Hub : Genes

PTPRS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.175	0.0680	7.3e-03	-0.006	NA	0.027	NA	0.001	9.5e-01	NA	1.9e-02	NA	3.0e-01
2	GTEx	Thyroid	0.156	0.0420	3.1e-04	0.113	NA	0.069	NA	0.116	6.1e-09	NA	5.5e-06	NA	3.6e-09
3	ROSMAP	Brain Pre-frontal Cortex	0.125	0.0294	1.4e-06	0.098	0.067	0.084	0.089	0.098	1.6e-12	5.4e-09	6.6e-11	1.8e-11	1.3e-12
4	TCGA	Glioblastoma Multiforme	0.400	0.1100	1.3e-04	-0.005	0.178	0.036	NA	0.014	4.8e-01	4.4e-06	2.9e-02	NA	1.2e-01
5	TCGA	Thyroid Carcinoma	0.085	0.0310	3.4e-04	-0.003	0.035	0.002	NA	-0.001	9.1e-01	2.2e-04	2.1e-01	NA	4.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.8	2.4	-1.5	0.9	-0.6	0.6	0.5
Bipolar Disorder or Schizophrenia	0.3	0.8	2.2	0.7	0.4	-1.5	-0.6	-0.7
Depressed Affect (Nagel 2018)	0.7	1.5	2.2	-0.9	1.5	1.3	-1.4	1.0
Depression (Nagel 2018)	1.5	2.3	3.9	0.4	1.4	-1.6	-2.0	1.6
Intelligence (Savage-Jansen 2018)	0.9	2.9	8.1	-2.8	0.9	1.9	1.3	0.4
Neuroticism (Nagel 2018)	0.3	0.7	2.2	-0.9	0.6	1.5	-0.0	-0.4
Schizophrenia (2018)	0.8	1.6	5.1	2.2	-0.2	-1.4	-0.6	-0.8
Schizophrenia vs Biploar Disorder	1.6	2.1	3.2	1.8	0.0	-1.7	1.1	-1.8
Worry (Nagel 2018)	0.5	1.1	3.3	-0.2	-0.2	1.8	1.3	-0.3
Alzheimer’s Disease (in mother)	1.1	1.3	2.7	0.5	0.0	1.6	-1.5	1.3
Alzheimer’s Disease (in father)	0.9	1.0	2.1	-1.3	0.4	-1.4	0.8	0.6
Alzheimer’s Disease (including proxy)	0.4	0.5	2.3	-0.2	-0.0	0.6	-0.1	1.5
Crohns Disease (2017)	0.2	0.4	1.6	0.2	0.0	-0.3	0.4	-1.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	0.6	0.7	0.6	0.1	0.4
Ulcerative Colitis (UC)	0.5	0.9	1.5	1.2	1.0	0.7	-0.4	1.2
Major Depression (MDD)	1.2	1.4	2.8	-1.7	-0.4	1.1	-0.7	1.6
Reaction Time	0.9	1.6	4.2	-2.0	-0.1	0.1	0.7	-1.9
Verbal and Numeric Reasoning (VNR)	0.5	1.3	5.1	-2.3	1.0	0.7	0.2	0.1
Breast Cancer	0.4	0.9	2.0	0.7	0.7	-0.8	-1.1	-1.4
Ovarian Cancer	1.2	1.6	2.6	-0.8	1.2	1.6	-1.6	1.0
Prostate Cancer	1.2	1.7	2.5	-0.8	-1.3	-1.2	1.6	-1.6
Age at First Birth	0.4	0.6	1.5	0.6	-1.2	-0.7	0.9	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	3.1	-0.1	0.1	1.0	-1.8	0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.2	0.5	0.7	-0.4	-0.2	0.2	0.3
Mean Putamen Volume	0.3	0.3	0.8	0.1	0.6	0.5	-0.9	0.2
Fasting Glucose	1.6	1.9	5.9	2.4	0.8	1.3	0.0	1.2
HbA1C	0.4	0.5	0.7	0.8	0.5	0.8	-0.8	0.4
HDL Cholesterol	0.2	0.3	0.9	0.2	-0.5	1.0	0.4	-0.2
LDL Cholesterol	0.4	0.6	1.8	-0.4	0.4	-0.1	-1.4	1.0
Lupus	0.4	0.6	1.7	-0.0	-0.1	1.3	-0.8	0.8
Neuroticism (2016)	0.4	0.6	2.6	0.2	-0.1	0.5	0.5	-1.6
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.1	-0.6	-0.6	0.2	-0.4
Rheumatoid Arthritis	0.2	0.3	0.6	0.7	0.8	-0.4	0.5	0.0
Schizophrenia (2014)	0.9	1.9	5.5	1.2	0.6	-2.4	0.2	-1.5
Triglycerides	0.1	0.2	0.6	0.1	0.6	0.1	0.8	-0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.7	0.2	0.7	-0.7	0.7	-0.8
Ulcerative Colitis	1.1	1.6	4.6	1.0	1.4	0.7	0.1	2.1
