Hub : Genes

CTDSPL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1140	0.0430	0.00370	0.016	NA	0.007	NA	0.020	0.029	NA	1.1e-01	NA	0.0170
2	TCGA	Breast Invasive Carcinoma	0.0707	0.0300	0.00039	0.000	0.016	0.023	NA	0.010	0.390	0.00027	1.1e-05	NA	0.0028
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1030	0.0490	0.00098	-0.005	0.010	0.016	NA	-0.002	0.860	0.08200	4.0e-02	NA	0.4700
4	TCGA	Lung Adenocarcinoma	0.0395	0.0185	0.00034	0.010	0.023	0.010	NA	0.014	0.020	0.00100	2.3e-02	NA	0.0078

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	2.4	1.0	-1.6	-1.1	0.1
Bipolar Disorder or Schizophrenia	2.2	5.4	14.5	3.8	-2.0	-0.9	-1.6
Depressed Affect (Nagel 2018)	0.3	0.7	1.4	-0.3	0.8	0.8	1.2
Depression (Nagel 2018)	0.2	0.3	0.9	0.5	1.0	0.2	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.1	0.5	-1.5	-0.6	-0.0
Neuroticism (Nagel 2018)	0.0	0.1	0.1	-0.0	0.3	0.3	0.1
Schizophrenia (2018)	2.8	5.8	16.9	4.1	-1.3	-0.2	-2.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.1	1.4	-0.2	-0.9	-0.7
Worry (Nagel 2018)	0.2	0.3	1.1	-0.3	-0.2	-0.1	-1.1
Alzheimer’s Disease (in mother)	1.6	1.8	4.4	1.7	-2.1	-0.3	-0.2
Alzheimer’s Disease (in father)	0.6	0.7	1.2	1.1	-0.2	-0.9	-0.9
Alzheimer’s Disease (including proxy)	2.5	3.6	5.8	2.4	-2.2	-1.2	-1.6
Crohns Disease (2017)	0.5	1.1	2.4	1.6	0.9	-0.5	-1.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	0.7	0.4	0.0	0.7
Ulcerative Colitis (UC)	0.5	1.0	3.8	-0.3	-0.0	0.1	2.0
Major Depression (MDD)	0.9	1.2	2.8	1.1	0.6	0.4	-1.7
Reaction Time	0.6	1.1	3.5	1.9	-0.4	-0.9	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.7	-0.5	-0.1	0.2
Breast Cancer	0.6	1.5	2.2	1.5	-0.7	-1.0	-1.5
Ovarian Cancer	1.9	2.5	6.2	-1.9	-0.5	-0.1	2.5
Prostate Cancer	1.1	1.6	4.4	2.1	-0.8	-0.9	-0.7
Age at First Birth	1.0	1.5	3.4	0.8	-1.8	-1.0	0.9
Bipolar Disorder (2011)	2.5	2.4	9.1	3.0	0.0	0.0	-0.8
Body Mass Index (BMI) (2010)	0.6	0.9	1.7	1.1	-1.3	-0.6	-0.3
Coronary Artery Disease (CAD)	1.5	1.8	3.2	-1.8	0.8	1.2	1.4
Crohns Disease (2012)	1.2	2.0	5.6	0.6	1.0	-1.0	-2.4
Mean Putamen Volume	0.2	0.3	0.3	-0.5	0.5	0.6	-0.4
Fasting Glucose	1.3	1.5	2.5	0.7	1.5	-0.9	-1.6
HbA1C	0.7	0.8	1.6	0.1	-1.3	1.2	0.1
HDL Cholesterol	0.7	1.2	1.9	-1.4	0.0	1.2	1.2
LDL Cholesterol	0.4	0.6	1.1	-0.2	1.0	1.0	-0.7
Lupus	0.9	1.4	3.6	-0.6	-0.1	1.3	-1.9
Neuroticism (2016)	0.7	1.1	1.6	-0.9	1.0	-1.0	1.2
Primary Biliary Cirrhosis	2.6	3.6	6.3	1.4	1.2	-2.5	-2.2
Rheumatoid Arthritis	0.3	0.4	1.3	0.3	-0.3	1.1	0.2
Schizophrenia (2014)	2.4	5.2	10.1	3.2	-2.5	-1.3	-1.7
Triglycerides	0.4	0.6	1.8	1.3	-0.1	-0.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	-1.2	0.6	-0.2	-0.4
