TWAS hub - TBC1D17

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.4350	0.1320	1.2e-03	-0.010	NA	0.018	NA	0.022	0.62000	NA	0.12000	NA	0.1000
2	GTEx	Cells Transformed fibroblasts	0.1110	0.0350	6.5e-05	0.033	NA	0.039	NA	0.036	0.00160	NA	0.00065	NA	0.0011
3	TCGA	Brain Lower Grade Glioma	0.0592	0.0305	1.2e-04	0.026	0.023	0.015	NA	0.020	0.00052	0.00095	0.00720	NA	0.0022

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Migraine (self-reported)	7.4	9.1	13.2	1.1	3.6	3.6
Medication: Metformin	6.1	8.6	13.4	-2.4	-2.5	-3.7
Medication: Lansoprazole	5.9	6.7	12.5	0.1	-2.8	-3.5
Trunk fat-free mass	4.5	26.0	49.6	0.9	7.0	5.2
Trunk predicted mass	4.5	26.0	49.3	1.0	7.0	5.3
Frequency of tenseness / restlessness in last 2 weeks	4.4	6.8	8.6	-2.6	-2.2	-2.9
Impedance of arm (left)	4.1	19.0	25.3	-2.6	-5.0	-5.0
Medication: Ibuprofen	4.0	4.8	7.6	1.3	2.2	2.8
Impedance of whole body	4.0	20.5	28.9	-2.3	-5.4	-5.2
Medication: Ibuprofen (e.g. Nurofen)	3.9	5.0	9.5	1.3	1.9	3.1
Age at First Birth	3.7	5.4	8.6	-1.7	-2.2	-2.9
Had menopause	3.7	4.6	8.5	-0.2	-2.3	-2.9
Arm predicted mass (left)	3.7	18.7	36.1	0.7	6.0	4.4
Neuroticism	3.6	8.7	11.0	-3.3	-2.5	-2.9
Current tobacco smoking	3.6	6.0	9.1	1.5	3.0	2.6
Impedance of arm (right)	3.6	17.0	24.0	-2.7	-4.5	-4.9
Whole body fat-free mass	3.5	20.2	39.4	0.6	6.3	4.5
Smoking status: Current	3.5	5.6	8.4	1.5	2.9	2.5
Whole body water mass	3.5	20.1	39.2	0.6	6.3	4.6
Relative age voice broke	3.4	5.2	7.3	-2.7	-1.9	-2.2
Worry too long after embarrassment	3.4	5.8	7.6	-2.8	-2.1	-2.3
Illnesses of father: High blood pressure	3.4	4.2	6.6	1.6	2.6	1.9
Arm fat-free mass (left)	3.3	16.6	32.9	0.7	5.7	4.0
Sitting height	3.2	23.0	49.0	0.1	7.0	4.5
Medication: Ramipril	3.2	4.1	9.3	-1.2	-1.2	-3.0
Fluid intelligence score	3.2	6.6	10.2	-3.2	-1.2	-2.9
Worry (Nagel 2018)	3.1	6.5	8.1	-2.8	-2.2	-2.6
Eye problems/disorders: Diabetes related eye disease	3.1	3.5	5.0	-1.9	-2.2	-1.4
Impedance of leg (right)	3.1	15.0	21.7	-1.6	-4.7	-4.6
Basal cell carcinoma (self-reported)	3.1	3.7	4.9	-2.0	-1.5	-2.2
Neuroticism (Nagel 2018)	3.0	7.1	13.3	-3.6	-1.6	-2.3
Arm predicted mass (right)	3.0	15.5	28.7	1.0	5.4	4.1
Diabetes (self-reported)	2.9	4.4	5.3	-1.6	-2.3	-2.3
Arm fat-free mass (right)	2.9	15.1	28.0	0.9	5.3	4.1
Leg pain on walking	2.7	3.4	5.3	1.4	2.3	1.7
Basal metabolic rate	2.7	15.0	30.1	-0.0	5.5	3.9
Diabetes (father)	2.4	2.9	4.2	-1.8	-1.2	-2.0
Impedance of leg (left)	2.4	11.7	18.9	-0.9	-4.3	-3.9
Headache pain in last month	2.4	4.2	11.0	-0.4	3.3	1.2
Leg fat-free mass (right)	2.4	12.9	25.3	-0.0	5.0	3.7
Illnesses of father: None of the above (group 1)	2.4	3.0	6.7	-2.6	-1.5	-0.3
Leg predicted mass (right)	2.4	12.9	25.3	-0.0	5.0	3.7
Forced vital capacity (FVC)	2.3	8.8	17.8	0.9	4.2	2.8
