Hub : Genes

CDON

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.5240	0.0450	0.0e+00	0.466	0.344	0.438	0.451	0.459	1.7e-63	2.5e-43	1.9e-58	9.4e-61	2.9e-62
2	GTEx	Brain Cerebellar Hemisphere	0.5440	0.1170	1.0e-04	0.542	NA	0.477	NA	0.541	1.9e-16	NA	5.7e-14	NA	2.0e-16
3	GTEx	Brain Cerebellum	0.6350	0.0750	5.9e-08	0.563	NA	0.534	NA	0.545	6.6e-20	NA	1.7e-18	NA	5.0e-19
4	GTEx	Brain Frontal Cortex BA9	0.4778	0.1212	5.2e-04	0.371	NA	0.298	NA	0.358	8.8e-11	NA	1.3e-08	NA	2.3e-10
5	GTEx	Esophagus Mucosa	0.1090	0.0400	3.3e-03	0.038	NA	0.018	NA	0.036	1.4e-03	NA	2.1e-02	NA	1.7e-03
6	GTEx	Esophagus Muscularis	0.1850	0.0600	8.3e-04	0.060	NA	0.020	NA	0.056	1.6e-04	NA	2.0e-02	NA	2.5e-04
7	GTEx	Nerve Tibial	0.1134	0.0466	5.8e-03	0.041	NA	0.015	NA	0.036	6.8e-04	NA	2.6e-02	NA	1.4e-03
8	GTEx	Spleen	0.4090	0.1330	2.1e-03	-0.011	NA	0.029	NA	0.022	8.9e-01	NA	6.0e-02	NA	9.0e-02
9	METSIM	Adipose	0.0615	0.0283	1.1e-02	-0.002	0.004	0.011	0.008	-0.001	8.2e-01	7.0e-02	7.1e-03	2.0e-02	5.2e-01
10	ROSMAP	Brain Pre-frontal Cortex	0.4537	0.0416	0.0e+00	0.444	0.374	0.457	0.439	0.450	5.8e-63	1.1e-50	1.7e-65	3.8e-62	4.6e-64

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.7	4.0	-0.5	-0.5	-0.6	-0.5	-0.2	-0.7	-0.5	2.0	-0.4	-0.7
Bipolar Disorder or Schizophrenia	1.6	3.8	6.1	-2.4	-2.4	-2.5	-2.2	-1.7	-0.1	-2.4	0.8	-0.9	-2.3
Depressed Affect (Nagel 2018)	0.4	0.9	1.6	-0.9	-1.0	-1.0	-0.9	-1.3	-1.0	-0.5	0.4	1.0	-1.1
Depression (Nagel 2018)	0.3	0.5	2.4	-0.3	-0.5	-0.4	-0.4	-1.6	0.1	-0.1	-0.4	0.9	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.1	1.1	1.1	1.2	1.0	1.8	-0.3	1.5	0.3	0.4	1.2
Neuroticism (Nagel 2018)	0.5	1.1	2.6	-1.0	-1.1	-1.1	-1.0	-1.6	-1.0	-0.7	-0.0	1.3	-1.0
Schizophrenia (2018)	2.2	4.7	7.4	-2.7	-2.7	-2.7	-2.4	-2.0	0.5	-2.7	-0.6	-0.9	-2.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.5	0.3	0.3	0.3	0.5	0.9	0.0	-0.4	-1.2	-1.1	0.4
Worry (Nagel 2018)	0.4	0.9	3.1	-0.3	-0.5	-0.5	-0.3	-1.8	-1.4	0.2	-0.9	1.4	-0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.1	-0.2	-0.2	0.1	0.4	0.1	0.1	-0.6	0.2	-0.4
Alzheimer’s Disease (in father)	1.7	1.9	2.8	1.6	1.7	1.7	1.4	-0.1	0.5	1.6	1.1	1.3	1.6
Alzheimer’s Disease (including proxy)	0.2	0.2	0.5	0.4	0.4	0.4	0.5	0.0	0.6	0.7	0.5	0.6	0.3
Crohns Disease (2017)	0.7	1.6	5.5	-0.6	-0.7	-0.8	-0.6	-2.3	-1.7	0.0	1.1	-2.1	-0.9
Irritable Bowel Disease (IBD)	0.5	1.3	6.7	0.2	0.1	0.1	0.1	-1.8	-2.6	1.0	0.3	-1.3	-0.2
Ulcerative Colitis (UC)	0.7	1.3	3.8	1.1	1.0	1.0	1.0	-0.9	-1.9	1.6	-0.9	0.2	0.7
Major Depression (MDD)	0.4	0.5	3.7	-0.3	-0.4	-0.4	-0.3	-0.8	-1.9	0.2	-0.3	0.5	-0.2
Reaction Time	0.2	0.3	1.6	0.2	0.2	0.3	0.3	-0.5	1.3	0.0	0.4	1.0	0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.5	1.1	1.1	1.2	0.9	1.9	0.8	1.0	0.1	0.8	1.4
Breast Cancer	0.6	1.3	4.8	-0.6	-0.2	-0.2	-0.3	1.9	1.7	-1.2	2.2	0.4	-0.1
Ovarian Cancer	2.5	3.3	12.9	1.1	1.4	1.5	1.2	3.6	1.7	0.7	2.0	2.0	1.4
Prostate Cancer	0.4	0.6	2.3	-0.6	-0.8	-0.8	-0.8	-1.0	-0.2	0.1	-1.5	-0.2	-0.7
Age at First Birth	0.5	0.7	1.6	-1.0	-1.0	-1.0	-0.9	-0.2	-0.1	-0.5	-0.5	-1.3	-1.0
Bipolar Disorder (2011)	2.6	2.5	3.9	-1.9	-2.0	-2.0	-1.6	-0.4	-0.7	-1.9	-1.2	-1.4	-1.9
Body Mass Index (BMI) (2010)	0.5	0.6	1.7	0.7	0.8	0.8	0.7	-0.3	-0.9	0.4	1.3	0.5	0.9
Coronary Artery Disease (CAD)	0.7	0.8	2.1	0.9	0.8	0.8	0.8	-0.3	-1.4	1.0	1.2	0.2	0.8
Crohns Disease (2012)	1.1	1.8	5.0	-1.1	-1.1	-1.1	-1.1	-2.0	-1.1	-0.6	1.1	-2.2	-1.1
Mean Putamen Volume	0.4	0.4	1.9	-0.4	-0.3	-0.4	-0.2	-1.4	-0.9	-0.1	-0.6	-0.7	-0.4
Fasting Glucose	0.2	0.2	0.7	-0.3	-0.4	-0.3	-0.4	-0.3	-0.8	0.2	-0.8	-0.0	-0.3
HbA1C	0.9	1.0	2.2	1.1	0.9	0.9	1.0	-1.3	0.3	1.5	-0.9	0.0	1.0
HDL Cholesterol	0.1	0.2	1.0	0.2	0.3	0.3	0.6	0.6	-0.5	0.3	-1.0	0.3	0.0
LDL Cholesterol	0.8	1.3	5.5	-1.0	-0.9	-0.9	-1.5	0.1	0.3	-1.2	2.4	0.2	-1.1
Lupus	0.1	0.2	0.8	-0.5	-0.5	-0.5	-0.1	-0.3	-0.9	0.0	-0.2	0.4	-0.4
Neuroticism (2016)	1.7	2.4	3.9	-1.7	-1.8	-1.8	-1.7	-1.4	-2.0	-1.3	0.3	-0.8	-1.8
