Hub : Genes

RAD18

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2440	0.0750	1.9e-03	0.038	NA	0.010	NA	0.045	3.7e-03	NA	9.2e-02	NA	1.6e-03
2	GTEx	Artery Tibial	0.1317	0.0424	3.6e-04	0.108	NA	0.069	NA	0.094	9.0e-09	NA	4.1e-06	NA	8.7e-08
3	GTEx	Cells Transformed fibroblasts	0.2360	0.0580	6.2e-05	0.119	NA	0.085	NA	0.105	3.1e-09	NA	6.2e-07	NA	2.7e-08
4	METSIM	Adipose	0.0735	0.0278	2.0e-03	0.001	0.014	0.007	0.014	0.004	2.4e-01	2.9e-03	2.4e-02	3.3e-03	8.3e-02
5	ROSMAP	Brain Pre-frontal Cortex	0.0845	0.0233	4.4e-07	0.037	0.057	0.055	0.058	0.053	1.3e-05	7.0e-08	1.2e-07	5.9e-08	2.1e-07
6	TCGA	Pancreatic Adenocarcinoma	0.2070	0.0950	6.8e-03	0.000	0.018	-0.002	NA	0.001	3.1e-01	5.9e-02	3.9e-01	NA	3.0e-01
7	TCGA	Thyroid Carcinoma	0.1060	0.0400	8.5e-06	0.075	0.063	0.065	NA	0.072	9.1e-08	9.8e-07	5.9e-07	NA	1.7e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.8	1.7	1.2	1.2	0.5	1.3	-0.6	-0.1	0.6
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	1.4	0.3	0.5	1.6	-1.2	-0.2	0.9
Depressed Affect (Nagel 2018)	0.7	1.5	2.9	1.6	0.9	1.0	1.4	-0.2	1.7	1.1
Depression (Nagel 2018)	1.1	1.7	3.1	1.8	0.9	1.5	1.1	0.0	1.4	1.5
Intelligence (Savage-Jansen 2018)	0.7	2.3	6.5	-1.6	0.9	-1.5	-0.5	-2.5	-1.0	-1.6
Neuroticism (Nagel 2018)	0.3	0.8	1.7	1.3	0.8	0.8	1.2	-0.1	1.0	0.6
Schizophrenia (2018)	0.2	0.5	1.1	0.8	-0.5	0.3	0.9	-1.0	-0.1	0.7
Schizophrenia vs Biploar Disorder	1.4	1.9	6.7	-0.8	-2.6	-0.2	-2.0	1.4	0.0	-0.1
Worry (Nagel 2018)	0.2	0.4	1.0	1.0	0.6	0.5	0.7	0.1	0.5	0.3
Alzheimer’s Disease (in mother)	0.3	0.4	1.4	0.5	0.7	0.3	1.2	0.1	-0.4	0.4
Alzheimer’s Disease (in father)	0.3	0.4	1.3	0.5	0.8	0.0	1.1	-0.7	0.2	0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	3.6	0.6	1.3	0.1	1.9	-0.9	0.0	0.3
Crohns Disease (2017)	0.4	0.9	4.4	0.3	-1.2	0.1	0.1	2.1	0.2	0.4
Irritable Bowel Disease (IBD)	0.2	0.4	1.3	0.5	-0.1	0.1	0.7	1.1	0.6	0.5
Ulcerative Colitis (UC)	0.2	0.4	0.8	0.7	0.8	0.3	0.9	-0.0	0.7	0.6
Major Depression (MDD)	0.3	0.4	1.8	0.5	0.4	0.5	1.3	0.1	-0.5	0.5
Reaction Time	1.1	2.1	3.4	-1.8	-1.9	-1.3	-1.2	0.5	-1.5	-1.5
Verbal and Numeric Reasoning (VNR)	1.9	4.6	8.4	-2.9	0.2	-2.4	-1.0	-2.6	-2.1	-2.5
Breast Cancer	0.4	0.9	1.7	0.9	1.0	1.1	1.3	0.6	0.7	0.9
Ovarian Cancer	1.6	2.1	4.0	-1.9	0.6	-1.7	0.2	-1.6	-1.2	-2.0
Prostate Cancer	1.2	1.7	2.9	-0.9	0.9	-1.7	0.5	-1.7	-1.3	-1.6
Age at First Birth	0.7	1.0	3.0	-1.4	-1.7	-0.7	-0.6	0.1	-0.9	-0.8
Bipolar Disorder (2011)	1.5	1.4	5.0	-1.0	-1.0	-1.2	0.6	0.3	-2.2	-1.1
Body Mass Index (BMI) (2010)	0.8	1.0	3.1	1.0	1.8	0.5	1.0	-0.6	1.0	0.7
Coronary Artery Disease (CAD)	0.6	0.7	2.8	0.6	1.0	0.4	1.7	-0.8	0.4	0.4
Crohns Disease (2012)	1.0	1.7	5.9	1.1	-0.5	1.0	-0.2	2.4	1.4	1.2
Mean Putamen Volume	0.5	0.5	2.1	0.5	-0.3	0.4	0.8	0.6	1.4	0.4
Fasting Glucose	0.8	1.0	4.2	0.9	0.8	0.8	0.1	-0.1	2.1	0.8
HbA1C	2.7	3.0	7.7	-2.0	-1.0	-2.1	-0.4	-0.3	-2.8	-1.9
HDL Cholesterol	0.1	0.2	0.3	0.2	0.6	-0.2	0.3	-0.4	0.6	-0.2
LDL Cholesterol	0.4	0.6	1.1	-0.9	0.2	-1.0	-0.3	-0.8	-0.4	-1.0
Lupus	0.6	0.9	2.2	0.9	0.2	1.1	1.1	0.4	1.5	1.0
Neuroticism (2016)	0.9	1.2	4.2	-0.2	-2.1	0.3	-1.4	1.2	-0.8	0.1
Primary Biliary Cirrhosis	1.2	1.8	3.4	-1.6	-0.4	-1.8	0.2	-0.8	-1.6	-1.8
Rheumatoid Arthritis	0.9	1.3	2.7	1.5	0.2	1.5	-0.4	0.7	1.0	1.6