Qualifications: A levels/AS levels or equivalent	2.3	5.1	11.2	0.9	3.3	1.8
Peak expiratory flow (PEF)	2.3	5.4	10.8	0.4	3.3	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	2.9	-1.6	-1.6	-1.7
Mouth/teeth dental problems	2.2	3.3	8.4	0.1	2.9	1.3
Mouth/teeth dental problems: Loose teeth	2.2	2.6	4.5	-0.5	-2.1	-1.8
Average weekly red wine intake	2.2	3.2	5.0	-1.7	-2.2	-1.2
Ever had bowel cancer screening	2.1	2.4	4.4	1.5	-0.8	-2.1
Leg fat-free mass (left)	2.0	10.4	21.8	-0.5	4.7	3.0
Forced expiratory volume in 1-second (FEV1)	2.0	6.6	10.3	1.0	3.2	2.9
Forced vital capacity (FVC), Best measure	2.0	7.1	13.3	0.3	3.6	2.8
Number of full brothers	2.0	2.5	4.8	1.2	1.1	2.2
Trunk fat percentage	1.9	7.7	10.0	-2.7	-2.5	-3.2
Leg predicted mass (left)	1.9	10.2	21.5	-0.5	4.6	3.0
Allergy	1.9	4.5	11.3	-0.2	1.4	3.4
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	5.6	0.0	2.4	1.8
Body fat percentage	1.9	7.4	9.7	-2.5	-2.5	-3.1
Diabetes diagnosed by doctor	1.9	3.1	4.2	-1.4	-1.8	-2.0
Verbal and Numeric Reasoning (VNR)	1.8	4.2	6.5	-2.6	-0.6	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.7	8.7	0.4	2.9	2.9
Leg fat percentage (right)	1.8	6.4	8.7	-2.4	-2.2	-2.9
Average weekly champagne plus white wine intake	1.7	2.4	3.2	-1.2	-1.8	-1.5
Irritability	1.7	2.8	5.9	-2.4	-0.7	-1.5
Commuting to job workplace: Cycle	1.7	2.1	2.8	-1.2	-1.4	-1.7
Hand grip strength (right)	1.6	4.3	8.4	1.4	1.6	2.9
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	2.3	-1.1	-1.5	-1.4
Illnesses of siblings: Diabetes	1.6	1.9	4.3	-0.4	-1.1	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.6	1.2	-1.9	-0.7
Breast Cancer	1.5	3.6	5.3	1.9	-2.3	-1.3
Alcohol usually taken with meals	1.5	2.4	3.7	-1.5	-1.1	-1.9
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.1	-1.1	-1.5	-1.3
Hearing aid user	1.5	1.6	4.0	-2.0	0.7	0.7
Type 2 Diabetes (T2D) (2012)	1.4	1.6	4.7	0.0	0.0	-2.2
Medication: Atenolol	1.4	1.7	2.7	0.3	1.6	1.5
Medication: Cholesterol lowering	1.4	2.2	5.5	-0.8	-0.6	-2.4
Prospective memory result	1.4	1.7	2.8	1.0	1.2	1.7
Length of working week for main job	1.4	1.5	2.8	-1.3	-1.7	-0.1
Myopia	1.4	2.0	3.6	-0.4	-1.9	-1.5
LDL Cholesterol	1.3	2.1	4.5	-2.1	1.3	0.2
Triglycerides	1.3	2.2	3.4	-1.9	1.6	-0.8
Allergy or Eczema	1.3	3.5	7.9	-0.4	-1.5	-2.8
Neuroticism score	1.3	2.8	3.9	-2.0	-1.2	-1.7
Standing height	1.3	13.4	30.8	-0.9	5.5	2.9
Alcohol intake frequency.	1.3	3.0	4.7	0.2	2.2	2.1
Suffer from ‘nerves’	1.3	2.0	2.4	-1.6	-1.3	-1.4
Commuting to job workplace: Walk	1.3	1.4	2.7	-1.1	-0.5	-1.6
Pain type(s) experienced in last month: Hip pain	1.3	1.7	4.2	0.2	2.1	0.9
Smoking Status	1.2	2.8	5.3	0.2	2.3	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	3.8	1.9	0.8	1.9
Mouth/teeth dental problems: Dentures	1.2	2.0	3.9	-0.2	-2.0	-1.5
