TWAS hub - CACNA1H

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.227	0.072	2.6e-03	0.163	NA	0.114	NA	0.160	3.0e-09	NA	8.2e-07	NA	4.2e-09
2	GTEx	Skin Sun Exposed Lower leg	0.224	0.056	7.3e-05	0.214	NA	0.186	NA	0.204	1.3e-17	NA	2.6e-15	NA	8.8e-17
3	TCGA	Uterine Corpus Endometrial Carcinoma	0.531	0.116	1.5e-03	0.183	-0.005	0.073	NA	0.108	8.3e-06	0.49	4.6e-03	NA	6.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Qualifications: College or University degree	6.1	19.2	29.3	5.0	5.4	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.6	5.3	7.6	-2.6	-2.8	1.3
Emphysema/chronic bronchitis	4.5	5.0	5.8	-2.0	-2.2	-2.4
Blood Eosinophil Count	4.2	32.5	50.1	-6.8	-7.1	-0.8
Medication for cholesterol, blood pressure or diabetes	4.2	7.0	10.3	3.2	3.0	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.1	4.8	7.2	2.5	2.7	0.8
Diabetes (mother)	4.0	5.1	7.4	-2.6	-2.7	-1.0
Pulse rate	4.0	6.7	9.1	-3.0	-2.9	1.6
Overall health rating	3.9	8.3	13.8	-3.3	-3.7	-0.3
Medication: Atorvastatin	3.7	4.5	5.8	-2.4	-2.3	1.5
Angina	3.6	4.8	7.0	-2.4	-2.6	-1.2
Alcohol usually taken with meals	3.5	5.6	8.4	2.5	2.9	1.5
Mother’s age at death	3.5	4.4	7.4	2.7	2.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.0	11.2	3.1	3.4	0.6
Heart attack	3.3	4.2	6.2	-2.5	-2.3	-1.1
Angina (self-reported)	3.3	4.4	6.8	-2.3	-2.6	-1.0
Blood White Count	3.2	23.9	37.0	-5.8	-6.1	-1.1
Average weekly spirits intake	3.1	3.9	4.3	1.9	2.1	-2.0
Hair/balding pattern: Pattern 2	3.1	3.9	5.7	2.4	2.4	0.6
Chest pain or discomfort	3.1	4.5	7.5	-2.4	-2.7	0.7
Taking other prescription medications	3.0	4.6	7.3	-2.5	-2.7	0.4
Medication: Amlodipine	3.0	4.2	6.2	-2.5	-2.5	-0.3
Vascular/heart problems diagnosed by doctor	3.0	8.2	13.3	3.4	3.6	-0.0
Heart attack/myocardial infarction (self-reported)	3.0	3.9	5.5	-2.3	-2.1	-1.3
Verbal and Numeric Reasoning (VNR)	2.9	7.1	11.1	3.3	3.1	-0.5
Medication: Co-codamol	2.8	3.3	5.0	2.2	2.0	-0.9
Pulse wave peak to peak time	2.6	3.0	4.4	1.8	2.1	-1.2
Medication: Blood pressure	2.6	4.6	7.5	-2.7	-2.4	0.5
Leg fat-free mass (right)	2.6	13.8	22.0	4.7	4.4	0.1
Leg predicted mass (right)	2.6	13.7	21.7	4.7	4.4	0.1
Number of treatments/medications taken	2.5	4.6	8.4	-2.3	-2.9	-0.2
Ever highly irritable/argumentative for 2 days	2.5	3.0	4.6	2.1	2.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.1	4.7	-2.1	-2.2	-0.2
Intelligence (Savage-Jansen 2018)	2.4	7.5	11.2	3.2	3.4	0.9
Ever used hormone-replacement therapy (HRT)	2.4	3.0	4.4	-1.6	-2.1	1.5
Nervous feelings	2.4	4.6	5.4	-2.3	-2.2	1.9
Illnesses of siblings	2.4	3.4	4.1	1.7	1.7	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.7	12.9	3.2	3.6	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	3.2	-1.7	-1.8	-1.8