Ulcerative Colitis	0.7	1.0	2.5	-0.9	0.2	0.8	1.6
Blood Eosinophil Count	0.1	1.1	3.9	0.3	2.0	0.7	0.2
Blood Platelet Count	0.1	1.4	2.2	0.2	-1.5	-1.2	1.3
Blood Red Count	2.1	19.9	40.4	-5.1	6.4	3.3	1.5
Blood White Count	0.9	6.7	21.0	-0.9	4.6	0.1	-2.2
Heel T-Score	0.1	0.8	2.3	0.3	-0.8	-0.5	-1.5
BMI	0.2	1.3	2.1	1.2	-1.2	1.4	0.3
Height	1.4	27.1	79.6	-3.9	3.6	-0.7	-8.9
Waist Hip Ratio (WHR)	0.3	1.6	4.2	-0.7	-2.0	0.2	1.2
Systolic Blood Pressure	0.6	3.0	7.2	0.5	2.7	0.1	-2.1
Smoking Status	0.2	0.4	1.0	-0.2	0.6	0.4	-1.0
Allergy or Eczema	0.3	0.8	1.6	-0.1	-0.5	-1.3	-1.2
Cardiovascular Disease	1.1	3.5	5.9	-1.6	2.4	2.4	-0.2
Hypothyroidism (self reported)	0.4	1.0	2.5	-1.6	-0.0	0.5	1.1
Respiratory disease	0.1	0.2	0.4	-0.6	-0.6	-0.3	0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.7	-1.1	1.3	0.9	0.3
Lung FEV1/FVC ratio	1.3	6.8	10.3	2.8	1.0	-3.2	-2.8
Lung FVC	0.2	0.8	2.1	0.9	1.5	0.4	-0.2
Neuroticism	0.1	0.2	0.5	0.7	0.3	-0.1	-0.1
Chronotype (morning person)	1.8	4.2	7.5	-2.3	1.9	2.7	0.9
Hair Pigment	0.0	0.6	1.3	-0.1	-1.1	1.0	0.3
Tanning	0.1	1.5	4.1	1.1	-2.0	0.6	-0.3
Hand grip strength (left)	0.4	1.0	1.9	-0.6	-1.2	-0.3	-1.4
Number of treatments/medications taken	0.3	0.5	1.6	0.4	1.3	0.4	-0.3
Average weekly spirits intake	1.2	1.5	2.9	1.3	-0.4	-1.2	-1.7
Sensitivity / hurt feelings	0.2	0.3	0.8	0.3	0.9	-0.1	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.2	-0.1	-0.5	-0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.6	0.6	-0.1	-1.3	-0.6
Relative age of first facial hair	0.6	1.1	3.2	-0.6	-1.8	-0.1	1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	0.9	-0.1	0.6	-0.6
Ever used hormone-replacement therapy (HRT)	1.8	2.3	5.7	0.9	1.4	-0.9	-2.4
Ever had hysterectomy (womb removed)	0.8	0.9	2.1	-0.4	1.5	-0.9	-0.5
Systolic blood pressure, automated reading	1.2	3.5	7.1	1.4	2.7	0.9	-2.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.0	-0.5	1.4	0.6	-0.4
Angina	0.6	0.8	1.5	0.3	1.2	-0.4	-1.2
Medication for hormone replacement therapy	4.8	5.4	11.0	2.3	-0.8	-2.1	-3.3
Vitamin and mineral supplements	1.1	1.5	4.4	-2.1	-0.4	-0.0	1.2
Supplements: Zinc	2.1	2.3	6.5	2.5	-1.0	-1.2	-0.2
Medication: Co-codamol	0.9	1.0	2.6	1.6	-0.0	0.9	-0.7
Medication: Metformin	0.6	0.9	3.0	0.1	1.7	-0.6	-0.3
Diabetes (father)	0.5	0.6	1.1	1.1	-0.3	0.2	1.0
Diabetes (mother)	2.4	3.1	6.4	0.6	2.5	-1.2	-2.0
Severe depression (siblings)	1.2	1.3	2.6	0.0	-1.3	-1.6	-0.9
Pack years adult smoking proportion	0.4	0.6	1.6	-0.2	-1.3	-0.1	0.9
Impedance of leg (right)	0.8	3.8	8.2	-2.6	2.9	0.3	0.6
Leg fat-free mass (left)	0.5	2.6	8.7	-0.1	-1.3	0.2	-3.0
Trunk fat percentage	0.3	1.0	2.8	-0.1	0.9	0.7	-1.7
