Hub : Genes

PTPRF

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0770	0.0360	3.9e-03	0.083	NA	0.038	NA	0.061	7.8e-07	NA	7.4e-04	NA	2.2e-05
2	GTEx	Skin Sun Exposed Lower leg	0.0530	0.0290	9.9e-03	0.015	NA	0.015	NA	0.023	2.1e-02	NA	1.9e-02	NA	5.1e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.0459	0.0162	5.6e-05	0.012	0.042	0.022	0.039	0.019	8.2e-03	4.1e-06	6.2e-04	7.8e-06	1.4e-03
4	TCGA	Pheochromocytoma and Paraganglioma	0.0700	0.0430	4.8e-03	0.013	0.038	0.001	NA	0.005	9.3e-02	1.3e-02	2.9e-01	NA	2.0e-01
5	TCGA	Thyroid Carcinoma	0.0310	0.0210	6.9e-03	0.011	0.030	0.039	NA	0.033	2.5e-02	5.8e-04	9.4e-05	NA	3.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.7	1.5	-0.9	1.2	-0.1	-1.0	-0.4
Bipolar Disorder or Schizophrenia	2.3	5.5	14.8	-2.2	1.2	-2.4	-3.8	1.0
Depressed Affect (Nagel 2018)	0.2	0.4	1.4	0.5	0.3	0.3	0.6	-1.2
Depression (Nagel 2018)	0.1	0.2	0.5	-0.7	0.1	0.3	-0.7	0.0
Intelligence (Savage-Jansen 2018)	2.5	7.6	16.5	4.1	-1.6	1.0	3.8	-1.9
Neuroticism (Nagel 2018)	0.7	1.6	3.4	1.9	-1.2	0.2	1.4	-0.9
Schizophrenia (2018)	3.2	6.6	17.0	-2.0	0.5	-3.0	-4.1	1.6
Schizophrenia vs Biploar Disorder	1.2	1.6	2.9	1.5	-1.7	-1.6	-0.1	0.8
Worry (Nagel 2018)	1.9	4.0	8.6	2.9	-0.8	1.3	2.8	-1.2
Alzheimer’s Disease (in mother)	0.6	0.7	2.0	-1.4	0.6	-0.6	-1.0	0.2
Alzheimer’s Disease (in father)	1.0	1.1	1.9	-0.5	0.4	-1.4	-1.2	1.2
Alzheimer’s Disease (including proxy)	0.7	1.0	1.3	-1.1	1.0	-0.9	-1.1	0.8
Crohns Disease (2017)	1.1	2.5	3.2	-1.8	-1.1	-1.5	-1.7	1.7
Irritable Bowel Disease (IBD)	0.3	0.7	1.5	-1.2	-0.1	-0.4	-1.2	0.7
Ulcerative Colitis (UC)	0.1	0.3	0.6	0.0	0.8	0.7	-0.4	-0.4
Major Depression (MDD)	1.8	2.2	3.5	-0.8	1.9	-1.6	-1.6	1.3
Reaction Time	3.4	6.4	10.6	-2.4	-1.8	-1.6	-3.2	3.2
Verbal and Numeric Reasoning (VNR)	1.3	3.2	7.0	2.7	-1.5	0.4	2.3	-1.1
Breast Cancer	2.7	6.6	10.0	-1.9	-1.0	-3.0	-3.2	3.0
Ovarian Cancer	1.3	1.7	7.7	0.7	-2.8	0.0	0.5	0.6
Prostate Cancer	1.1	1.6	3.4	1.8	0.0	-0.1	1.6	-1.3
Age at First Birth	1.9	2.8	5.9	2.4	-1.5	1.2	1.7	-1.2
Bipolar Disorder (2011)	0.4	0.4	1.1	0.0	1.0	0.6	0.5	-0.7
Body Mass Index (BMI) (2010)	0.6	0.9	2.4	-1.5	-0.4	-0.9	-1.0	0.1
Coronary Artery Disease (CAD)	0.5	0.5	2.1	-0.4	-1.4	0.2	-0.5	0.4
Crohns Disease (2012)	2.4	3.9	6.9	-1.9	-1.2	-2.6	-2.2	1.6
Mean Putamen Volume	0.5	0.6	1.5	0.2	0.2	-0.8	-0.8	1.2
Fasting Glucose	0.7	0.8	1.9	1.4	0.0	0.7	1.1	-0.8
HbA1C	1.4	1.6	4.2	-1.4	-0.0	-0.7	-1.2	2.0
HDL Cholesterol	0.6	0.9	2.0	0.9	0.8	0.8	1.4	-0.7
LDL Cholesterol	0.6	1.0	2.8	0.7	1.7	0.1	0.5	-1.2
Lupus	0.4	0.6	1.3	-0.0	1.1	0.0	-0.8	1.0
Neuroticism (2016)	1.2	1.7	5.5	0.9	-2.3	-0.3	-0.1	1.4
Primary Biliary Cirrhosis	0.4	0.5	1.5	1.2	-0.4	-0.5	0.3	0.8
Rheumatoid Arthritis	1.4	2.0	4.5	-1.4	-0.6	-1.1	-2.1	1.3
Schizophrenia (2014)	1.6	3.6	8.1	-1.8	0.3	-2.2	-2.8	1.2
