Hub : Genes

WNT11

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.188	0.0784	0.00960	-0.007	NA	-0.003	NA	-0.005	6.8e-01	NA	0.45000	NA	0.56000
2	GTEx	Esophagus Mucosa	0.237	0.0690	0.00120	0.000	NA	0.018	NA	0.005	3.0e-01	NA	0.02200	NA	0.13000
3	GTEx	Spleen	0.425	0.0970	0.00035	0.199	NA	0.145	NA	0.136	8.1e-06	NA	0.00015	NA	0.00024
4	GTEx	Whole Blood	0.105	0.0350	0.00180	0.006	NA	0.031	NA	0.023	7.6e-02	NA	0.00073	NA	0.00300

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.0	3.3	-0.2	1.8	-0.8	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.7	0.1	1.3	-1.0	0.2
Depressed Affect (Nagel 2018)	0.3	0.6	1.9	0.3	0.3	0.4	-1.4
Depression (Nagel 2018)	2.2	3.3	7.3	-1.1	1.1	-1.9	-2.7
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.8	1.3	0.6	1.9	1.0
Neuroticism (Nagel 2018)	0.1	0.3	1.3	0.3	0.1	0.1	-1.1
Schizophrenia (2018)	0.1	0.2	0.4	0.4	0.4	-0.7	0.5
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	0.2	-0.5	-1.1	-1.2
Worry (Nagel 2018)	0.2	0.4	0.9	-0.2	0.1	-0.9	-0.9
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.5	0.1	0.1	-0.0
Alzheimer’s Disease (in father)	1.3	1.4	2.2	1.5	1.1	1.4	0.6
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	0.9	0.4	1.1	0.5
Crohns Disease (2017)	0.5	1.2	3.2	-0.6	-1.8	-0.5	-0.9
Irritable Bowel Disease (IBD)	0.6	1.4	4.3	-0.4	-0.7	-0.6	-2.1
Ulcerative Colitis (UC)	1.1	2.1	7.5	-0.1	0.6	-0.6	-2.7
Major Depression (MDD)	1.9	2.4	3.3	1.8	1.6	1.5	-1.1
Reaction Time	0.3	0.6	1.2	-0.5	1.1	-0.6	0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.3	0.6	-0.6	1.5	1.4
Breast Cancer	0.1	0.3	0.8	0.9	0.3	0.2	0.6
Ovarian Cancer	1.4	1.9	3.1	-0.3	-1.2	-1.8	-1.7
Prostate Cancer	0.6	0.8	2.2	-0.3	0.2	-0.9	-1.5
Age at First Birth	0.0	0.0	0.1	0.1	-0.3	0.1	0.1
Bipolar Disorder (2011)	1.3	1.2	3.8	0.6	1.9	-0.9	-0.1
Body Mass Index (BMI) (2010)	0.4	0.6	0.8	-0.7	-0.9	0.9	0.6
Coronary Artery Disease (CAD)	1.0	1.2	2.5	1.4	0.6	1.6	0.4
Crohns Disease (2012)	0.6	1.0	1.7	1.2	-1.3	0.4	-0.9
Mean Putamen Volume	0.5	0.6	1.6	0.6	0.6	-0.2	-1.3
Fasting Glucose	0.2	0.3	0.5	0.6	0.7	0.1	-0.4
HbA1C	0.9	0.9	3.4	1.8	0.0	0.6	0.2
HDL Cholesterol	0.3	0.5	0.9	0.7	0.8	-1.0	-0.3
LDL Cholesterol	0.7	1.1	1.4	-1.0	-0.9	-1.2	-1.0
Lupus	0.4	0.5	1.0	0.5	1.0	-0.8	-0.4
Neuroticism (2016)	0.9	1.2	3.7	0.5	1.9	1.0	0.1
Primary Biliary Cirrhosis	2.2	3.1	7.2	-1.3	0.2	-2.7	-1.9
Rheumatoid Arthritis	0.8	1.2	4.2	0.1	-2.1	-0.3	-0.6
Schizophrenia (2014)	0.3	0.7	1.3	0.7	1.0	-1.1	-0.2
Triglycerides	0.1	0.1	0.3	0.2	-0.2	-0.5	-0.1
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.1	-0.1	-1.8	0.0	-1.1
Ulcerative Colitis	1.6	2.4	8.3	-0.9	0.5	-0.3	-2.9
