TWAS hub - NEU3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.047	0.0200	1.2e-03	0.039	0.019	0.028	0.018	0.035	1.4e-05	0.0019	2.1e-04	0.0025	3.6e-05
2	GTEx	Muscle Skeletal	0.126	0.0404	1.7e-06	0.028	NA	0.066	NA	0.079	9.1e-04	NA	4.6e-07	NA	3.8e-08
3	GTEx	Ovary	0.498	0.1320	2.5e-03	0.106	NA	0.109	NA	0.146	1.4e-03	NA	1.3e-03	NA	2.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Ever had bowel cancer screening	5.0	5.9	7.0	-2.6	2.0	2.6
Birth weight of first child	4.8	8.8	15.2	3.9	-2.5	-2.2
Medication: Cholesterol lowering	4.0	6.2	7.8	1.9	-2.7	-2.8
Bipolar Disorder (2018)	3.7	5.8	9.2	-1.9	2.1	3.0
Diverticular disease/diverticulitis (self-reported)	3.6	4.2	8.0	-2.8	2.0	0.7
Qualifications: nursing, teaching	3.5	5.5	14.0	3.7	1.5	-0.7
Alcohol usually taken with meals	3.2	5.1	6.2	2.4	-2.5	-1.8
Chronic bronchitis/emphysema (father)	2.9	3.4	5.7	1.1	-1.9	-2.4
Sensitivity / hurt feelings	2.7	4.6	8.3	-2.9	-2.1	1.1
Unable to work because of sickness or disability	2.7	3.5	8.1	-1.4	-2.9	-0.6
Medication: Levothyroxine sodium	2.4	4.1	9.8	3.1	-0.3	-1.6
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	12.9	3.6	0.1	-1.1
Body Mass Index (BMI) (2010)	2.2	3.0	7.0	-2.6	-0.5	1.3
Prospective memory result	2.2	2.7	5.0	-2.2	0.7	1.6
Coronary Artery Disease (CAD)	2.1	2.5	6.5	1.0	-2.5	-0.3
LDL Cholesterol	2.1	3.4	4.4	1.8	-2.1	-1.6
Medication: Simvastatin	2.1	3.1	4.7	2.2	-0.9	-2.0
Crohns Disease (2012)	2.0	3.3	6.3	1.7	-2.5	-0.7
Type 2 Diabetes (T2D) (2018)	2.0	3.8	7.5	1.5	-1.3	-2.7
Pulse rate	2.0	3.3	8.5	-1.0	2.9	-0.5
Emphysema/chronic bronchitis	2.0	2.2	4.2	-2.0	0.1	1.6
Smoking status: Previous	2.0	3.1	5.6	2.4	-1.4	-1.2
Age started oral contraceptive pill	2.0	2.5	4.4	1.3	2.1	-1.2
Supplements: Calcium	2.0	2.2	3.8	1.6	2.0	-0.5
Crohns Disease (2017)	1.9	4.2	7.6	2.0	-2.8	-1.0
Ever had hysterectomy (womb removed)	1.9	2.1	2.7	1.6	-1.5	-1.2
Had other major operations	1.9	2.4	6.4	0.8	0.4	-2.5
Medication: Aspirin	1.9	2.5	7.1	0.6	-0.4	-2.7
Fractured/broken bones in last 5 years	1.9	2.4	6.2	2.5	0.4	-0.9
Hypothyroidism (self reported)	1.8	4.2	9.9	3.1	-0.1	-1.6
Systolic blood pressure, automated reading	1.8	5.2	14.3	-3.8	0.5	1.0
Father’s age at death	1.8	2.4	4.5	2.1	0.4	-1.7
Hair/balding pattern: Pattern 3	1.8	2.6	7.4	0.4	2.7	-0.5
Average weekly champagne plus white wine intake	1.8	2.5	5.8	2.4	-0.4	-1.3
Rheumatoid Arthritis	1.7	2.4	6.1	0.0	-1.0	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.9	-0.8	1.5	2.0
Medication: Seretide 50 evohaler	1.7	1.9	2.9	-1.7	1.6	0.5
High cholesterol (Self-reported)	1.7	3.0	4.7	2.2	-0.6	-2.0
Age at First Birth	1.6	2.3	3.7	1.9	1.7	-0.7
Primary Biliary Cirrhosis	1.6	2.3	4.5	-2.1	1.2	0.9
Leg fat-free mass (left)	1.6	8.7	21.9	4.7	-1.8	-1.0
