Hub : Genes

RHOT2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1320 0.0480 2.8e-03 -0.003 NA 0.007 NA -0.005 5.0e-01 NA 1.3e-01 NA 8.8e-01
2 GTEx Nerve Tibial 0.1665 0.0622 2.0e-03 0.010 NA 0.009 NA 0.012 6.3e-02 NA 6.6e-02 NA 4.8e-02
3 GTEx Testis 0.2450 0.0640 4.0e-07 0.303 NA 0.267 NA 0.287 5.9e-14 NA 3.1e-12 NA 3.4e-13
4 TCGA Breast Invasive Carcinoma 0.0143 0.0094 1.7e-03 0.006 0.006 0.004 NA 0.005 2.0e-02 0.015 4.7e-02 NA 3.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.2 0.8 0.0 0.0 0.1 -0.9
Bipolar Disorder or Schizophrenia 1.6 3.8 8.2 0.0 2.9 0.6 -2.6
Depressed Affect (Nagel 2018) 0.8 1.7 3.5 0.0 -0.8 -1.9 1.7
Depression (Nagel 2018) 0.4 0.6 1.2 0.0 -1.1 -0.2 1.1
Intelligence (Savage-Jansen 2018) 0.5 1.6 5.6 0.0 -0.5 2.4 -0.7
Neuroticism (Nagel 2018) 0.2 0.5 1.8 0.0 1.4 -0.2 0.3
Schizophrenia (2018) 1.8 3.6 7.2 0.0 2.7 0.7 -2.6
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 1.9 4.1 10.7 0.0 3.3 1.7 -1.7
Alzheimer’s Disease (in mother) 0.4 0.4 1.1 0.0 -0.6 -1.1 0.5
Alzheimer’s Disease (in father) 1.9 2.1 3.5 0.0 -1.8 -1.3 1.9
Alzheimer’s Disease (including proxy) 2.2 3.2 6.0 0.0 -1.5 -2.5 2.1
Crohns Disease (2017) 0.1 0.2 0.7 0.0 0.8 0.1 -0.5
Irritable Bowel Disease (IBD) 0.1 0.3 0.8 0.0 0.9 0.2 -0.6
Ulcerative Colitis (UC) 0.0 0.0 0.0 0.0 0.2 -0.0 0.0
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 2.0 3.8 6.8 0.0 1.3 2.6 -2.6
Verbal and Numeric Reasoning (VNR) 0.8 1.9 6.3 0.0 -0.3 2.5 -1.0
Breast Cancer 1.0 2.5 7.0 0.0 -2.6 -0.4 1.7
Ovarian Cancer 0.1 0.2 0.4 0.0 0.5 0.0 -0.6
Prostate Cancer 1.8 2.6 4.2 0.0 2.0 1.7 -1.8
Age at First Birth 3.4 4.9 9.5 0.0 1.3 3.1 -2.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.5 1.8 0.0 -0.1 -1.3 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.6 0.9 1.9 0.0 0.0 1.4 -1.3
Mean Putamen Volume 1.9 2.2 3.2 0.0 -1.7 -1.8 1.7
Fasting Glucose 1.2 1.5 5.0 0.0 -2.2 -0.7 0.7
HbA1C 2.0 2.2 3.1 0.0 -1.7 -1.7 1.8
HDL Cholesterol 0.2 0.4 1.3 0.0 0.3 1.1 0.0
LDL Cholesterol 0.6 1.0 2.7 0.0 -1.1 -1.6 0.0
Lupus 0.1 0.2 0.4 0.0 -0.6 0.6 -0.2
Neuroticism (2016) 0.3 0.4 0.8 0.0 0.9 0.8 -0.3
Primary Biliary Cirrhosis 0.2 0.3 0.4 0.0 0.6 -0.6 0.6
Rheumatoid Arthritis 0.1 0.1 0.3 0.0 -0.4 -0.1 -0.5
Schizophrenia (2014) 1.2 2.7 5.7 0.0 2.4 0.2 -2.3
Triglycerides 0.1 0.1 0.3 0.0 0.5 -0.5 0.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.1 0.2 0.8 0.0 0.9 -0.1 0.2
Blood Eosinophil Count 0.9 6.6 10.5 0.0 3.2 2.6 -3.0
Blood Platelet Count 3.1 35.7 55.2 0.0 -6.4 -6.9 7.4
Blood Red Count 0.9 8.2 22.2 0.0 4.7 1.8 -2.7
