Hub : Genes

TIMP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.146	0.0221	0.0000	0.120	0.067	0.113	0.123	0.117	3.4e-37	4.6e-21	5.9e-35	6.3e-38	3.0e-36
2	TCGA	Bladder Urothelial Carcinoma	0.061	0.0310	0.0039	0.013	0.024	0.013	NA	0.020	2.4e-02	3.4e-03	2.6e-02	NA	7.1e-03
3	TCGA	Thyroid Carcinoma	0.063	0.0290	0.0025	0.010	0.015	0.010	NA	0.013	3.0e-02	1.2e-02	3.0e-02	NA	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.4	-0.5	-0.6	0.4
Bipolar Disorder or Schizophrenia	1.0	2.5	6.2	-0.9	-0.6	-2.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.3	1.1	0.7	0.3
Depression (Nagel 2018)	0.3	0.4	1.1	-0.2	0.1	-1.1
Intelligence (Savage-Jansen 2018)	1.0	3.0	8.5	-0.7	-2.9	0.4
Neuroticism (Nagel 2018)	1.1	2.6	5.0	1.1	2.2	-1.3
Schizophrenia (2018)	2.1	4.3	12.3	-0.8	-0.3	-3.5
Schizophrenia vs Biploar Disorder	0.8	1.1	2.4	-0.4	-0.9	-1.5
Worry (Nagel 2018)	1.7	3.5	7.0	1.0	2.7	-1.6
Alzheimer’s Disease (in mother)	1.5	1.8	3.5	-0.8	1.1	1.9
Alzheimer’s Disease (in father)	1.1	1.2	3.1	1.8	0.1	0.6
Alzheimer’s Disease (including proxy)	1.4	2.1	5.7	0.3	0.7	2.4
Crohns Disease (2017)	0.7	1.5	4.2	-0.5	2.1	0.4
Irritable Bowel Disease (IBD)	2.1	4.9	9.4	-2.0	3.1	-1.1
Ulcerative Colitis (UC)	3.5	6.6	8.1	-2.8	2.7	-2.1
Major Depression (MDD)	0.7	0.8	1.3	0.0	-1.1	-1.1
Reaction Time	1.0	1.8	3.9	0.1	1.2	-2.0
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.8	-0.8	-2.2	-1.3
Breast Cancer	0.6	1.6	3.7	1.9	0.9	0.5
Ovarian Cancer	1.5	2.0	3.8	1.2	1.9	-0.8
Prostate Cancer	1.6	2.3	4.4	-1.5	0.6	-2.1
Age at First Birth	0.5	0.7	2.1	0.2	-1.4	-0.2
Bipolar Disorder (2011)	0.9	0.9	2.5	0.0	-0.5	-1.6
Body Mass Index (BMI) (2010)	0.5	0.6	1.9	0.1	-1.4	-0.2
Coronary Artery Disease (CAD)	0.6	0.7	1.6	0.4	-1.2	-0.5
Crohns Disease (2012)	0.1	0.2	0.4	0.7	0.2	-0.1
Mean Putamen Volume	1.4	1.6	4.3	-0.7	-0.2	-2.1
Fasting Glucose	0.2	0.2	0.6	0.3	-0.2	-0.8
HbA1C	0.6	0.7	1.4	1.2	-0.4	0.7
HDL Cholesterol	3.5	5.8	7.1	2.0	2.7	-2.5
LDL Cholesterol	0.4	0.7	1.6	-1.3	-0.5	0.5
Lupus	0.9	1.3	2.2	1.5	-0.8	1.1
Neuroticism (2016)	1.6	2.3	5.3	2.3	1.1	-0.5
Primary Biliary Cirrhosis	2.3	3.2	5.4	-2.3	1.7	1.2
Rheumatoid Arthritis	1.5	2.0	4.3	0.4	-2.1	-1.3
Schizophrenia (2014)	1.5	3.3	8.1	-1.2	-0.6	-2.8
Triglycerides	2.1	3.4	7.7	0.1	-2.8	1.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	0.8	0.9	-0.7	0.8
Ulcerative Colitis	2.6	3.8	6.7	-1.5	1.5	-2.6
Blood Eosinophil Count	0.2	1.2	3.0	-0.8	-0.1	1.7
Blood Platelet Count	0.0	0.5	0.8	0.6	-0.5	0.9
Blood Red Count	0.5	4.8	12.1	1.2	3.5	-0.9
Blood White Count	0.0	0.3	0.9	0.1	-0.0	0.9
Heel T-Score	2.2	17.8	51.1	-7.2	-0.5	1.4
BMI	0.3	1.7	5.1	2.2	-0.3	0.0
Height	2.6	49.4	84.1	-1.5	-9.2	7.9
Waist Hip Ratio (WHR)	2.2	9.8	21.7	-2.3	-1.6	4.7
Systolic Blood Pressure	2.6	13.0	33.2	-0.9	-5.8	2.3
