Best TWAS P=2.31e-10 · Best GWAS P=6.15e-11 conditioned to 0.00785
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SF3B1 | 0.06 | 0.07 | enet | 10 | 0.07 | 2.5e-09 | -5.8 | -5.8 | 7.4e-09 | 0.51 | 0.10 | 0.90 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | SF3B1 | 0.06 | 0.06 | lasso | 4 | 0.03 | 6.6e-03 | -5.7 | -6.1 | 1.3e-09 | 0.64 | 0.11 | 0.79 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | SF3B1 | 0.05 | -0.01 | lasso | 3 | -0.01 | 8.1e-01 | -5.7 | -5.8 | 8.3e-09 | 0.68 | 0.05 | 0.22 | FALSE |
| 4 | GTEx | Esophagus Mucosa | SF3B1 | 0.04 | 0.02 | lasso | 4 | 0.01 | 5.7e-02 | -5.6 | -5.5 | 3.3e-08 | 0.51 | 0.12 | 0.65 | FALSE |
| 5 | GTEx | Esophagus Muscularis | SF3B1 | 0.06 | 0.02 | lasso | 4 | 0.03 | 1.0e-02 | -5.6 | -5.9 | 4.7e-09 | 0.45 | 0.10 | 0.55 | FALSE |
| 6 | GTEx | Lung | RFTN2 | 0.06 | 0.08 | lasso | 8 | 0.06 | 2.7e-05 | -6.0 | -5.8 | 7.0e-09 | 0.91 | 0.19 | 0.80 | FALSE |
| 7 | GTEx | Nerve Tibial | SF3B1 | 0.06 | 0.09 | lasso | 8 | 0.08 | 3.3e-06 | -5.7 | -5.9 | 3.3e-09 | 0.57 | 0.09 | 0.91 | FALSE |
| 8 | GTEx | Pituitary | HSPD1 | 0.10 | 0.03 | enet | 12 | 0.06 | 1.3e-02 | -3.5 | -5.8 | 4.9e-09 | 0.48 | 0.07 | 0.42 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | MARS2 | 0.04 | 0.05 | enet | 8 | 0.03 | 1.2e-03 | -5.4 | 5.6 | 2.2e-08 | -0.91 | 0.16 | 0.83 | FALSE |
| 10 | GTEx | Spleen | RFTN2 | 0.11 | 0.03 | enet | 26 | 0.05 | 2.4e-02 | -5.3 | -5.7 | 1.1e-08 | 0.88 | 0.09 | 0.34 | FALSE |
| 11 | GTEx | Spleen | MARS2 | 0.12 | 0.04 | lasso | 5 | 0.00 | 3.4e-01 | -5.5 | 5.2 | 2.3e-07 | -0.86 | 0.06 | 0.40 | FALSE |
| 12 | GTEx | Testis | SF3B1 | 0.10 | 0.07 | enet | 17 | 0.08 | 2.6e-04 | -5.8 | -5.3 | 1.4e-07 | 0.57 | 0.14 | 0.84 | FALSE |
| 13 | GTEx | Thyroid | SF3B1 | 0.04 | 0.02 | enet | 14 | 0.02 | 2.0e-02 | -5.8 | -6.3 | 2.3e-10 | 0.76 | 0.07 | 0.86 | TRUE |
| 14 | GTEx | Thyroid | PLCL1 | 0.04 | 0.01 | lasso | 4 | 0.00 | 2.6e-01 | -5.1 | -5.7 | 1.5e-08 | 0.81 | 0.12 | 0.68 | FALSE |
| 15 | GTEx | Whole Blood | PLCL1 | 0.08 | 0.08 | enet | 15 | 0.05 | 4.1e-05 | -6.0 | -6.0 | 2.6e-09 | 0.97 | 0.01 | 0.99 | FALSE |
| 16 | NTR | Blood | ANKRD44 | 0.03 | 0.00 | bslmm | 417 | 0.02 | 2.7e-06 | -4.9 | 5.3 | 1.2e-07 | -0.50 | 0.15 | 0.74 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | SF3B1 | 0.02 | 0.01 | blup | 336 | 0.01 | 6.2e-03 | -5.8 | -5.4 | 5.3e-08 | 0.52 | 0.09 | 0.85 | FALSE |
| 18 | YFS | Blood | ANKRD44 | 0.02 | 0.00 | blup | 416 | 0.01 | 6.3e-04 | -2.0 | 5.5 | 3.6e-08 | -0.40 | 0.11 | 0.60 | FALSE |
| 19 | YFS | Blood | PLCL1 | 0.10 | 0.10 | lasso | 9 | 0.14 | 1.5e-43 | -6.5 | -5.9 | 2.9e-09 | 0.88 | 0.01 | 0.99 | FALSE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RFTN2 | 0.05 | 0.01 | blup | 61 | 0.02 | 3.1e-02 | -5.8 | -6.2 | 6.9e-10 | 0.74 | 0.02 | 0.60 | FALSE |