Hub : Genes

SLCO2B1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.096	0.0410	0.00570	-0.001	0.015	0.008	0.02	0.001	5.0e-01	0.0054	3.6e-02	0.0015	2.6e-01
2	GTEx	Esophagus Mucosa	0.148	0.0530	0.00012	0.016	NA	0.015	NA	0.027	3.0e-02	NA	3.1e-02	NA	5.9e-03
3	GTEx	Testis	0.279	0.0770	0.00002	0.111	NA	0.136	NA	0.152	1.3e-05	NA	1.3e-06	NA	2.9e-07
4	TCGA	Prostate Adenocarcinoma	0.040	0.0244	0.00690	0.007	0.009	-0.002	NA	0.001	5.5e-02	0.0330	7.8e-01	NA	2.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	2.8	1.7	0.7	0.3	0.9
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	0.2	-0.6	1.0	0.1
Depressed Affect (Nagel 2018)	1.7	3.6	7.7	-0.7	2.8	0.2	2.5
Depression (Nagel 2018)	0.8	1.2	2.4	0.4	1.2	0.9	1.6
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.5	-0.4	-1.2	0.9	-1.6
Neuroticism (Nagel 2018)	1.3	3.0	7.2	-0.1	2.2	0.3	2.7
Schizophrenia (2018)	0.6	1.2	1.9	-1.2	-1.4	1.1	-0.6
Schizophrenia vs Biploar Disorder	0.9	1.2	2.9	-0.3	-0.5	1.7	-1.2
Worry (Nagel 2018)	1.2	2.6	4.9	1.4	1.8	-0.6	2.2
Alzheimer’s Disease (in mother)	1.0	1.1	3.4	1.8	0.6	-0.8	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.1	-0.2	0.4	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.8	-0.5	-0.5	0.3
Crohns Disease (2017)	2.8	6.2	16.1	0.0	-4.0	1.1	-2.7
Irritable Bowel Disease (IBD)	0.9	2.1	6.1	0.9	-2.5	0.5	-1.2
Ulcerative Colitis (UC)	0.4	0.8	2.2	1.5	0.1	-0.4	0.9
Major Depression (MDD)	0.6	0.7	2.2	-0.4	0.0	1.5	-0.6
Reaction Time	0.2	0.4	1.1	1.0	0.3	0.2	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.2	1.1	-0.6	0.1	-0.7
Breast Cancer	1.2	2.9	6.4	-0.5	2.5	-1.1	2.0
Ovarian Cancer	0.2	0.2	0.8	-0.2	-0.1	0.9	-0.1
Prostate Cancer	0.2	0.3	0.5	0.6	0.6	-0.1	-0.7
Age at First Birth	1.7	2.4	7.1	-2.7	0.9	-1.2	0.7
Bipolar Disorder (2011)	0.5	0.4	1.2	0.8	0.1	1.1	-0.0
Body Mass Index (BMI) (2010)	1.4	1.9	3.0	0.4	-1.4	1.5	-1.7
Coronary Artery Disease (CAD)	2.7	3.2	5.7	-1.7	-2.4	-0.7	-1.9
Crohns Disease (2012)	2.6	4.1	11.1	-0.9	-3.3	0.5	-2.1
Mean Putamen Volume	0.8	0.9	1.8	-0.6	-1.3	1.2	-0.1
Fasting Glucose	0.3	0.3	0.6	0.8	-0.2	0.5	-0.7
HbA1C	0.4	0.4	0.8	0.9	0.5	0.5	-0.6
HDL Cholesterol	0.1	0.2	0.4	0.7	0.4	-0.1	-0.5
LDL Cholesterol	1.4	2.2	3.4	-1.8	-1.8	0.0	-1.4
Lupus	0.9	1.4	2.2	-0.8	1.0	-1.5	1.4
Neuroticism (2016)	0.5	0.8	1.7	-1.3	0.4	1.1	0.2
Primary Biliary Cirrhosis	1.1	1.5	4.7	-0.7	-0.8	2.2	0.6
Rheumatoid Arthritis	0.4	0.6	1.2	-0.4	0.9	-1.1	-0.6
Schizophrenia (2014)	0.8	1.7	5.1	-0.2	-1.3	2.3	-0.4
Triglycerides	0.4	0.6	1.8	-0.4	-1.4	0.4	0.5
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.7	0.8	1.1	0.6	1.6
Ulcerative Colitis	0.4	0.6	1.3	1.1	0.0	0.4	1.1
