Hub : Genes

PTPRF

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.0770 0.0360 3.9e-03 0.083 NA 0.038 NA 0.061 7.8e-07 NA 7.4e-04 NA 2.2e-05
2 GTEx Skin Sun Exposed Lower leg 0.0530 0.0290 9.9e-03 0.015 NA 0.015 NA 0.023 2.1e-02 NA 1.9e-02 NA 5.1e-03
3 ROSMAP Brain Pre-frontal Cortex 0.0459 0.0162 5.6e-05 0.012 0.042 0.022 0.039 0.019 8.2e-03 4.1e-06 6.2e-04 7.8e-06 1.4e-03
4 TCGA Pheochromocytoma and Paraganglioma 0.0700 0.0430 4.8e-03 0.013 0.038 0.001 NA 0.005 9.3e-02 1.3e-02 2.9e-01 NA 2.0e-01
5 TCGA Thyroid Carcinoma 0.0310 0.0210 6.9e-03 0.011 0.030 0.039 NA 0.033 2.5e-02 5.8e-04 9.4e-05 NA 3.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.7 1.5 -0.9 1.2 -0.1 -1.0 -0.4
Bipolar Disorder or Schizophrenia 2.3 5.5 14.8 -2.2 1.2 -2.4 -3.8 1.0
Depressed Affect (Nagel 2018) 0.2 0.4 1.4 0.5 0.3 0.3 0.6 -1.2
Depression (Nagel 2018) 0.1 0.2 0.5 -0.7 0.1 0.3 -0.7 0.0
Intelligence (Savage-Jansen 2018) 2.5 7.6 16.5 4.1 -1.6 1.0 3.8 -1.9
Neuroticism (Nagel 2018) 0.7 1.6 3.4 1.9 -1.2 0.2 1.4 -0.9
Schizophrenia (2018) 3.2 6.6 17.0 -2.0 0.5 -3.0 -4.1 1.6
Schizophrenia vs Biploar Disorder 1.2 1.6 2.9 1.5 -1.7 -1.6 -0.1 0.8
Worry (Nagel 2018) 1.9 4.0 8.6 2.9 -0.8 1.3 2.8 -1.2
Alzheimer’s Disease (in mother) 0.6 0.7 2.0 -1.4 0.6 -0.6 -1.0 0.2
Alzheimer’s Disease (in father) 1.0 1.1 1.9 -0.5 0.4 -1.4 -1.2 1.2
Alzheimer’s Disease (including proxy) 0.7 1.0 1.3 -1.1 1.0 -0.9 -1.1 0.8
Crohns Disease (2017) 1.1 2.5 3.2 -1.8 -1.1 -1.5 -1.7 1.7
Irritable Bowel Disease (IBD) 0.3 0.7 1.5 -1.2 -0.1 -0.4 -1.2 0.7
Ulcerative Colitis (UC) 0.1 0.3 0.6 0.0 0.8 0.7 -0.4 -0.4
Major Depression (MDD) 1.8 2.2 3.5 -0.8 1.9 -1.6 -1.6 1.3
Reaction Time 3.4 6.4 10.6 -2.4 -1.8 -1.6 -3.2 3.2
Verbal and Numeric Reasoning (VNR) 1.3 3.2 7.0 2.7 -1.5 0.4 2.3 -1.1
Breast Cancer 2.7 6.6 10.0 -1.9 -1.0 -3.0 -3.2 3.0
Ovarian Cancer 1.3 1.7 7.7 0.7 -2.8 0.0 0.5 0.6
Prostate Cancer 1.1 1.6 3.4 1.8 0.0 -0.1 1.6 -1.3
Age at First Birth 1.9 2.8 5.9 2.4 -1.5 1.2 1.7 -1.2
Bipolar Disorder (2011) 0.4 0.4 1.1 0.0 1.0 0.6 0.5 -0.7
Body Mass Index (BMI) (2010) 0.6 0.9 2.4 -1.5 -0.4 -0.9 -1.0 0.1
Coronary Artery Disease (CAD) 0.5 0.5 2.1 -0.4 -1.4 0.2 -0.5 0.4
Crohns Disease (2012) 2.4 3.9 6.9 -1.9 -1.2 -2.6 -2.2 1.6
Mean Putamen Volume 0.5 0.6 1.5 0.2 0.2 -0.8 -0.8 1.2
Fasting Glucose 0.7 0.8 1.9 1.4 0.0 0.7 1.1 -0.8
HbA1C 1.4 1.6 4.2 -1.4 -0.0 -0.7 -1.2 2.0
HDL Cholesterol 0.6 0.9 2.0 0.9 0.8 0.8 1.4 -0.7
LDL Cholesterol 0.6 1.0 2.8 0.7 1.7 0.1 0.5 -1.2
Lupus 0.4 0.6 1.3 -0.0 1.1 0.0 -0.8 1.0
Neuroticism (2016) 1.2 1.7 5.5 0.9 -2.3 -0.3 -0.1 1.4
Primary Biliary Cirrhosis 0.4 0.5 1.5 1.2 -0.4 -0.5 0.3 0.8
Rheumatoid Arthritis 1.4 2.0 4.5 -1.4 -0.6 -1.1 -2.1 1.3
Schizophrenia (2014) 1.6 3.6 8.1 -1.8 0.3 -2.2 -2.8 1.2
Triglycerides 0.4 0.6 1.2 -0.1 1.0 1.1 -0.2 -0.8
