TWAS hub - FBXL16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.529	0.0543	6.8e-14	0.192	NA	0.258	NA	0.269	1.4e-13	NA	2.4e-18	NA	3.5e-19
2	GTEx	Thyroid	0.115	0.0340	1.2e-05	0.089	NA	0.050	NA	0.075	2.4e-07	NA	1.1e-04	NA	2.1e-06
3	YFS	Blood	0.037	0.0120	7.5e-07	0.017	0.023	0.016	0.023	0.019	2.1e-06	2.9e-08	3.0e-06	2.6e-08	4.4e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Smoking Status	12.6	30.3	42.4	5.0	6.5	4.8
Ever smoked	11.3	19.9	23.1	3.8	4.7	4.8
Past tobacco smoking	10.0	18.3	22.9	-3.7	-4.3	-4.8
Average weekly champagne plus white wine intake	10.0	13.7	18.1	-3.3	-4.3	-3.4
Alcohol intake frequency.	8.4	19.4	23.3	4.8	4.0	4.4
Height	8.3	160.1	198.8	-13.0	-14.1	-10.6
Smoking status: Previous	7.9	11.8	16.9	2.9	3.2	4.1
Happiness	7.5	9.0	10.3	-2.8	-3.2	-3.0
Standing height	7.4	73.4	104.0	-8.7	-10.2	-6.3
Qualifications: None of the above	7.2	15.5	21.5	4.3	4.6	2.5
Sitting height	7.0	49.8	65.4	-7.5	-8.1	-5.3
Loud music exposure frequency	6.7	7.4	10.8	1.8	3.3	2.8
Alcohol intake versus 10 years previously	6.6	9.9	14.6	2.4	3.1	3.8
Comparative height size at age 10	6.6	36.5	49.1	-6.2	-7.0	-4.8
Number of incorrect matches in round	6.2	10.2	10.6	-3.1	-3.2	-3.3
Back pain experienced in last month	6.1	8.9	11.0	3.3	3.3	2.3
Qualifications: College or University degree	6.0	19.0	28.8	-4.5	-5.4	-2.9
Current tobacco smoking	5.8	9.5	15.3	3.1	3.9	2.0
Age at first live birth	5.8	10.3	14.6	-3.1	-3.8	-2.6
Smoking status: Current	5.3	8.4	13.5	2.9	3.7	1.8
Qualifications: A levels/AS levels or equivalent	5.2	11.5	16.3	-4.0	-3.9	-1.8
Age at First Birth	5.0	7.2	9.6	-2.9	-3.1	-1.9
Knee pain experienced in last month	4.7	7.3	11.9	2.8	3.5	1.6
Medication: Blood pressure	4.6	8.8	11.0	-2.2	-3.3	-3.2
Breastfed as a baby	4.5	5.5	6.6	-1.9	-2.6	-2.5
Gout (self-reported)	4.5	6.1	8.0	-2.8	-2.6	-1.9
Friendships satisfaction	4.2	5.2	7.6	-2.8	-2.5	-1.3
Osteoarthritis (self-reported)	4.2	5.4	7.0	2.5	2.6	1.8
Unable to work because of sickness or disability	4.2	5.5	6.4	2.5	2.5	1.9
Blood Platelet Count	4.1	47.1	59.6	5.5	7.1	7.7
Pain experienced in last month	4.1	6.9	9.9	-2.4	-3.1	-2.3
Townsend deprivation index at recruitment	4.0	5.6	7.2	2.2	2.7	2.2
Average weekly spirits intake	3.8	4.7	6.2	-2.4	-2.5	-1.5
Tense / ‘highly strung’	3.8	6.3	7.5	-2.3	-2.4	-2.7
Wears glasses or contact lenses	3.8	4.4	5.3	-1.8	-2.2	-2.3
Tinnitus: Yes, now most or all of the time	3.8	4.5	5.2	2.2	2.3	1.9
Medication: Allopurinol	3.7	5.0	5.8	-2.3	-2.4	-1.9
Pulse rate, automated reading	3.7	12.1	22.1	2.2	3.1	4.7
Medication: Lisinopril	3.6	4.6	7.0	-1.6	-2.1	-2.6
Illnesses of siblings	3.4	4.7	5.7	2.1	2.0	2.4
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.0	8.6	-2.9	-2.9	-2.0
Reaction Time	3.3	6.2	7.2	-2.2	-2.6	-2.7
