TWAS hub - CYTH1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1060	0.035	2.5e-03	0.045	0.024	0.058	0.046	0.047	3.3e-06	5.4e-04	1.3e-07	2.4e-06	2.1e-06
2	GTEx	Adipose Subcutaneous	0.1250	0.042	9.2e-04	0.029	NA	0.013	NA	0.036	2.0e-03	NA	2.7e-02	NA	5.8e-04
3	GTEx	Muscle Skeletal	0.1318	0.032	3.2e-08	0.118	NA	0.122	NA	0.126	1.2e-11	NA	5.7e-12	NA	2.5e-12
4	GTEx	Thyroid	0.2450	0.055	2.5e-07	0.069	NA	0.042	NA	0.057	5.4e-06	NA	3.4e-04	NA	3.4e-05
5	YFS	Blood	0.0293	0.013	1.0e-02	0.005	0.002	0.001	0.004	0.003	5.3e-03	8.7e-02	1.5e-01	9.7e-03	2.5e-02
6	TCGA	Thyroid Carcinoma	0.1060	0.037	4.6e-08	0.087	0.078	0.066	NA	0.082	8.1e-09	4.4e-08	5.1e-07	NA	2.4e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Shortness of breath walking on level ground	7.8	9.3	18.3	-0.7	3.8	4.3	3.9	1.4	2.4
Pain experienced in last month	6.8	11.4	19.1	-2.6	-4.4	-3.7	-4.0	-0.9	-3.3
Systolic Blood Pressure	6.3	31.6	60.5	1.0	6.8	7.1	7.8	0.3	5.6
Pain type(s) experienced in last month: Hip pain	6.1	7.7	15.4	0.0	3.3	3.7	3.9	1.8	1.9
Systolic blood pressure, automated reading	6.0	17.5	32.3	1.3	5.2	5.4	5.7	2.1	3.3
High blood pressure (siblings)	6.0	8.6	16.2	0.9	3.9	3.5	4.0	0.2	2.7
Cardiovascular Disease	5.4	17.8	35.4	1.4	5.2	6.0	5.2	0.1	4.0
Chest pain or discomfort	5.4	7.8	15.9	-0.9	2.8	4.0	4.0	2.1	1.4
Average weekly red wine intake	5.4	8.0	13.5	-1.0	3.3	3.7	3.6	1.3	2.9
Back pain experienced in last month	5.1	7.5	11.3	2.9	3.4	2.6	2.8	-0.8	3.1
Medication for hormone replacement therapy	5.0	5.6	8.9	-0.5	-3.0	-2.6	-2.8	-2.0	-2.4
Ever taken oral contraceptive pill	4.9	5.4	9.6	-1.1	-2.8	-2.8	-3.1	-0.5	-2.5
Medication: Ramipril	4.6	5.9	13.7	1.1	2.6	2.8	3.7	0.2	2.4
High blood pressure (mother)	4.4	6.2	12.8	0.3	3.6	3.3	2.7	-0.2	2.4
Illnesses of siblings	4.3	6.0	11.8	-0.7	-3.4	-3.1	-3.3	-0.2	-1.7
Illnesses of mother	4.1	5.1	10.1	-0.5	-3.2	-2.7	-2.6	0.3	-2.4
Diastolic blood pressure, automated reading	3.7	11.6	20.4	0.5	4.4	4.5	4.5	1.8	2.5
Medication: Metformin	3.6	5.1	9.2	1.5	3.0	1.9	1.8	-2.2	2.7
Leg fat-free mass (left)	3.5	18.5	38.9	-2.2	5.1	6.2	5.5	1.9	2.8
Leg predicted mass (left)	3.5	18.5	38.8	-2.2	5.1	6.2	5.5	2.0	2.8
Basal metabolic rate	3.5	19.5	41.3	-2.1	5.1	6.4	5.6	2.2	3.0
Trunk fat-free mass	3.4	19.2	41.1	-2.5	4.8	6.4	5.6	2.3	3.0
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.1	14.7	0.0	3.0	2.7	2.9	-1.7	3.8
Whole body fat-free mass	3.4	19.7	42.0	-2.3	5.0	6.5	5.7	2.2	3.0
Arm fat-free mass (left)	3.4	17.2	37.1	-1.3	4.6	6.1	5.3	2.7	2.8
Ever used hormone-replacement therapy (HRT)	3.3	4.2	10.5	-1.0	-2.8	-1.7	-1.7	0.3	-3.2
Weight	3.3	16.0	32.6	-0.6	5.0	5.7	5.0	2.4	2.7
Whole body water mass	3.3	19.0	40.4	-2.4	4.9	6.4	5.5	2.2	2.9
Coronary Artery Disease (CAD)	3.2	3.8	6.6	0.4	2.3	2.6	1.9	2.3	1.4
Nervous feelings	3.2	6.0	13.0	1.4	-2.4	-3.5	-3.6	-1.2	-1.0
Trunk predicted mass	3.2	18.5	39.6	-2.4	4.7	6.3	5.5	2.2	3.0
Pulse wave reflection index	3.2	3.9	8.5	-0.9	-2.5	-2.1	-2.9	0.1	-2.0
Medication for cholesterol, blood pressure or diabetes	3.2	5.4	10.4	-1.0	-3.2	-2.9	-2.8	0.1	-2.1