Blood Eosinophil Count	0.5	3.5	7.2	1.4	0.9	-2.7	2.3	-1.5
Blood Platelet Count	0.2	2.5	6.6	2.6	1.7	-0.6	-1.4	0.9
Blood Red Count	0.0	0.4	1.3	-0.5	-0.5	0.3	0.7	-1.1
Blood White Count	0.5	3.8	6.9	2.5	-1.6	-1.4	2.6	-1.1
Heel T-Score	0.2	1.7	4.8	0.1	-2.2	-0.1	0.8	-1.8
BMI	0.9	5.0	12.0	2.4	3.5	0.4	-2.6	0.3
Height	1.3	25.6	100.0	-10.0	0.4	4.3	-0.8	3.0
Waist Hip Ratio (WHR)	1.2	5.2	10.5	0.6	1.7	-3.2	3.2	-1.5
Systolic Blood Pressure	1.1	5.3	12.5	3.5	1.8	0.6	-1.0	3.1
Smoking Status	0.3	0.7	1.7	1.3	-0.8	0.9	-0.2	0.7
Allergy or Eczema	0.1	0.4	1.4	0.1	0.2	-1.2	0.7	-0.4
Cardiovascular Disease	1.8	6.0	8.8	2.9	3.0	0.4	-2.6	2.4
Hypothyroidism (self reported)	0.9	2.1	8.1	2.8	0.9	-0.9	-1.0	-0.1
Respiratory disease	0.1	0.3	1.0	0.6	0.1	-0.2	-1.0	0.3
Type 2 Diabetes (T2D) (2018)	1.4	2.7	6.7	2.6	1.3	-2.2	0.0	-0.1
Lung FEV1/FVC ratio	0.3	1.3	2.4	1.3	-1.3	-0.1	-1.6	1.0
Lung FVC	0.9	4.5	10.1	-0.9	-3.2	2.7	2.1	0.4
Neuroticism	0.3	0.6	2.0	-0.8	-0.3	1.4	-0.4	-0.5
Chronotype (morning person)	1.0	2.2	5.7	-1.1	-0.3	2.1	2.4	0.0
Hair Pigment	0.1	1.8	5.5	-1.5	1.0	-0.3	2.4	0.3
Tanning	0.0	0.5	1.8	-0.2	1.4	0.0	0.1	0.7
Hand grip strength (left)	1.3	3.4	4.9	-1.4	1.5	1.9	-2.0	2.2
Number of treatments/medications taken	4.3	7.7	18.5	4.3	2.5	-0.3	-2.2	3.0
Average weekly spirits intake	1.1	1.4	3.4	-0.5	-0.2	-0.8	1.6	-1.8
Sensitivity / hurt feelings	0.9	1.6	2.2	-1.4	-0.7	-1.2	1.5	-1.3
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.4	1.9	0.7	-1.2	-1.5	1.1
Hearing difficulty/problems: Yes	1.7	2.7	7.1	2.7	-1.0	-1.8	-1.0	-0.9
Relative age of first facial hair	1.1	2.2	4.8	-2.2	1.1	0.8	2.0	-0.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.9	1.2	-0.1	-1.6	-1.7	-1.0
Ever used hormone-replacement therapy (HRT)	0.8	1.1	4.5	2.1	0.1	-0.6	-0.6	0.4
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	1.3	-1.0	-0.9	-0.6	-0.8
Systolic blood pressure, automated reading	1.4	4.1	10.4	3.2	1.4	0.3	-1.2	2.6
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	7.2	2.7	-0.5	0.0	-0.2	-0.1
Angina	1.4	1.9	7.9	2.8	0.3	0.5	-1.1	0.2
Medication for hormone replacement therapy	0.3	0.3	0.6	0.6	0.7	0.1	-0.5	0.8
Vitamin and mineral supplements	0.6	0.8	2.6	-0.2	0.6	1.6	0.6	0.6
Supplements: Zinc	2.2	2.4	6.2	-0.9	-0.4	-2.0	2.5	-1.0
Medication: Co-codamol	1.9	2.2	7.3	2.7	-0.1	-0.6	-1.5	-0.9
Medication: Metformin	2.4	3.4	7.7	2.8	2.5	1.4	0.3	1.0
Diabetes (father)	1.9	2.3	6.3	2.1	-0.4	-2.5	0.2	-0.8
Diabetes (mother)	0.5	0.6	1.4	1.2	0.2	-0.7	0.4	-0.9
Severe depression (siblings)	1.5	1.7	3.6	-0.5	1.9	0.6	-0.9	1.8
Pack years adult smoking proportion	0.3	0.4	1.3	-0.2	0.5	-0.6	-1.2	0.3
Impedance of leg (right)	0.8	4.0	11.0	-0.9	-1.9	-1.6	3.3	-1.5
Leg fat-free mass (left)	0.9	4.7	7.6	-2.4	1.8	2.7	-2.2	1.5
Trunk fat percentage	0.2	1.0	2.2	1.5	0.6	1.1	-0.7	-0.8
