TWAS hub - RHOT2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1320	0.0480	2.8e-03	-0.003	NA	0.007	NA	-0.005	5.0e-01	NA	1.3e-01	NA	8.8e-01
2	GTEx	Nerve Tibial	0.1665	0.0622	2.0e-03	0.010	NA	0.009	NA	0.012	6.3e-02	NA	6.6e-02	NA	4.8e-02
3	GTEx	Testis	0.2450	0.0640	4.0e-07	0.303	NA	0.267	NA	0.287	5.9e-14	NA	3.1e-12	NA	3.4e-13
4	TCGA	Breast Invasive Carcinoma	0.0143	0.0094	1.7e-03	0.006	0.006	0.004	NA	0.005	2.0e-02	0.015	4.7e-02	NA	3.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4
Loud music exposure frequency	8.5	9.3	14.0	-3.6	-3.2	3.7
Smoking Status	7.9	18.8	39.9	-2.3	-6.3	5.5
Height	7.5	145.2	219.0	13.2	13.7	-14.8
Comparative height size at age 10	7.5	41.1	63.2	7.4	6.8	-8.0
Standing height	7.2	71.0	110.2	8.6	10.0	-10.5
Ever smoked	7.0	12.3	24.5	-2.7	-4.9	4.2
Average weekly champagne plus white wine intake	6.3	8.6	13.9	2.8	3.6	-3.7
Sitting height	5.8	40.9	59.6	6.8	7.6	-7.7
Past tobacco smoking	5.3	9.8	18.9	2.8	4.3	-3.5
Number of incorrect matches in round	5.2	8.7	15.1	3.9	3.0	-3.3
Age at first live birth	4.6	8.1	13.7	2.6	3.7	-3.5
Alcohol intake frequency.	4.6	10.8	16.7	-4.1	-3.2	4.0
Qualifications: None of the above	4.4	9.4	18.7	-2.3	-4.3	3.7
Tense / ‘highly strung’	4.3	7.1	14.4	3.8	2.4	-2.9
Smoking status: Previous	3.9	5.8	9.9	-2.3	-3.1	2.9
Osteoarthritis (self-reported)	3.9	5.1	6.9	-2.6	-2.6	2.6
Severe depression (siblings)	3.8	4.3	8.6	-2.9	-2.0	2.1
Current tobacco smoking	3.8	6.1	14.9	-1.3	-3.9	2.8
Respiratory disease	3.7	8.3	16.6	-4.1	-1.9	3.6
Knee pain experienced in last month	3.7	5.8	14.1	-1.3	-3.8	2.7
Townsend deprivation index at recruitment	3.6	5.0	7.6	-2.4	-2.6	2.8
Alcohol intake versus 10 years previously	3.5	5.2	7.5	-2.4	-2.7	2.7
Trunk predicted mass	3.5	20.3	40.1	3.8	5.2	-6.3
Hearing aid user	3.5	3.9	6.0	-2.2	-2.2	2.5
Age at First Birth	3.4	4.9	9.5	1.3	3.1	-2.9
Trunk fat-free mass	3.4	19.6	38.9	3.7	5.1	-6.2
Qualifications: College or University degree	3.4	10.8	26.2	1.8	5.1	-3.7
Long-standing illness, disability or infirmity	3.4	5.2	10.7	-2.5	-1.9	3.3
Pain type(s) experienced in last month: Hip pain	3.4	4.3	7.0	-1.7	-2.7	2.6
Forced expiratory volume in 1-second (FEV1), predicted	3.3	6.9	9.8	2.8	3.1	-3.1
Whole body fat-free mass	3.3	18.7	37.3	3.6	4.9	-6.1
Smoking status: Current	3.2	5.1	12.9	-1.0	-3.6	2.5
Medication: Blood pressure	3.2	6.2	10.8	2.3	3.3	-3.0
Unable to work because of sickness or disability	3.2	4.1	6.9	-2.0	-2.4	2.6
Blood Platelet Count	3.1	35.7	55.2	-6.4	-6.9	7.4
Arm predicted mass (right)	3.1	15.7	31.4	3.8	4.1	-5.6
Back pain experienced in last month	3.0	4.4	10.4	-0.9	-3.2	2.5
Whole body water mass	3.0	17.0	34.5	3.4	4.7	-5.9
Tinnitus: Yes, now most or all of the time	3.0	3.5	7.0	-2.6	-2.1	1.6
