Best TWAS P=3.14e-12 · Best GWAS P=3.9e-13 conditioned to 0.824
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HYI | 0.38 | 0.09 | lasso | 9 | 0.07 | 1.6e-06 | -4.8 | -6.6 | 4.3e-11 | 0.54 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | ARTN | 0.13 | 0.08 | lasso | 3 | 0.07 | 2.4e-04 | -6.4 | -5.4 | 7.4e-08 | 0.39 | 0.10 | 0.74 | TRUE |
| 3 | GTEx | Brain Cerebellar Hemisphere | ARTN | 0.45 | 0.36 | enet | 29 | 0.40 | 2.5e-11 | -4.9 | -5.5 | 3.3e-08 | 0.48 | 0.80 | 0.15 | FALSE |
| 4 | GTEx | Brain Cerebellum | ARTN | 0.47 | 0.33 | lasso | 5 | 0.43 | 6.0e-14 | -5.1 | -6.7 | 2.0e-11 | 0.71 | 0.28 | 0.72 | FALSE |
| 5 | GTEx | Brain Cortex | ARTN | 0.13 | 0.04 | lasso | 5 | 0.03 | 5.9e-02 | -6.6 | -5.9 | 3.0e-09 | 0.87 | 0.09 | 0.62 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | ST3GAL3 | 0.03 | -0.01 | lasso | 2 | 0.01 | 1.6e-01 | -7.0 | -7.0 | 3.1e-12 | 0.43 | 0.04 | 0.16 | TRUE |
| 7 | GTEx | Heart Left Ventricle | MED8 | 0.08 | 0.01 | lasso | 3 | 0.01 | 1.2e-01 | 6.8 | -6.0 | 1.8e-09 | 0.35 | 0.18 | 0.11 | FALSE |
| 8 | GTEx | Lung | HYI | 0.18 | 0.04 | enet | 22 | 0.06 | 1.8e-05 | 3.4 | -5.5 | 4.3e-08 | 0.28 | 0.97 | 0.00 | FALSE |
| 9 | GTEx | Muscle Skeletal | B4GALT2 | 0.04 | 0.05 | lasso | 2 | 0.03 | 6.4e-04 | -6.4 | 6.3 | 2.4e-10 | -0.51 | 0.12 | 0.59 | FALSE |
| 10 | GTEx | Muscle Skeletal | ST3GAL3 | 0.10 | 0.01 | enet | 27 | 0.01 | 1.6e-02 | 6.8 | -5.9 | 4.1e-09 | 0.39 | 0.30 | 0.45 | TRUE |
| 11 | GTEx | Muscle Skeletal | RP11-7O11.3 | 0.05 | 0.02 | lasso | 3 | 0.02 | 7.2e-03 | -6.6 | 5.8 | 7.6e-09 | -0.65 | 0.08 | 0.53 | FALSE |
| 12 | GTEx | Nerve Tibial | MED8 | 0.13 | 0.07 | enet | 11 | 0.16 | 3.6e-11 | 3.3 | 6.0 | 1.4e-09 | -0.61 | 0.89 | 0.11 | TRUE |
| 13 | GTEx | Stomach | HYI | 0.16 | 0.06 | lasso | 6 | 0.07 | 4.1e-04 | -3.9 | -5.7 | 1.5e-08 | 0.56 | 0.35 | 0.21 | FALSE |
| 14 | GTEx | Thyroid | ARTN | 0.07 | 0.04 | lasso | 3 | 0.03 | 1.2e-03 | -6.6 | -5.7 | 1.0e-08 | 0.70 | 0.20 | 0.49 | FALSE |
| 15 | METSIM | Adipose | ARTN | 0.05 | 0.04 | bslmm | 412 | 0.03 | 1.3e-05 | -5.4 | -7.0 | 3.5e-12 | 0.71 | 0.36 | 0.63 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | ARTN | 0.14 | 0.19 | lasso | 4 | 0.18 | 3.0e-23 | -5.3 | -5.3 | 1.3e-07 | 0.36 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KIAA0467 | 0.07 | 0.03 | enet | 5 | 0.04 | 7.5e-05 | -4.8 | -5.5 | 3.4e-08 | 0.58 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | KDM4A | 0.03 | 0.02 | enet | 5 | 0.02 | 1.5e-03 | 1.8 | 5.5 | 3.4e-08 | -0.68 | 0.03 | 0.46 | FALSE |
| 19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ARTN | 0.08 | 0.10 | lasso | 1 | 0.08 | 3.7e-04 | -5.6 | -5.6 | 1.9e-08 | 0.41 | 0.03 | 0.75 | FALSE |
| 20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PTPRF | 0.07 | 0.01 | blup | 85 | 0.04 | 1.3e-02 | -5.5 | 5.8 | 6.2e-09 | -0.90 | 0.01 | 0.87 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DPH2 | 0.03 | 0.03 | enet | 7 | 0.04 | 5.8e-05 | -4.7 | -5.3 | 1.2e-07 | 0.53 | 0.20 | 0.64 | FALSE |