Hand grip strength (right)	0.6	1.7	4.5	-1.1	0.2	-1.1	-2.1
Townsend deprivation index at recruitment	0.5	0.7	1.4	1.2	-0.6	-0.1	-1.0
Current tobacco smoking	0.2	0.3	0.8	0.0	0.5	-0.4	-0.9
Average weekly fortified wine intake	0.9	1.1	3.2	-0.3	-0.8	-1.8	0.5
Maternal smoking around birth	1.4	2.0	7.1	0.4	0.8	-0.2	-2.7
Fed-up feelings	0.1	0.1	0.4	-0.6	-0.1	-0.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	-0.7	-0.5	-0.7	0.8
Relative age voice broke	0.9	1.4	2.8	0.5	-1.7	-0.9	1.3
Taking other prescription medications	0.8	1.3	2.1	-1.2	1.1	0.7	1.5
Age when periods started (menarche)	0.5	1.1	2.1	-1.4	-0.3	0.9	1.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.4	0.1	1.2	-0.8	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	0.9	0.1	0.0	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	0.6	1.0	-0.4	0.0
Qualifications: CSEs or equivalent	0.6	0.8	2.0	-0.4	0.4	1.4	1.0
Serious illness, injury or assault to yourself	0.5	0.6	1.5	-1.2	0.8	0.5	0.2
High blood pressure	1.5	4.1	8.5	-0.9	2.9	2.4	-1.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.1	-0.7	-1.4	-0.8	0.1
Multivitamins +/- minerals	1.3	1.6	4.5	2.1	-0.1	0.4	-1.3
Stomach or abdominal pain in last month	1.0	1.2	3.5	0.8	-0.9	0.4	-1.9
Supplements: Glucosamine	0.8	1.1	3.2	1.8	-0.9	-0.4	0.1
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	7.0	-1.2	2.6	-0.2	0.2
Medication: Atenolol	0.8	1.0	2.3	-0.8	0.7	1.5	0.8
Medication: Levothyroxine sodium	0.3	0.5	1.4	-1.2	0.7	-0.2	0.1
Sitting height	2.6	18.4	56.4	-2.2	3.4	-0.8	-7.5
Chronic bronchitis/emphysema (father)	1.2	1.4	1.9	-1.4	-1.2	1.1	1.1
High blood pressure (mother)	0.5	0.6	1.2	0.2	1.1	-0.8	-0.8
Body mass index (BMI)	0.2	0.9	2.0	0.4	-1.1	1.4	0.5
Impedance of leg (left)	0.6	3.1	8.0	-2.0	2.8	0.1	0.4
Leg predicted mass (left)	0.5	2.5	8.4	-0.2	-1.1	0.3	-2.9
Trunk fat mass	0.4	1.8	5.5	-0.5	0.6	1.0	-2.3
Waist circumference	0.1	0.5	1.3	-0.6	-0.4	1.1	-0.7
Number of incorrect matches in round	0.3	0.4	1.1	-0.6	-0.3	-0.3	-1.1
Past tobacco smoking	0.1	0.3	0.4	-0.6	-0.6	-0.1	0.6
Alcohol usually taken with meals	0.4	0.6	1.7	0.3	-0.5	-1.3	-0.6
Nervous feelings	0.5	0.9	3.0	0.2	-1.7	0.1	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.1	-0.8	-1.5	0.5	1.4
Hearing difficulty/problems with background noise	0.6	1.0	3.7	1.9	-0.2	0.0	-0.4
Hair/balding pattern: Pattern 2	0.4	0.5	1.5	1.2	-0.3	-0.4	0.0
Had menopause	3.3	4.1	10.7	-0.4	3.3	-1.3	-2.0
Had other major operations	2.0	2.4	5.9	-1.0	1.3	2.4	1.0
Forced vital capacity (FVC)	0.7	2.5	6.6	-0.3	1.8	0.5	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	0.7	0.1	0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	4.5	0.7	-0.2	-2.1	-0.7