Arm fat-free mass (right)	3.2	16.3	34.7	-1.6	4.5	5.9	5.2	2.2	2.9
Knee pain experienced in last month	3.2	5.0	9.4	0.6	2.7	3.1	3.0	1.2	1.7
Arm predicted mass (left)	3.2	16.3	35.3	-1.3	4.5	5.9	5.1	2.5	2.8
Ulcerative Colitis (UC)	3.1	5.8	11.9	2.5	-2.0	-3.0	-3.5	-1.8	-0.0
High cholesterol (Self-reported)	3.1	5.5	10.6	-0.2	3.2	3.3	2.9	-0.1	1.8
Diabetes (mother)	3.0	3.9	5.9	2.2	1.9	1.8	2.4	-1.1	2.0
Leg predicted mass (right)	3.0	15.8	33.2	-2.4	4.6	5.8	5.0	1.8	2.5
Irritable Bowel Disease (IBD)	2.9	6.9	11.6	2.6	-2.5	-3.3	-3.4	-2.2	-0.6
Leg fat-free mass (right)	2.9	15.8	33.3	-2.4	4.6	5.8	5.0	1.8	2.5
Exposure to tobacco smoke outside home	2.8	3.7	5.8	2.2	1.6	1.2	1.6	-2.4	2.2
Arm predicted mass (right)	2.8	14.3	31.4	-1.5	4.1	5.6	4.8	2.2	2.6
Standing height	2.7	26.6	54.0	-3.0	5.0	7.3	7.1	0.4	4.6
Medication: Seretide 50 evohaler	2.7	3.1	4.0	1.7	2.0	1.1	1.7	-1.8	2.0
Leg fat mass (right)	2.7	10.3	18.0	1.6	4.2	4.2	3.6	2.5	2.1
Irritability	2.7	4.7	7.8	-0.1	-2.3	-2.6	-2.8	0.9	-2.7
Relative age voice broke	2.6	4.0	6.5	1.1	-2.5	-2.1	-2.3	1.3	-2.2
Trunk fat mass	2.6	11.2	20.5	0.7	4.5	4.5	4.1	1.8	2.5
Whole body fat mass	2.6	10.7	19.0	0.9	4.4	4.4	4.0	2.2	2.2
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	5.6	-0.1	2.0	2.4	1.9	1.0	2.2
High blood pressure	2.5	6.9	12.1	1.4	3.1	3.5	3.1	0.1	2.8
Mouth/teeth dental problems	2.5	3.9	6.7	-0.5	2.6	1.9	2.6	0.8	2.4
Breastfed as a baby	2.5	3.1	5.7	-2.4	-1.8	-1.0	-1.4	1.5	-2.1
Heart disease (mother)	2.5	3.0	6.6	-1.5	2.0	2.6	2.2	0.5	0.8
Ulcerative Colitis	2.4	3.5	9.4	1.0	-1.7	-2.7	-3.1	-0.8	-0.1
Qualifications: A levels/AS levels or equivalent	2.4	5.2	9.2	-0.8	3.0	2.7	2.5	-0.6	2.8
Age at last live birth	2.4	3.4	7.2	-0.6	2.0	2.1	2.7	-0.9	1.9
Illnesses of siblings: Diabetes	2.4	3.0	5.8	1.2	2.4	1.8	2.3	0.2	1.4
Breast cancer (self-reported)	2.4	2.8	7.6	2.8	-0.4	-1.8	-1.7	-1.2	1.2
Leg fat mass (left)	2.4	9.3	16.5	1.6	4.1	3.9	3.4	2.4	2.0
Prostate Cancer	2.3	3.2	6.5	-1.1	-1.9	-2.4	-2.5	-0.7	-1.2
Age at first live birth	2.3	4.0	6.1	-1.4	2.5	2.3	2.5	-0.1	2.2
Neuroticism (2016)	2.2	3.2	5.2	-0.4	-2.2	-2.3	-2.1	0.7	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	5.1	2.3	1.8	1.2	1.0	0.2	2.1
Comparative height size at age 10	2.2	11.9	27.8	-1.2	3.4	4.6	5.3	0.5	3.0
Hypertension (Self-reported)	2.2	6.1	10.9	1.4	2.9	3.3	3.0	-0.1	2.4
Arm fat mass (left)	2.2	9.0	16.8	0.5	4.0	4.1	3.6	2.2	1.7
Myopia	2.2	3.2	5.7	-0.7	1.9	2.0	2.4	-0.7	2.2
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	4.8	0.0	2.2	1.9	1.8	1.1	1.1
Past tobacco smoking	2.1	3.8	8.3	1.7	2.3	1.3	1.6	-1.4	2.9
Medication: Blood pressure	2.1	3.6	6.0	1.5	2.3	2.3	2.5	0.3	1.8
Supplements: Vitamin C	2.1	2.5	5.0	0.2	-2.2	-1.9	-2.2	0.2	-1.2
Number of self-reported non-cancer illnesses	2.1	3.6	5.7	1.4	2.4	2.0	2.1	-0.4	2.2
Stomach or abdominal pain in last month	2.0	2.4	5.2	0.3	2.3	1.8	1.7	0.7	1.6
Arm fat mass (right)	2.0	8.4	15.8	0.6	4.0	3.9	3.4	2.2	1.6
Eye problems/disorders: None of the above	2.0	2.3	6.8	-2.6	1.0	1.5	1.8	0.5	0.3