Wheeze or whistling in the chest in last year	2.4	4.3	6.7	-2.4	-2.6	-0.3
Medication: Cholesterol lowering	2.3	3.6	4.3	-2.1	-1.9	1.7
Cardiovascular Disease	2.2	7.1	11.0	-3.1	-3.3	0.7
Leg fat-free mass (left)	2.2	11.5	18.1	4.3	4.0	-0.1
Age at First Birth	2.1	3.0	4.5	1.9	2.1	0.8
Leg predicted mass (left)	2.1	11.1	17.7	4.2	4.0	-0.2
Worrier / anxious feelings	2.1	4.0	5.5	2.3	2.2	1.2
High blood pressure (siblings)	2.1	3.0	4.4	-2.0	-2.1	-0.7
Whole body fat-free mass	2.1	11.7	18.5	4.3	4.0	0.8
Whole body water mass	2.1	12.1	19.0	4.4	4.1	0.9
Forced vital capacity (FVC)	2.0	7.9	12.5	3.3	3.5	-0.6
Trunk fat-free mass	2.0	11.5	17.1	4.1	3.9	1.5
Forced expiratory volume in 1-second (FEV1)	2.0	6.9	11.5	3.0	3.4	-0.1
Trunk predicted mass	2.0	11.2	16.6	4.1	3.8	1.6
Standing height	2.0	20.1	29.4	5.4	5.4	1.3
Age at first live birth	2.0	3.5	9.9	0.1	0.8	3.2
Tinnitus: Yes, now most or all of the time	2.0	2.3	3.8	-1.6	-1.9	-0.7
Medication: Lisinopril	2.0	2.6	3.5	1.8	1.9	1.1
Waist Hip Ratio (WHR)	1.9	8.6	12.2	-3.5	-3.4	-1.4
Had major operations	1.9	2.2	3.6	-1.7	-1.9	-0.2
Medication for hormone replacement therapy	1.8	2.0	2.7	-1.6	-1.6	0.7
Pulse wave Arterial Stiffness index	1.8	2.1	2.9	-1.4	-1.7	1.2
Qualifications: nursing, teaching	1.8	2.8	3.6	1.7	1.9	-1.4
High cholesterol (Self-reported)	1.8	3.2	3.6	-1.8	-1.9	1.7
Commuting to job workplace: Cycle	1.8	2.2	2.9	1.4	1.7	1.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	2.3	-1.3	-1.2	-1.5
Impedance of leg (right)	1.7	8.0	12.6	-3.5	-3.4	-0.4
Mouth/teeth dental problems	1.7	2.7	4.4	2.1	1.7	-0.8
Medication: Simvastatin	1.7	2.5	3.7	-1.9	-1.9	0.7
Basal metabolic rate	1.7	9.6	15.3	3.9	3.6	0.5
Fasting Glucose	1.6	1.9	4.5	-0.9	-0.6	2.1
Commuting to job workplace: Public transport	1.6	1.9	3.2	1.6	1.8	0.0
Unable to work because of sickness or disability	1.6	2.0	2.7	-1.2	-1.6	-1.4
Supplements: Calcium	1.6	1.8	2.9	1.0	1.2	1.7
Chronotype (morning person)	1.5	3.5	5.4	-2.3	-2.2	-0.7
Chronic bronchitis/emphysema (father)	1.5	1.8	2.3	-1.3	-1.5	-1.2
Forced vital capacity (FVC), Best measure	1.5	5.6	9.3	2.7	3.1	-0.0
Number of children fathered	1.5	1.7	3.6	-0.8	-0.8	-1.9
Shortness of breath walking on level ground	1.5	1.8	2.7	-1.5	-1.6	0.7
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	2.5	1.6	1.6	-0.5
Commuting to job workplace: Walk	1.5	1.6	2.5	1.5	1.6	-0.2
Medication: Bendroflumethiazide	1.5	2.2	3.8	-2.0	-1.6	-0.4
Illnesses of father: High blood pressure	1.5	1.9	5.3	-0.3	-0.6	2.3
Height	1.4	26.0	35.8	6.0	5.9	2.8
Impedance of leg (left)	1.4	6.7	10.4	-3.2	-3.1	-0.2
Number of full brothers	1.4	1.8	2.6	-1.2	-1.2	-1.6
Illnesses of father: None of the above (group 1)	1.4	1.8	2.9	1.5	1.7	0.4
