TWAS hub - GRK5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.1540	0.0450	2.6e-04	0.122	NA	0.081	NA	0.107	1.3e-09	NA	9.3e-07	NA	1.6e-08
2	GTEx	Whole Blood	0.1110	0.0430	4.5e-03	0.007	NA	-0.003	NA	0.014	6.3e-02	NA	9.2e-01	NA	1.8e-02
3	METSIM	Adipose	0.0603	0.0220	6.3e-04	0.001	0.019	0.022	0.02	0.004	1.8e-01	5.8e-04	2.2e-04	4.4e-04	7.3e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.1174	0.0311	1.4e-06	0.034	0.041	0.055	0.05	0.065	3.1e-05	4.8e-06	1.3e-07	4.8e-07	1.0e-08
5	TCGA	Thyroid Carcinoma	0.1580	0.0410	2.1e-09	0.165	0.132	0.157	NA	0.163	8.1e-16	7.6e-13	4.2e-15	NA	1.3e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Commuting to job workplace: Walk	5.5	6.0	14.3	3.8	-0.7	1.3	1.0	3.5
Age when periods started (menarche)	3.9	9.3	12.8	3.6	-2.4	2.4	3.2	3.4
Length of working week for main job	3.4	3.7	9.2	-1.9	1.1	-1.5	-3.0	-1.7
Supplements: Fish oil (including cod liver oil)	3.1	4.1	5.8	2.2	-2.4	-2.0	-1.1	2.1
Bipolar Disorder (2018)	2.7	4.2	8.7	-2.8	0.4	-2.0	0.1	-3.0
Commuting to job workplace: Car/motor vehicle	2.7	3.1	6.4	-2.1	-0.7	-2.5	-0.9	-1.9
Current tobacco smoking	2.6	4.2	19.1	0.9	4.4	-0.1	-0.3	1.0
Number of children fathered	2.6	2.9	5.6	-2.4	-1.9	-0.8	0.2	-2.2
Health satisfaction	2.6	3.4	16.1	0.1	4.0	0.9	0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.1	6.1	2.5	-0.3	-1.2	-1.3	2.4
Mineral and other dietary supplements	2.6	3.5	8.1	-1.1	2.2	2.8	1.7	-0.8
Smoking status: Current	2.6	4.2	19.4	0.8	4.4	0.2	-0.2	0.9
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	5.8	0.4	2.4	2.3	1.8	0.7
Medication: Lansoprazole	2.5	2.9	4.6	2.0	0.6	2.1	1.0	2.1
Allergy or Eczema	2.2	5.8	19.9	-0.8	0.8	-2.6	-4.5	-1.2
Ever had bowel cancer screening	2.2	2.6	6.5	2.5	-0.4	-0.3	0.6	2.5
Basal cell carcinoma (self-reported)	2.2	2.6	4.5	2.0	1.2	1.7	0.2	2.1
Average weekly spirits intake	2.1	2.6	4.8	1.2	-1.2	1.9	2.2	1.4
Hair/balding pattern: Pattern 3	2.1	3.1	6.9	-2.6	-1.4	0.3	0.9	-2.4
Pulse wave reflection index	2.1	2.6	3.5	1.8	1.9	1.2	1.6	1.6
Loud music exposure frequency	2.1	2.3	4.3	-2.1	-0.3	-1.0	1.5	-2.1
Risk taking	2.1	3.1	4.9	1.7	2.0	1.3	2.2	1.4
Mean Putamen Volume	2.0	2.3	4.8	-1.1	-2.1	-2.2	0.2	-1.1
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.9	-0.4	2.2	1.9	1.7	-0.0
Chest pain or discomfort	2.0	3.0	10.6	1.4	3.2	-0.6	-0.1	1.4
Ever depressed for a whole week	2.0	2.5	5.5	-0.6	1.1	2.3	2.3	-0.6
Headache pain in last month	1.9	3.3	6.1	2.1	2.1	0.5	1.2	2.5
Leg fat percentage (left)	1.9	6.8	23.3	-1.4	-0.5	2.8	4.8	-0.9
High blood pressure (mother)	1.8	2.6	5.3	1.2	1.1	1.7	2.3	1.4
Hayfever, allergic rhinitis or eczema	1.7	3.6	14.4	0.3	0.8	-1.7	-3.8	-0.1
Ever had prostate specific antigen (PSA) test	1.7	1.9	3.8	-1.2	0.2	-2.0	-1.8	-0.9
Bipolar Disorder (2011)	1.6	1.5	2.5	-1.4	-0.4	-1.6	1.0	-1.5
Lung FEV1/FVC ratio	1.6	8.0	30.2	0.6	-0.5	2.9	5.5	0.9
