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chr19:788,074-6,033,976

Best TWAS P=2.07e-45 · Best GWAS P=1.54e-53 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOT1L	0.08	0.12	enet	8	0.10	2.5e-11	13.45	14.1	2.1e-45	-0.96	0.02	0.98	TRUE
5	GTEx	Adipose Visceral Omentum	NFIC	0.20	0.00	lasso	5	0.02	2.2e-02	9.16	-9.7	5.0e-22	0.07	0.07	0.14	TRUE
47	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DOT1L	0.40	-0.01	enet	20	0.03	3.6e-02	-4.60	9.0	2.5e-19	-0.44	0.01	0.21	TRUE
17	GTEx	Esophagus Muscularis	DOT1L	0.12	0.03	lasso	5	0.05	6.3e-04	13.45	8.3	9.1e-17	-0.82	0.01	0.97	TRUE
13	GTEx	Colon Transverse	PTPRS	0.17	-0.01	enet	21	0.03	1.9e-02	4.30	-8.2	2.4e-16	-0.01	0.05	0.31	TRUE
35	YFS	Blood	PIAS4	0.06	0.02	bslmm	369	0.04	4.8e-14	6.06	7.8	9.5e-15	0.05	0.57	0.43	TRUE
15	GTEx	Esophagus Mucosa	CTB-50L17.5	0.20	0.04	enet	26	0.07	2.5e-05	6.87	7.2	8.4e-13	-0.01	0.51	0.08	TRUE
34	YFS	Blood	MAP2K2	0.02	0.00	blup	373	0.01	5.9e-03	-4.74	-6.7	2.5e-11	-0.02	0.01	0.95	TRUE
36	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AP3D1	0.05	0.00	blup	49	0.02	1.7e-02	-3.26	6.6	4.1e-11	-0.31	0.03	0.07	TRUE
28	NTR	Blood	C19orf35	0.03	0.01	enet	9	0.02	3.7e-07	-2.90	-6.5	9.9e-11	0.38	0.96	0.02	TRUE
23	GTEx	Prostate	UBXN6	0.27	0.15	enet	19	0.14	2.4e-04	3.81	-6.3	3.0e-10	-0.04	0.12	0.05	TRUE
9	GTEx	Brain Cerebellar Hemisphere	ANKRD24	0.64	0.16	lasso	6	0.14	1.9e-04	-5.98	-6.2	4.5e-10	0.11	0.28	0.04	TRUE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AMH	0.04	0.03	blup	35	0.02	1.3e-03	-4.01	5.9	4.4e-09	-0.21	0.29	0.11	TRUE
14	GTEx	Esophagus Mucosa	C19orf25	0.13	0.00	enet	19	0.00	6.9e-01	3.35	-5.7	1.2e-08	0.00	0.00	0.01	TRUE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	JSRP1	0.03	0.01	blup	33	0.01	2.0e-02	-2.90	-5.2	1.7e-07	0.11	0.04	0.09	TRUE
7	GTEx	Artery Tibial	DOT1L	0.09	0.06	lasso	5	0.05	7.3e-05	13.45	12.2	5.0e-34	-0.89	0.03	0.96	FALSE
44	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DOT1L	0.09	0.08	blup	60	0.07	4.1e-04	-10.55	11.5	1.3e-30	-0.87	0.02	0.95	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3D1	0.01	0.01	blup	52	0.01	5.4e-03	-3.26	9.5	2.3e-21	-0.54	0.05	0.11	FALSE
21	GTEx	Nerve Tibial	IZUMO4	0.23	0.07	lasso	6	0.14	1.9e-10	-3.98	-9.2	5.4e-20	0.70	0.03	0.97	FALSE
8	GTEx	Artery Tibial	NFIC	0.14	0.13	enet	11	0.12	7.6e-10	9.16	-9.1	6.4e-20	0.02	0.76	0.24	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	JSRP1	0.03	0.00	blup	33	0.02	2.1e-03	-3.02	-7.8	8.4e-15	0.18	0.01	0.26	FALSE
12	GTEx	Colon Sigmoid	MAP2K2	0.20	0.11	lasso	3	0.13	3.0e-05	7.04	7.7	2.1e-14	0.00	0.01	0.92	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FZR1	0.21	0.07	lasso	3	0.07	5.6e-05	-6.58	-7.5	7.0e-14	0.07	0.00	0.97	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JSRP1	0.07	0.04	blup	33	0.03	7.8e-03	-3.98	7.1	1.0e-12	-0.43	0.01	0.11	FALSE
