Hub : Genes

RNF169

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.071 0.0280 6.2e-04 0.035 0.030 0.026 0.031 0.031 3.4e-05 1.3e-04 3.8e-04 1.1e-04 1.1e-04
2 YFS Blood 0.027 0.0086 1.9e-07 0.016 0.024 0.034 0.027 0.033 4.7e-06 2.3e-08 3.0e-11 3.1e-09 4.9e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.0 3.1 3.5 -1.9 1.6
Bipolar Disorder or Schizophrenia 0.5 1.1 2.2 -1.5 0.2
Depressed Affect (Nagel 2018) 2.0 4.3 8.5 0.3 2.9
Depression (Nagel 2018) 3.3 5.0 10.0 0.2 3.2
Intelligence (Savage-Jansen 2018) 0.8 2.6 2.7 1.6 -1.6
Neuroticism (Nagel 2018) 1.1 2.7 5.2 0.3 2.3
Schizophrenia (2018) 0.3 0.7 1.2 -0.4 -1.1
Schizophrenia vs Biploar Disorder 0.1 0.1 0.1 -0.3 0.4
Worry (Nagel 2018) 0.5 1.1 2.3 -0.1 1.5
Alzheimer’s Disease (in mother) 0.8 0.9 1.2 0.8 1.1
Alzheimer’s Disease (in father) 1.3 1.4 2.2 -0.8 -1.5
Alzheimer’s Disease (including proxy) 0.0 0.0 0.0 0.0 -0.1
Crohns Disease (2017) 3.1 6.8 13.4 0.4 -3.7
Irritable Bowel Disease (IBD) 0.8 1.9 3.6 -0.4 -1.9
Ulcerative Colitis (UC) 0.2 0.4 0.5 -0.6 0.7
Major Depression (MDD) 0.4 0.4 0.7 0.4 0.8
Reaction Time 0.7 1.4 1.6 -1.3 1.0
Verbal and Numeric Reasoning (VNR) 0.4 1.0 1.2 1.1 -0.9
Breast Cancer 0.4 0.9 1.3 0.7 1.1
Ovarian Cancer 0.3 0.4 0.6 -0.8 0.3
Prostate Cancer 0.1 0.2 0.4 -0.6 0.2
Age at First Birth 0.0 0.0 0.1 0.0 -0.3
Bipolar Disorder (2011) 0.8 0.8 1.6 -0.2 1.3
Body Mass Index (BMI) (2010) 4.2 5.8 11.6 -3.4 0.1
Coronary Artery Disease (CAD) 1.9 2.2 4.3 0.4 -2.1
Crohns Disease (2012) 3.8 6.1 10.7 1.3 -3.3
Mean Putamen Volume 1.4 1.6 2.8 -0.6 -1.7
Fasting Glucose 0.0 0.0 0.1 -0.0 -0.3
HbA1C 0.6 0.7 1.4 1.2 0.3
HDL Cholesterol 0.6 1.0 1.7 1.3 0.5
LDL Cholesterol 3.2 5.1 9.4 -0.9 -3.1
Lupus 0.6 1.0 1.6 1.3 0.6
Neuroticism (2016) 0.1 0.2 0.3 0.2 0.6
Primary Biliary Cirrhosis 1.3 1.9 2.9 -1.7 0.9
Rheumatoid Arthritis 0.2 0.3 0.3 0.6 -0.4
Schizophrenia (2014) 0.5 1.0 1.7 -1.3 0.6
Triglycerides 1.1 1.8 2.2 -1.5 -1.2
Type 2 Diabetes (T2D) (2012) 1.3 1.5 2.8 -0.6 1.7
Ulcerative Colitis 0.2 0.3 0.6 0.0 0.7
Blood Eosinophil Count 0.0 0.2 0.4 0.1 0.6
Blood Platelet Count 0.1 0.7 1.4 -1.2 -0.3
Blood Red Count 0.2 1.5 2.7 -1.6 0.6
Blood White Count 0.3 2.0 4.0 -2.0 0.2
Heel T-Score 1.1 8.6 11.5 -3.4 2.4
BMI 0.6 3.5 6.4 -0.8 -2.5
Height 2.2 42.7 61.5 7.8 -4.9
Waist Hip Ratio (WHR) 0.5 2.4 4.4 -2.1 0.7
Systolic Blood Pressure 1.6 8.0 11.0 -3.3 2.2
Smoking Status 0.3 0.8 1.5 0.1 -1.2
Allergy or Eczema 0.3 0.9 1.5 1.2 0.5
Cardiovascular Disease 0.7 2.4 4.8 -2.2 -0.2
Hypothyroidism (self reported) 2.6 6.1 11.8 3.4 -0.6
Respiratory disease 0.8 1.8 2.5 -1.1 1.6
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.9 0.3 -1.7
Lung FEV1/FVC ratio 0.7 3.6 6.1 1.1 -2.5
Lung FVC 0.3 1.6 3.0 -1.7 0.5
Neuroticism 0.9 2.2 4.1 0.7 2.0
Chronotype (morning person) 1.6 3.6 6.2 -1.0 -2.5
Hair Pigment 0.1 4.0 6.6 2.6 -1.2
Tanning 0.2 2.8 3.8 -1.9 -1.4
Hand grip strength (left) 0.8 2.2 4.2 -0.5 -2.0
