TWAS hub - TIRAP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1770	0.0520	2.8e-04	0.010	NA	0.051	NA	0.022	5.0e-02	NA	4.8e-05	NA	5.7e-03
2	GTEx	Artery Tibial	0.1898	0.0487	7.0e-06	0.009	NA	0.039	NA	0.048	5.7e-02	NA	4.7e-04	NA	1.2e-04
3	GTEx	Brain Cortex	0.4900	0.1080	1.1e-04	0.058	NA	0.069	NA	0.058	1.1e-02	NA	5.7e-03	NA	1.1e-02
4	GTEx	Colon Sigmoid	0.2580	0.0790	1.3e-03	0.035	NA	0.069	NA	0.100	2.1e-02	NA	2.0e-03	NA	2.2e-04
5	GTEx	Colon Transverse	0.2180	0.0690	1.6e-03	0.006	NA	0.091	NA	0.052	1.5e-01	NA	4.0e-05	NA	1.6e-03
6	GTEx	Esophagus Muscularis	0.1390	0.0460	8.7e-04	0.013	NA	0.051	NA	0.036	4.9e-02	NA	4.9e-04	NA	3.0e-03
7	GTEx	Heart Atrial Appendage	0.1380	0.0530	8.1e-03	0.008	NA	0.011	NA	0.016	1.4e-01	NA	9.5e-02	NA	6.1e-02
8	GTEx	Spleen	0.4040	0.1240	4.3e-03	0.004	NA	-0.012	NA	-0.003	2.5e-01	NA	9.3e-01	NA	4.0e-01
9	METSIM	Adipose	0.1083	0.0290	4.4e-06	0.036	0.053	0.024	0.053	0.029	3.2e-06	2.0e-08	1.3e-04	2e-08	3.0e-05
10	ROSMAP	Brain Pre-frontal Cortex	0.2055	0.0349	1.1e-16	0.158	0.157	0.188	0.182	0.188	8.5e-20	9.7e-20	1.2e-23	8e-23	1.3e-23
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0257	0.0145	7.9e-03	0.019	0.007	0.003	NA	0.005	3.0e-03	5.4e-02	1.4e-01	NA	7.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Mouth/teeth dental problems: Mouth ulcers	6.6	10.5	17.6	-3.3	-3.7	-2.6	-1.7	-3.5	-3.5	-3.7	-2.4	-2.1	-3.9	-4.2
Qualifications: CSEs or equivalent	5.9	7.7	11.8	-2.6	-3.4	-3.3	-2.3	-1.7	-2.6	-3.3	-2.2	-1.6	-3.4	-3.3
Bipolar Disorder (2011)	4.5	4.4	12.5	-2.4	-2.2	-1.3	-0.7	-1.4	-1.1	-2.4	-3.5	-2.4	-1.6	-2.5
Exposure to tobacco smoke at home	4.5	5.0	9.8	-2.9	-2.1	-0.9	-2.7	-3.1	-2.8	-2.0	-0.6	-2.0	-2.0	-2.0
Comparative height size at age 10	3.6	20.1	39.6	6.3	4.5	5.0	4.5	4.2	5.1	4.7	2.8	4.5	3.8	3.0
Number of children fathered	3.3	3.7	6.7	-2.6	-1.9	-2.4	-1.7	-1.0	-2.6	-2.1	0.2	-0.8	-1.6	-2.5
Medication: Cholesterol lowering	3.2	4.9	18.3	0.4	1.3	3.0	-0.5	-1.6	-0.4	1.6	4.3	-0.7	1.9	4.0
Wears glasses or contact lenses	3.1	3.5	7.5	-0.9	1.7	1.9	1.4	1.3	0.8	2.0	2.4	2.7	2.4	1.9
LDL Cholesterol	2.9	4.6	16.7	1.8	1.5	2.9	-1.0	-0.7	0.1	1.6	4.1	-0.5	1.6	3.6
Medication: Atenolol	2.8	3.5	7.6	2.5	1.6	1.9	0.7	0.7	0.0	1.9	2.5	1.8	2.2	2.8
Hayfever/allergic rhinitis (self-reported)	2.8	3.7	10.4	-1.0	-1.8	-3.2	-0.2	0.5	-1.0	-1.9	-3.2	0.4	-1.9	-2.5
Medication: Co-codamol	2.7	3.2	7.1	-1.6	-1.6	-1.5	-2.2	-1.6	-2.7	-1.8	0.4	-1.8	-2.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	10.4	-1.8	-1.3	-1.2	-2.2	-2.5	-0.9	-1.4	0.7	-3.2	-1.5	-0.4
Medication: Simvastatin	2.5	3.7	16.5	0.3	0.4	2.3	-1.4	-1.8	-1.4	0.6	4.1	-0.1	0.5	3.2
Breastfed as a baby	2.4	3.0	7.5	-0.4	2.0	1.6	0.8	-0.6	0.8	2.4	2.0	0.7	2.7	2.6
Hair/balding pattern: Pattern 4	2.4	5.9	12.4	2.2	3.2	1.8	1.9	1.8	3.3	3.5	1.4	1.3	2.6	2.3
Birth weight of first child	2.4	4.4	14.2	0.3	3.0	3.8	1.3	-0.6	1.1	2.8	1.4	0.6	2.7	2.1
Peak expiratory flow (PEF)	2.3	5.4	16.6	2.5	1.7	0.5	4.1	3.2	3.4	1.6	-1.1	1.9	2.0	0.3
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	14.8	-0.8	-1.5	-2.4	-0.3	0.4	-0.5	-1.9	-3.8	0.5	-2.1	-3.1
Tinnitus: Yes, now most or all of the time	2.3	2.7	6.4	1.0	1.8	1.5	2.0	0.1	2.5	1.6	0.2	2.4	1.8	0.9
High cholesterol (Self-reported)	2.3	4.0	16.1	0.1	0.8	2.5	-1.4	-1.5	-1.5	1.0	4.0	-0.8	0.4	3.5
Relative age of first facial hair	2.2	4.5	11.8	-2.2	-1.9	-1.3	-3.3	-2.2	-3.4	-2.2	1.2	-1.8	-1.4	-0.7
Medication: Ventolin 100micrograms inhaler	2.2	2.8	6.2	-2.2	-1.4	-1.4	-2.2	-1.4	-2.5	-1.5	0.3	-0.5	-1.6	-2.0
Blood Eosinophil Count	2.1	15.9	52.1	-0.1	-2.9	-5.2	3.5	4.5	1.3	-2.6	-7.2	-0.9	-2.2	-6.4
Standing height	2.1	21.2	50.3	7.1	3.8	5.0	4.2	5.2	5.5	3.8	3.2	4.5	3.7	2.9
Illnesses of father: Heart disease	2.1	2.9	11.6	1.6	0.9	2.4	-0.4	0.2	-0.2	1.2	2.2	1.8	1.3	3.4
Ever taken oral contraceptive pill	2.1	2.3	8.9	-0.2	1.4	0.7	3.0	1.4	2.8	1.7	-0.2	0.1	1.3	0.1
Leg fat percentage (left)	2.1	7.5	18.1	-1.5	-1.8	-1.9	-4.3	-3.1	-4.2	-1.7	3.0	-3.4	-2.1	-0.5
Number of operations (self-reported)	2.1	3.2	6.3	-1.5	-2.3	-2.2	-1.5	-1.1	-1.3	-1.9	0.1	-2.5	-1.7	-2.2
Blood White Count	2.0	14.6	24.5	-3.1	-4.1	-4.9	-4.0	-3.0	-3.8	-3.7	-1.2	-4.9	-5.0	-2.5
