Hub : Genes

BAG3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1330 0.0480 1.8e-03 0.033 NA 0.007 NA 0.025 1.6e-03 NA 8.9e-02 NA 5.1e-03
2 GTEx Esophagus Gastroesophageal Junction 0.4390 0.0910 1.4e-05 0.325 NA 0.175 NA 0.324 1.9e-12 NA 6.5e-07 NA 2.1e-12
3 NTR Blood 0.0527 0.0145 4.5e-08 0.021 0.026 0.032 0.028 0.027 2.3e-07 6.2e-09 1.0e-10 1.7e-09 2.8e-09
4 ROSMAP Brain Pre-frontal Cortex 0.1000 0.0322 5.0e-04 0.060 0.012 0.033 0.034 0.044 3.5e-08 8.8e-03 3.7e-05 2.6e-05 1.9e-06
5 YFS Blood 0.0387 0.0133 4.5e-05 0.031 0.014 0.027 0.024 0.030 2.2e-10 1.1e-05 2.5e-09 1.8e-08 4.8e-10
6 TCGA Breast Invasive Carcinoma 0.0217 0.0096 4.6e-04 0.005 0.012 0.005 NA 0.003 2.7e-02 1.1e-03 3.1e-02 NA 6.0e-02
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0406 0.0183 4.9e-04 0.045 0.034 0.032 NA 0.032 7.8e-06 9.2e-05 1.3e-04 NA 1.5e-04
8 TCGA Lung Squamous Cell Carcinoma 0.0435 0.0245 5.6e-03 0.021 0.004 0.002 NA 0.008 1.5e-03 1.1e-01 1.7e-01 NA 3.9e-02
9 TCGA Prostate Adenocarcinoma 0.0390 0.0206 3.8e-03 0.027 0.028 0.024 NA 0.028 6.8e-04 5.7e-04 1.3e-03 NA 6.0e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.3 0.5 1.2 0.9 0.2 0.3 1.0 -1.1 0.3 0.9 0.7 0.1
Bipolar Disorder or Schizophrenia 0.7 1.7 4.6 1.6 0.3 -0.4 2.2 -1.3 -1.3 0.5 1.5 1.5
Depressed Affect (Nagel 2018) 0.8 1.7 6.4 -1.6 -2.5 0.3 -0.7 1.2 1.2 -0.0 -1.1 -1.2
Depression (Nagel 2018) 0.2 0.3 1.5 -0.4 -1.2 0.1 0.6 0.2 0.0 -0.5 -0.0 0.8
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.9 -1.2 -0.4 0.7 -1.4 1.1 -0.1 0.4 -0.7 -0.3
Neuroticism (Nagel 2018) 0.6 1.3 7.1 -0.9 -2.7 -0.2 -0.0 0.6 1.7 0.4 -0.7 -0.6
Schizophrenia (2018) 0.8 1.7 3.8 1.4 0.3 -0.8 1.9 -0.8 -1.8 -0.1 1.4 1.9
Schizophrenia vs Biploar Disorder 0.9 1.2 2.8 -1.5 0.1 -0.2 -1.3 1.7 -1.1 -1.1 -1.1 -0.3
Worry (Nagel 2018) 0.3 0.6 3.1 -0.6 -1.2 -0.5 0.5 -0.0 1.8 -0.1 -0.3 -0.1
Alzheimer’s Disease (in mother) 0.5 0.6 3.2 -0.1 -0.5 -1.1 0.2 -0.9 1.8 -0.1 0.3 -0.3
Alzheimer’s Disease (in father) 2.4 2.6 6.4 1.6 -0.1 -0.5 1.5 -1.7 -2.0 0.9 2.5 2.2
Alzheimer’s Disease (including proxy) 0.6 0.9 2.8 0.2 -0.8 -1.7 0.6 -1.2 1.4 -0.2 0.7 0.1
Crohns Disease (2017) 0.9 1.9 3.6 1.7 1.6 -0.9 1.7 -1.9 1.0 1.4 1.1 0.7
Irritable Bowel Disease (IBD) 1.7 4.0 8.7 2.2 1.4 -1.4 2.3 -3.0 1.7 2.0 2.0 1.6
Ulcerative Colitis (UC) 1.3 2.4 5.2 1.4 0.6 -0.5 1.6 -2.3 1.4 1.8 1.8 1.7
Major Depression (MDD) 0.7 0.8 5.0 -0.0 0.1 -2.2 0.4 -0.2 1.3 -0.3 -0.4 0.3
Reaction Time 0.4 0.7 1.8 -1.1 -0.3 0.4 -0.4 0.9 1.3 0.9 -0.8 -0.7
Verbal and Numeric Reasoning (VNR) 0.7 1.8 6.3 1.3 -0.8 0.6 0.9 -1.5 0.5 2.5 1.8 0.7
Breast Cancer 1.9 4.5 14.8 -2.9 -0.8 0.5 -2.0 1.5 3.8 -0.3 -2.1 -2.3
Ovarian Cancer 0.2 0.3 1.3 -0.3 0.3 0.2 -0.4 0.2 0.5 -1.2 -0.5 -0.7
Prostate Cancer 0.1 0.1 0.1 0.1 -0.2 0.4 0.4 -0.4 -0.1 0.3 0.3 0.2
Age at First Birth 0.5 0.7 1.2 1.1 -0.9 -0.7 1.1 -1.0 0.4 0.7 0.6 0.8
Bipolar Disorder (2011) 1.0 1.0 2.0 1.1 -0.8 0.6 1.3 -1.4 0.8 1.2 0.9 0.6
Body Mass Index (BMI) (2010) 0.4 0.6 2.0 -0.9 0.8 -0.0 -1.4 0.7 0.2 -0.1 -0.6 -0.9
Coronary Artery Disease (CAD) 0.0 0.0 0.1 -0.2 0.2 -0.3 0.3 -0.2 -0.0 0.0 0.1 0.0
Crohns Disease (2012) 0.1 0.2 1.1 0.0 -0.1 -0.5 -0.2 -0.3 1.0 0.5 -0.2 -0.5
Mean Putamen Volume 1.1 1.2 4.5 -1.1 -0.0 1.0 -1.4 1.3 -2.1 -0.5 -0.7 0.3
Fasting Glucose 0.4 0.4 1.6 -0.5 0.3 1.3 0.0 0.3 -0.6 1.0 0.3 -0.5
HbA1C 2.8 3.1 10.4 -1.4 -0.8 -2.2 -0.5 0.3 3.2 -0.3 -1.2 -2.8
HDL Cholesterol 0.7 1.2 2.1 1.3 -1.3 -0.9 1.2 -1.4 0.5 0.9 1.1 0.9
LDL Cholesterol 0.4 0.6 2.6 0.1 -0.5 0.6 0.4 -0.3 1.0 1.6 0.8 0.1
Lupus 0.7 1.0 4.7 0.6 -0.2 -2.2 0.7 -0.9 -0.5 -0.5 0.6 1.3
Neuroticism (2016) 0.3 0.5 2.4 0.7 -1.5 0.3 0.4 -0.1 0.5 1.0 0.3 0.3