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.7 -0.7 0.6 0.1 -0.2 -0.9
Ulcerative Colitis 0.2 0.3 0.8 -0.4 0.9 0.6 -0.4 -0.3
Blood Eosinophil Count 1.7 13.0 17.1 -1.9 -4.0 -4.1 -3.8 3.7
Blood Platelet Count 0.6 7.4 21.2 -2.0 -4.6 -1.5 -2.5 2.0
Blood Red Count 2.4 23.5 69.4 0.7 -8.3 -4.7 -2.2 4.6
Blood White Count 0.6 4.4 18.2 1.1 -4.3 1.1 1.1 -0.5
Heel T-Score 0.1 0.7 1.5 0.7 1.1 0.4 0.3 -1.2
BMI 0.1 0.7 1.3 -0.8 -0.5 -0.8 -0.6 -1.1
Height 0.1 2.8 9.8 1.2 -3.1 0.5 0.7 1.4
Waist Hip Ratio (WHR) 0.2 0.9 2.1 -1.1 0.7 -0.2 -1.4 0.9
Systolic Blood Pressure 1.6 8.2 22.7 2.7 -4.8 2.3 2.1 -1.0
Smoking Status 3.7 8.9 14.8 -3.8 3.3 -1.6 -3.7 1.7
Allergy or Eczema 1.5 3.9 11.4 0.3 1.1 2.0 1.7 -3.4
Cardiovascular Disease 0.1 0.4 1.2 0.3 -1.1 0.4 0.6 0.1
Hypothyroidism (self reported) 0.6 1.4 5.9 0.1 -2.4 -0.8 -0.2 0.8
Respiratory disease 0.2 0.4 0.7 -0.8 -0.6 0.2 -0.8 0.3
Type 2 Diabetes (T2D) (2018) 1.3 2.5 5.7 1.3 0.5 1.1 1.8 -2.4
Lung FEV1/FVC ratio 0.1 0.6 1.8 -1.0 -0.4 0.0 0.1 -1.3
Lung FVC 0.2 1.2 5.7 -0.2 -2.4 -0.4 -0.2 0.3
Neuroticism 0.8 1.9 5.9 2.4 -1.2 0.1 1.4 -0.1
Chronotype (morning person) 0.5 1.2 2.7 1.1 -1.7 -0.6 0.7 1.0
Hair Pigment 0.0 0.5 1.5 0.6 0.3 0.5 0.4 -1.2
Tanning 0.7 8.9 14.4 -2.3 -1.4 -3.5 -3.8 3.3
Hand grip strength (left) 0.3 0.7 1.9 -0.9 -1.4 0.1 -0.3 0.8
Number of treatments/medications taken 0.3 0.6 1.7 -1.3 0.7 0.0 -0.4 -0.8
Average weekly spirits intake 7.8 9.7 17.9 -2.5 -0.9 -3.0 -3.8 4.2
Sensitivity / hurt feelings 1.6 2.8 5.2 0.3 -2.3 -1.6 -1.9 1.5
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.5 -0.5 0.4 0.2 -0.7 -0.3
Hearing difficulty/problems: Yes 0.4 0.6 1.4 -0.0 0.8 -0.8 -0.8 1.2
Relative age of first facial hair 6.2 12.7 21.4 -2.9 0.4 -4.0 -4.6 4.2
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 4.0 -2.0 -0.7 -1.8 -1.9 0.6
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.0 -0.9 -0.0 0.0 -1.0 0.6
Ever had hysterectomy (womb removed) 0.2 0.3 0.6 -0.1 0.8 -0.4 -0.2 -0.7
Systolic blood pressure, automated reading 1.5 4.3 19.2 1.4 -4.4 0.3 0.5 -0.2
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 3.8 -0.2 1.9 0.8 0.3 -1.1
Angina 0.5 0.7 2.3 -0.7 -1.5 0.2 -0.8 0.1
Medication for hormone replacement therapy 1.2 1.3 3.0 -1.1 0.7 -0.3 -1.7 1.4
Vitamin and mineral supplements 0.2 0.3 0.6 0.7 0.3 -0.1 0.8 -0.4
Supplements: Zinc 0.7 0.8 1.4 0.3 1.2 0.7 0.6 -1.2
Medication: Co-codamol 0.7 0.8 2.2 -0.4 -0.9 0.4 -0.8 1.5
Medication: Metformin 1.3 1.8 3.4 0.9 1.8 1.3 1.0 -1.5
Diabetes (father) 0.8 0.9 4.3 0.1 -2.1 -0.1 0.7 0.1
Diabetes (mother) 2.4 3.0 5.4 -1.8 -0.1 -1.8 -2.3 1.8
Severe depression (siblings) 0.3 0.3 0.6 -0.4 0.8 0.4 0.1 0.7
Pack years adult smoking proportion 1.5 2.2 3.9 -2.0 1.5 -1.0 -1.8 0.8
Impedance of leg (right) 1.5 7.2 15.4 -2.6 -0.1 -2.1 -3.0 3.9
Leg fat-free mass (left) 0.4 2.0 2.6 1.4 -1.5 1.3 1.3 -1.6