Supplements: Vitamin C	2.0	2.4	8.4	-0.4	-1.8	-1.9	-0.3	0.2	-1.1	-1.6	-1.6	-0.4	-2.1	-2.9
Medication: Lisinopril	2.0	2.6	6.0	-0.4	2.4	2.0	0.9	-0.7	1.1	2.3	1.2	0.4	2.1	2.0
Heart attack/myocardial infarction (self-reported)	1.9	2.5	7.8	0.2	-2.8	-1.9	-1.3	-0.5	-1.4	-2.5	0.1	0.2	-2.3	-0.5
Major Depression (MDD)	1.8	2.2	5.2	-1.2	-1.5	-1.0	-1.5	-1.9	-1.1	-1.2	1.2	-2.3	-1.6	-1.3
Heart attack	1.8	2.2	7.1	0.5	-2.7	-1.6	-1.2	-0.4	-1.3	-2.4	0.0	0.1	-2.4	-0.5
Leg fat percentage (right)	1.8	6.4	15.0	-1.6	-1.5	-1.8	-3.9	-3.0	-3.8	-1.4	2.8	-3.3	-1.8	-0.3
Shortness of breath walking on level ground	1.8	2.2	12.1	1.1	1.4	0.8	-0.0	1.2	0.4	1.7	3.5	-0.3	1.3	1.2
Commuting to job workplace: Walk	1.8	2.0	6.5	1.0	1.6	2.5	0.8	1.0	1.8	1.7	0.8	0.1	1.5	1.1
Medication for cholesterol	1.8	2.7	13.2	-1.0	-1.2	-0.7	0.3	-0.4	0.1	-1.7	-3.6	-0.4	-0.9	-3.0
Average weekly spirits intake	1.7	2.1	7.1	-2.7	-1.1	-0.9	-1.4	-1.1	-1.4	-1.1	-0.4	-2.2	-0.9	-1.2
High blood pressure (mother)	1.7	2.4	5.0	2.2	1.4	1.5	1.5	1.4	1.5	2.0	1.7	0.3	1.2	1.4
Diabetes (mother)	1.6	2.0	11.6	-0.6	-0.5	-3.4	1.4	1.1	0.3	-0.4	-2.0	-0.4	-0.8	-1.3
Hearing difficulty/problems with background noise	1.6	2.5	4.9	1.4	1.5	2.2	1.7	0.7	2.2	1.7	2.0	0.5	0.8	1.7
Trunk fat-free mass	1.6	8.9	17.6	4.2	2.8	2.9	2.7	2.4	2.5	2.9	3.2	3.3	3.1	2.5
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	15.3	2.2	2.0	1.3	3.9	2.2	3.0	1.6	-1.7	2.4	2.9	0.7
Ever smoked	1.6	2.7	6.1	0.4	2.5	1.0	1.8	-0.2	2.1	2.2	1.2	1.8	2.0	1.2
Basal cell carcinoma (self-reported)	1.6	1.8	4.3	0.7	1.7	0.1	1.1	0.5	1.2	2.1	1.2	1.2	2.1	1.5
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	7.3	-1.4	-1.4	-1.3	-1.9	-0.6	-2.7	-1.3	0.3	-0.2	-1.2	-1.2
Had other major operations	1.5	1.8	4.5	-1.1	-1.2	-2.1	-1.4	-1.1	-0.8	-1.2	-1.7	-1.4	-1.3	-1.2
Mouth/teeth dental problems	1.5	2.4	9.0	3.0	0.8	1.0	0.9	2.9	2.1	0.5	-0.6	0.9	0.4	0.3
Arm fat percentage (right)	1.5	6.0	16.3	-1.2	-1.8	-1.4	-4.0	-2.4	-3.8	-1.7	2.5	-3.2	-2.0	-0.4
Trunk predicted mass	1.5	8.8	17.1	4.1	2.8	2.8	2.7	2.4	2.5	2.9	3.1	3.3	3.1	2.5
Medication for pain relief, constipation, heartburn	1.5	2.5	4.5	2.0	1.6	1.5	2.0	1.3	1.7	1.4	-0.8	2.1	1.5	-0.4
Height	1.4	27.1	71.4	8.4	3.8	5.9	4.2	7.2	5.5	3.8	3.9	5.5	3.1	2.7
High blood pressure	1.4	4.0	26.0	0.9	1.4	1.1	-1.1	-0.5	-0.7	2.0	5.1	-0.7	1.2	2.5
Sitting height	1.4	10.2	17.3	4.2	3.6	3.3	2.4	2.7	3.3	3.3	2.1	4.2	3.3	2.1
Had menopause	1.4	1.7	6.3	-0.3	1.1	1.7	-0.2	-0.3	-0.1	1.1	2.4	0.2	1.2	2.5
Prospective memory result	1.4	1.7	3.6	0.0	-1.9	-1.1	-1.6	0.1	-1.8	-1.8	-1.0	-0.5	-1.7	-0.9
Body fat percentage	1.4	5.6	15.3	-0.8	-1.5	-1.1	-3.9	-2.1	-3.2	-1.4	3.3	-3.3	-1.9	-0.2
Hand grip strength (left)	1.3	3.4	7.1	1.8	1.8	1.2	2.4	2.1	2.5	1.6	0.2	1.5	2.7	1.1
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.0	-2.0	1.7	0.5	-0.0	-0.8	0.4	1.4	2.0	0.3	1.3	1.5
Mouth/teeth dental problems: Dentures	1.3	2.2	7.2	-1.1	1.3	-1.1	0.9	-1.2	-0.4	1.6	2.7	1.6	1.6	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	10.2	1.9	1.7	1.3	3.2	2.2	2.1	1.1	-2.1	2.2	2.6	0.6
Mouth/teeth dental problems: Loose teeth	1.3	1.5	6.7	-1.3	1.5	0.7	0.8	0.2	0.6	1.7	0.7	0.5	2.6	0.8
Hypertension (Self-reported)	1.3	3.5	23.3	0.9	1.3	0.8	-0.8	0.1	-0.5	2.0	4.8	-0.3	1.1	2.4
Smoking status: Previous	1.3	1.9	4.8	-0.6	2.0	1.0	1.1	-0.7	1.4	1.7	1.3	0.7	2.2	1.6
Illnesses of father: None of the above (group 1)	1.3	1.5	5.9	-1.2	-1.0	-1.4	0.8	0.2	0.4	-1.0	-2.4	-1.3	-0.7	-1.7
Average weekly champagne plus white wine intake	1.3	1.8	5.4	0.9	1.5	1.1	0.7	2.1	2.3	1.3	0.4	0.3	1.6	0.7
Medication: Bendroflumethiazide	1.3	1.9	8.8	0.2	0.9	-0.2	0.3	0.7	-0.2	1.4	3.0	1.3	1.6	2.2
Vascular/heart problems diagnosed by doctor	1.3	3.5	24.5	-1.2	-1.0	-0.4	1.0	0.3	0.9	-1.8	-4.9	0.1	-1.1	-2.4
Lung FEV1/FVC ratio	1.2	5.9	22.1	0.7	2.2	1.3	4.7	3.4	2.7	2.0	-1.6	1.5	2.6	1.1
Number of treatments/medications taken	1.2	2.1	7.5	-1.5	0.6	0.8	-1.3	-1.8	-1.4	1.0	2.7	-0.4	0.2	2.1
Diabetes (father)	1.2	1.5	5.1	0.2	-1.3	-2.2	0.1	1.6	0.2	-1.1	-1.2	0.1	-1.2	-1.8
Medication: Levothyroxine sodium	1.2	2.0	5.3	-1.1	-1.5	-0.1	-1.6	-2.3	-1.8	-1.4	-0.2	-1.9	-1.1	-0.7