Mouth/teeth dental problems: Loose teeth	2.0	2.4	4.2	1.7	1.6	1.8	2.0	1.1	0.5
Worry (Nagel 2018)	1.9	4.0	9.4	1.2	-1.5	-2.7	-3.1	-1.8	-0.9
Height	1.9	37.5	83.2	-2.1	5.8	9.1	8.2	2.9	5.4
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	6.4	0.3	2.5	2.2	1.6	0.3	2.1
Peak expiratory flow (PEF)	1.9	4.3	11.9	-3.5	1.3	2.5	2.4	0.6	0.1
Average weekly champagne plus white wine intake	1.9	2.6	7.5	-2.7	-1.2	-0.7	-1.6	-1.0	-1.6
Ever smoked	1.9	3.3	6.0	-1.7	-2.3	-1.1	-1.7	1.2	-2.4
Smoking Status	1.8	4.2	8.0	-2.5	-2.6	-0.6	-0.9	1.8	-2.8
Hand grip strength (right)	1.8	4.8	10.5	-1.5	2.1	3.1	3.2	-0.1	1.5
Hip circumference	1.8	7.9	18.4	0.6	4.3	3.7	3.2	1.1	2.0
Falls in the last year	1.8	2.4	3.8	1.5	1.6	1.8	1.9	-1.0	1.4
Loud music exposure frequency	1.8	1.9	4.8	-0.4	-1.8	-1.2	-2.2	1.0	-1.0
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.3	-1.2	2.3	2.1	1.6	0.5	1.8
Health satisfaction	1.8	2.4	2.9	-1.7	1.5	1.7	1.5	1.7	1.1
Migraine (self-reported)	1.8	2.3	3.8	-1.9	-1.9	-1.2	-1.6	0.2	-1.4
Long-standing illness, disability or infirmity	1.8	2.7	4.6	0.8	2.1	2.1	1.9	1.0	1.6
Eye problems/disorders: Cataract	1.8	2.1	3.9	1.7	-1.5	-2.0	-1.5	-0.4	-1.0
Vascular/heart problems diagnosed by doctor	1.8	4.8	8.4	-1.6	-2.5	-2.9	-2.6	-0.2	-2.2
Type 2 Diabetes (T2D) (2012)	1.7	2.0	4.9	1.2	2.2	1.4	1.2	0.3	1.5
Respiratory disease	1.7	3.9	8.9	2.7	0.8	-0.7	-0.6	-3.0	2.4
Lung FVC	1.7	8.9	16.0	-2.0	-3.2	-3.5	-4.0	-2.1	-2.5
Qualifications: None of the above	1.7	3.7	5.2	2.3	-1.9	-2.3	-1.9	-1.0	-1.8
Diabetes (self-reported)	1.7	2.6	6.4	0.7	2.5	1.9	1.6	-0.6	1.4
Mouth/teeth dental problems: Dentures	1.7	2.9	7.5	0.1	-2.2	-1.3	-1.8	0.7	-2.7
Prospective memory result	1.7	2.0	3.7	1.7	1.3	0.7	0.7	-1.7	1.9
Exposure to tobacco smoke at home	1.7	1.9	3.4	0.7	-1.5	-1.9	-1.4	-1.3	-1.4
Qualifications: College or University degree	1.7	5.5	9.4	-0.8	2.5	2.8	3.1	-0.2	2.9
Diabetes diagnosed by doctor	1.7	2.8	6.4	0.8	2.5	2.1	1.9	-0.2	1.4
Crohns Disease (2017)	1.6	3.5	5.6	2.4	-1.8	-2.2	-1.9	-1.8	-0.7
HDL Cholesterol	1.6	2.7	4.6	0.5	-2.2	-1.7	-1.4	1.9	-1.5
Type 2 Diabetes (T2D) (2018)	1.6	3.0	6.5	1.0	2.6	2.2	1.9	-0.2	1.5
Medication: Cholesterol lowering	1.6	2.5	4.8	-1.5	2.2	2.0	1.8	0.2	0.8
Suffer from ‘nerves’	1.6	2.5	7.2	0.6	-1.1	-2.1	-2.7	-1.3	0.1
Qualifications: nursing, teaching	1.6	2.4	4.1	-0.8	1.7	2.0	1.4	1.1	1.9
Asthma (self-reported)	1.6	3.2	7.3	2.7	1.2	-0.4	-0.3	-2.4	2.2
Alcohol drinker status: Previous	1.6	1.8	4.5	0.0	1.5	1.9	2.1	0.0	0.7
Neuroticism (Nagel 2018)	1.5	3.6	8.7	1.0	-1.5	-2.6	-3.0	-0.8	-1.6
Reaction Time	1.5	2.9	6.5	1.1	-0.9	-2.0	-2.5	-2.2	0.0
Mean Putamen Volume	1.5	1.8	3.3	-0.7	-1.6	-1.8	-1.6	-1.0	-0.8
Primary Biliary Cirrhosis	1.5	2.1	5.2	1.7	-1.3	-2.3	-1.6	0.0	-0.2
Hand grip strength (left)	1.5	3.8	9.4	-0.6	1.8	2.6	3.1	-0.3	1.7
Trunk fat percentage	1.5	5.9	12.0	1.3	3.5	3.0	2.9	1.1	1.7
Alcohol intake versus 10 years previously	1.5	2.3	6.7	2.6	0.3	-1.3	-1.2	-1.9	0.8
Noisy workplace	1.5	1.8	3.1	-1.0	1.8	1.4	1.7	-0.6	1.3
Medication: Amlodipine	1.5	2.1	4.6	-0.2	1.5	1.6	2.1	1.3	1.1
