Best TWAS P=1.37e-12 · Best GWAS P=5.73e-14 conditioned to 9.02e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ST3GAL4 | 0.06 | 0.00 | blup | 738 | 0.01 | 1.3e-02 | 3.7 | 6.4 | 1.3e-10 | -0.05 | 0.36 | 0.02 | TRUE |
2 | GTEx | Adipose Subcutaneous | TIRAP | 0.18 | 0.01 | enet | 38 | 0.05 | 4.8e-05 | -5.6 | 7.1 | 1.4e-12 | 0.02 | 0.13 | 0.39 | TRUE |
3 | GTEx | Brain Cortex | RP11-712L6.7 | 0.31 | 0.02 | lasso | 6 | 0.06 | 9.9e-03 | 1.3 | 5.2 | 2.1e-07 | -0.12 | 0.18 | 0.16 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | DCPS | 0.09 | 0.04 | lasso | 3 | 0.05 | 8.8e-05 | 5.8 | -5.5 | 4.0e-08 | -0.03 | 0.05 | 0.93 | FALSE |
5 | GTEx | Colon Transverse | TIRAP | 0.22 | 0.01 | enet | 28 | 0.09 | 4.0e-05 | -3.9 | 5.2 | 1.7e-07 | -0.09 | 0.20 | 0.12 | FALSE |
6 | GTEx | Esophagus Muscularis | CDON | 0.19 | 0.06 | lasso | 6 | 0.06 | 2.5e-04 | -4.4 | -5.7 | 9.5e-09 | 0.63 | 0.35 | 0.13 | FALSE |
7 | GTEx | Esophagus Muscularis | TIRAP | 0.14 | 0.01 | enet | 24 | 0.05 | 4.9e-04 | -3.7 | 5.5 | 3.0e-08 | -0.03 | 0.47 | 0.23 | FALSE |
8 | GTEx | Esophagus Muscularis | RP11-680F20.12 | 0.14 | 0.06 | lasso | 3 | 0.04 | 2.2e-03 | -4.4 | -5.9 | 3.0e-09 | 0.63 | 0.20 | 0.11 | TRUE |
9 | GTEx | Ovary | RP11-712L6.7 | 0.37 | 0.02 | enet | 9 | 0.07 | 6.9e-03 | -5.6 | 5.9 | 3.6e-09 | -0.06 | 0.08 | 0.13 | FALSE |
10 | GTEx | Thyroid | ST3GAL4 | 0.18 | 0.05 | lasso | 9 | 0.04 | 5.7e-04 | -5.5 | 5.5 | 2.8e-08 | -0.32 | 0.29 | 0.48 | TRUE |
11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DCPS | 0.08 | 0.03 | enet | 10 | 0.04 | 2.9e-09 | 5.8 | -5.3 | 1.2e-07 | -0.03 | 0.02 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DCPS | 0.06 | 0.04 | enet | 10 | 0.05 | 1.3e-06 | 5.8 | -5.6 | 1.7e-08 | -0.06 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DCPS | 0.04 | 0.05 | lasso | 2 | 0.05 | 5.9e-06 | 5.8 | -5.3 | 1.1e-07 | -0.04 | 0.01 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCPS | 0.11 | 0.10 | lasso | 3 | 0.09 | 1.0e-09 | 5.8 | -5.6 | 1.7e-08 | -0.05 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | DCPS | 0.12 | 0.02 | blup | 80 | 0.05 | 2.2e-04 | 6.1 | -6.0 | 2.2e-09 | -0.09 | 0.00 | 0.99 | FALSE |