Trunk fat percentage 0.7 2.8 5.7 -2.0 -0.5 -1.7 -2.4 0.9
Hand grip strength (right) 0.7 1.9 6.1 -0.4 -2.5 -1.1 -0.7 1.2
Townsend deprivation index at recruitment 1.9 2.7 4.4 -1.9 2.1 -1.0 -2.0 0.7
Current tobacco smoking 4.5 7.3 12.0 -2.9 2.2 -2.2 -3.5 2.6
Average weekly fortified wine intake 1.4 1.7 2.7 0.8 1.1 1.6 1.4 -1.4
Maternal smoking around birth 2.4 3.4 6.2 -1.8 2.5 -0.9 -2.5 0.8
Fed-up feelings 0.4 0.8 1.2 -1.0 -0.8 -0.9 -1.1 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.2 5.6 -1.9 -0.2 -0.7 -2.4 1.1
Relative age voice broke 5.4 8.2 15.6 -2.9 0.0 -2.9 -4.0 3.0
Taking other prescription medications 0.2 0.4 0.7 -0.8 0.5 0.5 -0.3 -0.9
Age when periods started (menarche) 4.5 10.8 22.0 -4.4 1.4 -2.5 -4.7 2.0
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 -0.0 0.2 0.3 -0.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.5 -0.0 0.5 1.2 0.7 -0.9
Tinnitus: Yes, but not now, but have in the past 3.7 3.9 8.8 1.9 -0.2 1.6 3.0 -2.2
Qualifications: CSEs or equivalent 2.2 2.9 4.3 -1.2 -0.9 -2.0 -2.1 2.0
Serious illness, injury or assault to yourself 0.6 0.7 1.5 -1.1 1.2 -0.4 -0.8 0.5
High blood pressure 0.1 0.4 1.3 0.1 -1.2 0.0 -0.0 0.7
Hayfever, allergic rhinitis or eczema 1.1 2.5 8.9 -0.6 1.1 1.2 0.8 -3.0
Multivitamins +/- minerals 0.5 0.6 1.8 -1.3 0.4 -0.2 -1.1 -0.1
Stomach or abdominal pain in last month 0.3 0.4 0.8 0.9 0.4 0.8 0.7 -0.1
Supplements: Glucosamine 0.2 0.2 0.6 -0.5 -0.1 -0.2 -0.8 0.3
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.2 0.5 1.1 0.4 0.5 -0.9
Medication: Atenolol 0.3 0.3 0.8 -0.9 -0.4 0.1 0.1 -0.8
Medication: Levothyroxine sodium 0.5 0.9 3.1 -0.5 -1.8 -0.8 -0.6 0.4
Sitting height 1.6 11.2 21.0 3.9 -1.0 3.1 4.6 -3.0
Chronic bronchitis/emphysema (father) 0.6 0.7 1.7 -0.9 -0.0 -0.9 -0.6 1.3
High blood pressure (mother) 0.8 1.1 2.6 0.9 -0.1 1.6 1.4 -0.6
Body mass index (BMI) 0.2 0.7 1.3 -1.1 -0.2 -0.6 -0.9 -1.1
Impedance of leg (left) 1.4 6.6 15.8 -1.9 -0.3 -2.2 -2.9 4.0
Leg predicted mass (left) 0.3 1.9 2.5 1.3 -1.6 1.2 1.2 -1.5
Trunk fat mass 0.3 1.4 2.9 -1.4 -0.8 -1.1 -1.7 0.4
Waist circumference 0.1 0.5 1.3 -1.2 -0.1 -0.1 -0.9 -0.6
Number of incorrect matches in round 0.4 0.6 1.7 -0.8 -0.5 -0.3 -1.3 0.6
Past tobacco smoking 3.1 5.7 11.4 3.4 -1.5 2.1 3.1 -0.9
Alcohol usually taken with meals 3.6 5.8 13.1 1.7 -0.4 2.4 3.6 -2.6
Nervous feelings 1.3 2.5 6.6 2.6 -1.5 0.8 1.7 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.3 -0.4 0.3 0.8 -0.3 -1.1
Hearing difficulty/problems with background noise 1.4 2.3 4.7 -0.7 0.2 -1.5 -2.2 2.0
Hair/balding pattern: Pattern 2 0.8 1.1 2.2 1.5 0.3 0.8 1.5 -0.5
Had menopause 0.6 0.7 1.4 -1.2 -0.7 1.2 -0.5 0.2
Had other major operations 2.9 3.5 6.8 2.1 0.5 1.7 2.6 -1.9
Forced vital capacity (FVC) 0.7 2.7 12.9 0.6 -3.6 -0.0 0.5 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.2 0.3 0.4 0.9 0.6 -1.1