Qualifications: None of the above	0.3	0.7	1.3	0.6	0.3	0.9	-1.2
Financial difficulties in last 2 years	0.6	0.8	2.5	0.1	-1.6	0.8	0.5
Mouth/teeth dental problems	1.0	1.6	2.9	-1.0	-0.2	1.7	1.6
Heart attack	1.3	1.7	2.3	-1.5	1.5	0.5	1.4
Allergy	0.5	1.1	2.0	1.4	1.3	0.3	-0.8
Pain all over the body in last month	0.5	0.6	1.1	0.9	-1.1	-0.5	-0.0
Diabetes (self-reported)	0.3	0.5	1.5	0.2	1.2	0.2	-0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.7	-0.6	-0.4	-1.3	-0.1
Medication: Ramipril	2.1	2.7	4.9	-2.2	1.2	2.0	-0.7
Medication: Simvastatin	5.1	7.5	13.7	-3.7	-0.8	2.8	2.7
Fluid intelligence score	0.2	0.4	1.1	-0.2	-1.1	-0.4	0.6
Illnesses of siblings	0.6	0.8	1.3	1.0	-0.8	1.1	0.7
Neuroticism score	0.0	0.1	0.2	0.3	0.0	-0.4	0.1
Weight	0.4	2.0	6.4	-0.6	-0.2	1.0	-2.5
Impedance of arm (right)	0.2	0.9	2.2	0.2	1.1	-1.5	-0.4
Arm fat percentage (right)	0.2	0.8	1.9	1.1	-1.4	0.5	0.2
Trunk fat-free mass	0.6	3.3	9.5	-1.3	-1.1	0.8	-3.1
Hip circumference	0.2	0.9	2.4	-0.4	0.5	0.9	-1.5
Time employed in main current job	1.6	1.8	4.1	0.1	1.8	0.2	-2.0
Alcohol intake versus 10 years previously	0.4	0.6	1.1	0.9	-1.0	-0.6	0.4
Father’s age at death	2.1	2.8	5.6	1.6	-0.7	-1.6	-2.4
Worrier / anxious feelings	0.2	0.4	0.7	0.7	-0.7	-0.8	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.9	-0.6	0.6	0.9	-0.1
Falls in the last year	1.7	2.3	4.2	-1.1	-0.3	2.0	2.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	0.1	-0.7	-0.4
Number of live births	1.6	2.2	5.3	-0.7	-2.3	0.7	1.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	6.4	0.7	1.1	-0.4	-2.5
Pulse rate	0.3	0.5	1.0	-0.7	0.7	-0.4	1.0
Happiness	1.1	1.3	2.2	-1.3	-1.2	0.1	1.5
Noisy workplace	0.0	0.0	0.1	-0.1	-0.1	0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.7	1.4	5.1	0.6	-2.3	-0.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	0.9	-1.3	-0.2	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	-0.7	1.4	-0.5	0.2
Asthma	1.1	2.2	5.6	-2.4	0.0	1.3	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	5.1	0.9	-1.6	-2.3	-0.9
Medication: Cholesterol lowering	0.7	1.0	2.8	-1.7	0.7	0.6	0.7
Depression (self-reported)	0.4	0.5	1.6	0.0	-1.3	-0.7	0.0
Medication: Lansoprazole	0.2	0.3	0.7	-0.8	0.2	-0.6	0.2
Prospective memory result	1.0	1.2	1.6	-1.2	1.2	1.2	0.7
Lung cancer (father)	1.1	1.3	2.8	-1.2	-0.9	1.7	0.6
Illnesses of mother	0.3	0.4	0.7	0.5	0.1	-0.8	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	9.5	1.5	1.4	-1.2	-3.1
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.7	-0.4	-0.3	0.6
Impedance of arm (left)	0.4	1.8	4.0	-0.4	1.6	-2.0	-0.6