Triglycerides	0.4	0.6	1.2	-0.1	1.0	1.1	-0.2	-0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.7	0.6	0.1	-0.2	-0.9
Ulcerative Colitis	0.2	0.3	0.8	-0.4	0.9	0.6	-0.4	-0.3
Blood Eosinophil Count	1.7	13.0	17.1	-1.9	-4.0	-4.1	-3.8	3.7
Blood Platelet Count	0.6	7.4	21.2	-2.0	-4.6	-1.5	-2.5	2.0
Blood Red Count	2.4	23.5	69.4	0.7	-8.3	-4.7	-2.2	4.6
Blood White Count	0.6	4.4	18.2	1.1	-4.3	1.1	1.1	-0.5
Heel T-Score	0.1	0.7	1.5	0.7	1.1	0.4	0.3	-1.2
BMI	0.1	0.7	1.3	-0.8	-0.5	-0.8	-0.6	-1.1
Height	0.1	2.8	9.8	1.2	-3.1	0.5	0.7	1.4
Waist Hip Ratio (WHR)	0.2	0.9	2.1	-1.1	0.7	-0.2	-1.4	0.9
Systolic Blood Pressure	1.6	8.2	22.7	2.7	-4.8	2.3	2.1	-1.0
Smoking Status	3.7	8.9	14.8	-3.8	3.3	-1.6	-3.7	1.7
Allergy or Eczema	1.5	3.9	11.4	0.3	1.1	2.0	1.7	-3.4
Cardiovascular Disease	0.1	0.4	1.2	0.3	-1.1	0.4	0.6	0.1
Hypothyroidism (self reported)	0.6	1.4	5.9	0.1	-2.4	-0.8	-0.2	0.8
Respiratory disease	0.2	0.4	0.7	-0.8	-0.6	0.2	-0.8	0.3
Type 2 Diabetes (T2D) (2018)	1.3	2.5	5.7	1.3	0.5	1.1	1.8	-2.4
Lung FEV1/FVC ratio	0.1	0.6	1.8	-1.0	-0.4	0.0	0.1	-1.3
Lung FVC	0.2	1.2	5.7	-0.2	-2.4	-0.4	-0.2	0.3
Neuroticism	0.8	1.9	5.9	2.4	-1.2	0.1	1.4	-0.1
Chronotype (morning person)	0.5	1.2	2.7	1.1	-1.7	-0.6	0.7	1.0
Hair Pigment	0.0	0.5	1.5	0.6	0.3	0.5	0.4	-1.2
Tanning	0.7	8.9	14.4	-2.3	-1.4	-3.5	-3.8	3.3
Hand grip strength (left)	0.3	0.7	1.9	-0.9	-1.4	0.1	-0.3	0.8
Number of treatments/medications taken	0.3	0.6	1.7	-1.3	0.7	0.0	-0.4	-0.8
Average weekly spirits intake	7.8	9.7	17.9	-2.5	-0.9	-3.0	-3.8	4.2
Sensitivity / hurt feelings	1.6	2.8	5.2	0.3	-2.3	-1.6	-1.9	1.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	-0.5	0.4	0.2	-0.7	-0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.4	-0.0	0.8	-0.8	-0.8	1.2
Relative age of first facial hair	6.2	12.7	21.4	-2.9	0.4	-4.0	-4.6	4.2
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.0	-2.0	-0.7	-1.8	-1.9	0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	-0.9	-0.0	0.0	-1.0	0.6
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	-0.1	0.8	-0.4	-0.2	-0.7
Systolic blood pressure, automated reading	1.5	4.3	19.2	1.4	-4.4	0.3	0.5	-0.2
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.8	-0.2	1.9	0.8	0.3	-1.1
Angina	0.5	0.7	2.3	-0.7	-1.5	0.2	-0.8	0.1
Medication for hormone replacement therapy	1.2	1.3	3.0	-1.1	0.7	-0.3	-1.7	1.4
Vitamin and mineral supplements	0.2	0.3	0.6	0.7	0.3	-0.1	0.8	-0.4
Supplements: Zinc	0.7	0.8	1.4	0.3	1.2	0.7	0.6	-1.2
Medication: Co-codamol	0.7	0.8	2.2	-0.4	-0.9	0.4	-0.8	1.5
Medication: Metformin	1.3	1.8	3.4	0.9	1.8	1.3	1.0	-1.5
Diabetes (father)	0.8	0.9	4.3	0.1	-2.1	-0.1	0.7	0.1
Diabetes (mother)	2.4	3.0	5.4	-1.8	-0.1	-1.8	-2.3	1.8
Severe depression (siblings)	0.3	0.3	0.6	-0.4	0.8	0.4	0.1	0.7
Pack years adult smoking proportion	1.5	2.2	3.9	-2.0	1.5	-1.0	-1.8	0.8
Impedance of leg (right)	1.5	7.2	15.4	-2.6	-0.1	-2.1	-3.0	3.9
Leg fat-free mass (left)	0.4	2.0	2.6	1.4	-1.5	1.3	1.3	-1.6