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 5.0 -2.2 0.9 -1.1 -1.8 1.0
Qualifications: None of the above 9.5 20.3 41.0 -5.1 0.5 -4.7 -6.4 3.5
Financial difficulties in last 2 years 2.0 2.7 8.6 -2.9 1.1 -0.3 -1.8 -0.2
Mouth/teeth dental problems 0.6 0.9 2.2 1.0 -0.6 0.4 1.5 -0.8
Heart attack 0.9 1.1 3.1 -1.8 -0.1 -0.8 -1.3 0.1
Allergy 0.9 2.1 7.3 0.4 -0.7 -1.3 -0.8 2.7
Pain all over the body in last month 0.3 0.3 0.7 -0.4 0.8 -0.6 -0.4 -0.5
Diabetes (self-reported) 2.0 3.1 6.5 1.3 1.4 1.6 1.7 -2.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.9 -1.4 0.5 -0.4 -0.8 0.2
Medication: Ramipril 0.1 0.2 0.3 0.3 0.5 -0.5 -0.2 0.5
Medication: Simvastatin 0.4 0.6 0.9 -0.8 1.0 -0.9 -0.6 0.6
Fluid intelligence score 4.0 8.3 16.3 3.5 -0.4 2.3 4.0 -2.8
Illnesses of siblings 0.2 0.3 0.9 0.7 -0.2 0.1 1.0 -0.2
Neuroticism score 0.5 1.0 2.4 0.7 -1.5 -1.0 -0.3 0.9
Weight 0.1 0.5 2.0 -0.0 -1.4 -0.0 -0.3 -0.7
Impedance of arm (right) 1.3 6.2 12.7 -2.4 -0.9 -2.2 -2.6 3.6
Arm fat percentage (right) 0.9 3.6 7.6 -2.8 -0.7 -1.8 -2.5 0.7
Trunk fat-free mass 0.5 2.6 3.6 1.9 -1.3 1.5 1.6 -1.8
Hip circumference 0.1 0.6 2.4 -0.4 -1.5 0.3 -0.0 -0.7
Time employed in main current job 1.5 1.7 6.0 1.0 -2.4 -0.8 0.3 0.9
Alcohol intake versus 10 years previously 10.2 15.3 24.0 -4.7 -0.9 -4.3 -4.9 3.4
Father’s age at death 0.5 0.7 1.4 0.8 1.2 0.7 0.8 -0.6
Worrier / anxious feelings 1.6 3.1 6.1 2.3 -1.1 1.5 2.5 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.5 0.2 0.2 -0.1 0.2 -0.7
Falls in the last year 1.1 1.4 5.0 -2.2 0.3 -0.6 -1.2 0.3
Hair/balding pattern: Pattern 3 0.6 0.9 2.2 0.4 -1.5 0.5 0.9 -0.9
Number of live births 0.4 0.6 1.4 -0.4 -0.3 -1.2 -1.1 0.2
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 12.6 0.7 -3.5 0.0 0.8 -0.3
Pulse rate 1.0 1.8 3.7 -0.8 -1.7 -1.9 -1.2 0.2
Happiness 0.7 0.8 2.3 0.3 0.0 0.7 1.1 -1.5
Noisy workplace 4.2 5.2 9.3 -2.7 0.6 -2.4 -3.0 1.9
Qualifications: A levels/AS levels or equivalent 7.4 16.5 33.8 4.3 0.3 3.6 5.8 -4.1
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 1.6 1.2 1.2 1.0 1.1 -0.4
Mouth/teeth dental problems: Dentures 5.5 9.3 18.2 -2.4 -1.5 -3.3 -4.3 3.1
Asthma 0.1 0.1 0.3 0.2 0.2 0.4 0.3 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.1 0.6 -1.1 -0.6 0.4 0.0
Medication: Cholesterol lowering 0.7 1.1 4.0 -1.0 2.0 -0.3 -0.4 -0.4
Depression (self-reported) 1.3 1.6 4.3 -1.1 2.1 -0.5 -1.4 0.3
Medication: Lansoprazole 1.2 1.4 5.3 0.8 2.3 0.6 0.3 -0.7
Prospective memory result 0.1 0.2 0.4 0.2 0.7 -0.3 -0.5 0.2
Lung cancer (father) 0.2 0.2 0.7 0.2 0.4 0.4 -0.0 -0.8
Illnesses of mother 1.0 1.2 1.8 0.8 1.1 0.9 1.3 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.7 11.5 0.9 -3.4 0.3 1.0 -0.2
Pulse wave Arterial Stiffness index 4.5 5.2 8.6 -1.7 -1.0 -2.9 -2.9 2.2