Blood Eosinophil Count	0.3	2.2	4.8	2.2	1.4	-0.7	-1.3
Blood Platelet Count	0.1	1.1	3.4	-0.2	-0.6	0.7	-1.9
Blood Red Count	0.6	5.6	9.3	2.3	-2.2	3.0	-1.8
Blood White Count	0.4	3.2	6.2	1.4	-1.4	1.7	-2.5
Heel T-Score	0.7	5.6	18.3	4.3	-0.5	1.9	0.0
BMI	0.5	2.7	6.5	-0.8	-1.9	0.7	-2.5
Height	1.4	27.1	56.1	-6.7	2.4	-7.5	1.5
Waist Hip Ratio (WHR)	0.7	3.1	6.1	0.2	-1.7	1.9	-2.5
Systolic Blood Pressure	0.3	1.3	3.9	-0.5	-1.0	2.0	-0.4
Smoking Status	0.4	1.0	1.8	-1.4	-0.7	-0.2	-1.2
Allergy or Eczema	0.8	2.1	4.1	-0.2	2.0	-1.6	1.3
Cardiovascular Disease	1.6	5.1	7.2	-0.2	-2.5	2.7	-2.6
Hypothyroidism (self reported)	0.7	1.6	3.7	-0.7	1.3	-1.9	0.7
Respiratory disease	0.6	1.3	2.8	1.7	1.2	-0.8	0.3
Type 2 Diabetes (T2D) (2018)	1.3	2.4	5.2	-0.8	-2.0	0.1	-2.3
Lung FEV1/FVC ratio	0.5	2.3	8.6	-0.0	0.2	-2.9	0.8
Lung FVC	0.6	3.0	11.7	-0.4	-0.4	3.4	-0.4
Neuroticism	1.4	3.4	6.2	1.4	2.5	-0.4	2.3
Chronotype (morning person)	0.9	2.2	3.9	-2.0	-1.5	-0.4	-1.5
Hair Pigment	0.0	0.8	1.2	-0.6	0.8	-1.1	0.9
Tanning	0.2	2.4	4.9	0.9	-2.2	1.2	-1.4
Hand grip strength (left)	0.8	2.1	3.3	-1.8	-0.8	-1.8	-1.1
Number of treatments/medications taken	0.1	0.2	0.4	-0.6	-0.0	-0.1	0.6
Average weekly spirits intake	0.5	0.6	1.0	0.9	0.7	-0.3	-1.0
Sensitivity / hurt feelings	0.5	0.9	3.2	0.0	-0.2	1.8	0.6
Frequency of depressed mood in last 2 weeks	1.4	2.0	4.2	0.2	1.9	-0.4	2.1
Hearing difficulty/problems: Yes	0.2	0.3	1.1	-1.1	-0.1	-0.4	-0.1
Relative age of first facial hair	2.7	5.5	9.1	1.2	3.0	-2.7	2.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.5	-0.1	-0.3	-0.7	-1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.6	-1.2	0.6	-0.3	0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	-0.8	-0.4	-0.3	-0.1
Systolic blood pressure, automated reading	0.5	1.4	2.7	-1.0	-1.3	1.6	-0.7
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	2.2	-0.7	-1.0	1.2	-1.5
Angina	1.5	2.0	4.0	-2.0	-1.1	0.2	-1.6
Medication for hormone replacement therapy	1.1	1.2	2.5	0.0	1.6	-0.5	1.5
Vitamin and mineral supplements	0.8	1.0	1.9	-1.1	-0.9	-0.2	-1.4
Supplements: Zinc	0.7	0.7	1.4	0.7	0.2	1.0	1.2
Medication: Co-codamol	0.3	0.4	0.7	-0.2	0.4	-0.7	0.8
Medication: Metformin	3.8	5.4	10.7	-1.3	-3.3	1.3	-2.7
Diabetes (father)	0.4	0.5	1.5	-0.2	-1.2	-0.1	-0.6
Diabetes (mother)	1.1	1.4	2.1	1.2	1.5	-1.4	0.5
Severe depression (siblings)	0.8	0.9	1.8	0.4	1.1	-0.5	1.4
Pack years adult smoking proportion	1.0	1.6	4.0	-2.0	-1.5	-0.2	-0.4
Impedance of leg (right)	0.4	2.0	4.0	1.4	2.0	-0.4	1.4
Leg fat-free mass (left)	0.9	4.9	9.2	-3.0	0.1	-3.0	-1.3
Trunk fat percentage	0.7	3.0	6.7	-2.6	1.0	-2.0	-0.5
Hand grip strength (right)	1.4	3.9	7.8	-2.7	-0.3	-2.8	-0.3