Birth weight	1.5	3.2	6.1	-1.4	1.4	2.4	2.5	1.7	1.0
Wheeze or whistling in the chest in last year	1.5	2.6	7.0	0.3	1.6	2.6	2.1	1.1	0.2
Pulse wave peak to peak time	1.5	1.8	3.6	0.3	1.7	1.1	1.9	-0.2	1.7
Age at First Birth	1.4	2.0	4.6	0.6	1.3	1.7	2.1	-0.4	1.6
Number of incorrect matches in round	1.4	2.3	9.9	3.2	0.8	0.2	0.1	-1.4	1.2
Pain all over the body in last month	1.4	1.6	3.5	0.4	-1.9	-1.5	-1.4	-0.0	-1.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	6.8	-1.3	-1.1	-0.4	-0.2	2.6	-1.2
Number of live births	1.4	2.0	4.8	-1.0	-2.2	-1.0	-0.8	0.4	-2.0
Asthma	1.4	2.8	7.0	2.6	1.0	-0.5	-0.5	-2.1	1.9
Body fat percentage	1.4	5.7	11.4	1.6	3.4	2.9	2.7	1.6	1.5
Worry too long after embarrassment	1.4	2.4	4.6	0.0	-1.3	-2.2	-2.1	-1.6	-0.9
Smoking status: Current	1.4	2.2	4.9	-1.2	-1.9	-0.7	-1.1	1.2	-2.2
Eye problems/disorders: Glaucoma	1.4	1.7	3.4	1.8	1.5	0.9	0.9	-0.3	1.6
Cholesterol lowering medication	1.4	2.0	3.5	1.4	1.9	1.8	1.2	1.0	0.9
Ovarian Cancer	1.3	1.8	3.7	0.1	-1.1	-1.8	-1.5	-1.9	-0.4
BMI	1.3	7.3	13.7	0.5	3.6	3.7	2.4	3.2	0.8
Angina	1.3	1.7	4.2	0.1	0.4	1.6	1.8	2.1	-0.1
Supplements: Glucosamine	1.3	1.8	3.2	-0.1	1.6	1.8	1.8	-0.1	1.3
Waist circumference	1.3	4.8	9.9	0.4	2.6	3.2	2.8	1.8	0.9
Arm fat percentage (right)	1.3	5.3	11.5	1.3	3.4	2.8	2.4	1.9	1.1
Mean time to correctly identify matches	1.3	2.5	4.5	1.9	-0.8	-1.7	-2.1	-1.8	-0.2
Supplements: Fish oil (including cod liver oil)	1.3	1.6	7.8	-0.2	-0.3	-1.0	-1.0	-2.8	0.3
Schizophrenia vs Biploar Disorder	1.2	1.6	3.0	-1.7	-1.6	-1.4	-1.1	-0.4	-0.9
Blood Red Count	1.2	11.1	19.2	0.2	-4.2	-4.4	-3.9	-2.5	-3.0
Financial difficulties in last 2 years	1.2	1.7	2.9	-1.3	1.7	1.5	1.1	0.8	1.1
Hair/balding pattern: Pattern 4	1.2	3.0	6.9	2.6	-1.4	-2.2	-1.9	-0.7	-0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.0	0.8	-1.5	-1.4	-1.1	-1.7	-0.3
Leg fat percentage (right)	1.2	4.3	6.5	2.4	2.5	2.1	1.8	2.3	0.8
Medication: Allopurinol	1.2	1.6	3.5	-1.6	-0.9	-1.3	-1.1	0.6	-1.9
Number of full sisters	1.2	1.5	3.1	1.0	1.2	1.7	1.8	-0.7	0.2
Arm fat percentage (left)	1.2	4.6	10.1	1.3	3.2	2.6	2.3	1.7	0.9
Mood swings	1.2	2.1	5.0	1.3	-0.9	-1.7	-2.2	-0.7	-1.4
Medication: Lisinopril	1.2	1.5	4.3	2.1	1.2	0.7	0.5	0.1	1.6
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.1	-1.4	-1.4	-1.0	-1.4	1.1	-0.5
HbA1C	1.1	1.2	3.5	-0.5	0.6	1.3	0.9	1.9	0.6
Medication: Co-codamol	1.1	1.3	3.0	-1.5	-0.8	-0.3	-0.4	1.7	-1.3
Current tobacco smoking	1.1	1.8	3.3	-1.6	-1.4	0.1	-0.6	1.5	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	12.3	-0.1	1.0	0.5	0.5	-3.5	1.1
Body mass index (BMI)	1.1	4.7	9.1	0.7	3.0	2.8	2.1	2.5	0.8
Headache pain in last month	1.1	1.9	3.4	1.4	1.8	1.3	1.3	0.6	1.6
Comparative body size at age 10	1.1	3.2	6.6	0.7	2.1	2.6	2.0	0.4	1.8
Number of full brothers	1.1	1.4	3.6	-0.1	1.9	1.2	1.1	0.2	1.4
Angina (self-reported)	1.1	1.4	3.8	-0.1	0.3	1.5	1.5	1.9	-0.2
Had major operations	1.1	1.3	4.2	-2.0	-1.2	-0.7	-0.3	-0.4	-1.2
Intelligence (Savage-Jansen 2018)	1.0	3.0	6.0	0.3	2.4	2.1	2.0	-0.8	1.7