Arm fat mass (right)	0.1	0.5	0.8	0.0	-0.9	0.8	-0.8
Trunk predicted mass	0.6	3.2	9.1	-1.4	-1.0	0.9	-3.0
Standing height	1.2	12.3	40.3	-2.4	1.6	-0.6	-6.3
Length of working week for main job	0.1	0.1	0.2	0.0	-0.5	-0.4	-0.5
Exposure to tobacco smoke at home	1.6	1.7	6.1	0.4	-2.5	0.4	0.7
Breastfed as a baby	0.7	0.8	1.6	-0.4	-1.2	-0.3	1.3
Tense / ‘highly strung’	1.0	1.7	2.8	-0.2	-1.2	-1.7	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.4	0.9	-0.3	-1.2	-0.0
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	0.0	0.9	0.6	0.3
Birth weight of first child	0.5	1.0	1.5	1.1	-1.0	-1.2	-0.2
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.4	-0.3	-0.7	0.0
Pulse wave reflection index	0.5	0.6	1.1	-0.6	-1.1	-0.9	-0.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.6	0.1	-0.6	-1.6	-0.1
Loud music exposure frequency	0.9	1.0	1.8	-0.2	-1.1	1.0	1.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	0.1	0.7	-0.7	-0.3
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	6.1	2.5	-0.9	-1.4	-2.3
Blood clot in the leg (DVT)	2.7	3.5	5.2	-1.9	-0.2	2.2	2.3
Medication: Paracetamol	0.7	1.1	2.0	1.4	-0.8	-1.4	0.1
Headache pain in last month	0.3	0.5	1.1	0.7	-0.3	-1.1	-0.5
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	4.9	1.6	-2.1	-2.2	-0.1
Glaucoma (self-reported)	0.5	0.5	1.2	0.1	-0.9	-0.3	1.1
Gout (self-reported)	0.4	0.5	1.4	0.4	1.2	-0.8	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.8	-1.3	-0.1	0.3	0.8
Medication: Amlodipine	0.3	0.4	1.4	-1.2	0.2	0.0	0.2
Medication: Ventolin 100micrograms inhaler	4.2	5.4	10.0	-3.2	0.6	2.0	2.7
Birth weight	0.1	0.2	0.8	-0.1	-0.9	0.0	-0.2
Chronic bronchitis/emphysema (mother)	2.1	2.4	3.9	-1.3	-2.0	1.9	0.8
High blood pressure (siblings)	0.6	0.9	1.7	-1.3	0.9	-1.0	0.3
Forced vital capacity (FVC), Best measure	0.8	2.8	8.4	0.4	1.6	-0.4	-2.9
Body fat percentage	0.1	0.5	0.9	-0.2	0.6	1.0	-0.9
Leg fat percentage (right)	0.6	2.0	6.0	-0.9	0.9	2.4	0.7
Arm fat-free mass (right)	0.7	3.7	10.6	-1.7	-0.3	1.1	-3.3
Exposure to tobacco smoke outside home	4.3	5.7	10.0	2.6	0.1	-2.5	-3.2
Comparative body size at age 10	0.4	1.0	2.0	1.4	0.1	-1.4	-0.5
Number of full brothers	1.5	1.9	6.0	-0.5	-2.4	1.0	0.5
Worry too long after embarrassment	0.2	0.4	0.7	-0.9	0.7	-0.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.6	1.6	-0.2	-1.1	-1.6
Wheeze or whistling in the chest in last year	0.7	1.2	2.4	-1.5	-1.6	0.2	0.4
Number of children fathered	1.4	1.6	2.5	-1.2	-1.4	-0.3	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.2	-0.1	0.5	-0.3	-1.5
Age at first live birth	1.4	2.5	9.8	0.4	-3.1	-0.3	0.0
Pulse wave peak to peak time	0.5	0.6	1.5	0.7	0.5	0.3	-1.2
