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chr3:36,395,598-38,766,338

Best TWAS P=5.89e-19 · Best GWAS P=5.29e-20 conditioned to 0.00225

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PLCD1	0.07	0.02	lasso	4	0.03	4.2e-04	3.5	7.2	6.3e-13	0.73	0.01	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	VILL	0.26	0.38	lasso	3	0.38	1.9e-49	8.2	-8.6	6.4e-18	-0.99	0.03	0.97	FALSE
3	GTEx	Brain Caudate basal ganglia	VILL	0.35	0.38	lasso	8	0.33	3.9e-10	8.3	-8.7	2.5e-18	-0.97	0.01	0.99	FALSE
4	GTEx	Brain Cortex	VILL	0.33	0.29	lasso	2	0.25	1.8e-07	8.2	-8.5	2.3e-17	-0.89	0.20	0.79	FALSE
5	GTEx	Brain Frontal Cortex BA9	VILL	0.31	0.30	enet	11	0.34	7.9e-10	8.2	-8.6	5.9e-18	-0.86	0.06	0.93	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	VILL	0.31	0.13	lasso	6	0.12	5.2e-04	8.3	-8.9	5.9e-19	-0.86	0.10	0.68	TRUE
7	GTEx	Brain Putamen basal ganglia	VILL	0.38	0.31	lasso	7	0.26	7.9e-07	8.3	-7.8	5.3e-15	-0.95	0.04	0.91	FALSE
8	GTEx	Esophagus Mucosa	VILL	0.28	0.02	lasso	5	0.04	2.0e-03	6.3	5.4	5.6e-08	0.70	0.02	0.96	FALSE
9	GTEx	Thyroid	LRRFIP2	0.38	0.55	enet	31	0.60	3.8e-56	-5.0	-5.1	2.9e-07	0.00	0.05	0.95	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	VILL	0.34	0.46	lasso	3	0.46	3.1e-65	8.2	-8.4	6.1e-17	-0.96	0.67	0.33	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	PLCD1	0.13	0.12	bslmm	421	0.12	6.6e-15	8.2	-8.4	3.4e-17	-0.80	0.81	0.19	FALSE
12	YFS	Blood	GOLGA4	0.01	0.00	blup	460	0.01	2.2e-03	-4.8	-5.2	1.8e-07	0.01	0.44	0.35	TRUE
13	YFS	Blood	PLCD1	0.07	0.08	enet	15	0.08	8.0e-25	8.2	8.8	1.2e-18	0.85	0.74	0.26	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	PLCD1	0.01	0.02	blup	55	0.01	7.3e-03	8.2	8.1	6.3e-16	0.88	0.03	0.86	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	VILL	0.03	0.01	blup	52	0.01	1.5e-02	8.2	-7.8	8.4e-15	-0.73	0.02	0.48	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	CTDSPL	0.04	0.01	blup	78	0.02	1.0e-03	8.2	-6.3	2.2e-10	-0.66	0.03	0.82	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLCD1	0.05	0.04	enet	8	0.04	6.3e-05	8.2	8.3	7.9e-17	0.81	0.34	0.63	FALSE