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chr17:75,465,815-77,462,467

Best TWAS P=7.95e-17 · Best GWAS P=2.12e-14 conditioned to 0.731

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	USP36	0.14	0.13	lasso	3	0.13	1.7e-15	7.1	-7.0	2.1e-12	-0.94	0.04	0.96	FALSE
2	GTEx	Brain Cerebellar Hemisphere	USP36	0.50	0.16	enet	20	0.07	5.7e-03	6.8	-7.5	9.6e-14	-0.81	0.05	0.87	FALSE
3	GTEx	Brain Cerebellum	USP36	0.31	0.20	enet	18	0.13	9.7e-05	6.8	-5.7	1.6e-08	-0.77	0.09	0.74	FALSE
4	GTEx	Brain Nucleus accumbens basal ganglia	USP36	0.36	0.23	lasso	5	0.20	4.8e-06	7.6	-7.7	1.3e-14	-0.99	0.02	0.98	FALSE
5	GTEx	Esophagus Mucosa	USP36	0.11	0.04	enet	13	0.06	1.1e-04	7.6	-8.3	7.9e-17	-0.86	0.02	0.97	TRUE
6	GTEx	Esophagus Muscularis	USP36	0.18	0.16	lasso	3	0.08	2.5e-05	7.1	6.3	3.4e-10	0.85	0.04	0.96	FALSE
7	GTEx	Muscle Skeletal	CYTH1	0.13	0.12	lasso	3	0.13	2.5e-12	7.3	7.3	2.0e-13	0.90	0.08	0.92	FALSE
8	GTEx	Nerve Tibial	SYNGR2	0.16	0.05	enet	23	0.05	1.7e-04	-4.8	5.4	6.1e-08	0.12	0.30	0.03	TRUE
9	GTEx	Testis	USP36	0.32	0.24	lasso	6	0.26	6.2e-12	6.4	-7.2	8.5e-13	-0.91	0.10	0.90	FALSE
10	GTEx	Thyroid	USP36	0.21	0.15	enet	45	0.16	1.6e-12	7.0	-7.0	2.6e-12	-0.84	0.27	0.73	FALSE
11	GTEx	Thyroid	CYTH1	0.24	0.07	lasso	11	0.06	3.4e-05	7.2	7.1	1.2e-12	0.84	0.05	0.95	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TIMP2	0.06	0.01	blup	76	0.02	3.4e-03	5.6	-8.0	1.0e-15	-0.65	0.03	0.23	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	USP36	0.04	0.00	blup	57	0.01	2.9e-02	7.6	-6.0	2.3e-09	-0.80	0.01	0.53	FALSE
14	The Cancer Genome Atlas	Testicular Germ Cell Tumors	USP36	0.10	0.02	lasso	4	0.05	6.6e-03	7.5	-5.8	5.8e-09	-0.81	0.02	0.83	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	TIMP2	0.06	0.01	blup	77	0.02	1.2e-02	2.5	5.5	3.9e-08	0.39	0.04	0.17	FALSE