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chr3:8,123,440-11,059,996

Best TWAS P=6.59e-23 · Best GWAS P=8.37e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CRELD1	0.46	0.16	enet	51	0.27	2.2e-22	-7.2	-9.8	6.6e-23	0.76	0.00	1.00	TRUE
2	GTEx	Adipose Visceral Omentum	CRELD1	0.19	0.12	lasso	4	0.10	4.1e-06	-7.2	-7.9	3.4e-15	0.91	0.00	1.00	TRUE
9	GTEx	Breast Mammary Tissue	CRELD1	0.25	0.19	lasso	6	0.18	2.2e-09	-7.2	-7.2	7.7e-13	1.00	0.00	1.00	TRUE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CRELD1	0.03	0.00	blup	49	0.01	1.4e-02	-4.5	-6.8	7.9e-12	0.35	0.01	0.11	TRUE
17	GTEx	Testis	CRELD1	0.22	0.22	lasso	8	0.26	1.1e-11	4.2	-6.5	6.0e-11	0.67	0.12	0.88	TRUE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL17RC	0.07	0.05	blup	52	0.06	7.7e-06	-4.3	6.2	5.2e-10	-0.28	0.84	0.03	TRUE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC401052	0.06	0.07	enet	6	0.06	3.5e-07	6.1	-5.8	5.5e-09	0.23	0.01	0.99	TRUE
19	METSIM	Adipose	RAD18	0.07	0.00	blup	809	0.01	2.9e-03	-4.4	-5.7	1.2e-08	0.00	0.01	0.97	TRUE
10	GTEx	Cells Transformed fibroblasts	CRELD1	0.39	0.19	enet	39	0.28	4.5e-21	-7.2	-9.4	4.2e-21	0.79	0.00	1.00	FALSE
16	GTEx	Skin Sun Exposed Lower leg	CRELD1	0.29	0.15	enet	36	0.23	8.2e-19	-7.2	-9.4	7.2e-21	0.75	0.00	1.00	FALSE
11	GTEx	Cells Transformed fibroblasts	RP11-1020A11.1	0.20	0.10	enet	67	0.09	1.9e-07	-7.2	-9.1	6.1e-20	0.66	0.00	1.00	FALSE
7	GTEx	Artery Tibial	CRELD1	0.43	0.15	enet	41	0.21	1.1e-16	-7.2	-8.3	1.3e-16	0.78	0.00	1.00	FALSE
5	GTEx	Artery Aorta	RP11-1020A11.1	0.15	0.01	lasso	3	0.00	4.0e-01	-7.2	-8.2	2.2e-16	0.91	0.01	0.83	FALSE
4	GTEx	Artery Aorta	CRELD1	0.30	0.07	lasso	7	0.12	2.4e-07	-7.2	-8.2	3.7e-16	0.88	0.00	1.00	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	CRELD1	0.29	0.07	enet	25	0.13	9.7e-08	-3.0	-8.0	1.1e-15	0.44	0.02	0.96	FALSE
18	METSIM	Adipose	CRELD1	0.23	0.16	bslmm	480	0.21	3.1e-30	-7.2	-7.9	2.7e-15	0.74	0.00	1.00	FALSE
14	GTEx	Nerve Tibial	CRELD1	0.17	0.05	enet	9	0.13	2.0e-09	-7.2	-7.5	8.1e-14	0.81	0.00	1.00	FALSE
13	GTEx	Esophagus Muscularis	CRELD1	0.21	0.10	lasso	1	0.08	1.7e-05	-7.2	-7.2	8.4e-13	1.00	0.00	1.00	FALSE
12	GTEx	Esophagus Mucosa	CRELD1	0.14	0.06	enet	7	0.11	7.7e-08	-7.2	-7.0	2.2e-12	0.81	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	JAGN1	0.04	0.04	blup	49	0.03	2.6e-04	-4.5	-6.7	2.2e-11	0.31	0.58	0.08	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	IL17RC	0.03	0.02	blup	53	0.02	8.1e-04	-2.5	6.4	1.6e-10	-0.34	0.16	0.04	FALSE
32	The Cancer Genome Atlas	Soft Tissue Sarcoma	CRELD1	0.12	0.01	enet	22	0.04	1.4e-03	-4.1	-6.3	2.5e-10	0.39	0.02	0.19	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	JAGN1	0.03	0.00	blup	49	0.02	2.1e-03	-4.1	-6.3	3.1e-10	0.29	0.06	0.13	FALSE
22	YFS	Blood	PRRT3	0.08	0.02	bslmm	469	0.04	7.4e-13	-7.2	-6.1	9.1e-10	0.51	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CRELD1	0.05	0.00	enet	9	0.03	3.5e-04	-4.5	-5.8	4.8e-09	0.39	0.08	0.09	FALSE
21	YFS	Blood	FANCD2	0.04	0.04	lasso	1	0.04	7.7e-13	5.8	-5.8	6.2e-09	0.22	0.80	0.20	FALSE
6	GTEx	Artery Tibial	RAD18	0.13	0.11	lasso	3	0.09	8.7e-08	-5.5	-5.6	1.9e-08	0.04	0.01	0.99	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	SEC13	0.06	0.01	bslmm	606	0.02	1.0e-03	2.6	5.5	3.8e-08	-0.31	0.60	0.03	FALSE
3	GTEx	Artery Aorta	RAD18	0.24	0.04	lasso	5	0.05	1.6e-03	4.0	-5.5	4.4e-08	-0.05	0.11	0.66	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	JAGN1	0.02	0.00	blup	49	0.01	2.1e-03	-2.5	-5.4	6.2e-08	0.27	0.05	0.04	FALSE
8	GTEx	Brain Cerebellum	IL17RC	0.55	0.46	lasso	6	0.50	9.0e-17	-4.6	-5.4	7.5e-08	0.29	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	JAGN1	0.03	0.03	blup	48	0.02	4.2e-03	-4.6	-5.3	1.3e-07	0.26	0.42	0.07	FALSE