Townsend deprivation index at recruitment	1.6	2.2	4.2	-2.0	1.3	0.9
Leg predicted mass (left)	1.6	8.4	21.1	4.6	-1.8	-0.9
Number of live births	1.6	2.2	5.4	2.3	-1.1	0.3
Medication: Lansoprazole	1.6	1.8	4.6	-2.1	0.8	-0.3
Standing height	1.6	15.6	44.4	6.7	0.5	-1.5
Chronic bronchitis/emphysema (mother)	1.6	1.9	5.2	0.7	2.3	0.2
Asthma (self-reported)	1.6	3.1	4.8	-2.2	-0.4	2.1
Medication: Aspirin	1.6	2.1	6.4	0.2	-0.1	-2.5
Systolic Blood Pressure	1.5	7.4	20.2	-4.5	1.1	0.9
Trunk fat-free mass	1.5	8.4	23.1	4.8	-1.4	-0.6
Trunk predicted mass	1.5	8.8	24.1	4.9	-1.4	-0.6
Loud music exposure frequency	1.5	1.6	4.0	-2.0	0.8	-0.5
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.2	-0.9	0.8	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	5.0	-2.2	-0.2	0.4
Leg fat-free mass (right)	1.5	8.0	19.9	4.5	-1.7	-1.1
Leg predicted mass (right)	1.5	8.0	19.7	4.4	-1.8	-1.1
Medication: Paracetamol	1.5	2.4	3.9	-2.0	-0.7	1.6
Medication: Atorvastatin	1.5	1.9	3.9	1.0	-2.0	-0.9
Alzheimer’s Disease (in father)	1.4	1.5	1.9	1.0	-1.2	-1.4
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.2	-0.9	1.3	1.5
Height	1.4	27.5	81.0	9.0	-0.8	-1.0
Age when periods started (menarche)	1.4	3.4	6.6	2.6	-0.2	-1.9
Hearing difficulty/problems with background noise	1.4	2.2	5.0	1.2	0.5	-2.2
Pulse wave peak to peak time	1.4	1.6	3.9	0.9	-0.4	-2.0
Comparative height size at age 10	1.4	8.0	19.9	4.5	0.9	-1.8
Commuting to job workplace: Car/motor vehicle	1.4	1.5	1.8	1.1	-1.3	1.3
Whole body fat-free mass	1.4	7.7	20.5	4.5	-1.5	-0.7
Diabetes diagnosed by doctor	1.4	2.4	3.4	0.7	-1.8	-1.8
Back pain experienced in last month	1.4	2.0	3.7	-0.3	1.9	-1.5
Whole body water mass	1.4	7.8	20.6	4.5	-1.5	-0.7
Basal metabolic rate	1.4	7.7	19.9	4.5	-1.6	-0.9
Diastolic blood pressure, automated reading	1.4	4.2	9.7	-3.1	1.2	1.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.7	2.8	1.7	1.5	0.5
Schizophrenia vs Biploar Disorder	1.3	1.7	4.1	-0.9	-0.6	-2.0
HDL Cholesterol	1.3	2.1	3.9	2.0	0.3	-1.5
Relative age of first facial hair	1.3	2.6	7.9	-0.0	2.8	-0.0
Medication: Metformin	1.3	1.9	3.9	1.1	-2.0	-0.7
Past tobacco smoking	1.3	2.3	4.0	-2.0	0.7	1.6
Weight	1.3	6.2	14.7	3.8	-1.6	-1.2
Asthma	1.3	2.6	4.7	-2.2	-0.3	1.8
Pulse wave reflection index	1.3	1.6	3.0	0.9	-1.1	1.7
Neck or shoulder pain in last month	1.3	1.8	2.9	-1.2	1.7	-1.0
Chest pain or discomfort	1.3	1.9	5.5	-2.3	-0.4	-0.1
Leg pain on walking	1.3	1.7	3.1	-1.8	-0.7	1.2
Illnesses of father: Heart disease	1.3	1.9	3.7	-1.9	1.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	8.3	2.9	-0.2	0.2
Hearing aid user	1.3	1.5	2.6	0.9	0.9	-1.6
Hearing difficulty/problems: Yes	1.2	1.8	3.4	1.8	-0.2	-1.4
Diabetes (father)	1.2	1.5	3.6	0.2	-1.9	-0.9
Medication: Atenolol	1.2	1.5	2.1	-0.8	-1.5	1.3