Hair/balding pattern: Pattern 4	1.2	2.9	4.1	-2.0	-1.5	-1.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.3	-1.5	-1.3	-0.8
Comparative height size at age 10	1.2	6.9	15.6	-0.0	4.0	2.2
Had major operations	1.2	1.4	2.9	-0.9	-0.8	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	5.3	-1.5	2.3	0.5
Wears glasses or contact lenses	1.2	1.4	3.2	-0.3	-1.0	-1.8
Leg fat percentage (left)	1.2	4.4	6.2	-1.8	-1.9	-2.5
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.4	-1.4	0.5	-1.6
Ovarian Cancer	1.1	1.4	3.1	-0.9	-0.6	1.8
Height	1.1	21.1	50.4	0.4	7.1	3.6
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.0	-2.0	-1.1	-0.9
Sensitivity / hurt feelings	1.1	2.0	3.1	-1.7	-0.1	-1.8
Vitamin and mineral supplements	1.1	1.5	2.5	0.8	1.6	1.2
Had other major operations	1.1	1.3	1.7	1.2	1.0	1.3
Illnesses of mother	1.1	1.4	3.1	1.7	-0.7	0.8
Tense / ‘highly strung’	1.1	1.8	3.5	-1.9	-0.9	-1.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.4	0.1	0.9	-1.9
Arm fat percentage (left)	1.1	4.2	5.1	-2.3	-1.8	-2.1
Mood swings	1.1	2.0	4.9	-2.2	-0.5	-0.8
Depressed Affect (Nagel 2018)	1.0	2.0	5.6	-2.4	-0.5	-0.5
Respiratory disease	1.0	2.2	4.6	-0.9	-1.2	-2.1
Hand grip strength (left)	1.0	2.6	6.1	0.3	1.3	2.5
Frequency of depressed mood in last 2 weeks	1.0	1.3	2.5	-1.6	-0.1	-1.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.4	1.0	1.6	0.6
Angina	1.0	1.3	2.1	1.1	1.5	0.7
Medication: Co-codamol	1.0	1.2	3.5	0.1	-1.9	-0.3
Medication: Simvastatin	1.0	1.5	3.9	-0.6	-0.5	-2.0
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.4	1.5	-1.8	-0.2
Age at last live birth	1.0	1.5	2.7	-1.6	0.0	-1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.4	1.8	0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.3	1.8	-0.6	1.0
Medication: Gliclazide	1.0	1.1	1.8	0.1	-1.3	-1.4
Miserableness	1.0	1.7	2.7	1.0	1.6	1.2
Ever had prostate specific antigen (PSA) test	1.0	1.2	1.7	0.5	1.3	1.3
Diastolic blood pressure, automated reading	1.0	3.2	6.9	-0.7	2.6	1.5
Intelligence (Savage-Jansen 2018)	0.9	2.9	7.4	-2.7	-0.0	-1.1
Hypothyroidism (self reported)	0.9	2.0	3.2	1.7	-1.8	-0.2
Average weekly spirits intake	0.9	1.1	2.4	1.5	-0.5	-0.8
Hearing difficulty/problems with background noise	0.9	1.5	4.2	-0.3	-0.2	-2.1
Weight	0.9	4.2	8.2	-1.5	2.9	1.5
Comparative body size at age 10	0.9	2.4	6.9	-2.6	0.6	-0.2
Medication for pain relief, constipation, heartburn	0.9	1.5	1.8	-1.4	-0.9	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.5	1.2	-0.9	0.9
Qualifications: nursing, teaching	0.9	1.4	2.3	-0.6	1.3	1.5
Back pain experienced in last month	0.9	1.3	1.4	1.0	1.2	1.2
Guilty feelings	0.9	1.4	2.0	-0.9	-1.4	-1.2
Ever smoked	0.9	1.5	3.6	-0.7	1.9	0.7
Fasting Glucose	0.8	1.0	1.5	1.2	0.5	1.1
Hearing difficulty/problems: Yes	0.8	1.3	1.9	1.4	1.4	0.1