Myopia	1.4	2.1	2.2	1.4	1.5	1.5
Pack years of smoking	1.4	2.1	2.4	-1.5	-1.6	-1.2
Rheumatoid Arthritis	1.3	1.8	2.8	1.6	1.7	0.0
Hand grip strength (left)	1.3	3.3	5.6	-1.6	-1.3	2.4
High blood pressure	1.3	3.6	6.3	-2.1	-2.5	0.5
Medication: Atenolol	1.3	1.7	2.6	-1.4	-1.6	0.6
Qualifications: None of the above	1.3	2.8	5.0	-1.8	-2.2	-0.2
Arm fat-free mass (right)	1.3	6.6	10.3	3.2	2.8	1.2
Hypertension (Self-reported)	1.3	3.7	6.4	-2.1	-2.5	0.3
Number of self-reported non-cancer illnesses	1.3	2.2	3.3	-1.6	-1.8	1.0
Neuroticism	1.2	3.0	3.6	-1.5	-1.9	1.8
Systolic blood pressure, automated reading	1.2	3.5	4.5	-1.9	-2.1	-1.5
Severe depression (siblings)	1.2	1.3	2.3	1.1	1.5	-0.5
Noisy workplace	1.2	1.4	2.5	-1.3	-1.6	-0.5
Prospective memory result	1.2	1.5	2.2	-1.5	-1.5	0.3
Length of working week for main job	1.2	1.3	2.0	1.4	1.3	-0.2
Peak expiratory flow (PEF)	1.2	2.7	4.1	2.0	2.0	-0.1
Arm predicted mass (right)	1.2	5.9	9.1	3.0	2.7	1.2
Comparative height size at age 10	1.2	6.5	8.2	2.9	2.9	1.8
Age at last live birth	1.2	1.7	5.0	0.1	0.5	2.2
Illnesses of siblings: Diabetes	1.2	1.5	3.2	-0.9	-0.7	-1.8
Wears glasses or contact lenses	1.2	1.4	2.3	-1.4	-1.5	-0.2
Ever depressed for a whole week	1.2	1.5	2.5	1.6	1.3	0.4
HbA1C	1.1	1.3	2.0	1.4	1.4	0.0
Average weekly fortified wine intake	1.1	1.3	1.6	1.2	1.3	-1.0
Number of live births	1.1	1.5	3.4	-0.7	-0.8	-1.9
Leg fat percentage (right)	1.1	4.1	5.5	-2.2	-2.3	-1.5
Mouth/teeth dental problems: Loose teeth	1.1	1.4	1.8	-1.4	-0.9	-1.2
Medication for pain relief, constipation, heartburn	1.1	1.8	2.9	1.6	1.7	0.3
Suffer from ‘nerves’	1.1	1.8	1.9	-1.3	-1.4	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.0	1.2	1.4	-0.4
Lupus	1.0	1.6	2.0	1.3	1.0	-1.4
Pack years adult smoking proportion	1.0	1.5	1.5	-1.2	-1.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	2.4	-1.5	-1.5	1.4
Fluid intelligence score	1.0	2.0	3.3	1.7	1.8	-0.2
Neuroticism score	1.0	2.0	2.5	-1.3	-1.4	1.6
Birth weight of first child	1.0	1.8	2.5	-1.6	-1.4	-1.0
Medication: Omeprazole	1.0	1.2	1.6	-1.1	-1.3	-0.8
Illnesses of father: Heart disease	1.0	1.3	2.7	-0.6	-0.9	-1.6
Diabetes diagnosed by doctor	1.0	1.6	2.5	-1.6	-1.6	0.1
Smoking status: Current	1.0	1.5	3.2	-0.6	-1.0	-1.8
Ever taken oral contraceptive pill	1.0	1.1	3.2	-0.4	-0.3	-1.8
Arm fat-free mass (left)	1.0	5.1	8.2	2.9	2.5	1.0
Fractured/broken bones in last 5 years	1.0	1.2	3.6	0.1	-0.3	-1.9
Arm predicted mass (left)	1.0	5.1	8.1	2.9	2.5	0.9
Prostate Cancer	0.9	1.3	2.0	-1.4	-1.3	0.1
Systolic Blood Pressure	0.9	4.4	5.0	-2.2	-2.2	-1.9
Diabetes (father)	0.9	1.1	1.5	-1.2	-1.0	-0.9
Current tobacco smoking	0.9	1.5	2.3	-0.8	-1.2	-1.5