Smoking Status	1.1	2.6	7.3	2.7	0.6	-0.1
Allergy or Eczema	0.1	0.1	0.2	-0.5	0.1	0.4
Cardiovascular Disease	2.7	9.0	15.1	-0.7	-3.4	3.9
Hypothyroidism (self reported)	0.3	0.6	1.3	-0.6	-1.1	0.2
Respiratory disease	3.5	7.8	20.2	-4.5	-1.7	-0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.6	-1.0	-0.2	1.6
Lung FEV1/FVC ratio	1.3	6.5	13.2	3.6	2.3	0.9
Lung FVC	0.2	1.0	2.0	-0.4	1.4	-1.0
Neuroticism	0.4	0.9	1.6	0.2	1.3	-1.1
Chronotype (morning person)	0.6	1.5	3.4	1.0	1.8	-0.2
Hair Pigment	0.2	5.5	15.7	-0.5	4.0	-0.8
Tanning	0.3	3.9	6.4	2.5	2.2	0.5
Hand grip strength (left)	1.5	4.1	8.1	-0.1	-2.0	2.9
Number of treatments/medications taken	0.2	0.4	0.8	0.1	0.6	0.9
Average weekly spirits intake	0.2	0.3	0.3	0.6	-0.5	0.4
Sensitivity / hurt feelings	0.2	0.4	0.9	-0.0	0.9	-0.6
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.0	-1.4	-0.7	0.5
Hearing difficulty/problems: Yes	0.2	0.3	0.5	-0.7	-0.3	0.4
Relative age of first facial hair	0.1	0.2	0.4	0.6	-0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	3.6	4.6	9.3	-1.7	-3.0	-1.2
Ever used hormone-replacement therapy (HRT)	1.9	2.4	5.5	0.9	2.4	0.8
Ever had hysterectomy (womb removed)	0.9	1.0	1.5	-1.2	1.2	0.3
Systolic blood pressure, automated reading	2.3	6.8	18.6	0.6	-4.3	1.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	2.4	-1.5	-1.6	0.5
Angina	0.1	0.1	0.3	0.6	0.3	-0.1
Medication for hormone replacement therapy	2.4	2.7	5.7	2.4	1.6	0.2
Vitamin and mineral supplements	0.4	0.6	1.0	-1.0	-0.7	0.5
Supplements: Zinc	0.1	0.1	0.2	-0.4	0.0	-0.1
Medication: Co-codamol	0.1	0.2	0.4	-0.3	0.0	-0.6
Medication: Metformin	1.2	1.7	3.4	-1.8	-0.0	1.3
Diabetes (father)	0.1	0.1	0.2	0.1	0.4	0.3
Diabetes (mother)	1.6	2.0	3.6	-1.9	-0.4	1.5
Severe depression (siblings)	0.3	0.4	0.8	-0.3	0.9	0.5
Pack years adult smoking proportion	1.2	1.8	1.9	1.2	-1.4	-1.3
Impedance of leg (right)	0.6	3.1	8.3	-1.0	0.4	2.9
Leg fat-free mass (left)	1.4	7.5	20.6	-0.1	-4.5	1.4
Trunk fat percentage	0.6	2.6	6.0	-0.2	-1.3	2.4
Hand grip strength (right)	1.2	3.3	6.8	0.5	-2.6	1.7
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.4	0.4	0.7
Current tobacco smoking	0.8	1.3	3.6	1.9	0.2	-0.4
Average weekly fortified wine intake	0.0	0.0	0.1	-0.2	0.3	0.0
Maternal smoking around birth	0.2	0.3	0.3	-0.5	0.5	0.5
Fed-up feelings	0.3	0.6	0.9	-0.0	1.0	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.8	-1.3	-0.3	-1.1
Relative age voice broke	1.5	2.3	5.2	1.3	2.3	0.0
Taking other prescription medications	1.7	2.6	7.1	-2.7	0.7	0.1
Age when periods started (menarche)	0.4	1.1	2.3	1.5	0.5	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.9	0.0	0.2	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	6.1	-2.5	-1.7	1.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.7	-0.3	0.8	1.6