Blood White Count 0.2 1.5 3.2 0.0 -0.7 -1.8 1.6
Heel T-Score 0.3 2.0 4.7 0.0 -1.3 -1.3 2.2
BMI 0.4 2.4 6.9 0.0 -1.2 -2.6 1.2
Height 7.5 145.2 219.0 0.0 13.2 13.7 -14.8
Waist Hip Ratio (WHR) 0.0 0.0 0.1 0.0 -0.1 -0.3 -0.2
Systolic Blood Pressure 0.5 2.4 4.5 0.0 1.3 1.8 -2.1
Smoking Status 7.9 18.8 39.9 0.0 -2.3 -6.3 5.5
Allergy or Eczema 1.6 4.2 11.3 0.0 -3.4 -1.6 1.7
Cardiovascular Disease 1.0 3.2 5.8 0.0 2.4 1.6 -2.2
Hypothyroidism (self reported) 0.7 1.6 4.5 0.0 -2.1 -0.5 1.3
Respiratory disease 3.7 8.3 16.6 0.0 -4.1 -1.9 3.6
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.7 0.0 0.3 0.1 0.8
Lung FEV1/FVC ratio 0.2 0.9 2.0 0.0 1.4 0.5 -1.1
Lung FVC 1.8 9.3 15.7 0.0 -2.8 -3.7 4.0
Neuroticism 0.2 0.5 2.1 0.0 1.5 0.0 0.2
Chronotype (morning person) 0.9 2.1 6.8 0.0 2.6 0.4 -1.2
Hair Pigment 0.1 3.1 7.6 0.0 1.1 1.9 -2.8
Tanning 0.2 2.1 6.8 0.0 2.6 0.4 -1.2
Hand grip strength (left) 0.1 0.3 0.6 0.0 -0.8 0.3 -0.6
Number of treatments/medications taken 0.1 0.1 0.2 0.0 0.0 -0.5 0.4
Average weekly spirits intake 2.1 2.7 5.8 0.0 1.4 2.4 -1.7
Sensitivity / hurt feelings 2.6 4.5 8.8 0.0 3.0 1.9 -2.3
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.8 0.0 -0.9 0.1 0.3
Hearing difficulty/problems: Yes 0.3 0.4 0.8 0.0 0.9 0.6 0.6
Relative age of first facial hair 0.3 0.6 1.2 0.0 1.1 0.9 -0.7
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.6 0.0 -0.3 -0.8 1.3
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.5 0.0 -0.6 0.1 1.2
Ever had hysterectomy (womb removed) 0.7 0.8 1.6 0.0 0.9 0.9 -1.3
Systolic blood pressure, automated reading 0.2 0.5 0.9 0.0 0.8 0.7 -0.9
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.1 0.0 1.0 0.7 -0.6
Angina 0.5 0.6 1.8 0.0 0.6 0.5 -1.3
Medication for hormone replacement therapy 0.2 0.2 0.5 0.0 0.7 0.5 -0.0
Vitamin and mineral supplements 1.0 1.4 4.3 0.0 0.3 -2.1 1.0
Supplements: Zinc 0.7 0.8 2.4 0.0 -1.5 -0.5 0.8
Medication: Co-codamol 1.1 1.3 4.1 0.0 0.1 -2.0 1.1
Medication: Metformin 0.6 0.8 1.9 0.0 1.4 1.1 0.1
Diabetes (father) 2.5 3.2 5.1 0.0 -2.1 -1.8 2.3
Diabetes (mother) 0.0 0.0 0.1 0.0 0.3 -0.1 0.2
Severe depression (siblings) 3.8 4.3 8.6 0.0 -2.9 -2.0 2.1
Pack years adult smoking proportion 0.4 0.6 1.9 0.0 0.2 -1.4 0.6
Impedance of leg (right) 0.4 2.0 3.5 0.0 1.0 -1.9 1.8
Leg fat-free mass (left) 2.7 14.5 29.5 0.0 3.1 4.3 -5.4
Trunk fat percentage 0.2 0.6 1.4 0.0 1.2 -1.0 0.4
Hand grip strength (right) 0.1 0.2 0.7 0.0 -0.8 -0.2 -0.3
Townsend deprivation index at recruitment 3.6 5.0 7.6 0.0 -2.4 -2.6 2.8
Current tobacco smoking 3.8 6.1 14.9 0.0 -1.3 -3.9 2.8