Diabetes (self-reported)	1.2	1.9	2.8	0.6	-1.7	-1.6
Hip circumference	1.2	5.1	12.2	3.5	-1.4	-1.0
Time employed in main current job	1.2	1.4	2.9	-1.7	0.7	0.9
Glaucoma (self-reported)	1.2	1.4	3.7	-1.9	-0.0	0.6
Medication: Ventolin 100micrograms inhaler	1.2	1.5	1.9	-1.4	-1.1	1.2
Medication: Allopurinol	1.2	1.6	3.7	-1.9	1.0	-0.2
Friendships satisfaction	1.2	1.5	4.2	-0.5	-0.0	-2.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.1	-0.5	-1.4	-1.4
Cholesterol lowering medication	1.2	1.7	3.2	1.8	-1.3	-0.6
Depression (Nagel 2018)	1.1	1.7	4.1	-2.0	0.9	0.3
Verbal and Numeric Reasoning (VNR)	1.1	2.6	3.8	2.0	0.6	-1.9
Bipolar Disorder (2011)	1.1	1.0	2.2	-0.5	0.8	1.5
Respiratory disease	1.1	2.4	3.7	-1.9	0.2	1.9
Qualifications: None of the above	1.1	2.4	4.2	-2.0	0.8	1.5
Blood clot in the leg (DVT)	1.1	1.4	2.3	1.5	1.3	0.4
Birth weight	1.1	2.4	5.6	2.4	-1.0	-0.9
Number of full sisters	1.1	1.4	2.4	0.1	-1.3	-1.5
Average weekly red wine intake	1.1	1.6	4.2	0.3	0.7	-2.0
Osteoporosis (self-reported)	1.1	1.3	2.1	1.4	-1.4	-0.3
Guilty feelings	1.1	1.6	3.3	-1.8	0.3	1.2
Irritability	1.1	1.8	4.9	-2.2	-0.4	0.5
Risk taking	1.1	1.6	4.2	2.0	0.5	-0.6
Prostate Cancer	1.0	1.5	3.7	0.6	0.5	-1.9
Stomach or abdominal pain in last month	1.0	1.2	3.3	-1.8	-0.2	-0.5
Impedance of leg (left)	1.0	4.6	8.0	-2.4	2.8	0.2
Pulse wave Arterial Stiffness index	1.0	1.1	3.1	-0.4	0.3	1.8
Medication: Paracetamol	1.0	1.7	3.9	-2.0	-0.6	1.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.5	-0.4	1.6	1.6
Heart disease (mother)	1.0	1.3	2.3	-0.4	-1.2	1.5
Family relationship satisfaction	1.0	1.2	3.2	0.7	0.3	-1.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	2.5	1.6	-0.1	-1.4
Medication: Blood pressure	1.0	1.8	3.7	-0.8	1.1	1.9
Arm fat-free mass (left)	1.0	5.2	14.1	3.8	-1.1	-0.6
Arm predicted mass (left)	1.0	5.3	13.8	3.7	-1.3	-0.5
Intelligence (Savage-Jansen 2018)	0.9	2.7	6.9	2.6	-0.3	-1.1
Medication for hormone replacement therapy	0.9	1.0	2.8	0.2	1.7	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	4.3	-2.1	-0.0	1.3
Sitting height	0.9	6.1	18.1	4.2	-0.3	-0.2
Trunk fat mass	0.9	4.0	9.1	3.0	-1.2	-1.2
Falls in the last year	0.9	1.2	1.8	0.9	1.4	-1.1
Noisy workplace	0.9	1.1	2.7	-0.8	1.6	-0.2
Arm fat-free mass (right)	0.9	4.4	11.9	3.5	-1.2	-0.3
Medication for pain relief, constipation, heartburn	0.9	1.6	3.6	0.7	0.8	1.9
Arm predicted mass (right)	0.9	4.5	12.1	3.5	-1.1	-0.3
Major Depression (MDD)	0.8	1.0	1.5	-0.7	1.0	1.2
Severe depression (siblings)	0.8	0.9	1.5	1.2	0.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.0	-1.7	-0.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.0	-1.4	0.0	-1.3
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.9	1.4	-0.5	-0.8
Headache pain in last month	0.8	1.3	3.1	-0.3	1.8	0.8
Gout (self-reported)	0.8	1.1	2.3	-1.5	0.5	-0.9