Number of treatments/medications taken 0.1 0.2 0.4 -0.7 -0.0
Average weekly spirits intake 0.7 0.9 1.8 0.1 1.4
Sensitivity / hurt feelings 0.2 0.4 0.7 -0.9 0.1
Frequency of depressed mood in last 2 weeks 1.4 2.0 4.0 0.2 2.0
Hearing difficulty/problems: Yes 0.5 0.8 1.5 1.2 -0.2
Relative age of first facial hair 1.3 2.7 5.3 0.5 2.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.8 0.9 -0.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.5 0.0 0.7
Ever had hysterectomy (womb removed) 1.3 1.5 2.1 0.9 -1.5
Systolic blood pressure, automated reading 2.0 5.8 11.2 -3.4 0.7
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 0.8 -0.8 -0.9
Angina 0.6 0.8 1.3 -0.6 -1.1
Medication for hormone replacement therapy 0.9 1.0 2.0 0.0 1.4
Vitamin and mineral supplements 0.8 1.1 2.1 0.2 -1.4
Supplements: Zinc 0.0 0.0 0.0 0.0 -0.1
Medication: Co-codamol 0.2 0.2 0.5 -0.7 -0.0
Medication: Metformin 1.5 2.1 3.9 -0.5 -2.0
Diabetes (father) 1.0 1.2 1.4 1.0 -1.2
Diabetes (mother) 0.4 0.5 0.5 0.7 0.7
Severe depression (siblings) 0.9 1.0 1.4 1.2 0.8
Pack years adult smoking proportion 0.6 1.0 1.9 0.1 -1.4
Impedance of leg (right) 1.3 6.1 8.0 -2.0 2.8
Leg fat-free mass (left) 3.0 15.8 19.8 4.5 -3.4
Trunk fat percentage 0.5 2.2 3.7 0.8 -1.9
Hand grip strength (right) 0.7 1.8 3.5 0.2 -1.9
Townsend deprivation index at recruitment 1.7 2.3 2.6 -1.6 1.4
Current tobacco smoking 0.3 0.6 1.1 -0.1 1.1
Average weekly fortified wine intake 0.0 0.0 0.1 0.3 0.2
Maternal smoking around birth 0.3 0.5 0.9 0.1 -1.0
Fed-up feelings 1.6 2.8 4.6 1.0 2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.3 3.1 5.9 0.6 2.4
Relative age voice broke 0.2 0.3 0.5 -0.7 -0.2
Taking other prescription medications 0.1 0.2 0.2 -0.3 0.5
Age when periods started (menarche) 0.4 0.9 1.6 1.3 -0.4
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 0.5 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.1 7.5 -2.7 0.8
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.4 0.5 1.8
Qualifications: CSEs or equivalent 0.0 0.0 0.0 -0.1 0.1
Serious illness, injury or assault to yourself 0.0 0.0 0.1 0.3 0.0
High blood pressure 0.4 1.1 2.2 -1.5 0.1
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.4 0.6 0.5
Multivitamins +/- minerals 0.7 0.8 1.5 0.4 1.2
Stomach or abdominal pain in last month 1.2 1.4 1.7 -1.3 1.1
Supplements: Glucosamine 2.1 2.8 3.6 1.9 1.4
Diverticular disease/diverticulitis (self-reported) 5.1 6.1 8.8 -1.8 3.0
Medication: Atenolol 1.3 1.6 1.9 -1.1 -1.4
Medication: Levothyroxine sodium 3.5 5.9 9.0 3.0 -1.7
Sitting height 1.4 10.1 16.0 4.0 -2.0
Chronic bronchitis/emphysema (father) 4.7 5.5 9.6 -1.2 -3.1
High blood pressure (mother) 0.2 0.2 0.4 -0.3 -0.6
Body mass index (BMI) 0.7 2.9 5.7 0.0 -2.4
Impedance of leg (left) 1.3 6.2 7.6 -2.2 2.8
Leg predicted mass (left) 2.9 15.2 18.9 4.3 -3.4
Trunk fat mass 1.3 5.5 7.1 1.9 -2.7
Waist circumference 0.5 1.9 3.5 0.5 -1.9