Average weekly fortified wine intake 0.1 0.1 0.4 0.0 0.6 0.3 -0.0
Maternal smoking around birth 2.4 3.5 8.9 0.0 -3.0 -1.6 1.6
Fed-up feelings 1.8 3.3 6.7 0.0 -1.7 -2.6 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 2.3 0.0 -1.5 -1.1 1.5
Relative age voice broke 0.6 0.9 2.5 0.0 1.6 0.6 -0.9
Taking other prescription medications 0.3 0.4 1.2 0.0 -0.1 -1.1 0.7
Age when periods started (menarche) 1.0 2.4 4.9 0.0 -2.2 -1.5 1.5
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.7 0.0 1.3 0.8 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.8 0.0 -0.7 -1.3 0.8
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 0.0 0.9 0.6 -0.7
Qualifications: CSEs or equivalent 0.8 1.1 1.9 0.0 -1.4 -1.1 1.1
Serious illness, injury or assault to yourself 0.5 0.6 1.3 0.0 -0.6 -0.9 1.1
High blood pressure 2.4 6.6 10.0 0.0 2.6 3.2 -3.1
Hayfever, allergic rhinitis or eczema 1.0 2.1 6.6 0.0 -2.6 -0.9 1.0
Multivitamins +/- minerals 1.0 1.3 3.3 0.0 0.3 1.8 -1.3
Stomach or abdominal pain in last month 1.6 1.9 3.2 0.0 -1.6 -1.8 1.4
Supplements: Glucosamine 1.9 2.5 3.7 0.0 -1.9 -1.6 1.9
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.9 0.0 -0.4 0.3 1.0
Medication: Atenolol 1.0 1.2 2.2 0.0 1.5 0.7 -1.5
Medication: Levothyroxine sodium 0.4 0.6 1.1 0.0 -1.0 -0.6 1.0
Sitting height 5.8 40.9 59.6 0.0 6.8 7.6 -7.7
Chronic bronchitis/emphysema (father) 0.6 0.8 2.3 0.0 -0.2 -1.5 0.8
High blood pressure (mother) 0.4 0.5 1.6 0.0 -0.1 1.3 -0.6
Body mass index (BMI) 0.5 2.1 5.1 0.0 -1.2 -2.3 1.3
Impedance of leg (left) 0.5 2.4 4.8 0.0 0.8 -2.2 2.0
Leg predicted mass (left) 2.7 14.3 29.1 0.0 3.1 4.3 -5.4
Trunk fat mass 0.4 1.8 4.9 0.0 2.2 0.6 -1.5
Waist circumference 0.1 0.4 1.1 0.0 0.7 0.3 -1.1
Number of incorrect matches in round 5.2 8.7 15.1 0.0 3.9 3.0 -3.3
Past tobacco smoking 5.3 9.8 18.9 0.0 2.8 4.3 -3.5
Alcohol usually taken with meals 1.8 3.0 6.5 0.0 1.2 2.0 -2.5
Nervous feelings 1.4 2.6 7.3 0.0 2.7 1.1 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.7 0.0 0.9 0.6 -0.2
Hearing difficulty/problems with background noise 0.4 0.6 2.2 0.0 -0.4 -0.2 1.5
Hair/balding pattern: Pattern 2 1.3 1.7 2.6 0.0 1.6 1.5 -1.4
Had menopause 0.5 0.6 1.7 0.0 0.4 1.3 -0.7
Had other major operations 0.7 0.8 2.0 0.0 -1.0 -0.6 1.4
Forced vital capacity (FVC) 1.2 4.5 7.3 0.0 2.3 2.3 -2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 4.2 0.0 -1.1 -2.1 1.4
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.6 0.0 1.6 -0.8 0.7
Qualifications: None of the above 4.4 9.4 18.7 0.0 -2.3 -4.3 3.7
Financial difficulties in last 2 years 0.5 0.6 1.5 0.0 -0.6 -1.2 0.8