Number of children fathered	0.8	0.9	2.5	-0.3	0.0	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.0	-1.4	-0.6	-0.7
Long-standing illness, disability or infirmity	0.8	1.3	3.3	-0.4	0.5	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.0	1.4	-0.3	-0.7
Commuting to job workplace: Public transport	0.8	1.0	1.8	-0.9	0.5	-1.4
Ulcerative Colitis	0.7	1.1	3.0	-1.7	0.3	0.4
Heel T-Score	0.7	5.5	10.4	-3.2	1.0	2.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.6	-0.7	1.3	-0.9
Impedance of leg (right)	0.7	3.6	6.5	-2.0	2.5	0.4
Supplements: Glucosamine	0.7	0.9	1.3	1.1	1.1	0.3
Had menopause	0.7	0.9	2.3	-0.2	1.5	-0.5
Neuroticism score	0.7	1.4	3.4	-1.8	-0.9	0.3
Length of working week for main job	0.7	0.8	1.3	0.4	1.2	-1.0
Exposure to tobacco smoke at home	0.7	0.8	1.7	0.7	1.3	-0.5
Whole body fat mass	0.7	2.9	6.0	2.5	-1.4	-0.9
Pulse rate, automated reading	0.7	2.2	3.7	0.4	1.9	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.4	0.5	-0.8	-1.2
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.7	1.0	-0.1	-1.3
Arm fat mass (left)	0.7	3.0	5.4	2.3	-1.7	-0.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.0	1.4	-0.3	-0.6
Depressed Affect (Nagel 2018)	0.6	1.2	3.2	-1.8	0.6	-0.1
Neuroticism (Nagel 2018)	0.6	1.5	4.2	-2.0	0.1	0.6
Triglycerides	0.6	0.9	1.8	-0.6	-0.7	1.3
BMI	0.6	3.5	10.0	0.0	-3.2	-0.6
Chronotype (morning person)	0.6	1.4	4.0	0.2	-2.0	-0.4
Average weekly spirits intake	0.6	0.7	1.3	-0.9	1.1	0.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.2	-1.5	0.3	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.6	0.5	-0.7	-1.3
Current tobacco smoking	0.6	1.0	1.6	-1.0	1.3	0.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	-0.6	1.2	-0.2
High blood pressure	0.6	1.6	2.9	-1.4	-0.1	1.7
High blood pressure (mother)	0.6	0.8	2.0	-0.2	-0.7	1.4
Pain all over the body in last month	0.6	0.6	1.7	-0.2	-0.2	-1.3
Fluid intelligence score	0.6	1.3	2.3	1.5	0.5	-1.2
Alcohol intake versus 10 years previously	0.6	0.9	2.6	-0.4	1.6	-0.3
Mouth/teeth dental problems: Dentures	0.6	1.1	1.6	-0.8	1.2	1.0
Arm fat mass (right)	0.6	2.6	4.3	2.1	-1.7	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.2	-1.5	0.8	0.4
Medication: Amlodipine	0.6	0.9	1.6	-0.4	1.0	-1.3
Number of full brothers	0.6	0.7	1.9	-0.2	-1.4	-0.4
Medication: Blood pressure	0.6	1.0	1.5	-0.8	-1.2	-0.9
Age at last live birth	0.6	0.9	2.2	0.6	-0.4	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.1	-1.0	1.0	-0.5
Medication: Gliclazide	0.6	0.7	1.6	-0.6	-1.3	-0.4
Mother’s age at death	0.6	0.8	1.6	-0.6	-0.5	1.3
Financial situation satisfaction	0.6	0.7	1.7	-0.5	1.3	-0.4
Medication: Lisinopril	0.6	0.8	1.6	-0.7	-0.5	1.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	-0.6	1.2	-0.7
Reaction Time	0.5	0.9	2.0	-1.4	0.4	0.8