Qualifications: CSEs or equivalent	0.3	0.4	0.7	0.3	-0.6	0.9
Serious illness, injury or assault to yourself	0.1	0.2	0.4	0.1	-0.4	-0.6
High blood pressure	1.3	3.7	6.9	-0.9	-1.8	2.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-1.0	0.2	0.5
Multivitamins +/- minerals	0.8	1.1	1.9	0.9	-0.6	-1.4
Stomach or abdominal pain in last month	1.4	1.8	2.4	-0.9	-1.6	1.5
Supplements: Glucosamine	1.3	1.7	2.9	1.7	-1.2	0.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.0	-1.7	-0.5	0.7
Medication: Atenolol	1.2	1.5	2.2	-0.2	1.5	1.5
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.6	-0.7	-0.1
Sitting height	1.0	6.8	16.3	-1.2	-4.0	1.6
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	-1.1	-0.5	-0.8
High blood pressure (mother)	3.4	4.7	6.2	-2.5	-1.6	2.3
Body mass index (BMI)	0.2	0.8	2.0	1.4	-0.0	0.6
Impedance of leg (left)	0.6	3.0	6.0	-1.4	1.1	2.5
Leg predicted mass (left)	1.4	7.6	21.0	-0.1	-4.6	1.3
Trunk fat mass	1.0	4.1	6.6	-0.1	-2.4	2.6
Waist circumference	0.6	2.3	6.6	-0.0	-0.7	2.6
Number of incorrect matches in round	0.8	1.3	2.2	-0.6	1.5	1.1
Past tobacco smoking	0.9	1.7	2.2	-1.4	-1.5	0.9
Alcohol usually taken with meals	0.6	1.0	1.4	-1.2	-0.9	-0.9
Nervous feelings	2.2	4.2	9.7	0.1	3.1	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.7	-1.2	-0.7	-1.6
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.3	0.5	0.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	0.7	-0.1	-0.3
Had menopause	1.1	1.4	3.7	1.9	0.5	0.2
Had other major operations	0.1	0.1	0.4	0.1	-0.2	0.6
Forced vital capacity (FVC)	1.1	4.2	7.8	-1.3	-2.8	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	5.5	-2.3	-2.0	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.4	0.0	-0.5
Qualifications: None of the above	0.7	1.5	2.9	0.8	1.7	-1.0
Financial difficulties in last 2 years	1.2	1.6	3.8	0.9	-1.9	0.3
Mouth/teeth dental problems	1.1	1.8	3.8	-1.0	-1.9	-0.6
Heart attack	0.1	0.2	0.4	0.6	0.1	-0.3
Allergy	1.3	3.1	8.9	3.0	-0.2	-0.6
Pain all over the body in last month	0.8	0.9	2.1	-0.7	1.5	-0.0
Diabetes (self-reported)	0.6	1.0	1.5	-1.2	0.0	1.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.7	1.6	0.8	-0.6
Medication: Ramipril	1.1	1.4	3.8	-0.3	-0.5	2.0
Medication: Simvastatin	0.3	0.4	0.6	0.6	-0.8	0.4
Fluid intelligence score	1.4	3.0	5.1	-0.8	-1.8	-2.3
Illnesses of siblings	3.3	4.6	4.9	2.2	2.0	-2.2
Neuroticism score	0.6	1.3	3.3	-0.1	1.8	-0.7
Weight	1.4	6.6	11.4	0.3	-3.4	2.9
Impedance of arm (right)	1.4	6.6	9.4	-3.1	-1.0	3.1
Arm fat percentage (right)	0.3	1.3	3.8	0.2	-0.2	2.0
Trunk fat-free mass	1.7	9.9	26.6	0.4	-5.2	1.7
Hip circumference	0.3	1.3	3.3	0.4	-1.8	0.7
Time employed in main current job	1.8	2.1	5.0	1.0	2.2	0.6
Alcohol intake versus 10 years previously	0.5	0.7	1.3	-1.1	0.6	-0.8