Heel T-Score	1.0	8.2	35.3	1.1	-0.4	-2.3	-1.8	-5.9	2.1
Hair/balding pattern: Pattern 3	1.0	1.4	4.1	-0.7	-2.0	-0.9	-1.3	-0.4	-1.2
Financial situation satisfaction	1.0	1.3	2.3	1.3	0.9	1.2	0.6	1.5	1.1
Leg fat percentage (left)	1.0	3.7	6.4	2.5	2.3	1.8	1.4	2.3	0.7
Alzheimer’s Disease (in father)	0.9	1.0	2.1	-0.5	0.4	1.5	1.0	1.4	-0.4
Lupus	0.9	1.3	2.8	0.6	1.1	1.7	1.4	0.7	0.9
Schizophrenia (2014)	0.9	2.0	3.8	-1.7	-1.9	-1.4	-1.6	-0.6	-0.6
Triglycerides	0.9	1.5	3.6	-0.8	1.9	1.5	1.0	-0.6	1.3
Ever had hysterectomy (womb removed)	0.9	1.0	1.8	0.8	-0.5	-1.3	-1.2	-0.6	-1.1
Diabetes (father)	0.9	1.1	3.3	1.2	1.8	1.0	0.6	-0.3	0.6
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.4	0.1	1.2	1.0	1.1	-1.2	1.1
Medication: Atenolol	0.9	1.1	3.2	-0.2	-1.3	-0.7	-1.1	0.2	-1.8
Sitting height	0.9	6.2	13.2	-2.1	2.4	3.6	3.2	0.5	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	9.7	0.5	0.9	0.3	0.1	-3.1	1.2
Medication: Simvastatin	0.9	1.3	2.7	0.2	1.6	1.5	1.1	1.1	0.8
Time employed in main current job	0.9	1.0	2.8	1.4	-0.9	-0.8	-0.1	-1.7	-0.2
Pulse wave Arterial Stiffness index	0.9	1.0	1.9	-0.5	-1.3	-0.6	-1.4	0.2	-1.3
Medication for pain relief, constipation, heartburn	0.9	1.5	2.3	-1.5	-1.1	-1.3	-0.9	-1.4	-1.1
Loneliness, isolation	0.9	1.3	2.6	1.3	1.6	0.3	0.6	-1.1	1.4
Friendships satisfaction	0.9	1.2	2.6	1.6	1.2	0.8	0.7	0.2	1.3
Hearing aid user	0.9	1.1	2.2	1.5	-0.8	-1.2	-1.3	0.0	0.6
Fractured/broken bones in last 5 years	0.9	1.1	3.7	-0.3	0.2	1.1	1.4	1.9	0.0
Blood White Count	0.8	5.9	14.4	3.0	1.8	2.1	1.9	-0.5	3.8
Neuroticism	0.8	2.0	4.5	0.5	-1.2	-2.1	-2.1	-0.7	-1.0
Hearing difficulty/problems with background noise	0.8	1.3	2.8	-1.3	-0.6	-0.8	-1.4	0.3	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.5	-0.2	0.8	1.6	1.1	1.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	-1.3	0.8	0.7	1.0	1.3	0.1
Smoking status: Previous	0.8	1.1	2.6	-1.1	-1.2	-0.6	-0.6	0.9	-1.6
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.7	-0.3	-1.0	-1.1	-1.3	0.3	-1.2
Commuting to job workplace: Walk	0.8	0.9	4.2	0.5	0.1	-0.1	0.2	-2.0	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.6	1.3	1.1	1.1	0.8	0.5	1.0
Mineral and other dietary supplements	0.8	1.1	5.6	-0.4	-0.0	-0.1	0.3	2.4	-0.7
Osteoporosis (self-reported)	0.8	0.9	1.5	1.2	-1.0	-1.2	-1.2	0.7	-0.3
Schizophrenia (2018)	0.7	1.4	3.0	-1.5	-1.7	-1.2	-1.2	-0.2	-0.5
Crohns Disease (2012)	0.7	1.0	1.3	1.2	-1.1	-1.1	-1.1	-1.1	0.3
Rheumatoid Arthritis	0.7	0.9	2.6	-0.9	0.3	1.3	0.3	1.6	0.4
Hearing difficulty/problems: Yes	0.7	1.0	1.9	-1.3	-0.7	-0.5	-1.0	0.7	-1.4
Fed-up feelings	0.7	1.3	3.0	0.9	-0.3	-1.4	-1.7	-1.2	-0.8
Taking other prescription medications	0.7	1.0	3.5	1.9	-0.2	-0.7	-1.0	-1.1	0.1
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.9	1.2	1.4	0.8	1.2	-0.4	1.7
Impedance of leg (left)	0.7	3.4	6.4	2.5	-1.6	-2.2	-1.3	-2.1	0.8
Had menopause	0.7	0.8	1.9	0.5	-1.0	-0.7	-0.8	0.9	-1.4
Allergy	0.7	1.6	4.6	-2.1	-0.7	-0.0	-0.2	1.2	-1.6
Neuroticism score	0.7	1.5	2.7	1.5	-0.4	-1.7	-1.6	-1.0	-0.2