Hair/balding pattern: Pattern 4	1.6	3.8	7.8	2.8	2.0	-0.6	-1.3	2.3
Leg fat percentage (right)	1.6	5.6	19.5	-1.5	-0.3	2.3	4.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	5.9	-2.4	-1.0	-0.6	-2.0	-2.4
Handedness (chirality/laterality): Left-handed	1.6	2.0	4.2	-0.7	2.0	-1.7	-1.3	-0.8
Irritability	1.6	2.8	9.0	-1.0	-1.5	0.9	3.0	-0.9
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.5	-1.6	1.2	-0.4	-1.3	-1.5
Heart attack	1.5	2.0	2.8	1.7	1.6	0.9	1.0	1.6
Glaucoma (self-reported)	1.5	1.8	8.2	0.1	0.7	0.5	2.9	0.1
Medication for cholesterol	1.5	2.3	9.7	0.8	-0.0	-0.6	-3.1	0.7
Hand grip strength (right)	1.4	3.8	10.6	-1.2	-2.0	-0.9	-3.3	-1.3
Nervous feelings	1.4	2.6	5.6	1.1	-2.4	-1.7	-1.4	1.1
Mean time to correctly identify matches	1.4	2.7	4.6	2.1	1.7	0.3	-1.2	2.1
Average weekly champagne plus white wine intake	1.4	2.0	4.0	0.3	-1.6	2.0	1.7	0.2
Age started oral contraceptive pill	1.4	1.8	7.9	-0.3	-2.8	-0.9	-0.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.1	-0.8	-1.4	0.0	2.3	-0.7
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.0	1.7	1.5	0.9	0.7	1.7
Ulcerative Colitis	1.3	1.9	3.2	1.5	0.8	1.8	0.6	1.7
Height	1.3	24.8	49.7	-3.5	-4.0	-5.0	-7.0	-4.6
Hand grip strength (left)	1.3	3.5	8.2	-1.4	-2.1	-1.1	-2.9	-1.4
Systolic blood pressure, automated reading	1.3	3.8	6.8	2.5	-0.6	-0.2	2.4	2.6
Allergy	1.3	3.1	12.3	0.5	-1.1	1.0	3.5	0.9
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.5	-1.5	-0.5	-1.2	-1.6	-1.4
Ever highly irritable/argumentative for 2 days	1.3	1.5	3.6	-1.3	1.9	-0.3	-0.7	-1.3
Alcohol intake frequency.	1.3	3.1	11.1	-1.2	-0.7	1.1	3.3	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	7.1	0.2	2.7	-0.3	-1.7	-0.2
Medication: Blood pressure	1.3	2.4	9.4	0.2	1.4	0.7	3.1	0.2
Depressed Affect (Nagel 2018)	1.2	2.5	5.4	-1.7	1.2	2.3	0.9	-1.5
Smoking Status	1.2	2.8	13.0	0.3	3.6	0.8	0.0	0.4
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.9	-1.1	2.0	0.8	-0.3	-0.8
Stomach or abdominal pain in last month	1.2	1.5	3.2	0.3	1.8	1.7	1.1	0.4
Time employed in main current job	1.2	1.4	3.5	1.9	-0.2	-0.2	0.6	1.7
Number of live births	1.2	1.6	3.8	2.0	0.5	-0.5	0.1	2.0
Comparative height size at age 10	1.2	6.8	16.4	-1.8	-0.8	-2.9	-4.0	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	1.8	1.4	-0.7	-1.4	1.0	1.3
Tinnitus: Yes, now most or all of the time	1.2	1.5	4.2	-0.0	2.1	1.1	1.4	0.1
Diastolic blood pressure, automated reading	1.2	3.8	7.1	2.7	-0.2	1.0	1.9	2.7
Alcohol drinker status: Previous	1.2	1.3	2.5	-1.0	1.1	0.9	1.6	-1.0
Major Depression (MDD)	1.1	1.3	6.2	-0.4	2.5	0.1	-0.5	-0.1
HDL Cholesterol	1.1	1.9	3.9	2.0	1.5	-0.4	0.1	1.7
Rheumatoid Arthritis	1.1	1.5	3.3	-1.2	-1.8	1.3	0.1	-1.1
Ever had hysterectomy (womb removed)	1.1	1.3	2.7	1.5	1.1	-0.0	0.6	1.6
Severe depression (siblings)	1.1	1.3	3.5	-1.9	-0.1	0.1	-0.2	-1.7
