[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr11:110,721,187-112,491,227

Best TWAS P=1.34e-10 · Best GWAS P=1.34e-10 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	The Cancer Genome Atlas	Prostate Adenocarcinoma	SIK2	0.05	0.06	lasso	1	0.05	2.6e-06	-6.4	-6.4	1.3e-10	1.00	0.00	1.00	TRUE
3	GTEx	Esophagus Mucosa	SIK2	0.13	0.03	lasso	4	0.02	2.2e-02	-5.3	-5.8	7.0e-09	0.91	0.09	0.70	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	SIK2	0.04	0.01	blup	35	0.01	6.7e-03	-6.4	-5.7	1.0e-08	0.95	0.01	0.95	FALSE
9	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LAYN	0.13	0.07	enet	8	0.07	9.9e-04	-4.8	-5.6	2.5e-08	0.68	0.02	0.71	FALSE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	LAYN	0.02	0.03	blup	33	0.03	3.7e-06	-4.9	-5.4	5.6e-08	0.80	0.15	0.84	FALSE
2	GTEx	Brain Putamen basal ganglia	LAYN	0.24	0.12	lasso	7	0.13	6.2e-04	-4.8	5.3	1.1e-07	-0.81	0.11	0.49	FALSE
6	GTEx	Testis	PPP2R1B	0.34	0.21	lasso	10	0.36	1.5e-16	-6.2	5.3	1.2e-07	-0.81	0.06	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C11orf1	0.06	0.06	lasso	5	0.05	4.4e-07	-5.2	5.2	2.1e-07	-0.76	0.45	0.55	FALSE
5	GTEx	Skin Sun Exposed Lower leg	C11orf1	0.06	0.05	lasso	2	0.02	9.6e-03	-5.2	5.2	2.2e-07	-0.73	0.23	0.51	FALSE
4	GTEx	Skin Sun Exposed Lower leg	CRYAB	0.07	0.04	lasso	10	0.02	1.3e-02	-5.2	-5.2	2.3e-07	0.73	0.12	0.74	FALSE