Blood White Count	0.5	3.4	4.7	-2.2	-1.4	1.9
Waist Hip Ratio (WHR)	0.5	2.1	5.4	-2.3	0.5	-0.8
Allergy or Eczema	0.5	1.3	2.4	1.5	1.0	-0.8
Lung FEV1/FVC ratio	0.5	2.7	5.8	2.4	-1.5	-0.3
Angina	0.5	0.6	0.9	-0.3	-1.0	-0.9
Diabetes (mother)	0.5	0.7	1.7	0.4	1.3	0.4
Pack years adult smoking proportion	0.5	0.7	1.5	0.3	-1.2	-0.7
Average weekly fortified wine intake	0.5	0.6	0.9	-0.5	-0.9	-1.0
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.1	1.5	0.1	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.1	-1.4	-0.8	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.5	1.2	0.6	-0.1
Illnesses of mother	0.5	0.6	1.6	-0.2	-0.3	-1.3
Breastfed as a baby	0.5	0.6	1.8	1.3	-0.1	-0.2
Hair/balding pattern: Pattern 4	0.5	1.1	1.9	0.9	-1.4	-0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.7	1.3	0.2	-0.4
Exposure to tobacco smoke outside home	0.5	0.6	1.0	0.6	0.7	-1.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.6	-1.6	0.4	0.0
Health satisfaction	0.5	0.7	1.3	-0.9	-0.1	1.1
Qualifications: College or University degree	0.5	1.7	4.1	2.0	0.9	-0.1
Angina (self-reported)	0.5	0.6	1.2	-0.4	-1.1	-0.8
Mean time to correctly identify matches	0.5	0.9	2.6	-1.6	0.1	0.1
Suffer from ‘nerves’	0.5	0.8	2.1	-1.4	0.6	-0.2
Had major operations	0.5	0.5	1.3	0.4	-1.1	-0.5
Knee pain experienced in last month	0.5	0.8	2.3	1.5	0.1	-0.1
Hypertension (Self-reported)	0.5	1.4	2.2	-1.4	-0.2	1.5
Medication for cholesterol	0.5	0.7	1.7	0.4	-1.3	-0.6
Mineral and other dietary supplements	0.5	0.7	1.1	-0.0	-1.1	-1.0
Smoking status: Current	0.5	0.7	1.7	-0.7	1.3	0.0
Medication: Bendroflumethiazide	0.5	0.8	1.2	-1.1	0.5	0.9
Ever smoked	0.5	0.8	1.6	0.9	0.2	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.8	-0.1	1.3	-0.4
Heart disease (siblings)	0.5	0.6	0.9	-0.4	-0.9	0.9
Schizophrenia (2018)	0.4	0.9	1.2	0.5	-1.1	-1.1
Irritable Bowel Disease (IBD)	0.4	0.8	2.3	0.4	-1.5	-0.0
Ulcerative Colitis (UC)	0.4	0.7	1.6	-1.3	0.3	0.7
Mean Putamen Volume	0.4	0.5	0.8	0.9	-0.8	-0.2
Fasting Glucose	0.4	0.5	1.1	0.5	1.1	-0.3
HbA1C	0.4	0.5	1.2	1.1	0.4	-0.1
Blood Red Count	0.4	3.5	8.9	-3.0	-0.6	1.1
Neuroticism	0.4	0.9	1.5	-1.2	-0.4	1.1
Number of treatments/medications taken	0.4	0.7	1.3	-1.1	-0.6	-0.6
Trunk fat percentage	0.4	1.7	3.0	1.7	-1.0	-1.1
Taking other prescription medications	0.4	0.5	1.4	-0.5	-0.1	-1.2
Body mass index (BMI)	0.4	1.5	3.5	0.9	-1.9	-0.4
Waist circumference	0.4	1.5	2.5	1.6	-1.1	-0.9
Nervous feelings	0.4	0.7	1.9	-1.4	0.3	-0.2
Medication: Ramipril	0.4	0.5	1.1	-0.2	-1.1	-0.5
Arm fat percentage (right)	0.4	1.4	2.2	1.1	-1.5	-0.9
Worrier / anxious feelings	0.4	0.7	1.3	-0.7	-1.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.9	-1.4	-0.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.3	1.8	-0.6	-0.1