Father’s age at death	0.5	0.6	1.8	0.4	-1.3	0.1
Worrier / anxious feelings	0.2	0.3	0.5	-0.4	0.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.6	-0.7	-1.6	0.3
Falls in the last year	0.7	0.9	2.4	-0.3	-0.5	1.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	0.2	0.7	-1.1
Number of live births	2.3	3.3	6.2	0.8	1.8	2.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	3.8	-0.3	-2.0	1.5
Pulse rate	0.1	0.2	0.6	-0.4	0.1	-0.8
Happiness	1.2	1.4	2.3	-0.6	-1.2	-1.5
Noisy workplace	1.3	1.6	2.5	0.7	-1.6	1.3
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.4	-1.4	-2.1	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.2	-1.0	-0.2	-1.1
Mouth/teeth dental problems: Dentures	0.6	1.1	2.3	-0.2	0.9	-1.5
Asthma	2.5	4.9	13.8	-3.7	-0.8	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.0	0.4	1.0	1.0
Medication: Cholesterol lowering	1.0	1.5	3.5	0.2	-1.9	1.1
Depression (self-reported)	0.2	0.2	0.5	0.2	-0.7	-0.4
Medication: Lansoprazole	1.5	1.7	2.5	1.4	1.6	0.7
Prospective memory result	1.4	1.7	1.9	-1.4	-1.1	1.4
Lung cancer (father)	0.4	0.4	1.2	0.1	-0.3	1.1
Illnesses of mother	2.5	3.1	7.1	2.7	1.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.1	-0.2	-1.4	1.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.1	0.4	0.3
Impedance of arm (left)	1.5	7.0	13.3	-3.6	-1.0	2.5
Arm fat mass (right)	0.5	2.1	4.3	0.4	-1.3	2.1
Trunk predicted mass	1.7	9.5	25.6	0.4	-5.1	1.7
Standing height	3.3	33.1	64.3	-2.2	-8.0	5.5
Length of working week for main job	0.8	0.9	1.4	-1.0	0.5	1.2
Exposure to tobacco smoke at home	1.0	1.1	1.4	-0.8	1.2	1.1
Breastfed as a baby	0.0	0.0	0.1	0.1	0.2	-0.3
Tense / ‘highly strung’	2.2	3.6	4.6	1.6	2.1	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.0	1.0	-0.6	0.6
Hair/balding pattern: Pattern 4	1.0	2.5	4.5	-1.6	2.1	-0.6
Birth weight of first child	2.1	3.8	5.8	-2.3	-0.4	2.4
Peak expiratory flow (PEF)	1.0	2.3	3.5	0.8	-1.9	1.7
Pulse wave reflection index	0.5	0.6	1.2	0.8	1.1	-0.1
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.3	1.1	-1.0	0.2
Loud music exposure frequency	0.6	0.6	0.8	0.7	0.9	-0.7
Qualifications: O levels/GCSEs or equivalent	2.4	3.9	5.7	-2.4	-2.4	0.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.0	0.3	1.4	1.3
Blood clot in the leg (DVT)	2.5	3.2	5.2	-2.3	-2.1	-0.1
Medication: Paracetamol	0.1	0.2	0.7	-0.1	-0.2	0.8
Headache pain in last month	0.4	0.7	1.1	-1.0	-0.8	0.6
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	6.8	0.3	1.0	-2.6
Glaucoma (self-reported)	0.2	0.2	0.5	-0.1	0.7	-0.2
Gout (self-reported)	0.8	1.1	2.6	1.6	0.2	0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	-0.8	-1.1	-0.0
Medication: Amlodipine	0.3	0.5	1.2	-0.2	-0.3	1.1
Medication: Ventolin 100micrograms inhaler	2.5	3.2	5.0	-2.2	-2.1	-0.7