Trunk fat percentage	0.7	2.8	5.7	-2.0	-0.5	-1.7	-2.4	0.9
Hand grip strength (right)	0.7	1.9	6.1	-0.4	-2.5	-1.1	-0.7	1.2
Townsend deprivation index at recruitment	1.9	2.7	4.4	-1.9	2.1	-1.0	-2.0	0.7
Current tobacco smoking	4.5	7.3	12.0	-2.9	2.2	-2.2	-3.5	2.6
Average weekly fortified wine intake	1.4	1.7	2.7	0.8	1.1	1.6	1.4	-1.4
Maternal smoking around birth	2.4	3.4	6.2	-1.8	2.5	-0.9	-2.5	0.8
Fed-up feelings	0.4	0.8	1.2	-1.0	-0.8	-0.9	-1.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	5.6	-1.9	-0.2	-0.7	-2.4	1.1
Relative age voice broke	5.4	8.2	15.6	-2.9	0.0	-2.9	-4.0	3.0
Taking other prescription medications	0.2	0.4	0.7	-0.8	0.5	0.5	-0.3	-0.9
Age when periods started (menarche)	4.5	10.8	22.0	-4.4	1.4	-2.5	-4.7	2.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.0	0.2	0.3	-0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	-0.0	0.5	1.2	0.7	-0.9
Tinnitus: Yes, but not now, but have in the past	3.7	3.9	8.8	1.9	-0.2	1.6	3.0	-2.2
Qualifications: CSEs or equivalent	2.2	2.9	4.3	-1.2	-0.9	-2.0	-2.1	2.0
Serious illness, injury or assault to yourself	0.6	0.7	1.5	-1.1	1.2	-0.4	-0.8	0.5
High blood pressure	0.1	0.4	1.3	0.1	-1.2	0.0	-0.0	0.7
Hayfever, allergic rhinitis or eczema	1.1	2.5	8.9	-0.6	1.1	1.2	0.8	-3.0
Multivitamins +/- minerals	0.5	0.6	1.8	-1.3	0.4	-0.2	-1.1	-0.1
Stomach or abdominal pain in last month	0.3	0.4	0.8	0.9	0.4	0.8	0.7	-0.1
Supplements: Glucosamine	0.2	0.2	0.6	-0.5	-0.1	-0.2	-0.8	0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	0.5	1.1	0.4	0.5	-0.9
Medication: Atenolol	0.3	0.3	0.8	-0.9	-0.4	0.1	0.1	-0.8
Medication: Levothyroxine sodium	0.5	0.9	3.1	-0.5	-1.8	-0.8	-0.6	0.4
Sitting height	1.6	11.2	21.0	3.9	-1.0	3.1	4.6	-3.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	-0.9	-0.0	-0.9	-0.6	1.3
High blood pressure (mother)	0.8	1.1	2.6	0.9	-0.1	1.6	1.4	-0.6
Body mass index (BMI)	0.2	0.7	1.3	-1.1	-0.2	-0.6	-0.9	-1.1
Impedance of leg (left)	1.4	6.6	15.8	-1.9	-0.3	-2.2	-2.9	4.0
Leg predicted mass (left)	0.3	1.9	2.5	1.3	-1.6	1.2	1.2	-1.5
Trunk fat mass	0.3	1.4	2.9	-1.4	-0.8	-1.1	-1.7	0.4
Waist circumference	0.1	0.5	1.3	-1.2	-0.1	-0.1	-0.9	-0.6
Number of incorrect matches in round	0.4	0.6	1.7	-0.8	-0.5	-0.3	-1.3	0.6
Past tobacco smoking	3.1	5.7	11.4	3.4	-1.5	2.1	3.1	-0.9
Alcohol usually taken with meals	3.6	5.8	13.1	1.7	-0.4	2.4	3.6	-2.6
Nervous feelings	1.3	2.5	6.6	2.6	-1.5	0.8	1.7	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-0.4	0.3	0.8	-0.3	-1.1
Hearing difficulty/problems with background noise	1.4	2.3	4.7	-0.7	0.2	-1.5	-2.2	2.0
Hair/balding pattern: Pattern 2	0.8	1.1	2.2	1.5	0.3	0.8	1.5	-0.5
Had menopause	0.6	0.7	1.4	-1.2	-0.7	1.2	-0.5	0.2
Had other major operations	2.9	3.5	6.8	2.1	0.5	1.7	2.6	-1.9
