TWAS hub - ST3GAL4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0620	0.0240	4.8e-03	0.003	0.012	0.009	0.011	0.008	1.3e-01	1.3e-02	2.5e-02	1.5e-02	3.5e-02
2	GTEx	Brain Putamen basal ganglia	0.2950	0.1040	6.7e-03	-0.009	NA	-0.008	NA	-0.009	6.2e-01	NA	5.3e-01	NA	6.2e-01
3	GTEx	Thyroid	0.1790	0.0520	6.1e-04	0.049	NA	0.035	NA	0.039	1.2e-04	NA	9.9e-04	NA	5.7e-04
4	YFS	Blood	0.0475	0.0117	1.5e-07	0.010	0.023	0.024	0.025	0.023	2.5e-04	2.7e-08	1.4e-08	1.1e-08	2.7e-08
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0443	0.0220	8.8e-03	-0.002	0.001	0.000	NA	0.004	7.0e-01	2.7e-01	2.7e-01	NA	9.9e-02
6	TCGA	Brain Lower Grade Glioma	0.0818	0.0289	2.5e-04	0.037	0.020	0.032	NA	0.048	4.6e-05	2.3e-03	1.3e-04	NA	3.5e-06
7	TCGA	Prostate Adenocarcinoma	0.1099	0.0337	9.3e-07	0.048	0.053	0.075	NA	0.069	8.3e-06	3.3e-06	3.0e-08	NA	1.0e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
LDL Cholesterol	10.8	17.1	45.0	1.7	0.7	3.3	-2.6	4.6	6.7	5.7
Illnesses of father: Heart disease	5.9	8.1	31.9	-1.2	-0.2	1.0	0.1	2.0	4.3	5.6
High cholesterol (Self-reported)	5.4	9.6	36.6	-2.4	-0.2	0.8	-2.8	2.5	3.2	6.0
Coronary Artery Disease (CAD)	4.8	5.7	21.6	-1.2	0.5	1.5	-1.7	2.2	2.6	4.7
Medication: Cholesterol lowering	4.5	6.9	26.9	-1.5	0.8	-0.4	-2.0	2.2	3.1	5.2
Medication: Simvastatin	4.2	6.1	19.3	-2.6	-0.3	-0.1	-2.4	2.3	2.4	4.4
Illnesses of father: None of the above (group 1)	3.6	4.5	13.1	1.6	-1.8	-1.3	0.7	-1.1	-3.0	-3.6
Diabetes (father)	3.1	3.9	9.9	0.4	3.1	-1.6	1.4	-1.5	-2.2	-2.3
Osteoporosis (self-reported)	3.1	3.9	11.9	-0.6	-1.0	-2.2	-0.8	-0.6	-3.4	-2.8
Medication: Seretide 50 evohaler	2.7	3.1	10.4	-1.1	0.2	1.7	-2.0	3.2	0.1	1.8
Knee pain experienced in last month	2.7	4.2	9.0	-0.5	2.4	-3.0	0.3	-1.9	-2.6	-2.0
Major Depression (MDD)	2.4	2.9	8.6	-0.3	2.9	-0.6	-1.7	2.8	0.0	-0.4
Hair/balding pattern: Pattern 2	2.4	3.0	12.0	-1.7	1.1	-0.6	0.2	0.4	-3.5	-2.1
Alcohol intake frequency.	2.3	5.4	10.8	-3.3	2.4	-1.0	-3.2	-0.5	1.4	2.8
Illnesses of mother	2.2	2.8	9.4	-2.2	1.0	-0.3	-3.1	0.5	-1.8	-0.7
Leg fat percentage (left)	2.2	7.8	24.3	-4.9	2.4	-1.4	-3.6	-1.8	-0.1	2.5
Alzheimer’s Disease (in father)	2.1	2.3	6.5	-0.4	0.0	0.8	-1.5	2.4	1.1	2.5
Systolic blood pressure, automated reading	2.1	6.1	16.1	-2.4	-0.7	3.3	-0.6	2.4	1.8	4.0
Hand grip strength (right)	2.1	5.7	18.5	4.3	-1.3	2.4	2.2	1.4	2.6	0.3
Average weekly fortified wine intake	2.1	2.5	6.4	2.5	-0.6	-0.7	0.0	1.4	2.5	1.5
Peak expiratory flow (PEF)	2.1	4.8	14.8	3.9	-1.7	-0.0	3.0	-1.7	0.4	-1.9
Leg fat percentage (right)	2.1	7.5	21.8	-4.7	2.3	-1.5	-3.5	-2.1	-0.1	2.6
Angina (self-reported)	2.1	2.7	8.5	-1.5	1.5	-2.9	-1.1	-0.6	0.9	1.9
Hand grip strength (left)	2.0	5.2	17.8	4.2	-0.8	2.7	2.2	1.0	2.1	-0.0
Angina	2.0	2.6	8.4	-1.6	1.3	-2.9	-1.1	-0.6	0.7	1.8
Medication: Metformin	2.0	2.8	6.3	-0.9	0.4	-2.5	-0.1	-2.3	-2.1	-1.7
Diabetes (mother)	2.0	2.6	8.6	1.2	-0.8	-0.9	1.8	-2.9	-1.0	-1.6
Lung FEV1/FVC ratio	1.9	9.6	36.6	-0.5	-0.2	-6.1	3.3	-4.1	-1.0	-1.4
Medication: Atenolol	1.9	2.4	9.5	-1.3	0.3	-0.4	-0.2	-0.7	2.2	3.1
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	10.9	0.2	1.1	-3.3	0.7	-0.3	-1.9	-0.9
Heart disease (mother)	1.9	2.4	12.7	0.2	-0.3	0.6	-0.3	0.9	1.5	3.6
Family relationship satisfaction	1.9	2.4	6.5	1.4	-1.3	0.9	0.9	2.5	2.2	0.4