Primary Biliary Cirrhosis 1.0 1.4 2.9 -1.3 1.1 -0.6 -1.1 1.0 1.1 -0.8 -1.6 -1.7
Rheumatoid Arthritis 0.5 0.7 1.4 -0.8 -1.2 1.0 -1.1 0.9 -0.6 0.2 -0.3 -0.9
Schizophrenia (2014) 0.2 0.5 1.0 0.5 0.4 -0.9 1.0 -0.4 -1.0 -0.4 0.6 0.9
Triglycerides 0.2 0.3 0.8 -0.3 0.9 0.9 -0.3 0.4 -0.6 -0.1 0.1 0.3
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.4 0.3 1.3 1.5 0.2 -0.2 -1.3 1.3 0.8 -0.3
Ulcerative Colitis 1.1 1.6 4.1 0.6 1.5 -1.1 0.9 -2.0 1.7 0.4 1.0 1.0
Blood Eosinophil Count 0.2 1.3 6.2 0.3 1.1 -0.8 0.3 -0.7 1.5 -2.5 -0.0 -0.9
Blood Platelet Count 0.0 0.6 2.1 -0.5 1.4 1.1 -0.2 0.5 -0.8 0.6 -0.3 -0.0
Blood Red Count 0.1 1.3 2.9 1.2 0.7 0.5 1.7 -1.6 -0.4 0.6 1.6 1.1
Blood White Count 0.2 1.3 3.3 -0.8 -0.6 -0.1 -1.2 1.6 -0.0 -0.3 -1.8 -1.8
Heel T-Score 0.3 2.6 5.0 2.0 0.3 -1.4 2.2 -1.9 -1.3 1.2 1.8 1.6
BMI 0.4 2.0 7.8 -0.5 1.9 1.7 -0.8 1.5 -2.8 0.2 -0.3 1.0
Height 1.2 22.7 48.9 5.8 7.0 3.1 4.5 -6.4 -1.9 0.6 5.3 4.4
Waist Hip Ratio (WHR) 0.5 2.1 7.2 1.1 0.6 -1.8 1.2 -2.0 2.7 0.3 0.7 0.6
Systolic Blood Pressure 0.3 1.6 6.2 0.8 -0.1 0.4 1.4 -1.2 -2.5 -0.4 1.3 1.4
Smoking Status 0.9 2.2 11.2 -0.4 -3.4 -1.4 -0.5 0.6 1.6 -0.9 -1.3 -1.0
Allergy or Eczema 0.4 1.2 5.5 0.4 0.4 2.3 0.6 -0.9 0.6 1.3 0.9 -0.8
Cardiovascular Disease 1.9 6.4 11.3 2.8 -0.5 -0.0 3.4 -3.1 -1.8 2.2 3.1 3.3
Hypothyroidism (self reported) 0.8 1.9 4.1 1.5 1.1 -0.2 1.7 -1.6 -0.7 1.2 1.7 2.0
Respiratory disease 0.7 1.5 4.7 -1.1 0.2 0.3 -1.2 1.3 1.2 -0.9 -1.4 -2.2
Type 2 Diabetes (T2D) (2018) 1.3 2.4 6.4 1.1 0.4 1.0 1.7 -0.6 -2.3 1.4 1.4 2.5
Lung FEV1/FVC ratio 1.6 8.2 17.3 3.2 -1.1 1.9 2.8 -3.1 -3.2 0.9 4.2 3.6
Lung FVC 0.2 0.9 2.9 0.7 -1.7 -0.3 0.6 -0.3 -1.5 -0.5 0.7 1.1
Neuroticism 0.2 0.5 1.8 -0.6 -1.3 -0.6 0.5 0.1 1.1 -0.4 -0.2 -0.5
Chronotype (morning person) 0.9 2.1 3.8 2.0 -0.5 0.8 1.6 -1.5 -1.6 0.9 1.9 1.5
Hair Pigment 0.0 1.0 1.6 1.1 -0.9 -0.7 1.2 -1.2 0.2 1.3 1.1 0.5
Tanning 0.0 0.4 2.0 -0.4 -1.4 -0.6 -0.0 0.7 -0.4 -0.3 -0.7 0.4
Hand grip strength (left) 1.4 3.6 13.1 -1.2 3.6 1.4 -1.6 2.0 -2.9 0.2 -0.7 0.3
Number of treatments/medications taken 0.2 0.3 1.0 -0.2 -0.8 -0.1 0.9 -0.7 1.0 0.4 0.1 0.0
Average weekly spirits intake 0.9 1.2 1.7 1.3 -1.1 -1.0 1.2 -1.3 1.2 0.7 1.1 0.8
Sensitivity / hurt feelings 2.9 4.9 9.4 -2.6 -1.6 -0.4 -2.2 2.2 2.1 -1.5 -3.1 -2.9
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.1 -1.3 -1.5 0.9 -0.6 1.1 0.2 -0.0 -0.7 -0.0
Hearing difficulty/problems: Yes 0.2 0.3 1.2 -0.3 -1.1 0.3 0.6 -0.3 0.3 -0.7 0.1 0.1
Relative age of first facial hair 0.8 1.6 2.7 1.3 -1.6 -1.0 1.5 -1.3 0.6 1.4 1.1 1.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.2 0.7 1.0 0.0 1.4 -1.1 1.5 0.4 0.5 -0.4
Ever used hormone-replacement therapy (HRT) 1.4 1.8 6.4 -0.9 -2.5 -0.1 -0.8 0.5 2.1 -0.2 -1.2 -1.5
Ever had hysterectomy (womb removed) 0.7 0.8 1.7 0.8 1.3 -0.5 0.9 -1.0 -0.8 0.1 0.9 1.3
Systolic blood pressure, automated reading 0.3 0.8 4.2 0.2 0.9 0.1 1.0 -0.3 -2.0 0.1 0.6 1.0
Eye problems/disorders: Diabetes related eye disease 3.0 3.3 6.2 1.8 -1.2 0.4 2.4 -2.1 -0.3 2.2 2.5 1.8
Angina 1.1 1.4 3.7 1.0 0.8 -1.3 1.6 -1.9 1.4 -0.2 1.0 0.4
Medication for hormone replacement therapy 0.4 0.5 1.3 -0.1 -0.8 0.8 0.6 -0.4 1.2 0.7 0.1 -0.9
Vitamin and mineral supplements 0.7 1.0 5.2 0.4 0.6 -2.3 0.7 -1.0 -0.0 -1.3 0.1 -0.0
Supplements: Zinc 0.2 0.3 1.2 -0.2 1.1 0.4 -0.0 0.3 -0.3 0.8 0.2 0.2
Medication: Co-codamol 1.6 1.9 3.8 -1.7 -1.9 1.3 -1.1 1.2 1.0 -0.2 -1.3 -1.8
Medication: Metformin 1.2 1.7 3.6 1.2 -1.0 1.0 1.9 -0.8 -1.2 1.4 1.3 1.6
Diabetes (father) 2.2 2.7 5.1 2.2 1.5 0.8 2.0 -1.8 -0.9 2.0 1.9 0.8
Diabetes (mother) 2.2 2.8 5.4 1.9 -0.7 0.6 2.3 -2.3 -1.2 0.8 2.1 1.8
