Best TWAS P=2.07e-45 · Best GWAS P=1.54e-53 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SIRT6 | 0.08 | 0.07 | lasso | 1 | 0.07 | 9.8e-09 | -6.02 | -6.0 | 1.7e-09 | 0.09 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | ANKRD24 | 0.13 | 0.08 | lasso | 4 | 0.08 | 5.4e-07 | -5.88 | -5.7 | 1.1e-08 | 0.08 | 0.88 | 0.02 | FALSE |
3 | GTEx | Adipose Subcutaneous | AMH | 0.18 | 0.05 | lasso | 8 | 0.06 | 1.9e-05 | -4.01 | 6.4 | 1.5e-10 | -0.22 | 0.93 | 0.00 | FALSE |
4 | GTEx | Adipose Subcutaneous | NFIC | 0.14 | 0.00 | enet | 11 | 0.00 | 2.7e-01 | -0.36 | -6.9 | 7.0e-12 | 0.01 | 0.02 | 0.71 | FALSE |
5 | GTEx | Adipose Visceral Omentum | NFIC | 0.20 | 0.00 | lasso | 5 | 0.02 | 2.2e-02 | 9.16 | -9.7 | 5.0e-22 | 0.07 | 0.07 | 0.14 | TRUE |
6 | GTEx | Artery Aorta | SIRT6 | 0.20 | 0.12 | lasso | 4 | 0.12 | 5.2e-07 | -5.88 | -5.8 | 8.0e-09 | 0.11 | 0.63 | 0.09 | FALSE |
7 | GTEx | Artery Tibial | DOT1L | 0.09 | 0.06 | lasso | 5 | 0.05 | 7.3e-05 | 13.45 | 12.2 | 5.0e-34 | -0.89 | 0.03 | 0.96 | FALSE |
8 | GTEx | Artery Tibial | NFIC | 0.14 | 0.13 | enet | 11 | 0.12 | 7.6e-10 | 9.16 | -9.1 | 6.4e-20 | 0.02 | 0.76 | 0.24 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | ANKRD24 | 0.64 | 0.16 | lasso | 6 | 0.14 | 1.9e-04 | -5.98 | -6.2 | 4.5e-10 | 0.11 | 0.28 | 0.04 | TRUE |
10 | GTEx | Breast Mammary Tissue (Male) | CTB-50L17.5 | 0.26 | -0.01 | enet | 23 | 0.03 | 7.9e-02 | 3.94 | -6.6 | 4.9e-11 | -0.02 | 0.04 | 0.32 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | ANKRD24 | 0.14 | 0.07 | enet | 30 | 0.09 | 1.8e-07 | -6.02 | -5.5 | 4.0e-08 | 0.09 | 0.90 | 0.01 | FALSE |
12 | GTEx | Colon Sigmoid | MAP2K2 | 0.20 | 0.11 | lasso | 3 | 0.13 | 3.0e-05 | 7.04 | 7.7 | 2.1e-14 | 0.00 | 0.01 | 0.92 | FALSE |
13 | GTEx | Colon Transverse | PTPRS | 0.17 | -0.01 | enet | 21 | 0.03 | 1.9e-02 | 4.30 | -8.2 | 2.4e-16 | -0.01 | 0.05 | 0.31 | TRUE |
14 | GTEx | Esophagus Mucosa | C19orf25 | 0.13 | 0.00 | enet | 19 | 0.00 | 6.9e-01 | 3.35 | -5.7 | 1.2e-08 | 0.00 | 0.00 | 0.01 | TRUE |
15 | GTEx | Esophagus Mucosa | CTB-50L17.5 | 0.20 | 0.04 | enet | 26 | 0.07 | 2.5e-05 | 6.87 | 7.2 | 8.4e-13 | -0.01 | 0.51 | 0.08 | TRUE |
16 | GTEx | Esophagus Muscularis | SIRT6 | 0.14 | 0.07 | lasso | 6 | 0.04 | 1.4e-03 | -5.88 | -5.8 | 6.8e-09 | 0.09 | 0.16 | 0.03 | FALSE |