HDL Cholesterol	1.8	3.1	12.3	1.2	-1.0	0.1	1.4	-0.4	-2.2	-3.5
Blood Eosinophil Count	1.8	14.1	25.6	3.7	0.6	-0.7	4.8	-5.1	-3.5	-4.9
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	6.9	-2.6	1.0	-1.2	-1.7	-0.0	-0.5	1.8
Age when periods started (menarche)	1.8	4.3	9.1	2.6	-3.0	2.2	2.7	-1.1	0.2	-0.9
Pulse wave Arterial Stiffness index	1.8	2.1	8.1	0.3	0.1	1.5	1.1	-0.9	2.8	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	12.1	2.8	0.1	2.3	0.5	0.5	3.5	0.8
Medication for cholesterol	1.8	2.7	11.3	0.6	0.6	0.5	0.9	-0.4	-2.4	-3.4
Average weekly spirits intake	1.7	2.1	5.8	-0.3	-0.3	-2.4	-1.2	0.4	-2.4	-1.1
Sitting height	1.7	12.2	58.2	3.7	1.0	7.6	1.9	-0.5	2.9	-0.7
Medication: Omeprazole	1.7	2.1	8.1	-0.4	-0.6	-0.8	-0.5	0.1	-2.8	-2.2
Chest pain or discomfort	1.7	2.5	11.4	-0.0	0.0	-3.4	-0.6	1.2	0.8	1.9
Forced vital capacity (FVC)	1.6	6.2	15.3	3.9	-2.3	3.2	2.6	1.2	1.5	-1.4
Heart attack	1.6	2.1	8.5	-1.2	0.8	-0.9	0.1	0.0	1.8	2.9
Arm fat percentage (right)	1.6	6.1	18.1	-4.3	0.9	-0.9	-3.7	-1.8	-0.3	2.5
Medication: Lansoprazole	1.6	1.8	4.8	-0.8	-2.0	0.6	-2.2	0.9	1.0	1.1
Medication for pain relief, constipation, heartburn	1.6	2.7	7.6	2.8	1.1	2.1	1.7	0.4	1.3	-1.0
Cholesterol lowering medication	1.6	2.4	10.0	-1.2	-0.6	-0.7	-1.2	1.1	1.3	3.2
Relative age of first facial hair	1.5	3.1	8.6	-1.2	-1.7	0.8	-2.9	1.2	0.3	2.5
Medication: Co-codamol	1.5	1.7	4.5	-1.5	-0.5	-0.9	-2.1	-0.0	-1.7	1.1
Happiness	1.5	1.8	5.0	1.8	-0.3	0.3	0.0	2.2	1.9	0.9
Standing height	1.5	14.7	41.2	6.4	0.5	5.5	4.1	0.7	3.7	-0.0
Mineral and other dietary supplements	1.5	2.0	11.6	-0.8	3.4	0.7	-0.1	1.0	0.6	0.5
Medication: Gliclazide	1.5	1.7	5.2	0.9	-0.1	-1.5	1.4	-0.4	-2.3	-1.3
Ever taken oral contraceptive pill	1.5	1.6	6.2	2.5	-0.5	-0.4	1.8	0.1	1.1	-0.5
Medication: Atorvastatin	1.5	1.9	6.5	0.1	0.6	-0.3	-0.6	0.9	2.2	2.6
Ever smoked	1.5	2.6	5.6	2.3	-1.2	1.0	2.0	0.6	-0.6	-2.4
Heart attack/myocardial infarction (self-reported)	1.5	2.0	8.2	-1.4	0.6	-0.6	0.1	-0.0	1.7	2.9
Prostate Cancer	1.4	2.0	5.0	1.8	1.0	2.2	1.7	0.2	1.0	0.9
Pack years adult smoking proportion	1.4	2.1	3.9	0.9	1.9	0.8	2.0	-0.9	-1.3	-1.8
Medication: Paracetamol	1.4	2.3	5.6	-2.4	-1.7	-1.1	-2.3	0.1	-0.8	0.5
Body fat percentage	1.4	5.7	14.4	-3.8	2.4	-0.5	-3.4	-1.8	0.1	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	3.9	-0.6	-2.0	1.9	-1.7	0.5	0.3	-0.5
Arm fat percentage (left)	1.4	5.7	16.3	-4.0	1.1	-1.4	-3.4	-1.9	-0.0	2.4
Vascular/heart problems diagnosed by doctor	1.4	3.7	11.4	1.9	-1.1	1.2	1.5	0.0	-2.5	-3.4
Heart disease (siblings)	1.4	1.8	4.7	-1.6	1.3	0.9	-0.8	1.2	0.8	2.2
Triglycerides	1.3	2.1	5.2	1.5	2.3	0.8	-0.2	0.1	1.5	2.0
Blood White Count	1.3	9.4	22.2	-3.3	0.4	-0.5	-3.8	-3.8	-4.7	-2.1
Height	1.3	25.3	79.9	8.9	1.4	7.1	5.2	-0.1	4.1	0.3
Cardiovascular Disease	1.3	4.3	13.8	-0.7	0.8	0.0	-0.8	2.0	3.2	3.7
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	3.8	0.7	1.0	-0.5	-1.2	1.9	1.2	1.0
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	3.8	1.4	-1.0	0.4	0.4	0.6	1.8	1.9
Body mass index (BMI)	1.3	5.5	18.3	-4.3	1.3	-0.9	-2.7	-1.6	0.0	2.8
Had other major operations	1.3	1.5	2.6	-1.2	0.5	-1.4	-1.4	-1.6	-0.9	-1.2
Illnesses of siblings	1.3	1.9	7.2	-0.1	0.3	-1.0	-0.2	-0.1	-2.2	-2.7
Father’s age at death	1.3	1.8	5.6	0.1	1.1	0.0	1.2	-0.3	-2.0	-2.4