Townsend deprivation index at recruitment	0.3	0.4	1.2	0.2	-0.2	1.1	-0.4
Current tobacco smoking	0.6	0.9	1.6	1.3	0.7	-0.9	0.9
Average weekly fortified wine intake	0.5	0.6	1.9	-1.4	-0.5	0.3	0.0
Maternal smoking around birth	1.7	2.4	5.7	-2.4	-1.2	1.1	-1.2
Fed-up feelings	0.9	1.6	3.2	-0.5	1.8	0.2	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	-0.1	-0.3	1.1	0.0
Relative age voice broke	0.2	0.2	0.5	-0.0	0.7	-0.3	-0.6
Taking other prescription medications	0.1	0.1	0.4	-0.2	-0.1	0.1	0.6
Age when periods started (menarche)	1.5	3.6	7.8	-1.4	1.2	-2.8	1.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.7	-0.4	1.6	-0.8	1.2
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.1	7.6	2.4	-2.8	2.5	-2.2
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.5	1.2	1.1	0.5	0.9
Qualifications: CSEs or equivalent	0.7	0.9	1.5	0.3	1.2	-0.9	1.1
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.4	-0.1	0.3	-0.3
High blood pressure	0.4	1.2	1.7	-1.3	-1.1	1.2	-0.4
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.7	0.3	1.7	-0.9	1.1
Multivitamins +/- minerals	2.1	2.7	5.4	0.5	2.1	-0.7	2.3
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.5	0.3	0.1	0.1
Supplements: Glucosamine	0.4	0.5	1.3	-0.1	1.1	0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.2	0.5	0.7	0.2
Medication: Atenolol	0.9	1.1	3.3	-1.8	-0.8	0.3	0.5
Medication: Levothyroxine sodium	0.6	1.0	3.8	-0.6	-0.1	-2.0	0.1
Sitting height	1.2	8.8	23.5	-3.1	1.2	-4.8	0.9
Chronic bronchitis/emphysema (father)	3.7	4.3	7.3	-1.5	-2.7	2.2	-1.7
High blood pressure (mother)	2.7	3.8	5.1	-1.1	-2.1	2.3	-2.1
Body mass index (BMI)	0.4	1.9	4.6	-2.1	-0.6	-0.9	-1.3
Impedance of leg (left)	0.6	2.8	5.6	1.0	2.4	-0.5	2.1
Leg predicted mass (left)	0.9	4.9	9.3	-3.1	0.1	-2.9	-1.4
Trunk fat mass	1.1	4.6	10.0	-3.2	0.8	-2.7	-0.9
Waist circumference	0.8	2.8	4.8	-2.2	0.2	-2.0	-1.5
Number of incorrect matches in round	1.0	1.7	4.5	-0.5	-0.5	2.1	-1.3
Past tobacco smoking	1.3	2.3	6.9	2.6	0.5	0.5	1.4
Alcohol usually taken with meals	0.7	1.2	3.4	1.8	-0.3	-1.1	-0.4
Nervous feelings	0.9	1.6	3.2	1.0	1.5	-0.2	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.8	0.1	1.9	0.3	1.7
Hearing difficulty/problems with background noise	0.3	0.4	0.9	-0.5	0.7	0.2	-0.9
Hair/balding pattern: Pattern 2	0.5	0.7	1.5	-0.1	0.5	-1.0	1.2
Had menopause	0.5	0.6	1.0	-0.8	0.9	-1.0	0.3
Had other major operations	4.1	5.1	7.1	2.7	2.5	-2.3	1.4
Forced vital capacity (FVC)	0.1	0.3	1.0	-0.1	1.0	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	2.7	6.1	8.4	2.3	-2.9	2.0	-2.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.3	0.1	0.6	-0.1	1.2