Trunk predicted mass	3.3	19.1	31.6	-4.5	-5.6	-2.3
Vitamin and mineral supplements	3.2	4.3	5.0	2.2	2.2	1.7
Trunk fat-free mass	3.2	18.1	30.1	-4.4	-5.5	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.7	6.8	1.1	1.8	2.6
Fed-up feelings	3.1	5.7	7.2	2.7	2.6	1.8
Mean time to correctly identify matches	3.1	5.8	7.5	-2.0	-2.4	-2.7
Age at last live birth	3.1	4.5	5.1	-2.2	-2.3	-1.9
High blood pressure	3.0	8.2	12.1	-2.0	-2.9	-3.5
Hearing aid user	3.0	3.4	3.8	1.9	2.0	1.6
Multivitamins +/- minerals	2.9	3.6	4.5	-1.4	-2.1	-2.1
Had major operations	2.9	3.4	6.2	1.8	2.5	1.0
Whole body fat-free mass	2.9	16.7	28.2	-4.2	-5.3	-1.9
Alzheimer’s Disease (including proxy)	2.8	4.0	7.6	1.0	2.8	1.9
Commuting to job workplace: Cycle	2.8	3.4	5.3	-2.3	-2.0	-1.0
Medication: Co-codamol	2.7	3.1	5.4	2.3	1.6	1.2
Severe depression (siblings)	2.7	3.0	3.8	1.6	1.7	2.0
Comparative body size at age 10	2.7	7.4	11.3	1.9	3.4	2.7
Hypertension (Self-reported)	2.6	7.3	11.0	-1.8	-2.8	-3.3
Leg fat-free mass (right)	2.6	14.1	24.2	-4.0	-4.9	-1.6
Whole body water mass	2.6	15.0	25.7	-4.0	-5.1	-1.8
Fluid intelligence score	2.5	5.2	8.8	-2.2	-3.0	-1.4
Health satisfaction	2.5	3.3	5.3	-2.3	-1.6	-1.5
Leg predicted mass (right)	2.5	13.5	23.5	-3.8	-4.8	-1.5
Leg fat-free mass (left)	2.4	12.5	21.6	-3.6	-4.7	-1.6
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.8	5.9	2.0	2.4	1.3
Medication: Amlodipine	2.4	3.3	5.3	-0.8	-2.0	-2.3
Neck or shoulder pain in last month	2.4	3.3	4.2	1.5	2.0	1.9
Heart disease (mother)	2.4	2.9	4.7	-0.8	-1.8	-2.2
Leg predicted mass (left)	2.3	12.3	21.4	-3.6	-4.6	-1.6
Supplements: Vitamin C	2.3	2.7	4.1	-2.0	-1.6	-1.2
Diabetes diagnosed by doctor	2.3	3.8	7.7	-1.2	-1.5	-2.8
Prostate Cancer	2.2	3.1	5.2	-1.0	-1.7	-2.3
Exposure to tobacco smoke at home	2.2	2.5	4.6	1.3	2.1	1.1
High blood pressure (siblings)	2.2	3.1	3.8	-1.5	-1.9	-1.8
Arm predicted mass (right)	2.2	11.4	18.7	-3.6	-4.3	-1.6
Medication for cholesterol	2.2	3.4	5.7	1.5	1.5	2.4
Pain type(s) experienced in last month: Hip pain	2.2	2.8	5.7	1.1	2.4	1.2
Basal metabolic rate	2.2	12.1	20.4	-3.7	-4.5	-1.5
Mean Putamen Volume	2.1	2.4	3.1	1.3	1.6	1.8
Diabetes (self-reported)	2.1	3.3	4.8	-1.5	-1.6	-2.2
Father’s age at death	2.1	2.8	4.2	-1.8	-2.0	-1.1
Arm fat-free mass (right)	2.1	10.7	17.5	-3.6	-4.2	-1.4
Miserableness	2.1	3.6	4.8	1.3	2.2	2.0
Medication: Bendroflumethiazide	2.1	3.1	5.4	-1.0	-1.8	-2.3
HbA1C	2.0	2.2	2.9	1.7	1.6	1.0
Leg fat percentage (right)	2.0	7.2	12.4	2.5	3.5	1.8
Wheeze or whistling in the chest in last year	2.0	3.5	7.7	1.5	2.8	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	4.3	-1.2	-2.1	-1.2
Depressed Affect (Nagel 2018)	1.9	4.1	6.1	2.5	2.0	1.5
Lung FVC	1.9	9.9	15.4	1.4	3.5	3.9
Long-standing illness, disability or infirmity	1.9	3.0	4.9	1.1	2.2	1.7