Health satisfaction	0.4	0.5	2.1	0.2	-0.2	0.2	1.4
Shortness of breath walking on level ground	1.1	1.3	3.2	-0.3	0.4	-1.8	-1.3
Qualifications: College or University degree	0.2	0.7	2.2	0.4	-1.5	-0.6	0.3
Eye problems/disorders: None of the above	2.8	3.2	6.4	1.9	-0.3	-1.6	-2.5
Mouth/teeth dental problems: Loose teeth	2.2	2.6	3.9	1.7	0.8	-2.0	-1.8
Emphysema/chronic bronchitis	1.9	2.2	4.4	-1.1	-2.1	-1.6	0.9
Medication for pain relief, constipation, heartburn	0.4	0.6	1.5	-0.8	0.3	1.2	0.4
Neck or shoulder pain in last month	0.5	0.8	1.3	0.7	-0.9	-1.1	-0.6
Medication: Blood pressure	1.9	3.4	6.1	-1.5	2.3	2.5	-0.1
Angina (self-reported)	0.4	0.6	1.3	0.1	0.9	-0.4	-1.1
Migraine (self-reported)	0.9	1.1	3.6	0.3	-1.9	-0.6	0.8
Medication: Ibuprofen	1.3	1.5	2.9	0.5	-1.4	-1.7	-1.1
Medication: Allopurinol	0.5	0.6	1.9	0.2	0.2	-1.4	-0.7
Medication: Omeprazole	0.7	0.8	1.8	-0.3	-1.3	1.1	0.3
Medication: Seretide 50 evohaler	2.0	2.3	6.4	-2.5	0.9	1.3	0.5
Mean time to correctly identify matches	0.8	1.5	4.1	2.0	-0.5	-1.3	0.2
Heart disease (mother)	0.5	0.6	1.9	-0.5	1.4	0.5	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.0	-1.0	-0.1	2.0	-0.3
Whole body fat mass	0.3	1.2	2.7	-0.7	0.3	1.2	-1.6
Leg fat mass (right)	0.2	0.9	2.5	-0.5	0.4	1.6	-0.7
Arm predicted mass (right)	0.7	3.5	8.9	-1.6	-0.5	1.5	-3.0
Pulse rate, automated reading	0.3	1.0	1.8	-0.8	1.2	-0.3	1.4
Alcohol intake frequency.	0.1	0.2	0.7	0.5	0.3	-0.8	-0.2
Comparative height size at age 10	1.0	5.6	18.4	-1.3	0.8	-1.2	-4.3
Number of full sisters	0.4	0.5	0.8	-0.4	-0.7	0.6	0.9
Suffer from ‘nerves’	0.4	0.6	1.4	-0.6	-0.1	0.7	1.2
Overall health rating	0.9	2.0	2.8	1.3	1.7	1.0	-1.6
Chest pain or discomfort	0.6	0.9	2.8	1.7	0.5	-0.4	-0.7
Had major operations	1.0	1.2	2.8	1.7	-0.2	-1.0	-0.8
Age at last live birth	3.6	5.2	19.2	0.4	-4.4	-0.4	1.2
Family relationship satisfaction	1.9	2.3	5.4	1.3	-1.5	-2.3	-0.2
Leg pain on walking	0.2	0.3	0.8	0.9	0.3	0.0	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	3.2	-1.8	0.7	0.7	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	-0.6	0.5	1.1	-0.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	5.0	-0.6	2.2	-0.7	-0.3
Medication: Aspirin	0.1	0.2	0.4	0.1	0.3	-0.6	-0.4
Supplements: Vitamin C	1.4	1.6	4.4	0.8	0.4	-2.1	-1.1
Knee pain experienced in last month	1.2	1.8	7.1	0.2	0.2	2.7	0.0
Hypertension (Self-reported)	1.5	4.2	10.7	-0.4	3.3	1.8	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.9	0.4	0.8	0.1
Illnesses of father: Heart disease	0.6	0.8	1.7	0.3	1.3	0.8	0.8
Illnesses of siblings: Diabetes	0.8	0.9	1.7	-0.7	-1.2	-1.3	0.1