Fed-up feelings	1.1	2.0	3.3	-1.7	-0.7	0.9	1.6	-1.8
Financial difficulties in last 2 years	1.1	1.5	2.0	-1.3	1.4	-1.3	0.0	-1.4
Standing height	1.1	11.3	29.9	-1.8	-2.6	-3.3	-5.5	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.2	0.0	-1.0	1.6	2.3	0.3
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.3	-1.8	-0.0	0.6	-0.5	-1.7
Supplements: Vitamin C	1.1	1.3	3.3	-1.3	-0.2	0.1	-1.8	-1.2
Mood swings	1.1	2.1	6.6	-1.1	-0.4	2.6	1.3	-0.9
Osteoporosis (self-reported)	1.1	1.4	4.7	0.6	-2.2	-1.0	0.7	0.4
Guilty feelings	1.1	1.7	4.0	-2.0	-0.8	-0.8	0.6	-1.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.4	0.8	-0.7	-0.4	2.3	0.5
Vitamin and mineral supplements	1.0	1.4	6.6	0.1	0.3	0.4	2.6	0.3
Serious illness, injury or assault to yourself	1.0	1.2	3.8	-0.2	2.0	-0.9	1.1	-0.4
Chronic bronchitis/emphysema (father)	1.0	1.2	2.7	-1.6	0.3	-1.0	0.2	-1.5
Had other major operations	1.0	1.2	2.6	0.9	1.0	-1.6	-1.0	0.7
Fluid intelligence score	1.0	2.0	4.4	-2.1	-0.1	-0.6	-1.1	-2.0
Happiness	1.0	1.2	3.1	-0.4	1.2	1.8	1.0	-0.6
Lung cancer (father)	1.0	1.1	2.3	1.2	-1.2	0.5	0.4	1.5
Exposure to tobacco smoke at home	1.0	1.2	2.9	-1.7	-0.2	-0.8	0.4	-1.5
Birth weight of first child	1.0	1.8	5.9	-0.2	-2.4	-0.9	-1.4	-0.5
Body fat percentage	1.0	4.0	13.6	-1.4	-1.4	1.1	3.7	-1.1
Pulse wave peak to peak time	1.0	1.2	2.9	0.1	-1.7	-0.7	-1.6	-0.1
Emphysema/chronic bronchitis	1.0	1.1	2.1	0.7	1.4	1.0	-1.3	0.6
Leg fat mass (right)	1.0	3.7	10.4	-1.6	-0.9	1.8	3.2	-1.3
Eye problems/disorders: Cataract	1.0	1.2	1.8	-1.4	0.3	-0.8	-1.2	-1.4
Breast cancer (self-reported)	1.0	1.1	2.8	1.3	-0.5	-1.7	0.3	1.0
Financial situation satisfaction	1.0	1.2	2.2	0.9	1.5	0.4	1.3	0.9
Leg fat mass (left)	1.0	4.0	11.3	-1.5	-1.1	2.0	3.4	-1.2
Ulcerative Colitis (UC)	0.9	1.7	2.4	1.5	1.4	1.2	0.1	1.5
Triglycerides	0.9	1.5	5.3	-0.1	0.7	1.2	2.3	0.1
Pack years adult smoking proportion	0.9	1.3	6.1	-0.4	2.5	-0.4	-0.4	-0.1
Qualifications: CSEs or equivalent	0.9	1.2	3.0	1.7	-0.3	0.3	-0.1	1.7
Supplements: Glucosamine	0.9	1.1	2.2	0.2	-1.4	-1.5	-1.2	-0.0
Falls in the last year	0.9	1.2	2.6	1.5	0.6	0.7	0.1	1.6
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.8	0.6	-1.9	-0.8	-0.4	0.7
Eye problems/disorders: None of the above	0.9	1.0	1.3	1.1	-0.8	1.0	1.2	1.0
Neck or shoulder pain in last month	0.9	1.3	3.6	1.0	1.9	-0.5	0.3	1.3
Migraine (self-reported)	0.9	1.2	2.8	0.3	0.4	1.6	1.7	0.6
Medication: Omeprazole	0.9	1.0	2.8	-1.0	-0.6	-0.7	1.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.7	-0.2	0.4	-1.1	1.9	-0.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.4	0.7	-1.8	0.3	-1.2	0.4
Illnesses of siblings: Diabetes	0.9	1.1	1.6	1.2	-0.9	-0.5	1.2	1.2
Arm fat percentage (left)	0.9	3.6	13.0	-1.2	-0.9	1.4	3.6	-0.9
Bipolar Disorder or Schizophrenia	0.8	2.0	4.1	-1.9	0.8	-0.9	0.7	-2.0
Irritable Bowel Disease (IBD)	0.8	1.9	4.0	1.4	2.0	0.8	0.2	1.7