Blood Eosinophil Count	0.9	6.7	15.8	-2.7	-0.7	-1.8	-4.0
Blood Platelet Count	0.8	8.8	17.2	-1.7	-0.3	-4.2	-3.9
Blood Red Count	0.2	1.7	5.1	-2.2	-1.0	-0.2	-0.8
Blood White Count	0.3	2.4	4.0	-2.0	-1.4	-1.8	-0.8
Heel T-Score	0.3	2.2	5.8	2.4	1.5	-0.8	-0.4
BMI	0.1	0.3	0.6	0.8	-0.3	0.7	-0.3
Height	0.2	3.7	4.8	-1.7	1.7	2.2	2.0
Waist Hip Ratio (WHR)	0.1	0.6	2.2	0.5	-0.3	1.5	0.1
Systolic Blood Pressure	0.3	1.4	2.4	-1.5	1.0	-1.6	-0.2
Smoking Status	0.2	0.4	1.3	0.2	-0.1	0.4	-1.1
Allergy or Eczema	3.9	10.2	23.2	-3.6	0.2	-2.1	-4.8
Cardiovascular Disease	0.7	2.4	3.8	-1.4	-0.9	-1.9	-1.8
Hypothyroidism (self reported)	0.3	0.7	2.3	0.1	-1.5	0.1	0.7
Respiratory disease	3.9	8.7	14.4	-3.8	-0.6	-2.7	-3.5
Type 2 Diabetes (T2D) (2018)	2.2	4.1	12.0	-0.1	-1.1	-1.8	-3.5
Lung FEV1/FVC ratio	0.4	2.1	6.7	2.6	0.6	1.2	0.2
Lung FVC	0.4	2.2	4.8	1.7	-0.4	2.2	1.0
Neuroticism	0.1	0.3	0.6	0.5	0.1	0.6	-0.8
Chronotype (morning person)	0.2	0.5	1.2	-0.9	-1.1	0.3	0.4
Hair Pigment	0.0	0.6	1.2	-0.3	-0.5	0.9	1.1
Tanning	0.1	1.2	2.4	0.0	-0.5	1.5	1.5
Hand grip strength (left)	0.4	0.9	1.7	-0.3	0.8	1.1	1.3
Number of treatments/medications taken	0.9	1.5	2.8	-1.2	-0.8	-1.7	-1.1
Average weekly spirits intake	0.7	0.9	2.3	-0.3	1.5	-1.1	-0.2
Sensitivity / hurt feelings	0.8	1.3	3.4	0.2	-1.8	1.2	0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	0.4	0.7	0.3	-0.1
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.9	0.6	-0.4	0.1
Relative age of first facial hair	0.7	1.4	4.3	0.5	2.1	0.9	0.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	-1.3	0.8	0.4	1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.2	0.9	-0.5	0.8
Ever had hysterectomy (womb removed)	0.8	0.9	2.7	-0.1	-0.9	-0.4	1.6
Systolic blood pressure, automated reading	0.4	1.3	3.1	-0.1	1.8	-0.7	1.2
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.1	-0.5	-1.4	-1.8	0.5
Angina	0.4	0.5	0.8	0.9	-0.8	-0.6	0.2
Medication for hormone replacement therapy	0.2	0.2	0.4	0.5	-0.2	-0.6	-0.1
Vitamin and mineral supplements	1.0	1.4	4.7	0.5	-2.2	0.3	-0.6
Supplements: Zinc	0.3	0.3	0.4	-0.6	-0.2	-0.5	-0.6
Medication: Co-codamol	0.6	0.7	1.3	-1.1	-0.5	0.2	-1.1
Medication: Metformin	2.7	3.8	10.9	1.0	-1.5	-0.9	-3.3
Diabetes (father)	0.1	0.1	0.3	0.5	0.1	-0.2	-0.3
Diabetes (mother)	1.2	1.5	2.4	1.5	-0.4	-1.5	-1.2
Severe depression (siblings)	0.6	0.7	1.0	-0.7	-0.6	-1.0	-0.8
Pack years adult smoking proportion	0.3	0.4	1.3	0.6	0.0	0.2	-1.1
Impedance of leg (right)	0.1	0.5	0.9	-0.9	0.8	-0.4	-0.6
Leg fat-free mass (left)	0.1	0.3	1.0	0.4	-0.4	1.0	-0.1
Trunk fat percentage	0.3	1.3	3.1	0.4	1.0	0.9	-1.8