Hand grip strength (right)	1.6	4.4	9.7	-2.2	1.0	3.1	-1.7	1.9
Townsend deprivation index at recruitment	0.7	1.1	2.3	1.2	-1.2	-1.5	-0.3	0.0
Current tobacco smoking	0.3	0.5	1.2	-0.2	-1.1	1.1	0.3	0.1
Average weekly fortified wine intake	0.9	1.1	3.2	-0.3	1.8	-0.1	-1.3	0.6
Maternal smoking around birth	0.9	1.3	2.3	1.2	-1.2	-1.5	0.8	-0.7
Fed-up feelings	0.5	0.9	3.5	0.9	0.1	0.6	-0.1	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.2	1.2	0.3	-1.8	-0.1	0.8
Relative age voice broke	1.2	1.9	5.0	-2.2	1.0	0.7	1.7	-0.3
Taking other prescription medications	5.1	7.8	24.7	5.0	1.6	-0.8	-2.4	2.4
Age when periods started (menarche)	1.9	4.5	13.0	-3.6	-0.1	1.2	2.6	-1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.3	1.1	-1.0	-1.0	0.8	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.6	1.2	-0.3	0.6	-1.2	-0.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.3	1.1	-0.4	-1.0	-0.6	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.9	-0.8	-0.0	0.1	0.9	-0.2
Serious illness, injury or assault to yourself	1.3	1.6	5.9	2.4	1.3	-0.5	0.3	0.4
High blood pressure	1.9	5.3	9.3	1.7	3.1	1.2	-2.3	2.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.4	-0.6	-0.1	-1.2	1.2	-0.3
Multivitamins +/- minerals	1.4	1.8	4.3	-1.2	-0.9	-2.1	0.6	-1.5
Stomach or abdominal pain in last month	0.9	1.1	2.0	-0.8	1.0	-1.3	1.4	0.1
Supplements: Glucosamine	1.0	1.3	2.1	0.6	-1.4	-0.5	1.4	-1.3
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	7.8	-1.2	-2.5	-1.8	0.8	-2.8
Medication: Atenolol	0.2	0.3	0.5	0.6	0.7	0.6	-0.2	-0.4
Medication: Levothyroxine sodium	1.1	1.8	5.3	2.3	0.4	-1.2	-1.5	-0.2
Sitting height	1.8	12.5	41.6	-6.4	-1.4	4.1	0.2	1.4
Chronic bronchitis/emphysema (father)	1.4	1.7	3.1	1.7	1.2	-1.8	-1.0	0.2
High blood pressure (mother)	0.2	0.3	0.6	0.5	0.6	0.4	-0.7	0.3
Body mass index (BMI)	0.8	3.5	11.0	3.3	1.7	0.3	-1.8	0.1
Impedance of leg (left)	0.7	3.2	7.8	-1.0	-1.9	-1.2	2.8	-1.5
Leg predicted mass (left)	0.9	4.6	7.1	-2.5	1.8	2.7	-2.2	1.4
Trunk fat mass	0.2	1.1	2.2	0.5	1.0	1.5	-1.4	-0.0
Waist circumference	0.3	1.2	3.0	1.7	1.4	0.1	-1.1	-0.1
Number of incorrect matches in round	0.7	1.2	2.6	0.8	-0.9	-1.6	0.6	-1.1
Past tobacco smoking	0.9	1.7	3.1	-1.4	0.2	-1.8	1.6	-0.9
Alcohol usually taken with meals	1.6	2.6	4.6	-0.4	-1.5	-1.5	2.0	-2.1
Nervous feelings	0.3	0.5	2.0	0.1	0.5	1.4	0.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.2	1.0	-0.2	0.9	-1.5	1.8
Hearing difficulty/problems with background noise	1.6	2.6	5.2	1.3	-1.1	-2.3	-1.0	-2.0
Hair/balding pattern: Pattern 2	0.5	0.7	3.2	1.8	-0.1	0.4	-0.3	0.1
Had menopause	0.4	0.5	1.9	0.6	-0.2	-0.5	0.2	-1.4
Had other major operations	0.8	1.0	2.8	1.7	0.2	-0.6	1.2	-0.4
Forced vital capacity (FVC)	1.3	4.9	17.3	-4.2	-0.9	1.8	1.4	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.3	1.5	-1.0	-0.0	-1.4	-0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	-0.9	0.6	-1.0	-0.4	-0.7
