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chr4:38,079,294-39,824,758

Best TWAS P=3.5e-58 · Best GWAS P=6.66e-60 conditioned to 0.0044

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TLR1	0.08	0.07	lasso	2	0.07	1.3e-08	14.690	15.4	1.4e-53	0.88	0.23	0.77	FALSE
2	GTEx	Adipose Subcutaneous	FAM114A1	0.21	0.17	lasso	5	0.17	9.5e-14	0.754	6.1	1.0e-09	0.37	1.00	0.00	FALSE
3	GTEx	Artery Coronary	RP11-360F5.3	0.21	0.11	enet	32	0.00	4.2e-01	0.011	5.8	8.3e-09	0.40	0.18	0.30	FALSE
4	GTEx	Breast Mammary Tissue	FAM114A1	0.11	0.04	lasso	3	0.05	1.0e-03	14.692	10.2	1.2e-24	0.63	0.24	0.33	TRUE
5	GTEx	Breast Mammary Tissue (Female)	FAM114A1	0.07	-0.01	lasso	4	0.01	1.7e-01	3.992	6.7	1.6e-11	0.50	0.04	0.16	FALSE
6	GTEx	Cells Transformed fibroblasts	TLR6	0.28	0.19	lasso	5	0.17	1.7e-12	13.545	-13.7	8.4e-43	-0.76	1.00	0.00	FALSE
7	GTEx	Esophagus Mucosa	TLR1	0.20	0.02	lasso	6	0.04	9.8e-04	13.545	-14.7	3.8e-49	-0.88	0.02	0.97	FALSE
8	GTEx	Esophagus Mucosa	FAM114A1	0.14	0.03	lasso	11	0.03	6.6e-03	-6.821	10.1	5.0e-24	0.53	0.63	0.21	FALSE
9	GTEx	Esophagus Muscularis	TLR1	0.21	0.02	enet	46	0.06	2.3e-04	11.820	-9.9	3.0e-23	-0.54	0.06	0.83	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	TLR6	0.29	0.03	lasso	11	0.08	4.8e-05	-5.760	-12.7	4.8e-37	-0.65	0.67	0.21	FALSE
11	GTEx	Skin Sun Exposed Lower leg	TLR6	0.17	0.12	lasso	7	0.10	1.6e-08	-5.760	-8.8	1.3e-18	-0.41	1.00	0.00	FALSE
12	GTEx	Testis	FAM114A1	0.37	0.20	lasso	7	0.20	2.2e-09	14.785	13.7	9.5e-43	0.79	0.63	0.35	FALSE
13	NTR	Blood	TLR1	0.03	0.00	bslmm	520	0.01	3.0e-03	15.370	-9.5	2.3e-21	-0.56	0.06	0.49	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	TLR10	0.08	0.01	blup	517	0.03	3.4e-05	5.730	-7.8	8.0e-15	-0.58	0.63	0.21	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	TLR1	0.08	0.02	blup	514	0.03	2.3e-05	14.201	12.9	6.9e-38	0.68	0.04	0.96	FALSE
16	YFS	Blood	TLR1	0.08	0.05	bslmm	525	0.07	1.2e-20	16.028	-12.9	7.0e-38	-0.80	0.18	0.82	FALSE
17	YFS	Blood	TLR6	0.05	0.04	bslmm	505	0.06	1.3e-18	14.637	-13.3	3.5e-40	-0.79	0.98	0.02	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TLR6	0.03	0.02	lasso	2	0.01	3.5e-02	13.545	-13.5	1.3e-41	-0.75	0.06	0.09	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TLR1	0.04	0.03	lasso	4	0.03	8.2e-05	15.370	-16.1	3.5e-58	-0.92	0.01	0.99	TRUE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TLR10	0.09	0.06	lasso	2	0.06	2.3e-04	10.811	-10.8	2.3e-27	-0.57	0.16	0.06	FALSE
21	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TLR1	0.14	0.07	enet	12	0.10	1.7e-05	14.201	-14.4	5.6e-47	-0.81	0.24	0.70	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TLR1	0.03	0.03	enet	23	0.03	1.5e-04	15.370	-11.0	6.4e-28	-0.69	0.04	0.87	FALSE
23	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TLR1	0.08	0.02	enet	11	0.04	1.1e-03	9.340	-5.2	1.5e-07	-0.32	0.02	0.05	FALSE
24	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TLR6	0.10	0.13	lasso	1	0.10	4.4e-05	-5.760	-5.8	8.4e-09	-0.23	0.37	0.03	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	TLR6	0.07	0.02	blup	65	0.01	4.7e-02	-6.943	6.2	5.4e-10	0.52	0.08	0.07	FALSE
26	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TLR1	0.13	0.13	enet	3	0.08	2.6e-03	9.806	-12.2	2.6e-34	-0.79	0.01	0.74	FALSE