Forced vital capacity (FVC)	0.7	2.7	12.9	0.6	-3.6	-0.0	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	0.3	0.4	0.9	0.6	-1.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	5.0	-2.2	0.9	-1.1	-1.8	1.0
Qualifications: None of the above	9.5	20.3	41.0	-5.1	0.5	-4.7	-6.4	3.5
Financial difficulties in last 2 years	2.0	2.7	8.6	-2.9	1.1	-0.3	-1.8	-0.2
Mouth/teeth dental problems	0.6	0.9	2.2	1.0	-0.6	0.4	1.5	-0.8
Heart attack	0.9	1.1	3.1	-1.8	-0.1	-0.8	-1.3	0.1
Allergy	0.9	2.1	7.3	0.4	-0.7	-1.3	-0.8	2.7
Pain all over the body in last month	0.3	0.3	0.7	-0.4	0.8	-0.6	-0.4	-0.5
Diabetes (self-reported)	2.0	3.1	6.5	1.3	1.4	1.6	1.7	-2.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.9	-1.4	0.5	-0.4	-0.8	0.2
Medication: Ramipril	0.1	0.2	0.3	0.3	0.5	-0.5	-0.2	0.5
Medication: Simvastatin	0.4	0.6	0.9	-0.8	1.0	-0.9	-0.6	0.6
Fluid intelligence score	4.0	8.3	16.3	3.5	-0.4	2.3	4.0	-2.8
Illnesses of siblings	0.2	0.3	0.9	0.7	-0.2	0.1	1.0	-0.2
Neuroticism score	0.5	1.0	2.4	0.7	-1.5	-1.0	-0.3	0.9
Weight	0.1	0.5	2.0	-0.0	-1.4	-0.0	-0.3	-0.7
Impedance of arm (right)	1.3	6.2	12.7	-2.4	-0.9	-2.2	-2.6	3.6
Arm fat percentage (right)	0.9	3.6	7.6	-2.8	-0.7	-1.8	-2.5	0.7
Trunk fat-free mass	0.5	2.6	3.6	1.9	-1.3	1.5	1.6	-1.8
Hip circumference	0.1	0.6	2.4	-0.4	-1.5	0.3	-0.0	-0.7
Time employed in main current job	1.5	1.7	6.0	1.0	-2.4	-0.8	0.3	0.9
Alcohol intake versus 10 years previously	10.2	15.3	24.0	-4.7	-0.9	-4.3	-4.9	3.4
Father’s age at death	0.5	0.7	1.4	0.8	1.2	0.7	0.8	-0.6
Worrier / anxious feelings	1.6	3.1	6.1	2.3	-1.1	1.5	2.5	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.5	0.2	0.2	-0.1	0.2	-0.7
Falls in the last year	1.1	1.4	5.0	-2.2	0.3	-0.6	-1.2	0.3
Hair/balding pattern: Pattern 3	0.6	0.9	2.2	0.4	-1.5	0.5	0.9	-0.9
Number of live births	0.4	0.6	1.4	-0.4	-0.3	-1.2	-1.1	0.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	12.6	0.7	-3.5	0.0	0.8	-0.3
Pulse rate	1.0	1.8	3.7	-0.8	-1.7	-1.9	-1.2	0.2
Happiness	0.7	0.8	2.3	0.3	0.0	0.7	1.1	-1.5
Noisy workplace	4.2	5.2	9.3	-2.7	0.6	-2.4	-3.0	1.9
Qualifications: A levels/AS levels or equivalent	7.4	16.5	33.8	4.3	0.3	3.6	5.8	-4.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.6	1.2	1.2	1.0	1.1	-0.4
Mouth/teeth dental problems: Dentures	5.5	9.3	18.2	-2.4	-1.5	-3.3	-4.3	3.1
Asthma	0.1	0.1	0.3	0.2	0.2	0.4	0.3	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	0.6	-1.1	-0.6	0.4	0.0
Medication: Cholesterol lowering	0.7	1.1	4.0	-1.0	2.0	-0.3	-0.4	-0.4
Depression (self-reported)	1.3	1.6	4.3	-1.1	2.1	-0.5	-1.4	0.3
Medication: Lansoprazole	1.2	1.4	5.3	0.8	2.3	0.6	0.3	-0.7
Prospective memory result	0.1	0.2	0.4	0.2	0.7	-0.3	-0.5	0.2
Lung cancer (father)	0.2	0.2	0.7	0.2	0.4	0.4	-0.0	-0.8
Illnesses of mother	1.0	1.2	1.8	0.8	1.1	0.9	1.3	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	11.5	0.9	-3.4	0.3	1.0	-0.2
Pulse wave Arterial Stiffness index	4.5	5.2	8.6	-1.7	-1.0	-2.9	-2.9	2.2