Lung FVC	0.8	4.3	10.3	2.6	1.9	0.5	-0.0	3.2
Chronotype (morning person)	0.8	1.9	3.3	1.8	-1.1	-1.5	-0.4	1.5
Hearing difficulty/problems: Yes	0.8	1.2	5.2	0.5	0.2	0.4	2.3	0.5
Relative age of first facial hair	0.8	1.6	3.2	1.7	-0.3	-1.4	0.1	1.8
Trunk fat percentage	0.8	3.2	9.8	-1.2	-1.8	0.6	3.1	-1.0
Average weekly fortified wine intake	0.8	1.0	2.3	0.9	-0.6	1.5	0.7	1.0
Relative age voice broke	0.8	1.2	1.9	1.1	-0.3	-1.1	-1.4	1.2
Body mass index (BMI)	0.8	3.5	10.4	-0.6	-0.7	2.4	3.2	-0.4
Hearing difficulty/problems with background noise	0.8	1.2	2.8	-0.5	0.7	1.5	1.7	-0.5
Medication: Simvastatin	0.8	1.2	2.2	-1.5	-0.2	0.2	1.2	-1.5
Impedance of arm (right)	0.8	3.8	16.0	0.4	-0.6	-4.0	-1.5	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.4	-0.0	1.7	-1.8	-0.1	-0.3
Noisy workplace	0.8	1.0	2.4	0.1	1.6	0.7	1.5	-0.0
Asthma	0.8	1.6	4.2	-1.8	-0.5	0.6	-0.1	-2.1
Prospective memory result	0.8	1.0	2.2	-1.4	0.2	1.0	-0.0	-1.5
Illnesses of mother	0.8	0.9	2.2	1.5	0.2	-0.6	0.1	1.5
Medication: Paracetamol	0.8	1.3	2.0	1.2	1.1	1.0	0.9	1.4
Medication: Ibuprofen	0.8	0.9	2.7	-0.6	1.1	1.6	-0.3	-0.4
Age at last live birth	0.8	1.2	3.2	-0.9	-0.2	-0.4	-1.8	-1.2
Asthma (self-reported)	0.8	1.6	4.1	-1.8	-0.4	0.9	-0.3	-2.0
Ever taken oral contraceptive pill	0.8	0.9	2.3	-1.3	0.0	-0.2	0.8	-1.5
Hearing aid user	0.8	0.9	1.5	-1.2	0.9	0.2	0.7	-1.2
Medication: Bendroflumethiazide	0.8	1.3	2.6	-1.3	-0.2	-0.3	1.6	-1.3
Ever smoked	0.8	1.5	6.6	-0.3	2.6	-0.4	-0.1	-0.7
Reaction Time	0.7	1.4	2.2	1.5	1.1	0.1	-1.4	1.3
Lupus	0.7	1.1	3.4	0.1	1.3	1.9	0.7	0.2
Sitting height	0.7	5.3	14.6	-1.2	-2.1	-1.9	-3.8	-1.5
Trunk fat mass	0.7	2.9	5.2	-1.5	-2.1	0.8	2.3	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.7	0.9	0.5	-1.6	-1.1	0.9
Forced vital capacity (FVC)	0.7	2.5	9.4	0.8	-1.4	-0.0	-3.1	0.8
Arm fat percentage (right)	0.7	2.9	11.6	-0.7	-0.8	1.3	3.4	-0.3
Pulse wave Arterial Stiffness index	0.7	0.8	2.6	-0.3	1.6	0.3	1.0	-0.2
Peak expiratory flow (PEF)	0.7	1.7	2.9	-1.2	-1.2	-1.4	-1.7	-1.0
Exposure to tobacco smoke outside home	0.7	0.9	2.0	-1.4	-0.4	-1.0	-0.1	-1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	0.8	0.9	-0.1	-1.3	0.8
Medication: Allopurinol	0.7	0.9	1.5	-1.2	-0.0	0.6	1.2	-1.1
Family relationship satisfaction	0.7	0.8	2.0	-1.3	0.5	0.5	-0.2	-1.4
Average weekly red wine intake	0.7	1.1	2.6	-1.6	-0.1	-0.4	-0.5	-1.6
Arm fat mass (left)	0.7	2.8	5.6	-1.6	-1.2	1.6	2.4	-1.4
Miserableness	0.7	1.3	3.0	-0.7	1.4	1.7	0.3	-0.8
Wears glasses or contact lenses	0.7	0.8	1.7	-0.3	1.1	0.9	1.3	-0.3
Alcohol drinker status: Never	0.7	0.9	1.9	-0.7	0.5	1.2	1.4	-0.5
Vascular/heart problems diagnosed by doctor	0.7	2.0	6.7	-0.6	-1.5	0.1	-2.6	-0.9
Cholesterol lowering medication	0.7	1.1	4.7	-0.5	0.1	0.5	2.2	-0.5
Pain experienced in last month	0.7	1.2	2.5	0.6	-1.6	1.5	0.7	0.6
Supplements: Calcium	0.7	0.7	1.5	1.2	-0.2	-0.2	0.9	1.0