Leg fat percentage (left)	1.9	6.8	11.6	2.3	3.4	1.9
Vascular/heart problems diagnosed by doctor	1.9	5.1	8.6	1.3	2.2	2.9
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.2	1.8	1.7	0.9
Crohns Disease (2012)	1.8	2.9	6.0	0.0	-1.6	-2.4
Falls in the last year	1.8	2.5	3.4	1.9	1.2	1.6
Illnesses of father: Heart disease	1.8	2.5	3.6	-1.1	-1.7	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	3.2	1.6	1.8	1.8
Breast cancer (self-reported)	1.8	2.2	2.8	-1.3	-1.4	-1.7
Alcohol drinker status: Previous	1.8	2.1	3.8	1.0	1.2	2.0
Maternal smoking around birth	1.7	2.5	4.6	0.8	1.5	2.1
Medication: Atenolol	1.7	2.1	4.7	-0.6	-1.1	-2.2
Hair/balding pattern: Pattern 2	1.7	2.2	3.5	-1.3	-1.9	-1.2
Forced vital capacity (FVC)	1.7	6.5	11.1	-3.3	-2.6	-1.2
Pulse rate	1.7	2.8	5.0	0.3	1.8	2.2
Number of full sisters	1.7	2.1	2.6	1.4	1.3	1.6
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	2.5	-1.6	-1.6	-1.0
Sensitivity / hurt feelings	1.6	2.7	4.0	-1.8	-2.0	-0.9
Commuting to job workplace: Walk	1.6	1.7	1.9	1.4	1.2	1.4
Arm fat-free mass (left)	1.6	8.3	13.5	-3.2	-3.7	-1.0
Fractured/broken bones in last 5 years	1.6	2.1	4.1	2.0	1.3	0.5
Ever depressed for a whole week	1.6	1.9	4.5	-2.1	-1.1	-0.0
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	2.7	1.6	1.5	1.2
Arm predicted mass (left)	1.6	7.9	13.5	-3.0	-3.7	-1.0
Diabetes (father)	1.5	1.9	3.5	1.0	1.9	1.1
Pulse wave Arterial Stiffness index	1.5	1.8	2.5	-1.1	-1.6	-1.2
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.1	0.9	1.8	1.3
Overall health rating	1.5	3.2	5.2	2.3	1.8	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.0	1.3	1.4	1.1
Pack years adult smoking proportion	1.4	2.1	2.9	1.6	1.7	1.1
Peak expiratory flow (PEF)	1.4	3.3	4.2	-2.0	-2.0	-1.3
Blood clot in the leg (DVT)	1.4	1.8	2.1	1.4	1.3	1.3
Medication: Blood pressure	1.4	2.5	4.0	-0.7	-1.8	-2.0
LDL Cholesterol	1.3	2.0	3.7	0.5	1.4	1.9
High blood pressure (mother)	1.3	1.8	3.5	-0.7	-1.2	-1.9
Worrier / anxious feelings	1.3	2.5	4.0	-2.0	-1.6	-0.8
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	7.6	-2.8	-2.3	-0.8
Forced vital capacity (FVC), Best measure	1.3	4.6	7.5	-2.7	-2.5	-0.6
Medication: Omeprazole	1.3	1.6	3.0	1.7	1.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.9	-0.2	2.0	0.7
Qualifications: nursing, teaching	1.3	2.0	3.4	-1.4	-1.8	0.7
Verbal and Numeric Reasoning (VNR)	1.2	3.0	5.6	-1.5	-2.4	-1.1
Age when periods started (menarche)	1.2	2.8	5.2	1.3	2.3	1.2
Number of operations (self-reported)	1.2	1.8	3.7	0.6	1.9	1.2
Blood Eosinophil Count	1.1	8.6	12.6	-2.2	-2.9	-3.5
Supplements: Glucosamine	1.1	1.4	2.6	0.7	1.1	1.6
Chronic bronchitis/emphysema (father)	1.1	1.3	2.8	0.6	0.9	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	5.1	-2.2	-2.2	-0.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.1	-1.8	-1.0	-0.4