Impedance of arm (left)	0.9	4.0	10.6	-1.5	-0.9	-1.6	-1.9	3.2
Arm fat mass (right)	0.3	1.4	2.5	-1.6	-0.9	-1.0	-1.6	0.1
Trunk predicted mass	0.4	2.5	3.3	1.8	-1.4	1.4	1.5	-1.6
Standing height	0.3	3.3	7.1	2.4	-2.7	1.3	1.3	0.5
Length of working week for main job	0.9	1.0	2.4	-0.3	-0.1	0.7	1.6	-1.5
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.9	0.5	-0.1	-0.5	-0.5
Breastfed as a baby	0.6	0.8	2.0	1.4	0.6	0.5	0.9	-0.7
Tense / ‘highly strung’	0.2	0.4	0.8	0.8	-0.9	-0.2	0.4	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.4	7.7	-0.1	2.8	1.0	0.9	-1.5
Hair/balding pattern: Pattern 4	0.5	1.1	2.9	-0.1	-1.7	0.8	1.2	-0.7
Birth weight of first child	0.2	0.4	1.1	-1.1	-0.7	-0.3	0.1	-0.2
Peak expiratory flow (PEF)	0.9	2.1	3.8	1.1	-1.7	0.9	1.9	-1.2
Pulse wave reflection index	1.5	1.8	2.5	-1.2	-1.3	-1.6	-1.5	1.1
Ever highly irritable/argumentative for 2 days	2.0	2.4	4.5	-2.1	-0.4	-1.4	-1.6	1.6
Loud music exposure frequency	1.9	2.1	5.5	-2.3	-0.7	-0.6	-1.7	1.2
Qualifications: O levels/GCSEs or equivalent	4.9	7.8	15.4	3.2	0.0	2.2	3.9	-2.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.8	0.6	1.3	0.7	0.4	0.3
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.2	-0.1	-0.4	-0.3	-0.7
Medication: Paracetamol	1.1	1.9	4.1	-2.0	-0.4	-1.5	-1.3	1.0
Headache pain in last month	0.1	0.2	0.5	-0.4	0.7	-0.3	0.4	-0.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	4.2	0.6	-2.0	-0.3	-0.2	0.8
Glaucoma (self-reported)	1.1	1.3	2.6	1.0	-0.3	1.6	1.6	-0.5
Gout (self-reported)	0.3	0.4	0.7	-0.7	-0.2	0.8	-0.8	0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.1	-0.2	-2.0	-1.3	-0.5	0.8
Medication: Amlodipine	0.4	0.5	1.4	-0.1	1.2	0.9	0.6	-0.4
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.1	0.4	1.4	1.1	0.8	-1.4
Birth weight	0.2	0.5	0.8	0.9	0.7	0.5	0.8	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	0.1	1.0	-1.1	-0.1	-0.1
High blood pressure (siblings)	0.6	0.8	1.7	0.5	1.0	0.8	0.6	-1.3
Forced vital capacity (FVC), Best measure	0.8	2.8	11.9	0.8	-3.5	0.4	1.1	0.1
Body fat percentage	0.9	3.7	7.4	-2.5	-0.3	-2.0	-2.7	1.0
Leg fat percentage (right)	0.9	3.4	8.4	-2.9	0.1	-1.5	-2.5	0.4
Arm fat-free mass (right)	0.6	3.0	5.1	2.3	-1.6	1.3	1.6	-1.6
Exposure to tobacco smoke outside home	0.4	0.6	2.3	-0.1	1.5	0.3	-0.6	-0.5
Comparative body size at age 10	0.1	0.2	0.9	-0.4	1.0	-0.3	-0.3	0.1
Number of full brothers	1.0	1.3	3.0	-0.4	-0.6	-1.4	-1.7	0.9
Worry too long after embarrassment	2.9	4.8	13.0	1.0	-3.6	-2.4	-0.6	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	7.0	-0.3	2.6	1.5	0.5	-0.9
Wheeze or whistling in the chest in last year	0.6	1.0	3.9	-2.0	0.7	0.7	-0.0	-0.5
Number of children fathered	0.5	0.6	1.8	0.7	-1.4	0.3	0.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.3	-1.2	-0.3	-0.6	-1.5	1.4
Age at first live birth	3.4	6.0	12.5	2.4	-0.8	2.9	3.5	-1.8