Smoking status: Previous	0.4	0.6	1.3	0.5	1.1	0.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.5	-0.4	0.6	-0.3	-1.9
Whole body fat-free mass	0.6	3.2	9.9	-0.8	-1.3	0.7	-3.1
Leg fat-free mass (right)	0.5	2.9	9.5	0.2	-1.4	-0.0	-3.1
Arm fat percentage (left)	0.1	0.4	1.3	0.5	-1.2	0.4	0.2
Average weekly red wine intake	2.0	2.9	4.4	2.1	-2.0	-1.3	-1.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.0	1.1	-1.1	0.5	1.4
Mood swings	0.3	0.5	1.0	1.0	-0.7	-0.0	0.7
Loneliness, isolation	0.0	0.1	0.1	-0.2	0.4	-0.2	0.2
Long-standing illness, disability or infirmity	0.8	1.2	2.4	0.5	1.5	1.5	-0.0
Ever had bowel cancer screening	1.1	1.2	1.6	-1.2	-0.8	1.1	1.3
Diabetes diagnosed by doctor	0.4	0.7	1.3	-1.1	1.1	0.6	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	5.6	1.3	-2.4	-0.4	-0.7
Friendships satisfaction	1.1	1.3	2.1	1.4	-1.4	-0.9	-0.7
Qualifications: nursing, teaching	0.3	0.5	0.9	0.2	-0.7	0.8	1.0
Commuting to job workplace: Walk	0.8	0.9	2.8	0.7	1.7	-0.4	0.0
Eye problems/disorders: Cataract	3.6	4.2	7.9	-2.5	1.2	1.0	2.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.0	-0.5	0.0	0.3
Medication for cholesterol	1.4	2.2	4.2	-0.4	-2.1	-1.4	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.6	0.1	0.9	0.5	-1.2
Back pain experienced in last month	0.5	0.8	2.0	0.8	0.1	0.6	-1.4
Mineral and other dietary supplements	0.4	0.5	1.5	-1.2	0.2	-0.7	-0.2
Breast cancer (self-reported)	0.9	1.1	2.4	0.0	1.6	1.3	0.5
Asthma (self-reported)	0.9	1.7	4.5	-2.1	0.2	1.2	1.0
Osteoporosis (self-reported)	0.3	0.4	1.1	-1.1	0.6	-0.5	-0.0
Osteoarthritis (self-reported)	1.6	2.1	5.3	1.0	0.1	2.3	1.5
Medication: Aspirin	0.1	0.2	0.5	-0.1	0.7	-0.3	-0.4
Medication: Gliclazide	1.0	1.1	2.8	-1.2	0.4	1.7	0.2
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.7	-0.5	-0.3	0.0
Smoking status: Current	0.1	0.1	0.6	-0.2	-0.1	0.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	4.3	2.1	0.8	-0.1	-0.7
Whole body water mass	0.5	3.1	9.6	-0.8	-1.3	0.7	-3.1
Leg predicted mass (right)	0.5	2.8	9.1	0.1	-1.4	0.0	-3.0
Arm fat mass (left)	0.2	0.7	1.2	-0.2	-1.1	1.1	-0.5
Number of self-reported non-cancer illnesses	1.0	1.8	3.8	-1.0	1.2	1.9	0.9
Average weekly champagne plus white wine intake	1.4	2.0	2.8	1.4	-0.7	-1.5	-1.7
Miserableness	0.2	0.3	0.4	0.7	0.6	0.3	0.4
Guilty feelings	0.9	1.3	2.1	1.2	-1.5	-1.3	0.1
Wears glasses or contact lenses	0.7	0.8	1.3	0.6	0.4	1.1	-1.2
Ever taken oral contraceptive pill	0.9	1.0	1.6	1.1	-0.9	-0.8	-1.2
Hearing aid user	0.5	0.6	1.5	0.8	0.1	-0.6	-1.2
Mother’s age at death	0.9	1.1	1.5	1.2	-1.2	-1.2	0.3
Financial situation satisfaction	0.0	0.1	0.1	0.3	-0.0	-0.2	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.8	1.5	0.2	-1.2	1.0	0.7