Number of incorrect matches in round 0.0 0.1 0.1 -0.3 0.2
Past tobacco smoking 1.2 2.2 3.7 -0.9 1.9
Alcohol usually taken with meals 3.7 6.0 7.3 2.7 -2.2
Nervous feelings 0.7 1.3 1.8 -0.9 1.3
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 4.7 0.0 2.2
Hearing difficulty/problems with background noise 0.2 0.3 0.5 0.2 0.7
Hair/balding pattern: Pattern 2 0.3 0.4 0.6 0.3 -0.8
Had menopause 0.3 0.3 0.5 -0.5 0.7
Had other major operations 2.1 2.6 2.6 1.6 1.6
Forced vital capacity (FVC) 0.4 1.5 3.1 1.8 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 3.9 -2.0 0.2
Ever unenthusiastic/disinterested for a whole week 2.2 2.7 5.4 2.3 0.1
Qualifications: None of the above 0.2 0.4 0.5 -0.6 0.7
Financial difficulties in last 2 years 0.1 0.1 0.1 -0.1 0.4
Mouth/teeth dental problems 0.1 0.1 0.2 -0.2 -0.5
Heart attack 0.3 0.3 0.3 -0.6 -0.6
Allergy 0.2 0.5 1.0 -0.3 -1.0
Pain all over the body in last month 0.1 0.1 0.1 -0.2 -0.3
Diabetes (self-reported) 1.2 1.9 3.5 -0.5 -1.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.1 -1.0 0.5
Medication: Ramipril 0.2 0.3 0.6 -0.8 -0.2
Medication: Simvastatin 2.5 3.7 7.2 -0.5 -2.7
Fluid intelligence score 0.4 0.7 1.3 1.1 -0.4
Illnesses of siblings 0.1 0.2 0.3 0.2 0.6
Neuroticism score 1.0 2.1 4.0 0.4 2.0
Weight 2.0 10.1 10.4 3.1 -3.2
Impedance of arm (right) 0.5 2.4 4.3 0.8 2.1
Arm fat percentage (right) 0.4 1.5 2.9 0.2 -1.7
Trunk fat-free mass 2.4 13.9 16.1 4.0 -3.4
Hip circumference 1.6 6.7 7.4 2.7 -2.5
Time employed in main current job 1.9 2.1 2.9 -1.7 1.2
Alcohol intake versus 10 years previously 0.2 0.3 0.4 -0.7 0.5
Father’s age at death 1.4 1.9 2.2 1.5 -1.2
Worrier / anxious feelings 0.2 0.4 0.5 -0.6 0.7
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 4.8 -0.1 2.2
Falls in the last year 0.9 1.3 2.0 1.4 0.7
Hair/balding pattern: Pattern 3 0.6 0.9 1.6 -0.5 1.3
Number of live births 1.4 2.0 3.8 0.3 -1.9
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.2 1.5 -0.7
Pulse rate 2.8 4.8 6.2 -1.8 2.5
Happiness 2.2 2.6 4.0 2.0 1.1
Noisy workplace 0.5 0.6 1.1 -0.4 1.0
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.1 1.5 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.3 -0.0 -0.6
Mouth/teeth dental problems: Dentures 0.8 1.4 2.0 -1.4 0.9
Asthma 0.8 1.5 2.0 -1.0 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.5 -0.0 0.7
Medication: Cholesterol lowering 2.7 4.2 8.2 -0.4 -2.9
Depression (self-reported) 0.6 0.7 1.1 0.5 1.1
Medication: Lansoprazole 2.3 2.6 5.2 -0.3 2.3
Prospective memory result 1.3 1.6 2.3 -1.5 1.0
Lung cancer (father) 0.3 0.3 0.3 -0.6 0.5
Illnesses of mother 0.0 0.0 0.0 0.0 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 2.9 1.7 -1.0
Pulse wave Arterial Stiffness index 0.6 0.7 1.3 -1.1 -0.2
Impedance of arm (left) 0.5 2.1 2.8 1.2 1.7
Arm fat mass (right) 0.9 3.6 6.0 1.1 -2.4
Trunk predicted mass 2.5 14.3 16.7 4.1 -3.5
Standing height 2.6 25.6 46.1 6.8 -2.2
Length of working week for main job 0.1 0.1 0.2 -0.0 0.5