Hand grip strength (right)	0.1	0.2	0.5	0.2	-0.2	0.7	0.6
Townsend deprivation index at recruitment	0.5	0.7	2.3	1.5	0.7	0.1	0.1
Current tobacco smoking	0.5	0.7	2.3	-0.2	-0.4	1.5	-0.6
Average weekly fortified wine intake	0.7	0.8	1.2	-1.1	-0.6	0.8	-1.1
Maternal smoking around birth	0.3	0.4	1.0	1.0	0.2	-0.7	0.4
Fed-up feelings	0.4	0.7	2.4	0.5	0.4	0.2	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	0.2	1.2	0.4	-0.3
Relative age voice broke	0.5	0.8	1.4	-1.2	1.0	0.5	-0.6
Taking other prescription medications	0.6	0.9	1.6	-1.2	-0.8	-0.8	-0.9
Age when periods started (menarche)	0.3	0.6	1.5	-0.6	1.2	0.4	-0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	1.4	0.7	0.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.7	-0.0	-0.6	-0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.5	0.4	-0.2	0.2
Qualifications: CSEs or equivalent	0.4	0.5	1.2	-0.1	-0.8	-0.3	-1.1
Serious illness, injury or assault to yourself	0.5	0.6	1.2	-0.5	1.1	-1.0	-0.2
High blood pressure	0.8	2.3	3.2	-1.5	-0.9	-1.8	-1.7
Hayfever, allergic rhinitis or eczema	4.2	9.1	21.2	-3.2	-0.4	-2.2	-4.6
Multivitamins +/- minerals	1.3	1.6	6.2	0.2	2.5	-0.1	0.4
Stomach or abdominal pain in last month	0.9	1.1	3.1	0.6	-0.3	1.0	1.8
Supplements: Glucosamine	1.2	1.5	3.3	0.8	1.8	0.6	1.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.5	0.6	-0.4	-0.3
Medication: Atenolol	0.4	0.5	1.2	0.1	-1.1	-0.8	-0.3
Medication: Levothyroxine sodium	0.5	0.9	1.5	-1.2	-0.9	-1.2	-0.3
Sitting height	0.2	1.5	3.8	-1.4	-2.0	-0.3	0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	0.7	-0.1	0.4	-0.7
High blood pressure (mother)	0.3	0.4	1.0	-0.1	0.5	-0.5	-1.0
Body mass index (BMI)	0.2	0.7	1.5	1.2	0.5	0.9	-0.2
Impedance of leg (left)	0.1	0.6	1.3	-0.7	1.1	-0.1	-0.8
Leg predicted mass (left)	0.1	0.4	1.0	0.5	-0.4	1.0	-0.0
Trunk fat mass	0.2	0.9	1.7	0.4	0.6	1.1	-1.3
Waist circumference	0.3	1.2	2.7	1.0	0.9	1.6	0.1
Number of incorrect matches in round	0.4	0.6	1.3	-0.9	0.1	-1.2	0.6
Past tobacco smoking	0.1	0.1	0.4	0.2	0.1	-0.6	-0.0
Alcohol usually taken with meals	0.1	0.2	0.5	0.7	-0.2	-0.4	-0.4
Nervous feelings	0.3	0.5	1.5	0.3	-0.1	0.6	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.9	1.3	1.0	0.8	0.6	1.1
Hearing difficulty/problems with background noise	1.0	1.6	2.1	1.3	-1.3	1.0	1.4
Hair/balding pattern: Pattern 2	3.2	4.1	7.5	0.7	-2.7	2.7	1.1
Had menopause	0.9	1.1	2.9	-0.2	0.7	-1.7	0.9
Had other major operations	1.3	1.6	3.6	-0.2	-0.4	-1.9	-1.6
Forced vital capacity (FVC)	0.4	1.7	3.3	0.0	-0.9	1.7	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	6.5	0.0	-1.1	-2.5	-1.5
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.5	1.9	0.3	0.4	-0.4