Forced vital capacity (FVC)	1.2	4.7	10.3	2.0	2.0	1.3	3.2	1.7	2.6	1.3	-1.8	2.8	3.0	0.4
Illnesses of mother	1.2	1.5	5.0	-1.7	-0.1	1.3	-2.0	-2.2	-1.4	-0.5	0.3	-0.8	0.1	-0.0
Comparative body size at age 10	1.2	3.4	10.8	-0.5	1.3	0.9	-1.7	-2.1	-1.2	1.4	3.3	-2.1	1.6	2.3
Medication: Seretide 50 evohaler	1.2	1.4	3.6	0.3	-0.7	-1.6	-1.9	-1.0	-1.8	-0.8	0.6	-0.3	-1.4	-1.0
Arm predicted mass (right)	1.2	6.0	12.8	3.6	2.1	2.5	1.8	1.5	2.0	2.3	3.6	2.4	2.1	2.3
Arm fat percentage (left)	1.2	4.8	13.2	-0.8	-1.6	-1.1	-3.6	-2.1	-3.1	-1.5	2.6	-2.9	-1.8	-0.1
Schizophrenia (2018)	1.1	2.2	5.0	1.0	1.7	1.1	1.9	2.2	1.6	1.5	-1.8	-0.4	1.7	-0.4
Crohns Disease (2012)	1.1	1.7	3.6	1.5	1.7	1.3	0.9	1.9	1.0	1.7	0.9	0.6	1.7	0.7
Rheumatoid Arthritis	1.1	1.6	6.7	-0.1	-1.2	-1.3	-1.2	0.2	-1.4	-1.2	0.6	-0.8	-2.6	-1.1
Trunk fat percentage	1.1	4.4	13.2	-0.3	-1.2	-0.5	-3.6	-1.4	-2.5	-1.2	3.3	-3.0	-1.9	-0.2
Stomach or abdominal pain in last month	1.1	1.3	3.7	0.6	-1.6	0.1	-1.0	-0.5	-1.4	-1.2	-0.3	-1.9	-1.5	-0.8
Medication: Lansoprazole	1.1	1.3	4.2	-1.7	0.6	-0.4	-1.7	0.1	-1.6	0.5	2.0	-0.7	0.3	0.5
Medication: Paracetamol	1.1	1.8	6.9	-2.6	-0.6	-1.0	-1.7	-1.7	-1.8	-0.6	1.2	-1.0	-0.2	0.4
Arm fat-free mass (right)	1.1	5.4	12.6	3.5	1.9	2.1	1.7	1.6	1.9	2.1	3.5	2.5	1.9	2.0
Wheeze or whistling in the chest in last year	1.1	1.9	6.9	-1.4	-1.1	-2.6	-0.1	0.6	-1.3	-0.7	0.3	-1.1	-1.6	-2.1
Chest pain or discomfort	1.1	1.6	9.2	0.3	0.6	1.7	-0.6	-0.5	-0.3	1.1	3.0	-0.2	0.7	1.7
Whole body fat-free mass	1.1	6.5	15.8	4.0	2.2	2.2	1.9	1.9	2.0	2.3	3.5	2.7	2.2	2.1
Ever had bowel cancer screening	1.1	1.3	4.0	-0.6	1.3	1.0	-0.6	-0.8	0.4	1.2	1.2	-0.4	1.7	2.0
Whole body water mass	1.1	6.5	15.6	4.0	2.1	2.2	2.0	1.9	1.9	2.3	3.5	2.8	2.2	2.1
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.9	-0.7	-1.2	-1.5	-0.1	0.4	-0.5	-1.4	-2.2	0.7	-1.1	-1.5
Arm predicted mass (left)	1.1	5.3	14.6	3.5	2.0	2.2	1.4	0.9	1.1	2.2	3.8	2.2	2.0	2.3
Bipolar Disorder (2018)	1.0	1.5	6.9	-0.9	-1.5	-0.6	-0.1	0.1	0.3	-1.4	-2.6	-0.6	-1.2	-1.6
Age at First Birth	1.0	1.5	3.6	-0.5	-1.9	-0.2	-1.3	-1.2	-1.6	-1.6	-0.7	-1.1	-1.6	-0.6
HDL Cholesterol	1.0	1.7	6.2	-1.7	-1.0	-1.0	0.2	0.6	-0.0	-1.2	-2.1	-0.3	-1.1	-2.5
Cardiovascular Disease	1.0	3.5	13.2	1.3	1.9	2.1	0.4	0.2	0.4	2.3	3.6	0.4	1.3	2.7
Ever used hormone-replacement therapy (HRT)	1.0	1.2	7.2	-2.7	-0.8	-1.0	-0.6	-0.8	-1.0	-0.5	0.3	-1.3	-0.7	-0.4
Ever had hysterectomy (womb removed)	1.0	1.2	3.0	-0.6	1.1	1.5	-0.3	-1.7	0.1	0.8	1.6	-0.6	1.0	1.2
Systolic blood pressure, automated reading	1.0	3.0	15.7	0.1	1.1	0.6	-1.5	0.4	-1.9	1.1	4.0	1.9	1.2	1.8
Hand grip strength (right)	1.0	2.7	7.6	2.2	0.9	0.6	2.5	2.4	2.8	0.7	-0.1	0.8	1.6	0.8
Townsend deprivation index at recruitment	1.0	1.4	5.1	-0.4	1.2	1.0	-0.8	-0.9	-0.1	0.9	2.3	-1.4	0.8	1.5
Taking other prescription medications	1.0	1.5	3.8	-1.2	-0.4	-1.2	-1.2	-1.9	-1.9	-0.1	1.6	-0.8	-1.2	0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	5.9	1.7	1.7	2.4	0.4	-0.5	0.5	1.7	1.8	1.2	1.9	1.5
Heart disease (mother)	1.0	1.2	2.3	0.7	-1.5	0.0	-1.2	-0.5	-1.5	-1.3	1.1	-1.4	-1.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.3	4.2	1.2	1.2	0.7	-0.2	0.9	0.2	1.2	2.0	-0.3	0.9	1.7
Average weekly red wine intake	1.0	1.5	3.3	-0.2	-1.6	-0.5	-0.8	0.2	-0.2	-1.6	-1.8	-1.4	-1.7	-1.5
Mood swings	1.0	1.9	5.8	-0.6	-1.4	-2.1	0.2	1.3	-0.6	-1.3	-0.4	-1.1	-1.8	-2.4
Eye problems/disorders: Glaucoma	1.0	1.2	3.4	-0.9	-0.8	-0.1	0.6	1.6	-0.3	-0.8	-1.8	-1.7	-1.0	-0.9
Medication: Blood pressure	1.0	1.9	11.9	0.5	0.7	-0.5	-1.1	0.7	-1.1	1.2	3.4	0.4	0.6	1.8
Medication: Paracetamol	1.0	1.6	6.1	-2.5	0.3	0.0	-1.0	-0.8	-1.2	0.5	2.4	-0.1	0.6	1.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.4	-1.0	-0.8	-0.6	-1.1	-1.8	-0.6	-0.7	0.6	-1.8	-1.2	-1.0
Leg fat mass (left)	1.0	3.7	13.4	0.2	-1.0	-0.6	-3.0	-1.9	-2.7	-0.8	3.7	-2.0	-1.3	0.3
Lupus	0.9	1.3	6.5	-0.8	-0.6	-0.2	0.2	0.2	0.4	-1.0	-2.5	0.8	0.0	-2.2
Waist Hip Ratio (WHR)	0.9	4.2	9.9	0.6	-2.4	-3.1	-0.6	1.1	-0.9	-2.6	-2.2	-1.8	-3.0	-2.1
Hypothyroidism (self reported)	0.9	2.0	8.6	0.1	-1.1	-0.2	-1.5	-2.9	-1.5	-1.1	0.1	-2.2	-1.0	-0.3