Exposure to tobacco smoke at home 0.3 0.3 0.6 0.8 -0.2
Breastfed as a baby 0.2 0.2 0.4 0.2 -0.6
Tense / ‘highly strung’ 1.0 1.6 3.0 0.4 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 5.8 -0.1 2.4
Hair/balding pattern: Pattern 4 0.5 1.2 2.3 1.5 -0.3
Birth weight of first child 3.1 5.6 6.9 2.1 -2.6
Peak expiratory flow (PEF) 0.5 1.1 1.2 1.1 -0.9
Pulse wave reflection index 1.3 1.6 2.3 0.9 -1.5
Ever highly irritable/argumentative for 2 days 1.8 2.1 3.8 2.0 0.7
Loud music exposure frequency 2.3 2.5 5.0 0.1 2.2
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.0 0.0 -0.2
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 1.7 0.9 -1.3
Blood clot in the leg (DVT) 1.1 1.4 2.7 1.6 0.3
Medication: Paracetamol 0.9 1.5 3.0 -1.7 0.2
Headache pain in last month 2.4 4.2 4.5 1.9 2.1
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 1.7 0.8 1.3
Glaucoma (self-reported) 0.4 0.5 0.6 -0.8 0.6
Gout (self-reported) 1.3 1.7 1.8 -1.3 1.3
Hypothyroidism/myxoedema (self-reported) 3.5 6.8 11.5 3.4 -1.4
Medication: Amlodipine 0.1 0.2 0.3 0.1 0.5
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.4 0.3
Birth weight 1.3 2.9 3.5 1.5 -1.9
Chronic bronchitis/emphysema (mother) 5.8 6.7 9.8 3.1 1.9
High blood pressure (siblings) 0.3 0.4 0.7 -0.8 -0.3
Forced vital capacity (FVC), Best measure 0.6 2.3 4.3 2.1 -0.5
Body fat percentage 0.4 1.5 2.9 0.3 -1.7
Leg fat percentage (right) 0.3 1.2 1.7 -0.8 -1.3
Arm fat-free mass (right) 1.9 9.9 10.0 3.2 -3.1
Exposure to tobacco smoke outside home 1.3 1.8 3.4 1.9 0.4
Comparative body size at age 10 0.1 0.3 0.5 0.7 -0.1
Number of full brothers 1.3 1.7 2.4 -1.0 -1.5
Worry too long after embarrassment 0.3 0.5 0.5 0.6 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 3.0 3.9 7.8 -0.1 2.8
Wheeze or whistling in the chest in last year 1.0 1.8 2.0 -1.3 1.4
Number of children fathered 0.3 0.4 0.8 -0.9 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.0 -0.5 -1.0
Age at first live birth 0.1 0.2 0.3 -0.5 0.3
Pulse wave peak to peak time 1.1 1.3 2.6 1.6 -0.1
Health satisfaction 0.0 0.0 0.0 0.2 0.2
Shortness of breath walking on level ground 0.9 1.1 2.0 -1.4 0.3
Qualifications: College or University degree 0.5 1.6 3.1 1.8 -0.4
Eye problems/disorders: None of the above 0.0 0.0 0.0 0.1 0.1
Mouth/teeth dental problems: Loose teeth 2.5 2.9 5.9 -2.4 0.1
Emphysema/chronic bronchitis 1.1 1.2 2.3 -0.3 1.5
Medication for pain relief, constipation, heartburn 0.2 0.3 0.6 0.2 0.8
Neck or shoulder pain in last month 0.9 1.2 2.4 0.0 1.6
Medication: Blood pressure 0.4 0.7 0.9 -1.0 -0.7
Angina (self-reported) 0.7 0.9 1.4 -0.6 -1.2
Migraine (self-reported) 0.8 1.0 1.7 -1.3 0.6
Medication: Ibuprofen 0.5 0.6 1.1 -0.3 1.1
Medication: Allopurinol 1.7 2.3 3.5 -1.0 1.9
Medication: Omeprazole 0.2 0.3 0.5 -0.2 0.7
Medication: Seretide 50 evohaler 3.4 3.9 7.4 -0.7 2.7
Mean time to correctly identify matches 1.0 2.0 3.0 -1.7 0.9
