TWAS hub - BCAT2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.3330	0.1000	3.5e-03	0.122	NA	0.079	NA	0.080	3.7e-04	NA	3.9e-03	NA	3.6e-03
2	GTEx	Stomach	0.4000	0.0760	1.5e-05	0.236	NA	0.198	NA	0.236	1.3e-11	NA	8.0e-10	NA	1.3e-11
3	METSIM	Adipose	0.0826	0.0322	3.3e-03	0.080	0.008	0.064	0.076	0.070	4.9e-12	0.021	6.1e-10	1.6e-11	1.1e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Aspirin	4.4	5.8	8.9	1.2	2.7	-3.0
HbA1C	3.4	3.8	10.7	-0.5	0.6	3.3
Comparative body size at age 10	3.4	9.3	22.4	-0.4	-4.7	-2.3
Chronotype (morning person)	2.9	6.7	17.0	1.0	-4.1	-1.4
Medication: Lansoprazole	2.8	3.2	7.1	1.0	-2.7	-1.2
Medication: Aspirin	2.7	3.6	5.5	1.3	1.9	-2.3
Illnesses of siblings	2.5	3.5	9.3	1.1	-3.1	-0.1
Weight	2.3	11.2	17.1	4.1	-3.1	-2.6
Mouth/teeth dental problems: Dentures	2.3	3.9	9.8	0.5	3.1	-1.3
Number of children fathered	2.3	2.6	7.2	0.7	-2.7	-0.2
Guilty feelings	2.3	3.4	7.1	-1.5	2.7	1.0
Migraine (self-reported)	2.2	2.7	6.2	2.5	-1.4	0.3
Commuting to job workplace: Public transport	2.2	2.7	3.7	1.8	-1.0	1.9
Medication: Simvastatin	2.1	3.1	6.7	1.6	2.6	-0.3
Hip circumference	2.1	9.0	13.8	3.7	-2.8	-2.3
Arm fat-free mass (right)	2.1	10.9	15.1	3.9	-3.3	-2.6
Basal metabolic rate	2.1	11.8	17.6	4.2	-3.0	-3.0
Arm fat-free mass (left)	2.1	10.6	12.9	3.6	-3.1	-3.0
Average weekly beer plus cider intake	2.1	3.0	7.1	-1.4	2.7	0.3
Alcohol drinker status: Previous	2.1	2.4	3.5	1.6	-1.9	-1.1
Arm predicted mass (left)	2.1	10.8	13.3	3.6	-2.9	-3.2
Supplements: Zinc	2.0	2.2	5.1	1.2	-2.3	0.0
Leg fat-free mass (left)	2.0	10.5	17.9	4.2	-2.5	-2.7
Hand grip strength (right)	2.0	5.5	11.7	3.4	-2.0	0.9
Leg predicted mass (left)	2.0	10.4	17.4	4.2	-2.6	-2.7
Had other major operations	2.0	2.5	4.2	0.2	2.1	-1.8
Trunk fat-free mass	2.0	11.5	15.0	3.9	-3.1	-3.1
Prospective memory result	2.0	2.4	6.7	-0.7	-0.3	-2.6
Trunk predicted mass	2.0	11.5	14.7	3.8	-3.2	-3.1
Arm predicted mass (right)	2.0	10.1	12.8	3.6	-3.4	-2.5
Whole body fat-free mass	2.0	11.7	16.0	4.0	-3.1	-3.0
Whole body water mass	2.0	11.3	15.5	3.9	-3.0	-3.1
Past tobacco smoking	1.9	3.5	7.0	-1.8	0.3	2.6
Supplements: Vitamin C	1.9	2.3	4.3	-0.8	-2.1	1.3
Leg fat-free mass (right)	1.9	10.1	17.0	4.1	-2.9	-2.2
Average weekly spirits intake	1.8	2.2	5.7	0.5	-2.4	-0.8
Commuting to job workplace: Walk	1.8	1.9	4.0	0.6	1.2	2.0
Leg predicted mass (right)	1.8	9.8	16.6	4.1	-2.8	-2.3
Alcohol intake frequency.	1.7	3.9	10.8	1.0	-3.3	0.3
Trunk fat mass	1.6	6.8	12.9	3.6	-2.2	-1.6
Hair/balding pattern: Pattern 3	1.6	2.4	4.5	-2.1	1.3	1.1
High blood pressure (siblings)	1.6	2.3	4.3	-2.1	1.6	0.2
Leg fat mass (left)	1.6	6.4	10.8	3.3	-2.1	-2.0
Hand grip strength (left)	1.5	4.1	7.8	2.8	-2.0	0.6
Leg fat mass (right)	1.5	6.0	10.6	3.3	-1.7	-2.1