Worrier / anxious feelings	0.7	1.3	3.8	1.9	0.6	-0.6	-0.6	-1.1	1.3
Pulse rate	0.7	1.2	2.0	-0.6	1.2	1.3	1.3	0.1	1.4
Lung cancer (father)	0.7	0.8	2.0	-1.4	-0.4	-0.0	-0.5	0.7	-1.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.7	-0.8	-0.7	-0.5	-0.9	1.3	-0.9
Medication: Aspirin	0.7	1.0	2.8	0.7	0.6	1.1	0.9	1.7	-0.3
Bipolar Disorder (2018)	0.6	1.0	1.8	0.2	0.9	1.3	1.3	-0.2	1.3
Body Mass Index (BMI) (2010)	0.6	0.8	2.3	0.6	1.5	0.7	0.4	-0.3	1.0
Number of treatments/medications taken	0.6	1.0	1.7	1.3	1.3	0.8	0.4	-0.9	1.2
Supplements: Zinc	0.6	0.6	1.6	-0.1	1.1	1.3	0.8	0.3	0.6
Severe depression (siblings)	0.6	0.7	2.9	1.7	-0.6	-0.5	-0.1	-0.5	-0.6
Glaucoma (self-reported)	0.6	0.7	1.4	1.0	0.9	0.6	1.2	0.1	0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.5	0.4	1.1	0.6	0.5	-0.9	1.2
Medication: Omeprazole	0.6	0.7	1.3	0.7	-0.6	-1.1	-0.6	-0.8	-1.0
Sensitivity / hurt feelings	0.5	0.8	4.5	2.1	0.4	-0.1	0.3	-0.2	0.2
Impedance of leg (right)	0.5	2.5	5.5	2.3	-1.0	-1.6	-0.8	-2.0	1.1
Average weekly fortified wine intake	0.5	0.6	1.1	0.6	-0.5	-1.1	-0.9	-0.8	0.5
Qualifications: CSEs or equivalent	0.5	0.6	1.2	-0.9	0.5	0.4	0.6	1.1	0.9
Serious illness, injury or assault to yourself	0.5	0.6	1.0	0.8	-1.0	-0.7	-0.6	0.6	-1.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.9	-1.4	-0.0	0.6	0.1	-0.1	-1.1
Forced vital capacity (FVC)	0.5	2.1	6.6	-2.6	0.5	1.0	0.9	-1.8	0.7
Father’s age at death	0.5	0.6	1.2	-1.1	0.9	1.0	0.7	-0.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	5.1	-2.2	0.7	1.2	1.1	-1.3	0.8
Medication: Lansoprazole	0.5	0.5	1.6	0.3	0.4	0.8	0.5	1.3	-0.5
Length of working week for main job	0.5	0.6	1.8	-0.5	0.4	1.3	1.0	0.3	0.6
Tense / ‘highly strung’	0.5	0.9	2.7	0.6	-0.9	-0.6	-0.5	-0.8	-1.7
Medication: Paracetamol	0.5	0.8	2.1	1.4	0.7	0.4	0.3	0.2	1.3
Neck or shoulder pain in last month	0.5	0.7	1.8	-0.0	1.1	1.3	0.8	0.4	0.3
Overall health rating	0.5	1.0	3.3	1.8	1.0	0.9	0.1	0.6	0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-0.4	-0.9	-0.6	-0.5	-1.4	-0.1
Commuting to job workplace: Public transport	0.5	0.5	1.3	0.2	-1.1	-1.0	-0.4	-0.8	-0.5
Medication: Bendroflumethiazide	0.5	0.8	2.4	0.8	0.5	-0.7	-1.0	-1.6	-0.3
Medication: Atorvastatin	0.5	0.6	1.5	0.5	1.2	1.0	0.7	-0.4	0.5
Age started oral contraceptive pill	0.5	0.6	3.3	1.8	-0.0	-0.4	-0.1	0.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	0.9	-0.7	-0.9	-0.4	-0.6	-1.0
Basal cell carcinoma (self-reported)	0.5	0.5	2.0	1.4	-0.2	-0.4	-0.0	-1.0	0.2
Impedance of whole body	0.5	2.6	7.6	1.9	-0.9	-1.6	-0.5	-2.8	0.9
Depressed Affect (Nagel 2018)	0.4	0.9	1.9	1.2	-0.1	-1.0	-1.4	-0.9	-0.7
Hypothyroidism (self reported)	0.4	0.9	2.4	0.1	1.0	0.6	0.4	-1.1	1.5
Vitamin and mineral supplements	0.4	0.5	1.2	-0.4	0.9	0.6	0.6	1.1	0.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.8	-0.4	-0.3	-0.2	0.3	1.4	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.8	-2.0	0.7	1.1	0.7	-0.8	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	0.7	0.8	0.6	1.0	-0.8	0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	-0.2	1.0	1.1	0.6	0.2	0.6