17 | GTEx | Esophagus Muscularis | DOT1L | 0.12 | 0.03 | lasso | 5 | 0.05 | 6.3e-04 | 13.45 | 8.3 | 9.1e-17 | -0.82 | 0.01 | 0.97 | TRUE |
18 | GTEx | Esophagus Muscularis | NFIC | 0.21 | 0.03 | enet | 35 | 0.07 | 4.9e-05 | 4.82 | -7.0 | 1.8e-12 | 0.02 | 0.07 | 0.37 | FALSE |
19 | GTEx | Lung | ANKRD24 | 0.16 | 0.13 | enet | 12 | 0.12 | 8.3e-10 | -5.93 | -5.7 | 1.4e-08 | 0.10 | 1.00 | 0.00 | FALSE |
20 | GTEx | Muscle Skeletal | ANKRD24 | 0.13 | 0.08 | enet | 9 | 0.07 | 8.1e-08 | -5.88 | -5.8 | 7.0e-09 | 0.10 | 1.00 | 0.00 | FALSE |
21 | GTEx | Nerve Tibial | IZUMO4 | 0.23 | 0.07 | lasso | 6 | 0.14 | 1.9e-10 | -3.98 | -9.2 | 5.4e-20 | 0.70 | 0.03 | 0.97 | FALSE |
22 | GTEx | Nerve Tibial | MFSD12 | 0.17 | 0.02 | lasso | 4 | 0.03 | 1.8e-03 | 3.11 | -5.4 | 7.2e-08 | -0.04 | 0.10 | 0.60 | FALSE |
23 | GTEx | Prostate | UBXN6 | 0.27 | 0.15 | enet | 19 | 0.14 | 2.4e-04 | 3.81 | -6.3 | 3.0e-10 | -0.04 | 0.12 | 0.05 | TRUE |
24 | GTEx | Skin Sun Exposed Lower leg | AC004490.1 | 0.09 | 0.07 | enet | 11 | 0.10 | 2.3e-08 | -6.26 | 5.5 | 3.5e-08 | -0.52 | 0.82 | 0.12 | FALSE |
25 | GTEx | Testis | ANKRD24 | 0.44 | 0.18 | lasso | 7 | 0.19 | 5.0e-09 | -5.93 | -5.6 | 2.1e-08 | 0.10 | 0.99 | 0.00 | FALSE |
26 | GTEx | Thyroid | SIRT6 | 0.24 | 0.20 | lasso | 5 | 0.21 | 3.9e-16 | -5.93 | -5.8 | 6.4e-09 | 0.10 | 1.00 | 0.00 | FALSE |
27 | NTR | Blood | ARRDC5 | 0.04 | 0.00 | lasso | 6 | 0.01 | 4.3e-04 | 10.21 | 5.7 | 1.5e-08 | -0.07 | 0.65 | 0.01 | FALSE |
28 | NTR | Blood | C19orf35 | 0.03 | 0.01 | enet | 9 | 0.02 | 3.7e-07 | -2.90 | -6.5 | 9.9e-11 | 0.38 | 0.96 | 0.02 | TRUE |
29 | NTR | Blood | TMPRSS9 | 0.04 | 0.02 | lasso | 4 | 0.04 | 1.3e-11 | -1.43 | -6.4 | 1.6e-10 | 0.33 | 0.99 | 0.01 | FALSE |
30 | ROSMAP | Brain Pre-frontal Cortex | SIRT6 | 0.24 | 0.23 | lasso | 7 | 0.23 | 1.2e-29 | -5.93 | -6.0 | 2.6e-09 | 0.09 | 1.00 | 0.00 | FALSE |
31 | ROSMAP | Brain Pre-frontal Cortex | PIAS4 | 0.14 | 0.12 | lasso | 6 | 0.11 | 1.6e-13 | 6.06 | 6.5 | 9.1e-11 | 0.00 | 1.00 | 0.00 | FALSE |
32 | YFS | Blood | ANKRD24 | 0.04 | 0.01 | lasso | 6 | 0.01 | 6.0e-05 | -5.95 | -6.1 | 8.3e-10 | 0.09 | 0.94 | 0.00 | FALSE |
33 | YFS | Blood | ARRDC5 | 0.29 | 0.19 | enet | 62 | 0.24 | 3.8e-78 | 10.34 | 6.2 | 4.2e-10 | -0.09 | 1.00 | 0.00 | FALSE |