Tense / ‘highly strung’	0.4	0.7	1.7	-1.3	0.6	-0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.1	0.7	-1.0	0.0
Forced vital capacity (FVC), Best measure	0.4	1.4	4.3	2.1	-0.1	0.1
Worry too long after embarrassment	0.4	0.7	1.2	-1.1	-0.8	0.6
Shortness of breath walking on level ground	0.4	0.5	0.9	-0.9	-0.5	0.6
Migraine (self-reported)	0.4	0.4	1.0	-0.6	1.0	0.1
Medication: Omeprazole	0.4	0.5	1.2	-0.5	1.1	-0.3
Leg fat mass (right)	0.4	1.5	3.2	1.8	-1.1	-0.5
Illnesses of siblings: Diabetes	0.4	0.4	0.7	0.5	0.8	-0.6
Arm fat percentage (left)	0.4	1.5	2.6	1.1	-1.6	-0.9
Mood swings	0.4	0.7	1.0	-0.8	0.6	-1.0
Loneliness, isolation	0.4	0.5	1.2	-0.5	0.3	-1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-0.4	0.5	1.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.3	-1.1	0.8	-0.4
Eye problems/disorders: Glaucoma	0.4	0.4	0.8	-0.9	0.6	0.2
Number of operations (self-reported)	0.4	0.6	0.9	0.1	0.9	-0.9
Pain experienced in last month	0.4	0.6	0.8	-0.5	-0.9	0.9
Pack years of smoking	0.4	0.7	1.3	0.2	-1.1	-0.8
Impedance of whole body	0.4	2.1	5.0	-1.1	2.2	-0.2
Leg fat mass (left)	0.4	1.6	3.0	1.7	-1.2	-0.7
Bipolar Disorder or Schizophrenia	0.3	0.6	1.1	-0.8	0.5	1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	0.5	-1.0	-0.4
Ovarian Cancer	0.3	0.3	0.9	-1.0	-0.1	-0.3
Vitamin and mineral supplements	0.3	0.4	0.8	0.1	-0.9	0.6
Hand grip strength (right)	0.3	0.9	2.5	1.6	-0.4	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	0.4	-0.1	-0.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	0.5	0.6	0.7
Forced vital capacity (FVC)	0.3	1.0	2.9	1.7	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	2.5	1.6	-1.0	0.0
Happiness	0.3	0.4	1.2	-0.0	-0.2	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.6	1.3	0.6	0.1
Peak expiratory flow (PEF)	0.3	0.7	2.0	1.4	-0.1	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	1.1	-0.3	-0.0
High blood pressure (siblings)	0.3	0.4	0.7	-0.7	-0.8	-0.2
Body fat percentage	0.3	1.0	1.4	1.2	-1.0	-0.8
Age at first live birth	0.3	0.6	1.5	-0.0	0.4	-1.2
Overall health rating	0.3	0.6	1.2	-1.1	0.5	-0.7
Supplements: Vitamin C	0.3	0.4	0.8	0.9	0.6	0.0
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.7	-0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.5	0.5	-0.6	0.7	0.7
Alcohol drinker status: Never	0.3	0.3	0.4	-0.7	-0.5	0.6
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.8	0.6	0.1
Commuting to job workplace: Cycle	0.3	0.4	0.5	0.7	0.3	0.7
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.7	1.3	0.4	-0.9
Breast Cancer	0.2	0.5	1.5	-0.0	1.2	-0.3
Schizophrenia (2014)	0.2	0.5	1.5	-1.2	0.2	0.4
Smoking Status	0.2	0.5	0.7	0.9	-0.6	-0.5
Tanning	0.2	1.9	5.0	-0.4	-2.2	0.7
Hand grip strength (left)	0.2	0.5	0.6	0.5	-0.8	0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.4	0.3	-0.6	-0.6