Pulse wave peak to peak time	4.3	5.0	8.5	1.8	0.8	2.9	2.9	-2.1
Health satisfaction	0.8	1.0	4.6	0.2	-0.1	-0.0	0.6	-2.1
Shortness of breath walking on level ground	1.0	1.2	2.6	-1.6	-0.6	-0.8	-1.5	0.4
Qualifications: College or University degree	8.5	26.9	53.7	5.2	-0.1	5.7	7.3	-4.6
Eye problems/disorders: None of the above	0.8	1.0	1.7	-0.9	-0.6	-1.1	-1.3	0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.4	0.5	0.1	-0.3	-0.4
Emphysema/chronic bronchitis	1.0	1.1	3.0	-1.4	1.7	-0.2	-0.8	-0.2
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	0.4	0.4	0.1	0.1	0.1
Neck or shoulder pain in last month	0.8	1.1	2.4	-1.5	-0.4	-0.7	-1.5	0.6
Medication: Blood pressure	0.3	0.5	1.4	-0.3	1.2	0.8	0.5	-0.5
Angina (self-reported)	0.4	0.5	2.3	-0.4	-1.5	0.1	-0.5	-0.1
Migraine (self-reported)	1.2	1.6	3.7	1.3	0.7	1.4	1.9	-0.4
Medication: Ibuprofen	0.6	0.7	2.2	0.5	-1.5	-0.9	0.3	0.4
Medication: Allopurinol	0.4	0.5	1.1	-1.0	0.2	0.8	-0.7	-0.4
Medication: Omeprazole	0.5	0.6	1.5	-1.2	0.7	0.1	-0.8	0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.4	-1.2	-0.7	0.7	-0.9	0.1
Mean time to correctly identify matches	4.7	8.9	14.4	-2.8	-2.2	-2.3	-3.8	3.5
Heart disease (mother)	0.7	0.8	2.0	1.4	-1.3	-0.2	0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	0.8	-0.2	-1.1	-0.5	0.7
Whole body fat mass	0.3	1.4	3.1	-1.4	-0.7	-1.1	-1.8	0.3
Leg fat mass (right)	0.4	1.7	3.6	-1.8	-0.5	-1.1	-1.9	0.2
Arm predicted mass (right)	0.6	3.1	5.2	2.3	-1.4	1.6	1.8	-1.7
Pulse rate, automated reading	0.5	1.6	3.7	1.1	-0.4	0.6	1.6	-1.9
Alcohol intake frequency.	1.4	3.2	6.5	-1.9	-0.1	-2.5	-2.4	0.6
Comparative height size at age 10	1.0	5.7	10.8	3.3	-2.1	2.1	2.9	0.3
Number of full sisters	0.9	1.2	1.8	-1.1	0.5	-1.3	-1.1	1.2
Suffer from ‘nerves’	0.6	0.9	1.8	0.3	-1.3	-0.9	-0.2	1.3
Overall health rating	0.5	1.1	1.9	-1.3	1.4	-0.8	-1.1	-0.5
Chest pain or discomfort	2.7	3.9	6.2	1.6	1.6	2.5	2.3	-1.8
Had major operations	0.8	1.0	3.5	1.9	0.2	0.7	0.6	-0.6
Age at last live birth	1.8	2.6	4.3	1.4	-1.8	1.6	2.1	-0.7
Family relationship satisfaction	0.6	0.7	1.7	-0.7	1.3	-1.0	-0.1	-0.6
Leg pain on walking	0.6	0.8	1.5	-1.2	-0.6	-0.3	-1.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.6	-0.6	-0.3	-1.6	-1.1	1.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.4	0.6	-0.4	-0.3	0.1
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	5.1	2.0	-2.3	-0.3	0.5	0.2
Medication: Aspirin	0.6	0.9	1.9	-1.4	0.3	0.6	0.4	-1.3
Supplements: Vitamin C	0.3	0.3	0.6	0.7	-0.0	0.6	0.2	0.7
Knee pain experienced in last month	0.0	0.1	0.1	-0.2	-0.3	-0.2	-0.3	0.3
Hypertension (Self-reported)	0.1	0.2	0.6	0.3	-0.8	0.3	0.3	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	4.6	-0.5	2.1	0.1	0.4	-1.0
Illnesses of father: Heart disease	0.6	0.9	3.9	-0.6	-2.0	0.0	-0.1	-0.2
Illnesses of siblings: Diabetes	2.5	3.1	6.7	-2.6	1.1	-1.5	-2.0	1.0
