Best TWAS P=1.34e-10 · Best GWAS P=1.34e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C11orf1 | 0.06 | 0.06 | lasso | 5 | 0.05 | 4.4e-07 | -5.2 | 5.2 | 2.1e-07 | -0.76 | 0.45 | 0.55 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | LAYN | 0.24 | 0.12 | lasso | 7 | 0.13 | 6.2e-04 | -4.8 | 5.3 | 1.1e-07 | -0.81 | 0.11 | 0.49 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SIK2 | 0.13 | 0.03 | lasso | 4 | 0.02 | 2.2e-02 | -5.3 | -5.8 | 7.0e-09 | 0.91 | 0.09 | 0.70 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | CRYAB | 0.07 | 0.04 | lasso | 10 | 0.02 | 1.3e-02 | -5.2 | -5.2 | 2.3e-07 | 0.73 | 0.12 | 0.74 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | C11orf1 | 0.06 | 0.05 | lasso | 2 | 0.02 | 9.6e-03 | -5.2 | 5.2 | 2.2e-07 | -0.73 | 0.23 | 0.51 | FALSE |
| 6 | GTEx | Testis | PPP2R1B | 0.34 | 0.21 | lasso | 10 | 0.36 | 1.5e-16 | -6.2 | 5.3 | 1.2e-07 | -0.81 | 0.06 | 0.94 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LAYN | 0.02 | 0.03 | blup | 33 | 0.03 | 3.7e-06 | -4.9 | -5.4 | 5.6e-08 | 0.80 | 0.15 | 0.84 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIK2 | 0.04 | 0.01 | blup | 35 | 0.01 | 6.7e-03 | -6.4 | -5.7 | 1.0e-08 | 0.95 | 0.01 | 0.95 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LAYN | 0.13 | 0.07 | enet | 8 | 0.07 | 9.9e-04 | -4.8 | -5.6 | 2.5e-08 | 0.68 | 0.02 | 0.71 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIK2 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.6e-06 | -6.4 | -6.4 | 1.3e-10 | 1.00 | 0.00 | 1.00 | TRUE |