Best TWAS P=1.38e-16 · Best GWAS P=1.67e-23 conditioned to 6.46e-17
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TMEM43 | 0.10 | 0.01 | blup | 568 | 0.03 | 8.4e-05 | -5.0 | 8.3 | 1.4e-16 | -0.01 | 0.58 | 0.01 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | WNT7A | 0.07 | 0.01 | bslmm | 539 | 0.03 | 1.3e-04 | -6.4 | -5.9 | 4.2e-09 | -0.17 | 0.34 | 0.02 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | RAF1 | 0.08 | 0.02 | lasso | 6 | 0.04 | 5.2e-04 | -5.7 | 5.4 | 6.5e-08 | -0.02 | 0.76 | 0.03 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | MKRN2 | 0.20 | 0.05 | enet | 11 | 0.09 | 1.7e-05 | -7.2 | -6.0 | 2.5e-09 | -0.12 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Artery Tibial | MKRN2 | 0.27 | 0.09 | enet | 20 | 0.25 | 3.1e-19 | -1.2 | -5.3 | 1.3e-07 | -0.15 | 0.05 | 0.95 | FALSE |
| 6 | GTEx | Artery Tibial | TSEN2 | 0.14 | 0.10 | lasso | 6 | 0.07 | 5.3e-06 | -6.4 | 6.3 | 3.5e-10 | 0.08 | 0.16 | 0.84 | FALSE |
| 7 | GTEx | Cells EBV-transformed lymphocytes | MKRN2 | 0.32 | 0.26 | lasso | 4 | 0.21 | 1.5e-07 | -6.6 | 6.6 | 4.9e-11 | 0.05 | 0.74 | 0.21 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | MKRN2 | 0.17 | 0.10 | enet | 13 | 0.07 | 1.9e-03 | -8.0 | -7.6 | 2.7e-14 | -0.09 | 0.01 | 0.97 | FALSE |
| 9 | GTEx | Esophagus Muscularis | MKRN2 | 0.15 | 0.05 | lasso | 8 | 0.12 | 8.9e-08 | 6.4 | -5.6 | 2.0e-08 | -0.13 | 0.25 | 0.74 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | MKRN2 | 0.14 | 0.09 | lasso | 3 | 0.08 | 1.5e-04 | -7.3 | -7.9 | 3.3e-15 | -0.06 | 0.01 | 0.99 | TRUE |
| 11 | GTEx | Heart Left Ventricle | MKRN2 | 0.21 | 0.05 | enet | 15 | 0.14 | 1.1e-07 | -7.2 | -6.5 | 6.4e-11 | -0.12 | 0.02 | 0.98 | FALSE |
| 12 | GTEx | Muscle Skeletal | CAND2 | 0.34 | 0.29 | lasso | 5 | 0.31 | 1.0e-30 | 5.0 | -5.2 | 1.9e-07 | -0.01 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Nerve Tibial | CAND2 | 0.12 | 0.01 | enet | 8 | 0.03 | 4.9e-03 | 4.9 | 5.3 | 9.5e-08 | -0.01 | 0.30 | 0.06 | FALSE |
| 14 | GTEx | Thyroid | MKRN2 | 0.11 | 0.04 | enet | 14 | 0.05 | 6.3e-05 | -7.5 | -5.8 | 7.3e-09 | -0.12 | 0.02 | 0.97 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | TSEN2 | 0.15 | 0.11 | lasso | 8 | 0.13 | 1.1e-16 | -6.8 | 6.3 | 2.5e-10 | 0.08 | 0.94 | 0.06 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | WNT7A | 0.12 | 0.04 | enet | 8 | 0.05 | 6.6e-07 | -6.4 | -6.0 | 2.7e-09 | -0.14 | 0.99 | 0.00 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | XPC | 0.10 | 0.04 | lasso | 4 | 0.05 | 2.8e-07 | 4.8 | -6.1 | 1.1e-09 | -0.13 | 1.00 | 0.00 | FALSE |
| 18 | YFS | Blood | RAF1 | 0.02 | 0.03 | lasso | 2 | 0.03 | 2.1e-10 | -7.6 | -7.7 | 1.1e-14 | -0.07 | 0.01 | 0.99 | FALSE |
| 19 | YFS | Blood | TMEM43 | 0.05 | 0.01 | lasso | 6 | 0.02 | 7.6e-07 | -2.3 | 5.2 | 1.9e-07 | 0.00 | 0.69 | 0.30 | FALSE |
| 20 | The Cancer Genome Atlas | Esophageal Carcinoma | XPC | 0.20 | 0.07 | lasso | 5 | 0.06 | 4.6e-03 | -6.8 | 5.7 | 1.6e-08 | 0.06 | 0.00 | 0.95 | TRUE |
| 21 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RAF1 | 0.31 | 0.16 | lasso | 4 | 0.16 | 3.8e-06 | 6.7 | 6.4 | 1.4e-10 | 0.09 | 0.26 | 0.54 | FALSE |