Smoking status: Previous	2.0	3.0	7.0	-2.6	1.5	-1.0	-2.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.0	0.9	-1.4	0.7	0.5	0.4
Whole body fat-free mass	0.5	2.9	3.8	1.9	-1.4	1.5	1.7	-1.9
Leg fat-free mass (right)	0.6	3.0	3.8	1.9	-1.8	1.4	1.7	-1.8
Arm fat percentage (left)	0.7	3.0	6.0	-2.5	-1.0	-1.5	-2.3	0.7
Average weekly red wine intake	2.6	3.9	9.6	1.8	-0.6	2.1	3.1	-1.3
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.5	1.9	0.4	1.5	0.8	0.0
Mood swings	0.2	0.4	1.2	0.5	0.5	0.2	-0.1	-1.1
Loneliness, isolation	0.2	0.3	0.7	-0.8	-0.4	-0.2	-0.8	-0.1
Long-standing illness, disability or infirmity	1.0	1.5	3.4	-0.9	-1.2	-1.9	-1.3	0.4
Ever had bowel cancer screening	1.1	1.3	3.7	0.8	0.1	0.2	1.4	-1.9
Diabetes diagnosed by doctor	0.8	1.3	3.2	0.6	1.0	0.9	1.1	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.1	-0.7	0.6	-1.0	-0.8	-0.4
Friendships satisfaction	0.1	0.1	0.2	0.0	0.4	-0.4	0.4	-0.1
Qualifications: nursing, teaching	5.8	9.1	19.8	2.9	0.9	3.0	4.4	-2.8
Commuting to job workplace: Walk	0.7	0.8	1.2	-0.8	-0.8	-0.6	-1.1	1.0
Eye problems/disorders: Cataract	0.1	0.1	0.5	-0.1	-0.2	0.2	-0.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.7	0.2	1.9	0.8	0.7	-1.3
Medication for cholesterol	1.0	1.5	4.2	0.3	0.8	0.9	1.4	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.3	6.0	-1.1	-0.4	-0.9	-1.8	2.5
Back pain experienced in last month	0.5	0.8	1.7	-1.3	-0.5	-0.7	-1.1	0.5
Mineral and other dietary supplements	0.5	0.7	2.7	-0.5	1.6	0.5	0.3	-0.5
Breast cancer (self-reported)	0.6	0.7	1.1	0.3	0.6	1.1	0.9	-1.1
Asthma (self-reported)	0.0	0.1	0.2	0.0	0.1	0.1	0.2	-0.5
Osteoporosis (self-reported)	0.6	0.8	2.6	1.6	-0.0	-0.5	0.8	-0.5
Osteoarthritis (self-reported)	0.4	0.5	1.5	-0.5	1.2	0.4	-0.1	-0.9
Medication: Aspirin	0.6	0.8	2.2	-1.2	0.4	0.5	0.4	-1.5
Medication: Gliclazide	0.1	0.2	0.3	-0.4	0.6	-0.5	-0.4	-0.2
Illnesses of father: None of the above (group 1)	0.8	1.0	3.3	-0.4	1.8	0.2	-0.8	0.9
Smoking status: Current	4.1	6.5	11.3	-2.7	1.8	-2.3	-3.4	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.0	1.7	-1.2	0.9	1.4	-1.2
Whole body water mass	0.5	3.0	4.0	2.0	-1.4	1.5	1.8	-1.9
Leg predicted mass (right)	0.6	3.0	3.9	2.0	-1.8	1.4	1.7	-1.8
Arm fat mass (left)	0.2	1.0	1.8	-1.3	-1.0	-0.7	-1.3	-0.1
Number of self-reported non-cancer illnesses	0.0	0.1	0.3	-0.5	0.1	0.1	-0.1	-0.2
Average weekly champagne plus white wine intake	6.4	8.7	10.8	2.3	2.8	3.3	3.3	-3.0
Miserableness	1.1	1.8	3.2	1.7	0.5	1.1	1.8	-1.3
Guilty feelings	3.8	5.8	7.1	-2.0	-2.7	-2.6	-2.6	2.1
Wears glasses or contact lenses	0.5	0.6	1.6	0.8	0.4	1.3	0.7	-0.1
Ever taken oral contraceptive pill	0.3	0.3	1.2	0.4	1.1	0.2	-0.4	0.0
Hearing aid user	0.8	0.9	1.5	-1.1	-1.2	-0.6	-1.1	-0.1
Mother’s age at death	0.4	0.5	1.3	-0.4	-1.1	-1.1	-0.2	0.0
Financial situation satisfaction	0.5	0.7	1.2	0.9	-0.0	0.7	0.9	-1.1