Schizophrenia (2014)	0.2	0.4	0.8	0.8	-0.9	0.5	0.8	-0.2	0.0	0.8
Triglycerides	0.3	0.5	1.2	-0.3	0.8	-0.9	-0.0	-1.1	-0.1	-0.7
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.9	-1.4	-1.2	-1.3	-0.7	0.5	-0.2	-0.9
Ulcerative Colitis	0.4	0.6	1.4	0.7	0.5	0.9	-0.0	0.4	1.2	1.0
Blood Eosinophil Count	0.2	1.3	3.8	0.3	1.8	0.3	1.3	-2.0	-0.5	0.1
Blood Platelet Count	0.1	0.8	2.0	0.7	-1.1	0.7	0.5	1.4	0.6	0.7
Blood Red Count	0.9	8.5	14.4	3.5	-0.8	3.8	0.3	3.0	2.9	3.8
Blood White Count	0.3	2.1	4.0	0.4	-1.1	1.4	-1.9	2.0	1.5	1.3
Heel T-Score	0.1	0.7	2.4	-0.8	0.8	-0.5	-0.2	-1.6	-0.7	-0.6
BMI	0.6	3.7	9.2	1.2	3.0	1.3	1.0	-3.0	1.1	1.4
Height	2.1	40.3	63.0	-7.9	-6.5	-6.8	-5.9	1.4	-6.8	-6.8
Waist Hip Ratio (WHR)	0.1	0.4	1.3	-0.4	0.8	-0.1	1.1	-0.6	0.7	-0.2
Systolic Blood Pressure	0.1	0.5	1.1	0.9	0.9	0.4	0.2	-1.1	-0.3	0.4
Smoking Status	0.1	0.3	0.7	0.1	0.3	0.0	-0.8	-0.9	-0.7	0.0
Allergy or Eczema	0.8	2.0	3.6	-1.9	0.2	-1.7	-0.9	-1.3	-1.4	-1.8
Cardiovascular Disease	0.1	0.2	0.6	0.2	-0.2	0.8	-0.6	0.3	0.2	0.5
Hypothyroidism (self reported)	0.2	0.5	1.1	-0.8	-1.1	-0.5	0.4	0.7	-0.5	-0.5
Respiratory disease	1.4	3.0	6.4	1.3	2.3	1.2	2.5	-1.5	1.6	1.1
Type 2 Diabetes (T2D) (2018)	1.8	3.3	6.2	-2.3	0.8	-1.8	1.9	-2.5	-0.6	-2.0
Lung FEV1/FVC ratio	0.0	0.2	0.5	0.7	0.5	0.0	0.2	-0.6	-0.4	0.2
Lung FVC	3.8	19.5	31.1	4.6	-1.6	5.4	-2.1	5.3	4.5	5.6
Neuroticism	0.2	0.5	1.1	1.1	-0.1	0.8	0.3	0.8	0.6	0.7
Chronotype (morning person)	0.6	1.3	4.0	-0.8	1.2	-1.1	0.5	-2.0	-0.3	-1.2
Hair Pigment	0.0	0.5	2.3	-0.5	-0.3	0.7	-0.8	1.5	0.2	-0.2
Tanning	0.1	1.4	2.4	0.9	-1.5	1.4	-0.4	1.5	0.3	1.5
Hand grip strength (left)	1.0	2.7	8.8	-1.7	-1.8	-1.1	-3.0	0.9	-1.0	-0.9
Number of treatments/medications taken	0.4	0.7	1.4	0.7	1.0	0.9	0.6	-1.2	-0.1	0.8
Average weekly spirits intake	0.4	0.5	1.3	-0.9	-0.2	-1.1	-0.6	0.4	-0.0	-1.0
Sensitivity / hurt feelings	0.3	0.5	0.9	0.9	0.2	0.7	0.3	0.7	1.0	0.6
Frequency of depressed mood in last 2 weeks	1.5	2.2	4.8	1.6	0.7	1.8	0.3	0.9	2.2	1.8
Hearing difficulty/problems: Yes	0.2	0.4	1.1	-1.0	-0.7	-0.4	-0.4	0.8	0.2	-0.4
Relative age of first facial hair	0.4	0.8	2.2	-0.7	0.4	-0.9	-0.3	-1.0	-1.5	-1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.9	0.0	0.4	-0.1	0.6	-0.9	-0.5	0.0
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.8	-0.3	0.3	0.3	-0.3	-0.9	-0.3	0.0
Ever had hysterectomy (womb removed)	1.4	1.5	3.7	-1.0	-1.0	-1.2	-1.9	-0.0	-1.4	-1.4
Systolic blood pressure, automated reading	0.4	1.2	3.2	0.2	1.7	-0.3	1.3	-1.8	-0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.1	-1.8	-1.0	-1.6	0.1	-0.3	-0.6	-1.7
Angina	1.1	1.4	2.5	1.3	1.6	1.2	0.4	-1.3	1.2	1.0
Medication for hormone replacement therapy	0.5	0.6	3.2	-0.2	-0.7	0.2	-0.3	0.4	-1.8	0.2
Vitamin and mineral supplements	0.2	0.2	0.6	0.0	-0.4	0.2	-0.4	0.6	0.8	0.3
Supplements: Zinc	2.3	2.5	6.3	-1.6	-2.5	-1.1	-0.8	1.2	-1.8	-1.3
Medication: Co-codamol	1.7	1.9	4.0	1.8	0.6	1.8	0.7	0.8	1.1	2.0
Medication: Metformin	1.0	1.4	4.2	-0.6	1.6	-1.0	0.8	-2.0	-0.3	-1.0
Diabetes (father)	0.1	0.1	0.2	-0.4	0.3	-0.2	-0.0	-0.4	-0.0	-0.2
Diabetes (mother)	1.2	1.5	2.9	1.7	1.3	1.3	1.0	-0.1	1.1	1.4
Severe depression (siblings)	0.2	0.2	0.9	-0.4	-0.5	-0.1	-0.2	0.9	0.3	-0.2
Pack years adult smoking proportion	0.4	0.7	2.7	-0.2	-1.0	0.0	-1.0	1.6	-0.1	-0.0
