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chr1:88,453,303-90,179,532

Best TWAS P=7.97e-29 · Best GWAS P=3.19e-32 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
43	GTEx	Stomach	CCBL2	0.16	0.08	lasso	4	0.15	9.0e-08	-9.2	11.1	8.0e-29	-0.88	0.03	0.97	TRUE
2	GTEx	Adipose Subcutaneous	CCBL2	0.26	0.21	enet	15	0.23	1.2e-18	-9.3	10.0	2.1e-23	-0.68	1.00	0.00	TRUE
3	GTEx	Adipose Subcutaneous	RBMXL1	0.10	0.02	lasso	8	0.02	1.4e-02	-4.6	5.3	1.1e-07	-0.16	0.13	0.10	TRUE
24	GTEx	Breast Mammary Tissue (Female)	CCBL2	0.09	0.05	lasso	2	0.04	2.4e-02	-1.3	5.3	1.3e-07	-0.50	0.04	0.25	TRUE
12	GTEx	Brain Cerebellar Hemisphere	CCBL2	0.31	0.18	lasso	5	0.23	1.7e-06	-10.0	11.0	2.8e-28	-0.84	0.22	0.72	FALSE
9	GTEx	Artery Tibial	CCBL2	0.30	0.24	lasso	8	0.29	4.9e-23	-9.2	10.7	6.1e-27	-0.74	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	PKN2	0.05	0.01	enet	8	0.02	1.6e-03	-11.0	-10.7	1.4e-26	0.91	0.02	0.97	FALSE
45	GTEx	Thyroid	CCBL2	0.22	0.15	enet	22	0.22	9.8e-17	-10.0	10.6	2.6e-26	-0.66	1.00	0.00	FALSE
28	GTEx	Colon Transverse	CCBL2	0.30	0.19	lasso	8	0.26	1.2e-12	-9.2	10.5	9.2e-26	-0.75	0.96	0.04	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	CCBL2	0.38	0.44	enet	20	0.32	2.1e-09	-9.2	10.4	2.6e-25	-0.82	0.44	0.56	FALSE
49	METSIM	Adipose	CCBL2	0.27	0.14	lasso	6	0.18	6.4e-27	-9.3	10.3	8.0e-25	-0.75	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	CCBL2	0.21	0.10	enet	7	0.15	5.2e-08	-9.2	10.3	9.5e-25	-0.73	0.89	0.10	FALSE
38	GTEx	Pancreas	CCBL2	0.26	0.21	lasso	4	0.23	5.3e-10	-10.0	10.2	1.3e-24	-0.62	0.76	0.18	FALSE
41	GTEx	Skin Sun Exposed Lower leg	CCBL2	0.18	0.09	enet	12	0.17	4.0e-14	-9.2	10.2	1.7e-24	-0.66	0.88	0.12	FALSE
39	GTEx	Pituitary	CCBL2	0.45	0.30	lasso	2	0.26	2.7e-07	-10.0	10.2	2.2e-24	-0.76	0.75	0.19	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	CCBL2	0.43	0.56	enet	31	0.56	1.1e-87	-9.3	10.2	2.8e-24	-0.79	1.00	0.00	FALSE
7	GTEx	Artery Aorta	CCBL2	0.29	0.20	enet	24	0.24	1.5e-13	-9.2	10.1	3.7e-24	-0.70	0.99	0.01	FALSE
19	GTEx	Brain Putamen basal ganglia	CCBL2	0.35	0.26	enet	21	0.25	1.2e-06	-9.2	10.1	3.7e-24	-0.75	0.09	0.87	FALSE
36	GTEx	Nerve Tibial	CCBL2	0.42	0.33	enet	38	0.38	3.4e-28	-9.2	10.1	5.9e-24	-0.76	1.00	0.00	FALSE
31	GTEx	Esophagus Muscularis	CCBL2	0.25	0.29	enet	18	0.28	1.6e-17	-9.3	10.1	7.9e-24	-0.76	1.00	0.00	FALSE
25	GTEx	Cells Transformed fibroblasts	CCBL2	0.65	0.61	enet	32	0.67	6.1e-67	-9.2	10.0	1.0e-23	-0.74	1.00	0.00	FALSE
33	GTEx	Lung	CCBL2	0.15	0.13	enet	13	0.17	4.8e-13	-9.1	10.0	1.3e-23	-0.70	0.97	0.03	FALSE
14	GTEx	Brain Cortex	CCBL2	0.59	0.39	enet	13	0.37	3.0e-11	-10.0	9.9	3.7e-23	-0.76	0.93	0.07	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCBL2	0.58	0.68	lasso	7	0.69	1.4e-117	-9.2	9.9	4.2e-23	-0.75	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Glioblastoma Multiforme	CCBL2	0.36	0.32	enet	37	0.33	6.4e-11	-9.2	9.9	5.0e-23	-0.67	0.23	0.77	FALSE
13	GTEx	Brain Cerebellum	CCBL2	0.39	0.30	enet	23	0.33	1.7e-10	-9.1	9.8	8.2e-23	-0.65	0.52	0.47	FALSE