Primary Biliary Cirrhosis	1.5	2.2	3.4	-1.8	-1.8	-1.8	-1.6	-1.2	-0.2	-1.4	0.3	-1.7	-1.7
Rheumatoid Arthritis	0.3	0.3	0.8	0.5	0.6	0.7	0.7	0.5	-0.5	0.4	-0.9	-0.4	0.5
Schizophrenia (2014)	1.4	3.1	6.9	-2.1	-2.2	-2.2	-1.9	-1.1	0.0	-2.6	-0.6	-1.2	-2.0
Triglycerides	0.3	0.5	1.7	0.5	0.3	0.3	0.2	-0.8	-1.3	1.0	-0.6	0.7	0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.6	-0.7	-0.7	-0.5	-0.1	-0.1	-0.3	-0.5	0.2	-0.5
Ulcerative Colitis	0.5	0.7	1.6	-0.6	-0.6	-0.7	-0.5	-1.2	-1.0	-0.5	0.1	-1.3	-0.8
Blood Eosinophil Count	0.2	1.8	14.0	0.6	0.6	0.6	1.4	-0.5	0.6	0.3	-3.7	0.7	0.5
Blood Platelet Count	0.1	0.7	3.1	0.6	0.6	0.6	0.6	-1.8	-0.9	0.2	-0.1	1.2	0.7
Blood Red Count	0.3	2.7	7.0	1.7	1.7	1.7	1.6	0.1	0.7	2.1	0.6	2.6	1.7
Blood White Count	0.4	3.2	6.8	2.0	1.8	1.8	1.9	-0.4	-0.3	2.6	-0.7	2.6	2.0
Heel T-Score	0.6	5.1	11.0	-2.3	-1.9	-1.9	-2.1	1.2	3.3	-2.8	3.0	-1.4	-1.8
BMI	0.2	1.0	4.0	-0.8	-0.9	-0.9	-0.9	-0.6	2.0	-0.7	1.3	-0.0	-0.9
Height	0.6	11.1	80.3	1.0	0.5	0.4	0.3	-3.9	-9.0	2.9	-2.1	-1.2	-0.9
Waist Hip Ratio (WHR)	0.1	0.6	2.1	-0.4	-0.3	-0.2	-0.1	1.3	1.4	-1.2	0.4	-0.3	0.1
Systolic Blood Pressure	0.4	2.1	4.1	1.9	1.8	1.8	1.5	0.3	-0.9	2.0	0.6	-0.4	1.8
Smoking Status	0.1	0.3	1.8	-0.3	-0.3	-0.3	-0.3	-0.3	0.8	-0.5	-1.3	-0.2	-0.2
Allergy or Eczema	0.6	1.5	2.6	1.1	1.2	1.2	1.3	1.6	0.5	1.5	-0.7	1.3	1.4
Cardiovascular Disease	0.1	0.3	0.9	0.4	0.3	0.2	-0.0	-0.6	-0.9	0.3	1.0	0.7	0.1
Hypothyroidism (self reported)	0.4	0.8	3.1	-0.3	-0.2	-0.2	-0.3	0.8	1.3	-1.2	-1.1	1.8	0.0
Respiratory disease	0.1	0.2	0.7	0.2	0.1	0.1	0.3	-0.3	0.8	0.4	0.5	0.3	0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.9	-0.5	-0.3	-0.3	-0.2	0.0	0.9	-0.5	1.4	0.6	-0.3
Lung FEV1/FVC ratio	3.3	17.0	28.7	-5.0	-4.8	-4.7	-4.7	-0.2	4.3	-5.4	-1.2	-3.2	-4.3
Lung FVC	0.7	3.8	16.6	1.8	1.6	1.6	1.8	-0.7	-0.8	2.7	-4.1	0.6	1.1
Neuroticism	0.3	0.8	3.5	0.0	-0.1	-0.1	0.1	-1.4	-1.9	0.3	0.3	1.6	-0.1
Chronotype (morning person)	0.4	1.0	5.6	-0.2	-0.3	-0.3	-0.3	-0.5	-2.4	0.4	-1.7	-0.0	-0.5
Hair Pigment	0.0	1.3	2.3	1.3	1.2	1.2	1.1	0.1	-1.5	1.4	-0.9	0.8	1.0
Tanning	0.1	0.6	2.3	0.8	0.7	0.7	0.8	-1.0	-0.4	0.6	-1.5	0.4	0.6
Hand grip strength (left)	0.2	0.5	1.8	0.5	0.4	0.4	0.4	0.6	-1.3	1.3	-0.2	0.9	0.1
Number of treatments/medications taken	0.4	0.8	2.0	-0.8	-0.9	-0.9	-0.9	-1.4	0.8	-0.4	1.2	-0.1	-0.7
Average weekly spirits intake	1.1	1.3	2.1	-1.4	-1.4	-1.4	-1.1	-1.0	0.7	-1.1	0.6	-0.9	-1.5
Sensitivity / hurt feelings	0.2	0.3	1.0	0.4	0.4	0.4	0.4	0.2	-0.9	-0.1	0.1	-1.0	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.6	-0.0	-0.0	-0.0	-0.1	-0.7	0.2	0.2	0.7	1.3	-0.2
Hearing difficulty/problems: Yes	2.0	3.1	5.9	-2.2	-2.0	-2.0	-2.1	-0.2	1.0	-2.4	1.7	0.5	-2.0
Relative age of first facial hair	0.5	1.1	3.7	0.6	0.4	0.4	0.5	-0.8	-1.8	1.2	-1.9	-0.8	0.3
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.4	-1.7	-1.6	-1.6	-1.5	-0.8	1.5	-1.8	0.0	-1.0	-1.6
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.1	0.9	1.0	1.0	1.1	0.8	1.4	0.6	1.3	1.1	1.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.9	-0.9	-0.9	-1.2	0.6	0.5	-0.5	-0.3	0.2	-1.1
Systolic blood pressure, automated reading	1.4	3.9	6.0	2.3	2.4	2.4	2.0	2.1	0.2	2.4	1.2	0.6	2.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.8	-0.4	-0.3	-0.3	-0.3	-0.2	0.2	-0.9	0.8	0.5	-0.2
Angina	0.4	0.6	1.4	-0.7	-0.8	-0.8	-0.9	-1.2	-0.2	-0.6	0.8	-0.8	-0.6
Medication for hormone replacement therapy	0.5	0.5	2.3	0.4	0.6	0.6	0.5	0.7	0.7	-0.2	0.8	1.5	0.4
Vitamin and mineral supplements	0.7	1.0	2.8	0.9	0.9	0.9	0.8	-0.2	0.6	1.7	0.8	1.4	0.9
Supplements: Zinc	1.4	1.5	2.9	-1.2	-1.3	-1.3	-1.3	-1.6	-0.6	-1.2	-0.2	-1.7	-1.2
Medication: Co-codamol	1.3	1.5	4.9	-1.4	-1.4	-1.5	-1.1	-0.7	-0.4	-0.6	0.0	-2.2	-1.3
Medication: Metformin	0.9	1.2	4.6	-1.2	-1.1	-1.1	-0.9	0.3	1.1	-2.1	0.6	-0.5	-0.9
Diabetes (father)	0.6	0.8	2.5	0.7	0.7	0.8	0.9	1.1	1.6	0.5	0.5	0.7	1.0
Diabetes (mother)	1.1	1.4	5.3	0.8	0.8	0.8	1.1	-0.3	1.6	1.3	-2.3	-0.1	0.9