Financial situation satisfaction	1.1	1.4	2.5	0.9	1.6	0.9
Alzheimer’s Disease (in mother)	1.0	1.2	2.3	0.3	1.0	1.5
BMI	1.0	6.0	9.1	2.1	2.1	3.0
Alcohol usually taken with meals	1.0	1.5	2.9	-0.4	-1.7	-1.2
Had menopause	1.0	1.2	1.7	-1.3	-1.3	-0.6
Financial difficulties in last 2 years	1.0	1.3	1.7	1.3	1.0	1.1
Weight	1.0	4.7	7.1	-2.5	-2.7	-0.8
Arm fat percentage (right)	1.0	3.9	5.3	1.6	2.3	2.0
Noisy workplace	1.0	1.3	1.9	1.4	1.3	0.6
Medication: Lansoprazole	1.0	1.1	2.0	-1.4	-0.9	-0.8
Length of working week for main job	1.0	1.2	3.1	-0.1	0.6	1.8
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.2	1.4	1.3	1.5
Shortness of breath walking on level ground	1.0	1.2	2.9	0.6	1.7	0.5
Chest pain or discomfort	1.0	1.4	2.5	0.7	1.6	1.1
Loneliness, isolation	1.0	1.4	2.2	1.5	1.1	0.9
Ever had bowel cancer screening	1.0	1.2	2.0	0.7	1.0	1.4
Schizophrenia (2018)	0.9	1.9	2.7	-1.0	-1.4	-1.6
Worry (Nagel 2018)	0.9	2.0	2.5	-1.0	-1.6	-1.6
Chronotype (morning person)	0.9	2.0	5.3	-0.6	-0.5	-2.3
Relative age of first facial hair	0.9	1.9	2.5	-1.6	-1.0	-1.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.0	-0.7	-0.7	-1.4
Body mass index (BMI)	0.9	3.8	5.0	1.5	2.0	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.0	1.3	1.7	1.1
Hip circumference	0.9	4.1	7.1	-2.7	-2.2	-0.5
Time employed in main current job	0.9	1.0	1.7	-1.3	-1.1	-0.5
HDL Cholesterol	0.8	1.3	2.4	-1.5	-1.1	-0.7
Systolic Blood Pressure	0.8	3.9	4.7	-1.9	-1.9	-2.2
Allergy or Eczema	0.8	2.2	3.5	1.1	1.9	1.4
Cardiovascular Disease	0.8	2.6	4.4	-1.2	-1.4	-2.1
Respiratory disease	0.8	1.7	3.3	0.7	1.8	1.1
Medication: Metformin	0.8	1.1	2.8	-0.2	-0.7	-1.7
Nervous feelings	0.8	1.5	2.3	-0.9	-1.2	-1.5
Pain all over the body in last month	0.8	0.8	1.8	0.2	0.8	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.7	-1.3	-0.6	-0.8
Mouth/teeth dental problems: Dentures	0.8	1.3	3.7	1.9	0.5	0.0
Asthma	0.8	1.6	2.8	0.8	1.7	1.2
Pulse wave reflection index	0.8	1.0	1.8	-0.2	-1.1	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.5	0.7	0.9	1.2
Migraine (self-reported)	0.8	1.0	2.3	-1.5	-0.7	-0.5
Arm fat percentage (left)	0.8	3.4	4.7	1.5	2.2	1.8
Asthma (self-reported)	0.8	1.6	3.1	0.9	1.8	1.0
High cholesterol (Self-reported)	0.8	1.4	2.7	-1.2	-0.3	-1.6
Medication: Atorvastatin	0.8	1.0	2.6	0.6	0.4	-1.6
Average weekly beer plus cider intake	0.8	1.1	2.2	-1.5	-0.7	-0.8
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.1	-1.6	-2.0	-0.0
Alzheimer’s Disease (in father)	0.7	0.7	1.8	0.2	1.4	0.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.4	-1.2	-0.9	-0.3
Qualifications: CSEs or equivalent	0.7	0.9	1.2	0.8	1.1	0.9
Mouth/teeth dental problems	0.7	1.0	1.2	-1.1	-0.9	-1.0