15	GTEx	Brain Frontal Cortex BA9	CCBL2	0.47	0.38	enet	25	0.48	1.5e-14	-9.2	9.7	3.1e-22	-0.79	0.79	0.21	FALSE
46	GTEx	Thyroid	RBMXL1	0.09	0.02	enet	19	0.04	2.7e-04	-4.6	9.7	4.4e-22	-0.50	0.16	0.52	FALSE
32	GTEx	Heart Atrial Appendage	CCBL2	0.30	0.20	enet	11	0.15	3.4e-07	-9.3	9.6	6.9e-22	-0.73	0.97	0.03	FALSE
30	GTEx	Esophagus Mucosa	CCBL2	0.35	0.19	enet	27	0.30	2.7e-20	-9.2	9.6	1.3e-21	-0.58	0.98	0.02	FALSE
70	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCBL2	0.37	0.47	enet	19	0.46	3.1e-20	-9.2	9.5	2.1e-21	-0.77	1.00	0.00	FALSE
53	YFS	Blood	GTF2B	0.01	0.00	lasso	3	0.01	2.3e-04	-10.1	-9.4	3.5e-21	0.70	0.20	0.34	FALSE
62	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CCBL2	0.28	0.42	enet	15	0.40	1.5e-24	-9.2	9.4	3.9e-21	-0.74	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	CCBL2	0.45	0.64	enet	13	0.66	1.4e-86	-9.2	9.3	8.5e-21	-0.75	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Soft Tissue Sarcoma	CCBL2	0.28	0.32	enet	21	0.32	8.7e-20	-9.2	9.3	1.1e-20	-0.73	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCBL2	0.37	0.48	enet	20	0.50	1.5e-63	-9.1	9.3	1.5e-20	-0.69	1.00	0.00	FALSE
8	GTEx	Artery Coronary	CCBL2	0.29	0.19	enet	5	0.14	1.6e-05	-9.0	9.3	2.1e-20	-0.72	0.58	0.27	FALSE
44	GTEx	Testis	CCBL2	0.47	0.56	lasso	5	0.57	1.2e-30	-9.2	9.2	2.2e-20	-0.73	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Rectum Adenocarcinoma	CCBL2	0.35	0.27	lasso	6	0.25	1.7e-06	-9.2	9.2	2.2e-20	-0.73	0.33	0.58	FALSE
21	GTEx	Breast Mammary Tissue	CCBL2	0.15	0.11	lasso	5	0.09	1.8e-05	-9.2	9.2	2.4e-20	-0.73	0.73	0.23	FALSE
35	GTEx	Muscle Skeletal	CCBL2	0.12	0.15	enet	9	0.16	5.4e-15	-9.3	9.2	2.4e-20	-0.74	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCBL2	0.20	0.34	lasso	2	0.35	9.5e-38	-9.2	9.2	2.4e-20	-0.74	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCBL2	0.28	0.32	enet	24	0.31	2.5e-35	-9.2	9.2	2.7e-20	-0.68	1.00	0.00	FALSE
22	GTEx	Breast Mammary Tissue (Male)	CCBL2	0.14	0.03	lasso	2	0.02	8.8e-02	-9.2	9.2	3.0e-20	-0.72	0.05	0.30	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCBL2	0.20	0.36	lasso	5	0.36	1.7e-78	-9.1	9.2	3.0e-20	-0.73	1.00	0.00	FALSE
26	GTEx	Colon Sigmoid	CCBL2	0.22	0.12	enet	4	0.09	5.2e-04	-9.1	9.2	3.5e-20	-0.71	0.33	0.39	FALSE
48	GTEx	Whole Blood	CCBL2	0.08	0.07	lasso	3	0.06	3.1e-06	-9.2	9.2	3.5e-20	-0.73	0.88	0.08	FALSE
69	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCBL2	0.15	0.18	lasso	2	0.16	3.5e-07	-9.0	9.0	2.2e-19	-0.69	0.52	0.45	FALSE
74	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CCBL2	0.24	0.20	enet	12	0.17	2.7e-05	-9.2	9.0	2.5e-19	-0.72	0.31	0.18	FALSE
6	GTEx	Adrenal Gland	CCBL2	0.18	0.13	enet	46	0.14	1.4e-05	-10.4	9.0	2.6e-19	-0.65	0.24	0.67	FALSE
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	CCBL2	0.11	0.13	enet	14	0.11	1.7e-08	-9.2	8.9	4.1e-19	-0.71	0.96	0.04	FALSE
4	GTEx	Adipose Visceral Omentum	PKN2	0.09	0.04	enet	8	0.05	1.2e-03	-10.0	-8.9	6.9e-19	0.70	0.31	0.36	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCBL2	0.07	0.06	lasso	2	0.05	1.2e-06	-9.2	8.9	6.9e-19	-0.67	0.34	0.64	FALSE