Qualifications: None of the above	0.4	0.9	3.6	-0.3	1.9	-0.1	-0.2
Financial difficulties in last 2 years	0.3	0.3	1.2	0.2	-0.2	-1.1	-0.3
Mouth/teeth dental problems	1.0	1.6	4.2	-0.8	-0.9	0.9	2.0
Heart attack	0.7	0.9	2.8	0.7	0.4	-0.2	-1.7
Allergy	6.4	14.6	33.5	3.9	0.4	3.1	5.8
Pain all over the body in last month	0.4	0.4	0.9	-1.0	0.0	-0.2	-0.8
Diabetes (self-reported)	1.3	2.0	6.1	0.7	-0.9	-0.6	-2.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.2	-1.4	-0.1	0.1	-1.5
Medication: Ramipril	2.9	3.8	8.7	-0.6	-1.9	-1.5	-3.0
Medication: Simvastatin	2.0	3.0	5.0	-1.5	-1.0	-1.9	-2.2
Fluid intelligence score	1.1	2.3	4.9	1.0	-1.0	2.2	1.5
Illnesses of siblings	0.4	0.5	1.1	0.0	-0.6	0.8	1.0
Neuroticism score	1.0	2.0	3.4	0.9	-1.6	1.9	1.1
Weight	0.1	0.6	2.0	0.6	0.2	1.4	-0.1
Impedance of arm (right)	0.0	0.2	0.4	-0.2	0.6	0.2	-0.5
Arm fat percentage (right)	0.2	0.7	1.0	0.9	0.6	0.6	-1.0
Trunk fat-free mass	0.2	1.2	2.1	0.2	-0.9	1.4	1.4
Hip circumference	0.1	0.4	0.7	0.4	0.8	0.8	0.2
Time employed in main current job	0.3	0.4	1.3	0.2	0.3	-0.1	-1.2
Alcohol intake versus 10 years previously	0.7	1.1	3.1	0.7	0.6	-1.7	-0.7
Father’s age at death	1.6	2.2	4.5	0.6	0.6	1.9	2.1
Worrier / anxious feelings	0.7	1.2	2.5	-1.3	-1.6	-0.7	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.3	0.5	0.4	-0.0
Falls in the last year	1.1	1.5	5.1	1.0	-0.1	-2.3	0.3
Hair/balding pattern: Pattern 3	0.2	0.3	1.1	0.3	-0.3	-1.1	0.2
Number of live births	1.0	1.5	4.4	1.0	0.2	2.1	0.7
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.0	0.8	-0.4	2.0	1.7
Pulse rate	0.4	0.7	1.2	0.6	1.1	-0.4	-1.0
Happiness	0.6	0.7	1.4	1.0	-0.0	0.8	1.2
Noisy workplace	1.4	1.7	3.7	-0.8	0.7	-1.9	-1.3
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.7	0.9	0.2	1.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	6.0	-0.2	0.1	-1.6	-2.5
Mouth/teeth dental problems: Dentures	0.4	0.7	1.1	1.1	0.4	0.7	-0.9
Asthma	4.1	8.1	17.8	-2.8	-0.1	-2.6	-4.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	0.2	0.6	0.5	-0.4
Medication: Cholesterol lowering	0.7	1.1	4.2	0.5	-0.1	-0.1	-2.1
Depression (self-reported)	0.3	0.4	0.8	0.5	-0.9	0.6	0.4
Medication: Lansoprazole	2.0	2.3	4.6	1.5	1.4	2.1	0.7
Prospective memory result	0.7	0.9	2.3	0.7	0.3	-1.5	-0.7
Lung cancer (father)	0.3	0.3	1.0	1.0	0.6	-0.1	0.0
Illnesses of mother	0.5	0.6	1.4	-0.3	-0.9	0.5	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.0	0.4	-0.6	1.4	0.6
Pulse wave Arterial Stiffness index	1.1	1.3	2.7	-0.9	0.5	-1.6	-1.3
Impedance of arm (left)	0.2	0.9	2.2	-1.0	0.3	-0.5	-1.5
Arm fat mass (right)	0.1	0.5	0.9	0.8	0.4	1.0	-0.4