Qualifications: None of the above	0.2	0.4	1.1	-1.0	-0.4	0.5	0.2
Financial difficulties in last 2 years	1.9	2.5	3.7	-1.4	1.9	-1.8	1.2
Mouth/teeth dental problems	2.0	3.1	11.3	3.4	-0.9	0.3	-0.3
Heart attack	0.4	0.5	1.1	-1.1	0.5	-0.7	0.5
Allergy	1.1	2.6	6.0	-0.7	-2.5	1.4	-1.4
Pain all over the body in last month	0.7	0.7	2.2	-1.5	-0.6	0.2	0.5
Diabetes (self-reported)	1.9	3.0	5.2	-1.5	-2.3	0.2	-2.2
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.5	0.2	1.2	-0.0	1.6
Medication: Ramipril	0.6	0.8	2.2	-0.7	-0.8	0.1	-1.5
Medication: Simvastatin	3.5	5.1	8.0	-2.7	-2.2	0.4	-2.8
Fluid intelligence score	0.5	1.0	3.5	1.9	-0.5	-0.1	-0.5
Illnesses of siblings	0.3	0.4	0.8	0.9	0.8	-0.4	0.2
Neuroticism score	0.6	1.3	2.9	0.7	1.7	0.2	1.4
Weight	1.3	6.4	12.2	-3.5	0.7	-3.5	-1.0
Impedance of arm (right)	0.4	2.0	3.7	1.3	1.9	-0.9	1.4
Arm fat percentage (right)	0.4	1.5	3.5	-1.9	0.3	-1.2	-1.0
Trunk fat-free mass	1.0	5.5	11.6	-2.9	-0.1	-3.4	-1.4
Hip circumference	1.1	4.9	11.6	-2.5	1.0	-3.4	-0.8
Time employed in main current job	1.6	1.9	4.2	-0.2	-0.6	2.0	-1.7
Alcohol intake versus 10 years previously	0.7	1.1	2.7	-1.7	-0.3	0.1	-1.2
Father’s age at death	0.5	0.7	1.8	1.3	0.2	-1.0	-0.1
Worrier / anxious feelings	1.0	1.8	5.6	0.6	-0.7	2.4	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.0	1.4	1.2	0.4	1.7
Falls in the last year	0.6	0.8	1.6	-1.3	0.9	-0.6	0.6
Hair/balding pattern: Pattern 3	1.2	1.8	3.9	0.7	2.0	-1.4	1.0
Number of live births	0.5	0.7	1.4	-1.0	0.5	-1.2	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.9	0.4	0.7	-0.9	0.1
Pulse rate	0.4	0.6	1.6	0.3	1.3	0.1	0.8
Happiness	1.1	1.3	4.1	2.0	0.6	0.8	0.4
Noisy workplace	0.3	0.4	1.3	-1.1	0.6	-0.0	-0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.2	2.3	-0.2	0.2	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	-1.0	-1.2	0.6	-0.6
Mouth/teeth dental problems: Dentures	1.1	1.8	3.8	-2.0	1.1	-0.5	1.4
Asthma	0.5	0.9	3.2	0.0	1.8	-0.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	-0.0	0.4	0.6	-0.3
Medication: Cholesterol lowering	3.0	4.7	9.0	-1.8	-2.5	0.6	-3.0
Depression (self-reported)	2.3	2.8	5.3	1.6	1.6	-0.8	2.3
Medication: Lansoprazole	0.4	0.5	0.8	0.9	0.6	-0.9	0.2
Prospective memory result	0.0	0.0	0.0	0.2	0.0	0.1	-0.0
Lung cancer (father)	0.8	0.9	2.1	0.5	1.4	-1.1	0.1
Illnesses of mother	1.0	1.2	2.2	0.7	1.2	-0.8	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.4	-1.2	0.6	-0.5	0.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.4	-0.4	-1.2	0.9	0.1
Impedance of arm (left)	0.4	2.0	3.4	1.3	1.8	-0.7	1.5
Arm fat mass (right)	0.6	2.6	5.3	-2.3	0.2	-1.8	-1.3