Severe depression (siblings) 0.9 1.0 4.6 0.1 -1.2 -2.2 0.9 -0.7 0.9 -0.7 0.2 0.6
Pack years adult smoking proportion 0.2 0.3 0.8 0.2 -0.3 -0.6 0.7 -0.5 0.9 0.4 0.3 0.2
Impedance of leg (right) 0.8 3.6 19.2 -0.9 -1.8 -1.8 -0.5 0.2 4.4 0.7 -1.1 -2.1
Leg fat-free mass (left) 1.4 7.6 21.6 2.0 4.7 2.4 1.4 -1.6 -4.2 -0.0 2.4 3.0
Trunk fat percentage 0.4 1.5 3.1 1.1 1.0 1.8 0.9 -1.1 -1.2 1.1 1.5 1.2
Hand grip strength (right) 1.1 3.0 15.4 -0.6 3.9 1.2 -0.9 1.4 -2.5 0.3 -0.4 0.6
Townsend deprivation index at recruitment 0.9 1.2 3.2 1.3 -0.1 -0.2 1.6 -1.8 0.1 0.7 1.6 0.5
Current tobacco smoking 1.3 2.1 8.8 -0.8 -3.0 -1.1 -0.6 1.1 1.5 -0.1 -1.3 -1.6
Average weekly fortified wine intake 0.3 0.3 1.0 -0.2 -0.4 0.0 -0.8 0.7 -0.5 -1.0 -0.6 0.4
Maternal smoking around birth 0.5 0.8 3.6 0.3 -0.1 -1.9 -0.1 -0.3 -0.3 -1.7 -0.3 -0.1
Fed-up feelings 0.3 0.6 2.5 -1.1 -1.6 0.3 -0.4 1.1 -0.5 -0.2 -0.5 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 3.5 0.6 -1.5 0.6 1.1 -0.6 -0.5 0.4 1.1 1.9
Relative age voice broke 0.7 1.1 2.7 1.3 -1.7 -0.1 1.2 -1.0 0.5 1.0 0.9 1.0
Taking other prescription medications 0.2 0.3 2.0 -0.1 0.1 -0.3 0.5 -0.3 1.4 0.4 -0.4 -0.1
Age when periods started (menarche) 2.2 5.3 13.3 2.7 -3.6 -0.4 2.8 -2.2 -0.1 1.6 2.3 2.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 1.3 -0.0 -0.4 -0.5 0.3 -0.4 -0.3 -0.3 -0.0 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 5.9 0.4 2.4 -0.1 0.4 -0.2 -0.7 -0.8 0.2 0.2
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 5.1 -0.8 -0.9 1.1 -0.4 0.8 0.0 2.3 -0.4 -0.0
Qualifications: CSEs or equivalent 1.0 1.3 2.8 -1.6 0.1 -0.6 -1.2 1.4 -0.1 -1.7 -1.4 -0.8
Serious illness, injury or assault to yourself 0.5 0.6 1.9 0.8 -1.4 -0.5 1.1 -1.0 0.2 0.3 0.8 0.5
High blood pressure 2.1 5.7 14.0 2.5 -0.6 0.6 2.6 -2.3 -3.2 1.2 2.7 3.7
Hayfever, allergic rhinitis or eczema 0.8 1.7 6.0 1.1 -0.3 2.5 1.2 -1.2 0.1 1.7 1.4 0.3
Multivitamins +/- minerals 0.5 0.7 3.9 0.2 -0.4 2.0 -0.0 0.3 -0.5 1.1 0.4 0.3
Stomach or abdominal pain in last month 0.6 0.8 3.7 -0.3 -1.9 -0.7 0.3 0.1 0.2 -1.3 -0.2 0.9
Supplements: Glucosamine 3.4 4.4 9.9 -2.9 -1.2 1.4 -2.7 3.1 -0.3 -0.7 -2.6 -1.9
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 5.3 -1.6 2.3 -0.8 -1.1 1.3 0.7 -0.0 -1.4 -0.7
Medication: Atenolol 1.6 2.0 5.9 1.2 -0.1 -1.7 1.6 -2.4 1.3 -0.9 1.0 1.4
Medication: Levothyroxine sodium 0.4 0.7 1.7 0.7 1.3 -0.9 0.9 -1.0 0.3 -0.2 0.5 0.9
Sitting height 1.1 8.0 24.0 3.0 4.9 0.8 2.6 -2.7 -2.5 0.1 2.8 3.1
Chronic bronchitis/emphysema (father) 0.3 0.3 2.4 -0.1 -1.5 -0.0 -0.0 -0.2 0.3 -0.4 -0.1 -0.3
High blood pressure (mother) 0.2 0.2 0.9 -0.3 -0.9 0.1 -0.3 0.7 -0.1 0.3 -0.5 0.3
Body mass index (BMI) 0.3 1.4 6.3 -0.3 1.2 1.8 -0.4 0.8 -2.5 0.5 0.2 0.9
Impedance of leg (left) 1.0 4.8 20.7 -1.3 -2.5 -1.8 -0.8 0.7 4.6 0.6 -1.6 -2.6
Leg predicted mass (left) 1.4 7.2 21.8 1.9 4.7 2.4 1.3 -1.4 -4.1 -0.2 2.2 2.9
Trunk fat mass 0.6 2.5 5.2 1.2 2.3 2.0 1.0 -1.1 -1.9 0.9 1.6 1.6
Waist circumference 0.4 1.6 7.7 0.8 2.8 0.8 0.7 -0.8 -1.0 0.4 0.9 1.4
Number of incorrect matches in round 1.2 2.1 3.5 -1.9 -1.5 -0.1 -1.6 1.5 1.1 -1.8 -1.7 -0.7
Past tobacco smoking 0.8 1.6 5.8 -0.8 1.7 2.4 -0.9 1.1 -1.1 1.1 -0.3 -0.2
Alcohol usually taken with meals 0.8 1.3 6.6 -0.3 0.0 2.6 -0.9 0.7 -1.5 1.0 0.2 0.7
Nervous feelings 0.4 0.8 2.4 0.6 0.1 -0.5 1.3 -0.8 1.5 0.9 0.6 0.9
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 7.3 -1.7 -2.7 2.1 -1.1 1.9 -0.1 1.6 -0.9 -0.4
Hearing difficulty/problems with background noise 0.6 1.0 3.1 -1.5 -0.3 0.0 -0.9 1.0 0.3 -1.8 -1.1 -0.7
Hair/balding pattern: Pattern 2 1.2 1.5 6.3 0.5 1.1 -2.5 0.8 -1.4 1.5 -1.0 0.3 -0.2