Trunk predicted mass	0.2	1.2	2.0	0.1	-0.9	1.4	1.4
Standing height	0.1	1.1	2.4	-1.3	-0.6	1.5	0.4
Length of working week for main job	0.9	1.0	2.5	-0.7	-0.2	-1.0	-1.6
Exposure to tobacco smoke at home	1.1	1.2	3.3	0.9	0.2	0.9	1.8
Breastfed as a baby	0.3	0.4	0.9	0.1	0.8	0.3	-0.9
Tense / ‘highly strung’	2.0	3.4	10.7	1.3	-0.4	3.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.8	0.8	-0.3	1.6	1.7
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.0	0.2	0.3	0.4
Birth weight of first child	0.9	1.5	2.2	-0.1	1.3	-1.5	-1.5
Peak expiratory flow (PEF)	1.2	2.7	5.2	1.4	-0.1	2.3	1.9
Pulse wave reflection index	0.7	0.9	3.2	-0.6	-0.2	-1.8	-0.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.8	-1.9	-0.6	-1.0	0.1
Loud music exposure frequency	0.8	0.8	2.6	0.1	-1.6	-0.7	0.4
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	5.6	2.4	1.1	0.4	1.1
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	7.5	2.7	1.9	0.1	-0.2
Blood clot in the leg (DVT)	0.2	0.2	0.9	0.2	0.1	0.9	0.2
Medication: Paracetamol	0.6	1.0	2.3	-1.5	-1.1	-0.2	-0.4
Headache pain in last month	0.6	1.1	3.5	0.1	0.5	1.9	0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.8	0.2	1.4	-0.0	0.9
Glaucoma (self-reported)	1.1	1.3	3.8	0.7	2.0	-0.8	0.4
Gout (self-reported)	2.7	3.7	6.0	-2.5	-2.2	-1.9	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.2	-0.4	-1.1	-0.8	0.3
Medication: Amlodipine	0.6	0.8	2.8	0.3	0.3	1.7	0.5
Medication: Ventolin 100micrograms inhaler	4.8	6.1	13.0	-1.2	0.3	-3.2	-3.6
Birth weight	0.6	1.2	2.5	0.2	-0.2	1.5	1.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.1	-0.9	1.0	-0.9	-0.4
High blood pressure (siblings)	0.2	0.2	0.5	-0.2	0.7	-0.5	0.3
Forced vital capacity (FVC), Best measure	0.2	0.8	1.6	-0.1	-1.0	1.3	0.7
Body fat percentage	0.3	1.1	2.9	0.3	0.9	0.6	-1.7
Leg fat percentage (right)	0.2	0.8	2.0	0.3	1.1	-0.3	-1.4
Arm fat-free mass (right)	0.1	0.4	1.2	0.1	-0.5	1.1	0.6
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.1	0.5	-0.8	-0.8
Comparative body size at age 10	0.9	2.4	3.6	1.9	-1.6	1.4	1.2
Number of full brothers	0.4	0.5	1.0	0.5	1.0	-0.9	0.3
Worry too long after embarrassment	1.5	2.4	4.1	1.4	-0.4	1.9	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	-0.3	0.1	-0.5
Wheeze or whistling in the chest in last year	0.8	1.4	3.0	-0.4	-0.8	-1.4	-1.7
Number of children fathered	0.5	0.6	1.4	-1.2	-0.1	0.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.2	0.1	-0.0	0.3
Age at first live birth	0.3	0.5	1.1	0.8	0.5	1.0	0.2
Pulse wave peak to peak time	1.3	1.5	3.2	0.7	-0.6	1.8	1.4
Health satisfaction	0.7	0.9	2.4	0.8	0.5	0.4	1.5