Leg fat-free mass (right)	2.9	15.7	31.8	3.2	4.6	-5.6
Leg predicted mass (right)	2.9	15.3	31.0	3.1	4.5	-5.6
Arm fat-free mass (right)	2.8	14.2	27.9	3.6	4.0	-5.3
Leg fat-free mass (left)	2.7	14.5	29.5	3.1	4.3	-5.4
Leg predicted mass (left)	2.7	14.3	29.1	3.1	4.3	-5.4
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	7.6	-1.8	-2.6	2.8
Happiness	2.7	3.3	8.4	1.2	2.9	-1.8
Pulse rate, automated reading	2.7	8.6	14.8	-3.0	-3.3	3.8
Had major operations	2.7	3.2	6.9	-1.2	-2.6	2.1
Sensitivity / hurt feelings	2.6	4.5	8.8	3.0	1.9	-2.3
Basal metabolic rate	2.6	14.2	28.8	3.3	4.2	-5.4
Diabetes (father)	2.5	3.2	5.1	-2.1	-1.8	2.3
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	6.5	-2.5	-1.8	1.8
Maternal smoking around birth	2.4	3.5	8.9	-3.0	-1.6	1.6
High blood pressure	2.4	6.6	10.0	2.6	3.2	-3.1
Pulse rate	2.4	4.0	9.3	-2.2	-1.4	3.0
Comparative body size at age 10	2.4	6.8	11.0	-2.5	-3.3	3.1
Wheeze or whistling in the chest in last year	2.4	4.2	8.9	-1.1	-3.0	2.6
Medication: Allopurinol	2.4	3.1	5.6	1.8	2.4	-1.9
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	6.6	-2.6	-2.1	2.0
Pain experienced in last month	2.3	3.9	10.2	0.3	3.2	-2.3
Alzheimer’s Disease (including proxy)	2.2	3.2	6.0	-1.5	-2.5	2.1
Gout (self-reported)	2.2	3.1	7.4	1.4	2.7	-1.7
Neck or shoulder pain in last month	2.2	3.2	6.1	-1.8	-1.9	2.5
Hypertension (Self-reported)	2.2	6.0	9.4	2.5	3.1	-2.9
Asthma (self-reported)	2.2	4.3	7.5	-2.7	-1.7	2.6
Average weekly spirits intake	2.1	2.7	5.8	1.4	2.4	-1.7
Heart disease (mother)	2.1	2.5	4.3	1.6	2.1	-1.8
Wears glasses or contact lenses	2.1	2.5	5.5	1.3	2.4	-1.6
Medication: Bendroflumethiazide	2.1	3.1	6.7	1.7	1.7	-2.6
Arm predicted mass (left)	2.1	10.8	23.1	2.9	3.4	-4.8
Reaction Time	2.0	3.8	6.8	1.3	2.6	-2.6
HbA1C	2.0	2.2	3.1	-1.7	-1.7	1.8
Illnesses of siblings	2.0	2.8	5.0	-2.2	-1.6	1.9
High blood pressure (siblings)	2.0	2.8	4.2	2.1	1.7	-2.0
Medication: Blood pressure	2.0	3.5	5.5	2.1	2.0	-2.4
Age at last live birth	2.0	2.8	5.6	1.4	2.4	-1.9
Arm fat-free mass (left)	2.0	10.4	22.3	2.9	3.3	-4.7
Worry (Nagel 2018)	1.9	4.1	10.7	3.3	1.7	-1.7
Alzheimer’s Disease (in father)	1.9	2.1	3.5	-1.8	-1.3	1.9
Mean Putamen Volume	1.9	2.2	3.2	-1.7	-1.8	1.7
Supplements: Glucosamine	1.9	2.5	3.7	-1.9	-1.6	1.9
Allergy	1.9	4.5	9.9	3.1	1.8	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	3.4	1.6	1.8	-1.9
Schizophrenia (2018)	1.8	3.6	7.2	2.7	0.7	-2.6
Prostate Cancer	1.8	2.6	4.2	2.0	1.7	-1.8
Lung FVC	1.8	9.3	15.7	-2.8	-3.7	4.0
Fed-up feelings	1.8	3.3	6.7	-1.7	-2.6	1.8
Alcohol usually taken with meals	1.8	3.0	6.5	1.2	2.0	-2.5
Qualifications: A levels/AS levels or equivalent	1.8	4.0	12.5	-0.1	3.5	-1.9
Asthma	1.8	3.6	6.5	-2.5	-1.6	2.4
Pulse wave Arterial Stiffness index	1.8	2.0	4.3	1.4	2.1	-1.4
