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chr3:11,829,474-14,912,402

Best TWAS P=1.38e-16 · Best GWAS P=1.67e-23 conditioned to 6.46e-17

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TMEM43	0.10	0.01	blup	568	0.03	8.4e-05	-5.0	8.3	1.4e-16	-0.01	0.58	0.01	TRUE
10	GTEx	Heart Atrial Appendage	MKRN2	0.14	0.09	lasso	3	0.08	1.5e-04	-7.3	-7.9	3.3e-15	-0.06	0.01	0.99	TRUE
2	CommonMind	Brain Pre-frontal Cortex	WNT7A	0.07	0.01	bslmm	539	0.03	1.3e-04	-6.4	-5.9	4.2e-09	-0.17	0.34	0.02	TRUE
20	The Cancer Genome Atlas	Esophageal Carcinoma	XPC	0.20	0.07	lasso	5	0.06	4.6e-03	-6.8	5.7	1.6e-08	0.06	0.00	0.95	TRUE
18	YFS	Blood	RAF1	0.02	0.03	lasso	2	0.03	2.1e-10	-7.6	-7.7	1.1e-14	-0.07	0.01	0.99	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	MKRN2	0.17	0.10	enet	13	0.07	1.9e-03	-8.0	-7.6	2.7e-14	-0.09	0.01	0.97	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	MKRN2	0.32	0.26	lasso	4	0.21	1.5e-07	-6.6	6.6	4.9e-11	0.05	0.74	0.21	FALSE
11	GTEx	Heart Left Ventricle	MKRN2	0.21	0.05	enet	15	0.14	1.1e-07	-7.2	-6.5	6.4e-11	-0.12	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RAF1	0.31	0.16	lasso	4	0.16	3.8e-06	6.7	6.4	1.4e-10	0.09	0.26	0.54	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	TSEN2	0.15	0.11	lasso	8	0.13	1.1e-16	-6.8	6.3	2.5e-10	0.08	0.94	0.06	FALSE
6	GTEx	Artery Tibial	TSEN2	0.14	0.10	lasso	6	0.07	5.3e-06	-6.4	6.3	3.5e-10	0.08	0.16	0.84	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	XPC	0.10	0.04	lasso	4	0.05	2.8e-07	4.8	-6.1	1.1e-09	-0.13	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	MKRN2	0.20	0.05	enet	11	0.09	1.7e-05	-7.2	-6.0	2.5e-09	-0.12	0.03	0.96	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	WNT7A	0.12	0.04	enet	8	0.05	6.6e-07	-6.4	-6.0	2.7e-09	-0.14	0.99	0.00	FALSE
14	GTEx	Thyroid	MKRN2	0.11	0.04	enet	14	0.05	6.3e-05	-7.5	-5.8	7.3e-09	-0.12	0.02	0.97	FALSE
9	GTEx	Esophagus Muscularis	MKRN2	0.15	0.05	lasso	8	0.12	8.9e-08	6.4	-5.6	2.0e-08	-0.13	0.25	0.74	FALSE
3	GTEx	Adipose Subcutaneous	RAF1	0.08	0.02	lasso	6	0.04	5.2e-04	-5.7	5.4	6.5e-08	-0.02	0.76	0.03	FALSE
13	GTEx	Nerve Tibial	CAND2	0.12	0.01	enet	8	0.03	4.9e-03	4.9	5.3	9.5e-08	-0.01	0.30	0.06	FALSE
5	GTEx	Artery Tibial	MKRN2	0.27	0.09	enet	20	0.25	3.1e-19	-1.2	-5.3	1.3e-07	-0.15	0.05	0.95	FALSE
12	GTEx	Muscle Skeletal	CAND2	0.34	0.29	lasso	5	0.31	1.0e-30	5.0	-5.2	1.9e-07	-0.01	1.00	0.00	FALSE
19	YFS	Blood	TMEM43	0.05	0.01	lasso	6	0.02	7.6e-07	-2.3	5.2	1.9e-07	0.00	0.69	0.30	FALSE