Medication: Co-codamol	0.2	0.3	0.7	-0.0	0.4	-0.8
Maternal smoking around birth	0.2	0.4	0.8	-0.3	-0.9	0.4
Multivitamins +/- minerals	0.2	0.2	0.5	0.1	0.5	-0.7
Number of incorrect matches in round	0.2	0.3	0.8	-0.9	0.3	0.2
Financial difficulties in last 2 years	0.2	0.3	0.7	0.8	0.5	-0.1
Mouth/teeth dental problems	0.2	0.2	0.6	0.3	-0.8	0.3
Heart attack	0.2	0.3	0.6	-0.5	-0.2	0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.3	0.5	-0.6
Impedance of arm (right)	0.2	1.1	2.6	0.4	1.6	-0.8
Impedance of arm (left)	0.2	0.8	1.5	0.5	1.2	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.1	0.3	0.8
Eye problems/disorders: None of the above	0.2	0.3	0.7	0.2	-0.3	-0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.0	-0.3	0.8
Breast cancer (self-reported)	0.2	0.3	0.7	0.3	0.1	-0.8
Osteoarthritis (self-reported)	0.2	0.3	0.7	0.1	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.6	-0.7	-0.8	-0.2
Miserableness	0.2	0.3	0.9	-1.0	0.1	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.2	-0.0	0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	-0.8	0.1	0.6
Worry (Nagel 2018)	0.1	0.2	0.3	-0.6	0.5	0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	0.6	0.1	0.2
Neuroticism (2016)	0.1	0.2	0.3	-0.4	-0.6	0.3
Blood Platelet Count	0.1	0.8	1.9	-0.4	-1.4	0.5
Cardiovascular Disease	0.1	0.4	0.7	-0.8	-0.7	-0.2
Lung FVC	0.1	0.6	1.0	-1.0	0.6	0.7
Hair Pigment	0.1	3.6	6.5	2.5	1.0	-1.8
Supplements: Zinc	0.1	0.1	0.2	0.5	-0.4	0.1
Fed-up feelings	0.1	0.1	0.2	-0.5	-0.2	-0.3
Relative age voice broke	0.1	0.2	0.2	0.5	0.2	-0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.4	-0.0	0.2	-0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.1	-0.3	-0.6
Illnesses of siblings	0.1	0.2	0.6	0.1	0.8	-0.1
Depression (self-reported)	0.1	0.1	0.3	0.1	-0.0	-0.6
Lung cancer (father)	0.1	0.1	0.3	0.1	0.6	-0.4
Leg fat percentage (right)	0.1	0.3	0.7	0.4	-0.8	-0.2
Comparative body size at age 10	0.1	0.2	0.3	0.5	-0.5	0.5
Alcohol intake frequency.	0.1	0.3	0.5	0.6	0.7	0.0
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.2	0.0	-0.5
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.3	-0.5	0.3
Wears glasses or contact lenses	0.1	0.1	0.2	0.4	0.5	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.5	0.3	-0.1
Leg fat percentage (left)	0.1	0.3	0.7	0.4	-0.8	-0.5
Ever depressed for a whole week	0.1	0.1	0.3	-0.1	-0.3	0.5
Myopia	0.1	0.2	0.4	-0.2	0.6	0.0
Alcohol drinker status: Previous	0.1	0.2	0.4	0.2	0.7	-0.2
Lupus	0.0	0.1	0.1	-0.3	0.1	0.3
Blood Eosinophil Count	0.0	0.2	0.7	0.1	-0.8	-0.0
Allergy	0.0	0.1	0.3	-0.6	0.0	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.2	0.1	-0.3
Medication: Ibuprofen	0.0	0.1	0.1	-0.1	0.1	0.4

Hub : Genes

NEU3

Models

Trait associations