Blood clot in the leg (DVT)	0.4	0.5	1.3	-0.0	0.3	1.1	0.3	-1.0	0.5
Gout (self-reported)	0.4	0.6	1.3	0.3	0.0	-1.0	-1.0	0.1	-1.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.5	-1.6	0.4	0.3	-0.3	-0.4	-0.1
Forced vital capacity (FVC), Best measure	0.4	1.3	3.6	-1.9	0.7	1.0	0.8	-1.2	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.2	0.5	-0.4	-0.8	-1.0	-1.1	0.1
Medication: Ibuprofen	0.4	0.5	1.2	-0.7	0.1	1.1	0.6	0.9	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	-0.1	0.8	1.2	0.9	0.3	-0.4
Osteoarthritis (self-reported)	0.4	0.6	2.0	0.6	-0.2	0.7	0.6	1.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.4	0.0	-1.0	-1.2	-1.1	-1.1	-0.1
Illnesses of father: High blood pressure	0.4	0.5	1.2	-0.3	0.9	0.8	0.2	1.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.2	0.2	0.4	1.1	0.3	-1.1	0.8
Alzheimer’s Disease (including proxy)	0.3	0.5	1.5	-0.3	0.4	0.7	0.6	1.2	0.0
Fasting Glucose	0.3	0.3	0.8	0.9	-0.4	-0.8	-0.0	0.0	-0.5
Lung FEV1/FVC ratio	0.3	1.4	2.8	1.3	-0.0	1.7	1.3	1.6	-0.0
Hair Pigment	0.3	7.5	12.5	0.4	-3.5	-3.4	-3.5	-1.8	-2.4
Pack years adult smoking proportion	0.3	0.5	1.1	-1.0	0.6	0.4	0.2	1.0	-0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.7	-0.5	-0.2	0.1	0.2	0.3	-1.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	0.8	-0.4	-0.2	0.0	0.4	-0.8
Multivitamins +/- minerals	0.3	0.4	1.9	0.1	-0.0	-0.4	-0.3	-1.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	-0.4	0.9	0.2	-0.2	-0.8	0.9
Fluid intelligence score	0.3	0.7	2.1	-0.5	0.9	0.4	0.4	-0.8	1.5
Impedance of arm (right)	0.3	1.3	5.1	1.2	-0.0	-0.7	0.0	-2.3	1.0
Impedance of arm (left)	0.3	1.6	7.0	0.8	-0.5	-1.1	-0.1	-2.6	0.6
Birth weight of first child	0.3	0.5	1.8	-0.5	-0.2	0.7	1.4	0.8	-0.2
Number of children fathered	0.3	0.3	0.9	-1.0	0.6	0.3	-0.4	0.6	0.4
Alcohol intake frequency.	0.3	0.6	1.2	0.4	-0.8	-0.9	-1.0	-0.1	-1.1
Leg pain on walking	0.3	0.3	1.0	0.3	0.2	0.6	1.0	0.3	0.6
Medication: Aspirin	0.3	0.4	1.0	0.9	0.1	0.4	-0.0	1.0	-0.7
Ever had bowel cancer screening	0.3	0.4	1.0	-0.7	-0.5	0.3	0.3	1.0	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	2.4	0.0	-0.1	0.1	-0.3	-1.6	-0.0
Miserableness	0.3	0.5	0.9	0.8	0.8	0.9	0.2	0.8	0.0
Wears glasses or contact lenses	0.3	0.4	1.0	0.4	0.5	0.2	0.7	-1.0	0.4
Mother’s age at death	0.3	0.3	0.9	-1.0	-0.4	-0.4	-0.3	0.5	-0.6
Ever depressed for a whole week	0.3	0.4	1.1	-0.7	-0.6	-0.5	-0.1	0.0	-1.1
Commuting to job workplace: Cycle	0.3	0.4	2.1	-1.5	0.0	0.3	0.1	-0.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	0.6	-0.6	-0.4	-0.4	-0.5	-1.1
Pack years of smoking	0.3	0.5	1.0	-0.7	0.8	0.6	0.4	1.0	-0.7
Depression (Nagel 2018)	0.2	0.3	0.7	-0.3	-0.2	-0.6	-0.9	0.3	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.1	-0.6	0.9	0.5	0.3	-1.1	0.7
LDL Cholesterol	0.2	0.3	1.2	-0.7	-0.4	-0.2	-1.1	-0.2	-0.3
Waist Hip Ratio (WHR)	0.2	1.0	2.7	-1.0	-1.1	0.9	1.6	0.3	0.4
Tanning	0.2	2.7	7.8	-0.7	-2.1	-1.1	-1.3	0.6	-2.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.1	0.1	1.1	0.5	-0.0	0.4	0.4