Severe depression (siblings)	0.2	0.2	0.9	-0.5	-0.5	-0.4	-0.6	0.5	-0.2	0.4	-1.0	0.1	-0.3
Pack years adult smoking proportion	1.9	2.9	5.3	-1.6	-1.6	-1.6	-1.3	-0.2	-1.8	-1.8	-2.3	-2.2	-1.7
Impedance of leg (right)	0.1	0.7	1.1	-1.1	-1.1	-1.0	-1.0	0.8	-0.6	-0.5	0.7	0.0	-0.9
Leg fat-free mass (left)	0.1	0.7	2.0	0.8	0.6	0.6	0.5	-1.1	-1.4	1.1	-0.9	-0.3	0.4
Trunk fat percentage	0.6	2.4	3.5	-1.8	-1.8	-1.9	-1.9	-1.6	0.0	-1.1	0.2	-1.9	-1.8
Hand grip strength (right)	0.2	0.6	1.5	0.5	0.4	0.4	0.3	0.8	-1.2	1.1	0.5	1.2	0.3
Townsend deprivation index at recruitment	0.8	1.1	5.9	-0.3	-0.1	-0.0	-0.3	0.8	2.4	-0.5	1.9	0.5	0.1
Current tobacco smoking	0.5	0.8	2.6	-0.8	-0.8	-0.8	-0.6	-0.2	0.9	-0.5	-1.6	-1.2	-0.7
Average weekly fortified wine intake	0.8	1.0	2.2	-1.2	-1.0	-1.0	-0.8	-0.1	0.7	-1.0	1.2	0.4	-1.5
Maternal smoking around birth	0.9	1.3	6.0	-0.6	-0.7	-0.8	-0.6	-1.9	-0.9	-0.3	0.6	-2.4	-0.8
Fed-up feelings	1.3	2.4	3.6	-1.9	-1.8	-1.9	-1.7	-0.6	-0.7	-1.4	1.8	1.1	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	-0.6	-0.7	-0.6	-0.6	-1.5	-0.8	-0.8	-0.1	1.0	-1.0
Relative age voice broke	0.5	0.8	4.4	-0.1	-0.1	-0.1	0.1	0.2	-1.7	0.0	-2.1	0.4	-0.1
Taking other prescription medications	0.1	0.2	0.7	-0.2	-0.4	-0.4	-0.2	-0.8	0.4	0.1	-0.0	0.9	-0.2
Age when periods started (menarche)	0.2	0.5	2.6	-0.0	0.0	0.1	0.0	1.6	-1.5	0.1	0.4	-0.5	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	-0.6	-0.5	-0.5	-0.7	0.4	0.7	-1.1	0.8	0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	4.9	-2.1	-2.0	-2.0	-2.2	-0.6	0.4	-1.8	-0.6	-1.3	-2.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.1	0.1	0.1	0.1	-0.1	0.1	0.6	-0.4	-0.5	0.2
Qualifications: CSEs or equivalent	1.3	1.7	4.2	1.6	1.4	1.4	1.8	-1.1	-0.1	2.1	-0.1	0.5	1.1
Serious illness, injury or assault to yourself	0.2	0.2	0.7	0.1	0.1	0.0	-0.0	-0.9	0.8	-0.2	0.6	-0.5	0.1
High blood pressure	0.2	0.5	2.1	0.6	0.6	0.6	0.2	-0.3	0.0	0.5	1.5	1.1	0.7
Hayfever, allergic rhinitis or eczema	0.7	1.4	3.1	1.0	1.0	1.0	1.1	1.5	0.1	1.4	-1.1	1.8	1.2
Multivitamins +/- minerals	1.4	1.8	4.1	-1.5	-1.5	-1.5	-1.5	-0.1	-0.5	-2.0	-0.6	-1.5	-1.6
Stomach or abdominal pain in last month	2.2	2.7	5.0	-2.2	-2.2	-2.2	-2.1	-0.7	-0.4	-1.6	-1.1	-0.3	-2.0
Supplements: Glucosamine	0.2	0.3	1.1	-0.2	-0.3	-0.3	-0.4	-1.0	-0.4	0.5	-0.0	-1.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	1.1	1.2	1.2	1.0	0.3	0.2	0.8	-0.5	0.1	1.0
Medication: Atenolol	0.2	0.2	1.3	0.1	0.1	0.1	-0.3	0.2	-0.8	-0.2	1.1	-0.2	0.1
Medication: Levothyroxine sodium	0.4	0.7	1.6	-1.0	-1.0	-1.0	-0.9	0.2	-0.1	-1.3	-0.8	0.3	-0.7
Sitting height	1.8	13.0	56.1	3.3	2.9	2.9	2.7	-0.8	-7.5	4.6	-3.6	0.2	1.8
Chronic bronchitis/emphysema (father)	0.4	0.4	1.5	-0.2	-0.2	-0.2	-0.1	-1.2	-1.2	-0.7	-0.3	-0.6	-0.3
High blood pressure (mother)	0.4	0.5	1.0	-0.8	-0.8	-0.8	-1.0	-0.0	1.0	-0.5	-0.2	0.7	-0.7
Body mass index (BMI)	0.3	1.2	2.2	-1.1	-1.1	-1.1	-1.1	-1.1	1.5	-1.1	0.3	-1.4	-0.9
Impedance of leg (left)	0.2	1.0	1.8	-1.3	-1.3	-1.3	-1.2	0.5	-1.0	-0.7	0.4	-0.1	-1.3
Leg predicted mass (left)	0.1	0.7	1.8	0.8	0.6	0.6	0.5	-1.2	-1.3	1.1	-0.9	-0.3	0.4
Trunk fat mass	0.5	2.2	3.2	-1.6	-1.7	-1.7	-1.8	-1.7	-0.5	-1.0	0.1	-1.8	-1.8
Waist circumference	0.2	0.9	2.6	-0.8	-0.8	-0.7	-0.8	-1.0	1.1	-0.8	0.6	-1.6	-0.7
Number of incorrect matches in round	0.3	0.5	1.2	0.5	0.6	0.6	0.6	0.2	-0.6	0.6	1.1	-1.1	0.7
Past tobacco smoking	0.5	0.8	3.4	0.5	0.8	0.8	0.8	1.8	0.6	-0.0	1.3	0.7	0.8
Alcohol usually taken with meals	0.1	0.1	0.7	0.1	0.1	0.1	0.1	0.1	0.0	0.9	-0.2	0.2	-0.1
Nervous feelings	0.3	0.5	2.1	-0.7	-0.7	-0.7	-0.7	-0.1	-1.4	-0.4	-0.1	0.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.8	-1.0	-1.0	-1.0	-0.9	-1.0	-0.8	-0.7	-0.1	0.3	-1.3
Hearing difficulty/problems with background noise	0.6	1.0	2.2	-1.1	-1.0	-1.0	-1.2	-0.4	1.5	-1.1	1.0	0.5	-1.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.3	0.3	0.3	0.4	-0.5	0.6	-0.1	-0.6	0.8	0.2