Impedance of leg (right)	0.2	1.0	4.5	0.6	-0.2	0.0	2.1	1.4	0.2	0.1
Leg fat-free mass (left)	0.5	2.7	12.5	-1.7	-1.2	-0.7	-3.5	-0.7	-1.0	-0.6
Trunk fat percentage	1.0	3.9	7.4	1.9	2.7	1.4	2.1	-2.4	1.3	1.5
Hand grip strength (right)	0.7	1.9	5.6	-1.3	-1.9	-0.8	-2.4	0.5	-1.2	-0.7
Townsend deprivation index at recruitment	0.2	0.3	1.0	-0.8	-0.5	-0.2	-1.0	0.3	0.1	-0.4
Current tobacco smoking	0.7	1.1	2.6	-0.2	-1.6	0.3	-1.5	1.6	-0.7	0.3
Average weekly fortified wine intake	0.3	0.4	0.9	-0.5	-0.9	-0.4	0.7	0.8	-0.4	-0.4
Maternal smoking around birth	0.2	0.4	1.5	0.2	0.8	-0.1	0.5	-1.2	0.2	-0.0
Fed-up feelings	1.6	2.8	5.1	1.8	-0.6	1.9	-0.3	2.3	2.0	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	0.8	1.0	0.4	0.4	-0.3	1.1	0.5
Relative age voice broke	0.4	0.6	1.5	1.0	1.2	0.4	1.0	-0.5	0.1	0.4
Taking other prescription medications	0.1	0.2	0.3	-0.1	0.5	0.4	0.3	-0.6	0.4	0.3
Age when periods started (menarche)	0.7	1.8	3.6	-1.8	-1.9	-1.2	-0.2	0.7	-1.3	-1.3
Bilateral oophorectomy (both ovaries removed)	5.7	6.6	8.9	-2.7	-3.0	-2.3	-2.8	1.4	-3.0	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.1	0.6	-0.5	0.9	-0.4	0.9	-0.4	1.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.6	-0.2	-0.8	-0.2	-0.6	1.3	-0.4	-0.3
Qualifications: CSEs or equivalent	0.9	1.1	1.7	1.1	-0.6	1.3	-0.6	1.1	1.2	1.3
Serious illness, injury or assault to yourself	0.5	0.6	1.5	-0.3	1.0	-0.8	0.8	-1.2	0.1	-0.6
High blood pressure	0.1	0.2	1.1	-0.6	-0.5	0.1	-1.1	-0.0	0.0	-0.0
Hayfever, allergic rhinitis or eczema	0.4	1.0	1.8	-1.4	-0.2	-1.3	-0.8	-0.4	-1.0	-1.2
Multivitamins +/- minerals	0.2	0.3	0.8	-0.4	-0.1	-0.9	0.2	0.1	-0.6	-0.9
Stomach or abdominal pain in last month	2.1	2.7	4.6	2.1	1.4	2.0	0.6	0.2	2.0	1.8
Supplements: Glucosamine	1.9	2.5	5.5	1.2	-0.8	2.0	-0.6	2.3	1.4	2.0
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	5.1	1.5	1.9	1.1	2.3	-0.7	1.1	0.9
Medication: Atenolol	0.3	0.3	1.0	-0.2	-1.0	0.3	-0.1	1.0	-0.4	0.3
Medication: Levothyroxine sodium	0.2	0.3	0.9	-0.2	-0.9	0.2	-0.3	0.9	0.4	0.2
Sitting height	0.8	5.3	15.7	-2.5	-2.6	-1.5	-4.0	1.3	-1.3	-1.7
Chronic bronchitis/emphysema (father)	0.8	1.0	1.8	0.6	-0.9	1.3	-0.9	1.1	-0.4	1.3
High blood pressure (mother)	0.7	1.0	4.0	1.1	0.6	0.7	2.0	-0.5	-0.1	0.7
Body mass index (BMI)	1.0	4.3	8.9	2.0	3.0	2.0	1.0	-2.3	1.7	2.1
Impedance of leg (left)	0.4	1.7	9.4	1.1	0.5	0.2	3.1	0.8	0.5	0.3
Leg predicted mass (left)	0.5	2.9	12.7	-1.8	-1.3	-0.8	-3.6	-0.7	-1.1	-0.7
Trunk fat mass	0.5	2.0	4.6	1.2	1.9	1.1	0.7	-2.1	0.8	1.2
Waist circumference	0.3	1.2	4.5	0.0	1.9	0.2	0.6	-2.1	0.3	0.2
Number of incorrect matches in round	0.3	0.6	1.8	0.3	1.3	0.5	-0.6	0.1	1.2	0.3
Past tobacco smoking	0.7	1.2	2.7	-1.2	-1.6	-1.0	-0.1	1.6	0.1	-1.0
Alcohol usually taken with meals	0.8	1.3	3.4	-1.0	-1.8	-0.5	-1.3	1.5	-0.5	-0.5
Nervous feelings	0.2	0.3	1.2	-0.0	-0.8	-0.4	0.2	0.2	-1.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.5	0.3	0.3	0.2	0.3	0.3	0.7	0.3
Hearing difficulty/problems with background noise	0.2	0.3	0.9	-0.6	0.4	-0.5	0.5	-0.9	-0.0	-0.4
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	-0.1	-1.2	0.1	-1.1	1.4	-0.8	0.2
Had menopause	2.2	2.7	7.5	0.1	2.7	-1.1	2.1	-2.3	0.2	-1.0
Had other major operations	0.9	1.1	2.0	1.3	-0.1	1.4	-1.0	0.8	0.7	1.4