Tinnitus: Yes, now most or all of the time	2.3	2.7	4.0	-1.3	-0.9	-2.0	-2.0	1.7
Commuting to job workplace: Public transport	1.5	1.8	3.0	1.1	-1.5	1.0	1.7	-1.3
Eye problems/disorders: Glaucoma	0.8	1.0	2.2	0.3	-0.1	1.5	1.4	-0.9
Medication: Blood pressure	0.4	0.8	2.4	1.6	-1.0	0.0	0.5	0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.7	0.5	1.3	1.2	0.9	-1.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	4.1	0.5	-2.0	-0.1	0.1	0.5
High cholesterol (Self-reported)	0.3	0.5	2.6	0.0	1.6	-0.0	-0.3	-0.0
Medication: Bendroflumethiazide	0.3	0.4	0.8	0.9	-0.7	-0.7	0.4	0.5
Medication: Paracetamol	2.0	3.0	5.2	-2.3	-1.0	-1.9	-1.7	1.5
Medication: Lisinopril	0.4	0.5	1.6	1.2	-0.4	0.2	0.6	-0.5
Medication: Atorvastatin	0.3	0.4	1.3	-0.4	-1.1	0.3	-0.5	0.2
Illnesses of father: High blood pressure	1.1	1.4	3.3	1.8	-0.8	0.6	1.4	-0.8
Alcohol drinker status: Never	5.9	7.0	11.3	-2.0	-1.5	-3.4	-3.1	2.9
Ever smoked	3.1	5.4	10.2	-3.2	1.5	-2.5	-2.8	0.8
Basal metabolic rate	0.3	1.9	2.3	1.5	-1.5	1.1	1.2	-1.5
Leg fat percentage (left)	0.7	2.7	5.9	-2.4	-0.0	-1.4	-2.3	0.4
Arm fat-free mass (left)	0.4	2.2	2.9	1.7	-1.4	1.1	1.4	-1.6
Number of operations (self-reported)	0.3	0.4	1.1	0.5	0.0	0.2	0.8	-1.1
Average weekly beer plus cider intake	2.0	2.9	6.5	-1.4	-0.5	-1.2	-2.0	2.5
Irritability	0.8	1.3	3.5	0.7	1.2	1.9	0.8	-0.7
Risk taking	1.8	2.6	3.8	-1.9	0.2	-1.8	-2.0	1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.0	0.2	-0.9	0.1	1.0	-2.0
Fractured/broken bones in last 5 years	0.4	0.5	1.6	1.3	0.0	-0.3	0.8	-0.3
Age started oral contraceptive pill	1.2	1.5	3.6	1.2	-0.0	1.9	1.4	-0.7
Diastolic blood pressure, automated reading	1.6	4.9	19.8	1.6	-4.5	-1.2	0.7	-0.2
Ever depressed for a whole week	0.2	0.2	0.4	-0.5	0.4	-0.7	-0.4	0.5
Unable to work because of sickness or disability	1.4	1.9	6.6	-1.2	2.6	-0.3	-0.7	-0.8
Commuting to job workplace: Cycle	0.3	0.4	1.5	0.2	-1.2	-0.3	0.3	0.2
Myopia	0.7	1.1	2.6	0.2	-0.4	1.6	1.6	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.4	0.5	1.2	0.2	0.7	-1.0
Cholesterol lowering medication	1.6	2.3	3.5	-1.4	0.3	-1.5	-1.9	1.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.9	-0.6	0.1	-0.2	-0.9	1.0
Pain experienced in last month	0.4	0.6	1.0	1.0	-1.0	-0.3	0.1	1.0
Supplements: Calcium	0.3	0.3	0.9	0.1	-0.9	-0.8	0.1	-0.3
Basal cell carcinoma (self-reported)	0.5	0.6	1.0	0.6	-1.0	1.0	0.6	-0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.6	-1.6	-0.1	-0.5	-1.1	0.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	0.1	0.0	-0.4	-0.2	-0.7
Heart disease (siblings)	2.4	3.0	4.8	-0.1	-2.1	-1.7	-1.7	2.2
Alcohol drinker status: Previous	0.8	0.9	3.3	0.0	1.8	0.3	0.2	-1.1
Pack years of smoking	1.0	1.5	2.8	-1.7	1.6	-0.5	-1.3	0.5
Impedance of whole body	1.1	5.5	14.4	-1.6	-0.6	-2.0	-2.4	3.8
Leg fat mass (left)	0.4	1.4	3.2	-1.6	-0.7	-0.9	-1.8	0.2
Arm predicted mass (left)	0.5	2.5	4.2	2.0	-1.3	1.2	1.6	-1.7