Crohns Disease (2012)	0.6	0.9	2.8	0.9	1.7	0.1	-0.2	1.0
LDL Cholesterol	0.6	0.9	1.8	-1.3	1.0	-0.9	-0.3	-1.1
Neuroticism (2016)	0.6	0.9	2.8	0.8	0.5	0.6	1.7	0.7
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.7	-0.5	-0.1	-1.1	1.3	-0.3
Blood Platelet Count	0.6	7.3	15.1	3.5	-2.2	-1.3	-1.5	3.9
Heel T-Score	0.6	4.9	19.8	-1.3	-1.4	0.9	4.5	-0.7
Cardiovascular Disease	0.6	2.1	6.0	0.3	2.0	-0.1	2.5	0.6
Number of treatments/medications taken	0.6	1.2	2.0	-1.4	-0.9	0.4	1.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.3	0.9	-1.1	-0.4	-0.8	0.9
Hair/balding pattern: Pattern 2	0.6	0.7	2.3	-0.7	-0.1	-1.5	-0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.7	-1.7	0.2	-1.3	-0.3	-1.5
Mouth/teeth dental problems	0.6	1.0	2.2	-0.6	-0.9	1.0	1.5	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.0	0.2	1.4	1.3	0.1	0.4
Impedance of arm (left)	0.6	2.8	12.7	-0.4	-0.7	-3.6	-0.9	-0.4
Arm fat mass (right)	0.6	2.6	6.0	-1.1	-1.4	1.6	2.4	-1.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.5	1.0	0.8	1.2	-0.2	1.0
High blood pressure (siblings)	0.6	0.9	1.9	1.3	0.2	-0.2	1.0	1.4
Medication for pain relief, constipation, heartburn	0.6	1.0	2.4	-0.4	-1.1	-1.0	-1.6	-0.5
Medication: Seretide 50 evohaler	0.6	0.7	3.0	0.2	1.7	0.5	-0.5	0.0
Whole body fat mass	0.6	2.7	6.8	-1.2	-1.7	1.1	2.6	-1.1
Overall health rating	0.6	1.3	3.6	0.6	1.2	0.8	1.9	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.6	-0.5	1.6	0.1	0.2	-0.6
Back pain experienced in last month	0.6	0.9	4.0	0.4	2.0	-0.1	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.3	0.8	-1.5	1.5	0.0	1.2
Mother’s age at death	0.6	0.8	2.4	-0.6	-1.6	0.7	-0.6	-0.6
Eye problems/disorders: Glaucoma	0.6	0.7	2.8	0.0	0.8	-0.1	1.7	0.1
Medication: Paracetamol	0.6	0.9	1.7	1.0	1.1	0.7	0.3	1.3
Medication: Atorvastatin	0.6	0.8	3.3	0.2	-0.1	0.5	1.8	0.5
Illnesses of father: High blood pressure	0.6	0.7	1.7	1.3	0.2	-0.9	0.1	1.0
Fractured/broken bones in last 5 years	0.6	0.8	1.6	-0.1	1.2	-1.3	-1.0	-0.1
Unable to work because of sickness or disability	0.6	0.8	2.3	0.7	1.5	-0.1	-0.8	0.7
Pack years of smoking	0.6	0.9	3.6	-0.4	1.9	-0.5	-0.4	-0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	-1.0	-0.5	0.6	0.2	-1.1
Crohns Disease (2017)	0.5	1.0	3.0	0.8	1.7	0.0	0.3	1.1
Prostate Cancer	0.5	0.7	1.7	-0.2	1.1	0.5	-1.3	-0.4
Age at First Birth	0.5	0.8	2.0	0.9	0.8	-0.3	-1.4	0.6
Fasting Glucose	0.5	0.6	2.6	-0.1	1.6	-0.1	0.6	-0.1
HbA1C	0.5	0.5	1.2	-1.1	0.3	-0.7	0.5	-0.7
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.7	-0.5	-0.4	1.3	1.6	-0.4
Supplements: Zinc	0.5	0.6	2.2	0.5	0.2	-0.5	-1.5	0.2
High blood pressure	0.5	1.4	5.9	-0.3	0.9	-0.6	2.4	-0.0
Medication: Atenolol	0.5	0.6	2.0	0.4	1.4	0.7	0.2	0.6
Had menopause	0.5	0.6	1.3	1.1	0.8	-0.3	0.3	1.0
Medication: Ramipril	0.5	0.6	2.0	0.4	0.1	-1.4	0.9	0.5