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	12.0	3.5	-2.2	1.1	3.0	-0.2	1.3	-1.4
Ever highly irritable/argumentative for 2 days	1.3	1.5	4.8	0.3	-1.3	-1.4	-0.5	0.4	1.3	2.2
Pulse wave peak to peak time	1.3	1.6	6.2	0.0	-0.2	-1.1	-1.0	0.9	-2.5	-1.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	5.6	1.1	-2.4	-0.4	0.9	-1.7	-0.8	-0.7
Illnesses of father: High blood pressure	1.3	1.6	7.8	-0.4	0.8	2.8	-0.3	1.4	0.5	0.8
Pack years of smoking	1.3	1.9	4.2	0.4	1.7	0.8	2.1	-1.0	-1.5	-1.5
Alzheimer’s Disease (in mother)	1.2	1.4	4.3	0.2	1.1	-0.7	1.5	-2.1	-0.1	-1.1
Primary Biliary Cirrhosis	1.2	1.7	5.0	0.3	-0.1	-2.2	1.3	-2.1	-0.3	-0.4
Systolic Blood Pressure	1.2	5.9	18.1	-1.5	-0.5	1.6	-0.4	3.1	3.0	4.2
Number of treatments/medications taken	1.2	2.2	8.3	-2.9	0.0	-0.4	-1.4	-0.5	-0.4	2.1
Forced vital capacity (FVC), Best measure	1.2	4.2	9.9	3.1	-2.1	2.9	1.7	0.6	1.3	-1.5
Medication: Ibuprofen	1.2	1.5	4.7	0.2	0.4	-2.2	1.4	-0.3	-1.6	-0.8
Comparative height size at age 10	1.2	6.6	20.8	4.6	1.9	1.8	3.5	1.3	2.0	-0.9
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	6.1	-0.6	-0.1	-1.5	-1.1	2.5	-0.3	2.0
Number of self-reported non-cancer illnesses	1.2	2.0	6.2	-2.5	0.8	-0.8	-1.0	-0.1	0.2	2.4
Financial situation satisfaction	1.2	1.5	5.7	2.4	-0.1	0.6	0.7	1.8	0.4	-0.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	4.8	0.7	0.5	-0.2	2.2	-0.2	-1.1	-1.7
Supplements: Calcium	1.2	1.4	3.6	-1.9	-0.6	-1.0	-1.3	-0.8	-1.5	-0.3
Alcohol drinker status: Previous	1.2	1.3	5.5	-1.4	0.9	-0.8	-2.3	-0.6	0.2	0.5
Mean Putamen Volume	1.1	1.2	3.1	1.3	0.7	-0.3	0.6	-1.3	-1.1	-1.8
Trunk fat percentage	1.1	4.4	10.2	-3.0	2.2	0.4	-3.2	-1.7	0.2	1.8
Serious illness, injury or assault to yourself	1.1	1.3	2.7	-1.7	1.5	-0.6	-0.4	0.9	0.8	1.4
High blood pressure (mother)	1.1	1.5	5.0	0.4	1.0	0.8	1.3	1.1	2.2	0.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	7.8	0.7	-1.0	1.1	0.5	-1.0	-1.1	-2.8
High blood pressure (siblings)	1.1	1.7	5.9	1.0	-0.4	-0.4	0.4	0.2	2.4	2.0
Leg fat mass (right)	1.1	4.4	8.9	-3.0	2.0	-0.5	-2.4	-2.0	0.7	2.7
Handedness (chirality/laterality): Left-handed	1.1	1.3	6.0	1.4	-2.5	-0.2	0.6	0.6	0.6	0.5
Friendships satisfaction	1.1	1.3	5.4	-0.0	-1.2	-0.4	-0.9	2.3	1.1	-0.0
Osteoarthritis (self-reported)	1.1	1.4	4.8	-1.5	1.3	-2.2	0.4	0.1	-0.9	0.2
Diastolic blood pressure, automated reading	1.1	3.3	7.7	-2.4	0.1	2.0	-0.7	0.8	2.1	2.8
Ever depressed for a whole week	1.1	1.4	8.0	-0.7	-1.0	0.0	-2.8	0.6	-0.0	-0.3
Pain experienced in last month	1.1	1.9	6.5	1.3	-2.6	1.8	0.2	0.8	0.0	-1.0
Leg fat mass (left)	1.1	4.3	9.9	-3.1	2.0	-0.4	-2.4	-1.7	0.7	2.7
Lupus	1.0	1.5	3.7	1.9	-1.3	-0.4	1.3	0.6	-0.5	-1.6
BMI	1.0	5.6	14.8	-3.9	1.8	-2.2	-2.9	-1.6	0.5	2.3
Hearing difficulty/problems: Yes	1.0	1.5	4.4	1.1	0.4	-2.1	1.4	0.1	-1.4	-0.9
Maternal smoking around birth	1.0	1.5	6.7	-1.1	0.9	-2.6	-0.1	-0.5	-0.8	-1.0
Taking other prescription medications	1.0	1.6	5.9	-2.4	0.3	0.3	-1.3	-1.1	-1.4	0.1
Medication: Levothyroxine sodium	1.0	1.7	3.3	-0.6	-1.5	-0.3	-1.5	1.6	1.0	1.8
Mouth/teeth dental problems	1.0	1.5	4.3	2.1	-0.4	0.6	1.4	-1.1	-0.7	-1.4
Diabetes (self-reported)	1.0	1.5	3.5	-1.0	-0.3	-1.7	-0.5	-0.8	-1.4	-1.9
Hip circumference	1.0	4.5	14.3	-2.0	1.3	1.0	-2.0	0.1	2.6	3.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	6.6	2.6	-1.9	1.3	2.5	-0.9	1.1	-1.3