34 | YFS | Blood | MAP2K2 | 0.02 | 0.00 | blup | 373 | 0.01 | 5.9e-03 | -4.74 | -6.7 | 2.5e-11 | -0.02 | 0.01 | 0.95 | TRUE |
35 | YFS | Blood | PIAS4 | 0.06 | 0.02 | bslmm | 369 | 0.04 | 4.8e-14 | 6.06 | 7.8 | 9.5e-15 | 0.05 | 0.57 | 0.43 | TRUE |
36 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | AP3D1 | 0.05 | 0.00 | blup | 49 | 0.02 | 1.7e-02 | -3.26 | 6.6 | 4.1e-11 | -0.31 | 0.03 | 0.07 | TRUE |
37 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3D1 | 0.01 | 0.01 | blup | 52 | 0.01 | 5.4e-03 | -3.26 | 9.5 | 2.3e-21 | -0.54 | 0.05 | 0.11 | FALSE |
38 | The Cancer Genome Atlas | Breast Invasive Carcinoma | JSRP1 | 0.03 | 0.01 | blup | 33 | 0.01 | 2.0e-02 | -2.90 | -5.2 | 1.7e-07 | 0.11 | 0.04 | 0.09 | TRUE |
39 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AMH | 0.04 | 0.03 | blup | 35 | 0.02 | 1.3e-03 | -4.01 | 5.9 | 4.4e-09 | -0.21 | 0.29 | 0.11 | TRUE |
40 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOT1L | 0.08 | 0.12 | enet | 8 | 0.10 | 2.5e-11 | 13.45 | 14.1 | 2.1e-45 | -0.96 | 0.02 | 0.98 | TRUE |
41 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FZR1 | 0.21 | 0.07 | lasso | 3 | 0.07 | 5.6e-05 | -6.58 | -7.5 | 7.0e-14 | 0.07 | 0.00 | 0.97 | FALSE |
42 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | JSRP1 | 0.07 | 0.04 | blup | 33 | 0.03 | 7.8e-03 | -3.98 | 7.1 | 1.0e-12 | -0.43 | 0.01 | 0.11 | FALSE |
43 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C19orf77 | 0.16 | 0.12 | lasso | 3 | 0.14 | 3.6e-07 | 2.90 | 5.8 | 4.8e-09 | -0.04 | 0.36 | 0.55 | FALSE |
44 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DOT1L | 0.09 | 0.08 | blup | 60 | 0.07 | 4.1e-04 | -10.55 | 11.5 | 1.3e-30 | -0.87 | 0.02 | 0.95 | FALSE |
45 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | JSRP1 | 0.03 | 0.00 | blup | 33 | 0.02 | 2.1e-03 | -3.02 | -7.8 | 8.4e-15 | 0.18 | 0.01 | 0.26 | FALSE |
46 | The Cancer Genome Atlas | Rectum Adenocarcinoma | CREB3L3 | 0.34 | 0.12 | lasso | 4 | 0.13 | 5.6e-04 | -5.88 | -6.2 | 7.5e-10 | 0.08 | 0.07 | 0.09 | FALSE |
47 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DOT1L | 0.40 | -0.01 | enet | 20 | 0.03 | 3.6e-02 | -4.60 | 9.0 | 2.5e-19 | -0.44 | 0.01 | 0.21 | TRUE |
48 | The Cancer Genome Atlas | Thyroid Carcinoma | KDM4B | 0.05 | 0.05 | lasso | 2 | 0.04 | 4.7e-05 | 7.08 | 5.3 | 1.4e-07 | -0.03 | 0.47 | 0.04 | FALSE |