Illnesses of father: Heart disease	1.8	2.4	6.0	2.4	1.6	-1.2
Financial situation satisfaction	1.8	2.3	3.2	-1.8	-1.8	1.7
Exposure to tobacco smoke at home	1.7	1.9	3.7	-0.8	-1.9	1.7
Breastfed as a baby	1.7	2.1	5.7	0.0	2.4	-1.6
Medication: Amlodipine	1.7	2.3	4.5	1.1	1.9	-2.1
Chest pain or discomfort	1.7	2.4	4.1	-1.7	-2.0	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	3.9	-1.0	-2.0	1.8
Miserableness	1.7	2.9	6.5	-0.6	-2.5	2.2
Medication: Lisinopril	1.7	2.2	3.9	1.5	2.0	-1.7
Vascular/heart problems diagnosed by doctor	1.7	4.6	7.0	-2.3	-2.5	2.6
Bipolar Disorder or Schizophrenia	1.6	3.8	8.2	2.9	0.6	-2.6
Allergy or Eczema	1.6	4.2	11.3	-3.4	-1.6	1.7
Stomach or abdominal pain in last month	1.6	1.9	3.2	-1.6	-1.8	1.4
Ever highly irritable/argumentative for 2 days	1.6	2.0	4.2	-0.3	-1.9	2.0
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.9	-2.0	-1.3	1.7
Number of operations (self-reported)	1.6	2.4	4.6	-1.1	-1.9	2.1
Blood clot in the leg (DVT)	1.5	2.0	3.7	-1.9	-1.5	1.4
Alcohol drinker status: Previous	1.5	1.7	3.5	-1.7	-0.8	1.9
Nervous feelings	1.4	2.6	7.3	2.7	1.1	-1.4
Fluid intelligence score	1.4	2.9	9.0	0.5	3.0	-1.6
Leg fat percentage (right)	1.4	5.0	13.1	-0.8	-3.6	2.5
Shortness of breath walking on level ground	1.4	1.7	3.7	0.2	-1.9	1.7
Mean time to correctly identify matches	1.4	2.6	6.1	1.1	2.5	-1.8
Hair/balding pattern: Pattern 2	1.3	1.7	2.6	1.6	1.5	-1.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	4.2	-2.1	-0.1	1.4
Fasting Glucose	1.2	1.5	5.0	-2.2	-0.7	0.7
Schizophrenia (2014)	1.2	2.7	5.7	2.4	0.2	-2.3
Forced vital capacity (FVC)	1.2	4.5	7.3	2.3	2.3	-2.7
Worrier / anxious feelings	1.2	2.2	5.0	2.2	1.3	-1.5
Peak expiratory flow (PEF)	1.2	2.7	4.6	1.7	1.8	-2.1
Loneliness, isolation	1.2	1.6	3.2	-1.8	-1.3	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.1	-0.7	-2.0	0.9
Leg fat percentage (left)	1.2	4.4	12.0	-0.6	-3.5	2.3
Medication: Co-codamol	1.1	1.3	4.1	0.1	-2.0	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.3	-1.5	-1.1	1.5
Weight	1.1	5.6	10.7	2.5	2.4	-3.3
Commuting to job workplace: Cycle	1.1	1.3	3.7	0.9	1.9	-0.9
Breast Cancer	1.0	2.5	7.0	-2.6	-0.4	1.7
Cardiovascular Disease	1.0	3.2	5.8	2.4	1.6	-2.2
Vitamin and mineral supplements	1.0	1.4	4.3	0.3	-2.1	1.0
Age when periods started (menarche)	1.0	2.4	4.9	-2.2	-1.5	1.5
Hayfever, allergic rhinitis or eczema	1.0	2.1	6.6	-2.6	-0.9	1.0
Multivitamins +/- minerals	1.0	1.3	3.3	0.3	1.8	-1.3
Medication: Atenolol	1.0	1.2	2.2	1.5	0.7	-1.5
Father’s age at death	1.0	1.3	4.0	0.5	2.0	-0.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	5.8	2.1	2.0	-2.4
Exposure to tobacco smoke outside home	1.0	1.3	2.6	-0.7	-1.6	1.4
Friendships satisfaction	1.0	1.3	3.9	0.6	2.0	-1.0
Blood Eosinophil Count	0.9	6.6	10.5	3.2	2.6	-3.0