Had menopause	0.5	0.6	2.2	-0.2	-0.2	-0.2	-0.4	-1.1	-1.3	-0.4	1.5	-0.8	-0.4
Had other major operations	0.2	0.3	1.3	0.1	0.1	0.1	0.3	-0.3	0.2	1.0	1.2	0.6	0.2
Forced vital capacity (FVC)	0.8	3.2	13.5	0.7	0.4	0.4	0.5	-0.5	-3.5	2.2	-3.7	0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.6	7.7	-2.5	-2.6	-2.6	-2.8	-1.4	0.2	-2.3	-0.7	-2.2	-2.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	0.9	0.8	0.8	0.5	-0.5	-1.2	0.8	-1.1	-0.0	0.8
Qualifications: None of the above	0.4	0.8	1.5	0.9	0.9	0.9	0.9	-0.8	-0.6	1.2	-0.2	1.2	0.8
Financial difficulties in last 2 years	1.1	1.5	3.5	1.5	1.4	1.4	1.3	0.3	1.2	1.9	-0.2	0.4	1.4
Mouth/teeth dental problems	0.2	0.3	1.6	0.2	0.4	0.4	0.2	1.2	0.0	-0.5	0.7	-0.2	0.5
Heart attack	0.6	0.8	3.0	-0.1	-0.3	-0.4	-0.4	-1.7	-1.0	-0.3	-0.7	-1.6	-0.4
Allergy	0.4	0.9	2.2	-0.8	-0.8	-0.8	-1.1	-1.0	0.2	-1.2	0.9	-1.5	-0.9
Pain all over the body in last month	0.6	0.6	2.8	-0.7	-0.7	-0.8	-0.8	-0.7	0.4	-0.3	-1.7	-0.1	-0.8
Diabetes (self-reported)	2.1	3.2	6.9	-2.3	-2.2	-2.2	-2.0	0.3	1.3	-2.6	0.7	-0.7	-1.9
Hayfever/allergic rhinitis (self-reported)	3.6	4.8	7.3	2.6	2.5	2.4	2.7	0.5	-0.2	2.7	-2.7	0.9	2.5
Medication: Ramipril	0.3	0.4	1.3	0.7	0.6	0.7	0.7	1.1	-0.3	0.3	0.2	0.7	0.7
Medication: Simvastatin	1.6	2.4	5.0	-1.9	-1.9	-1.9	-2.2	0.9	1.1	-1.7	0.8	-0.1	-1.5
Fluid intelligence score	0.4	0.8	3.6	0.3	0.3	0.4	0.1	1.9	0.5	0.4	1.6	1.1	0.7
Illnesses of siblings	0.2	0.3	1.5	-0.2	-0.1	-0.1	0.0	1.2	0.6	-0.3	0.8	0.5	-0.0
Neuroticism score	0.2	0.5	2.8	0.1	-0.0	-0.0	0.2	-1.0	-1.7	0.6	0.2	1.0	-0.0
Weight	0.3	1.3	3.1	-0.9	-1.0	-1.0	-1.1	-1.8	-1.2	-0.4	-0.5	-1.6	-1.2
Impedance of arm (right)	0.1	0.6	3.3	0.5	0.4	0.4	0.6	-0.0	-1.8	1.1	-0.2	0.3	0.4
Arm fat percentage (right)	0.3	1.2	2.2	-1.1	-1.2	-1.2	-1.2	-1.5	0.3	-0.9	0.2	-1.4	-1.1
Trunk fat-free mass	0.2	0.9	5.3	0.6	0.5	0.5	0.2	-0.9	-2.3	0.7	-1.0	-0.3	-0.0
Hip circumference	0.1	0.6	2.8	-0.2	-0.2	-0.3	-0.4	-1.7	-0.8	0.3	0.3	-1.5	-0.4
Time employed in main current job	0.7	0.8	2.2	0.8	0.9	0.9	0.9	1.0	0.6	0.7	0.5	-1.5	0.7
Alcohol intake versus 10 years previously	0.4	0.5	2.4	-0.7	-0.7	-0.7	-0.7	-0.8	0.0	-0.5	-1.6	-0.2	-0.5
Father’s age at death	1.7	2.3	8.8	-1.5	-1.3	-1.2	-1.4	1.3	3.0	-1.3	1.2	0.9	-0.9
Worrier / anxious feelings	0.8	1.5	4.7	1.1	1.0	0.9	0.9	-1.5	-1.4	2.2	-1.1	0.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	-0.6	-0.6	-0.6	-0.6	0.3	0.1	-1.0	-0.1	0.3	-0.4
Falls in the last year	0.9	1.2	5.2	0.8	0.7	0.6	0.8	-1.0	-1.2	0.6	-2.3	-1.2	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.5	0.1	0.0	0.0	-0.1	0.3	-0.7	0.4	-0.7	-0.4	0.3
Number of live births	0.4	0.6	1.0	0.9	1.0	1.0	0.9	0.2	0.5	1.0	-0.1	-0.5	1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	9.1	-0.3	-0.5	-0.5	-0.4	-0.7	-1.9	0.9	-3.0	-0.3	-1.0
Pulse rate	1.0	1.7	2.9	1.7	1.6	1.6	1.7	-0.5	-0.5	1.7	-0.9	0.6	1.4
Happiness	1.0	1.2	3.1	1.1	1.3	1.3	1.2	0.9	-0.5	0.5	0.2	1.8	1.3
Noisy workplace	3.3	4.1	6.5	-2.3	-2.3	-2.4	-2.2	-1.8	-0.4	-2.2	-1.6	-1.6	-2.5
Qualifications: A levels/AS levels or equivalent	0.3	0.8	4.9	-0.3	-0.3	-0.3	-0.3	-0.3	2.2	0.0	1.5	-0.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.8	-0.4	-0.6	-0.6	-0.6	-1.3	-0.7	-0.6	0.4	-0.4	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.4	2.1	0.4	0.1	0.1	-0.1	-0.1	-0.9	0.7	-1.4	-0.1	0.1
Asthma	0.1	0.2	0.8	-0.3	-0.4	-0.4	-0.1	-0.9	0.5	0.3	0.6	0.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	5.2	0.6	0.5	0.5	0.8	-2.3	1.5	1.1	0.6	0.7	0.5
Medication: Cholesterol lowering	1.2	1.9	3.3	-1.5	-1.5	-1.5	-1.8	-0.5	0.4	-1.8	1.8	-0.1	-1.4
Depression (self-reported)	0.3	0.4	1.9	-0.2	-0.3	-0.3	-0.1	-1.4	-1.2	0.4	0.0	0.1	-0.6
Medication: Lansoprazole	1.1	1.2	2.7	1.4	1.3	1.3	1.3	-0.4	0.1	1.6	0.9	0.7	1.2
Prospective memory result	0.6	0.7	1.4	-0.8	-0.8	-0.8	-0.6	-0.8	0.3	-1.0	-0.8	-1.2	-1.0
Lung cancer (father)	0.3	0.3	0.8	-0.6	-0.6	-0.6	-0.6	0.4	-0.9	-0.5	0.5	-0.5	-0.5