Qualifications: None of the above	1.3	2.8	7.0	2.7	-0.6	-2.1	1.5	-0.2
Financial difficulties in last 2 years	1.6	2.1	6.2	1.8	-0.6	-2.5	0.3	-0.9
Mouth/teeth dental problems	0.3	0.4	0.8	0.1	-0.3	0.7	-0.9	0.8
Heart attack	1.6	2.0	7.2	2.7	-0.0	-1.3	0.3	-1.1
Allergy	0.2	0.4	1.5	0.1	-0.1	1.2	-0.3	0.4
Pain all over the body in last month	1.0	1.1	3.3	0.7	0.8	0.9	-0.2	1.8
Diabetes (self-reported)	1.8	2.8	8.8	3.0	2.2	-0.3	-0.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.1	0.6	0.3	1.1	0.2	-0.3
Medication: Ramipril	1.1	1.5	6.4	2.5	0.3	-0.8	-0.4	-0.1
Medication: Simvastatin	1.0	1.5	4.7	1.2	2.2	0.5	-0.8	0.7
Fluid intelligence score	1.1	2.2	8.0	-2.8	-0.7	0.3	0.4	-1.6
Illnesses of siblings	1.7	2.4	4.7	-1.9	-1.8	2.2	-0.1	-0.7
Neuroticism score	0.3	0.7	2.1	-1.5	-0.2	1.0	-0.0	-0.5
Weight	0.5	2.5	4.2	-0.6	1.7	1.9	-2.0	1.1
Impedance of arm (right)	0.1	0.7	2.2	-0.2	-0.5	-0.4	0.8	-1.5
Arm fat percentage (right)	1.0	3.9	14.1	3.8	1.3	-0.0	-1.7	-0.8
Trunk fat-free mass	1.1	6.2	14.0	-3.7	1.9	1.9	-1.9	2.5
Hip circumference	0.5	2.3	5.6	-0.2	0.8	2.1	-2.4	0.8
Time employed in main current job	0.2	0.2	0.5	-0.7	0.6	0.4	0.2	0.4
Alcohol intake versus 10 years previously	1.2	1.7	2.8	1.7	1.3	0.1	-1.5	1.4
Father’s age at death	2.1	2.9	7.5	-2.7	1.7	2.0	0.3	0.5
Worrier / anxious feelings	0.3	0.5	1.5	-0.7	-0.1	1.2	0.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.4	1.1	1.5	-0.5	-1.8	0.8
Falls in the last year	1.2	1.6	3.0	1.7	0.8	-0.2	-1.4	1.6
Hair/balding pattern: Pattern 3	0.3	0.5	1.3	0.2	0.2	1.1	0.3	-0.9
Number of live births	1.2	1.7	4.1	0.7	-0.7	-2.0	1.2	-1.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	6.9	-2.6	-1.1	1.4	1.2	1.0
Pulse rate	2.0	3.4	8.4	-2.9	1.1	1.3	1.1	2.1
Happiness	0.7	0.9	1.3	0.2	1.0	1.1	-1.1	1.0
Noisy workplace	1.2	1.5	6.7	2.6	-0.4	0.4	-0.2	0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.3	-1.8	0.1	-0.6	1.0	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.7	-1.3	-0.2	-0.0	0.2	0.6
Mouth/teeth dental problems: Dentures	0.8	1.4	4.1	2.0	1.3	0.9	-0.4	0.4
Asthma	0.2	0.5	1.2	-0.1	0.9	-1.1	-0.5	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.1	-1.4	1.1	-1.5	0.4	0.1
Medication: Cholesterol lowering	1.4	2.1	3.3	1.8	0.9	1.6	-1.6	1.2
Depression (self-reported)	1.5	1.8	3.1	1.8	-0.8	0.8	-1.6	1.4
Medication: Lansoprazole	1.0	1.2	3.9	0.8	-0.3	0.3	2.0	-1.1
Prospective memory result	0.5	0.6	1.3	-0.0	1.0	-0.0	0.9	1.1
Lung cancer (father)	0.6	0.7	1.8	0.4	-0.1	1.2	1.3	-0.1
Illnesses of mother	0.4	0.5	1.7	-0.6	-0.1	-1.3	0.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	7.6	-2.8	-1.1	1.5	0.9	1.2
Pulse wave Arterial Stiffness index	1.3	1.5	4.5	1.3	-2.1	-0.8	0.7	-0.5
Impedance of arm (left)	0.5	2.4	4.6	-1.3	-1.9	0.1	1.4	-2.1
Arm fat mass (right)	0.5	1.9	3.6	1.9	1.4	0.9	-1.7	-0.1
