2	0.3	1.0	-0.3	-0.0	-0.4	0.5	1.0
Schizophrenia (2014)	0.2	0.5	1.8	-1.3	0.7	-0.3	-0.2	0.2
Blood Eosinophil Count	0.2	1.3	3.0	0.3	0.9	1.7	1.5	-0.6
Blood Red Count	0.2	1.9	3.9	-0.9	-1.9	-2.0	0.7	-0.9
Waist Hip Ratio (WHR)	0.2	0.8	4.1	2.0	0.0	0.0	-0.2	-0.0
Systolic Blood Pressure	0.2	1.1	3.1	1.2	0.6	0.3	1.8	-0.5
Lung FEV1/FVC ratio	0.2	1.2	4.0	-2.0	-1.1	-0.9	-0.1	0.0
Lung FVC	0.2	1.0	3.3	1.4	1.8	-0.1	-0.1	-0.2
Sensitivity / hurt feelings	0.2	0.3	0.8	0.9	0.3	0.0	0.7	-0.2
High blood pressure	0.2	0.5	0.9	0.9	0.1	0.5	0.7	-0.8
Body mass index (BMI)	0.2	0.8	3.2	-1.8	-0.1	-0.5	-0.2	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.5	-0.3	0.0	0.4	-0.4	1.2
Weight	0.2	0.9	2.4	0.8	1.1	-0.3	-0.4	1.5
Impedance of arm (right)	0.2	0.8	1.7	1.3	-0.8	-0.8	-0.4	-0.8
Medication: Cholesterol lowering	0.2	0.2	0.5	0.3	-0.2	0.7	-0.7	0.3
Depression (self-reported)	0.2	0.3	0.4	0.6	-0.4	-0.5	0.5	-0.5
Impedance of arm (left)	0.2	1.0	1.8	1.3	-0.6	-1.3	0.2	-1.1
Length of working week for main job	0.2	0.2	0.6	-0.2	0.8	-0.1	-0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.4	1.2	-0.1	0.5	0.2	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.3	-0.5	-0.2	-1.1	0.5	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.6	-1.3	0.4	-0.4	0.3	-0.3
Body fat percentage	0.2	0.7	2.0	-1.4	-0.2	-1.2	-0.2	-0.1
Medication: Blood pressure	0.2	0.3	0.9	0.4	0.4	0.9	-0.0	0.4
Alcohol intake frequency.	0.2	0.4	1.3	-0.4	-0.2	-1.1	-0.5	-0.5
Medication: Aspirin	0.2	0.2	0.6	0.1	-0.4	0.0	-0.6	0.8
Smoking status: Previous	0.2	0.3	0.6	0.5	-0.6	0.2	-0.8	-0.1
Arm fat percentage (left)	0.2	0.6	1.9	-1.4	-0.3	-1.0	-0.0	-0.1
Back pain experienced in last month	0.2	0.3	1.1	-0.3	-0.3	-1.1	0.2	-0.3
Medication: Aspirin	0.2	0.2	0.9	-0.1	-0.1	0.2	-0.4	1.0
Miserableness	0.2	0.4	0.8	0.9	-0.5	0.5	-0.6	-0.3
Hearing aid user	0.2	0.3	0.8	0.9	0.5	0.5	-0.0	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.6	0.5	0.5	-0.2	-0.8	0.5
High cholesterol (Self-reported)	0.2	0.4	1.5	0.6	-1.2	0.0	-0.4	0.1
Alcohol drinker status: Never	0.2	0.2	0.4	0.5	-0.6	-0.3	-0.6	0.4
Ever depressed for a whole week	0.2	0.2	0.7	0.2	-0.5	0.9	-0.2	-0.3
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.1	-0.0	-0.5	0.8	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	-1.0	0.4	0.0	-0.8	1.0
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	0.2	-0.7	-0.6	-0.1	-0.7
Breast Cancer	0.1	0.4	0.6	-0.4	0.7	-0.8	0.7	-0.0
Blood Platelet Count	0.1	1.2	3.3	0.2	0.5	1.8	1.2	-1.0
BMI	0.1	0.8	1.1	-1.0	-0.6	-1.1	1.0	-0.5
Hypothyroidism (self reported)	0.1	0.2	0.4	-0.6	0.5	-0.3	-0.3	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.9	1.0	-0.3	0.4	0.4	-0.2
Tanning	0.1	1.1	2.6	0.0	1.0	1.6	1.3	-0.2
Diabetes (father)	0.1	0.1	0.3	0.6	0.1	-0.2	-0.3	0.5
Impedance of leg (right)	0.1	0.4	1.1	-0.2	-0.4	-0.7	-0.2	-1.1
Trunk fat percentage	0.1	0.6	1.7	-1.1	-0.1	-1.3	-0.3	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.2	-0.0	0.5	-0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	0.0	0.6	-0.2	0.4	0.6
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	0.1	-0.1	0.5	-0.6	-0.0
Impedance of leg (left)	0.1	0.6	2.1	-0.6	-0.2	-0.8	0.3	-1.5
Trunk fat mass	0.1	0.3	0.7	-0.3	0.3	-0.9	-0.4	0.5
Waist circumference	0.1	0.5	1.2	-0.5	0.6	-1.1	-0.3	0.8
Fluid intelligence score	0.1	0.2	0.4	-0.3	-0.6	0.5	0.2	0.2
Arm fat percentage (right)	0.1	0.5	1.6	-1.3	-0.3	-0.6	-0.4	0.2
Hip circumference	0.1	0.6	1.7	-0.0	0.1	-0.9	-0.7	1.3
Tense / ‘highly strung’	0.1	0.2	0.6	0.3	-0.8	-0.3	-0.2	-0.1
Heart disease (mother)	0.1	0.1	0.4	-0.6	-0.0	-0.3	0.4	-0.3
Whole body fat mass	0.1	0.3	0.8	-0.5	0.2	-0.9	-0.3	0.4
Leg fat mass (right)	0.1	0.4	0.9	-0.9	0.3	-0.9	0.3	0.2
Hypertension (Self-reported)	0.1	0.3	0.7	0.6	-0.0	0.6	0.5	-0.8
Mineral and other dietary supplements	0.1	0.1	0.2	-0.2	0.3	0.0	-0.4	-0.3
Arm fat mass (left)	0.1	0.2	0.5	-0.7	-0.0	-0.6	-0.4	0.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	0.1	-0.3	0.6	0.1	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.0	-0.5	-0.1	-0.1	0.3
Impedance of whole body	0.1	0.7	2.0	0.5	-0.3	-1.1	0.4	-1.4
Leg fat mass (left)	0.1	0.4	1.1	-1.1	0.3	-0.7	0.2	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Angina	0.0	0.0	0.1	0.1	-0.3	-0.1	-0.1	0.1
Arm fat mass (right)	0.0	0.2	0.3	-0.4	-0.0	-0.5	-0.5	0.4
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	-0.3	-0.3	-0.2	-0.0	-0.6
Angina (self-reported)	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1	0.2

Hub : Genes

TMEM181

Models

Trait associations