Shortness of breath walking on level ground	0.1	0.1	0.1	0.3	0.3	-0.4	-0.2
Qualifications: College or University degree	0.6	1.8	5.2	-0.3	-2.3	1.0	1.0
Eye problems/disorders: None of the above	0.8	1.0	3.3	0.3	0.7	1.8	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	-0.6	-0.9	0.2	-0.4
Emphysema/chronic bronchitis	0.1	0.2	0.6	0.3	0.7	0.1	-0.0
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	-0.1	-0.8	0.2	1.2
Neck or shoulder pain in last month	1.3	1.8	6.0	-0.1	0.7	-0.8	-2.4
Medication: Blood pressure	1.2	2.1	3.1	-1.0	-1.7	-1.4	-1.5
Angina (self-reported)	0.3	0.4	0.6	0.6	-0.6	-0.8	0.2
Migraine (self-reported)	0.1	0.1	0.3	-0.0	0.6	-0.4	0.1
Medication: Ibuprofen	0.3	0.3	0.7	-0.4	0.6	-0.1	-0.8
Medication: Allopurinol	1.9	2.6	3.5	-1.9	-1.6	-1.7	-1.3
Medication: Omeprazole	0.4	0.5	1.5	0.4	-0.3	-0.1	-1.2
Medication: Seretide 50 evohaler	1.6	1.9	6.1	-2.5	-1.1	-0.5	-0.3
Mean time to correctly identify matches	0.5	0.9	2.3	-0.5	1.5	-0.8	0.7
Heart disease (mother)	1.2	1.5	2.9	1.0	0.5	-1.3	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	5.5	-1.9	1.6	-2.3	-0.4
Whole body fat mass	0.1	0.5	1.2	0.3	0.5	0.8	-1.1
Leg fat mass (right)	0.1	0.5	1.0	0.3	0.9	0.1	-1.0
Arm predicted mass (right)	0.1	0.4	0.8	-0.2	-0.5	0.9	0.6
Pulse rate, automated reading	0.2	0.6	1.9	0.0	-0.4	-0.6	-1.4
Alcohol intake frequency.	0.2	0.4	1.0	0.4	0.2	-0.7	-1.0
Comparative height size at age 10	0.2	0.9	2.3	-0.8	-0.8	1.5	0.1
Number of full sisters	1.0	1.2	2.4	-1.5	-0.0	-0.8	-1.4
Suffer from ‘nerves’	1.5	2.4	5.9	0.8	-1.3	1.1	2.4
Overall health rating	0.1	0.3	0.8	0.2	-0.0	-0.9	0.6
Chest pain or discomfort	0.1	0.1	0.2	0.3	0.4	-0.1	-0.5
Had major operations	0.3	0.4	1.2	-0.4	-0.1	-0.2	-1.1
Age at last live birth	1.4	2.0	3.9	2.0	0.4	1.9	0.3
Family relationship satisfaction	1.0	1.3	2.1	1.5	-1.2	0.7	1.0
Leg pain on walking	0.7	0.9	1.6	0.6	-0.3	-1.1	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	0.1	0.5	0.7	1.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.7	0.6	1.6	0.4	-0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.6	-0.4	-1.3	0.3	0.4
Medication: Aspirin	1.1	1.4	2.9	-0.4	0.6	-1.7	-1.5
Supplements: Vitamin C	0.8	1.0	2.6	-0.7	0.9	1.6	-0.0
Knee pain experienced in last month	0.3	0.4	1.4	0.3	0.4	0.4	1.2
Hypertension (Self-reported)	0.9	2.5	3.3	-1.6	-1.1	-1.8	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.3	1.1	0.6	0.9	0.6
Illnesses of father: Heart disease	0.2	0.3	0.6	0.4	-0.5	-0.3	-0.8
Illnesses of siblings: Diabetes	0.5	0.7	2.2	-1.5	-0.5	-0.4	-0.3
Smoking status: Previous	0.1	0.2	0.6	-0.1	-0.6	0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.0	0.1	-0.5	0.1	-1.0