Blood Red Count	0.9	8.2	22.2	4.7	1.8	-2.7
Chronotype (morning person)	0.9	2.1	6.8	2.6	0.4	-1.2
Arm fat percentage (right)	0.9	3.4	6.7	-1.5	-2.6	2.2
Forced vital capacity (FVC), Best measure	0.9	3.1	5.4	1.5	2.2	-2.3
Medication for cholesterol	0.9	1.3	2.3	-1.2	-1.5	1.2
Mother’s age at death	0.9	1.1	2.9	-1.7	-0.8	1.0
Depressed Affect (Nagel 2018)	0.8	1.7	3.5	-0.8	-1.9	1.7
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.3	-0.3	2.5	-1.0
Qualifications: CSEs or equivalent	0.8	1.1	1.9	-1.4	-1.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.2	-1.1	-2.1	1.4
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.6	1.6	-0.8	0.7
Diabetes (self-reported)	0.8	1.2	3.4	1.1	1.8	-0.4
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.4	0.5	1.6	-1.1
Diabetes diagnosed by doctor	0.8	1.2	3.4	1.2	1.8	-0.2
Commuting to job workplace: Walk	0.8	0.8	1.5	-1.1	-0.8	1.2
Breast cancer (self-reported)	0.8	1.0	2.6	0.6	1.6	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.0	0.8	-1.7	0.4
Hypothyroidism (self reported)	0.7	1.6	4.5	-2.1	-0.5	1.3
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	0.9	0.9	-1.3
Supplements: Zinc	0.7	0.8	2.4	-1.5	-0.5	0.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	1.3	0.8	-0.9
Had other major operations	0.7	0.8	2.0	-1.0	-0.6	1.4
Hip circumference	0.7	3.1	5.5	1.9	1.8	-2.3
Time employed in main current job	0.7	0.8	1.7	0.7	1.1	-1.3
Depression (self-reported)	0.7	0.8	2.3	1.5	0.6	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	4.0	1.3	1.9	-2.0
Length of working week for main job	0.7	0.8	1.3	-1.0	-1.1	1.0
Pulse wave reflection index	0.7	0.8	1.3	1.0	1.0	-1.1
Angina (self-reported)	0.7	0.9	2.4	0.9	0.6	-1.5
Number of full sisters	0.7	0.8	1.8	-0.7	-1.3	1.0
Supplements: Vitamin C	0.7	0.9	1.9	-0.8	1.4	-0.9
Ever taken oral contraceptive pill	0.7	0.8	1.6	-1.2	-0.6	1.0
Crohns Disease (2012)	0.6	0.9	1.9	0.0	1.4	-1.3
LDL Cholesterol	0.6	1.0	2.7	-1.1	-1.6	0.0
Medication: Metformin	0.6	0.8	1.9	1.4	1.1	0.1
Relative age voice broke	0.6	0.9	2.5	1.6	0.6	-0.9
Chronic bronchitis/emphysema (father)	0.6	0.8	2.3	-0.2	-1.5	0.8
Pain all over the body in last month	0.6	0.6	1.5	-0.4	-0.9	1.2
Medication: Ramipril	0.6	0.7	1.6	0.9	1.3	-0.8
Neuroticism score	0.6	1.2	4.4	2.1	-0.3	-0.5
Hair/balding pattern: Pattern 3	0.6	0.9	2.2	1.5	-0.4	-1.1
Mouth/teeth dental problems: Dentures	0.6	1.1	3.2	1.8	-0.2	-1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.8	-1.7	-0.9	1.2
Number of full brothers	0.6	0.8	1.4	1.2	-1.1	0.7
Number of children fathered	0.6	0.7	1.6	-0.3	-1.3	1.1
Pulse wave peak to peak time	0.6	0.8	2.0	-0.8	-1.4	0.6
Emphysema/chronic bronchitis	0.6	0.7	1.5	-0.8	-1.2	0.8
Medication: Omeprazole	0.6	0.7	1.6	1.3	-1.0	-0.0
Suffer from ‘nerves’	0.6	0.9	2.4	1.6	-1.1	-0.0