Mouth/teeth dental problems 0.1 0.2 0.4 0.0 0.1 0.5 -0.7
Heart attack 0.3 0.4 1.1 0.0 -1.1 -0.3 0.6
Allergy 1.9 4.5 9.9 0.0 3.1 1.8 -2.2
Pain all over the body in last month 0.6 0.6 1.5 0.0 -0.4 -0.9 1.2
Diabetes (self-reported) 0.8 1.2 3.4 0.0 1.1 1.8 -0.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.4 0.0 -0.6 -0.6 0.4
Medication: Ramipril 0.6 0.7 1.6 0.0 0.9 1.3 -0.8
Medication: Simvastatin 0.1 0.1 0.5 0.0 0.7 0.3 -0.1
Fluid intelligence score 1.4 2.9 9.0 0.0 0.5 3.0 -1.6
Illnesses of siblings 2.0 2.8 5.0 0.0 -2.2 -1.6 1.9
Neuroticism score 0.6 1.2 4.4 0.0 2.1 -0.3 -0.5
Weight 1.1 5.6 10.7 0.0 2.5 2.4 -3.3
Impedance of arm (right) 0.1 0.3 0.7 0.0 0.8 0.6 0.6
Arm fat percentage (right) 0.9 3.4 6.7 0.0 -1.5 -2.6 2.2
Trunk fat-free mass 3.4 19.6 38.9 0.0 3.7 5.1 -6.2
Hip circumference 0.7 3.1 5.5 0.0 1.9 1.8 -2.3
Time employed in main current job 0.7 0.8 1.7 0.0 0.7 1.1 -1.3
Alcohol intake versus 10 years previously 3.5 5.2 7.5 0.0 -2.4 -2.7 2.7
Father’s age at death 1.0 1.3 4.0 0.0 0.5 2.0 -0.9
Worrier / anxious feelings 1.2 2.2 5.0 0.0 2.2 1.3 -1.5
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 7.6 0.0 -1.8 -2.6 2.8
Falls in the last year 0.5 0.7 2.7 0.0 -0.3 -1.6 0.4
Hair/balding pattern: Pattern 3 0.6 0.9 2.2 0.0 1.5 -0.4 -1.1
Number of live births 0.5 0.7 2.4 0.0 -1.5 -0.3 0.5
Forced expiratory volume in 1-second (FEV1) 1.0 3.5 5.8 0.0 2.1 2.0 -2.4
Pulse rate 2.4 4.0 9.3 0.0 -2.2 -1.4 3.0
Happiness 2.7 3.3 8.4 0.0 1.2 2.9 -1.8
Noisy workplace 0.5 0.6 1.3 0.0 -0.4 -1.2 0.9
Qualifications: A levels/AS levels or equivalent 1.8 4.0 12.5 0.0 -0.1 3.5 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.5 0.0 0.7 0.7 -0.5
Mouth/teeth dental problems: Dentures 0.6 1.1 3.2 0.0 1.8 -0.2 -1.1
Asthma 1.8 3.6 6.5 0.0 -2.5 -1.6 2.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.5 0.0 -1.2 1.1 -0.3
Medication: Cholesterol lowering 0.2 0.3 1.0 0.0 1.0 0.4 -0.5
Depression (self-reported) 0.7 0.8 2.3 0.0 1.5 0.6 -0.9
Medication: Lansoprazole 0.1 0.1 0.3 0.0 0.2 0.6 -0.3
Prospective memory result 0.4 0.5 1.1 0.0 0.8 0.5 -1.0
Lung cancer (father) 0.4 0.5 1.6 0.0 1.3 0.2 -0.6
Illnesses of mother 0.1 0.1 0.5 0.0 0.2 -0.7 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 4.0 0.0 1.3 1.9 -2.0
Pulse wave Arterial Stiffness index 1.8 2.0 4.3 0.0 1.4 2.1 -1.4
Impedance of arm (left) 0.3 1.3 3.4 0.0 1.8 1.3 -0.0
Arm fat mass (right) 0.0 0.1 0.5 0.0 -0.0 -0.7 0.0
Trunk predicted mass 3.5 20.3 40.1 0.0 3.8 5.2 -6.3
Standing height 7.2 71.0 110.2 0.0 8.6 10.0 -10.5