Impedance of arm (left) 0.9 4.0 10.6 -1.5 -0.9 -1.6 -1.9 3.2
Arm fat mass (right) 0.3 1.4 2.5 -1.6 -0.9 -1.0 -1.6 0.1
Trunk predicted mass 0.4 2.5 3.3 1.8 -1.4 1.4 1.5 -1.6
Standing height 0.3 3.3 7.1 2.4 -2.7 1.3 1.3 0.5
Length of working week for main job 0.9 1.0 2.4 -0.3 -0.1 0.7 1.6 -1.5
Exposure to tobacco smoke at home 0.3 0.3 0.8 -0.9 0.5 -0.1 -0.5 -0.5
Breastfed as a baby 0.6 0.8 2.0 1.4 0.6 0.5 0.9 -0.7
Tense / ‘highly strung’ 0.2 0.4 0.8 0.8 -0.9 -0.2 0.4 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.4 7.7 -0.1 2.8 1.0 0.9 -1.5
Hair/balding pattern: Pattern 4 0.5 1.1 2.9 -0.1 -1.7 0.8 1.2 -0.7
Birth weight of first child 0.2 0.4 1.1 -1.1 -0.7 -0.3 0.1 -0.2
Peak expiratory flow (PEF) 0.9 2.1 3.8 1.1 -1.7 0.9 1.9 -1.2
Pulse wave reflection index 1.5 1.8 2.5 -1.2 -1.3 -1.6 -1.5 1.1
Ever highly irritable/argumentative for 2 days 2.0 2.4 4.5 -2.1 -0.4 -1.4 -1.6 1.6
Loud music exposure frequency 1.9 2.1 5.5 -2.3 -0.7 -0.6 -1.7 1.2
Qualifications: O levels/GCSEs or equivalent 4.9 7.8 15.4 3.2 0.0 2.2 3.9 -2.9
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.8 0.6 1.3 0.7 0.4 0.3
Blood clot in the leg (DVT) 0.1 0.2 0.4 -0.2 -0.1 -0.4 -0.3 -0.7
Medication: Paracetamol 1.1 1.9 4.1 -2.0 -0.4 -1.5 -1.3 1.0
Headache pain in last month 0.1 0.2 0.5 -0.4 0.7 -0.3 0.4 -0.5
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 4.2 0.6 -2.0 -0.3 -0.2 0.8
Glaucoma (self-reported) 1.1 1.3 2.6 1.0 -0.3 1.6 1.6 -0.5
Gout (self-reported) 0.3 0.4 0.7 -0.7 -0.2 0.8 -0.8 0.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 4.1 -0.2 -2.0 -1.3 -0.5 0.8
Medication: Amlodipine 0.4 0.5 1.4 -0.1 1.2 0.9 0.6 -0.4
Medication: Ventolin 100micrograms inhaler 1.0 1.2 2.1 0.4 1.4 1.1 0.8 -1.4
Birth weight 0.2 0.5 0.8 0.9 0.7 0.5 0.8 -0.7
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.2 0.1 1.0 -1.1 -0.1 -0.1
High blood pressure (siblings) 0.6 0.8 1.7 0.5 1.0 0.8 0.6 -1.3
Forced vital capacity (FVC), Best measure 0.8 2.8 11.9 0.8 -3.5 0.4 1.1 0.1
Body fat percentage 0.9 3.7 7.4 -2.5 -0.3 -2.0 -2.7 1.0
Leg fat percentage (right) 0.9 3.4 8.4 -2.9 0.1 -1.5 -2.5 0.4
Arm fat-free mass (right) 0.6 3.0 5.1 2.3 -1.6 1.3 1.6 -1.6
Exposure to tobacco smoke outside home 0.4 0.6 2.3 -0.1 1.5 0.3 -0.6 -0.5
Comparative body size at age 10 0.1 0.2 0.9 -0.4 1.0 -0.3 -0.3 0.1
Number of full brothers 1.0 1.3 3.0 -0.4 -0.6 -1.4 -1.7 0.9
Worry too long after embarrassment 2.9 4.8 13.0 1.0 -3.6 -2.4 -0.6 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 7.0 -0.3 2.6 1.5 0.5 -0.9
Wheeze or whistling in the chest in last year 0.6 1.0 3.9 -2.0 0.7 0.7 -0.0 -0.5
Number of children fathered 0.5 0.6 1.8 0.7 -1.4 0.3 0.5 0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.3 -1.2 -0.3 -0.6 -1.5 1.4
Age at first live birth 3.4 6.0 12.5 2.4 -0.8 2.9 3.5 -1.8
Pulse wave peak to peak time 4.3 5.0 8.5 1.8 0.8 2.9 2.9 -2.1
