Best TWAS P=1.98e-13 · Best GWAS P=2.21e-15 conditioned to 0.308
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | HYI | 0.38 | 0.09 | lasso | 9 | 0.07 | 1.6e-06 | 4.8 | 6.4 | 1.5e-10 | 0.51 | 0.99 | 0.00 | FALSE |
2 | GTEx | Artery Aorta | MED8 | 0.10 | 0.05 | enet | 13 | 0.08 | 4.6e-05 | -3.8 | -5.3 | 9.4e-08 | -0.27 | 0.87 | 0.02 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | ARTN | 0.45 | 0.36 | enet | 29 | 0.40 | 2.5e-11 | 5.7 | 6.5 | 6.1e-11 | 0.47 | 0.57 | 0.39 | FALSE |
4 | GTEx | Brain Cerebellum | ARTN | 0.47 | 0.33 | lasso | 5 | 0.43 | 6.0e-14 | 5.4 | 7.3 | 2.1e-13 | 0.70 | 0.24 | 0.75 | FALSE |
5 | GTEx | Brain Cortex | ARTN | 0.13 | 0.04 | lasso | 5 | 0.03 | 5.9e-02 | 7.2 | 6.5 | 5.7e-11 | 0.84 | 0.10 | 0.53 | FALSE |
6 | GTEx | Breast Mammary Tissue (Female) | TIE1 | 0.10 | 0.07 | enet | 10 | 0.07 | 3.5e-03 | -5.2 | 5.2 | 2.0e-07 | 0.24 | 0.17 | 0.05 | FALSE |
7 | GTEx | Breast Mammary Tissue (Female) | ST3GAL3 | 0.03 | -0.01 | lasso | 2 | 0.01 | 1.6e-01 | 6.3 | 6.3 | 2.7e-10 | 0.42 | 0.05 | 0.08 | TRUE |
8 | GTEx | Cells Transformed fibroblasts | CCDC24 | 0.07 | 0.00 | enet | 16 | 0.02 | 9.5e-03 | 6.4 | 5.4 | 8.5e-08 | 0.67 | 0.07 | 0.70 | FALSE |
9 | GTEx | Heart Left Ventricle | MED8 | 0.08 | 0.01 | lasso | 3 | 0.01 | 1.2e-01 | -6.7 | 5.9 | 3.9e-09 | 0.34 | 0.19 | 0.06 | FALSE |
10 | GTEx | Muscle Skeletal | B4GALT2 | 0.04 | 0.05 | lasso | 2 | 0.03 | 6.4e-04 | 6.1 | -5.9 | 4.2e-09 | -0.50 | 0.16 | 0.44 | FALSE |
11 | GTEx | Muscle Skeletal | ST3GAL3 | 0.10 | 0.01 | enet | 27 | 0.01 | 1.6e-02 | -6.7 | 6.1 | 9.3e-10 | 0.36 | 0.39 | 0.28 | FALSE |
12 | GTEx | Muscle Skeletal | RP11-7O11.3 | 0.05 | 0.02 | lasso | 3 | 0.02 | 7.2e-03 | 7.7 | -7.3 | 2.0e-13 | -0.64 | 0.04 | 0.74 | TRUE |
13 | GTEx | Nerve Tibial | MED8 | 0.13 | 0.07 | enet | 11 | 0.16 | 3.6e-11 | -3.8 | -6.5 | 6.3e-11 | -0.62 | 0.92 | 0.08 | TRUE |
14 | GTEx | Pancreas | HYI | 0.22 | 0.16 | enet | 9 | 0.20 | 9.7e-09 | 4.7 | 5.4 | 7.6e-08 | 0.42 | 0.97 | 0.00 | FALSE |
15 | GTEx | Stomach | HYI | 0.16 | 0.06 | lasso | 6 | 0.07 | 4.1e-04 | 4.6 | 6.2 | 6.3e-10 | 0.54 | 0.35 | 0.20 | FALSE |
16 | GTEx | Thyroid | ARTN | 0.07 | 0.04 | lasso | 3 | 0.03 | 1.2e-03 | 7.7 | 6.4 | 1.5e-10 | 0.68 | 0.06 | 0.84 | FALSE |
17 | METSIM | Adipose | ARTN | 0.05 | 0.04 | bslmm | 412 | 0.03 | 1.3e-05 | 5.8 | 7.3 | 3.4e-13 | 0.71 | 0.36 | 0.64 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | ARTN | 0.14 | 0.19 | lasso | 4 | 0.18 | 3.0e-23 | 5.8 | 5.8 | 8.6e-09 | 0.38 | 1.00 | 0.00 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | HYI | 0.35 | 0.35 | lasso | 7 | 0.36 | 8.6e-48 | 4.7 | 5.2 | 2.0e-07 | 0.38 | 1.00 | 0.00 | FALSE |
20 | YFS | Blood | CCDC24 | 0.36 | 0.43 | lasso | 7 | 0.44 | 6.5e-160 | 6.2 | 6.1 | 1.3e-09 | 0.43 | 1.00 | 0.00 | FALSE |
21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KIAA0467 | 0.07 | 0.03 | enet | 5 | 0.04 | 7.5e-05 | 4.8 | 5.5 | 3.0e-08 | 0.56 | 0.02 | 0.98 | FALSE |
22 | The Cancer Genome Atlas | Lung Adenocarcinoma | KDM4A | 0.03 | 0.02 | enet | 5 | 0.02 | 1.5e-03 | -1.7 | -5.5 | 4.2e-08 | -0.68 | 0.03 | 0.55 | FALSE |
23 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HYI | 0.26 | 0.15 | lasso | 3 | 0.13 | 3.7e-06 | 4.6 | 5.2 | 2.6e-07 | 0.32 | 0.02 | 0.94 | FALSE |
24 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ARTN | 0.08 | 0.10 | lasso | 1 | 0.08 | 3.7e-04 | 6.1 | 6.1 | 9.8e-10 | 0.45 | 0.02 | 0.78 | FALSE |
25 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PTPRF | 0.07 | 0.01 | blup | 85 | 0.04 | 1.3e-02 | 6.0 | -6.4 | 1.5e-10 | -0.89 | 0.01 | 0.87 | FALSE |
26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DPH2 | 0.03 | 0.03 | enet | 7 | 0.04 | 5.8e-05 | 5.7 | 6.8 | 1.4e-11 | 0.52 | 0.05 | 0.91 | FALSE |
27 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HYI | 0.23 | 0.08 | blup | 34 | 0.14 | 3.1e-04 | 4.7 | 5.6 | 2.4e-08 | 0.46 | 0.01 | 0.84 | FALSE |