Birth weight	1.3	2.8	8.2	-0.2	-2.9	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	-0.4	0.1	0.2
High blood pressure (siblings)	3.1	4.5	5.7	-1.6	-2.3	2.4
Forced vital capacity (FVC), Best measure	1.0	3.6	5.1	-1.1	-2.3	2.1
Body fat percentage	0.5	1.9	5.2	0.3	-0.6	2.3
Leg fat percentage (right)	0.7	2.4	3.7	1.7	0.9	1.9
Arm fat-free mass (right)	1.2	6.4	15.8	1.0	-4.0	1.5
Exposure to tobacco smoke outside home	0.4	0.5	1.4	-1.2	0.3	0.1
Comparative body size at age 10	0.1	0.3	0.4	0.6	-0.2	0.6
Number of full brothers	1.2	1.5	2.2	-0.9	-1.5	1.1
Worry too long after embarrassment	0.5	0.8	1.5	-0.4	0.9	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.8	5.4	-1.4	-0.9	-2.3
Wheeze or whistling in the chest in last year	0.8	1.3	3.9	-0.1	-0.4	2.0
Number of children fathered	0.7	0.7	1.5	0.7	-1.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.7	-1.3	-1.0	0.7
Age at first live birth	0.7	1.2	2.6	0.7	-1.6	0.7
Pulse wave peak to peak time	0.3	0.3	0.9	-0.2	-1.0	0.0
Health satisfaction	2.3	3.0	4.8	-0.9	-2.2	-1.8
Shortness of breath walking on level ground	2.4	2.9	6.8	-1.3	-2.6	0.6
Qualifications: College or University degree	0.8	2.6	6.1	-1.3	-2.5	0.1
Eye problems/disorders: None of the above	1.5	1.7	2.8	0.9	-1.7	1.2
Mouth/teeth dental problems: Loose teeth	3.2	3.8	8.8	1.6	0.3	3.0
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.1	0.1	0.4
Medication for pain relief, constipation, heartburn	0.4	0.8	1.2	-0.9	-0.6	-1.1
Neck or shoulder pain in last month	1.2	1.7	3.5	-0.7	-1.9	1.1
Medication: Blood pressure	1.0	1.8	5.3	-0.3	0.2	2.3
Angina (self-reported)	0.1	0.1	0.2	0.3	0.3	-0.4
Migraine (self-reported)	1.7	2.1	5.2	2.3	0.9	-0.6
Medication: Ibuprofen	0.5	0.6	1.2	0.4	1.1	0.8
Medication: Allopurinol	1.2	1.6	4.5	2.1	-0.3	-0.4
Medication: Omeprazole	0.2	0.2	0.3	0.5	0.4	-0.5
Medication: Seretide 50 evohaler	2.8	3.3	5.7	-2.4	-1.1	1.7
Mean time to correctly identify matches	1.1	2.1	3.8	-0.1	1.9	-1.6
Heart disease (mother)	1.5	1.8	4.1	-0.1	-2.0	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	0.7	-1.1	-0.0
Whole body fat mass	0.8	3.2	6.0	0.3	-1.9	2.5
Leg fat mass (right)	0.6	2.3	5.5	0.9	-0.9	2.4
Arm predicted mass (right)	1.2	6.0	15.7	0.9	-4.0	1.2
Pulse rate, automated reading	0.9	3.0	4.4	-1.9	1.0	-2.1
Alcohol intake frequency.	1.0	2.3	4.5	-2.1	1.3	-0.7
Comparative height size at age 10	2.9	15.9	25.7	-2.1	-5.1	4.2
Number of full sisters	0.4	0.5	1.0	-0.6	0.5	1.0
Suffer from ‘nerves’	1.0	1.6	3.2	0.2	1.2	-1.8
Overall health rating	0.1	0.3	0.9	-0.1	1.0	-0.1
Chest pain or discomfort	2.2	3.2	4.2	2.0	-2.0	1.2
Had major operations	0.3	0.3	0.6	0.6	0.8	-0.0
Age at last live birth	1.2	1.8	4.2	0.6	-0.9	2.0
Family relationship satisfaction	0.1	0.1	0.3	0.1	0.2	0.5
Leg pain on walking	2.0	2.4	5.1	-1.5	-0.4	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	1.0	0.1	0.8