Allergy	0.7	1.6	3.0	-0.7	-1.7	-1.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.8	-1.3	-1.3	0.0
Number of full brothers	0.7	0.9	1.9	1.4	0.8	-0.4
Number of children fathered	0.7	0.7	1.4	0.1	1.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.9	-2.0	-0.9	0.0
Mother’s age at death	0.7	0.9	1.6	0.8	1.3	0.7
Age started oral contraceptive pill	0.7	0.9	1.1	-1.0	-0.7	-1.0
Heart disease (siblings)	0.7	0.8	1.8	-0.0	0.9	-1.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.8	-1.4	-0.5	-0.5
Ever had hysterectomy (womb removed)	0.6	0.6	1.4	0.4	-0.5	-1.2
Stomach or abdominal pain in last month	0.6	0.8	1.6	0.9	1.3	0.3
Number of live births	0.6	0.9	1.7	1.3	0.6	0.7
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.1	0.6	1.0	1.0
Body fat percentage	0.6	2.6	4.4	1.4	2.1	1.1
Pulse wave peak to peak time	0.6	0.7	0.8	0.6	0.9	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.0	0.8	0.8	1.0
Illnesses of father: High blood pressure	0.6	0.7	0.9	-0.9	-0.7	-1.0
Pack years of smoking	0.6	0.8	1.2	1.0	1.1	0.5
Bipolar Disorder or Schizophrenia	0.5	1.3	1.7	-1.0	-1.3	-1.0
Schizophrenia (2014)	0.5	1.0	2.5	-0.3	-0.7	-1.6
Blood Red Count	0.5	4.9	8.3	-1.5	-2.0	-2.9
Hypothyroidism (self reported)	0.5	1.0	1.5	1.0	0.8	1.2
Systolic blood pressure, automated reading	0.5	1.4	2.4	-1.1	-0.7	-1.6
Medication for hormone replacement therapy	0.5	0.6	0.9	-0.9	-0.2	-0.9
Supplements: Zinc	0.5	0.5	0.8	0.5	0.9	0.7
Impedance of leg (left)	0.5	2.5	5.6	1.4	2.4	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.7	-1.3	-0.5	-0.6
Hearing difficulty/problems with background noise	0.5	0.8	1.9	1.4	0.3	-0.6
Prospective memory result	0.5	0.6	1.5	-0.6	-0.1	-1.2
Birth weight	0.5	1.0	2.2	0.6	0.7	1.5
Illnesses of siblings: Diabetes	0.5	0.6	0.7	0.6	0.9	0.8
Irritability	0.5	0.9	1.5	-1.1	0.2	1.2
Lupus	0.4	0.6	0.9	-0.6	-0.8	-0.9
Impedance of leg (right)	0.4	2.0	4.1	1.2	2.0	-0.7
Average weekly fortified wine intake	0.4	0.5	1.3	-0.1	0.2	-1.1
Medication: Levothyroxine sodium	0.4	0.7	1.2	0.4	0.9	1.1
Hair/balding pattern: Pattern 3	0.4	0.7	1.7	1.3	0.5	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-0.6	-1.0	-0.3
Medication: Cholesterol lowering	0.4	0.6	1.8	0.2	-0.1	-1.4
Depression (self-reported)	0.4	0.5	0.8	-0.9	-0.7	-0.5
Impedance of arm (left)	0.4	2.0	3.7	-1.1	-1.1	-1.9
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.5	0.7	0.6	0.7
Exposure to tobacco smoke outside home	0.4	0.5	1.3	0.2	1.2	0.2
Emphysema/chronic bronchitis	0.4	0.4	0.8	0.2	0.9	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	0.7	0.7	0.5	0.8
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.6	0.7	0.8	0.5
Supplements: Calcium	0.4	0.4	1.0	0.4	0.3	1.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	0.0	0.0	1.0
