Best TWAS P=9.99e-13 · Best GWAS P=6.74e-08 conditioned to 0.546
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Left Ventricle | KREMEN1 | 0.47 | 0.32 | lasso | 6 | 0.34 | 5.0e-19 | -5.3 | -5.3 | 1.3e-07 | 0.95 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Ovary | KREMEN1 | 0.28 | 0.18 | enet | 5 | 0.19 | 1.7e-05 | -5.3 | -5.3 | 9.8e-08 | 0.84 | 0.01 | 0.92 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C22orf31 | 0.04 | 0.02 | blup | 67 | 0.01 | 2.6e-03 | -4.3 | 5.1 | 3.0e-07 | -0.11 | 0.16 | 0.20 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KREMEN1 | 0.13 | 0.10 | lasso | 5 | 0.11 | 3.3e-12 | -5.3 | -5.7 | 1.5e-08 | 0.93 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC117 | 0.03 | 0.01 | blup | 41 | 0.01 | 2.3e-02 | 4.1 | -5.4 | 8.5e-08 | 0.10 | 0.01 | 0.63 | FALSE |
| 6 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | ZNRF3 | 0.44 | -0.01 | blup | 126 | 0.05 | 2.0e-02 | 1.1 | -7.1 | 1.0e-12 | 0.61 | 0.01 | 0.13 | TRUE |