Had menopause 0.2 0.2 0.9 0.6 -0.9 -0.2 0.3 -0.2 0.8 -0.4 0.0 -0.1
Had other major operations 2.5 3.0 7.6 2.8 0.8 0.6 1.8 -2.0 -1.1 1.3 2.3 1.9
Forced vital capacity (FVC) 0.4 1.5 4.8 1.0 1.6 0.6 0.4 -0.5 -2.2 -0.9 0.7 1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.0 5.7 0.8 2.4 -0.0 0.7 -0.5 -1.2 -0.2 0.5 0.6
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.7 -0.3 -0.9 -0.2 -0.4 0.5 0.6 -0.4 -0.7 -0.8
Qualifications: None of the above 0.8 1.8 6.2 -0.3 -1.0 -2.2 0.1 -0.6 2.5 -1.4 -0.7 -1.1
Financial difficulties in last 2 years 0.9 1.3 7.8 -0.6 -2.8 0.8 -0.4 1.1 -0.1 0.3 -0.7 -0.8
Mouth/teeth dental problems 0.6 1.0 4.8 -0.1 -0.1 -1.4 -0.8 -0.3 2.2 -0.7 -0.1 -0.8
Heart attack 3.3 4.2 8.2 2.5 -0.2 -0.3 2.7 -2.9 0.6 1.9 2.7 2.2
Allergy 0.6 1.3 2.2 -1.2 0.5 -1.3 -1.5 1.5 -0.3 -1.1 -1.5 -0.5
Pain all over the body in last month 0.3 0.3 1.1 0.1 -0.0 1.0 -0.0 0.5 -0.9 0.4 -0.2 0.4
Diabetes (self-reported) 0.3 0.5 1.9 0.6 -0.7 0.1 1.4 -0.2 -0.9 0.4 0.4 0.8
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.2 0.7 1.1 0.1 1.1 -1.1 0.4 0.7 1.0 0.6
Medication: Ramipril 2.0 2.5 3.8 1.9 1.1 0.9 1.9 -1.5 -1.5 1.9 1.7 1.4
Medication: Simvastatin 0.4 0.6 3.3 0.6 -0.4 -0.1 0.4 -0.4 -0.6 0.4 0.7 1.8
Fluid intelligence score 1.9 4.0 11.5 2.1 -1.5 0.4 1.9 -2.2 0.6 3.4 2.4 1.7
Illnesses of siblings 0.8 1.1 2.9 -1.0 0.6 0.3 -1.3 1.6 0.4 0.2 -1.1 -1.7
Neuroticism score 0.7 1.5 3.1 -1.7 -1.3 -1.1 -0.5 0.8 1.8 -1.1 -1.2 -0.9
Weight 0.9 4.6 14.6 1.4 3.8 2.1 1.1 -1.1 -3.1 0.5 1.8 2.4
Impedance of arm (right) 1.1 5.2 12.2 3.2 -0.4 0.1 2.9 -3.5 1.2 1.8 3.0 1.6
Arm fat percentage (right) 0.5 1.9 4.8 0.9 0.9 2.1 0.7 -0.5 -2.2 1.1 1.3 1.5
Trunk fat-free mass 0.7 4.2 23.6 0.5 4.9 1.7 -0.0 -0.3 -2.8 -1.0 0.6 1.5
Hip circumference 0.7 2.9 7.9 1.0 2.5 2.0 0.6 -0.4 -2.8 0.6 1.3 2.1
Time employed in main current job 1.1 1.3 8.7 0.4 2.9 -1.3 0.3 0.1 0.6 0.1 -0.5 -0.1
Alcohol intake versus 10 years previously 0.5 0.8 1.9 0.7 0.5 -1.4 0.9 -1.4 1.0 -0.5 0.7 0.2
Father’s age at death 1.1 1.5 4.4 -1.1 -1.4 0.7 -1.6 1.2 0.8 2.1 -0.7 -0.6
Worrier / anxious feelings 0.1 0.1 0.3 -0.5 0.1 -0.4 0.0 0.2 0.2 -0.6 -0.4 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.8 -0.3 -0.5 -0.9 0.4 0.3 0.1 -0.4 -0.2 0.2
Falls in the last year 0.5 0.7 3.6 -0.4 -1.9 -0.2 -0.1 -0.1 1.1 -1.1 -0.2 -0.4
Hair/balding pattern: Pattern 3 0.7 1.1 3.4 0.7 0.7 1.6 0.1 -0.0 -1.9 1.5 0.7 0.4
Number of live births 0.1 0.1 0.6 0.5 -0.4 0.2 -0.1 0.2 -0.1 0.0 -0.4 -0.8
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 9.1 1.3 1.6 1.6 0.8 -0.6 -3.0 -0.5 1.3 2.3
Pulse rate 2.2 3.7 6.4 2.1 1.1 1.3 2.2 -1.9 -1.8 1.7 2.2 2.5
Happiness 0.5 0.6 4.9 0.3 -2.2 -0.4 0.4 -0.2 -0.2 0.2 0.2 -0.1
Noisy workplace 0.9 1.1 7.0 -0.2 -2.6 1.2 -0.5 0.7 -0.5 -0.3 -0.3 -0.2
Qualifications: A levels/AS levels or equivalent 0.9 1.9 4.1 1.2 -0.1 1.5 0.7 -0.9 -1.8 1.8 2.0 1.3
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 3.5 -1.7 0.7 -1.9 -1.2 1.1 0.1 -1.4 -1.4 -1.0
Mouth/teeth dental problems: Dentures 0.4 0.6 1.7 -1.0 -1.3 -0.1 -0.5 0.5 -0.1 -1.1 -0.9 -0.5
Asthma 0.2 0.4 2.0 -0.5 0.2 0.6 -0.5 0.6 0.6 -0.1 -0.6 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.5 -0.3 -0.7 0.6 0.1 0.3 -0.7 0.5 0.0 0.2
Medication: Cholesterol lowering 1.8 2.9 4.9 2.2 -0.8 0.4 2.0 -1.3 -1.7 2.2 1.8 1.9
Depression (self-reported) 0.3 0.4 1.5 -0.5 -0.8 -0.3 -0.7 0.4 -0.2 -1.2 -0.5 0.3
Medication: Lansoprazole 2.2 2.5 5.0 -2.0 0.4 -1.5 -1.6 1.6 0.9 -2.2 -2.0 -1.1
Prospective memory result 0.6 0.8 3.1 -0.7 -1.7 1.1 -0.7 0.8 0.2 0.5 -0.5 -0.8
Lung cancer (father) 1.3 1.5 4.2 -1.1 0.8 0.0 -1.7 2.1 -1.0 -1.1 -1.6 -0.3