Neuroticism (2016)	0.3	0.4	0.8	0.4	-0.9	0.4
Blood White Count	0.3	2.3	3.7	1.7	1.9	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	-0.3	0.5	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.6	0.0	0.8	0.7
Taking other prescription medications	0.3	0.5	1.0	0.5	1.0	0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.1	-0.4	-0.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.9	0.3	1.0	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.5	-0.7	-0.5	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	-0.4	0.5	0.8
Medication: Ramipril	0.3	0.3	0.7	-0.5	-0.8	-0.4
Illnesses of mother	0.3	0.4	0.9	0.2	0.4	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.5	-0.0	0.3	1.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-1.0	-0.8	-0.1
Leg fat mass (right)	0.3	1.2	1.5	0.9	1.2	1.1
Family relationship satisfaction	0.3	0.4	0.8	-0.9	-0.6	-0.2
Medication: Aspirin	0.3	0.4	0.8	0.9	0.7	-0.2
Average weekly red wine intake	0.3	0.4	0.5	0.5	0.6	0.7
Guilty feelings	0.3	0.4	1.0	-0.4	0.3	1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.7	0.7	0.1
Diastolic blood pressure, automated reading	0.3	1.0	2.3	-0.6	-0.7	-1.5
Leg fat mass (left)	0.3	1.1	1.4	0.8	1.2	1.1
Crohns Disease (2017)	0.2	0.4	0.8	-0.5	-0.4	-0.9
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	-0.8	-0.5	-0.6
Breast Cancer	0.2	0.4	1.0	-0.3	0.5	1.0
Fasting Glucose	0.2	0.2	0.3	0.6	0.4	-0.4
Primary Biliary Cirrhosis	0.2	0.3	0.6	-0.3	0.4	-0.8
Heel T-Score	0.2	1.4	2.4	1.3	1.5	0.3
Waist Hip Ratio (WHR)	0.2	0.9	1.5	1.2	0.3	-1.1
Lung FEV1/FVC ratio	0.2	0.8	2.5	1.6	-0.0	-0.1
Hand grip strength (left)	0.2	0.6	0.8	-0.9	-0.3	0.9
Number of treatments/medications taken	0.2	0.4	0.8	0.1	0.6	-0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	-0.8	-0.3	-0.3
Angina	0.2	0.2	0.3	0.5	-0.6	-0.3
Hand grip strength (right)	0.2	0.6	1.5	-0.3	0.3	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.6	0.7	0.8	0.7
Had other major operations	0.2	0.2	0.3	-0.2	0.5	0.5
Medication: Simvastatin	0.2	0.3	0.4	-0.6	-0.5	-0.5
Impedance of arm (right)	0.2	1.1	2.4	-0.7	-0.5	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.8	0.0	0.5
Headache pain in last month	0.2	0.4	1.1	0.1	1.1	-0.0
Angina (self-reported)	0.2	0.3	0.5	0.4	-0.7	-0.5
Leg pain on walking	0.2	0.2	0.4	-0.7	-0.4	-0.3
Mood swings	0.2	0.3	0.7	0.4	0.2	0.8
Eye problems/disorders: Cataract	0.2	0.3	0.6	0.8	-0.3	-0.2
Osteoporosis (self-reported)	0.2	0.2	0.4	0.4	0.6	0.4
Arm fat mass (left)	0.2	0.6	1.6	0.2	0.5	1.2
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.6	-0.5	0.4
Medication: Paracetamol	0.2	0.3	0.8	-0.2	0.2	-0.9
Alcohol drinker status: Never	0.2	0.2	0.6	0.0	-0.8	-0.4
Risk taking	0.2	0.2	0.5	-0.4	0.2	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.4	0.6	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.3	0.6	0.5	0.5