Trunk predicted mass	1.1	6.3	14.1	-3.8	2.0	1.9	-2.0	2.4
Standing height	1.8	17.5	67.2	-8.2	0.6	3.7	-1.1	2.3
Length of working week for main job	0.3	0.3	0.7	-0.5	-0.1	0.4	-0.7	-0.9
Exposure to tobacco smoke at home	0.5	0.6	1.3	-0.7	-0.9	-1.1	-0.6	0.1
Breastfed as a baby	1.4	1.7	4.8	-1.1	-0.8	-2.2	0.3	-1.3
Tense / ‘highly strung’	0.7	1.2	2.5	1.0	1.6	1.1	0.5	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	6.8	-0.4	1.1	2.5	-0.6	2.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.1	-0.6	-0.6	-0.1	-0.6
Birth weight of first child	0.6	1.0	2.3	-1.5	-0.3	1.4	-0.5	0.7
Peak expiratory flow (PEF)	0.4	1.0	2.3	0.5	-0.9	-0.2	-1.3	1.5
Pulse wave reflection index	2.5	3.1	7.0	2.4	-2.6	-0.4	-0.4	-1.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.2	-1.2	0.6	1.0	1.5	-0.2
Loud music exposure frequency	0.6	0.6	2.1	-1.5	-0.9	0.2	-0.4	-0.3
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	7.5	-2.7	0.5	-0.1	-0.7	-1.0
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	5.4	-1.4	-1.0	-1.6	2.3	-1.1
Blood clot in the leg (DVT)	1.4	1.8	5.9	0.2	1.3	0.8	-0.9	2.4
Medication: Paracetamol	1.7	2.8	11.6	0.6	0.1	-3.4	0.6	-1.3
Headache pain in last month	2.1	3.7	9.4	0.6	2.2	-3.1	1.5	-1.2
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	5.5	-1.1	-1.5	-2.3	1.3	-2.2
Glaucoma (self-reported)	0.5	0.6	2.0	-0.5	-0.3	-0.7	-1.4	0.6
Gout (self-reported)	0.9	1.2	4.2	-0.0	2.1	-0.3	-0.9	0.9
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	5.4	2.3	0.5	-1.8	-1.0	-1.3
Medication: Amlodipine	3.0	4.2	8.8	0.8	2.3	2.2	-1.1	3.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.7	-1.3	-0.0	-0.5	1.0	-0.3
Birth weight	2.3	5.1	14.8	-2.1	-0.2	3.9	-1.4	2.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.5	1.6	0.3	-0.6	-0.3	-0.5
High blood pressure (siblings)	1.4	2.0	4.3	2.1	2.1	-0.9	-0.4	0.8
Forced vital capacity (FVC), Best measure	1.6	6.0	19.4	-4.4	-0.7	2.6	1.2	1.4
Body fat percentage	0.4	1.5	5.1	2.3	0.4	0.5	-1.1	-0.9
Leg fat percentage (right)	0.7	2.5	10.2	3.2	0.1	-0.8	-0.8	-1.0
Arm fat-free mass (right)	0.9	4.7	12.1	-3.5	1.1	2.3	-1.4	1.7
Exposure to tobacco smoke outside home	2.0	2.7	5.3	0.9	2.3	1.2	-2.0	1.5
Comparative body size at age 10	0.4	1.0	1.7	1.3	-0.9	0.7	-1.2	-0.6
Number of full brothers	0.3	0.3	1.1	-0.4	1.0	-0.3	-0.5	0.3
Worry too long after embarrassment	0.3	0.6	0.8	-0.9	-0.7	0.7	-0.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.9	-1.0	-0.4	0.1	-1.4	0.7
Wheeze or whistling in the chest in last year	0.7	1.3	3.4	1.9	1.3	0.5	-1.1	0.1
Number of children fathered	1.0	1.1	3.2	-1.8	-0.2	-0.2	1.5	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.2	-0.6	-1.3	0.6	-1.5	0.8
Age at first live birth	0.9	1.6	7.2	-2.7	-0.2	0.5	0.5	-0.6
Pulse wave peak to peak time	1.6	1.9	4.3	-1.9	2.1	0.9	-0.6	0.6
Health satisfaction	1.9	2.5	6.9	2.6	1.5	-0.2	0.4	1.7