Overall health rating	0.6	1.3	3.7	-0.4	-1.9	1.1
Arm fat percentage (left)	0.6	2.5	5.5	-0.9	-2.3	1.9
Eye problems/disorders: Cataract	0.6	0.7	2.1	1.4	0.5	-0.7
Medication: Gliclazide	0.6	0.7	2.0	-1.4	0.3	0.8
Risk taking	0.6	0.9	1.8	-1.3	-0.6	1.3
Fractured/broken bones in last 5 years	0.6	0.7	2.4	0.3	-1.6	0.6
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.6	-0.5	2.4	-0.7
Systolic Blood Pressure	0.5	2.4	4.5	1.3	1.8	-2.1
Angina	0.5	0.6	1.8	0.6	0.5	-1.3
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-0.6	-0.9	1.1
Body mass index (BMI)	0.5	2.1	5.1	-1.2	-2.3	1.3
Impedance of leg (left)	0.5	2.4	4.8	0.8	-2.2	2.0
Had menopause	0.5	0.6	1.7	0.4	1.3	-0.7
Financial difficulties in last 2 years	0.5	0.6	1.5	-0.6	-1.2	0.8
Falls in the last year	0.5	0.7	2.7	-0.3	-1.6	0.4
Number of live births	0.5	0.7	2.4	-1.5	-0.3	0.5
Noisy workplace	0.5	0.6	1.3	-0.4	-1.2	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.5	-1.2	1.1	-0.3
Headache pain in last month	0.5	0.9	2.0	-0.0	-1.4	1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	-1.1	-1.0	0.5
Health satisfaction	0.5	0.7	1.8	1.3	1.0	-0.2
Illnesses of siblings: Diabetes	0.5	0.6	1.5	-0.5	-1.2	0.7
Osteoporosis (self-reported)	0.5	0.6	2.0	-0.3	-0.7	1.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.0	-0.8	-1.0	1.0
Depression (Nagel 2018)	0.4	0.6	1.2	-1.1	-0.2	1.1
Alzheimer’s Disease (in mother)	0.4	0.4	1.1	-0.6	-1.1	0.5
BMI	0.4	2.4	6.9	-1.2	-2.6	1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.6	-0.3	-0.8	1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	-0.6	0.1	1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.1	1.0	0.7	-0.6
Pack years adult smoking proportion	0.4	0.6	1.9	0.2	-1.4	0.6
Impedance of leg (right)	0.4	2.0	3.5	1.0	-1.9	1.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.9	0.6	-0.7
Medication: Levothyroxine sodium	0.4	0.6	1.1	-1.0	-0.6	1.0
High blood pressure (mother)	0.4	0.5	1.6	-0.1	1.3	-0.6
Trunk fat mass	0.4	1.8	4.9	2.2	0.6	-1.5
Hearing difficulty/problems with background noise	0.4	0.6	2.2	-0.4	-0.2	1.5
Prospective memory result	0.4	0.5	1.1	0.8	0.5	-1.0
Lung cancer (father)	0.4	0.5	1.6	1.3	0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	-0.7	0.9	-1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.4	-1.2	-0.5	1.0
Body fat percentage	0.4	1.6	4.5	0.3	-2.1	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	0.4	-0.4	1.3
Eye problems/disorders: None of the above	0.4	0.4	1.8	-1.3	-0.0	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	-0.2	-1.2	0.7
Ever had bowel cancer screening	0.4	0.5	1.1	-0.3	-1.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	0.3	-1.1	0.6
Qualifications: nursing, teaching	0.4	0.6	1.6	-0.2	1.2	-1.0