Comparative height size at age 10	1.5	8.5	12.6	3.2	-3.5	-1.7
Smoking status: Previous	1.5	2.2	3.7	1.7	-0.4	-1.9
Arm fat mass (left)	1.5	6.2	9.7	3.1	-2.0	-2.3
Average weekly champagne plus white wine intake	1.5	2.0	3.7	0.7	1.9	-1.4
Mouth/teeth dental problems	1.4	2.1	4.1	-0.7	-2.0	-1.3
Father’s age at death	1.4	1.9	4.3	-0.2	-1.2	-2.1
Medication: Ibuprofen	1.4	1.7	3.1	-0.1	1.4	-1.8
Whole body fat mass	1.4	6.0	10.4	3.2	-2.1	-1.7
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.0	-1.7	0.2	-1.3
Tinnitus: Yes, now most or all of the time	1.4	1.6	2.9	1.7	-1.2	0.8
Relative age of first facial hair	1.3	2.6	7.7	0.3	2.8	-0.1
Medication: Ramipril	1.3	1.7	3.7	1.9	1.0	-0.6
Qualifications: A levels/AS levels or equivalent	1.3	3.0	4.7	2.2	1.6	1.3
Medication: Cholesterol lowering	1.3	2.0	5.6	0.1	2.4	-0.7
Standing height	1.3	12.7	28.0	5.3	-3.1	-0.8
Headache pain in last month	1.3	2.2	4.6	1.4	2.1	-0.1
Number of full sisters	1.3	1.5	2.5	-0.9	1.2	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.8	0.5	-0.8	-1.9
Loneliness, isolation	1.3	1.8	4.3	-0.3	2.1	-0.9
Ever smoked	1.3	2.2	5.4	1.0	-0.4	-2.3
Basal cell carcinoma (self-reported)	1.3	1.5	3.5	1.9	-1.0	0.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	5.0	2.2	0.3	0.3
Pack years of smoking	1.3	1.9	2.7	-0.7	1.6	-1.6
Mean Putamen Volume	1.2	1.4	4.1	0.2	-0.0	-2.0
Lupus	1.2	1.8	4.4	-2.1	-0.7	-0.5
Cardiovascular Disease	1.2	4.0	10.1	-0.3	3.2	1.3
Pack years adult smoking proportion	1.2	1.8	2.6	-0.9	1.6	-1.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	3.3	-1.8	0.6	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	4.6	1.2	-2.1	1.5
Medication: Levothyroxine sodium	1.2	2.0	2.6	1.1	1.5	1.6
Sitting height	1.2	8.3	15.0	3.9	-3.1	-0.7
Impedance of arm (right)	1.2	5.4	9.1	-1.1	3.0	2.4
Arm fat mass (right)	1.2	5.0	7.4	2.7	-1.5	-2.3
Age at first live birth	1.2	2.1	3.0	1.7	1.7	-0.6
Medication: Blood pressure	1.2	2.2	5.3	2.3	0.6	-0.9
Medication: Allopurinol	1.2	1.5	3.0	1.2	0.3	-1.7
Qualifications: nursing, teaching	1.2	1.9	3.3	0.7	-1.8	1.3
Medication: Gliclazide	1.2	1.3	3.2	-0.8	-0.4	1.8
Cholesterol lowering medication	1.2	1.8	5.1	0.6	2.3	-0.2
Schizophrenia (2018)	1.1	2.3	4.0	1.2	2.0	1.2
Smoking Status	1.1	2.7	6.0	1.3	0.6	-2.4
Hypothyroidism (self reported)	1.1	2.5	7.2	-0.1	2.7	0.4
High blood pressure (mother)	1.1	1.6	3.1	-0.0	1.8	1.3
Waist circumference	1.1	4.1	4.9	2.1	-1.7	-2.2
Hair/balding pattern: Pattern 2	1.1	1.4	2.7	0.9	-1.6	0.8
Pulse wave reflection index	1.1	1.3	3.3	-0.8	-0.0	-1.8
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	4.4	1.1	2.1	0.8
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.1	0.7	-0.7	-1.8
Medication for pain relief, constipation, heartburn	1.1	1.9	3.8	-0.8	-1.2	2.0