Relative age of first facial hair	0.8	1.6	2.5	-1.2	-1.6	-1.0
Medication for hormone replacement therapy	0.8	0.9	1.2	1.1	0.6	1.0
Maternal smoking around birth	0.8	1.1	2.2	0.8	0.7	1.5
Stomach or abdominal pain in last month	0.8	1.0	2.4	-0.7	1.5	0.5
Medication: Levothyroxine sodium	0.8	1.3	2.5	0.8	-1.6	-0.9
Arm fat percentage (right)	0.8	3.1	4.7	-2.2	-1.3	-1.7
Pulse rate	0.8	1.4	3.0	0.3	1.7	1.0
Asthma	0.8	1.6	4.2	-0.2	-0.8	-2.0
Depression (self-reported)	0.8	1.0	1.7	0.6	-1.3	-1.0
Pulse wave Arterial Stiffness index	0.8	0.9	2.5	-0.1	1.6	0.5
Birth weight of first child	0.8	1.5	3.9	-0.4	-2.0	-0.7
Blood clot in the leg (DVT)	0.8	1.0	1.7	-0.9	0.8	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.5	0.3	0.6	1.6
Angina (self-reported)	0.8	1.1	2.2	0.8	1.5	0.7
Fractured/broken bones in last 5 years	0.8	1.0	2.0	1.4	-0.8	-0.5
Supplements: Calcium	0.8	0.9	2.3	-0.3	-0.5	-1.5
Alcohol drinker status: Previous	0.8	0.9	1.3	0.7	1.1	0.9
HbA1C	0.7	0.7	1.9	1.4	-0.1	0.6
Supplements: Zinc	0.7	0.8	1.0	-0.8	-1.0	-0.8
Pack years adult smoking proportion	0.7	1.1	1.7	0.7	1.3	1.1
Qualifications: CSEs or equivalent	0.7	0.9	1.1	1.1	0.6	1.0
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.9	0.7	-1.1	-1.7
Number of incorrect matches in round	0.7	1.2	2.0	-0.2	-1.4	-1.2
Hip circumference	0.7	2.9	5.7	-2.4	1.7	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.5	0.0	1.9	-0.1
Noisy workplace	0.7	0.8	1.9	1.4	0.0	0.7
Loud music exposure frequency	0.7	0.8	2.1	-1.4	-0.6	0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.4	0.1	0.4	1.9
Health satisfaction	0.7	0.9	2.4	-1.5	-0.1	-0.4
Qualifications: College or University degree	0.7	2.3	4.7	-2.2	0.6	-1.3
Medication: Allopurinol	0.7	0.9	2.2	1.5	0.5	0.6
Mean time to correctly identify matches	0.7	1.3	1.9	0.4	-1.3	-1.4
Chest pain or discomfort	0.7	1.0	2.7	1.6	0.1	0.5
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.0	-1.4	-0.8	-0.2
Eye problems/disorders: Cataract	0.7	0.9	1.6	0.8	1.2	0.6
Mineral and other dietary supplements	0.7	1.0	2.7	0.1	0.5	1.6
Asthma (self-reported)	0.7	1.5	3.7	-0.1	-0.8	-1.9
Financial situation satisfaction	0.7	0.9	1.4	-1.2	-0.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.3	0.0	-1.5	-0.5
Depression (Nagel 2018)	0.6	0.8	1.6	-1.3	0.2	-0.9
Crohns Disease (2017)	0.6	1.4	3.4	-1.8	-0.3	-0.9
Body Mass Index (BMI) (2010)	0.6	0.8	1.6	-1.3	0.1	0.8
Rheumatoid Arthritis	0.6	0.9	0.9	-1.0	-0.9	-0.9
Systolic Blood Pressure	0.6	3.0	6.4	0.3	2.5	1.6
Taking other prescription medications	0.6	0.9	2.3	0.1	-0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.3	1.2	0.3	1.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	-1.1	-0.5	-0.7
Supplements: Glucosamine	0.6	0.8	1.6	-0.1	-0.9	-1.3
Financial difficulties in last 2 years	0.6	0.9	1.9	0.2	-1.4	-0.8