Mineral and other dietary supplements	0.4	0.5	1.2	1.1	0.2	-0.9
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	0.9	0.8	-0.6
Body Mass Index (BMI) (2010)	0.3	0.5	1.8	-0.1	-1.3	0.0
Neuroticism (2016)	0.3	0.4	0.8	0.9	0.8	-0.3
Heel T-Score	0.3	2.0	4.7	-1.3	-1.3	2.2
Hearing difficulty/problems: Yes	0.3	0.4	0.8	0.9	0.6	0.6
Relative age of first facial hair	0.3	0.6	1.2	1.1	0.9	-0.7
Taking other prescription medications	0.3	0.4	1.2	-0.1	-1.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.8	-0.7	-1.3	0.8
Heart attack	0.3	0.4	1.1	-1.1	-0.3	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.5	0.7	0.7	-0.5
Impedance of arm (left)	0.3	1.3	3.4	1.8	1.3	-0.0
Glaucoma (self-reported)	0.3	0.3	0.7	0.8	0.6	-0.5
Migraine (self-reported)	0.3	0.3	0.9	-1.0	0.5	0.3
Leg pain on walking	0.3	0.4	1.3	1.2	0.5	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.3	1.3	-1.1	-0.1	-0.2
Number of self-reported non-cancer illnesses	0.3	0.5	1.1	-0.8	-0.4	1.1
High cholesterol (Self-reported)	0.3	0.5	1.7	1.3	0.4	-0.3
Medication: Atorvastatin	0.3	0.4	1.5	1.2	-0.2	-0.3
Average weekly beer plus cider intake	0.3	0.5	1.5	1.2	0.6	-0.3
Irritability	0.3	0.6	1.5	1.2	-0.6	0.6
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.3	-0.1	-0.5	1.2
Age started oral contraceptive pill	0.3	0.3	0.6	0.6	0.7	-0.8
Diastolic blood pressure, automated reading	0.3	1.1	2.4	1.5	0.4	-1.3
Supplements: Calcium	0.3	0.4	1.0	-1.0	-0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-1.0	-0.5	0.6
Heart disease (siblings)	0.3	0.4	1.2	-0.4	-0.6	1.1
Neuroticism (Nagel 2018)	0.2	0.5	1.8	1.4	-0.2	0.3
HDL Cholesterol	0.2	0.4	1.3	0.3	1.1	0.0
Primary Biliary Cirrhosis	0.2	0.3	0.4	0.6	-0.6	0.6
Blood White Count	0.2	1.5	3.2	-0.7	-1.8	1.6
Lung FEV1/FVC ratio	0.2	0.9	2.0	1.4	0.5	-1.1
Neuroticism	0.2	0.5	2.1	1.5	0.0	0.2
Tanning	0.2	2.1	6.8	2.6	0.4	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.8	-0.9	0.1	0.3
Systolic blood pressure, automated reading	0.2	0.5	0.9	0.8	0.7	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.5	0.7	0.5	-0.0
Trunk fat percentage	0.2	0.6	1.4	1.2	-1.0	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.9	-0.4	0.3	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.9	0.6	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.6	-0.6	0.4
Medication: Cholesterol lowering	0.2	0.3	1.0	1.0	0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.8	0.3	-0.1	0.9
Birth weight of first child	0.2	0.3	0.7	-0.8	0.9	-0.3
Medication: Paracetamol	0.2	0.4	1.5	-1.2	-0.3	0.2
Worry too long after embarrassment	0.2	0.3	1.0	1.0	0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.5	-0.9	0.4
Medication: Ibuprofen	0.2	0.3	0.9	-1.0	0.2	0.3
Whole body fat mass	0.2	0.7	2.1	1.5	-0.3	-0.8
Guilty feelings	0.2	0.3	0.6	0.8	-0.6	0.6