Illnesses of mother 0.3 0.3 1.4 0.2 0.1 -0.9 -0.3 0.3 -0.5 -1.2 -0.6 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.8 7.9 2.1 1.5 1.3 1.7 -1.7 -2.8 -0.3 2.2 2.8
Pulse wave Arterial Stiffness index 0.7 0.8 1.8 -1.2 -0.1 0.7 -0.8 1.1 0.6 0.3 -1.3 -1.1
Impedance of arm (left) 1.0 4.6 10.8 3.0 -0.6 0.4 2.8 -3.3 1.0 1.8 2.8 1.2
Arm fat mass (right) 0.7 2.7 7.2 1.0 1.9 2.2 0.8 -0.6 -2.7 0.9 1.4 1.8
Trunk predicted mass 0.8 4.3 23.8 0.4 4.9 1.7 -0.1 -0.2 -2.9 -0.9 0.6 1.5
Standing height 1.1 11.0 35.9 3.6 6.0 1.3 2.9 -3.8 -1.6 0.2 3.5 3.3
Length of working week for main job 0.5 0.5 3.1 -0.2 1.8 -0.8 0.3 -0.5 0.5 -0.5 -0.0 -0.1
Exposure to tobacco smoke at home 0.5 0.5 2.0 0.1 -0.2 -1.4 0.6 -0.7 1.3 -0.3 0.0 -0.0
Breastfed as a baby 1.0 1.3 2.7 -1.4 -0.2 0.3 -1.5 1.5 -0.1 -1.5 -1.6 -0.6
Tense / ‘highly strung’ 0.3 0.5 1.9 -0.8 -0.3 -0.4 -0.5 0.7 1.4 0.2 -0.8 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 4.5 -1.3 -1.2 -1.3 -0.9 0.7 2.1 -1.0 -1.5 -0.6
Hair/balding pattern: Pattern 4 0.2 0.5 2.5 0.1 -0.6 0.9 0.5 0.7 -0.3 1.6 0.0 -0.1
Birth weight of first child 0.4 0.7 2.5 -0.2 1.5 0.9 0.1 0.7 -1.6 -0.0 -0.1 0.6
Peak expiratory flow (PEF) 0.2 0.5 1.7 0.3 1.3 0.9 0.0 -0.0 -1.1 -0.3 0.4 0.7
Pulse wave reflection index 1.6 2.0 4.2 -1.6 -0.8 0.7 -1.7 2.0 0.4 0.4 -1.6 -2.0
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.8 0.5 -0.0 0.2 0.6 -0.1 -0.2 1.3 0.6 0.4
Loud music exposure frequency 1.3 1.4 3.5 1.1 0.3 -0.1 1.8 -1.5 -0.2 -0.2 1.5 1.9
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.0 -0.4 0.8 0.4 -0.7 1.0 -0.6 0.3 -0.3 0.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.6 0.3 0.5 0.8 1.1 -0.3 -1.3 0.5 0.2 1.2
Blood clot in the leg (DVT) 0.8 1.0 2.0 1.3 -1.3 -1.1 1.1 -1.4 -0.1 0.1 1.1 0.4
Medication: Paracetamol 0.7 1.2 6.2 -0.2 0.0 -1.5 0.7 -0.5 2.5 -1.1 -0.3 -0.6
Headache pain in last month 0.4 0.8 2.2 0.5 -0.3 0.6 1.1 -0.1 -1.3 0.7 0.7 1.5
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 5.4 -2.3 0.6 0.4 -2.3 1.7 1.5 -2.0 -2.0 -2.3
Glaucoma (self-reported) 1.2 1.4 2.7 1.4 -1.4 0.4 1.2 -1.1 -1.0 0.6 1.2 1.6
Gout (self-reported) 0.8 1.1 3.3 -0.8 1.0 0.0 -0.7 0.4 1.8 0.2 -1.1 -1.8
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.7 1.5 0.6 -0.7 1.7 -1.9 0.7 1.5 1.6 1.3
Medication: Amlodipine 1.6 2.2 6.0 1.2 -2.4 -0.8 2.0 -1.6 -0.6 -0.1 1.4 1.8
Medication: Ventolin 100micrograms inhaler 0.9 1.2 4.4 0.0 -0.0 -1.7 0.6 -0.8 2.1 -1.3 -0.3 -0.8
Birth weight 0.8 1.8 5.7 -1.5 2.4 0.7 -1.7 0.9 1.4 -0.6 -1.0 -0.8
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.2 -0.1 -0.9 1.1 -0.7 0.7 -0.6 0.0 -0.5 -0.4
High blood pressure (siblings) 0.5 0.7 1.7 0.9 -0.4 -0.7 0.8 -1.3 -0.5 -0.6 0.6 1.3
Forced vital capacity (FVC), Best measure 0.7 2.7 5.3 1.8 2.0 0.7 1.4 -1.5 -1.9 -0.2 1.7 2.3
Body fat percentage 0.2 1.0 3.4 0.5 0.5 1.8 0.4 -0.4 -1.2 1.1 1.0 0.9
Leg fat percentage (right) 0.1 0.2 0.5 -0.7 -0.2 0.5 -0.6 0.6 0.0 0.4 -0.3 -0.1
Arm fat-free mass (right) 0.5 2.6 13.5 0.1 3.7 1.1 -0.2 0.1 -2.4 -1.1 0.2 1.1
Exposure to tobacco smoke outside home 0.4 0.5 0.9 0.5 -0.3 0.3 1.0 -0.5 -0.9 0.2 1.0 0.9
Comparative body size at age 10 0.5 1.5 4.6 0.2 -0.8 2.1 -0.3 0.0 -1.6 2.1 1.1 0.4
Number of full brothers 0.5 0.6 2.0 -0.4 1.4 -1.4 0.5 -0.2 0.6 -0.4 -0.5 -0.3
Worry too long after embarrassment 0.3 0.6 1.9 0.5 -0.5 0.7 0.9 -0.3 -1.0 0.3 0.6 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.5 -1.1 -0.4 0.1 -0.6 0.3 1.6 -1.1 -1.0 -0.8
Wheeze or whistling in the chest in last year 0.5 0.9 3.1 -0.6 -1.8 -0.9 0.2 0.5 1.4 -0.3 -0.8 -0.7
Number of children fathered 1.9 2.1 3.8 -2.0 0.4 0.2 -1.9 1.9 0.5 -1.5 -1.9 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 3.8 -0.9 -1.3 0.4 -0.9 1.3 -1.9 -0.0 -0.2 0.3