Relative age voice broke	0.9	1.4	2.2	-1.3	-1.2	-0.8	-1.1	-0.5	-1.2	-1.4	-1.4	-1.0	-1.3	-1.5
Supplements: Glucosamine	0.9	1.1	3.3	1.3	0.9	0.4	0.1	1.4	0.6	0.7	1.8	0.6	1.2	1.3
Body mass index (BMI)	0.9	4.0	10.0	-1.0	-1.2	-1.1	-3.0	-2.5	-3.2	-1.0	2.9	-2.0	-1.4	0.1
Past tobacco smoking	0.9	1.7	3.3	0.5	-1.8	-0.7	-1.4	0.7	-1.6	-1.6	-1.1	-1.3	-1.8	-1.1
Glaucoma (self-reported)	0.9	1.1	3.7	-0.7	-0.7	0.4	0.4	1.7	-0.2	-0.8	-1.9	-1.6	-0.7	-0.7
Gout (self-reported)	0.9	1.3	5.0	0.6	-0.4	0.2	-0.7	-2.2	-0.4	-0.2	1.4	-1.7	0.8	1.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	6.1	-0.7	-1.4	-0.2	-1.3	-2.5	-1.4	-1.3	-0.6	-1.8	-1.2	-0.8
Forced vital capacity (FVC), Best measure	0.9	3.3	6.6	1.9	1.7	1.4	2.4	1.5	2.1	1.0	-1.9	2.0	2.6	0.4
Leg fat mass (right)	0.9	3.5	12.0	0.2	-0.9	-0.6	-2.9	-1.8	-2.7	-0.7	3.5	-2.1	-1.2	0.4
Leg pain on walking	0.9	1.1	4.2	-1.5	-0.5	-2.0	-0.8	0.1	-1.5	-0.3	0.5	-0.5	-0.9	-1.0
Medication: Aspirin	0.9	1.2	5.8	1.2	0.8	-0.4	-0.0	-0.2	0.8	1.0	1.6	-0.1	1.0	2.4
Basal metabolic rate	0.9	4.8	13.7	3.6	1.7	1.9	1.2	1.5	1.4	1.9	3.7	2.0	1.7	1.9
Arm fat-free mass (left)	0.9	4.8	13.2	3.3	1.8	2.0	1.3	1.1	1.2	2.0	3.6	2.1	1.8	2.1
Alcohol drinker status: Previous	0.9	1.0	3.1	-1.8	0.6	0.6	-1.2	-1.2	-1.0	0.3	1.4	-0.5	-0.1	0.6
Blood Platelet Count	0.8	8.8	34.1	-2.0	-3.2	-1.7	-1.9	1.3	-0.3	-2.6	5.8	-2.2	-5.2	-0.9
Systolic Blood Pressure	0.8	3.8	10.8	0.6	1.9	1.6	-0.7	1.1	-0.7	1.7	3.3	2.5	2.7	2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	5.2	0.7	1.4	2.3	-0.1	-1.5	0.2	1.4	2.2	0.6	1.3	1.3
Medication: Ramipril	0.8	1.0	2.6	1.6	-1.1	-1.2	-0.7	1.1	-0.6	-0.9	0.3	-0.8	-1.4	-0.9
Neuroticism score	0.8	1.6	4.2	0.0	-1.0	-1.6	-0.3	1.8	-0.4	-0.8	0.3	-2.1	-1.5	-1.9
Depression (self-reported)	0.8	0.9	3.7	-1.7	-0.5	-0.7	-0.8	1.1	-0.6	-0.6	-0.1	-1.9	-0.5	-0.4
Pulse wave Arterial Stiffness index	0.8	0.9	2.5	1.6	0.3	0.2	0.2	0.8	1.0	0.6	1.3	1.2	-0.2	1.6
Arm fat mass (right)	0.8	3.2	12.2	0.1	-0.8	-0.2	-2.8	-1.6	-2.5	-0.6	3.5	-2.1	-1.0	0.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.6	-0.8	-1.2	0.2	-1.1	-0.4	-1.0	-1.4	-0.5	-1.9	-0.9	-0.7
Medication: Omeprazole	0.8	1.0	3.4	-1.3	-0.5	-0.5	-1.1	-1.9	-0.4	-0.4	0.6	-1.4	-0.9	-0.9
Had major operations	0.8	1.0	2.4	-0.2	-1.5	-0.6	-1.1	-0.8	-0.5	-1.1	0.4	-1.5	-1.4	-0.7
Age at last live birth	0.8	1.1	3.0	0.1	-1.1	0.3	-0.8	-0.0	-1.0	-1.3	-1.6	-1.7	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	8.9	-1.1	-0.8	0.2	0.1	-0.6	-1.4	-1.3	-3.0	-0.7	-0.1	-1.5
Number of self-reported non-cancer illnesses	0.8	1.4	4.0	-0.9	-0.7	-0.8	-1.5	-1.4	-2.0	-0.2	2.0	-0.1	-1.3	-0.0
Financial situation satisfaction	0.8	1.0	2.6	0.7	1.1	1.6	1.2	0.8	1.4	1.1	1.4	-0.1	0.0	0.4
Ever depressed for a whole week	0.8	0.9	4.0	-1.3	0.6	0.9	-1.0	-1.0	-0.5	0.3	0.3	-2.0	0.3	1.0
Bipolar Disorder or Schizophrenia	0.7	1.7	9.2	0.1	0.4	0.4	1.4	1.8	1.4	0.2	-3.0	-0.7	0.5	-1.3
Primary Biliary Cirrhosis	0.7	1.0	4.3	-0.3	-1.3	-1.2	0.7	0.2	-0.3	-1.0	-2.1	0.5	-0.6	-1.0
BMI	0.7	4.0	11.6	-0.8	-1.1	-1.4	-3.4	-2.1	-3.0	-1.1	2.6	-2.2	-1.4	-0.1
Leg fat-free mass (left)	0.7	3.5	11.9	3.4	1.2	1.1	0.9	1.4	1.2	1.4	3.3	1.8	1.0	1.3
Chronic bronchitis/emphysema (father)	0.7	0.8	3.6	-0.5	-1.1	-0.6	-0.4	-0.1	-0.3	-0.8	1.2	-0.3	-1.9	-1.0
Leg predicted mass (left)	0.7	3.5	12.6	3.5	1.2	1.1	0.9	1.4	1.2	1.4	3.4	1.8	0.9	1.3
Number of incorrect matches in round	0.7	1.2	3.3	0.5	-1.3	0.1	-1.6	-0.4	-0.8	-1.0	-0.0	-1.8	-1.8	0.1
Allergy	0.7	1.6	5.0	2.2	0.2	1.9	0.0	-0.3	0.3	0.2	1.1	-1.5	0.6	2.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.3	-0.8	-0.8	-1.5	-0.2	1.2	-0.4	-0.6	0.1	-0.7	-1.1	-1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.0	0.9	0.9	1.3	0.9	0.3	1.0	0.9	-0.3	1.5	1.7	0.8
Medication: Amlodipine	0.7	0.9	2.7	0.5	0.3	0.5	0.4	1.6	0.1	0.7	1.6	1.2	0.6	1.4
Medication: Blood pressure	0.7	1.2	2.9	-0.1	1.1	1.4	0.7	-0.2	0.5	1.5	1.7	-0.4	1.3	1.6
Migraine (self-reported)	0.7	0.9	3.8	0.8	-0.4	0.6	-0.7	0.0	-0.1	-0.7	-0.7	-1.9	-1.5	-0.8
Whole body fat mass	0.7	2.7	15.0	0.6	-0.4	-0.1	-2.5	-1.0	-1.9	-0.2	3.9	-1.6	-0.8	0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	-0.9	-1.4	-1.0	-0.1	-0.7	-1.0	-1.3	-0.4	1.0	-0.6	-0.9