Arm fat mass (right)	1.0	4.0	9.5	-3.1	1.1	0.1	-2.6	-1.7	0.7	2.7
Birth weight	1.0	2.1	9.5	3.1	-1.1	1.8	0.5	0.3	0.2	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.7	1.1	0.0	0.6	1.2	0.1	-0.7	-2.2
Neck or shoulder pain in last month	1.0	1.4	4.0	1.5	0.3	-2.0	1.7	-0.4	-0.5	-0.2
Leg pain on walking	1.0	1.3	4.4	0.1	0.1	-1.4	-0.2	-1.3	-2.1	-0.9
Arm fat mass (left)	1.0	4.0	9.2	-3.0	1.1	-0.1	-2.3	-1.6	0.9	2.9
Miserableness	1.0	1.8	8.3	2.9	-0.5	1.3	1.4	0.1	0.3	0.6
Medication: Blood pressure	1.0	1.8	5.3	-2.1	-0.1	-0.1	-1.1	-0.5	1.3	2.3
Medication: Paracetamol	1.0	1.5	4.6	-1.5	-2.1	-0.2	-1.6	-0.0	-0.0	1.1
Fractured/broken bones in last 5 years	1.0	1.3	5.1	-2.3	0.1	1.7	-0.6	-0.3	0.6	-0.1
Age started oral contraceptive pill	1.0	1.3	4.0	-1.1	-1.4	2.0	-0.1	0.9	0.3	1.0
Commuting to job workplace: Cycle	1.0	1.3	3.8	-0.1	-1.6	-1.2	2.0	-1.0	0.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.4	-0.3	-1.3	-1.0	-0.8	0.4	-1.8	-1.2
Depression (Nagel 2018)	0.9	1.3	4.4	0.8	2.1	-0.2	1.0	0.3	0.8	1.6
HbA1C	0.9	1.0	5.8	-2.4	-0.0	0.4	-0.1	-0.3	-0.2	0.7
Rheumatoid Arthritis	0.9	1.2	4.0	-0.3	0.7	0.2	0.2	-1.9	-2.0	-0.1
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.8	-1.1	0.4	-1.7	-0.2	-1.1	-1.7	-1.9
Qualifications: CSEs or equivalent	0.9	1.2	3.9	-0.1	0.2	-0.7	-1.6	2.0	-1.2	-0.1
Waist circumference	0.9	3.1	9.2	-3.0	1.1	-0.3	-1.5	-1.7	0.2	2.5
Past tobacco smoking	0.9	1.7	4.1	-1.5	1.5	-0.2	-1.6	-0.2	0.9	2.0
Medication: Ramipril	0.9	1.1	4.2	-0.1	-0.2	0.6	-0.5	-0.7	1.5	2.1
Worrier / anxious feelings	0.9	1.6	3.3	1.2	0.0	1.0	-0.1	1.5	1.8	1.8
Qualifications: A levels/AS levels or equivalent	0.9	1.9	4.2	1.7	-1.6	-1.2	1.2	0.8	2.0	-0.2
Breastfed as a baby	0.9	1.1	2.9	-0.5	-1.3	-0.4	-0.7	1.7	1.0	1.2
Hair/balding pattern: Pattern 4	0.9	2.3	6.5	0.9	0.9	-1.8	0.3	-1.9	1.1	-2.5
Birth weight of first child	0.9	1.6	4.2	-1.6	1.6	-0.7	-0.9	-0.3	-0.7	-2.0
Headache pain in last month	0.9	1.6	4.2	-1.2	1.3	-2.0	-0.2	-1.0	1.2	1.2
Gout (self-reported)	0.9	1.2	2.6	-1.5	-1.6	0.4	-1.0	-1.0	-1.1	-0.3
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.7	-1.5	0.1	-1.5	-1.6	0.2	0.3	1.0
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.2	-0.4	0.3	-1.7	0.3	1.1	1.8	0.3
Medication: Allopurinol	0.9	1.2	4.9	-2.2	-0.5	0.6	-0.9	-1.1	-0.2	0.8
Whole body fat mass	0.9	3.7	6.8	-2.6	2.3	0.2	-2.0	-1.9	0.8	2.4
Overall health rating	0.9	1.8	5.1	-1.6	0.6	-0.1	-2.1	0.6	-0.3	2.3
Diabetes diagnosed by doctor	0.9	1.5	3.9	-1.2	0.2	-2.0	-0.6	-1.2	-1.3	-1.4
Average weekly champagne plus white wine intake	0.9	1.3	2.6	1.6	0.9	-1.0	1.1	-0.8	1.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	5.2	-0.1	-0.7	-0.6	1.2	-0.1	0.3	2.3
Medication: Bendroflumethiazide	0.9	1.4	4.5	-0.1	-1.8	0.8	0.8	-0.3	0.9	2.1
Number of operations (self-reported)	0.9	1.3	2.2	-1.1	1.5	-1.0	-1.3	-1.4	-1.0	-0.6
Average weekly beer plus cider intake	0.9	1.4	6.0	-0.2	-1.6	2.4	-0.7	0.2	-0.5	-0.1
Irritability	0.9	1.5	3.6	1.3	-1.1	-1.4	1.3	-0.9	-1.9	-0.2
Worry (Nagel 2018)	0.8	1.8	5.0	1.5	-0.3	0.6	-0.5	2.2	1.7	1.3
Fasting Glucose	0.8	0.9	4.6	0.2	-0.9	0.8	2.1	-0.3	0.7	0.0
High blood pressure	0.8	2.3	6.2	-1.8	0.1	-0.4	-1.9	0.5	1.7	2.5
Multivitamins +/- minerals	0.8	1.0	3.0	0.8	-1.2	-0.4	0.1	-0.4	-1.2	-1.7