Forced vital capacity (FVC)	1.0	3.8	9.9	-0.5	-2.9	0.6	-3.1	2.7	-0.0	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.9	1.2	0.7	1.2	0.3	0.1	0.1	1.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	4.6	1.0	-0.9	1.2	-0.7	2.1	0.1	1.1
Qualifications: None of the above	0.3	0.6	1.1	1.0	0.7	1.0	0.2	0.8	0.3	1.0
Financial difficulties in last 2 years	0.7	1.0	3.3	0.4	1.1	0.8	0.8	-0.5	1.8	0.7
Mouth/teeth dental problems	0.3	0.4	1.1	-0.8	-0.3	-0.8	-1.0	-0.3	0.4	-0.6
Heart attack	0.1	0.2	0.9	0.1	0.3	0.2	0.2	-1.0	0.3	0.2
Allergy	0.2	0.5	1.8	0.5	-0.9	0.5	-0.0	1.3	0.5	0.4
Pain all over the body in last month	0.4	0.4	0.9	-0.7	0.3	-0.5	-1.0	-0.6	0.6	-0.4
Diabetes (self-reported)	0.9	1.4	3.2	-1.8	0.2	-1.4	0.4	-1.3	-0.2	-1.6
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.2	-0.1	1.3	-0.5	1.3	-1.8	-1.5	-0.4
Medication: Ramipril	0.9	1.2	4.7	0.7	-0.6	1.1	-2.2	0.1	-0.9	1.0
Medication: Simvastatin	0.8	1.2	3.7	-0.2	1.4	-0.6	1.3	-1.9	0.1	-0.7
Fluid intelligence score	0.5	1.1	3.9	-0.9	1.0	-0.6	-0.8	-2.0	-0.8	-0.7
Illnesses of siblings	1.9	2.7	5.5	-2.4	-1.4	-1.6	-1.5	-0.1	-1.6	-2.0
Neuroticism score	0.6	1.2	1.9	1.4	-0.5	1.2	-0.4	1.4	1.1	1.2
Weight	0.1	0.7	2.8	-0.6	0.3	-0.0	-1.7	-1.2	-0.3	0.0
Impedance of arm (right)	0.7	3.3	5.9	-1.6	-0.8	-2.4	2.0	-0.2	-2.0	-2.4
Arm fat percentage (right)	1.0	4.0	8.8	1.5	3.0	1.2	2.1	-3.0	0.7	1.2
Trunk fat-free mass	1.1	6.1	22.9	-2.6	-2.4	-1.4	-4.8	0.3	-1.8	-1.3
Hip circumference	0.1	0.6	2.7	0.1	1.1	0.3	-0.1	-1.6	0.1	0.4
Time employed in main current job	0.2	0.2	0.9	0.3	0.1	0.4	0.9	-0.0	-0.3	0.4
Alcohol intake versus 10 years previously	3.1	4.6	10.2	2.8	1.2	3.2	1.2	0.4	1.3	3.1
Father’s age at death	1.1	1.5	5.2	-0.5	-2.0	0.3	-0.7	2.3	-0.6	0.0
Worrier / anxious feelings	0.6	1.1	2.0	1.4	-0.1	1.2	-0.3	1.2	1.2	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.7	0.2	0.6	0.1	-0.0	-0.2	1.6	0.3
Falls in the last year	0.7	1.0	3.8	0.8	1.2	0.5	1.9	-0.3	0.9	0.4
Hair/balding pattern: Pattern 3	0.2	0.4	0.8	0.2	0.6	-0.1	0.9	-0.8	-0.8	-0.3
Number of live births	0.4	0.6	1.7	-0.2	1.2	-0.4	0.5	-1.3	0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.9	-0.1	-2.2	0.6	-1.9	2.1	0.4	0.8
Pulse rate	2.2	3.7	13.5	0.0	-2.8	0.7	-1.8	3.7	0.6	0.9
Happiness	1.8	2.1	4.8	2.2	0.3	1.9	1.2	0.6	0.9	1.9
Noisy workplace	0.5	0.6	1.3	-1.0	-0.3	-1.2	0.7	0.1	0.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	-0.6	0.4	-0.6	1.0	-0.7	-0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	-1.0	-0.8	-0.7	-0.4	1.1	-0.6	-0.8
Mouth/teeth dental problems: Dentures	0.8	1.4	4.7	0.5	-0.9	1.1	-0.9	2.2	0.9	1.0
Asthma	1.1	2.2	5.6	0.5	2.4	0.6	2.1	-1.9	0.8	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.1	-0.2	-0.1	0.4	0.1	-0.2	-0.1
Medication: Cholesterol lowering	0.8	1.3	4.8	0.3	1.5	0.4	1.2	-2.2	-0.2	0.3
Depression (self-reported)	1.3	1.5	4.5	0.5	-0.9	0.8	-0.0	2.1	1.9	0.8
Medication: Lansoprazole	0.6	0.7	1.5	-0.4	0.6	-0.8	0.3	-1.2	-1.2	-0.8
Prospective memory result	1.6	2.0	4.6	1.4	0.4	2.0	-0.4	0.9	1.4	2.1
Lung cancer (father)	0.4	0.5	2.0	0.2	-0.3	0.2	-1.4	0.4	-1.0	0.1
Illnesses of mother	2.0	2.5	7.1	-1.4	-2.7	-0.8	-2.0	1.5	-0.5	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.4	0.6	-1.5	1.2	-1.8	1.9	0.9	1.4
