TWAS hub - DPH2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Liver Hepatocellular Carcinoma	0.0630	0.036	0.00580	0.014	0.024	0.021	NA	0.008	7e-02	0.02600	3.3e-02	NA	0.12000
2	TCGA	Prostate Adenocarcinoma	0.0345	0.021	0.00033	0.031	0.036	0.039	NA	0.031	3e-04	0.00011	5.8e-05	NA	0.00028

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Qualifications: None of the above	14.3	30.5	45.6	3.9	6.8
Alcohol intake versus 10 years previously	12.6	18.9	27.9	3.1	5.3
Qualifications: College or University degree	10.3	32.5	46.4	-4.3	-6.8
Medication: Paracetamol	9.1	14.1	15.8	3.5	4.0
Qualifications: A levels/AS levels or equivalent	9.0	20.0	28.0	-3.5	-5.3
Age at first live birth	8.5	15.0	24.8	-2.3	-5.0
Qualifications: nursing, teaching	7.7	11.9	18.3	-2.4	-4.3
Maternal smoking around birth	7.3	10.6	19.2	1.4	4.4
Heart disease (siblings)	7.3	9.0	12.2	2.4	3.5
Fluid intelligence score	7.1	14.7	19.8	-3.1	-4.4
Illnesses of siblings	6.8	9.5	10.2	-3.2	-3.0
Medication: Paracetamol	6.8	11.3	13.0	3.6	3.1
Alcohol usually taken with meals	6.6	10.6	14.4	-2.6	-3.8
Qualifications: CSEs or equivalent	6.4	8.5	8.8	2.9	3.0
Qualifications: O levels/GCSEs or equivalent	6.3	10.0	16.2	-2.0	-4.0
Illnesses of father: None of the above (group 1)	6.0	7.4	7.5	-2.7	-2.7
Illnesses of mother	5.4	6.7	7.3	-2.5	-2.7
Loud music exposure frequency	5.4	5.9	7.5	2.1	2.7
Guilty feelings	5.4	8.1	11.2	2.2	3.4
Ever unenthusiastic/disinterested for a whole week	5.3	6.5	8.4	2.1	2.9
Overall health rating	5.2	11.2	11.9	3.5	3.2
Average weekly red wine intake	4.8	7.2	10.0	-2.1	-3.2
Average weekly fortified wine intake	4.3	5.0	5.5	-2.4	-2.1
Noisy workplace	4.3	5.3	6.8	1.9	2.6
Number of live births	4.1	5.7	8.6	1.7	2.9
Verbal and Numeric Reasoning (VNR)	4.0	9.6	10.4	-3.2	-3.0
Average weekly spirits intake	4.0	5.0	7.9	1.5	2.8
Chronic bronchitis/emphysema (mother)	4.0	4.6	5.2	2.3	2.0
Number of full brothers	4.0	5.1	5.2	2.2	2.3
Illnesses of father: Heart disease	4.0	5.5	7.3	1.9	2.7
Average weekly champagne plus white wine intake	4.0	5.5	8.1	-1.7	-2.8
Serious illness, injury or assault of a close relative in last 2 years	3.7	4.3	4.8	-2.0	-2.2
Intelligence (Savage-Jansen 2018)	3.6	11.0	11.4	-3.4	-3.3
Schizophrenia (2018)	3.6	7.6	12.3	1.7	3.5
Age at last live birth	3.6	5.3	9.6	-1.0	-3.1
Prospective memory result	3.5	4.3	5.2	1.8	2.3
Number of treatments/medications taken	3.4	6.1	10.1	3.2	1.4
Alcohol drinker status: Never	3.2	3.8	5.4	1.5	2.3
Mean Putamen Volume	3.1	3.5	3.6	1.9	1.8
Medication: Co-codamol	3.1	3.6	4.4	1.7	2.1
Diabetes (mother)	3.1	3.9	4.3	1.9	2.1
Leg fat percentage (right)	3.0	10.7	14.6	2.6	3.8
Shortness of breath walking on level ground	3.0	3.6	5.3	1.4	2.3
Neck or shoulder pain in last month	3.0	4.3	5.1	1.9	2.3
Alcohol intake frequency.	3.0	6.9	9.1	2.2	3.0
Illnesses of siblings: Diabetes	3.0	3.7	4.6	2.1	1.7
Medication for cholesterol, blood pressure or diabetes	2.8	4.7	5.2	-2.3	-2.0