Illnesses of mother	1.0	1.2	2.7	-1.0	-1.0	-0.9	-1.0	1.1	-1.5	-1.2	1.6	-0.2	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	9.5	-0.8	-0.9	-0.9	-0.9	-0.3	-1.8	0.2	-3.1	-0.4	-1.3
Pulse wave Arterial Stiffness index	0.2	0.3	2.1	-0.0	0.0	0.0	-0.2	0.1	-0.1	0.7	1.4	-0.1	0.1
Impedance of arm (left)	0.1	0.4	2.0	0.3	0.3	0.3	0.4	0.4	-1.4	0.9	-0.1	0.2	0.4
Arm fat mass (right)	0.2	0.9	2.3	-0.8	-0.9	-1.0	-1.0	-1.5	-0.2	-0.5	0.2	-1.3	-1.0
Trunk predicted mass	0.2	0.9	5.2	0.8	0.6	0.6	0.3	-0.9	-2.3	0.9	-1.0	-0.3	0.1
Standing height	0.4	4.2	32.9	0.7	0.5	0.5	0.2	-1.4	-5.7	2.0	-1.6	-0.2	-0.4
Length of working week for main job	0.2	0.3	1.0	0.2	0.3	0.3	0.3	0.8	-0.2	-0.5	0.5	1.0	0.4
Exposure to tobacco smoke at home	0.8	0.9	2.0	-0.9	-1.0	-1.0	-0.6	-0.4	-1.4	-1.1	-1.1	-0.2	-1.1
Breastfed as a baby	0.3	0.3	2.6	0.3	0.3	0.3	-0.0	-0.4	0.5	-0.1	1.6	0.1	0.4
Tense / ‘highly strung’	0.2	0.4	1.4	-0.3	-0.3	-0.3	-0.0	-0.1	-1.0	0.1	0.9	1.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	6.1	-0.8	-0.8	-0.8	-1.0	0.0	2.5	-0.5	2.3	0.8	-0.4
Hair/balding pattern: Pattern 4	2.0	4.8	9.9	-2.3	-2.4	-2.4	-2.7	-1.1	3.1	-1.6	2.3	-1.1	-1.9
Birth weight of first child	3.0	5.4	9.7	-2.6	-2.7	-2.7	-2.8	-1.3	-1.4	-2.5	-0.4	-2.3	-3.1
Peak expiratory flow (PEF)	0.6	1.5	2.7	-1.5	-1.5	-1.5	-1.5	-0.4	-0.1	-0.7	-1.4	-0.6	-1.6
Pulse wave reflection index	1.1	1.3	5.7	-1.1	-0.9	-0.9	-1.1	0.7	0.6	-1.0	2.4	-1.0	-0.9
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.7	0.5	0.4	0.4	0.4	-0.8	-0.8	0.7	0.5	-0.2	0.4
Loud music exposure frequency	0.4	0.4	1.3	-0.5	-0.7	-0.7	-0.7	0.2	-0.9	-0.3	-1.1	-0.4	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	3.7	-0.9	-0.9	-0.9	-0.9	0.4	0.7	-0.8	0.0	-1.9	-0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.0	-1.4	-1.4	-1.4	-1.1	-0.7	1.4	-1.2	-1.0	-0.5	-1.3
Blood clot in the leg (DVT)	1.7	2.1	3.6	1.8	1.8	1.8	1.8	-0.5	0.7	0.7	0.8	1.8	1.9
Medication: Paracetamol	0.4	0.6	1.1	0.9	0.9	0.9	1.0	0.3	0.7	1.0	-0.5	-0.0	1.0
Headache pain in last month	0.2	0.3	1.0	0.2	0.2	0.1	0.3	-0.8	1.0	0.5	-0.0	0.8	0.3
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.4	2.1	2.1	2.1	2.3	1.2	-0.2	2.1	-1.4	0.1	2.0
Glaucoma (self-reported)	0.9	1.1	3.7	-0.8	-0.5	-0.4	-0.2	1.4	-1.1	-0.8	1.9	1.5	-0.6
Gout (self-reported)	0.6	0.8	1.5	1.0	1.0	1.0	0.9	0.8	-0.6	0.5	1.2	0.9	1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.3	-0.5	-0.4	-0.4	-0.4	0.2	0.5	-1.1	-0.8	1.1	-0.2
Medication: Amlodipine	0.8	1.1	2.2	-1.4	-1.4	-1.4	-1.5	-0.8	-0.5	-0.6	-0.5	-0.1	-1.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.1	-0.0	-0.2	-0.2	0.1	-0.8	1.0	0.4	-1.5	-0.1	-0.0
Birth weight	0.1	0.2	0.7	-0.5	-0.5	-0.4	-0.5	-0.2	-0.6	-0.3	-0.9	-0.0	-0.3
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.5	0.6	0.6	0.5	0.6	-0.3	-0.0	0.6	-1.0	-1.2	0.3
High blood pressure (siblings)	0.2	0.3	1.3	0.5	0.4	0.4	0.4	-0.7	1.1	0.7	-0.1	-0.4	0.3
Forced vital capacity (FVC), Best measure	0.5	2.0	9.2	0.2	0.0	0.0	0.0	-0.2	-2.8	1.5	-3.0	0.2	-0.5
Body fat percentage	0.6	2.3	3.5	-1.8	-1.8	-1.8	-1.8	-1.6	0.6	-1.2	0.3	-1.9	-1.7
Leg fat percentage (right)	0.6	2.3	3.3	-1.7	-1.8	-1.8	-1.8	-1.2	1.3	-1.6	0.7	-1.6	-1.5
Arm fat-free mass (right)	0.1	0.6	2.1	-0.0	-0.1	-0.1	-0.4	-1.2	-1.5	0.2	-0.9	-0.8	-0.5
Exposure to tobacco smoke outside home	1.2	1.6	3.7	-1.2	-1.2	-1.2	-1.3	-0.8	1.6	-1.9	-0.7	-0.8	-1.1
Comparative body size at age 10	0.3	0.9	4.7	-0.0	0.1	0.1	-0.3	0.7	1.6	-0.5	2.2	1.1	0.1
Number of full brothers	2.1	2.7	5.7	-2.0	-1.9	-1.9	-1.5	-0.3	-0.7	-2.4	-0.1	-1.8	-1.9
Worry too long after embarrassment	0.5	0.8	2.7	-0.8	-0.9	-0.9	-0.9	-0.8	-1.6	-0.9	-0.6	-0.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	-1.1	-1.2	-1.2	-1.1	-0.9	-0.5	-0.0	0.8	-0.4	-1.3
Wheeze or whistling in the chest in last year	0.2	0.4	3.3	-0.1	-0.1	-0.1	0.2	0.4	1.8	0.2	0.6	0.1	0.3
Number of children fathered	0.3	0.4	2.0	0.3	0.2	0.2	0.5	0.7	-0.0	0.8	-1.4	0.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.7	-0.1	-0.1	-0.1	-0.1	0.4	-0.2	0.0	-0.8	1.3	-0.0