Trunk fat-free mass	0.5	2.8	7.2	-1.3	-1.3	0.9	-2.7	-1.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	4.1	0.3	-2.0	0.6	-1.7	0.3
Trunk predicted mass	0.5	2.9	7.1	-1.4	-1.3	0.9	-2.7	-1.7
Breastfed as a baby	0.5	0.6	2.7	0.2	1.7	0.3	0.5	0.1
Qualifications: College or University degree	0.5	1.5	4.1	-1.6	-0.5	0.7	-0.6	-2.0
Heart disease (mother)	0.5	0.6	1.7	-0.1	1.3	0.6	-0.9	0.1
Arm predicted mass (right)	0.5	2.6	4.7	-1.8	-1.4	1.4	-1.1	-2.2
Pulse rate, automated reading	0.5	1.6	3.4	-1.9	-0.1	-1.5	0.0	-1.4
Number of full sisters	0.5	0.6	1.5	-0.0	1.2	-0.1	-1.1	-0.1
Leg pain on walking	0.5	0.6	1.3	-0.4	1.0	-1.1	0.5	-0.5
Hypertension (Self-reported)	0.5	1.3	4.2	0.3	0.9	-1.2	2.0	0.4
Medication: Gliclazide	0.5	0.6	1.5	0.1	0.6	0.9	1.2	0.4
Medication: Lisinopril	0.5	0.7	1.5	-0.6	1.1	0.5	1.2	-0.4
Number of operations (self-reported)	0.5	0.7	1.8	0.1	1.0	-1.0	-1.4	-0.1
Commuting to job workplace: Cycle	0.5	0.6	1.4	-1.0	-0.5	-0.6	-0.6	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.3	-0.6	1.5	-0.1	-0.6	-0.6
Heart disease (siblings)	0.5	0.6	1.8	0.3	-0.3	1.0	1.3	0.3
Depression (Nagel 2018)	0.4	0.6	1.3	-1.0	1.1	0.2	-0.1	-0.8
Neuroticism (Nagel 2018)	0.4	1.0	2.1	-1.2	-0.4	0.7	1.5	-0.8
Worry (Nagel 2018)	0.4	0.8	1.7	0.3	-1.3	-1.2	0.6	0.7
Ovarian Cancer	0.4	0.5	1.4	0.5	0.7	1.2	-0.4	0.2
Schizophrenia (2014)	0.4	1.0	1.6	-1.2	0.6	0.9	1.0	-1.1
Blood Eosinophil Count	0.4	2.8	6.6	-1.7	1.5	2.6	-0.7	-1.4
BMI	0.4	2.2	5.0	1.0	-1.1	1.5	2.2	1.2
Waist Hip Ratio (WHR)	0.4	1.7	4.7	-2.2	0.1	-0.1	-0.3	-1.9
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.3	0.4	1.1	1.0	0.3	0.4
Angina	0.4	0.5	0.7	0.7	-0.1	-0.8	0.8	0.7
Medication for hormone replacement therapy	0.4	0.5	1.4	-1.2	0.3	-0.1	0.1	-0.9
Diabetes (mother)	0.4	0.5	1.4	-0.7	0.2	0.4	1.2	-0.8
Taking other prescription medications	0.4	0.6	1.8	0.0	0.8	1.4	0.7	0.4
Multivitamins +/- minerals	0.4	0.4	1.5	0.7	0.2	-0.4	-1.2	0.3
Medication: Levothyroxine sodium	0.4	0.6	1.4	1.1	0.0	0.7	0.2	1.2
Number of incorrect matches in round	0.4	0.6	2.6	0.4	-0.1	0.4	-1.6	0.6
Neuroticism score	0.4	0.8	2.0	-0.7	-1.0	0.5	1.4	-0.6
Weight	0.4	1.9	3.3	-1.5	-1.8	0.8	0.7	-1.6
Father’s age at death	0.4	0.5	0.8	-0.9	-0.4	0.6	0.6	-0.9
Worrier / anxious feelings	0.4	0.8	3.1	-0.1	1.8	-0.9	-0.4	0.3
Pulse rate	0.4	0.7	1.5	-0.9	-0.6	-0.7	1.2	-0.7
Medication: Cholesterol lowering	0.4	0.7	2.0	-0.6	1.4	0.4	0.8	-0.4
Depression (self-reported)	0.4	0.4	1.1	-0.2	-0.5	0.9	1.0	0.0
Tense / ‘highly strung’	0.4	0.7	1.1	0.9	-0.7	-0.8	0.5	1.0
Blood clot in the leg (DVT)	0.4	0.5	1.2	-0.7	1.1	-0.2	-0.4	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.0	0.5	-1.4	-0.0	-0.9	0.1
Forced vital capacity (FVC), Best measure	0.4	1.6	5.3	0.6	-1.2	-0.4	-2.3	0.7
Arm fat-free mass (right)	0.4	2.3	3.6	-1.6	-1.5	1.6	-0.8	-1.9
Comparative body size at age 10	0.4	1.1	3.0	0.8	-0.7	1.0	1.7	0.6