Schizophrenia (2014)	2.7	6.0	9.6	1.6	3.1
Ovarian Cancer	2.5	3.3	3.4	-1.8	-1.8
Fasting Glucose	2.5	2.9	2.9	-1.7	-1.7
Medication: Simvastatin	2.5	3.7	5.4	2.3	1.4
Health satisfaction	2.5	3.2	3.3	1.8	1.8
Leg fat percentage (left)	2.5	9.0	11.9	2.5	3.4
Basal cell carcinoma (self-reported)	2.5	3.0	4.6	-2.1	-1.2
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	4.6	2.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.2	5.6	-2.4	-2.2
Commuting to job workplace: Public transport	2.4	2.9	3.9	-1.4	-2.0
Cholesterol lowering medication	2.4	3.5	4.9	1.5	2.2
Ever had hysterectomy (womb removed)	2.3	2.6	3.2	1.4	1.8
Townsend deprivation index at recruitment	2.3	3.2	4.9	1.2	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.2	9.1	-3.0	-2.3
Forced vital capacity (FVC), Best measure	2.3	8.6	9.9	-3.1	-2.7
Leg fat mass (right)	2.3	8.8	11.6	2.5	3.4
Illnesses of father: High blood pressure	2.3	2.9	5.4	2.3	0.6
Schizophrenia vs Biploar Disorder	2.2	2.9	3.0	1.7	1.7
Medication for pain relief, constipation, heartburn	2.2	3.8	5.7	-2.4	-1.4
Long-standing illness, disability or infirmity	2.1	3.2	4.0	1.6	2.0
Bipolar Disorder or Schizophrenia	2.0	4.9	9.1	0.8	3.0
Pack years adult smoking proportion	2.0	3.1	4.6	1.2	2.1
Number of incorrect matches in round	2.0	3.3	3.4	1.9	1.8
Arm fat percentage (right)	2.0	7.8	11.7	2.0	3.4
Arm fat mass (right)	1.9	7.9	10.3	2.3	3.2
Breastfed as a baby	1.9	2.4	3.2	-1.3	-1.8
High blood pressure (siblings)	1.9	2.7	2.9	1.7	1.6
Mean time to correctly identify matches	1.9	3.7	5.1	1.5	2.2
Leg fat mass (left)	1.9	7.4	9.6	2.3	3.1
Breast Cancer	1.8	4.3	4.9	1.9	2.2
Past tobacco smoking	1.8	3.3	6.5	-0.5	-2.5
Body fat percentage	1.8	7.1	11.1	1.8	3.3
Miserableness	1.8	3.0	4.1	-1.4	-2.0
Blood Eosinophil Count	1.7	13.3	21.0	2.4	4.6
BMI	1.7	9.8	10.7	3.0	3.3
Sensitivity / hurt feelings	1.7	3.0	4.5	1.2	2.1
Whole body fat mass	1.7	7.1	9.9	2.1	3.1
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.0	1.7	0.9
Smoking status: Current	1.7	2.7	4.9	0.7	2.2
Number of self-reported non-cancer illnesses	1.7	2.9	5.0	2.2	0.8
Pack years of smoking	1.7	2.5	3.9	1.0	2.0
HDL Cholesterol	1.6	2.6	4.6	-0.8	-2.2
Relative age of first facial hair	1.6	3.3	6.5	-0.5	2.5
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	2.5	-1.6	-1.1
Stomach or abdominal pain in last month	1.6	1.9	2.6	-1.6	-1.1
Mouth/teeth dental problems: Dentures	1.6	2.6	4.1	1.0	2.0
Myopia	1.6	2.3	2.7	-1.4	-1.6
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.5	0.7	1.9
Vitamin and mineral supplements	1.5	2.1	2.6	-1.6	-1.2
Current tobacco smoking	1.5	2.5	4.3	0.9	2.1
Relative age voice broke	1.5	2.3	4.5	-2.1	0.4
Medication: Cholesterol lowering	1.5	2.4	3.1	1.8	1.3
Migraine (self-reported)	1.5	1.8	3.2	0.6	-1.8
Medication for cholesterol	1.5	2.2	3.3	-1.8	-1.1
Arm fat mass (left)	1.5	6.0	8.0	2.0	2.8
Ever depressed for a whole week	1.5	1.8	3.3	0.6	1.8
Major Depression (MDD)	1.4	1.7	2.3	1.5	1.0