Shortness of breath walking on level ground	1.8	2.2	8.9	3.0	0.6	0.8	-0.1	0.9
Qualifications: College or University degree	0.8	2.6	8.6	-2.9	0.4	1.3	1.1	-1.2
Eye problems/disorders: None of the above	0.9	1.0	3.7	-0.9	0.6	1.9	-0.4	0.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.7	0.4	-0.4	-1.1	1.3	-0.3
Emphysema/chronic bronchitis	0.3	0.4	1.2	0.7	0.3	-0.1	-1.1	0.1
Medication for pain relief, constipation, heartburn	1.3	2.2	6.9	-0.4	-1.5	2.6	1.2	-0.4
Neck or shoulder pain in last month	0.9	1.3	3.1	0.3	0.9	-1.8	-1.2	-0.8
Medication: Blood pressure	1.9	3.4	7.2	0.1	1.4	2.4	-1.4	2.7
Angina (self-reported)	1.4	1.9	8.6	2.9	0.1	0.6	-0.7	0.1
Migraine (self-reported)	0.3	0.4	1.0	-1.0	-0.0	0.4	-0.1	0.9
Medication: Ibuprofen	0.6	0.7	1.4	-0.8	1.0	-1.2	0.4	0.6
Medication: Allopurinol	1.7	2.3	5.8	0.9	2.4	-0.8	-1.1	1.7
Medication: Omeprazole	1.4	1.6	4.3	1.6	-0.1	-0.8	-2.1	0.8
Medication: Seretide 50 evohaler	0.4	0.5	1.6	1.2	-0.5	0.6	-0.5	0.4
Mean time to correctly identify matches	0.5	0.9	2.7	-1.3	-0.4	0.3	0.2	-1.7
Heart disease (mother)	0.1	0.1	0.2	0.1	-0.0	-0.4	0.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.4	0.6	0.5	-1.4	0.5	-2.1
Whole body fat mass	0.4	1.5	2.9	1.1	1.2	1.4	-1.7	0.3
Leg fat mass (right)	0.3	1.2	2.6	1.6	0.9	0.6	-1.4	-0.2
Arm predicted mass (right)	1.1	5.5	14.3	-3.8	1.4	2.2	-1.7	1.9
Pulse rate, automated reading	0.3	1.0	3.5	-0.1	0.9	0.3	0.8	1.9
Alcohol intake frequency.	0.9	2.0	4.2	2.0	1.1	0.3	-1.7	1.3
Comparative height size at age 10	1.1	5.9	9.4	-3.1	1.1	2.5	-2.3	2.8
Number of full sisters	2.5	3.0	8.4	1.8	-1.2	-2.9	-0.3	-1.4
Suffer from ‘nerves’	0.7	1.1	2.4	0.2	-0.7	1.5	1.6	-0.6
Overall health rating	3.0	6.5	23.5	4.8	0.8	-1.4	-2.1	1.4
Chest pain or discomfort	0.8	1.2	3.1	1.8	1.1	-0.7	-0.7	1.0
Had major operations	2.3	2.7	9.9	-0.3	-0.7	-3.1	0.1	-1.8
Age at last live birth	1.0	1.5	5.6	-2.4	-0.1	-0.5	1.0	-0.6
Family relationship satisfaction	0.6	0.8	2.2	-1.2	1.5	0.2	-0.6	0.1
Leg pain on walking	0.4	0.5	2.0	1.4	0.2	-0.0	0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	4.8	0.6	2.2	0.9	-2.0	0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	0.7	-1.0	0.1	-0.6	0.8
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.0	-1.2	-1.3	0.6	1.3	-1.4
Medication: Aspirin	0.9	1.2	3.5	1.9	0.1	-0.8	-1.4	0.0
Supplements: Vitamin C	0.3	0.4	0.6	0.8	-0.7	-0.4	-0.6	-0.6
Knee pain experienced in last month	0.4	0.7	1.1	0.8	-0.8	-0.6	0.7	-1.1
Hypertension (Self-reported)	2.2	6.1	9.9	1.8	3.1	1.5	-2.4	3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	-0.7	0.5	0.2	0.7	-0.4
Illnesses of father: Heart disease	0.5	0.7	1.7	0.7	-0.9	-0.1	-1.3	-0.7
Illnesses of siblings: Diabetes	0.6	0.8	2.2	-0.1	0.1	-1.5	0.1	-1.3
Smoking status: Previous	0.9	1.3	4.5	2.1	-0.5	0.8	-1.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.7	10.8	-3.2	0.8	3.3	-0.7	1.2