Health satisfaction 0.8 1.0 4.6 0.2 -0.1 -0.0 0.6 -2.1
Shortness of breath walking on level ground 1.0 1.2 2.6 -1.6 -0.6 -0.8 -1.5 0.4
Qualifications: College or University degree 8.5 26.9 53.7 5.2 -0.1 5.7 7.3 -4.6
Eye problems/disorders: None of the above 0.8 1.0 1.7 -0.9 -0.6 -1.1 -1.3 0.9
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.4 0.5 0.1 -0.3 -0.4
Emphysema/chronic bronchitis 1.0 1.1 3.0 -1.4 1.7 -0.2 -0.8 -0.2
Medication for pain relief, constipation, heartburn 0.0 0.1 0.2 0.4 0.4 0.1 0.1 0.1
Neck or shoulder pain in last month 0.8 1.1 2.4 -1.5 -0.4 -0.7 -1.5 0.6
Medication: Blood pressure 0.3 0.5 1.4 -0.3 1.2 0.8 0.5 -0.5
Angina (self-reported) 0.4 0.5 2.3 -0.4 -1.5 0.1 -0.5 -0.1
Migraine (self-reported) 1.2 1.6 3.7 1.3 0.7 1.4 1.9 -0.4
Medication: Ibuprofen 0.6 0.7 2.2 0.5 -1.5 -0.9 0.3 0.4
Medication: Allopurinol 0.4 0.5 1.1 -1.0 0.2 0.8 -0.7 -0.4
Medication: Omeprazole 0.5 0.6 1.5 -1.2 0.7 0.1 -0.8 0.6
Medication: Seretide 50 evohaler 0.5 0.6 1.4 -1.2 -0.7 0.7 -0.9 0.1
Mean time to correctly identify matches 4.7 8.9 14.4 -2.8 -2.2 -2.3 -3.8 3.5
Heart disease (mother) 0.7 0.8 2.0 1.4 -1.3 -0.2 0.2 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.2 0.8 -0.2 -1.1 -0.5 0.7
Whole body fat mass 0.3 1.4 3.1 -1.4 -0.7 -1.1 -1.8 0.3
Leg fat mass (right) 0.4 1.7 3.6 -1.8 -0.5 -1.1 -1.9 0.2
Arm predicted mass (right) 0.6 3.1 5.2 2.3 -1.4 1.6 1.8 -1.7
Pulse rate, automated reading 0.5 1.6 3.7 1.1 -0.4 0.6 1.6 -1.9
Alcohol intake frequency. 1.4 3.2 6.5 -1.9 -0.1 -2.5 -2.4 0.6
Comparative height size at age 10 1.0 5.7 10.8 3.3 -2.1 2.1 2.9 0.3
Number of full sisters 0.9 1.2 1.8 -1.1 0.5 -1.3 -1.1 1.2
Suffer from ‘nerves’ 0.6 0.9 1.8 0.3 -1.3 -0.9 -0.2 1.3
Overall health rating 0.5 1.1 1.9 -1.3 1.4 -0.8 -1.1 -0.5
Chest pain or discomfort 2.7 3.9 6.2 1.6 1.6 2.5 2.3 -1.8
Had major operations 0.8 1.0 3.5 1.9 0.2 0.7 0.6 -0.6
Age at last live birth 1.8 2.6 4.3 1.4 -1.8 1.6 2.1 -0.7
Family relationship satisfaction 0.6 0.7 1.7 -0.7 1.3 -1.0 -0.1 -0.6
Leg pain on walking 0.6 0.8 1.5 -1.2 -0.6 -0.3 -1.2 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.6 -0.6 -0.3 -1.6 -1.1 1.3
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.4 0.6 -0.4 -0.3 0.1
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 5.1 2.0 -2.3 -0.3 0.5 0.2
Medication: Aspirin 0.6 0.9 1.9 -1.4 0.3 0.6 0.4 -1.3
Supplements: Vitamin C 0.3 0.3 0.6 0.7 -0.0 0.6 0.2 0.7
Knee pain experienced in last month 0.0 0.1 0.1 -0.2 -0.3 -0.2 -0.3 0.3
Hypertension (Self-reported) 0.1 0.2 0.6 0.3 -0.8 0.3 0.3 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 4.6 -0.5 2.1 0.1 0.4 -1.0
Illnesses of father: Heart disease 0.6 0.9 3.9 -0.6 -2.0 0.0 -0.1 -0.2
Illnesses of siblings: Diabetes 2.5 3.1 6.7 -2.6 1.1 -1.5 -2.0 1.0