Trunk fat mass	0.8	3.2	5.0	-2.2	2.1	0.6	-2.1	-1.9	0.8	2.0
Hearing difficulty/problems with background noise	0.8	1.3	4.1	1.6	-0.1	-0.4	2.0	1.5	0.4	0.2
Qualifications: None of the above	0.8	1.6	4.8	-2.2	1.6	1.1	0.1	-0.2	-1.7	-0.1
Pain all over the body in last month	0.8	0.9	2.8	-0.5	1.2	-0.4	0.3	-0.5	-1.1	-1.7
Depression (self-reported)	0.8	0.9	4.6	0.6	0.7	0.2	0.1	-2.2	-0.8	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.5	0.4	0.5	-0.7	-0.8	1.4	1.2	1.9
Comparative body size at age 10	0.8	2.1	6.8	-1.6	-0.4	-1.5	-2.6	0.7	1.1	1.0
Number of children fathered	0.8	0.9	3.4	-0.2	-0.0	1.8	-1.4	0.2	-0.4	0.6
Medication: Aspirin	0.8	1.1	5.2	-2.3	-0.4	-0.8	-0.5	-0.4	-0.1	1.1
Ever had bowel cancer screening	0.8	0.9	3.6	-1.9	0.6	-0.3	-1.2	-0.4	-0.8	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	4.0	0.3	-0.8	-2.0	0.5	-0.1	-0.6	-0.7
Medication: Aspirin	0.8	1.0	4.1	-2.0	-0.1	-0.4	-1.1	0.1	0.2	1.4
Wears glasses or contact lenses	0.8	1.0	2.6	1.0	0.3	-0.0	1.3	-0.4	1.1	1.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.9	1.0	1.1	-1.4	-0.4	0.5	1.1	0.7
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.5	0.7	-2.3	1.0	-2.0	-0.8	-0.9	-1.7
Schizophrenia vs Biploar Disorder	0.7	1.0	2.5	1.0	1.0	1.0	-1.6	0.7	0.4	0.8
Bipolar Disorder (2011)	0.7	0.6	3.1	-1.8	0.9	-0.4	-0.5	0.0	0.0	0.0
Neuroticism (2016)	0.7	1.0	2.8	1.7	0.8	-0.2	-0.3	0.6	0.7	1.6
Smoking Status	0.7	1.7	4.6	1.4	0.3	-1.2	2.1	-0.9	-0.3	-1.8
Lung FVC	0.7	3.8	9.3	1.7	-2.4	2.8	3.0	0.1	0.5	-0.5
Townsend deprivation index at recruitment	0.7	1.0	4.2	-2.0	0.7	-0.4	-0.8	0.3	-1.1	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.2	-1.0	1.5	0.4	-0.9	1.1	1.3	1.8
Stomach or abdominal pain in last month	0.7	0.9	3.1	-0.8	-1.8	-0.8	-0.9	-0.4	-0.1	1.0
Alcohol usually taken with meals	0.7	1.1	5.0	0.2	1.2	-0.4	0.1	-2.2	0.7	-0.5
Trunk fat-free mass	0.7	3.9	6.6	2.2	0.1	2.6	2.4	-0.4	2.5	1.9
Number of live births	0.7	0.9	1.9	-1.0	-0.8	-0.1	0.4	-1.3	-1.4	-1.0
Mouth/teeth dental problems: Dentures	0.7	1.1	4.5	-1.1	-0.6	1.1	0.1	-2.1	-0.7	0.4
Trunk predicted mass	0.7	4.0	6.9	2.2	0.1	2.6	2.5	-0.4	2.5	1.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.2	-0.3	-0.4	-0.7	-0.6	1.2	1.5	1.1
Blood clot in the leg (DVT)	0.7	0.9	4.0	-0.4	-0.1	-0.9	0.9	2.0	0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.5	1.2	0.3	1.0	1.6	-0.9	0.1	0.1
Exposure to tobacco smoke outside home	0.7	1.0	2.4	0.2	1.0	-0.9	-0.6	1.6	0.8	1.3
Number of full brothers	0.7	0.9	2.0	0.6	0.1	1.4	1.3	-0.8	-1.2	-0.3
Hypertension (Self-reported)	0.7	2.0	5.4	-1.8	0.3	-0.8	-1.5	0.3	1.5	2.3
Long-standing illness, disability or infirmity	0.7	1.1	4.6	-2.1	1.0	-0.8	-0.5	0.2	-0.4	0.8
Back pain experienced in last month	0.7	1.0	1.6	-1.3	1.2	-1.0	-0.7	1.0	0.3	1.1
Guilty feelings	0.7	1.1	3.6	0.9	-1.9	-1.2	0.2	0.4	-1.2	-0.3
Risk taking	0.7	1.0	4.1	-1.0	2.0	-0.7	0.2	-0.5	-0.2	-0.9
Basal cell carcinoma (self-reported)	0.7	0.9	5.4	-0.4	-0.1	-2.3	0.2	-0.1	-0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	4.4	-0.5	-0.1	-1.0	0.8	2.1	0.3	0.0
Bipolar Disorder (2018)	0.6	0.9	1.9	-1.4	0.7	0.3	0.2	-0.7	-1.4	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.5	0.8	0.1	-1.6	0.1	0.5	-0.6	-1.2
Blood Platelet Count	0.6	6.8	28.9	-1.8	-0.4	-2.7	-0.5	5.4	-2.5	1.2
Waist Hip Ratio (WHR)	0.6	2.7	9.6	-0.9	0.6	-0.2	1.1	-2.3	-3.1	-1.4