Impedance of whole body	0.2	0.9	2.6	-0.2	0.2	-1.6
Bipolar Disorder (2018)	0.1	0.1	0.2	0.0	-0.4	0.3
Neuroticism (Nagel 2018)	0.1	0.1	0.2	0.5	0.2	0.3
Rheumatoid Arthritis	0.1	0.1	0.3	0.1	-0.2	0.6
Triglycerides	0.1	0.2	0.4	0.4	0.6	-0.3
Ulcerative Colitis	0.1	0.2	0.3	0.4	0.5	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.6	0.1	-0.7
Hair Pigment	0.1	1.6	3.3	-0.9	-1.8	-0.9
Tanning	0.1	0.7	1.8	-0.1	-0.6	-1.3
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.5	-0.4	-0.3
Diabetes (mother)	0.1	0.1	0.2	0.2	0.0	-0.4
Trunk fat percentage	0.1	0.4	1.0	0.4	1.0	0.4
Relative age voice broke	0.1	0.2	0.2	0.5	-0.4	-0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.4	-0.4	0.6	0.1
Trunk fat mass	0.1	0.5	0.9	-1.0	-0.7	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	-0.6	0.4	-0.0
Heart attack	0.1	0.1	0.2	0.4	0.4	0.3
Lung cancer (father)	0.1	0.1	0.1	0.2	-0.3	-0.3
Arm fat mass (right)	0.1	0.5	1.3	0.2	0.5	1.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.4	-0.6	-0.3	-0.6
Medication: Paracetamol	0.1	0.1	0.3	-0.5	0.0	-0.1
Glaucoma (self-reported)	0.1	0.2	0.3	-0.4	-0.2	0.6
Worry too long after embarrassment	0.1	0.2	0.3	-0.6	-0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.3	0.4	0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.5	0.4	-0.0
Suffer from ‘nerves’	0.1	0.1	0.3	0.0	0.6	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	0.6	-0.2	0.2
Medication: Aspirin	0.1	0.2	0.3	0.4	0.3	-0.6
Medication: Gliclazide	0.1	0.2	0.3	-0.4	0.1	-0.6
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.3	0.5	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.4	0.3	0.4
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	-0.2	0.3
Myopia	0.1	0.1	0.2	0.5	0.2	0.1
Cholesterol lowering medication	0.1	0.2	0.3	0.4	0.4	-0.6
Depression (Nagel 2018)	0.0	0.0	0.1	-0.1	0.3	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis (UC)	0.0	0.0	0.1	-0.3	-0.1	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.0	0.0	0.1	-0.3	-0.1	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism	0.0	0.0	0.1	-0.0	-0.2	-0.2
Waist circumference	0.0	0.1	0.2	-0.4	-0.4	0.0
Neuroticism score	0.0	0.1	0.1	-0.3	-0.3	0.0
Birth weight of first child	0.0	0.0	0.0	-0.2	-0.1	-0.2
Eye problems/disorders: None of the above	0.0	0.0	0.0	-0.1	-0.1	-0.2
Medication: Ibuprofen	0.0	0.0	0.0	-0.1	-0.1	-0.1
Medication: Seretide 50 evohaler	0.0	0.1	0.1	0.1	0.4	-0.2
Whole body fat mass	0.0	0.1	0.1	-0.2	0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	-0.2	-0.3	-0.2
Mineral and other dietary supplements	0.0	0.0	0.1	-0.0	0.1	0.3

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FBXL16

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