Trunk predicted mass	1.0	5.6	11.4	-3.0	-0.1	-3.4	-1.4
Standing height	1.4	13.4	34.6	-3.5	2.6	-5.9	0.4
Length of working week for main job	1.6	1.7	3.2	0.8	0.6	-1.8	-1.6
Exposure to tobacco smoke at home	2.7	3.1	7.2	-1.2	1.4	-1.3	2.7
Breastfed as a baby	1.2	1.5	2.9	0.3	-0.8	-1.5	-1.7
Tense / ‘highly strung’	1.2	2.0	5.5	-0.4	1.5	-0.4	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	3.8	1.4	2.0	1.3	1.8
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	0.5	-0.9	0.3	-0.6
Birth weight of first child	0.5	0.9	1.7	0.3	-1.3	0.5	-1.3
Peak expiratory flow (PEF)	0.1	0.3	0.5	-0.4	0.6	-0.7	0.3
Pulse wave reflection index	0.4	0.5	1.3	0.1	-1.1	-0.7	-0.4
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.6	0.9	1.2	-0.4	0.9
Loud music exposure frequency	0.9	1.0	2.4	1.5	1.0	0.6	0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.7	1.6	0.7	-0.4	-0.1
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.9	-1.4	-1.2	-0.1	-0.7
Blood clot in the leg (DVT)	2.9	3.7	5.4	-0.7	2.3	-2.0	2.2
Medication: Paracetamol	0.3	0.4	0.8	0.0	-0.7	0.9	-0.7
Headache pain in last month	3.6	6.2	10.4	1.7	3.2	-2.8	2.0
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	6.5	1.1	2.0	-0.9	2.5
Glaucoma (self-reported)	0.3	0.4	1.0	-1.0	0.4	-0.2	0.6
Gout (self-reported)	0.3	0.4	0.9	0.9	-0.1	-0.9	0.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.6	-0.9	0.6	-2.1	0.2
Medication: Amlodipine	0.6	0.9	1.7	-0.3	1.3	-0.6	1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.6	-0.2	-0.9	1.3	0.1
Birth weight	0.8	1.7	2.9	-0.6	-1.7	1.3	-1.4
Chronic bronchitis/emphysema (mother)	1.6	1.8	3.1	-0.3	1.8	-1.4	1.4
High blood pressure (siblings)	0.4	0.6	1.3	-0.7	-1.1	0.7	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.7	2.0	-1.4	0.9	0.0	-0.1
Body fat percentage	0.6	2.2	5.2	-2.3	0.7	-1.7	-0.5
Leg fat percentage (right)	0.3	1.0	2.7	-1.6	0.3	-1.0	-0.5
Arm fat-free mass (right)	1.0	5.1	9.8	-3.1	-0.0	-3.1	-1.0
Exposure to tobacco smoke outside home	1.1	1.4	3.1	0.5	1.8	-0.8	1.3
Comparative body size at age 10	0.1	0.2	0.7	0.2	0.1	0.4	-0.8
Number of full brothers	0.5	0.6	2.1	0.3	-1.5	0.2	-0.3
Worry too long after embarrassment	0.5	0.9	1.8	0.8	1.0	-0.3	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	3.7	4.7	12.4	1.2	3.5	-1.0	2.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	-0.1	0.8	-1.0	0.1
Number of children fathered	2.3	2.6	4.2	-1.3	-1.8	2.0	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.8	-1.1	-1.4	2.0	-1.5
Age at first live birth	0.9	1.5	4.3	-0.2	-1.2	2.1	-0.6
Pulse wave peak to peak time	0.7	0.8	1.6	0.1	1.2	-1.3	-0.1
Health satisfaction	0.2	0.3	1.0	1.0	-0.2	0.3	0.0