Arm fat mass (left)	0.7	2.8	12.2	0.5	-0.7	-0.1	-2.6	-1.4	-2.2	-0.5	3.5	-1.6	-0.9	0.7
Miserableness	0.7	1.2	6.0	0.8	-0.7	-1.6	0.3	2.4	0.2	-0.7	1.1	-0.8	-0.7	-1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	4.4	2.1	0.4	0.6	0.5	-0.1	0.6	0.7	1.4	1.1	-0.1	0.3
Unable to work because of sickness or disability	0.7	0.9	2.1	1.0	1.1	0.4	1.2	1.0	1.4	1.2	0.2	1.1	0.4	0.0
Supplements: Calcium	0.7	0.8	1.9	-0.3	-0.9	0.4	-1.1	-0.6	-1.1	-0.9	-0.9	-1.4	-1.1	0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	3.2	0.7	-0.1	0.7	-0.9	1.1	-0.8	-0.4	0.2	-1.8	-0.7	-0.9
Crohns Disease (2017)	0.6	1.3	4.6	0.5	1.1	1.0	0.4	1.8	0.4	1.0	2.1	0.5	1.3	0.7
Coronary Artery Disease (CAD)	0.6	0.7	2.8	-0.2	-0.1	1.4	-0.9	-0.6	-1.7	-0.1	1.0	-0.2	-0.3	1.0
Triglycerides	0.6	1.0	3.4	1.9	0.7	-0.7	0.8	1.3	0.4	1.1	1.2	0.6	0.7	0.9
Ulcerative Colitis	0.6	0.8	5.5	-1.0	-0.6	0.6	0.3	0.5	0.2	-1.0	-2.3	-0.4	-0.2	-0.2
Allergy or Eczema	0.6	1.5	5.3	-0.1	1.0	-0.9	1.4	1.4	1.1	0.8	-1.2	2.3	0.9	-1.0
Pack years adult smoking proportion	0.6	1.0	4.2	-0.2	-0.4	0.1	1.2	0.8	0.6	-0.6	-2.0	0.9	-1.0	-1.3
Age when periods started (menarche)	0.6	1.4	3.7	1.1	0.1	0.5	1.8	1.9	1.7	0.1	-1.4	1.3	0.1	-0.7
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.9	-1.2	0.6	-1.2	0.8	0.6	0.6	0.4	-1.4	2.2	0.5	-1.5
Multivitamins +/- minerals	0.6	0.7	3.6	-0.3	0.7	1.9	0.5	-0.2	0.7	0.3	-1.3	0.9	0.8	0.0
Trunk fat mass	0.6	2.7	14.8	0.9	-0.4	0.3	-2.5	-0.6	-1.6	-0.3	3.9	-1.9	-0.9	0.5
Waist circumference	0.6	2.1	10.4	0.6	-0.6	-0.5	-2.1	-0.5	-2.0	-0.5	3.2	-1.4	-0.9	0.3
Pain all over the body in last month	0.6	0.6	1.6	-0.2	1.0	0.3	0.4	-0.7	0.6	0.8	0.3	0.8	1.3	1.1
Hip circumference	0.6	2.6	16.5	1.0	0.2	1.1	-1.9	-1.1	-1.7	0.4	4.1	-0.5	0.1	1.2
Alcohol intake versus 10 years previously	0.6	0.9	2.0	0.6	-0.9	-1.3	-1.1	0.4	-0.7	-0.8	1.3	0.7	-1.4	-0.9
Tense / ‘highly strung’	0.6	1.0	2.2	-1.1	-0.9	-0.9	-0.6	1.1	0.2	-0.8	-0.4	-1.4	-1.2	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.3	-1.8	-0.3	-0.2	-0.8	-0.4	-0.8	-0.1	1.4	-1.1	-1.2	-0.1
Exposure to tobacco smoke outside home	0.6	0.8	3.3	0.3	-0.3	0.8	-0.9	-0.0	-1.3	0.0	1.8	-1.2	-0.7	0.1
Medication: Allopurinol	0.6	0.8	2.6	0.6	-0.3	0.5	-0.4	-1.5	-0.1	-0.1	1.3	-1.2	0.4	1.6
Alcohol intake frequency.	0.6	1.4	4.9	-0.5	-0.6	-0.7	-1.6	-0.3	-1.3	-0.6	2.2	-1.7	-1.4	0.3
Suffer from ‘nerves’	0.6	0.9	2.7	-1.2	-0.3	-1.4	-0.6	1.3	-0.5	-0.3	-0.4	-0.7	-0.8	-1.6
Overall health rating	0.6	1.2	4.1	-1.2	0.2	0.6	-1.5	-1.1	-2.0	0.2	1.7	-1.1	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.7	2.0	0.8	2.2	0.8	0.9	1.2	0.6	0.5	0.9	0.6	0.2
Leg fat-free mass (right)	0.6	3.1	12.0	3.5	0.9	1.0	0.8	1.4	1.2	1.1	3.2	1.8	0.7	1.0
Breast cancer (self-reported)	0.6	0.7	2.2	-0.4	-0.2	1.5	-1.0	-1.3	-0.4	-0.3	0.6	-1.1	-0.1	0.9
Smoking status: Current	0.6	1.0	4.3	0.1	-0.6	-1.1	0.1	0.4	-0.4	-0.8	-1.2	0.9	-1.3	-2.1
Leg predicted mass (right)	0.6	3.1	12.0	3.5	0.9	1.0	0.9	1.4	1.2	1.1	3.2	1.8	0.7	1.1
Guilty feelings	0.6	0.9	4.9	-0.3	-0.5	-2.2	-0.0	0.2	-0.4	-0.4	-0.4	-0.2	-0.6	-1.8
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.0	-1.4	-0.8	-0.8	-0.7	1.3	-0.9	-0.7	1.2	0.2	-0.1	0.3
Illnesses of father: High blood pressure	0.6	0.7	5.1	0.6	0.6	0.4	-0.7	-0.8	-0.2	0.3	2.3	0.1	-0.1	0.5
Alcohol drinker status: Never	0.6	0.8	2.3	1.5	-0.7	-1.1	0.5	1.1	0.8	-0.5	-0.4	-1.1	-0.7	-0.3
Diastolic blood pressure, automated reading	0.6	1.7	11.2	0.5	0.9	1.1	-1.0	0.4	-1.0	1.0	3.3	-0.3	0.6	1.4
Alzheimer’s Disease (in mother)	0.5	0.6	2.4	-1.2	-0.2	-1.5	0.3	-0.2	-0.1	-0.3	-0.5	0.5	-0.4	-1.5
Prostate Cancer	0.5	0.8	1.6	-0.5	-1.2	-1.2	0.5	0.9	-0.3	-1.0	-0.8	-0.2	-0.9	-1.3
Fasting Glucose	0.5	0.6	2.3	0.5	0.2	0.4	1.5	0.4	0.9	0.1	0.0	1.5	0.6	0.3
Schizophrenia (2014)	0.5	1.1	5.3	0.2	0.6	0.8	0.8	1.5	0.4	0.4	-2.3	-1.1	0.1	-1.3
Lung FVC	0.5	2.7	8.9	-0.6	0.1	-1.6	2.1	0.8	0.5	-0.3	-3.0	2.6	2.3	-0.5
Chronotype (morning person)	0.5	1.2	4.2	-0.4	-1.1	-0.6	-0.8	0.1	-2.1	-1.4	-0.0	1.2	-1.4	-0.9
Current tobacco smoking	0.5	0.8	4.2	-0.2	-0.5	-1.1	0.1	0.1	-0.5	-0.6	-1.1	0.7	-1.1	-2.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-0.3	1.2	0.2	0.6	-0.4	0.2	1.1	0.9	-0.7	1.3	0.4