18	GTEx	Esophagus Muscularis	NFIC	0.21	0.03	enet	35	0.07	4.9e-05	4.82	-7.0	1.8e-12	0.02	0.07	0.37	FALSE
4	GTEx	Adipose Subcutaneous	NFIC	0.14	0.00	enet	11	0.00	2.7e-01	-0.36	-6.9	7.0e-12	0.01	0.02	0.71	FALSE
10	GTEx	Breast Mammary Tissue (Male)	CTB-50L17.5	0.26	-0.01	enet	23	0.03	7.9e-02	3.94	-6.6	4.9e-11	-0.02	0.04	0.32	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	PIAS4	0.14	0.12	lasso	6	0.11	1.6e-13	6.06	6.5	9.1e-11	0.00	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	AMH	0.18	0.05	lasso	8	0.06	1.9e-05	-4.01	6.4	1.5e-10	-0.22	0.93	0.00	FALSE
29	NTR	Blood	TMPRSS9	0.04	0.02	lasso	4	0.04	1.3e-11	-1.43	-6.4	1.6e-10	0.33	0.99	0.01	FALSE
33	YFS	Blood	ARRDC5	0.29	0.19	enet	62	0.24	3.8e-78	10.34	6.2	4.2e-10	-0.09	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Rectum Adenocarcinoma	CREB3L3	0.34	0.12	lasso	4	0.13	5.6e-04	-5.88	-6.2	7.5e-10	0.08	0.07	0.09	FALSE
32	YFS	Blood	ANKRD24	0.04	0.01	lasso	6	0.01	6.0e-05	-5.95	-6.1	8.3e-10	0.09	0.94	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SIRT6	0.08	0.07	lasso	1	0.07	9.8e-09	-6.02	-6.0	1.7e-09	0.09	1.00	0.00	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	SIRT6	0.24	0.23	lasso	7	0.23	1.2e-29	-5.93	-6.0	2.6e-09	0.09	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C19orf77	0.16	0.12	lasso	3	0.14	3.6e-07	2.90	5.8	4.8e-09	-0.04	0.36	0.55	FALSE
26	GTEx	Thyroid	SIRT6	0.24	0.20	lasso	5	0.21	3.9e-16	-5.93	-5.8	6.4e-09	0.10	1.00	0.00	FALSE
16	GTEx	Esophagus Muscularis	SIRT6	0.14	0.07	lasso	6	0.04	1.4e-03	-5.88	-5.8	6.8e-09	0.09	0.16	0.03	FALSE
20	GTEx	Muscle Skeletal	ANKRD24	0.13	0.08	enet	9	0.07	8.1e-08	-5.88	-5.8	7.0e-09	0.10	1.00	0.00	FALSE
6	GTEx	Artery Aorta	SIRT6	0.20	0.12	lasso	4	0.12	5.2e-07	-5.88	-5.8	8.0e-09	0.11	0.63	0.09	FALSE
2	GTEx	Adipose Subcutaneous	ANKRD24	0.13	0.08	lasso	4	0.08	5.4e-07	-5.88	-5.7	1.1e-08	0.08	0.88	0.02	FALSE
19	GTEx	Lung	ANKRD24	0.16	0.13	enet	12	0.12	8.3e-10	-5.93	-5.7	1.4e-08	0.10	1.00	0.00	FALSE
27	NTR	Blood	ARRDC5	0.04	0.00	lasso	6	0.01	4.3e-04	10.21	5.7	1.5e-08	-0.07	0.65	0.01	FALSE
25	GTEx	Testis	ANKRD24	0.44	0.18	lasso	7	0.19	5.0e-09	-5.93	-5.6	2.1e-08	0.10	0.99	0.00	FALSE
24	GTEx	Skin Sun Exposed Lower leg	AC004490.1	0.09	0.07	enet	11	0.10	2.3e-08	-6.26	5.5	3.5e-08	-0.52	0.82	0.12	FALSE
11	GTEx	Cells Transformed fibroblasts	ANKRD24	0.14	0.07	enet	30	0.09	1.8e-07	-6.02	-5.5	4.0e-08	0.09	0.90	0.01	FALSE
22	GTEx	Nerve Tibial	MFSD12	0.17	0.02	lasso	4	0.03	1.8e-03	3.11	-5.4	7.2e-08	-0.04	0.10	0.60	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	KDM4B	0.05	0.05	lasso	2	0.04	4.7e-05	7.08	5.3	1.4e-07	-0.03	0.47	0.04	FALSE