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chr16:86,671-1,962,132

Best TWAS P=1.7e-09 · Best GWAS P=1.3e-09 conditioned to 0.000149

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	WDR24	0.08	0.06	lasso	2	0.08	9.0e-07	4.7	5.2	1.9e-07	0.02	0.02	0.97	FALSE
2	GTEx	Adipose Subcutaneous	LA16c-313D11.12	0.09	0.04	lasso	4	0.02	1.1e-02	5.2	5.3	1.3e-07	0.02	0.01	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	WDR24	0.12	0.09	lasso	2	0.07	1.0e-04	5.2	5.2	1.8e-07	0.03	0.01	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	WDR90	0.18	0.19	enet	5	0.18	9.7e-10	5.1	5.2	2.1e-07	0.03	0.02	0.98	FALSE
5	GTEx	Artery Aorta	WDR24	0.13	0.09	lasso	3	0.05	9.1e-04	5.2	5.3	1.1e-07	0.03	0.01	0.97	FALSE
6	GTEx	Artery Aorta	WDR90	0.19	0.15	lasso	4	0.18	3.6e-10	5.1	5.1	2.6e-07	0.04	0.02	0.98	FALSE
7	GTEx	Artery Tibial	WDR90	0.11	0.09	enet	6	0.10	1.8e-08	5.2	5.3	1.2e-07	0.03	0.01	0.99	FALSE
8	GTEx	Artery Tibial	LA16c-349E10.1	0.11	0.11	lasso	4	0.10	1.7e-08	5.1	5.2	1.9e-07	0.03	0.01	0.99	FALSE
9	GTEx	Breast Mammary Tissue	C16orf13	0.35	0.24	lasso	5	0.28	6.5e-15	5.1	5.2	2.4e-07	0.04	0.01	0.98	FALSE
10	GTEx	Cells Transformed fibroblasts	WDR90	0.19	0.15	lasso	7	0.14	1.4e-10	5.1	5.1	2.7e-07	0.02	0.02	0.98	FALSE
11	GTEx	Colon Sigmoid	C16orf13	0.20	0.20	lasso	4	0.15	6.4e-06	5.2	5.4	8.0e-08	0.02	0.01	0.99	FALSE
12	GTEx	Colon Transverse	WDR90	0.26	0.12	lasso	4	0.20	4.5e-10	5.2	6.0	2.3e-09	0.10	0.01	0.99	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	C16orf13	0.33	0.19	lasso	4	0.14	8.5e-06	5.1	5.1	3.1e-07	0.03	0.02	0.97	FALSE
14	GTEx	Esophagus Mucosa	C16orf13	0.11	0.07	lasso	5	0.07	1.2e-05	5.2	5.3	8.8e-08	0.03	0.01	0.99	FALSE
15	GTEx	Esophagus Muscularis	C16orf13	0.23	0.24	lasso	4	0.22	2.8e-13	4.9	5.2	2.4e-07	0.04	0.03	0.97	FALSE
16	GTEx	Heart Atrial Appendage	WDR90	0.13	0.10	lasso	3	0.11	1.7e-05	4.9	5.5	4.2e-08	0.04	0.03	0.96	FALSE
17	GTEx	Heart Left Ventricle	C16orf13	0.10	0.08	lasso	3	0.09	1.6e-05	4.9	5.1	2.7e-07	0.03	0.02	0.96	FALSE
18	GTEx	Muscle Skeletal	C16orf13	0.05	0.02	lasso	6	0.02	3.5e-03	5.1	5.4	5.9e-08	0.00	0.03	0.95	FALSE
19	GTEx	Nerve Tibial	WDR24	0.13	0.07	lasso	6	0.09	8.2e-07	5.2	6.0	1.7e-09	0.05	0.01	0.99	TRUE
20	GTEx	Nerve Tibial	LA16c-313D11.12	0.10	0.03	lasso	6	0.03	2.6e-03	5.2	5.3	9.9e-08	0.02	0.01	0.99	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	WDR90	0.26	0.03	lasso	9	0.05	9.5e-04	5.1	5.3	1.4e-07	0.07	0.02	0.94	FALSE
22	GTEx	Skin Sun Exposed Lower leg	CACNA1H	0.22	0.21	lasso	1	0.20	8.8e-17	-5.4	5.4	6.2e-08	-0.65	0.05	0.95	TRUE
23	GTEx	Testis	RHOT2	0.24	0.30	lasso	2	0.29	3.4e-13	5.1	5.1	3.1e-07	0.03	0.02	0.98	FALSE
24	GTEx	Thyroid	FBXL16	0.12	0.09	lasso	8	0.08	2.1e-06	5.2	-5.4	7.9e-08	-0.03	0.15	0.85	FALSE
25	YFS	Blood	WFIKKN1	0.04	0.05	lasso	4	0.05	5.6e-15	5.0	5.2	2.0e-07	0.02	0.07	0.92	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR90	0.01	0.00	lasso	3	0.01	6.6e-03	5.3	-5.1	2.7e-07	-0.01	0.02	0.75	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C16orf13	0.04	0.06	blup	47	0.07	5.9e-08	4.9	5.1	2.7e-07	0.01	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	WFIKKN1	0.16	0.13	blup	48	0.16	7.3e-07	4.7	5.4	6.9e-08	0.04	0.04	0.96	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	WFIKKN1	0.20	0.39	lasso	4	0.38	1.8e-42	5.0	5.1	3.0e-07	0.02	0.03	0.97	FALSE