Whole body fat-free mass	1.0	5.9	11.0	-3.3	2.0	2.4	-2.1	2.1
Leg fat-free mass (right)	1.1	5.8	9.4	-2.5	2.0	3.1	-2.6	1.7
Arm fat percentage (left)	0.8	3.0	11.1	3.3	0.7	0.3	-1.5	-1.0
Average weekly red wine intake	0.5	0.7	2.4	-0.7	0.8	1.6	-0.1	0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.9	0.9	0.8	0.6	-0.6	0.9
Mood swings	1.0	1.8	3.6	1.0	1.9	1.4	-0.7	1.3
Loneliness, isolation	0.7	0.9	1.5	-0.9	1.2	-0.2	-1.0	1.1
Long-standing illness, disability or infirmity	2.9	4.5	12.7	3.6	1.5	-1.9	-1.9	-0.2
Ever had bowel cancer screening	1.0	1.2	4.3	0.4	-0.3	-2.1	1.1	-0.0
Diabetes diagnosed by doctor	1.4	2.3	8.4	2.9	1.6	-0.4	-0.3	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	4.0	-1.1	-0.3	-1.5	2.0	-0.4
Friendships satisfaction	0.7	0.9	1.3	-1.1	1.0	-0.8	1.1	-0.5
Qualifications: nursing, teaching	0.2	0.3	1.2	-0.3	0.1	1.1	0.2	-0.3
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.5	0.5	-0.5	0.0	-0.5
Eye problems/disorders: Cataract	0.7	0.8	2.4	1.6	-0.7	-0.7	-0.3	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.6	0.2	-0.3	-1.1	1.6	-1.3
Medication for cholesterol	3.0	4.6	7.8	-2.8	-2.7	0.4	2.2	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.7	1.3	0.1	-1.2	0.6	1.1
Back pain experienced in last month	0.5	0.8	1.6	0.6	0.9	-0.4	-1.3	0.9
Mineral and other dietary supplements	0.8	1.1	2.9	-1.4	1.7	0.1	-0.3	0.8
Breast cancer (self-reported)	0.2	0.2	0.5	-0.2	0.7	0.0	-0.6	0.1
Asthma (self-reported)	0.2	0.4	1.0	-0.4	0.5	-1.0	-0.5	-0.2
Osteoporosis (self-reported)	1.9	2.4	6.3	0.5	0.4	0.6	-2.5	2.2
Osteoarthritis (self-reported)	1.0	1.3	3.9	2.0	-0.4	-0.7	1.1	-0.9
Medication: Aspirin	0.9	1.2	4.2	2.1	0.2	-0.6	-1.1	0.4
Medication: Gliclazide	1.3	1.5	5.2	2.3	1.2	0.6	-0.8	0.2
Illnesses of father: None of the above (group 1)	1.2	1.5	4.2	-2.1	0.1	1.1	1.3	-0.7
Smoking status: Current	0.3	0.5	1.7	-0.4	-0.6	1.3	0.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	0.6	-0.2	0.6	-0.4	0.9
Whole body water mass	1.1	6.3	11.5	-3.4	2.0	2.5	-2.2	2.2
Leg predicted mass (right)	1.1	5.7	9.4	-2.4	2.0	3.1	-2.6	1.7
Arm fat mass (left)	0.4	1.8	3.3	1.8	1.3	1.0	-1.8	-0.1
Number of self-reported non-cancer illnesses	3.5	6.1	20.9	4.6	1.0	-1.3	-2.3	1.1
Average weekly champagne plus white wine intake	0.9	1.2	4.8	-1.0	0.2	0.3	-2.2	-0.0
Miserableness	0.3	0.4	1.0	-0.4	0.0	0.9	-1.0	0.4
Guilty feelings	0.4	0.6	1.5	-1.2	0.2	0.8	-0.6	-0.7
Wears glasses or contact lenses	1.8	2.0	4.6	0.0	0.7	2.0	-0.9	2.1
Ever taken oral contraceptive pill	0.4	0.4	1.9	1.4	0.4	-0.1	0.3	0.3
Hearing aid user	1.6	1.8	4.8	2.2	-0.3	1.1	-0.9	1.4
Mother’s age at death	1.5	1.9	5.8	0.2	-0.9	-1.7	-0.2	-2.4
Financial situation satisfaction	0.7	0.9	3.7	0.3	0.3	-0.7	-1.9	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.8	1.5	1.2	-1.2	-0.8	-0.3	-0.4