Diabetes (father)	1.4	1.7	2.6	0.9	1.6
Waist circumference	1.4	5.0	7.6	1.6	2.8
Father’s age at death	1.4	1.8	3.1	-0.8	-1.8
Depression (self-reported)	1.4	1.7	2.0	1.4	1.2
Body Mass Index (BMI) (2010)	1.3	1.7	1.7	1.3	1.3
Lung FVC	1.3	6.4	9.0	-3.0	-1.9
Trunk fat percentage	1.3	5.1	8.1	1.4	2.9
Body mass index (BMI)	1.3	5.4	6.8	2.0	2.6
Trunk fat mass	1.3	5.6	8.1	1.8	2.8
Medication: Ibuprofen	1.3	1.6	1.9	1.4	1.1
Mineral and other dietary supplements	1.3	1.8	3.1	-1.8	-0.7
Supplements: Fish oil (including cod liver oil)	1.3	1.6	3.0	1.7	0.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.2	1.0	1.5
Arm fat percentage (left)	1.2	4.7	7.8	1.3	2.8
Hypothyroidism (self reported)	1.1	2.4	3.7	1.9	1.1
Ever used hormone-replacement therapy (HRT)	1.1	1.3	2.4	0.5	1.6
Age when periods started (menarche)	1.1	2.6	4.6	0.8	2.1
Worrier / anxious feelings	1.1	2.1	3.9	2.0	-0.5
Hair/balding pattern: Pattern 3	1.1	1.6	3.2	-0.1	-1.8
Headache pain in last month	1.1	1.8	3.6	1.9	0.3
Exposure to tobacco smoke outside home	1.1	1.5	2.6	0.7	1.6
Medication: Blood pressure	1.1	1.9	2.2	1.5	1.2
Reaction Time	1.0	1.9	3.5	0.5	1.9
Age at First Birth	1.0	1.5	1.6	-1.2	-1.2
LDL Cholesterol	1.0	1.6	2.0	1.1	1.4
Rheumatoid Arthritis	1.0	1.4	2.3	0.6	1.5
Medication: Levothyroxine sodium	1.0	1.6	2.0	1.1	1.4
Diabetes (self-reported)	1.0	1.5	2.8	1.7	-0.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	5.6	-2.4	-1.1
Gout (self-reported)	1.0	1.4	2.0	-1.4	-0.9
Birth weight	1.0	2.1	4.1	0.4	-2.0
Pulse wave peak to peak time	1.0	1.2	2.3	-0.0	-1.5
Medication: Seretide 50 evohaler	1.0	1.1	2.0	-1.4	-0.4
Ever had bowel cancer screening	1.0	1.2	2.4	0.2	-1.5
Diabetes diagnosed by doctor	1.0	1.6	3.0	1.7	0.3
Eye problems/disorders: Cataract	1.0	1.2	1.3	-1.0	-1.2
Medication: Atorvastatin	1.0	1.2	2.4	-1.5	-0.3
Age started oral contraceptive pill	1.0	1.2	2.5	0.1	-1.6
Systolic blood pressure, automated reading	0.9	2.7	3.4	1.4	1.9
Nervous feelings	0.9	1.6	3.2	1.8	-0.1
Forced vital capacity (FVC)	0.9	3.6	5.8	-2.4	-1.2
Weight	0.9	4.5	4.6	2.1	2.1
Pulse rate	0.9	1.6	3.0	-1.7	0.4
Pulse wave Arterial Stiffness index	0.9	1.1	2.2	0.0	1.5
Peak expiratory flow (PEF)	0.9	2.1	3.5	-1.9	-0.8
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	2.9	1.7	0.8
Medication: Amlodipine	0.9	1.3	2.4	1.5	0.4
Smoking status: Previous	0.9	1.3	2.7	-0.1	1.6
Pain experienced in last month	0.9	1.5	2.5	-1.6	-0.7
Depression (Nagel 2018)	0.8	1.2	1.9	-1.4	-0.8
Neuroticism (2016)	0.8	1.2	1.3	-1.0	-1.1
Type 2 Diabetes (T2D) (2012)	0.8	1.0	1.0	0.9	1.0
Smoking Status	0.8	2.0	3.5	-0.7	1.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.6	0.4	-1.3
Chronic bronchitis/emphysema (father)	0.8	1.0	1.1	0.9	1.1
Neuroticism score	0.8	1.7	2.1	1.4	1.1
Medication: Omeprazole	0.8	1.0	1.8	0.3	1.4
Number of full sisters	0.8	1.0	2.0	0.3	1.4
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	1.3	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	0.9	-0.9	-0.9