Maternal smoking around birth	0.9	1.3	2.0	-1.3	-1.4	0.4
Had menopause	0.9	1.1	2.3	-1.0	-1.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.0	1.3	1.7	1.0
Leg fat percentage (left)	0.9	3.4	4.9	-1.9	-2.2	-1.3
Worry (Nagel 2018)	0.8	1.8	4.9	-0.2	-0.6	2.2
Alzheimer’s Disease (in father)	0.8	0.9	2.3	-0.5	-0.3	1.5
Ovarian Cancer	0.8	1.0	1.5	-1.2	-1.1	-0.6
Hand grip strength (right)	0.8	2.2	4.8	-1.1	-0.8	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.6	-0.5	-0.7	-1.6
Serious illness, injury or assault to yourself	0.8	1.0	1.0	-1.0	-1.0	-0.9
Multivitamins +/- minerals	0.8	1.0	1.4	1.2	1.0	-0.7
Stomach or abdominal pain in last month	0.8	1.0	1.7	-1.1	-1.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.0	1.3	1.4	0.1
Medication: Ramipril	0.8	1.0	2.3	0.6	0.7	-1.5
Alcohol intake versus 10 years previously	0.8	1.2	3.0	0.8	0.2	-1.7
Father’s age at death	0.8	1.1	3.3	0.0	0.1	1.8
Breastfed as a baby	0.8	1.0	2.2	0.7	0.4	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.2	0.8	0.9	-1.5
Pulse wave reflection index	0.8	0.9	1.7	-1.0	-1.3	0.2
Body fat percentage	0.8	3.0	5.9	-1.1	-1.4	-2.4
Medication: Seretide 50 evohaler	0.8	0.9	2.3	-0.2	-0.6	1.5
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.2	-1.1	-1.0	0.6
Average weekly champagne plus white wine intake	0.8	1.0	2.6	0.3	0.6	1.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.4	0.4	0.3	1.5
Lung FEV1/FVC ratio	0.7	3.3	5.3	1.9	2.3	-0.9
Trunk fat percentage	0.7	2.7	6.9	-0.7	-0.9	-2.6
Fed-up feelings	0.7	1.3	1.6	-1.1	-1.3	-1.0
Relative age voice broke	0.7	1.1	2.0	1.4	1.2	-0.2
Had other major operations	0.7	0.8	1.2	1.1	1.0	0.6
Diabetes (self-reported)	0.7	1.1	1.8	-1.2	-1.4	-0.3
Weight	0.7	3.3	5.4	2.3	2.0	-0.6
Arm fat percentage (right)	0.7	2.7	7.8	-0.3	-0.5	-2.8
Time employed in main current job	0.7	0.8	2.4	-0.2	-0.0	1.5
Mouth/teeth dental problems: Dentures	0.7	1.2	2.0	-1.2	-1.4	0.1
Blood clot in the leg (DVT)	0.7	0.9	1.2	0.9	0.8	1.1
Worry too long after embarrassment	0.7	1.3	3.1	-0.6	-0.5	1.8
Number of full sisters	0.7	0.9	1.2	0.8	1.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.7	-1.2	-0.5	1.3
Medication: Gliclazide	0.7	0.8	0.9	-0.8	-0.8	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.2	0.9	0.8	1.1
Impedance of whole body	0.7	3.6	5.1	-2.2	-2.0	-1.2
Neuroticism (Nagel 2018)	0.6	1.4	1.6	-1.0	-1.3	1.3
Smoking Status	0.6	1.4	3.1	-0.5	-0.9	-1.8
Age when periods started (menarche)	0.6	1.5	3.1	0.8	1.0	-1.8
Sitting height	0.6	3.9	5.2	2.2	2.3	1.4
Hip circumference	0.6	2.6	3.8	1.9	1.6	-1.1
Tense / ‘highly strung’	0.6	1.0	2.9	0.4	0.1	1.7
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.2	-1.0	-1.1	-0.5
Birth weight	0.6	1.4	4.1	0.3	0.1	-2.0