Pulse wave reflection index	0.6	0.8	2.0	0.4	1.4	0.4
Pulse wave peak to peak time	0.6	0.7	1.9	-0.0	-1.4	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-0.0	-0.7	-1.3
Family relationship satisfaction	0.6	0.7	2.0	-0.1	-0.4	-1.4
Medication for cholesterol	0.6	0.9	1.6	-0.3	-1.3	-1.0
Number of self-reported non-cancer illnesses	0.6	1.1	2.7	1.6	0.6	0.4
Mother’s age at death	0.6	0.8	2.2	0.4	-1.5	-0.2
Unable to work because of sickness or disability	0.6	0.8	1.7	-0.5	-0.7	-1.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.2	1.0	0.4	-1.1
Pack years of smoking	0.6	0.9	1.1	0.8	1.0	0.9
Alzheimer’s Disease (in mother)	0.5	0.6	0.9	0.1	1.0	0.9
Cardiovascular Disease	0.5	1.5	3.2	-1.2	1.8	-0.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.9	0.3	-1.0	-0.9
Chronic bronchitis/emphysema (father)	0.5	0.6	1.5	1.2	-0.5	-0.3
Trunk fat mass	0.5	2.3	5.2	-2.3	-0.3	-1.3
Past tobacco smoking	0.5	0.9	1.8	0.7	-1.3	-0.6
Heart attack	0.5	0.7	1.3	0.8	0.1	-1.1
Father’s age at death	0.5	0.7	1.0	-0.4	-0.9	-1.0
Worrier / anxious feelings	0.5	0.9	2.0	-0.4	-0.7	-1.4
Lung cancer (father)	0.5	0.5	1.4	-1.2	-0.4	0.1
Medication: Amlodipine	0.5	0.8	1.2	0.9	-0.6	1.1
High blood pressure (siblings)	0.5	0.8	1.7	-0.7	1.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.0	1.0	0.9	0.3
Whole body fat mass	0.5	2.1	5.1	-2.3	-0.1	-1.1
Overall health rating	0.5	1.1	1.8	-1.4	-0.6	-1.1
Loneliness, isolation	0.5	0.7	1.6	-1.3	0.8	-0.1
Commuting to job workplace: Public transport	0.5	0.6	1.4	-1.2	0.3	-0.5
Heart disease (siblings)	0.5	0.6	1.1	1.0	-0.7	0.2
Irritable Bowel Disease (IBD)	0.4	0.8	2.4	-1.6	-0.2	0.2
Primary Biliary Cirrhosis	0.4	0.5	1.3	0.3	1.1	0.5
Ulcerative Colitis	0.4	0.5	0.5	-0.7	-0.7	-0.7
Blood Platelet Count	0.4	4.2	10.3	-3.2	1.3	-0.8
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	-0.7	-0.2	-0.9
Average weekly fortified wine intake	0.4	0.5	0.8	0.9	0.7	0.4
Fed-up feelings	0.4	0.7	1.1	-1.1	-1.0	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.7	-0.8	-0.5	-0.8
Multivitamins +/- minerals	0.4	0.5	1.0	-0.8	-1.0	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	0.9	0.6	0.6
High blood pressure (mother)	0.4	0.6	1.3	-1.1	0.7	-0.1
Waist circumference	0.4	1.5	3.5	-1.9	0.9	-0.3
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	0.9	-0.1	-0.8
Qualifications: None of the above	0.4	0.8	1.0	0.9	-1.0	-0.7
Pain all over the body in last month	0.4	0.5	0.8	0.6	-0.9	-0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	1.1	-0.0	-0.4
Exposure to tobacco smoke at home	0.4	0.4	1.0	-0.4	-1.0	-0.2
Gout (self-reported)	0.4	0.6	1.4	1.2	-0.5	-0.3
Birth weight	0.4	0.9	1.4	-0.7	1.2	0.9
Exposure to tobacco smoke outside home	0.4	0.5	0.9	-0.9	-0.7	-0.4
Wheeze or whistling in the chest in last year	0.4	0.8	1.8	1.3	0.7	0.2
