Best TWAS P=3.61e-18 · Best GWAS P=3.82e-20 conditioned to 0.00708
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | TNNT3 | 0.21 | -0.01 | enet | 17 | 0.00 | 6.4e-01 | 2.5 | 6.7 | 2.2e-11 | -0.30 | 0.05 | 0.06 | TRUE |
| 2 | GTEx | Brain Frontal Cortex BA9 | MRPL23-AS1 | 0.36 | 0.23 | lasso | 3 | 0.21 | 3.8e-06 | -5.7 | -5.8 | 6.9e-09 | 0.49 | 0.34 | 0.29 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | LSP1 | 0.21 | 0.04 | enet | 28 | 0.06 | 3.4e-05 | -9.2 | -6.6 | 3.0e-11 | 0.72 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | TNNT3 | 0.33 | 0.16 | lasso | 7 | 0.17 | 2.0e-09 | -7.8 | -8.2 | 2.4e-16 | 0.91 | 0.00 | 1.00 | FALSE |
| 5 | NTR | Blood | TNNT3 | 0.04 | 0.02 | blup | 461 | 0.02 | 4.3e-06 | -6.5 | 5.4 | 6.2e-08 | -0.66 | 0.09 | 0.90 | FALSE |
| 6 | YFS | Blood | TNNT3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.9e-05 | -7.8 | 6.9 | 5.5e-12 | -0.81 | 0.04 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LSP1 | 0.12 | 0.08 | lasso | 5 | 0.10 | 5.0e-11 | 8.1 | 8.7 | 3.6e-18 | -0.60 | 0.05 | 0.95 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LSP1 | 0.06 | 0.04 | enet | 6 | 0.04 | 3.1e-05 | -6.9 | -6.3 | 3.6e-10 | 0.11 | 0.63 | 0.07 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LOC100133545 | 0.03 | 0.01 | blup | 49 | 0.01 | 1.1e-02 | -4.5 | -5.3 | 1.4e-07 | 0.39 | 0.00 | 0.45 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LSP1 | 0.07 | 0.03 | lasso | 4 | 0.03 | 2.4e-04 | -6.9 | 8.4 | 5.3e-17 | -0.35 | 0.09 | 0.25 | FALSE |
| 11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TNNI2 | 0.11 | 0.09 | lasso | 2 | 0.08 | 4.1e-06 | -6.9 | 6.9 | 4.3e-12 | -0.19 | 0.60 | 0.07 | FALSE |