Worry too long after embarrassment	0.4	0.7	1.5	-0.2	-1.2	-0.9	1.0	-0.2
Wheeze or whistling in the chest in last year	0.4	0.7	2.4	-0.0	1.6	0.9	0.5	-0.2
Age at first live birth	0.4	0.7	2.2	-0.3	0.1	-0.6	-1.5	-0.9
Shortness of breath walking on level ground	0.4	0.5	2.0	-0.6	1.4	-0.1	0.2	-0.4
Suffer from ‘nerves’	0.4	0.6	2.1	0.1	-0.7	-1.4	0.4	0.1
Had major operations	0.4	0.5	1.2	-0.6	0.7	-0.3	-1.1	-0.7
Medication: Aspirin	0.4	0.5	2.1	-0.2	0.6	-0.2	1.4	-0.4
Whole body fat-free mass	0.4	2.3	4.7	-1.2	-1.6	0.6	-2.2	-1.6
Friendships satisfaction	0.4	0.5	1.0	-0.5	1.0	0.1	-0.7	-0.8
Medication: Aspirin	0.4	0.5	1.4	0.0	0.8	-0.4	1.2	-0.3
Whole body water mass	0.4	2.2	4.6	-1.2	-1.4	0.7	-2.1	-1.6
Basal metabolic rate	0.4	2.0	2.9	-1.4	-1.7	0.8	-1.3	-1.7
Arm fat-free mass (left)	0.4	1.9	2.6	-1.4	-1.3	1.6	-0.9	-1.6
Average weekly beer plus cider intake	0.4	0.6	1.1	0.9	0.2	-0.6	-0.7	1.1
Arm predicted mass (left)	0.4	2.2	3.0	-1.5	-1.5	1.2	-1.4	-1.7
Schizophrenia vs Biploar Disorder	0.3	0.5	0.9	1.0	0.5	0.7	-0.5	0.6
Alzheimer’s Disease (in father)	0.3	0.4	0.8	0.6	0.9	-0.7	-0.1	0.4
Breast Cancer	0.3	0.8	1.9	-0.9	-0.7	1.4	-0.7	-0.3
Body Mass Index (BMI) (2010)	0.3	0.4	0.6	0.4	-0.7	0.8	-0.6	0.3
Coronary Artery Disease (CAD)	0.3	0.3	0.5	-0.4	0.4	-0.7	0.7	-0.7
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.7	-0.1	0.9	-0.6	0.8
Systolic Blood Pressure	0.3	1.4	6.4	0.5	-0.2	0.3	2.5	0.6
Hypothyroidism (self reported)	0.3	0.7	1.2	0.9	0.8	-0.1	-1.1	1.0
Respiratory disease	0.3	0.6	1.4	-0.4	1.0	1.2	-0.6	-0.4
Medication: Metformin	0.3	0.4	0.7	0.6	0.0	-0.6	0.9	0.8
Leg fat-free mass (left)	0.3	1.7	3.1	-1.2	-1.8	0.0	-1.3	-1.6
Leg predicted mass (left)	0.3	1.8	3.2	-1.2	-1.8	0.1	-1.3	-1.6
Diabetes (self-reported)	0.3	0.4	0.8	-0.8	-0.4	-0.0	0.9	-0.7
Alcohol intake versus 10 years previously	0.3	0.4	1.5	-0.5	-1.2	-0.2	0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.4	-0.2	0.6	1.2	-0.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	-0.8	0.7	0.2	-0.5	-0.7
Medication: Blood pressure	0.3	0.6	1.7	0.2	0.7	-1.3	0.5	0.5
Angina (self-reported)	0.3	0.4	0.7	0.8	-0.1	-0.8	0.6	0.7
Knee pain experienced in last month	0.3	0.4	1.1	0.6	-0.6	-0.1	1.0	0.5
Leg fat-free mass (right)	0.3	1.5	3.0	-0.8	-1.7	0.2	-1.2	-1.4
Leg predicted mass (right)	0.3	1.6	3.0	-0.9	-1.7	0.2	-1.4	-1.4
Commuting to job workplace: Public transport	0.3	0.3	1.4	-0.2	0.3	1.2	-0.2	-0.4
High cholesterol (Self-reported)	0.3	0.5	2.1	-0.0	1.5	0.1	0.6	0.0
Impedance of whole body	0.3	1.6	7.4	-0.4	-0.6	-2.7	-0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	-0.8	0.7	0.6	-1.0	-0.8
Blood White Count	0.2	1.5	3.3	0.8	-0.8	0.9	-1.8	1.4
Neuroticism	0.2	0.5	1.4	-1.2	-0.1	-0.3	0.4	-1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.1	0.0	1.1	-0.2	-0.5	-0.2
Medication: Co-codamol	0.2	0.2	0.5	-0.5	0.2	-0.7	0.2	-0.3
Diabetes (father)	0.2	0.3	0.7	0.2	0.4	-0.9	-0.5	0.3