Age at first live birth 1.1 1.9 2.9 1.7 1.3 -1.6 1.5 -1.3 -1.2 -0.5 1.3 1.7
Pulse wave peak to peak time 1.0 1.2 2.3 1.4 0.5 -0.8 1.1 -1.4 -0.5 -0.3 1.5 1.3
Health satisfaction 1.0 1.3 3.9 1.4 -2.0 -0.8 1.4 -1.3 0.1 -0.3 0.9 0.8
Shortness of breath walking on level ground 0.2 0.2 1.6 0.6 0.0 -0.0 -0.0 -0.0 -0.0 -0.5 -0.2 -1.2
Qualifications: College or University degree 1.2 3.9 9.9 1.8 1.4 2.1 1.1 -1.0 -3.1 1.9 2.3 2.0
Eye problems/disorders: None of the above 1.0 1.1 3.5 -0.7 1.8 0.4 -1.0 0.8 0.7 0.0 -0.7 -1.9
Mouth/teeth dental problems: Loose teeth 1.1 1.3 3.7 0.9 1.5 -0.6 1.9 -1.4 -0.4 1.0 1.0 1.0
Emphysema/chronic bronchitis 0.1 0.1 0.4 -0.4 0.6 0.3 0.1 -0.2 0.4 0.2 0.1 -0.4
Medication for pain relief, constipation, heartburn 0.5 0.9 2.7 -0.7 0.3 1.0 -1.6 1.1 -0.7 -0.1 -0.8 -1.0
Neck or shoulder pain in last month 0.9 1.3 7.6 0.2 -2.8 1.0 0.5 0.6 -1.3 0.6 0.0 0.8
Medication: Blood pressure 2.3 4.0 8.6 2.6 -0.8 -0.6 2.3 -2.1 -1.6 1.5 2.3 2.9
Angina (self-reported) 1.2 1.6 3.7 1.1 1.3 -1.5 1.7 -1.9 1.3 -0.4 1.0 0.5
Migraine (self-reported) 0.1 0.2 0.7 0.0 -0.1 -0.8 0.7 -0.4 -0.1 -0.3 0.1 0.4
Medication: Ibuprofen 0.3 0.3 0.9 -0.8 -0.9 0.8 -0.2 0.5 -0.7 -0.0 -0.2 0.3
Medication: Allopurinol 0.6 0.8 2.8 -0.7 0.5 0.9 -0.8 0.5 0.8 0.2 -0.9 -1.7
Medication: Omeprazole 0.8 1.0 2.1 1.1 1.4 -0.3 1.2 -1.4 -0.0 0.1 1.1 0.7
Medication: Seretide 50 evohaler 0.2 0.2 0.8 -0.3 -0.3 -0.4 0.0 0.3 0.9 -0.2 -0.4 -0.8
Mean time to correctly identify matches 0.7 1.3 3.5 -1.6 -0.6 0.0 -0.8 1.0 1.9 -0.4 -1.4 -1.1
Heart disease (mother) 2.2 2.7 4.8 1.7 1.4 -0.4 2.2 -1.9 -0.2 2.1 1.8 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.0 -0.2 -1.0 1.0 -0.6 0.5 -0.7 0.9 -0.2 -0.5
Whole body fat mass 0.6 2.5 5.4 1.1 1.9 2.3 0.8 -0.9 -2.1 1.3 1.5 1.7
Leg fat mass (right) 0.2 0.9 2.3 0.1 1.4 1.5 0.1 0.0 -1.5 0.6 0.5 0.8
Arm predicted mass (right) 0.5 2.3 13.7 -0.1 3.7 0.9 -0.4 0.3 -2.1 -1.1 -0.0 0.8
Pulse rate, automated reading 1.4 4.5 7.1 2.6 2.0 0.3 2.7 -2.6 -2.1 0.2 2.1 2.5
Alcohol intake frequency. 0.3 0.6 1.3 0.5 1.0 0.4 0.9 -1.2 -0.3 -0.1 1.0 1.0
Comparative height size at age 10 0.6 3.4 26.4 0.9 5.1 0.6 0.5 -1.0 -0.4 -0.2 1.0 0.2
Number of full sisters 0.7 0.9 4.1 -1.0 0.0 -0.3 -0.5 0.5 2.0 0.1 -1.0 -1.0
Suffer from ‘nerves’ 0.1 0.1 0.4 -0.2 -0.6 -0.1 0.7 -0.1 0.4 0.2 0.0 0.6
Overall health rating 0.6 1.4 3.7 1.2 -1.9 -0.7 1.9 -1.2 1.3 -0.2 0.2 -0.2
Chest pain or discomfort 0.7 0.9 3.3 -0.1 -1.0 -0.5 0.6 -0.6 1.8 0.7 -0.3 -1.6
Had major operations 0.3 0.3 1.2 0.3 0.2 -1.1 0.6 -0.7 0.6 -0.0 0.4 0.2
Age at last live birth 1.3 1.8 3.9 1.5 0.4 -2.0 1.1 -1.0 -1.3 -1.5 0.8 1.8
Family relationship satisfaction 1.2 1.5 9.1 0.1 -3.0 1.6 -0.1 0.3 -0.0 0.9 0.4 -0.6
Leg pain on walking 0.5 0.6 0.9 0.9 -0.7 -0.5 0.9 -0.7 -0.9 0.5 0.9 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.7 -0.8 -0.5 0.6 -0.2 0.6 -0.6 -0.5 0.1 0.5
Commuting to job workplace: Car/motor vehicle 1.3 1.5 4.5 0.9 0.4 2.1 0.5 -1.1 -1.0 0.4 1.4 1.8
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 4.7 0.2 2.2 0.8 -0.4 0.0 -0.1 0.3 0.1 0.6
Medication: Aspirin 1.9 2.5 6.0 1.6 -2.5 -0.8 2.1 -1.5 -0.7 0.9 1.6 1.6
Supplements: Vitamin C 1.1 1.3 2.7 -1.3 -0.8 1.6 -1.2 1.6 0.7 0.6 -0.9 -1.0
Knee pain experienced in last month 0.3 0.5 1.5 -1.0 -0.5 0.5 -0.5 1.2 -0.6 -0.4 -0.6 -0.0
Hypertension (Self-reported) 1.7 4.8 10.6 2.2 -0.3 0.7 2.3 -2.1 -3.1 1.2 2.3 3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.8 3.6 -1.6 1.1 -0.6 -1.6 1.9 0.3 -1.0 -1.9 -1.3
Illnesses of father: Heart disease 0.9 1.2 2.3 0.9 0.9 1.5 0.7 -1.5 0.2 1.0 1.4 1.2
Illnesses of siblings: Diabetes 0.6 0.7 2.2 0.1 -0.6 -1.5 0.7 -0.7 0.5 -1.5 -0.1 0.8