Commuting to job workplace: Car/motor vehicle	1.7	1.9	2.5	1.3	1.2	1.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	0.8	0.9	0.7	0.9
Medication: Aspirin	0.3	0.5	1.1	0.3	1.1	0.4
Supplements: Vitamin C	0.8	0.9	2.5	0.5	1.6	-0.1
Knee pain experienced in last month	1.2	1.8	2.6	-0.7	-1.6	1.6
Hypertension (Self-reported)	1.2	3.3	7.1	-0.7	-1.5	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.1	1.4	0.4	1.1
Illnesses of father: Heart disease	0.3	0.4	0.8	0.4	-0.9	-0.5
Illnesses of siblings: Diabetes	1.0	1.2	3.4	0.5	-0.2	1.8
Smoking status: Previous	0.3	0.5	0.6	0.8	0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.1	13.7	-1.7	-2.2	3.7
Whole body fat-free mass	1.6	8.9	24.5	0.2	-5.0	1.5
Leg fat-free mass (right)	1.2	6.4	18.2	-0.3	-4.3	1.0
Arm fat percentage (left)	0.2	0.8	2.3	0.1	-0.2	1.5
Average weekly red wine intake	2.6	3.8	8.1	-1.5	-2.8	1.0
Handedness (chirality/laterality): Left-handed	1.1	1.3	1.8	-1.3	1.4	0.5
Mood swings	0.7	1.3	2.9	0.5	1.7	-0.8
Loneliness, isolation	0.2	0.3	0.3	-0.4	-0.6	-0.6
Long-standing illness, disability or infirmity	1.5	2.4	3.8	-1.9	-1.8	-0.1
Ever had bowel cancer screening	0.3	0.3	0.4	-0.6	-0.5	0.6
Diabetes diagnosed by doctor	0.9	1.5	3.1	-1.1	0.3	1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.9	1.4	0.1	-0.4
Friendships satisfaction	0.2	0.3	0.6	-0.4	-0.8	0.0
Qualifications: nursing, teaching	0.2	0.3	0.9	-0.1	-0.9	-0.0
Commuting to job workplace: Walk	0.5	0.6	1.1	-0.7	-1.1	-0.3
Eye problems/disorders: Cataract	1.1	1.3	2.7	1.7	0.9	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.4	-0.3	0.9	1.9
Medication for cholesterol	0.8	1.3	2.2	-1.2	-0.2	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.5	-0.4	0.9
Back pain experienced in last month	1.6	2.3	3.3	-1.4	-1.3	1.8
Mineral and other dietary supplements	0.0	0.0	0.1	-0.1	-0.2	0.1
Breast cancer (self-reported)	0.8	0.9	2.0	-0.7	0.5	-1.4
Asthma (self-reported)	2.5	4.9	13.8	-3.7	-0.9	-0.4
Osteoporosis (self-reported)	1.3	1.7	2.5	0.5	1.6	-1.5
Osteoarthritis (self-reported)	1.0	1.3	2.7	-1.0	0.3	1.6
Medication: Aspirin	0.2	0.3	0.4	0.3	0.5	0.6
Medication: Gliclazide	0.9	1.0	1.7	-1.2	0.1	-1.3
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	0.7	0.3	-0.8
Smoking status: Current	1.0	1.5	3.4	1.8	0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.7	0.5	0.8	-0.1
Whole body water mass	1.5	8.6	23.8	0.3	-4.9	1.4
Leg predicted mass (right)	1.2	6.5	18.6	-0.3	-4.3	0.9
Arm fat mass (left)	0.5	2.3	4.3	0.3	-1.5	2.1
Number of self-reported non-cancer illnesses	1.4	2.4	4.1	-1.6	-2.0	0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.4	-0.8	-0.2	-1.2
Miserableness	0.3	0.6	1.2	1.1	0.2	0.7
Guilty feelings	1.0	1.6	2.7	0.9	1.7	1.0