Allergy or Eczema	0.6	1.6	4.5	-0.6	-0.2	-0.3	1.7	-2.1	-0.9	-1.6
Hypothyroidism (self reported)	0.6	1.5	4.4	-1.8	-0.7	-0.5	-2.1	0.7	-1.3	-0.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.3	1.0	0.7	-0.2	1.1	1.5	0.1	1.0
Vitamin and mineral supplements	0.6	0.8	1.8	-0.2	1.3	0.5	0.6	0.0	1.1	1.4
Current tobacco smoking	0.6	1.0	3.0	0.2	1.1	-0.6	0.4	-0.6	-1.5	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.3	0.8	1.3	0.2	0.7	-0.6	0.1	1.5
Nervous feelings	0.6	1.2	3.1	0.6	0.5	1.6	-0.7	1.7	1.0	0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	-0.5	-1.1	-0.7	-1.3	1.0	0.1	-0.4
Lung cancer (father)	0.6	0.6	1.2	0.7	-0.8	0.6	0.8	-1.0	-0.4	-1.1
Exposure to tobacco smoke at home	0.6	0.7	2.1	-0.8	0.3	1.2	-1.4	-0.3	0.4	0.3
Glaucoma (self-reported)	0.6	0.8	2.6	-0.1	-1.4	-0.1	-0.1	-0.5	-1.6	0.6
Arm fat-free mass (right)	0.6	2.8	6.2	1.2	1.4	1.6	1.9	-0.7	2.5	1.9
Health satisfaction	0.6	0.8	2.2	1.5	-0.3	-1.1	-1.0	-0.1	0.0	-0.9
Eye problems/disorders: None of the above	0.6	0.7	2.3	0.5	0.7	0.9	-1.5	-0.1	0.3	-1.0
Arm predicted mass (right)	0.6	3.0	7.1	1.4	1.2	1.6	1.9	-0.3	2.7	2.1
Had major operations	0.6	0.7	1.4	-1.0	0.9	-1.0	-0.7	0.1	-1.2	-0.4
Illnesses of siblings: Diabetes	0.6	0.7	1.6	-1.3	0.9	-0.5	0.1	-1.1	-0.8	-0.4
Qualifications: nursing, teaching	0.6	0.9	2.9	1.7	0.4	-0.9	-0.8	-0.4	-0.0	-1.2
Eye problems/disorders: Cataract	0.6	0.7	1.7	1.1	-1.1	-0.8	1.3	-0.5	0.2	0.1
Smoking status: Current	0.6	0.9	2.9	0.1	0.7	-0.4	0.3	-0.2	-1.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	5.9	1.1	-2.4	-0.9	-0.3	-0.2	-0.7	-0.8
Whole body water mass	0.6	3.2	5.7	1.7	0.6	2.4	2.1	-0.8	2.2	1.9
Commuting to job workplace: Public transport	0.6	0.8	2.9	0.6	-1.7	0.5	0.2	0.1	-0.4	-1.3
Medication: Lisinopril	0.6	0.7	1.9	-0.6	-0.4	-1.0	0.1	-0.5	-1.4	-1.3
Arm fat-free mass (left)	0.6	3.1	5.6	1.0	1.3	2.4	1.7	-0.3	2.3	2.3
Myopia	0.6	0.9	2.2	0.5	-1.1	1.2	-0.5	0.5	0.7	1.5
Arm predicted mass (left)	0.6	3.0	6.0	0.6	1.3	2.3	1.4	-0.4	2.3	2.5
Neuroticism (Nagel 2018)	0.5	1.1	4.9	2.2	-0.3	-0.1	0.7	0.5	0.9	0.9
Schizophrenia (2018)	0.5	1.1	3.1	1.1	-0.5	-1.7	-0.2	0.9	0.6	-1.5
Ulcerative Colitis	0.5	0.7	4.3	-0.6	0.6	-2.1	0.2	0.1	0.0	-0.0
Heel T-Score	0.5	4.3	10.0	-0.4	-0.6	-1.7	-1.2	3.2	2.5	3.0
Sensitivity / hurt feelings	0.5	0.8	4.5	-0.7	0.1	-0.5	-0.1	-2.1	-0.7	0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.8	-1.3	-0.9	0.8	-0.4	-0.2	-1.0	0.7
Supplements: Zinc	0.5	0.5	1.5	1.2	-0.1	-0.0	-0.2	1.2	0.6	-0.0
Severe depression (siblings)	0.5	0.5	2.7	0.3	1.6	-0.0	0.3	0.7	-0.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.9	0.4	1.7	0.0	0.7	0.2	0.3	1.2
Financial difficulties in last 2 years	0.5	0.7	1.5	0.9	0.1	1.2	1.2	-0.6	0.8	0.7
Weight	0.5	2.5	6.6	-1.2	1.6	1.4	-0.8	-1.3	1.7	2.6
Time employed in main current job	0.5	0.5	1.4	-0.1	-1.2	-1.2	0.7	-0.2	0.6	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	-1.2	1.5	-0.8	-0.5	-0.7	-0.2	0.5
Pulse rate	0.5	0.8	3.7	0.2	0.0	0.1	0.9	-1.9	-0.5	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.8	-0.4	0.5	-1.4	-0.9	-0.5	0.6	0.8
Pulse wave reflection index	0.5	0.7	1.7	-0.6	-0.1	0.2	1.3	-0.8	1.3	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.4	1.0	-1.1	-0.8	0.6	-0.6	1.2	0.2
Shortness of breath walking on level ground	0.5	0.6	1.9	0.5	0.6	-1.4	-1.2	0.2	0.1	0.0