Diabetes (self-reported)	0.5	0.8	3.6	0.4	-0.2	0.5	0.7	0.1	1.0	-0.3	-1.2	-1.9	-0.2	-1.3
Fluid intelligence score	0.5	1.1	3.6	-0.8	1.7	-0.0	0.3	-0.5	0.9	1.5	0.1	-0.4	1.9	1.1
Weight	0.5	2.5	17.1	2.2	0.5	1.1	-1.0	-0.1	-0.6	0.7	4.1	-0.0	0.3	1.3
Pulse rate	0.5	0.8	2.0	-0.2	0.3	-1.2	1.4	1.3	1.1	0.7	-1.2	0.9	0.1	-0.1
Happiness	0.5	0.6	3.5	-0.0	-0.8	-0.2	0.1	0.3	0.6	-0.7	-0.3	-1.9	-1.2	-0.4
Noisy workplace	0.5	0.6	1.5	-0.2	-0.9	0.2	-0.6	-0.6	-0.9	-0.8	-0.0	-0.7	-1.1	-1.2
Pulse wave reflection index	0.5	0.7	1.8	0.2	0.4	1.1	0.0	1.1	0.7	0.4	1.3	0.8	0.4	1.2
Loud music exposure frequency	0.5	0.5	1.8	-0.5	0.1	0.2	-0.5	-1.3	-0.8	-0.0	1.2	1.2	0.2	0.2
Number of full brothers	0.5	0.6	1.3	-0.9	-0.9	0.2	0.2	0.9	-0.5	-0.9	-0.7	-0.6	-1.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.1	-1.1	-0.4	-0.2	0.1	-0.6	0.4	-0.6	-1.8	-0.9	0.4	-0.7
Pulse wave peak to peak time	0.5	0.5	1.5	-1.1	0.1	0.3	0.0	-0.6	-0.7	-0.2	-1.0	-0.8	0.7	-1.2
Health satisfaction	0.5	0.7	1.6	-0.4	1.0	-1.1	-0.0	0.7	-0.4	1.3	1.1	-0.9	0.2	-0.7
Mean time to correctly identify matches	0.5	0.9	3.1	0.8	0.8	0.7	-0.2	1.8	0.0	0.9	1.1	0.5	0.8	1.4
Pulse rate, automated reading	0.5	1.7	4.0	1.7	1.4	-0.1	2.0	1.7	1.5	1.9	-0.1	0.7	0.2	0.6
Number of full sisters	0.5	0.7	1.6	-0.1	-1.3	-0.4	-0.2	-0.7	-0.7	-1.1	-0.8	-0.3	-1.3	-0.8
Family relationship satisfaction	0.5	0.6	1.7	1.3	0.3	1.2	0.9	0.0	1.3	0.3	-0.2	-0.8	0.2	0.1
Illnesses of siblings: Diabetes	0.5	0.6	1.6	-0.7	-0.9	-0.8	-1.2	0.8	-0.5	-0.9	0.4	-0.0	-1.1	-0.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.4	-0.3	0.5	-1.5	0.8	1.3	0.1	0.7	-0.0	0.3	0.8	0.2
Qualifications: nursing, teaching	0.5	0.7	4.0	0.9	-0.0	1.1	-0.5	-0.7	0.8	-0.0	0.1	-2.0	0.6	0.1
Medication: Aspirin	0.5	0.7	2.8	1.0	0.4	-0.5	-0.3	-0.3	0.2	0.6	1.4	-0.4	0.6	1.7
Mother’s age at death	0.5	0.6	3.3	1.8	0.5	-0.0	0.2	0.5	0.6	0.6	-0.8	0.1	0.9	1.0
Fractured/broken bones in last 5 years	0.5	0.7	2.9	-0.0	0.9	0.6	-0.1	0.6	0.6	0.4	0.2	1.7	1.4	0.6
Cholesterol lowering medication	0.5	0.8	2.5	1.5	-0.2	0.2	-0.5	0.0	-0.9	0.1	1.6	0.1	-0.8	1.5
Heart disease (siblings)	0.5	0.6	1.3	-0.8	-1.1	0.6	-1.1	-0.3	-1.1	-1.1	0.6	-0.4	-0.5	0.4
Depressed Affect (Nagel 2018)	0.4	0.7	3.0	0.2	-0.1	-0.9	0.1	1.5	-0.3	0.2	1.7	-1.4	0.1	0.0
Alzheimer’s Disease (in father)	0.4	0.5	1.5	-0.2	0.1	-0.2	-1.2	-0.4	-1.2	-0.1	1.2	-0.6	0.0	0.0
HbA1C	0.4	0.5	2.8	-0.8	-0.2	-1.7	-0.5	-0.5	-0.5	-0.2	0.3	-0.5	0.0	-0.6
Neuroticism (2016)	0.4	0.6	3.7	-0.2	-0.2	0.3	-0.5	1.9	-0.2	-0.2	0.5	-1.0	-0.4	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.3	-0.9	-0.3	-0.6	0.5	-0.7	-0.0	-0.4	-1.1	-0.7	-0.6	-1.1
Heel T-Score	0.4	3.0	10.9	1.0	0.8	3.3	-0.6	-1.8	-0.0	0.8	2.9	-1.0	1.1	2.4
Respiratory disease	0.4	0.9	2.2	-0.3	1.1	-1.1	0.9	1.5	0.9	1.2	0.4	-0.2	-0.0	-1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.9	1.4	-0.1	-0.4	0.8	0.7	0.9	-0.0	-0.9	-1.3	-0.0	-1.1
Medication for hormone replacement therapy	0.4	0.4	1.2	-1.1	0.1	0.2	-0.3	-1.1	-0.1	0.3	1.0	-0.8	0.4	0.2
Vitamin and mineral supplements	0.4	0.6	1.7	1.3	-0.0	-1.1	0.4	0.8	0.4	0.3	1.2	-0.4	0.3	1.0
Supplements: Zinc	0.4	0.4	2.3	0.3	0.2	1.5	-0.3	-0.7	0.0	0.1	-0.5	0.9	0.2	0.5
Severe depression (siblings)	0.4	0.4	1.5	-1.0	0.1	-0.2	-0.2	0.4	-1.1	-0.3	0.1	1.2	0.6	-0.6
Fed-up feelings	0.4	0.8	4.7	-0.2	-0.5	0.1	-0.5	1.1	-0.7	-0.3	1.1	-2.2	-0.5	-0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.8	-0.4	0.2	-0.6	0.7	-0.1	-0.4	0.8	-1.1	-0.3	-0.7
Serious illness, injury or assault to yourself	0.4	0.5	2.1	-1.3	-0.2	0.1	-0.2	-1.5	-0.8	-0.1	-0.1	-0.1	0.1	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	-0.3	0.6	0.8	0.1	-0.2	-0.2	0.4	0.7	1.1	0.8	1.1
Nervous feelings	0.4	0.7	3.6	0.4	-0.4	0.6	-0.3	0.7	0.0	-0.4	-0.3	-1.9	-1.0	-1.4
Hair/balding pattern: Pattern 2	0.4	0.5	2.0	-0.9	-0.3	-0.6	0.5	0.1	0.0	-0.4	-1.4	-0.7	-0.7	-1.1
Illnesses of siblings	0.4	0.5	2.2	-0.9	0.7	0.5	0.6	-0.4	0.7	0.3	-1.5	-0.3	0.1	-1.1
Father’s age at death	0.4	0.5	1.1	0.9	0.6	0.1	0.6	-0.5	0.9	1.1	0.0	-0.7	0.3	0.8
Qualifications: A levels/AS levels or equivalent	0.4	1.0	3.4	-0.1	0.4	0.6	1.4	0.4	1.8	0.7	-0.5	0.4	1.8	-0.4