Heart disease (mother) 2.1 2.6 4.2 -2.1 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.4 -1.2 0.2
Whole body fat mass 1.0 4.3 6.5 1.5 -2.5
Leg fat mass (right) 0.7 2.6 4.7 0.7 -2.2
Arm predicted mass (right) 2.0 10.3 11.0 3.3 -3.1
Pulse rate, automated reading 0.3 1.0 1.8 0.5 1.4
Alcohol intake frequency. 0.3 0.7 1.2 1.1 -0.5
Comparative height size at age 10 2.3 12.6 24.2 4.9 -1.0
Number of full sisters 1.0 1.2 1.6 -0.9 -1.3
Suffer from ‘nerves’ 1.1 1.7 3.2 -0.5 1.8
Overall health rating 1.0 2.1 4.0 0.5 2.0
Chest pain or discomfort 1.2 1.7 3.3 -0.3 1.8
Had major operations 0.1 0.1 0.3 0.0 -0.5
Age at last live birth 0.2 0.4 0.6 -0.4 -0.7
Family relationship satisfaction 1.8 2.2 4.1 2.0 0.6
Leg pain on walking 0.8 1.0 1.8 -1.4 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.5 -0.4 -0.7
Commuting to job workplace: Car/motor vehicle 2.4 2.7 4.8 0.8 -2.2
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.5 0.7 -1.2
Medication: Aspirin 0.9 1.1 1.5 1.2 -0.9
Supplements: Vitamin C 0.5 0.6 1.2 1.1 0.2
Knee pain experienced in last month 0.1 0.1 0.2 0.1 -0.5
Hypertension (Self-reported) 0.4 1.2 2.3 -1.5 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 1.6 -1.3 0.6
Illnesses of father: Heart disease 1.2 1.6 2.6 -0.8 1.6
Illnesses of siblings: Diabetes 0.3 0.4 0.5 0.7 -0.5
Smoking status: Previous 2.0 3.0 5.8 0.5 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.4 8.5 2.9 -0.7
Whole body fat-free mass 2.5 14.4 17.5 4.2 -3.4
Leg fat-free mass (right) 2.9 15.6 20.0 4.5 -3.3
Arm fat percentage (left) 0.5 1.8 3.3 0.6 -1.8
Average weekly red wine intake 1.9 2.7 4.1 2.0 1.2
Handedness (chirality/laterality): Left-handed 1.1 1.4 1.4 -1.1 -1.2
Mood swings 1.1 2.0 3.8 0.5 1.9
Loneliness, isolation 1.4 1.9 3.2 1.8 0.8
Long-standing illness, disability or infirmity 0.6 0.9 1.0 1.0 0.9
Ever had bowel cancer screening 8.5 10.0 15.1 -2.2 3.9
Diabetes diagnosed by doctor 1.2 2.0 3.9 -0.4 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 -0.4 -0.8
Friendships satisfaction 2.5 3.1 4.8 2.2 1.2
Qualifications: nursing, teaching 2.1 3.3 6.2 2.5 -0.7
Commuting to job workplace: Walk 0.7 0.7 1.0 0.7 1.0
Eye problems/disorders: Cataract 0.6 0.7 1.3 -0.3 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.8 1.3 -0.3
Medication for cholesterol 0.6 0.9 1.4 1.2 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.4 -0.5 1.6
Back pain experienced in last month 2.0 2.9 5.2 0.8 2.3
Mineral and other dietary supplements 1.6 2.1 3.2 -1.0 -1.8
Breast cancer (self-reported) 0.3 0.3 0.6 -0.8 0.1
Asthma (self-reported) 0.7 1.4 1.8 -1.0 1.3
Osteoporosis (self-reported) 0.7 0.8 1.5 0.3 -1.2
Osteoarthritis (self-reported) 0.0 0.1 0.1 0.0 0.3
Medication: Aspirin 0.3 0.4 0.4 0.6 -0.6
Medication: Gliclazide 0.9 1.1 2.0 -1.4 -0.4
Illnesses of father: None of the above (group 1) 0.4 0.5 0.9 0.1 1.0
Smoking status: Current 0.4 0.6 1.1 0.3 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.4 -0.6 -0.5