Length of working week for main job 0.7 0.8 1.3 0.0 -1.0 -1.1 1.0
Exposure to tobacco smoke at home 1.7 1.9 3.7 0.0 -0.8 -1.9 1.7
Breastfed as a baby 1.7 2.1 5.7 0.0 0.0 2.4 -1.6
Tense / ‘highly strung’ 4.3 7.1 14.4 0.0 3.8 2.4 -2.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.8 0.0 0.3 -0.1 0.9
Hair/balding pattern: Pattern 4 0.1 0.1 0.5 0.0 -0.3 0.7 -0.2
Birth weight of first child 0.2 0.3 0.7 0.0 -0.8 0.9 -0.3
Peak expiratory flow (PEF) 1.2 2.7 4.6 0.0 1.7 1.8 -2.1
Pulse wave reflection index 0.7 0.8 1.3 0.0 1.0 1.0 -1.1
Ever highly irritable/argumentative for 2 days 1.6 2.0 4.2 0.0 -0.3 -1.9 2.0
Loud music exposure frequency 8.5 9.3 14.0 0.0 -3.6 -3.2 3.7
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.5 0.0 -0.7 0.9 -1.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.6 0.0 0.2 0.8 -0.1
Blood clot in the leg (DVT) 1.5 2.0 3.7 0.0 -1.9 -1.5 1.4
Medication: Paracetamol 0.2 0.4 1.5 0.0 -1.2 -0.3 0.2
Headache pain in last month 0.5 0.9 2.0 0.0 -0.0 -1.4 1.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.4 0.0 -1.2 -0.5 1.0
Glaucoma (self-reported) 0.3 0.3 0.7 0.0 0.8 0.6 -0.5
Gout (self-reported) 2.2 3.1 7.4 0.0 1.4 2.7 -1.7
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.8 0.0 -1.7 -0.9 1.2
Medication: Amlodipine 1.7 2.3 4.5 0.0 1.1 1.9 -2.1
Medication: Ventolin 100micrograms inhaler 1.6 2.1 3.9 0.0 -2.0 -1.3 1.7
Birth weight 0.1 0.3 0.6 0.0 -0.8 -0.6 0.2
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.3 0.0 -1.1 -1.0 0.5
High blood pressure (siblings) 2.0 2.8 4.2 0.0 2.1 1.7 -2.0
Forced vital capacity (FVC), Best measure 0.9 3.1 5.4 0.0 1.5 2.2 -2.3
Body fat percentage 0.4 1.6 4.5 0.0 0.3 -2.1 1.4
Leg fat percentage (right) 1.4 5.0 13.1 0.0 -0.8 -3.6 2.5
Arm fat-free mass (right) 2.8 14.2 27.9 0.0 3.6 4.0 -5.3
Exposure to tobacco smoke outside home 1.0 1.3 2.6 0.0 -0.7 -1.6 1.4
Comparative body size at age 10 2.4 6.8 11.0 0.0 -2.5 -3.3 3.1
Number of full brothers 0.6 0.8 1.4 0.0 1.2 -1.1 0.7
Worry too long after embarrassment 0.2 0.3 1.0 0.0 1.0 0.1 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.6 0.0 0.4 -0.4 1.3
Wheeze or whistling in the chest in last year 2.4 4.2 8.9 0.0 -1.1 -3.0 2.6
Number of children fathered 0.6 0.7 1.6 0.0 -0.3 -1.3 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.8 0.0 0.5 -0.9 0.4
Age at first live birth 4.6 8.1 13.7 0.0 2.6 3.7 -3.5
Pulse wave peak to peak time 0.6 0.8 2.0 0.0 -0.8 -1.4 0.6
Health satisfaction 0.5 0.7 1.8 0.0 1.3 1.0 -0.2
Shortness of breath walking on level ground 1.4 1.7 3.7 0.0 0.2 -1.9 1.7