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	-0.6	-0.6	-0.2	-0.7	0.8	0.0	-0.3
Impedance of arm (left)	0.4	2.0	5.7	-0.9	-0.5	-1.7	2.4	-0.1	-1.1	-1.7
Arm fat mass (right)	0.7	3.0	7.8	1.3	2.6	1.2	0.9	-2.8	0.8	1.2
Trunk predicted mass	1.1	6.1	22.4	-2.7	-2.4	-1.4	-4.7	0.3	-1.9	-1.3
Standing height	2.1	21.3	32.5	-5.5	-5.6	-4.1	-5.7	2.1	-4.1	-4.1
Length of working week for main job	3.1	3.4	6.8	-1.7	0.6	-2.4	1.8	-1.5	-1.6	-2.6
Exposure to tobacco smoke at home	0.6	0.7	1.4	-1.2	-0.4	-1.1	-0.8	0.1	-0.5	-1.0
Breastfed as a baby	0.1	0.1	0.5	-0.4	-0.3	0.0	-0.7	0.2	0.4	0.0
Tense / ‘highly strung’	0.3	0.5	0.9	0.9	0.5	0.7	0.9	-0.1	0.7	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	6.1	2.5	1.2	1.6	1.2	-0.1	1.3	1.5
Hair/balding pattern: Pattern 4	0.1	0.2	0.9	0.4	-0.0	0.3	-0.1	0.7	0.9	0.3
Birth weight of first child	1.5	2.7	8.4	-1.3	-2.9	-1.0	-1.4	0.7	-2.1	-0.9
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.3	0.4	0.5	0.2	-0.2	0.7	0.5
Pulse wave reflection index	0.5	0.6	1.1	-0.6	0.4	-1.0	0.3	-0.8	-1.0	-1.0
Ever highly irritable/argumentative for 2 days	1.8	2.2	3.7	1.9	0.2	1.7	0.9	1.0	1.8	1.8
Loud music exposure frequency	0.3	0.4	1.5	-0.2	-0.7	0.2	0.3	1.2	0.6	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.1	0.1	-0.5	0.4	0.3	0.4	-1.1	0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.4	-0.3	-0.8	-0.5	0.4	0.6	-1.5	-0.5
Blood clot in the leg (DVT)	0.3	0.4	1.1	0.5	1.1	0.3	0.3	-1.1	-0.5	0.3
Medication: Paracetamol	0.5	0.8	3.1	-0.4	-1.8	-0.1	-0.7	1.3	-0.4	-0.1
Headache pain in last month	0.5	0.8	2.3	-0.6	-1.2	-0.9	-0.3	0.4	-1.5	-0.8
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	5.7	-0.5	-1.8	-0.4	-0.7	2.4	0.6	-0.4
Glaucoma (self-reported)	0.7	0.9	1.7	-1.3	-0.0	-1.0	-0.7	-0.7	-1.1	-1.2
Gout (self-reported)	0.9	1.3	2.4	-1.6	-1.5	-0.8	-1.3	0.4	-1.0	-0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.4	-0.6	0.8	0.2	0.9	0.6	0.7
Medication: Amlodipine	1.5	2.1	4.1	-2.0	-1.1	-1.7	-1.7	0.3	-1.3	-1.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.4	-0.6	0.4	-0.6	0.6	-0.3	-0.5	-0.6
Birth weight	1.4	3.0	7.8	-0.9	-2.5	-0.7	-2.8	2.2	-0.7	-0.6
Chronic bronchitis/emphysema (mother)	2.1	2.5	9.2	0.1	2.6	-0.1	0.6	-3.0	0.9	-0.1
High blood pressure (siblings)	1.0	1.4	2.5	1.4	1.6	1.1	0.9	-0.4	1.4	1.3
Forced vital capacity (FVC), Best measure	0.8	3.0	6.8	0.4	-1.9	1.1	-2.6	2.5	1.0	1.3
Body fat percentage	1.3	5.0	9.3	2.3	3.0	1.9	2.3	-2.5	1.3	1.9
Leg fat percentage (right)	1.4	5.1	8.7	2.5	3.0	2.4	1.8	-1.9	1.5	2.4
Arm fat-free mass (right)	0.5	2.3	13.6	-1.1	-1.0	-0.1	-3.7	-0.3	-0.5	-0.1
Exposure to tobacco smoke outside home	1.2	1.7	3.4	-1.8	-1.2	-1.7	-0.9	0.1	-0.4	-1.7
Comparative body size at age 10	0.3	1.0	2.2	0.4	-1.4	0.8	-1.5	1.1	-0.1	0.7
Number of full brothers	0.3	0.3	1.0	-0.3	-0.2	-0.7	0.7	0.2	-1.0	-0.5
Worry too long after embarrassment	0.4	0.6	3.1	-0.1	-0.9	0.3	-1.8	0.6	-0.0	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.4	1.1	-0.3	0.5	1.0	1.4	1.8	0.5
Wheeze or whistling in the chest in last year	0.2	0.3	1.5	-0.3	0.8	-0.3	0.3	-1.2	-0.2	-0.2
Number of children fathered	3.6	4.0	8.1	2.8	1.3	2.4	0.7	-0.2	2.3	2.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.1	-0.7	0.4	-0.8	-0.7	-1.1	-0.9	-0.9
Age at first live birth	0.5	0.8	2.8	1.0	-0.1	0.7	1.7	-0.8	-0.7	0.6