Shortness of breath walking on level ground	0.5	0.6	1.7	1.3	-0.0	-0.0	0.8
Qualifications: College or University degree	0.0	0.1	0.5	0.1	0.7	-0.2	0.1
Eye problems/disorders: None of the above	0.6	0.7	1.1	-0.3	-1.0	0.7	-1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.2	-1.1	0.2	-0.1	-0.2
Emphysema/chronic bronchitis	0.2	0.3	0.8	0.9	-0.2	-0.2	-0.4
Medication for pain relief, constipation, heartburn	0.4	0.6	1.1	1.1	0.8	-0.1	0.9
Neck or shoulder pain in last month	3.2	4.5	7.0	-0.5	2.4	-2.2	2.7
Medication: Blood pressure	1.8	3.3	4.9	-1.0	-2.2	1.9	-1.9
Angina (self-reported)	1.9	2.5	4.5	-2.1	-1.3	0.3	-1.9
Migraine (self-reported)	0.3	0.3	1.0	0.4	-0.3	1.0	-0.5
Medication: Ibuprofen	0.2	0.2	0.8	-0.1	0.4	0.9	0.2
Medication: Allopurinol	0.0	0.1	0.1	0.1	0.2	-0.2	-0.3
Medication: Omeprazole	0.6	0.7	1.0	0.9	0.9	-1.0	0.4
Medication: Seretide 50 evohaler	1.9	2.2	6.0	1.0	2.5	0.2	1.3
Mean time to correctly identify matches	0.3	0.6	1.9	0.1	-0.2	0.6	-1.4
Heart disease (mother)	1.2	1.4	3.0	-1.1	-1.7	0.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.4	0.9	-1.5	1.2	-0.5
Whole body fat mass	0.9	3.7	8.0	-2.8	0.5	-2.3	-1.1
Leg fat mass (right)	0.7	2.5	6.0	-2.5	0.4	-1.8	-0.9
Arm predicted mass (right)	1.1	5.4	10.3	-3.2	0.1	-3.2	-1.0
Pulse rate, automated reading	0.4	1.3	2.7	1.0	1.6	-0.9	0.9
Alcohol intake frequency.	0.2	0.4	1.0	-1.0	0.5	-0.1	0.5
Comparative height size at age 10	0.5	2.6	4.4	-1.9	1.4	-2.1	-0.5
Number of full sisters	0.7	0.8	1.5	0.4	-0.8	-1.2	-1.0
Suffer from ‘nerves’	2.4	3.8	6.7	2.6	1.9	-0.3	2.1
Overall health rating	0.4	0.9	2.2	1.5	0.7	0.8	-0.3
Chest pain or discomfort	0.7	1.0	2.3	-1.5	1.2	-0.2	0.6
Had major operations	0.4	0.4	0.9	1.0	0.3	-0.8	0.2
Age at last live birth	0.9	1.3	2.2	-0.9	-1.4	1.5	-0.5
Family relationship satisfaction	4.4	5.4	8.5	0.8	2.5	-2.5	2.9
Leg pain on walking	0.3	0.4	1.1	1.1	-0.4	0.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	-0.1	-0.3	-0.2	-0.0
Commuting to job workplace: Car/motor vehicle	1.3	1.4	3.0	-1.7	-1.1	-0.3	-1.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	0.9	-0.7	-0.0	-0.2
Medication: Aspirin	0.6	0.8	2.6	-1.6	-0.0	-0.8	0.0
Supplements: Vitamin C	0.3	0.3	1.0	1.0	0.0	-0.1	0.5
Knee pain experienced in last month	0.0	0.0	0.1	0.3	0.1	-0.3	-0.1
Hypertension (Self-reported)	0.4	1.1	1.7	-0.9	-1.2	1.3	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	1.0	-0.9	0.5	0.1
Illnesses of father: Heart disease	0.7	1.0	1.4	-0.7	1.0	-1.2	1.1
Illnesses of siblings: Diabetes	0.4	0.5	1.1	-0.4	0.4	-0.8	1.1
Smoking status: Previous	1.8	2.7	7.6	-2.8	-0.9	-0.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	13.1	-0.2	1.7	-3.6	0.9