Qualifications: College or University degree 3.4 10.8 26.2 0.0 1.8 5.1 -3.7
Eye problems/disorders: None of the above 0.4 0.4 1.8 0.0 -1.3 -0.0 -0.1
Mouth/teeth dental problems: Loose teeth 1.3 1.5 4.2 0.0 -2.1 -0.1 1.4
Emphysema/chronic bronchitis 0.6 0.7 1.5 0.0 -0.8 -1.2 0.8
Medication for pain relief, constipation, heartburn 0.1 0.1 0.4 0.0 0.3 0.6 -0.0
Neck or shoulder pain in last month 2.2 3.2 6.1 0.0 -1.8 -1.9 2.5
Medication: Blood pressure 2.0 3.5 5.5 0.0 2.1 2.0 -2.4
Angina (self-reported) 0.7 0.9 2.4 0.0 0.9 0.6 -1.5
Migraine (self-reported) 0.3 0.3 0.9 0.0 -1.0 0.5 0.3
Medication: Ibuprofen 0.2 0.3 0.9 0.0 -1.0 0.2 0.3
Medication: Allopurinol 2.4 3.1 5.6 0.0 1.8 2.4 -1.9
Medication: Omeprazole 0.6 0.7 1.6 0.0 1.3 -1.0 -0.0
Medication: Seretide 50 evohaler 0.1 0.1 0.2 0.0 -0.4 -0.3 0.3
Mean time to correctly identify matches 1.4 2.6 6.1 0.0 1.1 2.5 -1.8
Heart disease (mother) 2.1 2.5 4.3 0.0 1.6 2.1 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 3.4 0.0 1.6 1.8 -1.9
Whole body fat mass 0.2 0.7 2.1 0.0 1.5 -0.3 -0.8
Leg fat mass (right) 0.1 0.6 1.9 0.0 0.6 -1.4 0.1
Arm predicted mass (right) 3.1 15.7 31.4 0.0 3.8 4.1 -5.6
Pulse rate, automated reading 2.7 8.6 14.8 0.0 -3.0 -3.3 3.8
Alcohol intake frequency. 4.6 10.8 16.7 0.0 -4.1 -3.2 4.0
Comparative height size at age 10 7.5 41.1 63.2 0.0 7.4 6.8 -8.0
Number of full sisters 0.7 0.8 1.8 0.0 -0.7 -1.3 1.0
Suffer from ‘nerves’ 0.6 0.9 2.4 0.0 1.6 -1.1 -0.0
Overall health rating 0.6 1.3 3.7 0.0 -0.4 -1.9 1.1
Chest pain or discomfort 1.7 2.4 4.1 0.0 -1.7 -2.0 1.7
Had major operations 2.7 3.2 6.9 0.0 -1.2 -2.6 2.1
Age at last live birth 2.0 2.8 5.6 0.0 1.4 2.4 -1.9
Family relationship satisfaction 0.0 0.0 0.1 0.0 0.2 0.2 -0.1
Leg pain on walking 0.3 0.4 1.3 0.0 1.2 0.5 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 3.9 0.0 -1.0 -2.0 1.8
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 0.0 0.1 -0.1 -0.0
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.4 0.0 0.5 1.6 -1.1
Medication: Aspirin 0.0 0.0 0.1 0.0 0.1 -0.3 0.1
Supplements: Vitamin C 0.7 0.9 1.9 0.0 -0.8 1.4 -0.9
Knee pain experienced in last month 3.7 5.8 14.1 0.0 -1.3 -3.8 2.7
Hypertension (Self-reported) 2.2 6.0 9.4 0.0 2.5 3.1 -2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.3 0.0 -0.2 -1.2 0.7
Illnesses of father: Heart disease 1.8 2.4 6.0 0.0 2.4 1.6 -1.2
Illnesses of siblings: Diabetes 0.5 0.6 1.5 0.0 -0.5 -1.2 0.7
Smoking status: Previous 3.9 5.8 9.9 0.0 -2.3 -3.1 2.9
Forced expiratory volume in 1-second (FEV1), predicted 3.3 6.9 9.8 0.0 2.8 3.1 -3.1
