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chr2:197,134,790-200,117,777

Best TWAS P=2.31e-10 · Best GWAS P=6.15e-11 conditioned to 0.00785

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Thyroid	SF3B1	0.04	0.02	enet	14	0.02	2.0e-02	-5.8	-6.3	2.3e-10	0.76	0.07	0.86	TRUE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFTN2	0.05	0.01	blup	61	0.02	3.1e-02	-5.8	-6.2	6.9e-10	0.74	0.02	0.60	FALSE
2	GTEx	Breast Mammary Tissue	SF3B1	0.06	0.06	lasso	4	0.03	6.6e-03	-5.7	-6.1	1.3e-09	0.64	0.11	0.79	FALSE
15	GTEx	Whole Blood	PLCL1	0.08	0.08	enet	15	0.05	4.1e-05	-6.0	-6.0	2.6e-09	0.97	0.01	0.99	FALSE
19	YFS	Blood	PLCL1	0.10	0.10	lasso	9	0.14	1.5e-43	-6.5	-5.9	2.9e-09	0.88	0.01	0.99	FALSE
7	GTEx	Nerve Tibial	SF3B1	0.06	0.09	lasso	8	0.08	3.3e-06	-5.7	-5.9	3.3e-09	0.57	0.09	0.91	FALSE
5	GTEx	Esophagus Muscularis	SF3B1	0.06	0.02	lasso	4	0.03	1.0e-02	-5.6	-5.9	4.7e-09	0.45	0.10	0.55	FALSE
8	GTEx	Pituitary	HSPD1	0.10	0.03	enet	12	0.06	1.3e-02	-3.5	-5.8	4.9e-09	0.48	0.07	0.42	FALSE
6	GTEx	Lung	RFTN2	0.06	0.08	lasso	8	0.06	2.7e-05	-6.0	-5.8	7.0e-09	0.91	0.19	0.80	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SF3B1	0.06	0.07	enet	10	0.07	2.5e-09	-5.8	-5.8	7.4e-09	0.51	0.10	0.90	FALSE
3	GTEx	Breast Mammary Tissue (Female)	SF3B1	0.05	-0.01	lasso	3	-0.01	8.1e-01	-5.7	-5.8	8.3e-09	0.68	0.05	0.22	FALSE
10	GTEx	Spleen	RFTN2	0.11	0.03	enet	26	0.05	2.4e-02	-5.3	-5.7	1.1e-08	0.88	0.09	0.34	FALSE
14	GTEx	Thyroid	PLCL1	0.04	0.01	lasso	4	0.00	2.6e-01	-5.1	-5.7	1.5e-08	0.81	0.12	0.68	FALSE
9	GTEx	Skin Sun Exposed Lower leg	MARS2	0.04	0.05	enet	8	0.03	1.2e-03	-5.4	5.6	2.2e-08	-0.91	0.16	0.83	FALSE
4	GTEx	Esophagus Mucosa	SF3B1	0.04	0.02	lasso	4	0.01	5.7e-02	-5.6	-5.5	3.3e-08	0.51	0.12	0.65	FALSE
18	YFS	Blood	ANKRD44	0.02	0.00	blup	416	0.01	6.3e-04	-2.0	5.5	3.6e-08	-0.40	0.11	0.60	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	SF3B1	0.02	0.01	blup	336	0.01	6.2e-03	-5.8	-5.4	5.3e-08	0.52	0.09	0.85	FALSE
16	NTR	Blood	ANKRD44	0.03	0.00	bslmm	417	0.02	2.7e-06	-4.9	5.3	1.2e-07	-0.50	0.15	0.74	FALSE
12	GTEx	Testis	SF3B1	0.10	0.07	enet	17	0.08	2.6e-04	-5.8	-5.3	1.4e-07	0.57	0.14	0.84	FALSE
11	GTEx	Spleen	MARS2	0.12	0.04	lasso	5	0.00	3.4e-01	-5.5	5.2	2.3e-07	-0.86	0.06	0.40	FALSE