Pulse wave peak to peak time	0.1	0.1	0.4	0.4	0.3	0.1	0.3	-0.7	-0.4	0.2
Health satisfaction	0.7	0.9	1.7	1.3	0.0	1.2	0.8	0.4	0.8	1.3
Shortness of breath walking on level ground	1.8	2.1	3.3	1.8	1.2	1.5	1.7	-0.4	1.7	1.3
Qualifications: College or University degree	0.5	1.6	3.3	-0.8	0.7	-1.5	1.0	-1.8	-0.8	-1.6
Eye problems/disorders: None of the above	0.6	0.7	3.7	0.6	0.4	-0.0	1.9	-0.3	-0.4	0.2
Mouth/teeth dental problems: Loose teeth	2.3	2.7	5.3	-2.0	-0.5	-1.9	-0.1	-1.4	-2.3	-2.0
Emphysema/chronic bronchitis	1.1	1.2	2.3	1.1	-0.4	1.4	-0.5	0.9	1.2	1.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.4	0.5	0.5	-0.3	0.2	0.7	0.4
Neck or shoulder pain in last month	0.2	0.3	1.9	-0.0	0.6	-0.2	1.4	-0.1	0.3	-0.1
Medication: Blood pressure	0.4	0.7	2.6	-0.0	1.2	0.1	-0.9	-1.6	-0.2	0.0
Angina (self-reported)	1.0	1.3	2.0	1.2	1.4	1.2	0.4	-1.3	1.1	1.1
Migraine (self-reported)	1.3	1.6	5.6	0.7	-1.9	0.7	0.4	2.4	0.2	0.9
Medication: Ibuprofen	0.1	0.1	0.2	-0.0	-0.4	-0.0	-0.2	0.4	0.2	-0.1
Medication: Allopurinol	0.9	1.2	3.4	-1.5	-1.2	-0.7	-1.8	0.5	-0.3	-0.8
Medication: Omeprazole	2.5	3.0	4.4	2.1	1.6	1.8	1.5	-1.0	1.9	1.9
Medication: Seretide 50 evohaler	1.9	2.1	5.8	0.2	1.9	-0.3	2.3	-2.4	-0.5	-0.4
Mean time to correctly identify matches	0.8	1.6	2.8	-1.5	-0.8	-1.5	-0.5	-0.5	-1.6	-1.7
Heart disease (mother)	4.7	5.8	10.2	3.2	2.5	2.7	1.7	-0.7	2.6	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.7	0.5	0.9	0.5	1.3	0.0	0.2	0.5
Whole body fat mass	0.5	2.2	4.7	1.3	2.1	1.3	0.7	-2.2	0.7	1.4
Leg fat mass (right)	0.6	2.2	4.0	1.4	2.0	1.6	0.4	-1.8	0.9	1.7
Arm predicted mass (right)	0.3	1.8	10.8	-0.8	-0.8	0.1	-3.3	-0.4	-0.5	0.1
Pulse rate, automated reading	0.2	0.6	1.9	-0.5	-1.0	-0.1	-0.9	1.4	0.6	0.1
Alcohol intake frequency.	1.3	3.0	5.4	1.9	0.7	2.2	1.0	1.2	2.3	2.1
Comparative height size at age 10	1.3	7.2	11.8	-3.3	-3.1	-2.6	-3.4	1.1	-2.0	-2.6
Number of full sisters	2.8	3.4	5.9	2.4	1.9	1.9	1.6	-0.7	1.8	2.1
Suffer from ‘nerves’	0.3	0.5	1.9	0.7	1.4	0.2	0.6	-1.0	-0.1	0.0
Overall health rating	0.1	0.2	0.4	0.3	0.3	0.5	0.3	-0.3	0.5	0.6
Chest pain or discomfort	0.8	1.2	3.2	1.0	1.8	0.5	0.6	-1.6	0.8	0.5
Had major operations	0.5	0.5	0.8	0.9	0.8	0.8	0.1	0.4	0.9	0.9
Age at last live birth	0.6	0.8	1.9	0.9	0.8	1.0	1.4	-0.9	0.4	0.8
Family relationship satisfaction	1.0	1.3	2.4	1.2	-0.3	1.2	0.6	1.5	1.1	1.3
Leg pain on walking	0.7	0.9	2.4	0.6	-0.8	0.8	-0.5	1.6	0.9	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	5.1	-0.1	1.8	-0.3	1.6	-2.3	0.9	-0.3
Commuting to job workplace: Car/motor vehicle	1.6	1.9	3.5	1.9	1.2	1.6	0.8	-0.1	1.2	1.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	-0.1	-0.2	0.2	-0.8	-0.5	-0.8	0.2
Medication: Aspirin	2.9	3.8	10.2	-1.9	0.8	-2.1	0.1	-3.2	-2.0	-2.0
Supplements: Vitamin C	0.3	0.4	1.1	-0.4	-1.0	0.2	-0.8	0.4	-0.7	0.1
Knee pain experienced in last month	1.4	2.2	5.6	1.4	2.4	1.3	0.9	-0.7	1.8	1.3
Hypertension (Self-reported)	0.1	0.4	1.2	-0.7	-0.7	0.0	-1.1	0.1	-0.5	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.5	0.3	-0.0	-0.2	0.5	-0.7	-0.5	-0.2
Illnesses of father: Heart disease	0.6	0.9	2.0	1.4	0.5	1.0	0.2	0.4	1.2	1.2
Illnesses of siblings: Diabetes	2.7	3.4	7.8	2.8	0.9	2.4	1.4	0.2	0.9	2.6