Whole body fat-free mass 3.3 18.7 37.3 0.0 3.6 4.9 -6.1
Leg fat-free mass (right) 2.9 15.7 31.8 0.0 3.2 4.6 -5.6
Arm fat percentage (left) 0.6 2.5 5.5 0.0 -0.9 -2.3 1.9
Average weekly red wine intake 0.0 0.1 0.2 0.0 -0.5 -0.1 0.0
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 0.0 0.2 0.0 0.1
Mood swings 0.1 0.2 0.4 0.0 0.6 -0.7 0.2
Loneliness, isolation 1.2 1.6 3.2 0.0 -1.8 -1.3 1.2
Long-standing illness, disability or infirmity 3.4 5.2 10.7 0.0 -2.5 -1.9 3.3
Ever had bowel cancer screening 0.4 0.5 1.1 0.0 -0.3 -1.1 0.7
Diabetes diagnosed by doctor 0.8 1.2 3.4 0.0 1.2 1.8 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.3 0.0 0.3 -1.1 0.6
Friendships satisfaction 1.0 1.3 3.9 0.0 0.6 2.0 -1.0
Qualifications: nursing, teaching 0.4 0.6 1.6 0.0 -0.2 1.2 -1.0
Commuting to job workplace: Walk 0.8 0.8 1.5 0.0 -1.1 -0.8 1.2
Eye problems/disorders: Cataract 0.6 0.7 2.1 0.0 1.4 0.5 -0.7
Mouth/teeth dental problems: Mouth ulcers 2.3 3.7 6.6 0.0 -2.6 -2.1 2.0
Medication for cholesterol 0.9 1.3 2.3 0.0 -1.2 -1.5 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 4.1 0.0 -0.7 -2.0 0.9
Back pain experienced in last month 3.0 4.4 10.4 0.0 -0.9 -3.2 2.5
Mineral and other dietary supplements 0.4 0.5 1.2 0.0 1.1 0.2 -0.9
Breast cancer (self-reported) 0.8 1.0 2.6 0.0 0.6 1.6 -1.0
Asthma (self-reported) 2.2 4.3 7.5 0.0 -2.7 -1.7 2.6
Osteoporosis (self-reported) 0.5 0.6 2.0 0.0 -0.3 -0.7 1.4
Osteoarthritis (self-reported) 3.9 5.1 6.9 0.0 -2.6 -2.6 2.6
Medication: Aspirin 0.1 0.1 0.4 0.0 0.6 0.2 -0.2
Medication: Gliclazide 0.6 0.7 2.0 0.0 -1.4 0.3 0.8
Illnesses of father: None of the above (group 1) 0.3 0.3 1.3 0.0 -1.1 -0.1 -0.2
Smoking status: Current 3.2 5.1 12.9 0.0 -1.0 -3.6 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.4 0.0 -0.3 0.6 0.2
Whole body water mass 3.0 17.0 34.5 0.0 3.4 4.7 -5.9
Leg predicted mass (right) 2.9 15.3 31.0 0.0 3.1 4.5 -5.6
Arm fat mass (left) 0.0 0.2 0.6 0.0 0.2 -0.8 -0.1
Number of self-reported non-cancer illnesses 0.3 0.5 1.1 0.0 -0.8 -0.4 1.1
Average weekly champagne plus white wine intake 6.3 8.6 13.9 0.0 2.8 3.6 -3.7
Miserableness 1.7 2.9 6.5 0.0 -0.6 -2.5 2.2
Guilty feelings 0.2 0.3 0.6 0.0 0.8 -0.6 0.6
Wears glasses or contact lenses 2.1 2.5 5.5 0.0 1.3 2.4 -1.6
Ever taken oral contraceptive pill 0.7 0.8 1.6 0.0 -1.2 -0.6 1.0
Hearing aid user 3.5 3.9 6.0 0.0 -2.2 -2.2 2.5
Mother’s age at death 0.9 1.1 2.9 0.0 -1.7 -0.8 1.0
Financial situation satisfaction 1.8 2.3 3.2 0.0 -1.8 -1.8 1.7
Tinnitus: Yes, now most or all of the time 3.0 3.5 7.0 0.0 -2.6 -2.1 1.6