Smoking status: Previous 2.0 3.0 7.0 -2.6 1.5 -1.0 -2.2 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.0 0.9 -1.4 0.7 0.5 0.4
Whole body fat-free mass 0.5 2.9 3.8 1.9 -1.4 1.5 1.7 -1.9
Leg fat-free mass (right) 0.6 3.0 3.8 1.9 -1.8 1.4 1.7 -1.8
Arm fat percentage (left) 0.7 3.0 6.0 -2.5 -1.0 -1.5 -2.3 0.7
Average weekly red wine intake 2.6 3.9 9.6 1.8 -0.6 2.1 3.1 -1.3
Handedness (chirality/laterality): Left-handed 1.1 1.3 3.5 1.9 0.4 1.5 0.8 0.0
Mood swings 0.2 0.4 1.2 0.5 0.5 0.2 -0.1 -1.1
Loneliness, isolation 0.2 0.3 0.7 -0.8 -0.4 -0.2 -0.8 -0.1
Long-standing illness, disability or infirmity 1.0 1.5 3.4 -0.9 -1.2 -1.9 -1.3 0.4
Ever had bowel cancer screening 1.1 1.3 3.7 0.8 0.1 0.2 1.4 -1.9
Diabetes diagnosed by doctor 0.8 1.3 3.2 0.6 1.0 0.9 1.1 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.1 -0.7 0.6 -1.0 -0.8 -0.4
Friendships satisfaction 0.1 0.1 0.2 0.0 0.4 -0.4 0.4 -0.1
Qualifications: nursing, teaching 5.8 9.1 19.8 2.9 0.9 3.0 4.4 -2.8
Commuting to job workplace: Walk 0.7 0.8 1.2 -0.8 -0.8 -0.6 -1.1 1.0
Eye problems/disorders: Cataract 0.1 0.1 0.5 -0.1 -0.2 0.2 -0.1 0.7
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.7 0.2 1.9 0.8 0.7 -1.3
Medication for cholesterol 1.0 1.5 4.2 0.3 0.8 0.9 1.4 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.3 6.0 -1.1 -0.4 -0.9 -1.8 2.5
Back pain experienced in last month 0.5 0.8 1.7 -1.3 -0.5 -0.7 -1.1 0.5
Mineral and other dietary supplements 0.5 0.7 2.7 -0.5 1.6 0.5 0.3 -0.5
Breast cancer (self-reported) 0.6 0.7 1.1 0.3 0.6 1.1 0.9 -1.1
Asthma (self-reported) 0.0 0.1 0.2 0.0 0.1 0.1 0.2 -0.5
Osteoporosis (self-reported) 0.6 0.8 2.6 1.6 -0.0 -0.5 0.8 -0.5
Osteoarthritis (self-reported) 0.4 0.5 1.5 -0.5 1.2 0.4 -0.1 -0.9
Medication: Aspirin 0.6 0.8 2.2 -1.2 0.4 0.5 0.4 -1.5
Medication: Gliclazide 0.1 0.2 0.3 -0.4 0.6 -0.5 -0.4 -0.2
Illnesses of father: None of the above (group 1) 0.8 1.0 3.3 -0.4 1.8 0.2 -0.8 0.9
Smoking status: Current 4.1 6.5 11.3 -2.7 1.8 -2.3 -3.4 2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 3.0 1.7 -1.2 0.9 1.4 -1.2
Whole body water mass 0.5 3.0 4.0 2.0 -1.4 1.5 1.8 -1.9
Leg predicted mass (right) 0.6 3.0 3.9 2.0 -1.8 1.4 1.7 -1.8
Arm fat mass (left) 0.2 1.0 1.8 -1.3 -1.0 -0.7 -1.3 -0.1
Number of self-reported non-cancer illnesses 0.0 0.1 0.3 -0.5 0.1 0.1 -0.1 -0.2
Average weekly champagne plus white wine intake 6.4 8.7 10.8 2.3 2.8 3.3 3.3 -3.0
Miserableness 1.1 1.8 3.2 1.7 0.5 1.1 1.8 -1.3
Guilty feelings 3.8 5.8 7.1 -2.0 -2.7 -2.6 -2.6 2.1
Wears glasses or contact lenses 0.5 0.6 1.6 0.8 0.4 1.3 0.7 -0.1
Ever taken oral contraceptive pill 0.3 0.3 1.2 0.4 1.1 0.2 -0.4 0.0
Hearing aid user 0.8 0.9 1.5 -1.1 -1.2 -0.6 -1.1 -0.1
Mother’s age at death 0.4 0.5 1.3 -0.4 -1.1 -1.1 -0.2 0.0
Financial situation satisfaction 0.5 0.7 1.2 0.9 -0.0 0.7 0.9 -1.1
Tinnitus: Yes, now most or all of the time 2.3 2.7 4.0 -1.3 -0.9 -2.0 -2.0 1.7