Migraine (self-reported)	0.6	0.7	1.4	-0.8	-1.2	-0.3
Medication: Aspirin	0.6	0.8	1.2	-0.9	-1.1	-0.7
Ever smoked	0.6	1.0	1.4	1.2	0.9	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.2	-0.9	-1.1	0.4
Townsend deprivation index at recruitment	0.5	0.7	1.4	-0.3	-0.8	-1.2
Pain all over the body in last month	0.5	0.6	1.3	0.3	0.5	1.1
Hair/balding pattern: Pattern 4	0.5	1.1	1.2	-1.1	-1.1	1.0
Headache pain in last month	0.5	0.9	1.5	-0.9	-1.2	-0.7
Supplements: Vitamin C	0.5	0.6	1.4	0.6	0.2	-1.2
Knee pain experienced in last month	0.5	0.8	0.9	-0.9	-1.0	-0.8
Arm fat percentage (left)	0.5	1.9	5.6	-0.2	-0.4	-2.4
Mood swings	0.5	0.9	1.1	-0.7	-1.1	-1.0
Loneliness, isolation	0.5	0.8	2.0	0.3	0.5	-1.4
Friendships satisfaction	0.5	0.6	1.0	0.6	1.0	-0.7
Osteoarthritis (self-reported)	0.5	0.7	1.7	-0.7	-1.3	-0.0
Financial situation satisfaction	0.5	0.6	1.1	-0.9	-1.0	0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	0.0	-0.2	-1.3
Risk taking	0.5	0.7	1.4	-0.4	-0.8	-1.2
Diastolic blood pressure, automated reading	0.5	1.5	2.4	-1.0	-1.0	-1.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	0.3	0.1	1.3
Depressed Affect (Nagel 2018)	0.4	0.8	1.3	-1.0	-1.1	0.1
Blood Red Count	0.4	3.6	5.4	-2.3	-2.3	0.5
Heel T-Score	0.4	3.4	5.3	-1.6	-1.5	2.3
Tanning	0.4	5.0	7.3	-2.7	-2.5	1.2
Supplements: Glucosamine	0.4	0.5	0.9	0.9	0.6	0.5
Number of incorrect matches in round	0.4	0.6	1.2	-0.7	-1.1	-0.5
Hearing difficulty/problems with background noise	0.4	0.7	1.7	-0.5	-0.4	-1.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	-0.5	-0.4	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	0.3	0.6	1.1
Medication: Paracetamol	0.4	0.7	1.2	-1.1	-0.9	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	0.2	0.4	1.1
Neck or shoulder pain in last month	0.4	0.5	0.9	-0.6	-0.9	-0.6
Heart disease (mother)	0.4	0.5	0.6	0.7	0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.7	0.6	0.5	-0.8
Family relationship satisfaction	0.4	0.5	0.6	0.7	0.8	-0.7
Medication: Aspirin	0.4	0.5	0.7	-0.6	-0.8	-0.7
Smoking status: Previous	0.4	0.6	1.0	-1.0	-0.8	0.0
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.5	0.7	0.7	-0.5
Ever had bowel cancer screening	0.4	0.4	0.7	0.7	0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.3	1.0	1.1	0.3
Arm fat mass (left)	0.4	1.5	3.6	0.8	0.5	-1.9
Medication: Paracetamol	0.4	0.7	1.0	-1.0	-0.8	0.6
Irritability	0.4	0.7	1.0	-0.8	-1.0	0.7
Heart disease (siblings)	0.4	0.4	1.2	0.3	0.3	-1.1
Depression (Nagel 2018)	0.3	0.4	0.6	-0.3	-0.8	-0.8
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	0.5	0.7	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.5	-0.7	-0.5	0.7
Crohns Disease (2017)	0.3	0.6	1.1	-0.8	-1.1	0.3
