[Hub]/) : Traits : Allergy :

chr4:38,079,294-39,824,758

Best TWAS P=3.5e-58 · Best GWAS P=6.66e-60 conditioned to 0.0044

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TLR1 0.08 0.07 lasso 2 0.07 1.3e-08 14.690 15.4 1.4e-53 0.88 0.23 0.77 FALSE
2 GTEx Adipose Subcutaneous FAM114A1 0.21 0.17 lasso 5 0.17 9.5e-14 0.754 6.1 1.0e-09 0.37 1.00 0.00 FALSE
3 GTEx Artery Coronary RP11-360F5.3 0.21 0.11 enet 32 0.00 4.2e-01 0.011 5.8 8.3e-09 0.40 0.18 0.30 FALSE
4 GTEx Breast Mammary Tissue FAM114A1 0.11 0.04 lasso 3 0.05 1.0e-03 14.692 10.2 1.2e-24 0.63 0.24 0.33 TRUE
5 GTEx Breast Mammary Tissue (Female) FAM114A1 0.07 -0.01 lasso 4 0.01 1.7e-01 3.992 6.7 1.6e-11 0.50 0.04 0.16 FALSE
6 GTEx Cells Transformed fibroblasts TLR6 0.28 0.19 lasso 5 0.17 1.7e-12 13.545 -13.7 8.4e-43 -0.76 1.00 0.00 FALSE
7 GTEx Esophagus Mucosa TLR1 0.20 0.02 lasso 6 0.04 9.8e-04 13.545 -14.7 3.8e-49 -0.88 0.02 0.97 FALSE
8 GTEx Esophagus Mucosa FAM114A1 0.14 0.03 lasso 11 0.03 6.6e-03 -6.821 10.1 5.0e-24 0.53 0.63 0.21 FALSE
9 GTEx Esophagus Muscularis TLR1 0.21 0.02 enet 46 0.06 2.3e-04 11.820 -9.9 3.0e-23 -0.54 0.06 0.83 FALSE
10 GTEx Skin Not Sun Exposed Suprapubic TLR6 0.29 0.03 lasso 11 0.08 4.8e-05 -5.760 -12.7 4.8e-37 -0.65 0.67 0.21 FALSE
11 GTEx Skin Sun Exposed Lower leg TLR6 0.17 0.12 lasso 7 0.10 1.6e-08 -5.760 -8.8 1.3e-18 -0.41 1.00 0.00 FALSE
12 GTEx Testis FAM114A1 0.37 0.20 lasso 7 0.20 2.2e-09 14.785 13.7 9.5e-43 0.79 0.63 0.35 FALSE
13 NTR Blood TLR1 0.03 0.00 bslmm 520 0.01 3.0e-03 15.370 -9.5 2.3e-21 -0.56 0.06 0.49 FALSE
14 ROSMAP Brain Pre-frontal Cortex TLR10 0.08 0.01 blup 517 0.03 3.4e-05 5.730 -7.8 8.0e-15 -0.58 0.63 0.21 FALSE
15 ROSMAP Brain Pre-frontal Cortex TLR1 0.08 0.02 blup 514 0.03 2.3e-05 14.201 12.9 6.9e-38 0.68 0.04 0.96 FALSE
16 YFS Blood TLR1 0.08 0.05 bslmm 525 0.07 1.2e-20 16.028 -12.9 7.0e-38 -0.80 0.18 0.82 FALSE
17 YFS Blood TLR6 0.05 0.04 bslmm 505 0.06 1.3e-18 14.637 -13.3 3.5e-40 -0.79 0.98 0.02 FALSE
18 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TLR6 0.03 0.02 lasso 2 0.01 3.5e-02 13.545 -13.5 1.3e-41 -0.75 0.06 0.09 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TLR1 0.04 0.03 lasso 4 0.03 8.2e-05 15.370 -16.1 3.5e-58 -0.92 0.01 0.99 TRUE
20 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TLR10 0.09 0.06 lasso 2 0.06 2.3e-04 10.811 -10.8 2.3e-27 -0.57 0.16 0.06 FALSE
21 The Cancer Genome Atlas Liver Hepatocellular Carcinoma TLR1 0.14 0.07 enet 12 0.10 1.7e-05 14.201 -14.4 5.6e-47 -0.81 0.24 0.70 FALSE
22 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TLR1 0.03 0.03 enet 23 0.03 1.5e-04 15.370 -11.0 6.4e-28 -0.69 0.04 0.87 FALSE
23 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TLR1 0.08 0.02 enet 11 0.04 1.1e-03 9.340 -5.2 1.5e-07 -0.32 0.02 0.05 FALSE
24 The Cancer Genome Atlas Pancreatic Adenocarcinoma TLR6 0.10 0.13 lasso 1 0.10 4.4e-05 -5.760 -5.8 8.4e-09 -0.23 0.37 0.03 FALSE
25 The Cancer Genome Atlas Prostate Adenocarcinoma TLR6 0.07 0.02 blup 65 0.01 4.7e-02 -6.943 6.2 5.4e-10 0.52 0.08 0.07 FALSE
26 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma TLR1 0.13 0.13 enet 3 0.08 2.6e-03 9.806 -12.2 2.6e-34 -0.79 0.01 0.74 FALSE