Commuting to job workplace: Public transport 1.5 1.8 3.0 1.1 -1.5 1.0 1.7 -1.3
Eye problems/disorders: Glaucoma 0.8 1.0 2.2 0.3 -0.1 1.5 1.4 -0.9
Medication: Blood pressure 0.4 0.8 2.4 1.6 -1.0 0.0 0.5 0.6
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.7 0.5 1.3 1.2 0.9 -1.0
Supplements: Fish oil (including cod liver oil) 0.7 0.9 4.1 0.5 -2.0 -0.1 0.1 0.5
High cholesterol (Self-reported) 0.3 0.5 2.6 0.0 1.6 -0.0 -0.3 -0.0
Medication: Bendroflumethiazide 0.3 0.4 0.8 0.9 -0.7 -0.7 0.4 0.5
Medication: Paracetamol 2.0 3.0 5.2 -2.3 -1.0 -1.9 -1.7 1.5
Medication: Lisinopril 0.4 0.5 1.6 1.2 -0.4 0.2 0.6 -0.5
Medication: Atorvastatin 0.3 0.4 1.3 -0.4 -1.1 0.3 -0.5 0.2
Illnesses of father: High blood pressure 1.1 1.4 3.3 1.8 -0.8 0.6 1.4 -0.8
Alcohol drinker status: Never 5.9 7.0 11.3 -2.0 -1.5 -3.4 -3.1 2.9
Ever smoked 3.1 5.4 10.2 -3.2 1.5 -2.5 -2.8 0.8
Basal metabolic rate 0.3 1.9 2.3 1.5 -1.5 1.1 1.2 -1.5
Leg fat percentage (left) 0.7 2.7 5.9 -2.4 -0.0 -1.4 -2.3 0.4
Arm fat-free mass (left) 0.4 2.2 2.9 1.7 -1.4 1.1 1.4 -1.6
Number of operations (self-reported) 0.3 0.4 1.1 0.5 0.0 0.2 0.8 -1.1
Average weekly beer plus cider intake 2.0 2.9 6.5 -1.4 -0.5 -1.2 -2.0 2.5
Irritability 0.8 1.3 3.5 0.7 1.2 1.9 0.8 -0.7
Risk taking 1.8 2.6 3.8 -1.9 0.2 -1.8 -2.0 1.6
Ever had prostate specific antigen (PSA) test 1.0 1.2 4.0 0.2 -0.9 0.1 1.0 -2.0
Fractured/broken bones in last 5 years 0.4 0.5 1.6 1.3 0.0 -0.3 0.8 -0.3
Age started oral contraceptive pill 1.2 1.5 3.6 1.2 -0.0 1.9 1.4 -0.7
Diastolic blood pressure, automated reading 1.6 4.9 19.8 1.6 -4.5 -1.2 0.7 -0.2
Ever depressed for a whole week 0.2 0.2 0.4 -0.5 0.4 -0.7 -0.4 0.5
Unable to work because of sickness or disability 1.4 1.9 6.6 -1.2 2.6 -0.3 -0.7 -0.8
Commuting to job workplace: Cycle 0.3 0.4 1.5 0.2 -1.2 -0.3 0.3 0.2
Myopia 0.7 1.1 2.6 0.2 -0.4 1.6 1.6 0.2
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.4 0.5 1.2 0.2 0.7 -1.0
Cholesterol lowering medication 1.6 2.3 3.5 -1.4 0.3 -1.5 -1.9 1.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 0.9 -0.6 0.1 -0.2 -0.9 1.0
Pain experienced in last month 0.4 0.6 1.0 1.0 -1.0 -0.3 0.1 1.0
Supplements: Calcium 0.3 0.3 0.9 0.1 -0.9 -0.8 0.1 -0.3
Basal cell carcinoma (self-reported) 0.5 0.6 1.0 0.6 -1.0 1.0 0.6 -0.4
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.6 -1.6 -0.1 -0.5 -1.1 0.0
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.5 0.1 0.0 -0.4 -0.2 -0.7
Heart disease (siblings) 2.4 3.0 4.8 -0.1 -2.1 -1.7 -1.7 2.2
Alcohol drinker status: Previous 0.8 0.9 3.3 0.0 1.8 0.3 0.2 -1.1
Pack years of smoking 1.0 1.5 2.8 -1.7 1.6 -0.5 -1.3 0.5
Impedance of whole body 1.1 5.5 14.4 -1.6 -0.6 -2.0 -2.4 3.8
Leg fat mass (left) 0.4 1.4 3.2 -1.6 -0.7 -0.9 -1.8 0.2
Arm predicted mass (left) 0.5 2.5 4.2 2.0 -1.3 1.2 1.6 -1.7