Primary Biliary Cirrhosis	0.3	0.5	0.7	0.9	0.9	0.0
Respiratory disease	0.3	0.8	1.5	-0.9	-1.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.0	-0.9	-1.0	-0.2
Lung FVC	0.3	1.3	1.6	1.0	1.3	-1.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.6	-0.6	-0.7	-0.7
Trunk fat mass	0.3	1.4	3.9	0.4	0.1	-2.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	0.5	0.8	0.4
Impedance of arm (right)	0.3	1.2	3.6	-0.1	0.3	-1.9
Falls in the last year	0.3	0.4	0.6	0.8	0.5	0.5
Lung cancer (father)	0.3	0.3	0.5	0.6	0.7	-0.1
Impedance of arm (left)	0.3	1.3	3.7	-0.2	0.1	-1.9
Arm fat mass (right)	0.3	1.3	3.3	0.7	0.3	-1.8
Health satisfaction	0.3	0.3	0.8	0.4	0.3	0.9
Medication: Ibuprofen	0.3	0.4	0.7	0.8	0.6	-0.2
Whole body fat mass	0.3	1.3	3.7	0.5	0.2	-1.9
Pulse rate, automated reading	0.3	1.0	1.5	-1.2	-1.1	-0.6
Average weekly red wine intake	0.3	0.4	0.8	0.5	0.5	0.9
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.3	-0.2	0.9
Breast cancer (self-reported)	0.3	0.4	0.9	-0.4	-0.4	0.9
Asthma (self-reported)	0.3	0.6	1.2	-0.4	-0.7	1.1
Osteoporosis (self-reported)	0.3	0.4	0.7	-0.8	-0.8	0.1
Hearing aid user	0.3	0.4	0.6	-0.7	-0.8	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.7	0.6	0.0	0.8
Pain experienced in last month	0.3	0.5	0.7	0.6	0.8	-0.7
Alcohol drinker status: Previous	0.3	0.3	0.5	0.5	0.3	0.7
Irritable Bowel Disease (IBD)	0.2	0.4	1.0	-0.6	-1.0	-0.0
BMI	0.2	1.2	1.5	-0.9	-1.1	-1.2
Allergy or Eczema	0.2	0.6	0.9	1.0	0.9	-0.5
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-0.1	0.1	-0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	0.5	0.4	0.7
Vitamin and mineral supplements	0.2	0.3	0.7	-0.1	0.2	0.8
Body mass index (BMI)	0.2	0.6	1.7	-0.2	-0.5	-1.3
Waist circumference	0.2	0.9	2.3	-0.3	-0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	-0.5	-0.4	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.4	-0.4	-0.6
Asthma	0.2	0.4	0.6	-0.4	-0.6	0.8
Depression (self-reported)	0.2	0.3	0.7	0.2	-0.3	-0.9
Medication: Lansoprazole	0.2	0.3	0.7	0.1	0.4	0.8
Illnesses of mother	0.2	0.3	0.5	0.7	0.6	-0.0
Loud music exposure frequency	0.2	0.2	0.6	0.1	0.2	-0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.0	0.5	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.4	0.7	0.7	-0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.5	-0.6	0.1
Comparative body size at age 10	0.2	0.5	0.7	-0.6	-0.9	-0.7
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.4	-0.2	0.6
Leg fat mass (right)	0.2	0.9	2.4	-0.2	-0.5	-1.5
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.4	-0.7	0.2
Mineral and other dietary supplements	0.2	0.3	0.6	-0.6	-0.2	-0.8
Miserableness	0.2	0.3	0.5	-0.7	-0.6	-0.5
Average weekly beer plus cider intake	0.2	0.3	0.7	0.4	0.3	0.8