Commuting to job workplace: Walk	0.8	0.8	0.9	-0.9	-0.9
Irritability	0.8	1.4	1.5	-1.1	-1.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	2.8	-1.7	-1.2
Worry (Nagel 2018)	0.7	1.5	2.8	0.5	-1.7
Crohns Disease (2012)	0.7	1.2	1.3	1.1	1.1
Blood Red Count	0.7	6.7	8.4	2.2	2.9
Multivitamins +/- minerals	0.7	0.9	1.2	0.8	1.1
Supplements: Glucosamine	0.7	0.9	1.3	1.1	0.7
Had other major operations	0.7	0.9	1.1	-0.8	-1.1
Medication: Ramipril	0.7	1.0	1.3	1.1	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.0	0.9	1.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.2	-0.6	-1.1
Back pain experienced in last month	0.7	1.0	1.9	0.3	1.4
Arm fat-free mass (left)	0.7	3.5	5.6	2.4	1.2
Average weekly beer plus cider intake	0.7	1.0	1.7	-0.6	1.3
Arm predicted mass (left)	0.7	3.4	5.6	2.4	1.1
Cardiovascular Disease	0.6	2.1	2.1	1.4	1.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	1.5	-0.2
Hair/balding pattern: Pattern 2	0.6	0.8	1.2	-1.1	-0.6
Mouth/teeth dental problems	0.6	0.9	1.1	-0.9	-1.1
Impedance of arm (left)	0.6	2.6	4.8	-2.2	-0.7
Birth weight of first child	0.6	1.0	1.6	0.7	-1.3
Glaucoma (self-reported)	0.6	0.7	1.3	1.1	0.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.3	1.2	0.4
Worry too long after embarrassment	0.6	0.9	1.4	1.2	0.7
Leg pain on walking	0.6	0.8	1.6	-0.0	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.1	0.4	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.0	-1.0	0.6
Ever smoked	0.6	1.1	2.3	-0.1	1.5
Alzheimer’s Disease (in father)	0.5	0.5	1.0	-0.3	1.0
Respiratory disease	0.5	1.0	2.0	-1.4	0.0
Angina	0.5	0.6	1.2	0.0	1.1
Impedance of leg (right)	0.5	2.5	4.6	0.6	2.1
Taking other prescription medications	0.5	0.8	1.5	1.2	0.4
Impedance of leg (left)	0.5	2.2	4.0	0.7	2.0
Financial difficulties in last 2 years	0.5	0.7	1.2	0.5	1.1
Falls in the last year	0.5	0.7	1.3	0.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.8	0.9	0.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	-0.0	1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.7	0.9	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	-1.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.8	0.6	0.9
Loneliness, isolation	0.5	0.7	1.4	0.1	1.2
Unable to work because of sickness or disability	0.5	0.7	1.3	0.3	1.2
Prostate Cancer	0.4	0.5	1.1	1.0	-0.1
Supplements: Zinc	0.4	0.5	0.8	0.9	-0.4
Serious illness, injury or assault to yourself	0.4	0.4	0.8	-0.1	0.9
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.1	1.1	0.8
Medication: Atenolol	0.4	0.5	0.9	1.0	0.2
Hip circumference	0.4	1.7	2.4	1.0	1.6
Exposure to tobacco smoke at home	0.4	0.4	0.5	0.7	0.6
Pulse wave reflection index	0.4	0.5	1.0	-1.0	-0.3
Wheeze or whistling in the chest in last year	0.4	0.7	1.0	0.7	1.0
Emphysema/chronic bronchitis	0.4	0.4	0.6	0.8	0.5
Heart disease (mother)	0.4	0.5	0.6	0.8	0.7
Family relationship satisfaction	0.4	0.5	0.9	-0.3	0.9
Mother’s age at death	0.4	0.5	0.7	0.9	0.5