Wears glasses or contact lenses	1.0	1.1	3.3	-1.8	0.0	-0.1
Ever taken oral contraceptive pill	2.2	2.5	7.3	-0.4	2.7	0.2
Hearing aid user	1.7	1.9	3.3	-1.8	0.6	-1.4
Mother’s age at death	0.1	0.1	0.3	-0.2	0.0	-0.6
Financial situation satisfaction	0.7	0.9	1.9	-0.6	-1.4	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-1.1	-0.6	-0.8
Commuting to job workplace: Public transport	0.6	0.7	1.2	-0.8	0.4	-1.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.3	-1.1	-0.4	-0.0
Medication: Blood pressure	0.4	0.7	1.2	-1.0	-0.1	1.1
Pain type(s) experienced in last month: Hip pain	2.9	3.6	7.7	-0.3	-2.8	1.7
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	-0.3	0.3	-0.0
High cholesterol (Self-reported)	2.6	4.5	8.3	0.1	-2.3	2.9
Medication: Bendroflumethiazide	0.4	0.5	0.7	-0.8	0.6	0.8
Medication: Paracetamol	0.2	0.3	0.6	0.1	-0.8	0.4
Medication: Lisinopril	0.3	0.4	0.8	0.1	0.6	0.9
Medication: Atorvastatin	0.7	0.8	2.0	-0.6	-0.5	1.4
Illnesses of father: High blood pressure	1.1	1.4	3.4	-0.8	-0.1	1.9
Alcohol drinker status: Never	1.2	1.4	2.1	-1.5	0.8	-1.2
Ever smoked	0.8	1.4	2.1	1.5	1.3	-0.6
Basal metabolic rate	1.5	8.5	22.1	0.2	-4.7	1.9
Leg fat percentage (left)	0.5	1.8	2.1	1.4	1.2	1.4
Arm fat-free mass (left)	1.5	7.5	17.2	0.9	-4.2	2.1
Number of operations (self-reported)	0.1	0.2	0.3	0.0	-0.5	0.5
Average weekly beer plus cider intake	1.2	1.8	5.1	2.3	0.5	0.1
Irritability	1.0	1.7	4.6	0.3	2.2	-0.5
Risk taking	0.5	0.7	1.7	-0.6	-1.3	0.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	-0.5	-0.7	-1.3
Fractured/broken bones in last 5 years	0.0	0.1	0.1	0.2	-0.3	0.2
Age started oral contraceptive pill	0.2	0.3	0.3	-0.6	0.6	0.4
Diastolic blood pressure, automated reading	1.5	4.5	11.7	-0.7	-3.4	1.2
Ever depressed for a whole week	0.4	0.5	0.7	-0.8	0.3	-0.8
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.3	0.4	-0.8
Commuting to job workplace: Cycle	0.6	0.7	1.2	-0.8	-0.7	-1.1
Myopia	1.5	2.2	6.0	-0.5	-2.4	0.6
Vascular/heart problems diagnosed by doctor	0.8	2.3	5.1	0.5	1.2	-2.3
Cholesterol lowering medication	0.7	1.0	1.2	0.9	-1.0	1.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	0.7	0.4	-0.4
Pain experienced in last month	3.2	5.3	8.4	1.6	2.2	-2.9
Supplements: Calcium	0.2	0.2	0.4	0.4	0.6	-0.4
Basal cell carcinoma (self-reported)	1.4	1.6	4.1	-0.9	2.0	-0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	0.9	0.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	2.6	3.4	5.6	-2.4	-2.1	-0.2
Heart disease (siblings)	0.6	0.7	1.1	-1.0	0.1	1.1
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.6	-0.8	0.0
Pack years of smoking	1.3	1.9	2.3	1.5	-1.5	-1.0
Impedance of whole body	1.0	5.2	7.9	-2.7	-0.4	2.8
Leg fat mass (left)	0.5	1.8	4.3	0.7	-0.8	2.1
Arm predicted mass (left)	1.4	7.1	16.6	0.9	-4.1	1.9