Asthma	0.4	0.8	2.6	-0.6	0.3	-1.5	0.5	1.0	0.1	0.7	0.8	-0.6	-0.5	-1.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.5	-1.2	-0.3	-1.1	-0.5	0.7	-0.7	-0.4	0.7	-0.3	-0.4	0.2
Birth weight	0.4	0.8	2.3	0.3	1.2	0.6	1.0	0.5	1.5	0.9	-0.0	1.1	1.0	0.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	3.2	0.3	-0.9	-0.0	0.6	0.2	0.4	-0.7	-1.8	-0.3	-0.4	-0.3
Worry too long after embarrassment	0.4	0.6	1.5	0.6	-0.3	0.2	0.7	0.9	1.1	-0.2	-1.0	-0.9	-0.9	-1.2
Emphysema/chronic bronchitis	0.4	0.5	1.4	-0.1	-0.3	1.2	-1.1	0.2	-0.9	-0.1	1.1	-0.3	-0.6	-0.6
Medication: Ibuprofen	0.4	0.4	2.0	-0.9	-0.5	-0.7	0.3	1.4	0.2	-0.2	0.4	-0.3	-0.7	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	-0.6	0.5	-0.0	1.0	0.9	1.1	0.5	0.4	-0.3	0.1	0.3
Asthma (self-reported)	0.4	0.8	3.3	-0.7	0.0	-1.6	0.5	1.0	0.1	0.5	0.6	-0.5	-0.7	-1.8
Osteoporosis (self-reported)	0.4	0.5	1.6	-1.3	-0.2	0.5	-1.0	-0.7	-0.7	-0.2	0.7	0.0	-0.2	-0.7
Osteoarthritis (self-reported)	0.4	0.6	1.8	-0.8	0.3	-0.9	0.3	-1.3	-0.6	0.5	1.4	0.0	0.3	0.7
Medication: Gliclazide	0.4	0.4	1.4	1.1	-0.6	-0.1	1.2	0.8	0.6	-0.1	-0.4	-0.6	-0.4	-0.5
Commuting to job workplace: Public transport	0.4	0.5	1.3	0.7	1.0	0.6	0.2	0.5	0.7	0.8	-0.2	-0.1	1.0	1.1
Medication: Atorvastatin	0.4	0.5	1.9	1.2	0.2	0.4	0.4	-0.2	0.2	0.4	1.1	-0.7	0.7	1.4
Average weekly beer plus cider intake	0.4	0.6	3.1	-0.2	-0.7	0.2	-1.0	-1.1	-1.8	-0.8	0.1	-0.6	0.0	0.1
Commuting to job workplace: Cycle	0.4	0.5	1.5	-0.3	-0.2	-1.0	0.8	0.3	1.0	-0.5	-1.2	0.5	0.8	0.4
Myopia	0.4	0.6	1.9	-0.0	0.2	0.8	-0.0	-0.9	0.1	0.5	1.4	-0.9	0.2	1.2
Pack years of smoking	0.4	0.7	2.0	0.0	-0.1	0.2	1.3	0.7	0.7	-0.2	-1.3	1.4	-0.6	-0.7
Neuroticism (Nagel 2018)	0.3	0.7	2.4	0.2	0.1	-0.6	0.4	1.4	0.4	0.6	1.4	-1.5	-0.3	-0.1
Worry (Nagel 2018)	0.3	0.6	2.5	-0.3	-0.3	-0.6	-0.3	1.6	-0.1	-0.1	0.3	-1.5	-0.6	-0.7
Ulcerative Colitis (UC)	0.3	0.6	1.5	-0.8	-0.7	-0.7	-0.3	0.6	-0.3	-1.2	-1.2	0.2	-0.7	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.7	0.4	1.3	-0.6	0.7	0.4	1.3	1.3	-0.1	-0.0	1.3	0.6
Breast Cancer	0.3	0.8	3.4	0.3	0.5	1.8	1.0	-0.6	1.9	0.7	0.3	0.1	-0.3	0.2
Body Mass Index (BMI) (2010)	0.3	0.4	3.7	-0.3	-0.2	-0.5	-0.4	0.3	0.3	-0.3	1.9	-0.5	-0.3	0.3
Mean Putamen Volume	0.3	0.3	1.6	1.2	-0.6	-0.4	-0.2	0.6	0.4	-0.4	-0.3	-0.4	-0.3	-0.6
Smoking Status	0.3	0.8	2.9	-0.2	0.9	-0.1	1.6	-0.0	1.1	0.6	-0.1	1.7	1.0	-0.3
Neuroticism	0.3	0.8	3.2	0.0	-0.1	-1.1	-0.0	1.8	-0.1	0.2	1.3	-1.3	-0.6	-0.6
Hearing difficulty/problems: Yes	0.3	0.4	2.9	0.9	-0.3	1.7	-0.2	-0.5	0.8	-0.2	0.2	0.1	-0.1	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	0.6	-0.4	0.8	-0.5	-0.9	-0.4	-0.4	0.9	-0.6	-0.3	0.4
Angina	0.3	0.4	2.6	0.7	0.3	-0.3	-0.4	0.5	-0.5	0.5	1.6	0.3	0.3	0.5
Medication: Metformin	0.3	0.4	1.4	1.2	-0.4	-0.3	0.2	0.8	0.3	-0.2	-0.7	-1.0	-0.6	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	2.7	-0.0	-0.2	0.1	0.2	0.6	-0.1	0.2	1.6	-0.3	-0.7	0.1
Financial difficulties in last 2 years	0.3	0.4	1.8	-0.1	0.0	-1.3	0.8	0.4	0.5	-0.1	0.1	1.0	0.5	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	2.5	-1.6	0.0	0.1	-0.0	-1.1	-0.4	0.2	1.3	-0.8	-0.1	-0.4
Lung cancer (father)	0.3	0.4	1.0	0.0	0.7	0.5	0.8	0.1	-0.0	0.8	-0.4	1.0	0.8	0.2
Headache pain in last month	0.3	0.5	1.4	0.6	-0.5	-1.2	0.0	0.9	-0.1	-0.2	0.8	-0.8	-0.9	0.3
Age at first live birth	0.3	0.6	4.5	0.4	-0.4	0.4	-0.5	0.4	-0.4	-0.5	-2.1	-0.4	-0.4	-0.0
Neck or shoulder pain in last month	0.3	0.5	1.3	0.6	-0.1	-0.9	0.4	1.1	0.4	-0.1	0.5	0.8	-0.7	-1.1
Angina (self-reported)	0.3	0.3	1.6	0.2	-0.0	-0.9	-0.4	0.4	-0.7	0.2	1.2	0.4	0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.4	0.5	-0.9	-0.0	-0.4	-0.4	0.1	-0.7	0.4	-0.4	-1.2	0.1
Long-standing illness, disability or infirmity	0.3	0.4	1.8	-0.5	1.0	0.4	-0.2	-0.0	-0.1	1.0	1.4	0.3	0.4	0.5
Diabetes diagnosed by doctor	0.3	0.5	1.4	1.1	-0.3	0.4	0.4	0.0	0.6	-0.2	-1.0	-1.2	-0.0	-0.7
Eye problems/disorders: Cataract	0.3	0.3	0.9	0.6	-0.3	-0.3	0.3	1.0	0.8	-0.4	-0.0	0.7	-0.2	-0.8
Back pain experienced in last month	0.3	0.5	1.3	-1.1	-0.2	-0.6	-0.7	-0.2	-1.1	-0.3	0.4	-0.8	-0.3	-0.9
Risk taking	0.3	0.4	1.0	-1.0	0.8	0.9	0.4	-0.8	0.3	0.8	0.5	0.1	0.5	0.0