Medication: Seretide 50 evohaler	1.1	1.3	3.3	-0.7	-1.8	-0.1
Diabetes diagnosed by doctor	1.1	1.8	4.1	-1.1	2.0	0.4
Medication for cholesterol	1.1	1.7	3.1	-0.9	-1.8	-1.0
Unable to work because of sickness or disability	1.1	1.4	2.5	-1.0	0.7	-1.6
Impedance of whole body	1.1	5.4	12.1	-0.9	1.8	3.5
Major Depression (MDD)	1.0	1.2	2.0	0.0	1.4	1.3
Rheumatoid Arthritis	1.0	1.4	1.9	0.7	1.3	-1.4
Waist Hip Ratio (WHR)	1.0	4.4	8.9	-1.8	3.0	-1.0
Medication: Co-codamol	1.0	1.2	2.1	1.4	-0.4	1.1
Stomach or abdominal pain in last month	1.0	1.2	1.8	-1.4	1.3	-0.2
Body mass index (BMI)	1.0	4.2	5.7	2.0	-1.8	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	3.1	0.9	-1.6	1.8
Heart attack	1.0	1.3	3.5	1.9	0.6	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	1.8	0.8	1.3	1.1
Length of working week for main job	1.0	1.1	2.8	0.0	-0.8	-1.7
Breastfed as a baby	1.0	1.3	2.8	-0.5	-0.9	-1.7
Medication: Amlodipine	1.0	1.3	3.0	1.7	-0.4	-0.9
Heart disease (mother)	1.0	1.2	1.5	1.2	-1.1	0.9
Friendships satisfaction	1.0	1.3	2.6	-1.0	1.6	0.5
Number of self-reported non-cancer illnesses	1.0	1.7	2.8	0.9	1.7	-1.2
Heart disease (siblings)	1.0	1.2	3.1	-0.6	1.8	-0.3
BMI	0.9	5.0	8.2	1.9	-2.9	-1.9
Vitamin and mineral supplements	0.9	1.2	2.4	1.0	1.5	-0.4
Supplements: Glucosamine	0.9	1.2	1.8	1.3	-1.2	-0.6
Impedance of leg (left)	0.9	4.3	8.6	-1.3	1.6	2.9
Forced vital capacity (FVC)	0.9	3.6	7.0	2.6	-1.4	1.3
Falls in the last year	0.9	1.2	2.5	-0.4	-1.0	1.6
Illnesses of mother	0.9	1.1	2.1	-1.1	-0.4	-1.4
Impedance of arm (left)	0.9	4.3	9.6	-0.2	1.8	3.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	1.8	-1.0	-1.3	1.3
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.4	-1.6	0.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.5	-1.2	1.1	0.6
Had major operations	0.9	1.1	2.8	1.7	0.5	-0.2
Ever had bowel cancer screening	0.9	1.0	2.0	-0.4	1.4	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.7	-0.7	1.3	0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.0	0.8	-1.4	1.0
High cholesterol (Self-reported)	0.9	1.6	3.0	-0.0	1.7	1.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.8	1.1	-1.3	0.3
Commuting to job workplace: Cycle	0.9	1.1	2.9	-0.5	-0.2	-1.7
Pain experienced in last month	0.9	1.5	2.2	-0.9	-1.5	1.2
Neuroticism (2016)	0.8	1.2	2.0	-1.2	-0.2	1.4
Impedance of leg (right)	0.8	4.0	5.7	-1.4	2.4	2.1
Trunk fat percentage	0.8	3.3	7.2	2.7	-1.3	-1.0
Maternal smoking around birth	0.8	1.1	2.7	0.8	-0.1	-1.6
Relative age voice broke	0.8	1.2	3.4	0.2	1.9	-0.2
Nervous feelings	0.8	1.5	2.5	-1.4	1.6	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.9	0.0	1.3	-1.4
Pain all over the body in last month	0.8	0.8	1.5	1.2	-0.4	-0.9
Pulse wave Arterial Stiffness index	0.8	0.9	2.1	-0.5	-0.7	-1.4