Age at first live birth	0.2	0.4	0.8	-0.8	-0.7	-0.7	-0.6	-0.4	-0.2	-0.8	-0.1	-0.3	-0.9
Pulse wave peak to peak time	0.2	0.3	2.2	0.0	-0.0	-0.0	0.1	-0.2	-0.4	-0.6	-1.5	0.1	-0.1
Health satisfaction	0.6	0.8	4.4	-0.1	-0.3	-0.3	-0.0	-2.1	-1.3	-0.5	-1.2	0.2	-0.3
Shortness of breath walking on level ground	1.5	1.8	6.2	-1.0	-1.2	-1.2	-1.2	-2.5	0.2	-0.9	-0.5	-2.0	-1.4
Qualifications: College or University degree	0.6	1.9	8.6	-0.8	-0.6	-0.5	-0.5	1.8	2.9	-1.5	1.4	1.2	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.1	0.0	0.0	-0.0	0.5	0.5	0.2	-0.5	0.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.7	0.7	0.7	0.6	0.1	-0.3	0.8	0.5	0.7	0.5
Emphysema/chronic bronchitis	2.3	2.6	5.9	-1.8	-1.7	-1.7	-1.5	-0.3	0.4	-2.4	1.7	-1.7	-1.7
Medication for pain relief, constipation, heartburn	0.6	1.0	2.0	-1.1	-1.1	-1.1	-1.2	0.2	-1.4	-0.9	0.1	-0.6	-1.1
Neck or shoulder pain in last month	1.0	1.5	13.7	0.2	-0.1	-0.2	0.1	-3.7	-0.4	0.2	-0.6	-0.4	-0.2
Medication: Blood pressure	1.1	2.0	3.6	-1.8	-1.8	-1.8	-1.9	-0.6	0.8	-1.8	0.1	-0.1	-1.6
Angina (self-reported)	0.4	0.5	1.9	-0.6	-0.7	-0.7	-0.7	-1.4	-0.2	-0.4	0.3	-1.0	-0.5
Migraine (self-reported)	0.2	0.2	0.8	0.3	0.4	0.3	0.5	-0.3	0.2	0.2	0.9	-0.7	0.3
Medication: Ibuprofen	0.7	0.8	5.1	-0.0	-0.1	-0.1	0.2	-2.3	1.4	0.6	0.7	0.3	-0.1
Medication: Allopurinol	0.2	0.2	1.0	0.3	0.3	0.3	0.2	1.0	-0.7	-0.0	0.8	0.0	0.2
Medication: Omeprazole	0.4	0.5	2.2	-0.3	-0.4	-0.4	-0.3	-1.5	0.4	-0.4	-1.4	0.1	-0.4
Medication: Seretide 50 evohaler	1.2	1.4	2.8	1.2	1.1	1.0	1.2	-1.0	-1.6	1.7	-1.3	-0.0	0.8
Mean time to correctly identify matches	0.1	0.2	1.4	0.0	0.1	0.2	0.0	-0.6	1.2	-0.4	0.3	0.2	-0.0
Heart disease (mother)	0.1	0.2	0.3	0.3	0.4	0.4	0.3	-0.6	0.6	0.4	0.2	-0.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.4	7.1	2.2	2.3	2.3	2.1	0.8	0.9	2.4	2.3	2.7	2.1
Whole body fat mass	0.4	1.8	3.4	-1.3	-1.4	-1.4	-1.5	-1.8	-0.4	-0.8	-0.1	-1.8	-1.5
Leg fat mass (right)	0.6	2.2	3.5	-1.6	-1.7	-1.7	-1.8	-1.6	0.2	-1.3	0.2	-1.9	-1.6
Arm predicted mass (right)	0.1	0.5	2.3	0.0	-0.1	-0.1	-0.3	-1.1	-1.5	0.1	-0.9	-0.7	-0.4
Pulse rate, automated reading	0.0	0.1	0.4	0.2	0.1	0.1	0.0	-0.5	0.2	0.1	0.4	0.6	0.2
Alcohol intake frequency.	0.3	0.6	2.7	0.0	0.2	0.2	0.1	1.5	0.8	-0.2	1.7	-0.0	0.4
Comparative height size at age 10	0.3	1.8	7.3	-0.6	-0.6	-0.7	-1.0	-1.8	-2.7	0.1	-1.7	-1.2	-1.3
Number of full sisters	0.4	0.5	1.7	-0.4	-0.5	-0.5	-0.4	-1.0	0.9	-0.2	-0.3	-1.3	-0.7
Suffer from ‘nerves’	0.3	0.5	2.4	-0.2	-0.3	-0.3	-0.1	-0.9	-1.1	0.5	0.0	1.5	-0.1
Overall health rating	0.8	1.8	3.3	-1.7	-1.8	-1.8	-1.8	-1.2	0.7	-1.2	0.4	-0.2	-1.4
Chest pain or discomfort	1.7	2.4	6.7	-1.5	-1.5	-1.5	-1.7	-2.6	0.7	-1.4	1.4	-0.9	-1.5
Had major operations	0.4	0.5	1.5	-0.9	-0.8	-0.7	-0.9	0.3	-0.6	-1.2	0.3	0.2	-0.5
Age at last live birth	0.6	0.9	1.7	-1.1	-1.0	-0.9	-0.8	-0.1	-1.3	-1.3	-0.5	-0.3	-1.1
Family relationship satisfaction	1.2	1.5	2.5	-1.6	-1.5	-1.5	-1.5	-0.5	-0.6	-1.6	0.4	-0.7	-1.3
Leg pain on walking	1.4	1.8	6.3	-1.2	-1.1	-1.1	-0.8	-2.5	1.7	-0.7	-1.5	-0.3	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	0.3	0.3	0.3	-0.0	1.1	-0.7	1.0	0.9	-0.5	0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.8	0.6	0.4	0.4	0.6	-0.4	-1.7	0.9	-1.1	-1.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.6	-0.5	-0.3	-0.3	-0.6	1.3	1.0	-0.2	-0.0	0.0	-0.2
Medication: Aspirin	0.7	0.9	2.4	0.7	0.7	0.8	0.3	1.1	1.6	0.6	0.8	1.3	1.1
Supplements: Vitamin C	0.8	1.0	3.5	-0.9	-0.8	-0.7	-0.4	0.8	1.1	-1.9	-1.4	0.2	-0.5
Knee pain experienced in last month	2.0	3.1	10.1	-1.4	-1.5	-1.6	-1.4	-2.8	0.1	-1.3	-3.2	-0.6	-1.5
Hypertension (Self-reported)	0.1	0.3	1.2	0.4	0.4	0.4	0.1	-0.6	-0.5	0.4	1.1	0.6	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.1	0.9	0.9	1.0	0.9	1.4	0.2	0.7	-0.6	1.4	0.9
Illnesses of father: Heart disease	0.4	0.6	2.2	0.8	0.6	0.6	0.2	-1.0	0.4	0.8	1.5	-0.3	0.7