Heart disease (mother)	0.4	0.4	0.8	-0.0	0.7	-0.9
Leg fat mass (right)	0.4	1.7	4.6	-2.1	0.2	-0.8
Number of full sisters	0.4	0.4	0.5	-0.7	0.6	0.7
Supplements: Vitamin C	0.4	0.5	0.7	0.8	-0.8	-0.5
Long-standing illness, disability or infirmity	0.4	0.5	0.9	-0.6	-0.6	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	0.5	0.6	0.9
Medication: Blood pressure	0.4	0.7	1.8	-0.4	1.3	-0.3
Medication: Paracetamol	0.4	0.6	1.6	1.3	0.1	-0.5
Number of operations (self-reported)	0.4	0.6	0.8	0.5	-0.8	-0.9
Bipolar Disorder (2018)	0.3	0.4	0.8	-0.5	0.9	0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	0.0	0.8	0.7
Alzheimer’s Disease (in father)	0.3	0.4	0.6	0.8	-0.7	-0.2
Ulcerative Colitis (UC)	0.3	0.6	1.3	-0.6	0.2	1.1
Prostate Cancer	0.3	0.4	1.0	-1.0	-0.4	0.2
Crohns Disease (2012)	0.3	0.6	1.3	-1.1	0.1	-0.6
Lupus	0.3	0.5	1.4	0.2	-0.3	1.2
Neuroticism (2016)	0.3	0.5	0.8	-0.2	-0.9	-0.7
Blood Eosinophil Count	0.3	2.3	5.8	-0.9	-0.6	-2.4
BMI	0.3	1.7	3.0	-1.7	1.1	0.9
Number of treatments/medications taken	0.3	0.5	0.6	0.8	0.6	-0.7
Diabetes (mother)	0.3	0.4	1.1	0.4	1.0	-0.0
Serious illness, injury or assault to yourself	0.3	0.4	0.8	0.6	0.9	0.0
Nervous feelings	0.3	0.6	0.9	-0.8	-0.4	-1.0
Falls in the last year	0.3	0.5	0.9	0.9	-0.6	-0.4
Happiness	0.3	0.4	0.6	-0.2	0.7	0.8
Arm fat mass (right)	0.3	1.2	2.9	-1.7	0.8	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.6	-0.1	-0.9
Medication: Paracetamol	0.3	0.5	1.4	1.2	-0.2	-0.3
Emphysema/chronic bronchitis	0.3	0.4	0.9	-0.4	-0.3	-0.9
Medication: Seretide 50 evohaler	0.3	0.4	0.6	-0.8	-0.3	-0.6
Illnesses of father: Heart disease	0.3	0.3	0.6	-0.2	0.8	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.9	0.4	1.0	-0.1
Friendships satisfaction	0.3	0.4	0.5	-0.7	-0.6	-0.6
Arm fat mass (left)	0.3	1.1	2.5	-1.6	0.9	0.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.7	0.2	-0.6
Alcohol drinker status: Never	0.3	0.4	0.6	0.4	0.8	0.7
Average weekly beer plus cider intake	0.3	0.5	1.2	-0.1	-0.4	1.1
Risk taking	0.3	0.5	0.8	0.9	-0.7	-0.1
Age started oral contraceptive pill	0.3	0.4	1.2	0.0	0.2	-1.1
Leg fat mass (left)	0.3	1.3	3.4	-1.8	0.3	-0.5
Mean Putamen Volume	0.2	0.3	0.6	0.8	-0.3	0.3
HDL Cholesterol	0.2	0.4	0.8	0.5	-0.9	0.1
Schizophrenia (2014)	0.2	0.4	0.8	0.5	0.1	0.9
Blood Red Count	0.2	1.5	3.1	-1.8	0.5	-1.1
Blood White Count	0.2	1.7	4.1	-2.0	0.8	-0.6
Lung FVC	0.2	0.8	1.7	0.4	1.3	0.7
Chronotype (morning person)	0.2	0.5	0.9	-0.7	-1.0	-0.4
Hair Pigment	0.2	5.3	9.3	1.0	3.0	2.4
High blood pressure	0.2	0.6	0.7	-0.8	0.8	-0.6
Time employed in main current job	0.2	0.2	0.5	0.1	-0.7	-0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.2	-0.5	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.7	0.1	0.6
Number of live births	0.2	0.3	0.6	0.8	0.2	-0.4