Commuting to job workplace: Public transport	1.2	1.5	2.4	-1.6	-0.4	-1.1	1.1	-1.5
Eye problems/disorders: Glaucoma	0.9	1.0	3.0	-0.5	-1.0	-1.7	0.7	-0.6
Medication: Blood pressure	2.3	4.4	11.4	3.4	2.3	0.3	-1.5	1.7
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.0	0.9	-0.7	-0.5	-1.4	-0.2
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.4	1.5	-1.6	-0.1	-0.7	-0.7
High cholesterol (Self-reported)	1.4	2.6	6.8	2.6	1.7	-0.0	-1.6	0.6
Medication: Bendroflumethiazide	1.5	2.3	3.3	0.8	1.5	1.8	-1.5	1.8
Medication: Paracetamol	0.8	1.3	4.7	1.0	0.5	-2.2	0.3	-0.6
Medication: Lisinopril	1.1	1.5	4.0	-0.3	1.2	2.0	0.2	1.3
Medication: Atorvastatin	3.1	3.8	16.6	4.1	0.2	-0.1	-1.1	1.0
Illnesses of father: High blood pressure	0.7	0.9	1.7	1.3	0.2	-0.4	1.3	0.9
Alcohol drinker status: Never	0.5	0.6	1.2	1.0	1.1	0.4	0.5	0.6
Ever smoked	1.3	2.2	6.8	-0.2	0.8	2.6	-1.0	1.6
Basal metabolic rate	0.9	4.8	7.2	-2.7	1.9	2.4	-2.0	1.8
Leg fat percentage (left)	0.7	2.5	10.0	3.2	0.3	-0.5	-1.2	-0.9
Arm fat-free mass (left)	1.1	5.4	9.6	-3.1	2.2	2.0	-1.9	2.2
Number of operations (self-reported)	1.2	1.8	6.6	1.3	-0.0	-2.6	0.6	0.4
Average weekly beer plus cider intake	0.5	0.8	1.9	-0.5	0.1	0.8	1.4	1.0
Irritability	0.2	0.4	1.0	0.3	1.0	0.8	0.2	0.3
Risk taking	1.2	1.7	4.3	-2.1	-0.7	-1.3	0.3	-1.4
Ever had prostate specific antigen (PSA) test	2.8	3.2	9.1	-0.2	-3.0	-0.7	1.7	-1.8
Fractured/broken bones in last 5 years	0.9	1.2	2.4	1.6	-0.2	-0.8	-1.5	0.7
Age started oral contraceptive pill	0.4	0.5	1.0	-0.6	0.9	-1.0	0.3	-0.3
Diastolic blood pressure, automated reading	1.4	4.2	8.4	1.7	2.5	0.7	-1.7	2.9
Ever depressed for a whole week	1.5	1.8	3.8	-1.2	-0.2	-1.9	0.8	-1.8
Unable to work because of sickness or disability	1.7	2.2	6.9	2.6	0.8	-0.2	-0.1	1.8
Commuting to job workplace: Cycle	1.5	1.8	4.8	-0.1	-2.2	-0.9	0.9	-1.5
Myopia	0.6	0.8	1.5	1.2	0.6	-0.6	-1.0	1.0
Vascular/heart problems diagnosed by doctor	1.7	4.5	7.4	-2.1	-2.7	-0.8	2.0	-2.4
Cholesterol lowering medication	3.6	5.2	14.5	3.8	2.9	-0.8	-0.5	1.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.9	1.7	0.0	-0.8	-1.6	0.6
Pain experienced in last month	1.6	2.7	4.8	0.1	-1.6	2.2	2.1	1.4
Supplements: Calcium	2.3	2.5	4.9	2.2	-2.1	-1.6	-0.2	-0.8
Basal cell carcinoma (self-reported)	0.7	0.8	1.6	-1.1	0.5	-1.3	0.7	-0.8
Heart attack/myocardial infarction (self-reported)	1.3	1.6	5.4	2.3	0.0	-1.1	0.7	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	7.5	0.0	1.5	1.0	-1.1	2.7
Heart disease (siblings)	2.0	2.5	5.5	2.0	1.1	-2.3	-0.5	1.2
Alcohol drinker status: Previous	0.1	0.1	0.3	0.0	-0.6	0.4	-0.1	0.1
Pack years of smoking	0.4	0.5	1.3	-0.4	0.8	-0.6	-1.2	0.2
Impedance of whole body	0.7	3.5	6.4	-1.3	-2.0	-0.6	2.5	-2.2
Leg fat mass (left)	0.4	1.5	2.9	1.7	1.0	0.8	-1.7	-0.1
Arm predicted mass (left)	0.9	4.7	9.3	-3.0	1.9	1.9	-1.6	2.0