Whole body water mass 2.5 14.3 17.1 4.1 -3.4
Leg predicted mass (right) 2.9 15.5 19.6 4.4 -3.4
Arm fat mass (left) 1.1 4.5 6.8 1.5 -2.6
Number of self-reported non-cancer illnesses 0.8 1.5 1.5 -1.2 1.2
Average weekly champagne plus white wine intake 1.6 2.2 3.7 1.9 -0.9
Miserableness 1.1 1.9 3.6 -0.6 1.9
Guilty feelings 1.3 1.9 3.6 0.6 1.9
Wears glasses or contact lenses 0.3 0.4 0.7 -0.8 -0.1
Ever taken oral contraceptive pill 1.2 1.3 2.4 -1.6 -0.5
Hearing aid user 0.8 0.9 1.7 1.3 0.3
Mother’s age at death 0.1 0.1 0.2 0.1 0.4
Financial situation satisfaction 2.0 2.4 4.5 0.6 2.1
Tinnitus: Yes, now most or all of the time 0.5 0.5 0.6 -0.8 0.7
Commuting to job workplace: Public transport 0.6 0.7 1.2 -0.4 1.1
Eye problems/disorders: Glaucoma 0.3 0.4 0.5 -0.7 0.5
Medication: Blood pressure 0.6 1.2 2.4 -1.5 0.2
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 -0.5 -0.1
Supplements: Fish oil (including cod liver oil) 1.3 1.7 3.2 0.4 1.8
High cholesterol (Self-reported) 2.4 4.2 7.5 -1.0 -2.7
Medication: Bendroflumethiazide 1.6 2.4 4.8 -2.2 0.2
Medication: Paracetamol 1.3 2.0 3.9 -2.0 0.2
Medication: Lisinopril 0.2 0.2 0.3 0.6 -0.4
Medication: Atorvastatin 2.4 3.0 5.4 -0.8 -2.3
Illnesses of father: High blood pressure 0.6 0.8 1.3 1.1 -0.5
Alcohol drinker status: Never 0.3 0.3 0.5 -0.7 -0.4
Ever smoked 0.1 0.2 0.4 0.0 -0.6
Basal metabolic rate 2.5 14.0 16.4 4.0 -3.4
Leg fat percentage (left) 0.4 1.5 2.2 -0.9 -1.5
Arm fat-free mass (left) 1.9 9.7 10.2 3.0 -3.2
Number of operations (self-reported) 1.4 2.1 2.6 1.2 1.6
Average weekly beer plus cider intake 1.0 1.4 1.4 -1.2 1.2
Irritability 0.9 1.5 2.4 0.8 1.6
Risk taking 0.5 0.8 1.3 1.1 -0.5
Ever had prostate specific antigen (PSA) test 1.4 1.6 1.8 1.2 -1.3
Fractured/broken bones in last 5 years 1.1 1.4 2.3 1.5 -0.7
Age started oral contraceptive pill 0.7 0.9 1.7 1.3 0.2
Diastolic blood pressure, automated reading 2.4 7.3 11.6 -3.4 1.8
Ever depressed for a whole week 0.1 0.2 0.4 0.6 -0.1
Unable to work because of sickness or disability 1.7 2.2 2.4 -1.6 -1.4
Commuting to job workplace: Cycle 0.5 0.6 0.7 0.7 0.8
Myopia 0.1 0.2 0.3 -0.5 0.2
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.1 1.5 0.2
Cholesterol lowering medication 3.2 4.6 9.2 -0.2 -3.0
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.5 -0.7 0.7
Pain experienced in last month 0.6 1.0 1.5 -1.2 -0.7
Supplements: Calcium 2.1 2.3 3.1 1.8 1.2
Basal cell carcinoma (self-reported) 0.8 1.0 1.0 -1.0 1.0
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 -0.6 -0.4
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 2.9 1.7 0.3
Heart disease (siblings) 0.4 0.5 0.8 -0.5 -0.9
Alcohol drinker status: Previous 0.3 0.3 0.7 0.8 -0.2
Pack years of smoking 0.7 1.1 2.1 -0.2 -1.5
Impedance of whole body 0.7 3.5 6.7 -0.5 2.6
Leg fat mass (left) 0.7 2.8 5.2 0.6 -2.3
Arm predicted mass (left) 1.8 9.3 11.0 2.8 -3.3