Smoking status: Previous 0.8 1.3 3.4 1.0 -1.4 -1.8 1.1 -1.3 0.7 -0.8 0.6 0.7
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.5 9.5 3.1 1.1 1.2 2.6 -2.4 -1.8 2.0 2.9 3.0
Whole body fat-free mass 0.9 5.1 23.3 0.9 4.8 1.9 0.4 -0.6 -3.4 -0.7 1.2 2.0
Leg fat-free mass (right) 1.4 7.6 20.6 1.9 4.5 2.4 1.4 -1.4 -4.4 -0.1 2.3 3.1
Arm fat percentage (left) 0.4 1.7 4.9 0.8 0.6 2.1 0.6 -0.5 -2.2 0.9 1.2 1.2
Average weekly red wine intake 0.9 1.3 5.6 -0.8 0.3 1.4 -1.0 1.2 -2.4 0.8 -0.0 0.3
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.2 0.5 -0.1 -0.2 -0.3 0.3 -0.2 -0.2 -0.3
Mood swings 0.4 0.7 3.6 -0.8 -1.9 -0.0 -0.1 0.6 0.7 -0.3 -0.9 -0.2
Loneliness, isolation 1.0 1.4 7.2 -0.4 -0.1 -2.7 -0.0 0.2 1.8 -1.2 -0.8 -0.2
Long-standing illness, disability or infirmity 1.2 1.9 5.9 1.5 -1.1 -0.0 2.4 -1.7 0.5 1.0 1.2 1.4
Ever had bowel cancer screening 0.1 0.1 0.7 -0.1 -0.4 0.0 -0.1 -0.2 0.9 -0.2 -0.3 -0.3
Diabetes diagnosed by doctor 0.8 1.3 3.0 0.8 -0.1 0.8 1.7 -0.3 -1.7 0.8 0.9 1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 4.6 0.3 -2.1 1.2 -0.4 0.2 -0.0 0.3 0.1 -0.4
Friendships satisfaction 0.7 0.9 6.4 0.2 -2.5 -0.1 -0.1 -0.2 0.7 0.0 -0.1 -1.1
Qualifications: nursing, teaching 0.6 0.9 2.2 1.5 0.4 1.0 0.4 -1.0 -0.6 1.3 1.4 0.5
Commuting to job workplace: Walk 0.4 0.5 1.7 0.8 0.7 -1.3 1.0 -0.2 -0.1 0.1 0.0 0.5
Eye problems/disorders: Cataract 0.8 1.0 2.7 -0.5 -1.6 -1.0 -0.8 1.0 -0.7 -1.2 -0.8 0.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 3.4 0.2 0.1 0.8 0.0 0.5 -1.8 0.7 0.5 0.3
Medication for cholesterol 1.5 2.3 4.8 -1.2 1.6 -0.6 -1.9 1.6 1.5 -0.5 -1.8 -2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 4.0 0.5 2.0 -0.7 0.5 -0.7 0.1 -0.3 0.2 0.1
Back pain experienced in last month 0.8 1.1 4.6 0.9 -2.1 -0.4 1.7 -0.8 -0.4 0.6 0.6 0.4
Mineral and other dietary supplements 0.6 0.8 2.5 0.3 0.8 -1.4 0.3 -0.8 1.1 -1.6 0.1 -0.2
Breast cancer (self-reported) 1.0 1.2 2.9 1.7 -1.0 -0.6 1.3 -1.6 1.0 0.9 0.8 -0.2
Asthma (self-reported) 0.2 0.4 1.7 -0.2 0.0 0.7 -0.4 0.4 0.6 0.2 -0.5 -1.3
Osteoporosis (self-reported) 0.5 0.6 1.4 0.5 -0.4 -1.2 0.4 -1.1 1.2 0.4 0.8 0.1
Osteoarthritis (self-reported) 0.3 0.4 0.8 0.2 -0.9 0.4 -0.2 0.6 -0.9 0.7 -0.1 0.5
Medication: Aspirin 1.4 1.9 3.7 1.5 -1.7 -0.6 1.9 -1.3 -0.7 0.9 1.4 1.6
Medication: Gliclazide 0.2 0.2 0.7 -0.1 0.5 -0.0 0.3 0.1 -0.8 -0.3 0.2 0.6
Illnesses of father: None of the above (group 1) 1.5 1.8 3.6 -1.2 -1.1 -1.0 -1.4 1.7 0.1 -1.9 -1.6 -1.1
Smoking status: Current 0.9 1.5 6.6 -0.5 -2.6 -0.9 -0.4 0.7 1.4 0.0 -0.9 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 1.9 1.0 -1.0 0.6 1.0 -1.1 -1.4 -0.2 1.3 1.1
Whole body water mass 0.9 5.2 23.2 0.9 4.8 1.9 0.5 -0.6 -3.5 -0.8 1.2 2.2
Leg predicted mass (right) 1.4 7.5 20.9 1.9 4.6 2.5 1.4 -1.4 -4.3 -0.1 2.2 3.0
Arm fat mass (left) 0.6 2.5 7.0 0.8 1.9 2.4 0.7 -0.5 -2.6 0.8 1.3 1.7
Number of self-reported non-cancer illnesses 1.7 2.9 5.2 1.5 -1.1 1.9 2.1 -1.6 -0.2 2.3 1.7 1.9
Average weekly champagne plus white wine intake 0.1 0.2 0.9 0.0 0.9 -0.0 -0.2 0.1 0.0 -0.5 -0.2 -0.5
Miserableness 0.7 1.2 5.2 -1.1 -2.3 -0.3 -0.7 0.6 1.0 -0.1 -0.9 -1.4
Guilty feelings 0.6 0.9 2.0 -1.3 -1.4 -0.1 -0.9 1.2 0.7 -0.3 -0.8 -1.0
Wears glasses or contact lenses 0.8 0.9 2.5 1.0 -0.4 -1.6 0.6 -1.3 1.3 -0.4 0.5 -0.4
Ever taken oral contraceptive pill 0.4 0.5 1.8 0.1 -1.2 1.3 0.2 0.0 -0.5 0.5 0.3 0.8
Hearing aid user 0.7 0.8 3.4 -0.5 -0.4 1.8 0.2 0.1 -1.7 -0.2 0.5 0.3
Mother’s age at death 0.4 0.6 3.8 -0.2 -1.9 0.3 -0.4 0.5 -0.7 -0.1 0.1 0.3
Financial situation satisfaction 0.7 0.8 3.8 -0.1 0.1 1.4 -0.4 1.2 -2.0 -0.0 -0.3 0.2