Tense / ‘highly strung’	0.8	1.4	2.4	1.2	1.5	0.3
Forced vital capacity (FVC), Best measure	0.8	2.9	7.4	2.7	-0.5	1.0
Body fat percentage	0.8	3.0	6.1	2.5	-1.4	-1.1
Leg pain on walking	0.8	1.0	2.3	0.6	-0.4	1.5
Knee pain experienced in last month	0.8	1.3	2.9	1.7	1.0	-0.0
Arm fat percentage (left)	0.8	3.3	5.8	2.4	-1.4	-1.5
Long-standing illness, disability or infirmity	0.8	1.2	3.4	0.2	1.9	-0.5
Risk taking	0.8	1.2	3.2	0.2	1.8	-0.6
Depressed Affect (Nagel 2018)	0.7	1.6	2.2	0.9	1.3	-1.5
Depression (Nagel 2018)	0.7	1.1	1.6	1.3	-0.3	-1.2
Crohns Disease (2017)	0.7	1.4	2.8	1.1	-0.6	1.7
Fasting Glucose	0.7	0.9	1.4	1.2	-0.6	-0.9
Height	0.7	13.2	19.9	4.5	-4.2	-1.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.4	-1.2	1.0	-0.5
Angina	0.7	0.9	2.4	-0.5	0.1	-1.6
Diabetes (father)	0.7	0.9	2.6	0.3	0.3	-1.6
Age when periods started (menarche)	0.7	1.6	2.7	1.6	-0.4	1.4
Multivitamins +/- minerals	0.7	0.9	1.9	-0.8	-1.4	-0.1
Arm fat percentage (right)	0.7	2.6	3.6	1.9	-0.8	-1.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.3	1.8	-1.5	1.2
Birth weight of first child	0.7	1.3	1.9	-1.4	1.2	-0.8
Loud music exposure frequency	0.7	0.7	1.5	1.2	0.5	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.4	-1.0	0.5	1.2
Pulse wave peak to peak time	0.7	0.8	1.6	0.8	0.4	1.2
Emphysema/chronic bronchitis	0.7	0.8	1.2	-0.9	1.1	0.5
Mineral and other dietary supplements	0.7	0.9	1.9	-0.9	1.4	0.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.3	-0.4	-1.1	1.1
Miserableness	0.7	1.2	3.1	-0.6	1.8	-0.4
Leg fat percentage (left)	0.7	2.6	4.0	2.0	-1.6	-1.1
Myopia	0.7	1.1	1.7	-1.3	-0.8	0.9
Worry (Nagel 2018)	0.6	1.2	2.7	0.5	0.9	-1.6
Schizophrenia (2014)	0.6	1.2	2.2	1.1	1.5	0.5
Ulcerative Colitis	0.6	0.8	2.4	-1.5	0.0	-0.3
Allergy or Eczema	0.6	1.5	2.5	1.3	-1.6	-0.5
Neuroticism	0.6	1.5	2.5	0.2	1.6	-1.4
Severe depression (siblings)	0.6	0.7	1.4	0.8	1.2	-0.2
Average weekly fortified wine intake	0.6	0.7	1.2	0.9	-0.2	1.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.1	1.0	0.4	1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.2	1.1	-1.0	0.4
Number of live births	0.6	0.8	2.0	-1.4	-0.6	0.2
Happiness	0.6	0.8	1.8	-0.3	0.6	1.3
Asthma	0.6	1.2	1.7	-0.7	-1.3	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.3	-0.0	1.0	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.2	2.0	-0.6	1.0
Exposure to tobacco smoke at home	0.6	0.7	0.9	1.0	-0.8	-0.7
Hair/balding pattern: Pattern 4	0.6	1.4	2.0	1.1	-1.0	-1.4
Leg fat percentage (right)	0.6	2.1	3.6	1.9	-0.8	-1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.7	0.6	-0.4	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.7	1.6	1.1	0.0
Asthma (self-reported)	0.6	1.3	1.8	-0.4	-1.4	-1.4
Osteoporosis (self-reported)	0.6	0.8	1.6	-0.5	1.2	0.7