Age at first live birth	0.2	0.4	0.7	-0.6	0.8	-0.4
Shortness of breath walking on level ground	0.2	0.2	0.3	-0.4	0.5	0.5
Neck or shoulder pain in last month	0.2	0.3	0.5	0.7	0.5	0.4
Medication: Blood pressure	0.2	0.3	0.7	0.4	-0.5	-0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.4	0.5	0.6
Hypertension (Self-reported)	0.2	0.6	1.0	-1.0	0.5	-0.8
Smoking status: Previous	0.2	0.3	0.4	-0.6	-0.1	-0.6
Breast cancer (self-reported)	0.2	0.2	0.4	-0.1	0.6	0.6
Osteoporosis (self-reported)	0.2	0.2	0.6	0.4	-0.7	-0.0
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.4	-0.3	-0.6
Medication: Lisinopril	0.2	0.3	0.6	-0.8	0.0	-0.5
Medication: Atorvastatin	0.2	0.2	0.3	0.5	-0.1	-0.5
Pain experienced in last month	0.2	0.3	0.5	0.2	-0.7	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	0.1	0.6	0.7
Schizophrenia (2018)	0.1	0.1	0.3	0.4	-0.0	0.5
Reaction Time	0.1	0.2	0.5	0.7	-0.3	-0.3
Heel T-Score	0.1	0.5	1.2	-0.5	-1.1	-0.2
Lung FEV1/FVC ratio	0.1	0.5	0.9	0.0	-0.9	0.8
Tanning	0.1	1.2	1.7	0.9	-1.3	-1.1
Systolic blood pressure, automated reading	0.1	0.3	0.7	-0.5	0.8	0.1
Severe depression (siblings)	0.1	0.1	0.2	0.2	-0.2	-0.5
Age when periods started (menarche)	0.1	0.3	0.6	0.8	-0.5	-0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.2	-0.4	-0.3
Body mass index (BMI)	0.1	0.5	1.0	-1.0	0.7	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.2	0.6	0.1
Illnesses of siblings	0.1	0.1	0.3	-0.0	-0.6	0.2
Breastfed as a baby	0.1	0.2	0.4	-0.4	-0.0	-0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.1	-0.6	0.0
Glaucoma (self-reported)	0.1	0.1	0.4	-0.1	0.6	0.2
Number of children fathered	0.1	0.2	0.3	0.4	0.3	0.5
Eye problems/disorders: None of the above	0.1	0.2	0.3	0.1	-0.5	0.5
Medication: Omeprazole	0.1	0.1	0.2	0.2	-0.4	0.2
Pulse rate, automated reading	0.1	0.2	0.5	0.7	-0.0	-0.3
Knee pain experienced in last month	0.1	0.1	0.4	-0.1	-0.7	-0.0
Osteoarthritis (self-reported)	0.1	0.2	0.3	-0.4	-0.2	0.5
Medication: Aspirin	0.1	0.2	0.4	-0.1	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	0.5	0.6	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.6	0.1	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.4	0.0	-0.7
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.3	0.4	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.5	0.4	-0.7	0.7
Cholesterol lowering medication	0.1	0.2	0.3	-0.3	0.6	-0.4
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	0.3	-0.0	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Waist Hip Ratio (WHR)	0.0	0.1	0.2	0.4	-0.2	0.2
Townsend deprivation index at recruitment	0.0	0.0	0.0	0.1	-0.2	-0.1
Medication: Aspirin	0.0	0.1	0.2	0.1	0.0	-0.4
Ever depressed for a whole week	0.0	0.0	0.1	0.2	0.1	-0.3

Hub : Genes

TBC1D17

Models

Trait associations