Whole body fat-free mass	0.1	0.7	1.8	0.2	-0.7	1.4	0.8
Leg fat-free mass (right)	0.1	0.4	1.2	0.6	-0.2	1.1	-0.1
Arm fat percentage (left)	0.1	0.5	1.5	0.5	0.4	0.4	-1.2
Average weekly red wine intake	3.9	5.7	12.7	0.9	-0.7	3.0	3.6
Handedness (chirality/laterality): Left-handed	1.0	1.1	2.3	-0.9	-1.0	-0.8	1.5
Mood swings	1.3	2.4	7.0	1.2	-0.8	2.7	-0.7
Loneliness, isolation	2.1	2.9	6.2	2.0	0.5	2.5	1.2
Long-standing illness, disability or infirmity	0.1	0.1	0.1	-0.1	-0.2	-0.4	-0.3
Ever had bowel cancer screening	2.3	2.7	5.6	-2.4	0.1	-1.7	-1.5
Diabetes diagnosed by doctor	1.5	2.4	7.5	0.7	-1.2	-0.5	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.1	1.2	-0.7	1.5	0.9
Friendships satisfaction	2.7	3.4	6.4	1.6	-0.9	1.9	2.5
Qualifications: nursing, teaching	0.1	0.1	0.3	0.2	0.2	0.6	-0.1
Commuting to job workplace: Walk	0.9	0.9	2.1	1.4	-0.6	1.1	0.4
Eye problems/disorders: Cataract	2.8	3.2	7.7	-1.3	-0.6	-2.8	-1.8
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	10.0	-1.7	-0.2	-3.2	-1.5
Medication for cholesterol	0.4	0.5	1.8	0.2	-0.6	1.3	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.5	1.5	0.0	-0.0	1.9
Back pain experienced in last month	0.4	0.6	0.9	0.9	0.9	-0.8	-0.5
Mineral and other dietary supplements	2.0	2.7	5.2	-0.2	-1.7	-1.6	-2.3
Breast cancer (self-reported)	0.6	0.7	0.9	-0.7	0.9	-0.8	0.8
Asthma (self-reported)	4.6	9.1	17.6	-3.2	-0.3	-2.9	-4.2
Osteoporosis (self-reported)	1.0	1.3	2.2	0.6	0.5	1.4	1.5
Osteoarthritis (self-reported)	0.4	0.6	0.9	-0.9	0.5	-1.0	-0.3
Medication: Aspirin	1.0	1.3	3.1	-0.4	0.6	-1.8	-1.2
Medication: Gliclazide	1.2	1.3	3.9	0.4	-0.2	-1.1	-2.0
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.0	0.8	0.2	0.5
Smoking status: Current	0.4	0.6	2.2	-0.2	-0.4	1.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.4	0.9	0.1	0.5	1.5
Whole body water mass	0.1	0.8	1.8	0.2	-0.7	1.3	0.8
Leg predicted mass (right)	0.1	0.4	1.2	0.6	-0.2	1.1	-0.1
Arm fat mass (left)	0.1	0.4	0.8	0.7	0.4	0.9	-0.5
Number of self-reported non-cancer illnesses	1.7	3.0	6.2	-1.9	-0.1	-1.4	-2.5
Average weekly champagne plus white wine intake	0.5	0.6	1.3	0.8	0.4	-1.1	-0.7
Miserableness	1.4	2.4	5.1	-0.1	-1.8	2.3	1.1
Guilty feelings	0.4	0.6	1.8	-0.6	-1.3	0.0	-0.3
Wears glasses or contact lenses	0.8	1.0	2.0	-0.1	1.2	0.7	1.4
Ever taken oral contraceptive pill	0.7	0.8	1.8	0.3	-1.3	-1.0	-0.5
Hearing aid user	0.2	0.2	0.7	0.4	-0.8	-0.1	0.0
Mother’s age at death	0.8	1.0	3.1	-1.8	0.4	0.2	-0.8
Financial situation satisfaction	1.3	1.6	5.1	-0.6	0.7	-2.2	-0.6
Tinnitus: Yes, now most or all of the time	0.6	0.6	1.0	0.7	0.6	-1.0	-0.8