Relative age of first facial hair	0.2	0.4	1.9	0.1	-0.2	-0.2	-0.5	1.4	-0.4
Townsend deprivation index at recruitment	0.2	0.4	1.1	-0.1	-0.6	0.4	1.1	-0.4	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.8	-0.5	-0.0	-0.5	-0.9	-0.0	-0.2
Alcohol usually taken with meals	0.2	0.4	1.1	-0.5	0.5	-0.0	-0.1	-0.8	1.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.8	-0.9	-0.5	-0.1	0.4	0.4	-0.2
Heart attack	0.2	0.3	0.7	0.6	-0.3	-0.2	-0.2	-0.5	-0.9
Happiness	0.2	0.2	0.9	1.0	0.3	-0.0	-0.4	0.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.7	0.1	0.7	-0.0	0.1	-0.6	0.8
Pulse rate, automated reading	0.2	0.7	1.9	0.9	-0.1	-0.8	-0.3	-1.4	0.8
Family relationship satisfaction	0.2	0.2	0.9	1.0	-0.2	-0.0	-0.1	-0.4	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.9	0.3	-0.7	-0.1	0.2	0.9	-0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.3	-0.7	0.1	0.7	-0.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.4	0.6	0.3	0.8	0.3	0.1
Medication for cholesterol	0.2	0.3	0.7	-0.5	-0.4	-0.4	0.7	0.8	0.0
Medication: Gliclazide	0.2	0.2	0.4	-0.3	0.6	0.3	0.2	-0.6	0.4
Guilty feelings	0.2	0.2	0.8	0.1	-0.5	-0.4	-0.5	0.9	-0.1
Medication: Blood pressure	0.2	0.5	1.0	0.9	1.0	0.6	0.0	-0.5	0.6
Medication: Paracetamol	0.2	0.3	1.1	0.4	0.6	0.5	0.0	0.0	1.0
Alcohol drinker status: Never	0.2	0.3	1.1	0.5	-0.0	0.3	0.5	1.0	0.3
Average weekly beer plus cider intake	0.2	0.3	1.0	-0.2	-0.1	0.1	-0.1	0.7	-1.0
Supplements: Calcium	0.2	0.2	0.5	0.7	-0.7	0.1	-0.7	0.3	0.1
Heart disease (siblings)	0.2	0.2	0.5	0.4	0.4	0.6	0.7	-0.2	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.3	1.1	-1.1	-0.8	-0.1	-0.1	-0.3	0.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.5	-0.0	-0.4	0.0	0.5	-0.2
Breast Cancer	0.1	0.2	1.1	-0.0	-0.4	0.0	0.2	1.1	-0.2
Blood Eosinophil Count	0.1	0.7	2.8	-0.1	-1.7	-0.8	-0.6	0.8	-0.2
Blood Platelet Count	0.1	1.7	2.4	-1.6	1.2	1.4	1.3	-1.4	0.8
Allergy or Eczema	0.1	0.3	1.0	1.0	0.5	0.4	0.4	0.5	0.5
Chronotype (morning person)	0.1	0.3	1.1	0.2	-0.5	-0.2	-0.3	0.1	-1.1
Average weekly spirits intake	0.1	0.1	0.4	0.4	0.2	0.4	-0.1	0.6	-0.3
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.4	-0.1	-0.0	-0.2	-0.6	0.3
Had other major operations	0.1	0.1	0.2	0.5	0.0	-0.3	0.1	-0.2	0.2
Depression (self-reported)	0.1	0.1	0.2	0.3	0.2	0.5	-0.4	-0.0	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.1	0.5	0.4	0.0	0.2	0.7
Emphysema/chronic bronchitis	0.1	0.1	0.5	0.3	-0.3	-0.0	0.0	0.0	-0.7
Illnesses of father: Heart disease	0.1	0.2	0.8	-0.2	0.2	0.1	0.3	0.9	0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	-0.6	0.2	0.1	0.7	0.0	-0.1
Number of operations (self-reported)	0.1	0.2	0.5	0.2	0.4	-0.2	0.7	-0.5	0.5
Risk taking	0.1	0.2	0.4	-0.4	0.3	0.6	0.6	-0.2	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.2
Maternal smoking around birth	0.0	0.0	0.2	-0.4	-0.2	-0.2	0.0	-0.0	-0.1
Age when periods started (menarche)	0.0	0.1	0.2	-0.3	-0.4	0.1	0.1	-0.4	0.0
Unable to work because of sickness or disability	0.0	0.0	0.1	0.1	-0.4	-0.0	0.1	0.1	-0.2

Hub : Genes

CYTH1

Models

Trait associations