Smoking status: Previous	0.7	1.1	3.7	0.4	1.8	-0.1	0.6	-1.9	0.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	5.4	-2.3	-1.6	-2.3	-1.7	0.1	-1.8	-2.3
Whole body fat-free mass	0.8	4.3	18.2	-2.1	-1.9	-1.0	-4.3	-0.1	-1.3	-0.9
Leg fat-free mass (right)	0.5	2.9	11.9	-1.8	-1.2	-0.9	-3.5	-0.8	-1.1	-0.9
Arm fat percentage (left)	1.1	4.5	9.5	1.8	3.1	1.4	2.2	-3.0	1.0	1.4
Average weekly red wine intake	0.7	1.0	3.0	-0.6	-1.7	-0.4	-1.4	1.0	0.9	-0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.1	-0.4	1.0	-0.7	0.1	-1.4	-0.8	-0.6
Mood swings	1.0	1.8	3.5	1.9	0.7	1.4	1.3	0.6	1.8	1.3
Loneliness, isolation	0.1	0.1	0.4	-0.2	0.3	-0.0	0.5	-0.6	0.5	-0.0
Long-standing illness, disability or infirmity	0.3	0.5	1.3	-1.1	-0.5	-0.6	-1.0	-0.4	-0.2	-0.7
Ever had bowel cancer screening	0.2	0.2	0.7	0.2	0.5	0.0	0.9	-0.6	-0.1	-0.1
Diabetes diagnosed by doctor	0.6	1.0	2.3	-1.3	0.5	-1.0	0.5	-1.5	-0.0	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.6	-0.0	-0.1	0.2	-0.8	-0.5	-0.2	0.2
Friendships satisfaction	0.5	0.6	2.9	0.6	0.8	0.5	0.1	0.1	1.7	0.6
Qualifications: nursing, teaching	1.1	1.7	4.3	0.9	-1.8	1.3	-0.9	2.1	0.1	1.2
Commuting to job workplace: Walk	0.7	0.7	1.8	-0.9	-1.4	-0.5	-1.0	1.0	0.0	-0.7
Eye problems/disorders: Cataract	1.8	2.1	4.3	1.3	0.3	1.6	-1.6	1.0	2.1	1.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	2.5	0.2	0.3	-0.1	1.6	-0.4	-0.5	-0.2
Medication for cholesterol	0.3	0.5	1.3	1.1	0.5	0.5	0.8	-0.2	1.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.8	-1.1	-1.4	-1.0	0.3	1.3	-0.7	-1.0
Back pain experienced in last month	0.5	0.8	1.4	-0.7	0.7	-1.2	0.9	-0.9	-0.0	-1.1
Mineral and other dietary supplements	0.1	0.1	0.3	-0.3	0.4	-0.5	-0.1	-0.1	-0.3	-0.5
Breast cancer (self-reported)	1.0	1.2	3.5	-0.5	-1.9	0.2	-1.3	1.7	-0.0	0.1
Asthma (self-reported)	1.3	2.6	6.6	0.5	2.6	0.6	2.3	-2.2	0.9	0.4
Osteoporosis (self-reported)	1.0	1.3	3.9	-1.0	0.9	-1.1	0.1	-2.0	-1.0	-1.0
Osteoarthritis (self-reported)	1.4	1.8	3.0	1.6	1.4	1.6	0.9	0.2	1.4	1.7
Medication: Aspirin	2.5	3.2	10.2	-1.3	1.5	-1.7	0.6	-3.2	-1.4	-1.7
Medication: Gliclazide	0.7	0.8	1.8	-0.9	0.7	-1.3	-0.2	-0.9	-0.4	-1.3
Illnesses of father: None of the above (group 1)	1.3	1.6	3.0	-1.4	-0.9	-1.5	-0.2	0.3	-1.7	-1.7
Smoking status: Current	0.4	0.6	1.4	0.1	-1.1	0.5	-0.9	1.2	-0.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	5.3	0.7	-1.4	1.7	-1.8	2.3	0.7	1.6
Whole body water mass	0.8	4.4	18.6	-2.1	-1.9	-1.0	-4.3	-0.1	-1.4	-0.9
Leg predicted mass (right)	0.5	2.8	11.6	-1.8	-1.2	-0.9	-3.4	-0.8	-1.2	-0.8
Arm fat mass (left)	0.6	2.4	6.0	1.2	2.3	1.2	0.7	-2.5	0.8	1.2
Number of self-reported non-cancer illnesses	0.5	0.9	2.8	0.3	1.3	0.5	0.8	-1.7	0.6	0.3
Average weekly champagne plus white wine intake	0.5	0.7	1.7	0.7	-1.0	0.8	-0.6	1.3	0.3	0.8
Miserableness	0.4	0.8	3.5	0.9	0.7	0.5	-0.0	-0.1	1.9	0.5
Guilty feelings	0.2	0.4	0.8	0.9	-0.5	0.8	-0.1	0.3	0.5	0.7
Wears glasses or contact lenses	4.9	5.7	11.0	2.2	-1.1	2.9	-0.8	3.3	2.6	2.6
Ever taken oral contraceptive pill	0.2	0.2	0.9	-0.0	-0.9	0.6	0.1	0.2	-0.1	0.6
Hearing aid user	0.1	0.1	0.1	-0.2	0.2	-0.3	-0.3	-0.2	-0.2	-0.3
Mother’s age at death	0.3	0.3	0.8	-0.2	-0.5	-0.5	-0.9	0.7	-0.6	-0.2
Financial situation satisfaction	0.3	0.3	1.6	0.3	0.6	-0.1	-0.5	-0.1	1.3	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.3	0.1	-0.5	-0.4	0.3	0.6	-0.3