Commuting to job workplace: Public transport	1.1	1.3	3.1	-1.5	-1.8	0.0	-0.2
Eye problems/disorders: Glaucoma	0.9	1.1	3.0	0.6	1.7	-0.9	0.3
Medication: Blood pressure	0.8	1.5	2.4	-1.3	-0.1	-1.6	-1.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	1.1	-0.8	0.1	-0.7
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.5	-0.0	1.3	1.9	1.3
High cholesterol (Self-reported)	0.3	0.6	1.1	0.1	-0.5	-1.0	-1.1
Medication: Bendroflumethiazide	0.3	0.5	1.2	-0.6	-1.1	-0.6	0.0
Medication: Paracetamol	0.7	1.1	2.2	-1.5	-1.3	-0.6	-0.3
Medication: Lisinopril	0.5	0.6	1.2	-1.1	-0.1	-0.3	-1.0
Medication: Atorvastatin	0.6	0.8	2.3	0.8	0.3	-0.3	-1.5
Illnesses of father: High blood pressure	0.5	0.6	1.7	-0.4	0.7	-0.4	1.3
Alcohol drinker status: Never	0.2	0.3	0.6	0.5	-0.8	0.4	0.4
Ever smoked	0.2	0.3	0.9	-0.2	0.3	0.9	0.2
Basal metabolic rate	0.1	0.7	2.0	0.3	-0.5	1.4	0.6
Leg fat percentage (left)	0.3	1.0	2.4	0.4	1.3	0.1	-1.5
Arm fat-free mass (left)	0.2	0.8	2.2	0.6	-0.1	1.5	0.9
Number of operations (self-reported)	0.3	0.5	1.6	0.0	0.1	-1.3	-0.6
Average weekly beer plus cider intake	0.2	0.3	0.9	-0.0	-0.9	0.1	0.6
Irritability	0.4	0.7	1.1	0.8	-0.5	1.0	0.9
Risk taking	0.5	0.7	1.5	0.1	1.2	-0.9	0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.2	0.1	0.3	-0.5
Fractured/broken bones in last 5 years	0.3	0.4	0.6	-0.8	0.5	-0.2	0.7
Age started oral contraceptive pill	0.2	0.3	1.0	-0.0	1.0	0.2	0.4
Diastolic blood pressure, automated reading	0.3	0.8	1.7	-1.1	0.5	-1.3	0.3
Ever depressed for a whole week	0.8	1.0	2.8	1.7	-0.1	1.0	0.1
Unable to work because of sickness or disability	0.9	1.2	3.3	0.7	-1.8	0.3	-0.9
Commuting to job workplace: Cycle	0.6	0.7	1.7	0.9	0.3	0.6	1.3
Myopia	0.3	0.5	0.7	0.0	-0.8	0.7	0.9
Vascular/heart problems diagnosed by doctor	0.5	1.5	1.9	1.0	1.1	1.3	1.4
Cholesterol lowering medication	2.3	3.3	7.6	-1.6	-0.0	-2.8	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.8	0.6	-0.1	-0.1	-1.3
Pain experienced in last month	0.1	0.1	0.3	-0.1	-0.5	-0.5	0.1
Supplements: Calcium	2.3	2.5	3.9	0.6	1.7	2.0	1.7
Basal cell carcinoma (self-reported)	0.6	0.8	1.4	-0.5	-1.1	-0.6	-1.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.8	0.6	0.4	-0.3	-1.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-0.3	0.3	1.1	0.3
Heart disease (siblings)	0.5	0.6	1.9	1.4	-0.2	0.4	-0.5
Alcohol drinker status: Previous	0.2	0.2	0.8	0.1	-0.3	-0.2	0.9
Pack years of smoking	0.4	0.5	1.6	0.6	0.4	-0.0	-1.3
Impedance of whole body	0.2	0.9	1.9	-0.8	0.9	-0.5	-1.4
Leg fat mass (left)	0.1	0.6	1.1	0.6	0.9	0.3	-1.1
Arm predicted mass (left)	0.1	0.7	1.9	0.4	-0.2	1.4	0.8