16	GTEx	Brain Hippocampus	CCBL2	0.39	0.27	lasso	5	0.13	5.1e-04	-9.3	-8.9	7.6e-19	0.69	0.22	0.24	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	PKN2	0.02	0.01	enet	5	0.01	2.3e-03	-9.0	-8.8	1.0e-18	0.66	0.09	0.17	FALSE
11	GTEx	Brain Caudate basal ganglia	CCBL2	0.27	0.21	enet	30	0.29	7.0e-09	-9.2	8.8	1.5e-18	-0.69	0.57	0.40	FALSE
27	GTEx	Colon Transverse	PKN2	0.23	0.08	lasso	7	0.08	1.0e-04	5.9	8.6	9.3e-18	-0.67	0.32	0.60	FALSE
58	The Cancer Genome Atlas	Colon Adenocarcinoma	CCBL2	0.23	0.28	lasso	3	0.26	3.9e-15	-9.2	8.6	1.1e-17	-0.69	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	CCBL2	0.09	0.12	enet	10	0.11	8.7e-13	-9.2	8.6	1.2e-17	-0.68	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CCBL2	0.14	0.09	enet	12	0.10	1.5e-08	-9.1	8.4	4.8e-17	-0.66	1.00	0.00	FALSE
42	GTEx	Small Intestine Terminal Ileum	PKN2	0.26	0.34	lasso	5	0.23	7.0e-06	-8.3	8.3	1.4e-16	-0.64	0.53	0.16	FALSE
17	GTEx	Brain Hypothalamus	CCBL2	0.34	0.00	enet	34	0.13	6.4e-04	-9.3	8.2	2.0e-16	-0.49	0.23	0.21	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CCBL2	0.10	0.07	enet	12	0.08	2.0e-09	-9.2	7.9	3.8e-15	-0.58	0.97	0.02	FALSE
57	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCBL2	0.09	0.08	blup	61	0.07	3.6e-04	-9.2	7.8	6.4e-15	-0.66	0.29	0.59	FALSE
79	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CCBL2	0.20	0.22	enet	16	0.18	8.6e-06	-9.2	7.8	9.0e-15	-0.65	0.26	0.67	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	CCBL2	0.25	0.00	enet	27	0.08	4.2e-05	-4.5	7.5	4.2e-14	-0.36	0.38	0.11	FALSE
52	YFS	Blood	CCBL2	0.10	0.05	bslmm	366	0.08	2.8e-26	-9.2	7.5	4.6e-14	-0.45	1.00	0.00	FALSE
67	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CCBL2	0.14	0.13	enet	15	0.12	9.7e-09	-9.1	7.3	2.4e-13	-0.63	1.00	0.00	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	CCBL2	0.27	0.20	enet	33	0.18	4.4e-07	-9.1	7.0	2.6e-12	-0.58	0.76	0.06	FALSE
10	GTEx	Artery Tibial	RBMXL1	0.06	0.06	enet	16	0.05	1.1e-04	4.6	6.5	8.7e-11	-0.23	0.80	0.02	FALSE
75	The Cancer Genome Atlas	Skin Cutaneous Melanoma	GBP3	0.35	0.13	blup	43	0.12	4.2e-04	-4.6	6.5	9.8e-11	-0.26	0.06	0.26	FALSE
47	GTEx	Vagina	GBP3	0.42	0.49	enet	18	0.49	6.5e-13	-4.6	6.4	1.9e-10	-0.23	0.92	0.05	FALSE
77	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CCBL2	0.17	0.13	blup	61	0.16	2.4e-06	-9.2	6.3	2.6e-10	-0.59	0.09	0.70	FALSE
37	GTEx	Pancreas	GBP3	0.39	0.26	enet	32	0.28	2.4e-12	-4.6	6.0	2.6e-09	-0.25	1.00	0.00	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	RBMXL1	0.05	0.05	lasso	3	0.04	4.4e-06	-5.3	5.9	3.2e-09	-0.17	0.97	0.00	FALSE
20	GTEx	Breast Mammary Tissue	GBP3	0.58	0.40	enet	20	0.44	6.3e-25	-4.5	5.4	5.4e-08	-0.17	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GBP3	0.50	0.47	lasso	3	0.48	2.9e-36	-4.6	5.3	1.1e-07	-0.17	1.00	0.00	FALSE
34	GTEx	Muscle Skeletal	GBP3	0.35	0.22	enet	13	0.26	7.4e-25	-4.6	5.2	1.6e-07	-0.13	1.00	0.00	FALSE
23	GTEx	Breast Mammary Tissue (Female)	GBP3	0.24	0.21	lasso	3	0.26	3.3e-08	-4.5	5.1	2.8e-07	-0.13	0.83	0.01	FALSE