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chr2:101,994,731-104,027,106

Best TWAS P=1.24e-84 · Best GWAS P=2.42e-72 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL1RL1	0.08	0.08	enet	9	0.08	1.2e-09	18.0	19.5	1.2e-84	0.95	0.00	1.00	TRUE
24	The Cancer Genome Atlas	Thyroid Carcinoma	IL1RL1	0.05	0.03	enet	6	0.03	9.7e-04	18.0	18.2	1.2e-73	0.98	0.00	0.99	TRUE
9	YFS	Blood	IL18RAP	0.41	0.55	bslmm	562	0.62	4.2e-269	-11.1	7.8	7.4e-15	0.32	1.00	0.00	TRUE
3	CommonMind	Brain Pre-frontal Cortex	SLC9A2	0.17	0.10	lasso	4	0.11	4.7e-13	-7.1	-7.2	4.9e-13	-0.23	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	IL1R1	0.14	0.09	lasso	3	0.10	4.0e-12	6.6	-6.9	6.4e-12	-0.15	1.00	0.00	TRUE
25	The Cancer Genome Atlas	Thyroid Carcinoma	SLC9A2	0.05	0.01	blup	93	0.02	8.6e-03	-6.3	-6.6	5.4e-11	-0.17	0.11	0.04	TRUE
13	The Cancer Genome Atlas	Glioblastoma Multiforme	IL18RAP	0.34	0.02	blup	94	0.08	1.5e-03	1.2	5.7	1.6e-08	-0.01	0.02	0.06	TRUE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	IL1RL1	0.03	0.01	blup	78	0.02	4.7e-03	17.3	19.2	3.5e-82	0.84	0.01	0.94	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL1RL1	0.04	0.04	lasso	8	0.04	1.7e-05	17.8	18.9	6.0e-80	0.91	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IL1RL1	0.18	0.06	blup	78	0.15	3.7e-09	-13.8	18.7	2.8e-78	0.83	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IL1RL1	0.19	0.05	blup	78	0.10	7.1e-05	-14.0	17.6	1.4e-69	0.62	0.11	0.72	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	IL1RL1	0.02	0.01	blup	78	0.01	1.5e-03	-13.8	16.0	1.2e-57	0.63	0.16	0.22	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL18RAP	0.03	0.02	blup	94	0.02	1.2e-03	14.6	-15.6	4.6e-55	-0.61	0.02	0.73	FALSE
10	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL1RL1	0.04	0.03	lasso	7	0.03	8.1e-04	14.6	15.4	1.7e-53	0.50	0.24	0.12	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL1RL2	0.04	0.04	enet	5	0.03	1.9e-04	13.8	13.8	1.9e-43	0.70	0.06	0.41	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	IL1RL2	0.08	0.02	enet	33	0.03	2.3e-04	-9.1	12.9	4.5e-38	0.48	0.17	0.18	FALSE
4	GTEx	Colon Transverse	IL18R1	0.14	0.00	enet	41	0.00	2.1e-01	-4.1	-11.9	1.9e-32	-0.40	0.04	0.48	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	IL1R1	0.36	0.19	enet	28	0.23	1.1e-23	13.0	-9.8	8.4e-23	-0.51	0.32	0.68	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	IL18R1	0.05	0.01	blup	108	0.03	1.8e-07	14.6	-9.2	4.4e-20	-0.08	0.99	0.00	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL18R1	0.06	0.01	blup	108	0.04	2.6e-05	1.3	8.8	1.6e-18	0.63	0.01	0.86	FALSE
5	GTEx	Whole Blood	IL18R1	0.06	0.00	enet	14	0.01	2.1e-02	14.6	-8.2	3.7e-16	-0.24	0.17	0.05	FALSE
6	NTR	Blood	IL18R1	0.05	0.02	bslmm	582	0.02	5.1e-07	-5.3	-6.9	5.6e-12	-0.29	0.99	0.00	FALSE
7	NTR	Blood	IL18RAP	0.14	0.16	lasso	7	0.19	1.1e-59	-11.1	6.8	9.8e-12	0.26	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IL1RL2	0.18	0.05	bslmm	549	0.09	1.8e-11	11.3	6.0	2.5e-09	0.26	1.00	0.00	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL1R2	0.03	0.01	blup	87	0.02	2.5e-03	-5.1	5.1	3.1e-07	0.14	0.06	0.13	FALSE