Pulse rate, automated reading	0.5	1.5	4.0	1.3	1.0	-0.2	2.0	-1.9	-0.7	-0.5
Age at last live birth	0.5	0.7	3.9	0.4	0.4	0.5	-2.0	-0.1	0.5	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	-0.6	0.4	-0.6	-1.4	-0.4	0.6	0.9
Supplements: Vitamin C	0.5	0.6	1.5	1.2	0.0	-0.6	0.4	-0.6	-0.8	-0.9
Whole body fat-free mass	0.5	2.9	5.0	1.8	0.3	2.2	2.0	-0.8	2.1	1.8
Eye problems/disorders: Glaucoma	0.5	0.6	2.5	-0.2	-1.2	0.0	-0.1	0.2	-0.5	1.6
Basal metabolic rate	0.5	2.5	4.7	1.2	0.7	2.2	1.4	-0.9	2.1	2.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.2	1.0	-1.2	1.5	-0.3	0.4	-0.5	-1.3
Ovarian Cancer	0.4	0.5	2.4	0.2	0.4	1.6	-0.5	-0.3	0.8	-0.0
Respiratory disease	0.4	0.9	2.8	0.0	1.0	-0.4	0.5	-0.4	-1.2	-1.7
Ever had hysterectomy (womb removed)	0.4	0.5	1.5	-1.2	-0.0	0.5	-1.2	-0.5	-0.3	-0.1
Leg fat-free mass (left)	0.4	1.9	3.1	1.2	0.4	1.7	1.2	-1.3	1.8	1.7
Relative age voice broke	0.4	0.5	1.3	-0.1	-0.3	0.3	-1.1	1.1	-0.9	0.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	-0.3	-0.5	0.1	1.1	-1.4	-0.6	-1.3
Supplements: Glucosamine	0.4	0.5	1.3	1.2	-0.9	0.6	-0.1	-0.6	0.5	0.3
Chronic bronchitis/emphysema (father)	0.4	0.4	1.5	1.2	0.5	0.3	0.3	0.4	0.4	0.9
Leg predicted mass (left)	0.4	2.1	3.2	1.3	0.4	1.7	1.3	-1.4	1.8	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	4.2	-0.7	0.7	0.0	-0.8	0.1	1.1	2.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.5	-0.3	-0.3	1.2	0.1	-0.4	-1.1	-0.7
Alcohol intake versus 10 years previously	0.4	0.5	1.3	0.1	-0.4	-0.6	-1.1	0.1	-0.9	-1.2
Prospective memory result	0.4	0.4	1.6	-0.2	-0.4	0.0	-0.5	-1.3	-0.4	0.9
Tense / ‘highly strung’	0.4	0.7	2.5	1.6	-0.3	1.1	0.4	0.7	-0.0	-0.5
Loud music exposure frequency	0.4	0.4	1.2	-0.1	-0.8	0.9	-0.2	-0.2	0.1	1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.1	-1.2	-0.1	-0.4	-1.3	1.5	-0.4	0.7
Medication: Amlodipine	0.4	0.5	2.6	-0.5	-0.3	0.1	0.7	0.1	0.4	1.6
Worry too long after embarrassment	0.4	0.6	2.4	1.5	-0.4	-0.7	0.5	0.3	-0.5	-1.0
Wheeze or whistling in the chest in last year	0.4	0.7	3.1	-0.2	0.4	0.0	0.8	-1.8	-0.9	0.8
Emphysema/chronic bronchitis	0.4	0.5	2.0	0.7	-0.1	-0.9	-0.4	-0.0	-1.4	-0.0
Medication: Blood pressure	0.4	0.7	2.0	-1.1	-0.1	-1.4	-0.3	-0.6	-0.8	0.7
Suffer from ‘nerves’	0.4	0.6	2.3	1.5	-0.5	-0.1	0.3	0.8	0.6	0.6
Leg fat-free mass (right)	0.4	1.9	3.1	1.2	0.5	1.8	1.3	-1.2	1.8	1.4
Average weekly red wine intake	0.4	0.5	1.8	1.4	0.4	0.3	0.5	-0.8	-0.0	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.8	-0.2	-1.4	0.8	0.3	-0.8	0.3	0.3
Hearing aid user	0.4	0.4	1.1	0.0	-0.2	1.0	0.7	0.5	-1.0	0.2
Mother’s age at death	0.4	0.5	1.3	0.7	-1.1	0.7	-0.2	0.5	1.0	0.7
Bipolar Disorder or Schizophrenia	0.3	0.7	3.3	-0.0	0.1	-1.2	-0.1	0.3	-0.4	-1.8
Depressed Affect (Nagel 2018)	0.3	0.7	2.1	1.5	0.1	0.3	0.6	-0.4	1.0	1.1
Reaction Time	0.3	0.5	1.6	1.3	-0.2	-0.6	0.4	-0.6	0.9	0.4
Breast Cancer	0.3	0.7	1.7	1.3	1.1	-0.2	1.1	0.6	-0.1	-0.7
Age at First Birth	0.3	0.4	1.4	-0.6	0.4	-0.3	-0.6	-1.2	0.6	0.3
Schizophrenia (2014)	0.3	0.7	1.8	-0.0	0.4	-0.4	-1.3	1.2	0.0	-1.2
Blood Red Count	0.3	2.9	5.9	2.0	1.3	0.6	2.0	-1.9	2.4	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.8	-0.2	0.1	-1.3	-0.3	-0.5	-0.4	0.1
Fed-up feelings	0.3	0.6	1.4	1.2	0.4	-0.7	-0.6	0.6	0.6	1.2