Smoking status: Current	0.6	1.0	2.3	0.0	0.9	-1.5
Wears glasses or contact lenses	0.6	0.7	1.7	1.3	0.4	-0.6
Medication: Paracetamol	0.6	0.9	1.6	0.7	0.8	-1.3
Number of operations (self-reported)	0.6	0.9	2.0	0.2	0.9	-1.4
Neuroticism (Nagel 2018)	0.5	1.1	1.6	0.5	1.3	-1.2
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	-0.4	1.2	0.2
Ulcerative Colitis (UC)	0.5	0.9	2.0	-0.7	-1.4	0.4
HDL Cholesterol	0.5	0.8	1.2	-0.9	-0.5	1.1
Blood Eosinophil Count	0.5	3.9	6.9	2.6	2.1	-0.6
Systolic Blood Pressure	0.5	2.7	5.2	-1.4	2.3	1.0
Number of treatments/medications taken	0.5	0.9	1.8	0.4	0.9	-1.3
Sensitivity / hurt feelings	0.5	0.8	1.9	1.4	0.7	-0.4
Medication: Metformin	0.5	0.7	1.5	-1.2	0.6	-0.5
Diabetes (mother)	0.5	0.7	1.4	0.8	0.2	-1.2
Current tobacco smoking	0.5	0.8	1.7	0.1	0.9	-1.3
Fed-up feelings	0.5	0.9	2.1	0.5	1.4	-0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.7	0.5	0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	1.3	0.4	-0.1
Medication: Atenolol	0.5	0.6	1.0	1.0	0.6	-0.7
Diabetes (self-reported)	0.5	0.8	1.8	-0.8	1.4	-0.2
Fluid intelligence score	0.5	1.0	1.5	0.5	1.1	-1.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	0.9	0.1	-0.9
Medication: Paracetamol	0.5	0.9	1.5	0.8	0.7	-1.2
Gout (self-reported)	0.5	0.6	0.9	0.9	0.5	-0.9
Birth weight	0.5	1.0	1.9	0.9	-0.5	-1.4
Shortness of breath walking on level ground	0.5	0.6	1.2	-0.0	-0.8	1.1
Overall health rating	0.5	1.0	2.4	-0.5	0.7	1.5
Chest pain or discomfort	0.5	0.7	1.7	-0.7	1.3	0.1
Family relationship satisfaction	0.5	0.6	0.7	-0.8	0.9	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	-1.1	-0.4	-0.6
Mood swings	0.5	1.0	1.5	-1.2	1.0	0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.5	-0.5	0.8	1.2
Ever taken oral contraceptive pill	0.5	0.5	1.5	0.1	-1.2	-0.1
Medication: Lisinopril	0.5	0.7	1.3	-1.1	0.9	-0.0
Medication: Atorvastatin	0.5	0.7	1.3	-1.1	0.9	-0.2
Illnesses of father: High blood pressure	0.5	0.7	1.7	0.5	0.3	-1.3
Age started oral contraceptive pill	0.5	0.7	0.9	0.9	-1.0	-0.5
Ever depressed for a whole week	0.5	0.6	1.4	0.6	-0.2	1.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	0.1	1.3	0.3
Irritable Bowel Disease (IBD)	0.4	1.0	1.6	0.2	-1.2	1.2
Reaction Time	0.4	0.8	2.0	1.4	0.6	-0.2
Breast Cancer	0.4	1.1	1.6	1.2	-0.4	-1.3
Ovarian Cancer	0.4	0.6	1.2	0.1	-0.7	1.1
Age at First Birth	0.4	0.6	1.1	0.8	0.2	1.1
Crohns Disease (2012)	0.4	0.7	1.8	1.4	-0.2	0.3
Blood Platelet Count	0.4	4.5	10.4	1.8	3.2	0.2
Blood Red Count	0.4	3.6	7.1	2.7	-1.4	-1.3
Heel T-Score	0.4	2.8	7.8	0.6	-2.8	-0.6
Respiratory disease	0.4	0.9	2.7	-0.1	-1.6	-0.3
Lung FEV1/FVC ratio	0.4	2.2	4.8	-2.2	-1.3	-0.3
Lung FVC	0.4	2.1	3.7	1.9	-1.2	1.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.5	1.2	-1.0	-0.2