Commuting to job workplace: Public transport	0.7	0.9	2.8	1.7	0.4	-0.2	-0.7
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	0.0	-1.0	-0.1	1.2
Medication: Blood pressure	0.8	1.5	3.6	-0.7	1.9	1.3	0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.0	0.0	0.3	1.0	-1.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	-0.2	-0.1	0.7	0.8
High cholesterol (Self-reported)	1.9	3.4	7.2	-2.7	0.6	1.6	1.9
Medication: Bendroflumethiazide	1.5	2.2	3.5	-0.9	1.8	1.9	1.1
Medication: Paracetamol	0.5	0.8	1.7	1.3	-0.2	-1.3	-0.1
Medication: Lisinopril	0.4	0.5	0.7	-0.6	0.8	0.3	0.9
Medication: Atorvastatin	3.3	4.1	7.5	-0.2	2.7	-1.6	-2.5
Illnesses of father: High blood pressure	0.4	0.5	1.5	1.2	0.1	0.4	0.5
Alcohol drinker status: Never	0.2	0.2	0.5	-0.2	0.7	-0.2	-0.5
Ever smoked	0.3	0.6	1.1	1.0	0.7	-0.4	-0.7
Basal metabolic rate	0.5	2.8	9.1	-0.8	-1.0	0.7	-3.0
Leg fat percentage (left)	0.5	1.7	5.5	-0.6	0.8	2.4	0.7
Arm fat-free mass (left)	0.5	2.6	7.1	-1.2	-0.7	1.2	-2.7
Number of operations (self-reported)	0.1	0.2	0.5	-0.2	-0.1	0.7	0.4
Average weekly beer plus cider intake	1.0	1.5	4.2	1.2	-0.4	0.6	-2.0
Irritability	0.2	0.3	0.9	0.9	-0.1	-0.4	-0.3
Risk taking	0.4	0.7	1.7	0.5	-1.3	0.2	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.4	0.8	0.0	0.1
Fractured/broken bones in last 5 years	1.1	1.4	3.1	-0.9	-0.7	1.0	1.8
Age started oral contraceptive pill	0.2	0.3	0.8	-0.4	0.2	0.9	0.2
Diastolic blood pressure, automated reading	0.5	1.5	4.7	1.0	0.5	2.2	0.4
Ever depressed for a whole week	3.2	3.9	10.6	0.8	-1.8	-3.2	-1.2
Unable to work because of sickness or disability	1.3	1.7	4.4	1.0	0.4	-1.2	-2.1
Commuting to job workplace: Cycle	2.0	2.4	5.7	0.7	-1.1	-2.4	-1.5
Myopia	0.9	1.2	2.9	0.2	-1.4	-0.2	1.7
Vascular/heart problems diagnosed by doctor	1.4	3.8	8.2	1.1	-2.9	-2.2	0.8
Cholesterol lowering medication	1.5	2.2	3.5	-1.9	0.5	1.8	1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	-0.3	-1.0	1.1	0.2
Pain experienced in last month	0.7	1.2	3.5	-1.0	1.9	-0.4	0.3
Supplements: Calcium	0.3	0.3	0.5	0.7	-0.0	-0.6	-0.5
Basal cell carcinoma (self-reported)	0.4	0.4	1.1	-1.1	0.2	0.5	-0.5
Heart attack/myocardial infarction (self-reported)	1.8	2.3	3.4	-1.9	1.6	0.9	1.6
Deep venous thrombosis (DVT) (self-reported)	2.6	3.4	6.7	-1.6	-0.6	1.9	2.6
Heart disease (siblings)	0.5	0.6	1.6	-0.6	1.3	0.5	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.2
Pack years of smoking	0.4	0.5	1.1	-0.5	-1.0	-0.2	0.9
Impedance of whole body	0.5	2.4	5.9	-1.3	2.4	-1.3	-0.4
Leg fat mass (left)	0.2	0.8	2.0	-0.5	0.5	1.4	-0.8
Arm predicted mass (left)	0.5	2.8	7.5	-1.2	-0.8	1.3	-2.7