High cholesterol (Self-reported)	0.4	0.7	1.3	0.4	1.1
Medication: Bendroflumethiazide	0.4	0.6	1.0	0.5	-1.0
Medication: Lisinopril	0.4	0.5	1.1	1.0	0.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	1.0	0.2
Alcohol drinker status: Previous	0.4	0.4	0.9	0.1	0.9
Bipolar Disorder (2018)	0.3	0.4	0.6	-0.8	0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.0	0.9
Ulcerative Colitis (UC)	0.3	0.6	1.3	-0.1	-1.1
Primary Biliary Cirrhosis	0.3	0.5	0.7	0.5	0.8
Heel T-Score	0.3	2.2	2.4	-1.4	1.6
Waist Hip Ratio (WHR)	0.3	1.3	2.5	-0.4	1.6
Systolic Blood Pressure	0.3	1.5	2.3	0.9	1.5
Hearing difficulty/problems: Yes	0.3	0.4	0.5	0.7	0.5
Medication: Metformin	0.3	0.5	0.9	0.9	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.9	-0.1
Sitting height	0.3	1.8	3.6	-0.1	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	0.2	1.1
Heart attack	0.3	0.4	0.5	0.5	0.7
Trunk fat-free mass	0.3	1.6	3.0	1.7	0.4
Happiness	0.3	0.3	0.6	0.8	-0.2
Trunk predicted mass	0.3	1.7	3.2	1.8	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.5	0.7	0.7
Angina (self-reported)	0.3	0.3	0.6	-0.3	0.8
Supplements: Vitamin C	0.3	0.4	0.4	0.7	0.6
Osteoporosis (self-reported)	0.3	0.4	0.7	0.8	0.4
Financial situation satisfaction	0.3	0.4	0.7	0.9	0.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.4	-0.7	0.6
Basal metabolic rate	0.3	1.5	2.7	1.6	0.6
Diastolic blood pressure, automated reading	0.3	0.9	1.7	-0.2	1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	-0.4	-0.7
Neuroticism (Nagel 2018)	0.2	0.4	0.5	0.7	-0.5
Ulcerative Colitis	0.2	0.3	0.4	0.3	-0.6
Blood White Count	0.2	1.1	1.6	0.8	1.2
Severe depression (siblings)	0.2	0.2	0.2	-0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.1	-1.1	0.0
High blood pressure	0.2	0.6	1.0	1.0	0.4
High blood pressure (mother)	0.2	0.3	0.4	0.6	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.4	-0.6	0.3
Had menopause	0.2	0.3	0.6	-0.1	-0.8
Allergy	0.2	0.5	0.8	-0.9	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.4	0.6	0.3
Medication: Lansoprazole	0.2	0.3	0.5	-0.3	-0.7
Lung cancer (father)	0.2	0.3	0.5	-0.7	-0.2
Tense / ‘highly strung’	0.2	0.3	0.6	0.8	-0.3
Arm fat-free mass (right)	0.2	1.2	2.3	1.5	0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.4	-0.4	0.6
Medication: Allopurinol	0.2	0.2	0.4	-0.6	-0.2
Arm predicted mass (right)	0.2	1.1	2.1	1.4	0.2
Pulse rate, automated reading	0.2	0.8	1.5	-1.2	-0.1
Medication: Aspirin	0.2	0.2	0.3	0.5	-0.4
Knee pain experienced in last month	0.2	0.4	0.5	0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.6	-0.8	0.2
Whole body fat-free mass	0.2	0.9	1.8	1.4	0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	0.5	0.6
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.7	-0.2
Medication: Aspirin	0.2	0.3	0.6	0.8	-0.1
Medication: Gliclazide	0.2	0.2	0.4	-0.2	-0.6
Whole body water mass	0.2	1.0	2.1	1.4	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.7	-0.1