Impedance of leg (left)	0.3	1.6	3.9	0.8	1.6	1.0	-1.1	1.3	0.0	-2.0
Number of incorrect matches in round	0.3	0.4	1.0	0.3	0.5	0.4	-0.8	0.9	-1.0	0.0
Had menopause	0.3	0.3	1.7	-0.1	-0.6	0.1	-0.3	-0.1	-0.2	1.3
Impedance of arm (right)	0.3	1.5	2.9	1.6	-0.5	1.6	-1.4	0.2	-0.7	-1.7
Hair/balding pattern: Pattern 3	0.3	0.4	2.0	0.0	0.3	0.4	0.5	-1.4	-0.3	-0.4
Noisy workplace	0.3	0.4	2.0	0.1	0.4	-1.4	-0.3	-0.3	-0.5	-0.2
Impedance of arm (left)	0.3	1.4	4.3	1.8	-0.3	1.0	-0.9	0.3	-0.3	-2.1
Age at first live birth	0.3	0.5	1.5	1.0	0.5	-0.1	-1.2	0.5	0.5	-0.3
Qualifications: College or University degree	0.3	0.9	3.3	1.8	-0.9	-1.2	0.0	0.5	0.6	-0.3
Migraine (self-reported)	0.3	0.4	1.6	0.1	-0.4	-1.0	-1.3	-0.2	0.0	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.2	0.5	1.1	-0.2	-0.5	0.8	0.2	0.6
Number of full sisters	0.3	0.3	1.2	1.1	-0.7	-0.5	0.2	0.5	0.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.8	-0.4	0.2	-0.7	0.3	-0.0	0.1	1.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	2.1	-0.2	-1.4	0.3	-0.0	0.4	-0.0	0.5
Smoking status: Previous	0.3	0.4	1.1	0.8	-0.5	-0.2	1.0	-0.3	0.2	-1.0
Mood swings	0.3	0.5	1.8	1.1	0.1	0.0	1.3	-0.6	-0.5	0.3
Commuting to job workplace: Walk	0.3	0.3	0.8	0.2	-0.8	0.2	0.6	0.9	0.1	-0.5
Breast cancer (self-reported)	0.3	0.3	0.8	-0.7	0.9	-0.2	-0.8	-0.0	0.2	0.4
Leg predicted mass (right)	0.3	1.9	3.0	1.2	0.5	1.7	1.4	-1.2	1.7	1.4
Alcohol drinker status: Never	0.3	0.4	0.7	0.7	-0.5	-0.5	0.4	-0.8	0.5	0.8
Impedance of whole body	0.3	1.7	5.3	1.7	0.6	1.1	-1.0	1.0	-0.3	-2.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.7	0.3	-0.9	-0.0	-0.0	0.7	0.8
Ulcerative Colitis (UC)	0.2	0.3	1.4	-0.2	1.2	0.2	0.4	0.8	-0.3	0.1
Chronotype (morning person)	0.2	0.4	0.8	0.7	-0.4	0.9	0.8	-0.4	-0.2	0.8
Impedance of leg (right)	0.2	1.2	3.2	1.4	1.2	0.7	-0.7	0.9	0.2	-1.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.9	-0.5	-0.0	-0.2	-1.0	-0.1	0.8	0.4
Fluid intelligence score	0.2	0.5	1.2	0.4	-0.3	0.9	-1.1	0.4	0.1	-0.9
Neuroticism score	0.2	0.5	2.4	1.6	-0.7	0.2	0.0	0.3	-0.2	0.5
Falls in the last year	0.2	0.2	0.6	-0.6	0.1	0.2	-0.7	0.5	0.0	0.6
Length of working week for main job	0.2	0.2	0.6	-0.4	0.1	-0.7	0.3	-0.4	0.7	-0.4
Loneliness, isolation	0.2	0.2	1.3	-0.3	1.1	-0.3	0.1	0.4	-0.1	0.3
Unable to work because of sickness or disability	0.2	0.2	0.5	-0.4	0.7	-0.0	0.7	-0.3	0.2	0.1
Crohns Disease (2017)	0.1	0.3	1.3	0.3	0.5	-0.3	0.0	-0.7	0.3	1.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	-0.1	0.9	0.0	0.1	0.3	-0.1	0.8
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	-0.1	0.7	-0.7	-0.2	0.3	-0.0	-0.1
Crohns Disease (2012)	0.1	0.2	0.3	0.4	0.6	-0.3	-0.5	-0.2	0.4	0.3
Neuroticism	0.1	0.2	1.1	1.0	-0.6	0.1	0.2	-0.1	-0.2	0.3
Tanning	0.1	1.7	6.4	1.0	2.5	-0.8	1.3	-1.0	0.1	-1.2
Medication for hormone replacement therapy	0.1	0.1	0.5	0.4	0.1	-0.2	-0.7	0.2	0.1	0.1
Allergy	0.1	0.3	0.8	0.5	0.1	-0.6	-0.9	0.6	-0.2	0.1
Asthma	0.1	0.3	0.9	-0.3	0.6	-0.1	0.2	-0.2	0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.8	-0.0	-0.2	0.1	0.3	-0.9	-0.1	0.0
Mean time to correctly identify matches	0.1	0.3	1.2	-0.0	0.3	0.2	0.0	-1.1	-0.1	0.7
Asthma (self-reported)	0.1	0.2	0.6	-0.1	0.8	-0.1	0.5	-0.1	0.7	0.6
Hair Pigment	0.0	1.0	2.2	1.0	-1.5	0.5	0.8	1.3	0.3	-1.0

Hub : Genes

ST3GAL4

Models

Trait associations