Whole body fat-free mass	1.0	5.7	11.0	-3.1	0.1	-3.3	-1.3
Leg fat-free mass (right)	0.9	4.9	9.5	-3.1	0.2	-3.0	-0.9
Arm fat percentage (left)	0.3	1.3	3.0	-1.7	0.2	-1.2	-0.7
Average weekly red wine intake	1.3	1.9	3.6	1.1	1.7	-0.4	1.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.9	0.9	-0.3	0.2	-0.4
Mood swings	1.4	2.6	6.4	-0.9	2.5	-0.3	1.7
Loneliness, isolation	0.9	1.2	3.5	-1.9	0.7	0.5	0.7
Long-standing illness, disability or infirmity	0.4	0.7	1.2	-0.4	1.1	-1.1	0.0
Ever had bowel cancer screening	1.8	2.1	3.9	1.9	-0.0	2.0	0.8
Diabetes diagnosed by doctor	2.3	3.8	7.4	-1.5	-2.2	0.6	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.0	-0.6	0.3	-0.7	-1.0
Friendships satisfaction	1.5	1.8	2.6	1.4	1.6	-0.7	1.6
Qualifications: nursing, teaching	1.0	1.6	2.5	-0.2	1.6	-1.2	1.5
Commuting to job workplace: Walk	0.4	0.5	1.4	1.2	0.7	0.1	0.2
Eye problems/disorders: Cataract	0.3	0.3	1.1	-1.1	0.5	-0.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.2	-1.1	1.1	-0.9	-0.6
Medication for cholesterol	0.0	0.1	0.2	-0.4	0.0	0.2	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.3	1.1	0.8	-0.6	-1.1
Back pain experienced in last month	1.4	2.0	4.4	-0.6	2.1	-1.7	0.8
Mineral and other dietary supplements	1.2	1.6	2.9	-1.0	-1.5	-0.4	-1.7
Breast cancer (self-reported)	1.3	1.5	2.0	1.4	1.0	-1.4	1.1
Asthma (self-reported)	0.3	0.7	2.1	0.4	1.5	-0.1	0.6
Osteoporosis (self-reported)	1.0	1.3	1.9	1.2	-1.4	1.2	0.1
Osteoarthritis (self-reported)	0.7	1.0	2.0	0.8	-0.5	1.4	-1.0
Medication: Aspirin	0.6	0.7	2.6	-1.6	-0.3	-0.0	-0.5
Medication: Gliclazide	2.7	3.0	4.8	-0.8	-1.9	2.2	-1.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	0.9	0.3	-0.1	0.3
Smoking status: Current	0.8	1.3	1.6	1.2	1.1	-1.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.2	-0.3	-0.3	1.8	-0.8
Whole body water mass	1.0	5.7	11.2	-3.1	0.1	-3.3	-1.3
Leg predicted mass (right)	1.0	5.1	9.9	-3.1	0.2	-3.0	-1.0
Arm fat mass (left)	0.7	3.0	6.8	-2.6	0.2	-1.9	-1.2
Number of self-reported non-cancer illnesses	0.3	0.6	1.2	0.5	1.1	-0.9	0.2
Average weekly champagne plus white wine intake	0.4	0.5	0.7	-0.8	0.8	0.5	-0.8
Miserableness	0.2	0.4	1.0	-0.1	1.0	0.3	0.6
Guilty feelings	0.8	1.3	2.5	0.2	1.5	-0.5	1.6
Wears glasses or contact lenses	0.1	0.1	0.5	-0.7	0.0	-0.1	0.1
Ever taken oral contraceptive pill	0.7	0.8	1.8	-1.3	-0.6	0.3	0.9
Hearing aid user	1.2	1.4	3.1	-0.5	1.3	-0.7	1.7
Mother’s age at death	0.7	0.9	2.6	0.2	-0.3	1.6	-1.0
Financial situation satisfaction	4.5	5.6	10.4	-0.2	3.2	-2.0	2.8
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.3	1.5	-0.1	0.5	-0.9