Tinnitus: Yes, now most or all of the time 0.9 1.1 3.8 0.7 -0.5 1.9 0.5 0.1 -2.0 0.4 0.8 0.7
Commuting to job workplace: Public transport 0.4 0.4 1.2 -0.6 -1.1 -0.2 -0.3 0.9 -1.0 0.6 -0.5 0.0
Eye problems/disorders: Glaucoma 2.4 2.8 6.6 2.0 -1.0 0.4 2.2 -1.9 -0.8 0.7 2.1 2.6
Medication: Blood pressure 1.2 2.4 5.5 1.3 -1.2 -0.4 1.9 -1.8 -1.7 0.0 1.8 2.3
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.1 0.7 0.2 0.5 1.0 -0.3 -1.4 0.9 1.0 1.1
Supplements: Fish oil (including cod liver oil) 2.0 2.6 6.5 1.3 -1.3 1.7 0.9 -0.3 -2.3 2.5 1.3 1.8
High cholesterol (Self-reported) 0.3 0.6 1.4 0.4 0.6 0.6 0.8 -0.4 -0.5 1.1 0.8 1.2
Medication: Bendroflumethiazide 1.0 1.5 3.4 1.4 -1.2 -0.7 1.0 -1.1 -1.8 0.5 1.5 1.0
Medication: Paracetamol 0.5 0.8 3.6 -0.0 0.2 -1.2 0.9 -0.7 1.9 -1.1 -0.0 -0.3
Medication: Lisinopril 2.1 2.7 6.3 2.1 -1.6 -0.7 2.1 -2.5 0.6 0.6 1.5 1.8
Medication: Atorvastatin 3.0 3.7 7.0 2.4 -1.4 -0.1 2.6 -2.6 -0.0 1.6 2.4 1.8
Illnesses of father: High blood pressure 0.8 1.0 4.6 0.8 2.1 -0.4 0.5 -0.2 -0.6 1.5 0.3 0.3
Alcohol drinker status: Never 0.5 0.6 2.8 -0.3 -0.7 -0.1 -0.7 0.7 -1.7 -0.4 -0.2 1.0
Ever smoked 0.6 1.1 5.7 0.2 -2.4 -1.4 0.2 -0.1 1.0 -0.9 -0.4 -0.3
Basal metabolic rate 0.9 5.1 21.3 1.1 4.6 2.0 0.6 -0.8 -3.4 -0.4 1.4 2.2
Leg fat percentage (left) 0.1 0.4 0.9 -0.9 -0.6 0.6 -0.7 0.8 0.1 0.4 -0.5 -0.4
Arm fat-free mass (left) 0.6 3.2 17.6 0.4 4.2 1.2 0.1 -0.2 -2.5 -0.7 0.6 1.6
Number of operations (self-reported) 0.3 0.4 0.8 0.9 -0.9 0.6 0.4 -0.8 0.1 0.6 0.7 0.6
Average weekly beer plus cider intake 0.9 1.3 3.8 0.4 -2.0 -1.6 0.8 -0.3 1.8 -0.2 -0.8 -0.9
Irritability 0.2 0.4 2.5 -0.2 -1.6 -0.5 -0.4 0.6 -0.0 -0.2 -0.2 0.6
Risk taking 0.7 1.0 3.2 0.5 1.2 1.1 0.8 0.1 -1.4 0.1 0.8 1.8
Ever had prostate specific antigen (PSA) test 1.8 2.0 4.7 1.1 -0.3 2.0 0.6 -0.3 -2.2 1.5 1.4 1.9
Fractured/broken bones in last 5 years 1.0 1.3 4.9 1.2 -2.2 0.7 1.0 -1.3 0.7 1.0 1.2 -0.3
Age started oral contraceptive pill 1.7 2.2 6.2 0.8 -0.6 -2.5 0.9 -2.0 2.3 -1.2 0.4 -0.8
Diastolic blood pressure, automated reading 1.0 3.1 8.6 1.2 2.1 1.8 1.4 -1.0 -2.9 1.4 1.5 1.9
Ever depressed for a whole week 0.7 0.8 2.0 -1.0 -1.4 0.5 -1.0 1.0 -0.3 -1.1 -0.8 -0.6
Unable to work because of sickness or disability 0.7 1.0 4.0 1.0 0.2 0.5 1.2 -0.4 -2.0 0.1 0.8 1.0
Commuting to job workplace: Cycle 0.5 0.6 1.5 -1.2 -0.5 -0.1 -1.0 1.0 -1.0 -0.4 -0.3 -0.5
Myopia 0.3 0.4 1.3 0.3 -0.8 -0.7 0.6 -0.5 -0.1 -0.6 0.6 1.1
Vascular/heart problems diagnosed by doctor 2.5 6.9 16.2 -2.8 0.4 -0.3 -3.1 2.8 2.9 -1.3 -3.1 -4.0
Cholesterol lowering medication 0.2 0.4 1.5 -0.1 -0.3 -0.2 0.5 -0.7 0.2 -0.5 0.7 1.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 1.3 0.3 1.1 -0.5 0.4 -0.6 0.1 -0.1 0.5 0.3
Pain experienced in last month 0.6 1.0 2.1 1.2 1.4 -1.4 0.5 -1.4 0.7 0.0 0.9 0.2
Supplements: Calcium 2.7 2.9 5.7 1.7 0.8 0.8 1.9 -1.7 -0.7 2.1 2.4 2.3
Basal cell carcinoma (self-reported) 0.2 0.2 0.7 -0.6 0.2 -0.0 -0.8 0.6 0.2 -0.3 -0.4 -0.4
Heart attack/myocardial infarction (self-reported) 3.6 4.7 8.8 2.8 -0.1 -0.2 2.8 -3.0 0.3 1.9 2.9 2.4
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.3 1.0 -1.2 -1.1 0.8 -1.0 -0.1 -0.4 0.7 -0.1
Heart disease (siblings) 0.3 0.4 1.1 0.5 -0.4 0.4 0.8 -1.0 0.9 -0.1 0.4 -0.0
Alcohol drinker status: Previous 0.6 0.7 2.4 0.4 1.5 -0.1 1.3 -0.8 0.8 0.8 0.4 0.5
Pack years of smoking 0.1 0.2 1.1 -0.2 -0.5 -0.6 0.3 -0.3 1.1 -0.0 -0.1 -0.1
Impedance of whole body 0.6 2.9 7.2 1.7 -1.3 -0.7 1.8 -2.2 2.7 1.8 1.5 0.1
Leg fat mass (left) 0.2 0.8 2.5 -0.0 1.2 1.6 -0.1 0.2 -1.5 0.6 0.4 0.6
Arm predicted mass (left) 0.6 2.9 16.0 0.2 4.0 1.2 -0.1 -0.0 -2.4 -0.7 0.4 1.5