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.6	0.7	-0.7	-0.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.1	0.8	-0.6	-0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-1.0	0.2	-0.6	0.5	-0.7
Waist circumference	0.2	0.6	1.4	-0.7	-0.5	1.2	0.7	-0.6
Past tobacco smoking	0.2	0.4	1.7	-0.0	-1.3	-0.2	-0.2	0.3
Alcohol usually taken with meals	0.2	0.3	1.2	-0.4	-0.3	1.1	-0.2	-0.3
Pain all over the body in last month	0.2	0.2	0.8	0.0	0.6	-0.9	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.2	-0.0	-1.8	0.4	-0.6	0.1
Gout (self-reported)	0.2	0.3	1.3	0.3	-0.2	0.2	1.1	0.3
Birth weight	0.2	0.5	1.3	0.2	-1.2	1.0	0.3	0.3
Number of full brothers	0.2	0.2	1.0	0.1	-0.2	1.0	0.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	0.3	-0.2	-0.0	0.7	0.6
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.8	-0.5	-0.2	0.3	-0.7
Smoking status: Previous	0.2	0.3	0.7	-0.7	0.0	0.3	0.3	-0.8
Loneliness, isolation	0.2	0.3	1.2	0.1	1.1	0.6	0.2	0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.3	0.5	0.5	0.8	0.2
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.8	-0.6	0.1	0.4	-0.8
Qualifications: nursing, teaching	0.2	0.4	1.1	0.3	0.4	0.6	1.0	0.3
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.4	-0.6	-0.8	0.3	0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	0.4	-0.4	0.3	0.8	0.5
Number of self-reported non-cancer illnesses	0.2	0.3	1.2	0.2	0.3	0.3	1.1	0.1
Schizophrenia (2018)	0.1	0.3	0.6	-0.2	0.7	0.6	0.8	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	-0.4	0.5	0.4	0.6	-0.6
Hair Pigment	0.1	1.9	3.3	1.7	0.2	0.7	1.8	1.7
Tanning	0.1	1.0	4.5	-0.0	-0.0	0.8	2.1	-0.2
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.1	-0.7	0.4	-0.3	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.3	0.6	-0.0	0.3	-0.1
Impedance of leg (right)	0.1	0.7	1.9	-1.0	0.6	-1.4	0.4	-0.4
Maternal smoking around birth	0.1	0.1	0.4	-0.6	-0.1	0.2	-0.1	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.3	-0.4	0.2	-0.4	-0.0
Impedance of leg (left)	0.1	0.4	0.9	-0.7	0.3	-0.6	1.0	-0.2
Qualifications: None of the above	0.1	0.3	0.9	-0.4	-0.6	-0.1	1.0	-0.2
Illnesses of siblings	0.1	0.2	0.6	-0.2	-0.7	0.2	-0.3	-0.5
Hip circumference	0.1	0.3	0.9	-0.4	-0.9	0.3	-0.0	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.2	0.1	1.1	0.3	-0.2	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	-0.1	-0.8	-0.4	0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.5	0.6	0.5	0.0	0.5
Medication: Amlodipine	0.1	0.2	0.6	0.2	-0.1	-0.5	0.8	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.4	0.2	-0.2	-0.2	-0.4
Myopia	0.1	0.1	0.3	-0.2	-0.5	-0.3	0.4	-0.1
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.1	0.4	0.1	0.1	-0.2
Blood Red Count	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.3	0.2

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Trait associations