Commuting to job workplace: Public transport	0.8	0.9	2.5	1.6	0.4	0.4	-0.9
Eye problems/disorders: Glaucoma	1.9	2.2	2.9	-0.8	1.7	-1.7	1.6
Medication: Blood pressure	0.3	0.6	2.4	-1.5	0.1	0.1	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	0.1	-0.6	0.5	-1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.2	0.9	0.7	1.5	1.0
High cholesterol (Self-reported)	1.1	2.0	4.4	-1.3	-1.4	0.3	-2.1
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.4	-0.2	0.5	-0.1
Medication: Paracetamol	1.0	1.6	3.9	-0.2	-1.3	2.0	-0.9
Medication: Lisinopril	3.2	4.2	7.6	-1.4	-2.8	2.2	-1.4
Medication: Atorvastatin	1.7	2.1	3.6	0.6	-1.9	0.9	-1.8
Illnesses of father: High blood pressure	0.2	0.3	0.6	-0.4	-0.2	0.8	-0.6
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	-0.6	0.3	-0.3
Ever smoked	0.3	0.5	1.1	-0.7	-0.7	-0.4	-1.0
Basal metabolic rate	1.1	5.8	11.6	-3.2	0.3	-3.4	-1.2
Leg fat percentage (left)	0.3	1.2	3.5	-1.9	0.5	-1.0	-0.1
Arm fat-free mass (left)	1.2	5.9	11.4	-3.4	0.2	-3.3	-1.0
Number of operations (self-reported)	2.9	4.2	6.1	2.5	2.3	-2.0	1.2
Average weekly beer plus cider intake	0.1	0.1	0.3	0.5	0.3	0.1	-0.2
Irritability	0.5	0.8	1.1	-0.8	1.0	1.0	0.6
Risk taking	1.9	2.7	6.1	0.4	1.3	-2.5	1.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.7	0.5	-0.5	0.7	1.3
Fractured/broken bones in last 5 years	0.8	1.0	2.8	-0.3	0.8	-1.7	-0.5
Age started oral contraceptive pill	0.6	0.7	1.1	-0.9	0.6	0.7	1.1
Diastolic blood pressure, automated reading	0.3	1.0	3.6	0.5	0.0	1.9	-0.2
Ever depressed for a whole week	1.3	1.6	4.1	-1.0	-1.0	2.0	-0.6
Unable to work because of sickness or disability	1.8	2.3	5.2	0.4	-2.3	0.7	-1.9
Commuting to job workplace: Cycle	1.5	1.8	3.0	1.4	1.7	-1.3	0.6
Myopia	1.5	2.1	3.9	2.0	-0.9	1.1	-1.6
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.1	1.8	1.0	-0.9	0.5
Cholesterol lowering medication	2.0	2.9	5.3	-0.9	-2.3	0.3	-2.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.4	0.2	0.9	-1.2	1.0
Pain experienced in last month	1.7	2.9	5.9	1.7	-1.5	2.4	-0.6
Supplements: Calcium	3.9	4.3	5.6	2.2	1.9	-2.4	1.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	-0.5	0.9	-1.2	0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-1.1	0.4	-0.5	0.3
Deep venous thrombosis (DVT) (self-reported)	2.6	3.3	5.0	-1.0	2.2	-1.9	1.9
Heart disease (siblings)	0.7	0.9	2.0	-1.4	-1.1	-0.5	-0.5
Alcohol drinker status: Previous	0.5	0.5	1.7	-0.1	0.2	0.6	1.3
Pack years of smoking	1.3	1.9	5.4	-2.3	-1.5	0.0	-0.2
Impedance of whole body	0.5	2.4	4.7	1.0	2.2	-0.4	1.9
Leg fat mass (left)	0.7	2.8	6.9	-2.6	0.5	-1.9	-0.6
Arm predicted mass (left)	1.2	5.9	11.2	-3.4	0.1	-3.3	-1.1