Leg fat mass (left)	0.2	0.6	1.8	0.0	-0.3	-1.3
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.1	-0.4	-0.6
Reaction Time	0.1	0.3	0.3	0.5	0.4	0.6
Mean Putamen Volume	0.1	0.2	0.4	-0.6	-0.3	0.0
Neuroticism (2016)	0.1	0.1	0.3	0.5	0.4	-0.0
Blood Platelet Count	0.1	1.3	2.2	-0.9	-1.5	-0.9
Hypothyroidism (self reported)	0.1	0.2	0.2	0.5	0.4	-0.3
Relative age of first facial hair	0.1	0.3	0.7	0.2	0.1	0.9
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	-0.2	-0.6	-0.3
Supplements: Zinc	0.1	0.1	0.2	-0.4	-0.5	0.1
Medication: Metformin	0.1	0.1	0.3	0.1	-0.0	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.2	-0.4	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	0.6	0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.4	0.2	-0.3
Happiness	0.1	0.1	0.2	-0.1	0.0	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.3	-0.2	-0.2
Glaucoma (self-reported)	0.1	0.1	0.1	-0.3	-0.3	-0.2
Gout (self-reported)	0.1	0.1	0.3	-0.1	0.0	0.6
Medication: Allopurinol	0.1	0.1	0.2	0.3	0.5	0.4
Mean time to correctly identify matches	0.1	0.2	0.4	0.6	0.4	0.0
Back pain experienced in last month	0.1	0.2	0.3	0.5	0.1	-0.5
Guilty feelings	0.1	0.2	0.4	-0.4	-0.7	-0.0
Medication: Blood pressure	0.1	0.1	0.2	0.2	-0.3	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.5	0.5	0.3
Number of operations (self-reported)	0.1	0.1	0.1	0.3	-0.0	0.4
Cholesterol lowering medication	0.1	0.1	0.2	-0.3	-0.4	-0.3
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2018)	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Breast Cancer	0.0	0.1	0.2	0.4	0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.2	0.4	0.3	0.4	-0.6
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.1	-0.1	0.4
Tinnitus: Yes, but not now, but have in the past	0.0	0.1	0.2	0.4	0.1	-0.0
Qualifications: CSEs or equivalent	0.0	0.0	0.1	-0.1	0.2	0.3
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.1	0.4	0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.2	0.3	-0.3
High blood pressure (mother)	0.0	0.0	0.1	0.0	0.0	0.3
Past tobacco smoking	0.0	0.1	0.2	-0.0	0.1	0.4
Financial difficulties in last 2 years	0.0	0.1	0.1	0.3	-0.2	0.2
Allergy	0.0	0.1	0.1	-0.2	-0.3	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	0.3	-0.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.2	-0.1	0.0
Exposure to tobacco smoke outside home	0.0	0.0	0.0	-0.1	-0.1	-0.0
Alcohol intake frequency.	0.0	0.1	0.2	0.1	-0.4	-0.1
Leg pain on walking	0.0	0.1	0.1	-0.1	-0.3	0.2
Medication for cholesterol	0.0	0.0	0.1	-0.3	-0.1	-0.1
Alcohol drinker status: Never	0.0	0.0	0.1	0.1	-0.2	0.0
Age started oral contraceptive pill	0.0	0.0	0.1	-0.1	-0.3	-0.0

Hub : Genes

CACNA1H

Models

Trait associations