Illnesses of siblings: Diabetes	0.2	0.2	1.2	-0.2	-0.2	-0.2	-0.2	-0.4	-0.6	0.3	0.4	-1.1	-0.3
Smoking status: Previous	0.4	0.6	3.1	-0.5	-0.7	-0.7	-0.8	-1.8	-0.8	-0.0	-0.3	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.8	-0.8	-0.9	-0.9	-1.0	0.6	-1.7	-0.3	-1.1	-0.7	-1.0
Whole body fat-free mass	0.1	0.8	3.8	0.6	0.4	0.4	0.2	-1.1	-1.9	0.8	-1.1	-0.4	0.0
Leg fat-free mass (right)	0.2	0.8	2.3	0.8	0.7	0.7	0.5	-1.2	-1.5	1.0	-1.2	-0.2	0.3
Arm fat percentage (left)	0.3	1.3	2.2	-1.2	-1.3	-1.3	-1.3	-1.3	0.7	-1.0	0.3	-1.5	-1.1
Average weekly red wine intake	0.1	0.2	0.5	-0.6	-0.6	-0.6	-0.3	-0.4	0.3	-0.3	0.6	-0.1	-0.7
Handedness (chirality/laterality): Left-handed	2.2	2.6	4.8	2.1	2.0	1.9	2.0	-0.4	-0.7	2.2	1.0	-0.8	1.8
Mood swings	0.2	0.3	1.7	-0.3	-0.3	-0.3	-0.1	-0.2	-1.3	0.2	-1.1	0.2	-0.3
Loneliness, isolation	0.7	0.9	2.4	-1.0	-1.0	-1.0	-0.8	-0.4	0.2	-0.9	1.6	0.5	-1.1
Long-standing illness, disability or infirmity	0.2	0.3	1.2	-0.2	-0.2	-0.2	-0.3	-0.9	1.1	-0.4	0.4	-0.4	-0.2
Ever had bowel cancer screening	1.6	1.8	3.6	1.0	1.2	1.3	1.0	1.6	1.3	1.1	1.9	1.7	1.2
Diabetes diagnosed by doctor	1.4	2.4	5.1	-1.9	-1.7	-1.7	-1.6	0.4	1.5	-2.3	1.1	-0.8	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	2.6	-1.6	-1.6	-1.6	-1.5	-1.5	1.4	-1.4	0.7	-0.5	-1.5
Friendships satisfaction	0.2	0.2	0.6	-0.3	-0.2	-0.3	-0.2	-0.2	-0.7	-0.8	-0.6	-0.4	-0.2
Qualifications: nursing, teaching	0.6	0.9	3.1	-0.8	-0.7	-0.7	-0.7	0.3	0.6	-1.8	1.4	-0.4	-0.9
Commuting to job workplace: Walk	2.2	2.4	3.8	-1.7	-1.9	-1.9	-1.9	-1.7	0.3	-1.7	-0.4	-0.8	-1.8
Eye problems/disorders: Cataract	0.3	0.3	0.9	0.1	0.2	0.2	0.3	0.7	0.8	-0.5	0.7	-0.9	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.4	-0.7	-0.7	-0.8	-0.3	-0.7	1.2	-0.6	-0.4	0.2	-0.7
Medication for cholesterol	0.3	0.5	2.5	-0.5	-0.6	-0.6	-0.2	-0.6	-0.6	-0.4	-1.6	-0.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	0.6	0.5	0.5	0.7	0.4	-0.3	0.3	0.6	0.7	0.5
Back pain experienced in last month	0.1	0.1	0.2	-0.4	-0.5	-0.5	-0.2	-0.3	0.3	0.1	-0.2	0.4	-0.4
Mineral and other dietary supplements	1.0	1.3	2.0	1.3	1.3	1.3	1.2	1.3	0.5	1.4	0.9	0.2	1.3
Breast cancer (self-reported)	1.3	1.6	4.7	-1.3	-1.0	-1.0	-1.2	1.1	1.2	-2.2	1.5	0.1	-1.1
Asthma (self-reported)	0.1	0.2	1.1	-0.3	-0.4	-0.4	-0.1	-1.1	0.5	0.3	0.5	0.5	-0.1
Osteoporosis (self-reported)	1.1	1.4	2.1	-1.5	-1.4	-1.5	-1.3	-1.0	-0.1	-1.4	1.0	-0.4	-1.3
Osteoarthritis (self-reported)	1.5	1.9	5.4	-1.5	-1.5	-1.5	-1.5	-1.1	2.3	-1.2	-0.7	-0.4	-1.3
Medication: Aspirin	0.5	0.7	2.1	0.2	0.2	0.3	-0.2	1.2	1.4	0.2	0.5	1.4	0.6
Medication: Gliclazide	1.6	1.8	5.5	-1.3	-1.2	-1.2	-0.9	-0.3	2.4	-1.7	1.3	-1.5	-0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.3	-0.2	-0.2	0.0	0.9	-0.0	-0.5	-0.5	0.5	-0.3
Smoking status: Current	0.4	0.7	3.8	-0.5	-0.4	-0.4	-0.2	0.3	1.0	-0.4	-2.0	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	5.4	-2.1	-2.0	-2.0	-1.8	0.4	-0.5	-2.2	-2.3	-0.9	-2.1
Whole body water mass	0.1	0.8	4.1	0.6	0.5	0.5	0.2	-1.1	-2.0	0.9	-1.1	-0.4	0.0
Leg predicted mass (right)	0.2	0.9	2.4	0.8	0.7	0.7	0.6	-1.2	-1.6	1.1	-1.2	-0.3	0.3
Arm fat mass (left)	0.2	1.0	2.2	-0.9	-1.0	-1.0	-1.1	-1.5	0.0	-0.4	0.2	-1.4	-1.0
Number of self-reported non-cancer illnesses	0.4	0.6	3.3	0.1	0.1	0.1	0.1	-0.4	1.6	0.1	1.8	-0.1	0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.5	0.6	0.6	0.4	0.4	0.1	0.1	0.7	0.7	0.7
Miserableness	0.3	0.6	2.4	0.1	0.1	0.1	0.2	-1.2	-1.6	0.8	-0.7	0.9	0.0
Guilty feelings	0.3	0.5	1.4	0.8	0.6	0.6	0.7	-0.6	-0.7	1.2	-0.2	0.3	1.0
Wears glasses or contact lenses	0.9	1.0	5.4	-0.3	-0.4	-0.4	-0.4	-2.3	-1.5	-0.5	1.0	-0.2	-0.5
Ever taken oral contraceptive pill	0.4	0.5	0.9	-0.8	-0.9	-0.9	-0.8	-0.8	-0.1	-0.5	0.5	-0.1	-0.8
Hearing aid user	0.3	0.3	0.7	-0.3	-0.3	-0.3	-0.4	-0.8	-0.8	-0.6	0.7	0.1	-0.5
Mother’s age at death	0.1	0.2	1.3	-0.2	-0.2	-0.1	-0.4	-0.1	0.3	-0.2	0.1	1.1	-0.1