Alcohol drinker status: Never	0.2	0.2	0.6	0.3	0.5	-0.8
Ever depressed for a whole week	0.2	0.3	1.0	1.0	0.4	-0.0
Cholesterol lowering medication	0.2	0.3	0.5	0.5	-0.5	0.7
Impedance of whole body	0.2	1.1	4.0	2.0	-0.0	0.5
Bipolar Disorder (2018)	0.1	0.2	0.8	0.0	0.1	-0.9
Crohns Disease (2017)	0.1	0.2	0.7	0.8	0.1	-0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.9	0.2	-0.6
Ovarian Cancer	0.1	0.2	0.4	0.5	0.0	-0.6
Lupus	0.1	0.2	0.4	-0.6	0.6	-0.2
Rheumatoid Arthritis	0.1	0.1	0.3	-0.4	-0.1	-0.5
Triglycerides	0.1	0.1	0.3	0.5	-0.5	0.0
Ulcerative Colitis	0.1	0.2	0.8	0.9	-0.1	0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	0.3	0.1	0.8
Hair Pigment	0.1	3.1	7.6	1.1	1.9	-2.8
Hand grip strength (left)	0.1	0.3	0.6	-0.8	0.3	-0.6
Number of treatments/medications taken	0.1	0.1	0.2	0.0	-0.5	0.4
Hand grip strength (right)	0.1	0.2	0.7	-0.8	-0.2	-0.3
Average weekly fortified wine intake	0.1	0.1	0.4	0.6	0.3	-0.0
Waist circumference	0.1	0.4	1.1	0.7	0.3	-1.1
Mouth/teeth dental problems	0.1	0.2	0.4	0.1	0.5	-0.7
Medication: Simvastatin	0.1	0.1	0.5	0.7	0.3	-0.1
Impedance of arm (right)	0.1	0.3	0.7	0.8	0.6	0.6
Medication: Lansoprazole	0.1	0.1	0.3	0.2	0.6	-0.3
Illnesses of mother	0.1	0.1	0.5	0.2	-0.7	0.1
Hair/balding pattern: Pattern 4	0.1	0.1	0.5	-0.3	0.7	-0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.6	0.2	0.8	-0.1
Birth weight	0.1	0.3	0.6	-0.8	-0.6	0.2
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.3	0.6	-0.0
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.4	-0.3	0.3
Leg fat mass (right)	0.1	0.6	1.9	0.6	-1.4	0.1
Mood swings	0.1	0.2	0.4	0.6	-0.7	0.2
Medication: Aspirin	0.1	0.1	0.4	0.6	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.4	-0.3	0.6	0.2
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	0.4	0.3
Medication: Paracetamol	0.1	0.1	0.5	-0.7	-0.2	-0.0
Illnesses of father: High blood pressure	0.1	0.1	0.4	-0.1	0.6	-0.2
Myopia	0.1	0.1	0.4	0.0	-0.3	-0.6
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.3	-0.5	0.3
Pack years of smoking	0.1	0.2	0.5	0.3	-0.7	0.1
Leg fat mass (left)	0.1	0.5	1.7	0.7	-1.3	-0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis (UC)	0.0	0.0	0.0	0.2	-0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Waist Hip Ratio (WHR)	0.0	0.0	0.1	-0.1	-0.3	-0.2
Diabetes (mother)	0.0	0.0	0.1	0.3	-0.1	0.2
Arm fat mass (right)	0.0	0.1	0.5	-0.0	-0.7	0.0
Family relationship satisfaction	0.0	0.0	0.1	0.2	0.2	-0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	-0.1	-0.0
Medication: Aspirin	0.0	0.0	0.1	0.1	-0.3	0.1
Average weekly red wine intake	0.0	0.1	0.2	-0.5	-0.1	0.0
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	0.2	0.0	0.1
Arm fat mass (left)	0.0	0.2	0.6	0.2	-0.8	-0.1

Hub : Genes

RHOT2

Models

Trait associations