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.0 -0.4 0.4 0.3
Eye problems/disorders: Glaucoma 0.4 0.5 0.8 0.0 0.9 0.8 -0.6
Medication: Blood pressure 3.2 6.2 10.8 0.0 2.3 3.3 -3.0
Pain type(s) experienced in last month: Hip pain 3.4 4.3 7.0 0.0 -1.7 -2.7 2.6
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.0 0.0 -0.8 -1.0 1.0
High cholesterol (Self-reported) 0.3 0.5 1.7 0.0 1.3 0.4 -0.3
Medication: Bendroflumethiazide 2.1 3.1 6.7 0.0 1.7 1.7 -2.6
Medication: Paracetamol 0.1 0.1 0.5 0.0 -0.7 -0.2 -0.0
Medication: Lisinopril 1.7 2.2 3.9 0.0 1.5 2.0 -1.7
Medication: Atorvastatin 0.3 0.4 1.5 0.0 1.2 -0.2 -0.3
Illnesses of father: High blood pressure 0.1 0.1 0.4 0.0 -0.1 0.6 -0.2
Alcohol drinker status: Never 0.2 0.2 0.6 0.0 0.3 0.5 -0.8
Ever smoked 7.0 12.3 24.5 0.0 -2.7 -4.9 4.2
Basal metabolic rate 2.6 14.2 28.8 0.0 3.3 4.2 -5.4
Leg fat percentage (left) 1.2 4.4 12.0 0.0 -0.6 -3.5 2.3
Arm fat-free mass (left) 2.0 10.4 22.3 0.0 2.9 3.3 -4.7
Number of operations (self-reported) 1.6 2.4 4.6 0.0 -1.1 -1.9 2.1
Average weekly beer plus cider intake 0.3 0.5 1.5 0.0 1.2 0.6 -0.3
Irritability 0.3 0.6 1.5 0.0 1.2 -0.6 0.6
Risk taking 0.6 0.9 1.8 0.0 -1.3 -0.6 1.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.3 0.0 -0.1 -0.5 1.2
Fractured/broken bones in last 5 years 0.6 0.7 2.4 0.0 0.3 -1.6 0.6
Age started oral contraceptive pill 0.3 0.3 0.6 0.0 0.6 0.7 -0.8
Diastolic blood pressure, automated reading 0.3 1.1 2.4 0.0 1.5 0.4 -1.3
Ever depressed for a whole week 0.2 0.3 1.0 0.0 1.0 0.4 -0.0
Unable to work because of sickness or disability 3.2 4.1 6.9 0.0 -2.0 -2.4 2.6
Commuting to job workplace: Cycle 1.1 1.3 3.7 0.0 0.9 1.9 -0.9
Myopia 0.1 0.1 0.4 0.0 0.0 -0.3 -0.6
Vascular/heart problems diagnosed by doctor 1.7 4.6 7.0 0.0 -2.3 -2.5 2.6
Cholesterol lowering medication 0.2 0.3 0.5 0.0 0.5 -0.5 0.7
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.0 0.0 0.8 -1.7 0.4
Pain experienced in last month 2.3 3.9 10.2 0.0 0.3 3.2 -2.3
Supplements: Calcium 0.3 0.4 1.0 0.0 -1.0 -0.4 0.5
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.0 0.3 -0.5 0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.9 0.0 -1.0 -0.5 0.6
Deep venous thrombosis (DVT) (self-reported) 2.5 3.2 6.5 0.0 -2.5 -1.8 1.8
Heart disease (siblings) 0.3 0.4 1.2 0.0 -0.4 -0.6 1.1
Alcohol drinker status: Previous 1.5 1.7 3.5 0.0 -1.7 -0.8 1.9
Pack years of smoking 0.1 0.2 0.5 0.0 0.3 -0.7 0.1
Impedance of whole body 0.2 1.1 4.0 0.0 2.0 -0.0 0.5
Leg fat mass (left) 0.1 0.5 1.7 0.0 0.7 -1.3 -0.0
Arm predicted mass (left) 2.1 10.8 23.1 0.0 2.9 3.4 -4.8