Financial situation satisfaction	0.5	0.6	3.4	0.2	0.3	0.4	0.1	1.1	-0.8	-0.8	-0.3	1.8	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.2	1.1	0.2	0.1	0.1	0.3	-1.1	0.1	-0.0	0.0	0.5	0.1
Commuting to job workplace: Public transport	1.6	1.9	3.2	1.4	1.5	1.5	1.3	0.9	1.8	0.7	1.5	1.0	1.7
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	0.3	0.6	0.6	0.9	1.2	-0.9	0.2	0.9	1.4	0.6
Medication: Blood pressure	0.5	1.0	1.8	1.1	1.1	1.1	0.8	0.9	-0.0	1.1	1.1	-0.7	1.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.7	-0.3	-0.3	-0.3	-0.2	-0.9	1.3	-0.2	-1.0	-1.2	0.0
Supplements: Fish oil (including cod liver oil)	1.2	1.6	6.2	-1.1	-1.2	-1.2	-1.0	-1.1	0.1	-0.7	-2.5	-1.1	-1.3
High cholesterol (Self-reported)	0.3	0.5	3.0	-0.4	-0.3	-0.3	-0.7	0.3	-0.6	-0.8	1.7	0.2	-0.4
Medication: Bendroflumethiazide	0.6	1.0	1.5	0.8	0.9	0.9	0.5	1.2	1.2	1.1	1.2	-0.2	1.2
Medication: Paracetamol	0.2	0.3	0.7	0.6	0.6	0.6	0.6	-0.4	0.8	0.7	-0.1	0.2	0.6
Medication: Lisinopril	0.3	0.4	1.7	0.5	0.3	0.3	0.1	-0.6	-1.0	0.5	-0.3	-1.3	0.1
Medication: Atorvastatin	0.1	0.2	0.8	0.3	0.3	0.3	0.1	-0.9	0.6	-0.2	0.2	-0.1	0.3
Illnesses of father: High blood pressure	0.5	0.7	3.9	0.1	0.2	0.2	0.1	2.0	0.7	0.3	-0.9	1.1	0.3
Alcohol drinker status: Never	0.3	0.4	0.8	0.7	0.7	0.7	0.7	0.0	-0.2	0.9	0.2	0.6	0.7
Ever smoked	0.2	0.4	1.3	-0.3	-0.5	-0.6	-0.6	-1.2	0.1	0.4	-1.0	-0.2	-0.6
Basal metabolic rate	0.1	0.7	3.4	0.3	0.2	0.2	-0.0	-1.3	-1.8	0.7	-1.0	-0.6	-0.2
Leg fat percentage (left)	0.7	2.5	3.3	-1.8	-1.8	-1.8	-1.8	-1.4	1.1	-1.6	0.4	-1.8	-1.6
Arm fat-free mass (left)	0.2	0.8	4.0	0.3	0.2	0.2	-0.1	-1.3	-2.0	0.7	-0.9	-0.6	-0.3
Number of operations (self-reported)	0.8	1.1	1.9	-1.3	-1.3	-1.3	-1.1	-1.4	-0.9	-0.9	0.4	-0.3	-1.2
Average weekly beer plus cider intake	0.3	0.4	2.2	-0.2	-0.2	-0.1	-0.3	1.5	-1.1	-0.6	-0.3	0.4	-0.1
Irritability	0.4	0.6	1.1	-0.9	-0.9	-0.9	-0.9	-1.0	0.1	-0.4	1.0	-0.2	-0.9
Risk taking	1.2	1.7	6.9	-0.8	-0.5	-0.5	-0.5	2.6	2.0	-1.4	1.5	-1.0	-0.3
Ever had prostate specific antigen (PSA) test	4.1	4.7	8.2	-2.2	-2.3	-2.4	-2.4	-2.9	-0.4	-2.2	-1.8	-1.8	-2.4
Fractured/broken bones in last 5 years	0.6	0.8	4.4	0.7	0.7	0.6	0.6	-0.0	-2.1	0.6	-0.5	-1.0	0.6
Age started oral contraceptive pill	1.2	1.5	2.5	1.5	1.5	1.6	1.3	0.5	-0.1	1.2	0.1	1.6	1.5
Diastolic blood pressure, automated reading	0.4	1.2	1.9	1.2	1.3	1.3	0.9	0.7	-0.5	1.4	1.3	0.1	1.2
Ever depressed for a whole week	0.7	0.9	1.9	-0.9	-0.9	-0.9	-1.2	0.2	-1.4	-1.2	-0.1	-0.5	-1.0
Unable to work because of sickness or disability	0.3	0.4	1.1	-0.6	-0.6	-0.6	-0.5	-1.0	-1.0	-0.2	0.2	0.1	-0.7
Commuting to job workplace: Cycle	0.8	1.0	4.9	0.7	0.8	0.8	0.8	0.2	2.2	0.3	0.0	1.5	0.8
Myopia	1.6	2.3	7.7	0.8	1.2	1.2	0.8	2.4	1.3	-0.4	2.8	1.4	1.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.9	-0.3	-0.3	-0.3	0.1	0.9	-0.3	-0.3	-1.4	-0.4	-0.4
Cholesterol lowering medication	0.4	0.6	2.5	-0.7	-0.7	-0.7	-1.1	-0.3	1.6	-0.4	0.3	-0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	-0.6	-0.6	-0.6	-0.5	-1.1	1.0	-0.8	-1.0	-0.4	-0.6
Pain experienced in last month	1.7	2.9	8.3	1.3	1.6	1.6	1.4	2.9	0.8	1.3	2.5	1.0	1.5
Supplements: Calcium	1.1	1.2	2.2	-1.2	-1.2	-1.2	-1.0	-0.5	-0.0	-1.5	0.8	-1.4	-1.1
Basal cell carcinoma (self-reported)	0.7	0.8	2.0	0.9	0.9	0.8	0.7	-1.4	0.4	1.3	0.9	-0.2	0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.6	0.0	-0.2	-0.2	-0.2	-1.5	-0.9	-0.1	-1.0	-1.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.3	1.2	1.3	1.3	1.4	-0.6	0.8	0.2	1.0	1.5	1.4
Heart disease (siblings)	1.1	1.3	2.2	-1.2	-1.3	-1.3	-1.3	-1.5	-0.9	-1.2	-0.1	-0.9	-1.3
Alcohol drinker status: Previous	1.2	1.3	3.1	-1.3	-1.3	-1.3	-1.3	0.1	0.3	-1.3	1.8	-0.7	-1.1
Pack years of smoking	1.7	2.5	5.2	-1.4	-1.4	-1.4	-1.2	-0.5	-1.9	-1.6	-2.1	-2.3	-1.5
Impedance of whole body	0.1	0.4	1.8	-0.7	-0.7	-0.7	-0.6	0.4	-1.3	0.1	0.1	-0.1	-0.7
Leg fat mass (left)	0.5	2.1	3.4	-1.5	-1.6	-1.6	-1.6	-1.8	0.1	-1.2	0.2	-1.9	-1.6
Arm predicted mass (left)	0.2	0.8	4.1	0.1	-0.0	-0.0	-0.3	-1.3	-2.0	0.5	-0.8	-0.7	-0.5