Hearing aid user	0.2	0.2	0.4	0.6	-0.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	-0.4	-0.6
Number of operations (self-reported)	0.2	0.2	0.5	-0.7	-0.1
Risk taking	0.2	0.3	0.6	0.1	0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	0.4	0.5
Crohns Disease (2017)	0.1	0.3	0.5	0.7	0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.2	0.5	-0.4
Bipolar Disorder (2011)	0.1	0.1	0.2	0.0	-0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.3	0.4
HbA1C	0.1	0.1	0.1	0.3	0.2
Lupus	0.1	0.1	0.2	0.4	-0.1
Triglycerides	0.1	0.2	0.2	-0.5	0.5
Blood Platelet Count	0.1	1.5	1.8	-1.1	1.3
Height	0.1	1.7	3.0	0.7	-1.7
Lung FEV1/FVC ratio	0.1	0.7	0.8	-0.7	-0.9
Neuroticism	0.1	0.2	0.3	0.5	-0.3
Chronotype (morning person)	0.1	0.2	0.4	0.3	-0.6
Tanning	0.1	1.0	1.1	1.0	1.0
Medication for hormone replacement therapy	0.1	0.1	0.2	0.2	0.4
Hand grip strength (right)	0.1	0.2	0.3	0.2	0.6
Leg predicted mass (left)	0.1	0.3	0.5	0.7	-0.2
Pain all over the body in last month	0.1	0.1	0.2	-0.2	0.5
Impedance of arm (right)	0.1	0.6	1.0	-1.0	0.4
Asthma	0.1	0.2	0.3	-0.0	0.6
Length of working week for main job	0.1	0.1	0.2	-0.4	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.1	-0.4
Comparative body size at age 10	0.1	0.3	0.4	-0.5	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.1	0.3
Number of children fathered	0.1	0.1	0.2	-0.0	-0.4
Eye problems/disorders: None of the above	0.1	0.2	0.3	0.0	0.6
Comparative height size at age 10	0.1	0.7	1.0	1.0	-0.6
Suffer from ‘nerves’	0.1	0.2	0.4	0.6	-0.2
Had major operations	0.1	0.1	0.2	0.0	0.4
Hypertension (Self-reported)	0.1	0.2	0.3	0.6	0.1
Leg fat-free mass (right)	0.1	0.5	0.7	0.5	-0.8
Mood swings	0.1	0.2	0.2	0.4	0.4
Friendships satisfaction	0.1	0.1	0.1	-0.3	0.2
Breast cancer (self-reported)	0.1	0.1	0.1	-0.3	-0.4
Asthma (self-reported)	0.1	0.3	0.6	-0.0	0.8
Leg predicted mass (right)	0.1	0.4	0.7	0.4	-0.8
Medication: Blood pressure	0.1	0.1	0.2	0.4	-0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	-0.2	0.3
Fractured/broken bones in last 5 years	0.1	0.2	0.4	0.1	0.6
Commuting to job workplace: Cycle	0.1	0.1	0.3	-0.0	-0.5
Impedance of whole body	0.1	0.7	1.2	-1.1	0.4
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.1	-0.0
Allergy or Eczema	0.0	0.1	0.2	0.2	-0.4
Hair Pigment	0.0	0.4	0.6	-0.8	0.5
Hand grip strength (left)	0.0	0.0	0.0	-0.2	0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.2	-0.0
Leg fat-free mass (left)	0.0	0.3	0.5	0.7	-0.2
Fed-up feelings	0.0	0.1	0.1	0.0	0.4
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.2	0.2
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	0.1	0.1
Time employed in main current job	0.0	0.0	0.0	-0.1	-0.1
Standing height	0.0	0.5	0.6	0.7	-0.7
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.0	-0.3
Chest pain or discomfort	0.0	0.0	0.0	-0.2	0.1
Wears glasses or contact lenses	0.0	0.0	0.0	-0.0	-0.1
Supplements: Calcium	0.0	0.0	0.0	0.2	0.2

Hub : Genes

DPH2

Models

Trait associations