Allergy	0.4	0.8	1.2	-0.5	1.1	1.0
Neuroticism score	0.4	0.8	2.2	0.0	1.5	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	-0.1	-1.2	0.5
Peak expiratory flow (PEF)	0.4	0.9	1.6	1.2	-1.0	0.0
Glaucoma (self-reported)	0.4	0.5	0.8	-0.9	-0.3	0.7
Number of full brothers	0.4	0.6	1.5	-1.2	-0.2	0.3
Worry too long after embarrassment	0.4	0.7	2.0	0.0	1.4	-0.4
Wheeze or whistling in the chest in last year	0.4	0.8	2.0	-0.6	0.0	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	1.1	-0.2	-0.5
Eye problems/disorders: None of the above	0.4	0.4	1.1	0.4	-0.2	1.0
Angina (self-reported)	0.4	0.6	1.6	-0.1	-0.2	-1.3
Mean time to correctly identify matches	0.4	0.7	1.0	1.0	0.4	-1.0
Hypertension (Self-reported)	0.4	1.1	3.1	0.5	1.8	0.2
Eye problems/disorders: Cataract	0.4	0.5	1.1	-0.6	0.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	1.5	0.3	-0.8	1.2
Financial situation satisfaction	0.4	0.6	1.5	-0.1	1.2	0.4
Medication: Blood pressure	0.4	0.7	1.6	-1.3	0.7	0.5
Alcohol drinker status: Never	0.4	0.5	0.8	-0.1	0.9	0.8
Irritability	0.4	0.6	1.2	0.8	0.0	1.1
Fractured/broken bones in last 5 years	0.4	0.6	1.0	0.8	1.0	0.2
Supplements: Calcium	0.4	0.5	1.0	1.0	0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.8	0.9	-0.3	1.4
Prostate Cancer	0.3	0.4	0.7	-0.8	-0.7	-0.2
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	1.0	-0.1	-0.4
Primary Biliary Cirrhosis	0.3	0.4	1.1	-0.4	-1.1	-0.0
Triglycerides	0.3	0.4	1.0	-0.3	0.4	-1.0
Blood White Count	0.3	2.1	4.1	2.0	1.4	-0.7
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.9	0.9	0.6	0.3
Systolic blood pressure, automated reading	0.3	0.9	2.0	-0.1	1.4	0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.7	0.6	0.1	0.8
Townsend deprivation index at recruitment	0.3	0.5	1.0	1.0	0.5	-0.2
Taking other prescription medications	0.3	0.4	0.9	0.5	-0.0	-0.9
Qualifications: CSEs or equivalent	0.3	0.5	0.8	-0.9	0.7	0.4
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-1.0	0.5	-0.0
Alcohol usually taken with meals	0.3	0.4	0.8	0.9	0.7	-0.2
Time employed in main current job	0.3	0.3	0.8	-0.1	-0.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	-0.9	0.6	-0.6
Health satisfaction	0.3	0.4	0.7	0.7	-0.3	0.8
Illnesses of father: Heart disease	0.3	0.4	1.0	-0.6	1.0	0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.6	-0.3	0.7	0.7
Back pain experienced in last month	0.3	0.5	1.1	0.5	0.4	-1.1
Medication: Bendroflumethiazide	0.3	0.5	0.8	-0.2	0.8	0.9
Diastolic blood pressure, automated reading	0.3	1.1	3.1	1.8	0.4	-0.1
Bipolar Disorder (2018)	0.2	0.3	0.9	0.2	0.9	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.5	1.2	0.0	0.3
Schizophrenia vs Biploar Disorder	0.2	0.3	1.0	0.0	0.0	1.0