Pain experienced in last month	0.3	0.5	1.3	1.0	0.7	0.1	1.0	0.1	1.1	0.7	-0.7	-0.1	0.6	0.6
Depression (Nagel 2018)	0.2	0.3	1.4	0.1	0.0	-0.2	0.5	-0.0	0.3	0.5	1.2	0.4	-0.1	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.0	-0.8	0.1	-1.2	-1.4	-0.8	-0.6	-0.2	-1.0	-1.4	0.3	-0.2
Reaction Time	0.2	0.3	3.1	0.4	0.3	0.1	0.0	1.8	0.3	0.3	0.1	0.3	0.1	0.0
Ovarian Cancer	0.2	0.3	1.9	1.4	0.4	0.3	-0.4	0.2	-0.3	0.2	0.1	-0.9	0.0	-0.0
Blood Red Count	0.2	2.3	6.5	1.9	-0.1	-2.5	2.1	2.0	2.5	0.4	-0.8	-0.4	-0.4	-0.4
Sensitivity / hurt feelings	0.2	0.4	2.3	-0.2	-0.2	-0.2	0.5	0.5	0.3	0.1	-0.7	-1.5	-0.6	-0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.6	0.4	0.0	0.1	0.5	0.3	0.6	0.4	1.3	-0.1	-0.0	0.8
Impedance of leg (right)	0.2	0.8	4.0	-0.8	0.3	0.3	0.2	0.2	0.8	-0.0	-2.0	-1.6	0.1	-0.7
Average weekly fortified wine intake	0.2	0.3	1.1	-1.0	-0.5	0.7	-0.2	-0.6	-0.2	-0.3	0.1	-0.7	0.1	-0.6
Impedance of leg (left)	0.2	1.1	5.0	-1.1	-0.5	0.2	-0.8	-0.3	0.0	-0.9	-1.8	-2.2	-0.6	-1.0
Alcohol usually taken with meals	0.2	0.3	1.4	0.0	-0.0	-0.3	0.0	0.7	0.4	-0.1	-0.9	-1.2	-0.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	0.6	0.1	0.4	0.6	0.1	-0.2	0.4	1.1	-0.8	-0.5	-0.5
Qualifications: None of the above	0.2	0.5	1.6	-0.8	-0.3	-1.1	-0.1	-0.3	-0.7	-0.3	1.3	0.8	-0.3	-0.3
Impedance of arm (right)	0.2	1.1	3.1	-0.4	-0.7	-0.3	-1.1	0.9	-0.3	-1.0	-1.5	-1.8	-1.0	-1.4
Time employed in main current job	0.2	0.3	0.7	-0.2	-0.8	-0.2	-0.4	0.4	-0.6	-0.8	-0.4	0.3	-0.5	-0.6
Worrier / anxious feelings	0.2	0.4	1.7	0.3	-0.3	-1.1	-0.0	1.3	-0.1	-0.3	-0.4	-0.8	-0.6	-0.6
Falls in the last year	0.2	0.3	0.9	-0.9	-0.4	-0.7	-1.0	-0.3	-0.7	-0.5	0.4	0.1	-0.3	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	0.7	0.1	-0.9	0.2	-0.9	0.2	0.1	0.3	0.6	0.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.0	0.2	0.9	-0.5	0.1	-0.3	0.2	-0.3	0.3	0.5	0.6
Impedance of arm (left)	0.2	1.0	2.5	0.2	-0.5	-0.1	-0.4	1.6	1.0	-0.8	-1.5	-1.4	-1.1	-1.1
Length of working week for main job	0.2	0.3	0.7	-0.6	-0.2	0.3	-0.5	0.9	0.2	-0.3	0.8	0.6	0.3	-0.3
Blood clot in the leg (DVT)	0.2	0.2	0.8	-0.8	-0.3	-0.5	-0.0	-0.4	0.3	0.3	0.7	0.9	0.2	-0.4
High blood pressure (siblings)	0.2	0.3	1.2	0.7	0.2	-0.6	0.0	0.7	0.0	0.5	1.1	0.3	0.7	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.8	-1.3	0.2	0.5	0.1	-0.2	-0.1	0.3	0.6	-0.2	0.2	0.4
Qualifications: College or University degree	0.2	0.7	4.4	1.0	-0.4	0.4	0.3	0.0	0.6	-0.6	-2.1	-1.0	-0.0	-0.9
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.8	0.4	0.1	-0.6	-0.5	-0.6	0.1	-0.5	-0.5	0.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.5	0.4	-0.5	-0.8	0.4	-0.4	0.3	0.5	0.5	-0.4	0.7
Knee pain experienced in last month	0.2	0.3	1.6	-0.2	0.3	-1.3	0.1	0.1	-0.6	0.2	0.2	0.7	0.1	-1.0
Loneliness, isolation	0.2	0.3	0.8	-0.9	-0.3	-0.1	-0.1	0.4	-0.4	-0.4	-0.7	-0.6	-0.1	-0.6
Friendships satisfaction	0.2	0.3	1.0	-0.1	-0.3	0.4	-0.7	-0.7	-0.3	-0.5	0.0	-1.0	-0.3	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.3	-1.1	0.5	0.0	0.2	-0.5	0.1	0.5	-0.0	0.3	0.2	0.2
Mineral and other dietary supplements	0.2	0.3	1.2	0.7	0.7	0.3	0.3	-0.2	0.3	0.8	1.1	0.3	0.4	0.5
Hearing aid user	0.2	0.2	0.9	0.8	-0.4	0.3	0.3	-0.5	0.2	0.3	0.2	0.5	-0.2	0.9
Irritability	0.2	0.3	1.1	-0.3	-0.2	-0.2	0.5	1.1	-0.1	-0.0	-0.0	-1.0	-0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.8	-0.7	-0.5	-0.2	-0.5	0.1	-0.0	0.9	0.3	-0.2	-0.7
Impedance of whole body	0.2	1.1	4.0	-0.2	-0.5	0.3	-0.5	0.9	0.6	-0.9	-1.6	-2.0	-1.0	-1.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	-0.5	0.5	-0.4	-0.3	-0.4	-0.4	0.4	0.7	0.1	0.3	-0.5
Irritable Bowel Disease (IBD)	0.1	0.3	2.1	-0.1	0.5	0.6	0.2	1.5	0.1	0.0	0.4	0.5	0.6	0.2
Tanning	0.1	1.4	3.9	0.1	-1.4	-1.8	0.2	0.3	0.1	-1.3	-1.9	0.2	-1.0	-2.0
Maternal smoking around birth	0.1	0.2	1.1	-0.1	-0.0	1.1	-0.1	-0.4	0.2	-0.2	-0.6	-0.8	0.2	-0.0
Number of live births	0.1	0.2	0.6	-0.1	0.0	-0.7	0.5	-0.4	0.4	-0.0	-0.5	0.8	0.0	0.2
Age started oral contraceptive pill	0.1	0.1	0.4	0.0	-0.1	-0.0	-0.7	-0.2	-0.5	0.0	0.5	0.4	-0.3	0.5
Hair Pigment	0.0	1.1	2.1	-1.1	1.2	0.7	1.2	-0.7	1.4	0.8	0.5	1.1	1.3	1.0

Hub : Genes

TIRAP

Models

Trait associations