Commuting to job workplace: Public transport	0.3	0.4	1.6	-0.6	-0.3	-0.4	-0.4	-1.3	-0.6	-0.5
Eye problems/disorders: Glaucoma	1.0	1.2	2.2	-1.4	0.3	-1.1	-1.5	-0.8	-0.9	-1.2
Medication: Blood pressure	0.5	0.9	2.0	-1.4	-0.4	-1.0	-0.8	-0.3	-1.1	-1.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.6	1.9	-0.1	2.1	0.1	1.9	0.7	2.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	-0.5	-0.1	-0.5	-0.0	0.1	0.6	-0.6
High cholesterol (Self-reported)	0.1	0.1	0.6	-0.2	0.4	0.0	0.3	-0.1	0.8	-0.1
Medication: Bendroflumethiazide	0.6	0.9	3.2	-1.0	-0.8	-0.4	-1.8	1.1	-0.2	-0.5
Medication: Paracetamol	0.2	0.3	1.0	0.3	-0.5	0.5	-0.1	1.0	0.5	0.5
Medication: Lisinopril	0.4	0.5	2.0	-0.2	1.4	-0.5	-0.2	-0.9	-0.0	-0.4
Medication: Atorvastatin	0.0	0.0	0.1	-0.1	0.1	0.3	-0.1	0.0	0.0	0.3
Illnesses of father: High blood pressure	0.3	0.4	1.0	0.7	0.2	0.8	-0.0	0.2	1.0	0.8
Alcohol drinker status: Never	1.1	1.4	2.3	-1.3	-1.5	-1.2	-0.7	1.2	0.5	-1.3
Ever smoked	0.2	0.4	0.7	0.7	0.8	0.5	-0.4	-0.8	-0.7	0.5
Basal metabolic rate	0.5	2.8	13.4	-1.7	-1.3	-0.6	-3.7	-0.4	-1.0	-0.6
Leg fat percentage (left)	1.9	6.8	11.9	2.8	3.5	2.5	2.5	-2.4	1.7	2.6
Arm fat-free mass (left)	0.4	2.3	12.5	-1.2	-1.1	-0.2	-3.5	-0.2	-0.8	-0.2
Number of operations (self-reported)	0.3	0.5	1.5	0.0	-0.5	0.3	-1.2	1.2	-0.1	0.2
Average weekly beer plus cider intake	0.2	0.2	0.9	0.1	-0.3	0.3	-0.9	0.6	0.2	0.3
Irritability	0.6	1.0	2.2	-1.2	-0.4	-1.4	0.7	0.3	-0.7	-1.5
Risk taking	2.1	3.1	7.6	-1.7	-0.0	-2.2	0.8	-1.2	-2.8	-2.1
Ever had prostate specific antigen (PSA) test	0.0	0.1	0.2	0.3	0.1	0.0	0.2	0.1	-0.5	-0.1
Fractured/broken bones in last 5 years	0.9	1.2	3.7	-0.2	1.5	-0.5	1.4	-1.9	-0.0	-0.5
Age started oral contraceptive pill	0.2	0.3	0.7	-0.5	-0.6	-0.4	-0.9	0.4	-0.2	-0.3
Diastolic blood pressure, automated reading	0.2	0.5	1.1	0.4	1.0	0.2	0.9	-0.4	1.0	0.3
Ever depressed for a whole week	1.5	1.8	3.8	2.0	0.3	1.8	0.6	1.4	0.6	1.7
Unable to work because of sickness or disability	1.0	1.3	4.4	-0.3	-1.6	0.5	-1.2	2.1	0.3	0.5
Commuting to job workplace: Cycle	0.2	0.3	0.6	-0.2	0.5	-0.4	0.8	-0.6	0.5	-0.6
Myopia	1.6	2.3	6.0	1.5	2.4	0.6	1.8	-1.1	1.7	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.9	0.6	0.4	-0.0	1.4	0.1	0.3	0.1
Cholesterol lowering medication	0.4	0.6	1.2	-1.1	-0.6	-0.9	-0.8	0.5	-0.3	-0.9
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	4.4	2.1	1.1	2.0	1.0	-0.6	1.4	2.0
Pain experienced in last month	0.7	1.3	2.2	-1.3	-1.5	-0.7	-1.5	0.6	-1.1	-0.9
Supplements: Calcium	0.1	0.1	0.3	-0.2	-0.6	-0.2	0.4	-0.4	0.2	-0.1
Basal cell carcinoma (self-reported)	0.5	0.5	2.0	0.2	-1.0	0.2	-0.3	1.4	0.8	0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	0.5	0.4	0.5	0.2	-1.0	0.5	0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	0.7	1.1	0.5	0.5	-0.7	-0.3	0.5
Heart disease (siblings)	0.7	0.8	3.1	1.8	0.6	0.8	0.3	0.3	0.2	1.1
Alcohol drinker status: Previous	2.7	3.1	4.7	2.0	2.1	1.8	1.6	-0.4	2.2	1.7
Pack years of smoking	0.3	0.5	1.8	-0.0	-0.8	0.1	-0.9	1.4	-0.1	0.1
Impedance of whole body	0.3	1.5	9.1	0.1	0.1	-0.8	3.0	0.4	-0.3	-0.8
Leg fat mass (left)	0.7	2.9	5.6	1.6	2.4	1.7	0.7	-2.2	1.0	1.7
Arm predicted mass (left)	0.5	2.4	12.6	-1.4	-1.2	-0.3	-3.5	-0.1	-0.8	-0.2