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.3	0.7	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	0.1	0.6	-1.0
LDL Cholesterol	0.2	0.4	0.7	-0.4	0.5	0.9
Hearing difficulty/problems: Yes	0.2	0.4	0.7	-0.9	0.0	-0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.3	-0.5	-0.6
Medication for hormone replacement therapy	0.2	0.3	0.4	0.6	0.2	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.5	0.7	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	0.3	0.6	0.5
Hearing difficulty/problems with background noise	0.2	0.4	0.7	0.2	0.6	-0.9
Financial difficulties in last 2 years	0.2	0.3	0.3	-0.5	-0.6	0.4
Noisy workplace	0.2	0.3	0.7	-0.5	0.8	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	0.0	-0.4	0.9
Exposure to tobacco smoke outside home	0.2	0.3	0.8	-0.1	0.9	-0.3
Qualifications: College or University degree	0.2	0.5	0.7	0.9	0.8	-0.0
Neck or shoulder pain in last month	0.2	0.3	0.7	0.9	0.2	-0.4
Pulse rate, automated reading	0.2	0.7	1.4	0.8	-0.4	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.4	0.1	-0.6
Breast cancer (self-reported)	0.2	0.3	0.3	-0.6	-0.4	-0.6
Mother’s age at death	0.2	0.2	0.5	-0.1	-0.2	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.7	-0.3	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.8	0.1	-0.9	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	0.7	-0.3	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	-0.2	0.8	0.1
Tanning	0.1	0.9	1.6	1.3	0.9	0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.2	0.3	0.5	-0.5
High blood pressure	0.1	0.3	0.5	0.2	0.7	0.4
Number of incorrect matches in round	0.1	0.2	0.5	0.7	-0.3	-0.2
Had menopause	0.1	0.1	0.1	-0.1	0.4	0.3
Worrier / anxious feelings	0.1	0.1	0.2	-0.1	0.5	0.2
Pulse rate	0.1	0.2	0.3	-0.2	-0.6	0.5
Depression (self-reported)	0.1	0.2	0.4	0.1	0.6	-0.2
Lung cancer (father)	0.1	0.2	0.3	-0.3	0.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.4	0.4	0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.4	-0.1	0.5
Medication: Omeprazole	0.1	0.2	0.5	0.7	-0.1	0.0
Age at last live birth	0.1	0.2	0.4	-0.4	0.6	-0.3
Average weekly red wine intake	0.1	0.2	0.3	0.4	0.4	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.1	0.5	0.0
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.6	0.1	0.2
Hearing aid user	0.1	0.1	0.3	0.6	-0.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.3	-0.2	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.4	0.5	-0.7	-0.5	-0.5
Qualifications: None of the above	0.0	0.1	0.2	0.0	0.3	0.4
Alcohol intake versus 10 years previously	0.0	0.1	0.1	-0.0	0.3	-0.3
Suffer from ‘nerves’	0.0	0.0	0.0	-0.1	-0.0	0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.3	0.1	-0.1
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.2	-0.1	0.2

Hub : Genes

BCAT2

Models

Trait associations