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chr11:110,721,187-112,491,227

Best TWAS P=3.1e-17 · Best GWAS P=6.69e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Esophagus Mucosa	SIK2	0.13	0.03	lasso	4	0.02	2.2e-02	8.7	8.4	3.1e-17	0.97	0.01	0.96	TRUE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	SIK2	0.05	0.06	lasso	1	0.05	2.6e-06	7.6	7.5	4.3e-14	0.88	0.20	0.80	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LAYN	0.13	0.07	enet	8	0.07	9.9e-04	6.4	7.5	5.6e-14	0.77	0.02	0.64	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	SIK2	0.04	0.01	blup	35	0.01	6.7e-03	7.6	7.5	5.9e-14	0.85	0.04	0.79	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	LAYN	0.02	0.03	blup	33	0.03	3.7e-06	6.8	7.3	2.3e-13	0.86	0.20	0.80	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	LAYN	0.19	0.23	enet	26	0.25	2.9e-32	6.8	-7.2	4.4e-13	-0.89	1.00	0.00	FALSE
3	GTEx	Brain Putamen basal ganglia	LAYN	0.24	0.12	lasso	7	0.13	6.2e-04	6.4	-6.9	6.0e-12	-0.87	0.03	0.84	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LAYN	0.19	0.24	bslmm	398	0.25	8.0e-30	6.8	-6.8	7.6e-12	-0.82	1.00	0.00	FALSE
9	GTEx	Testis	PPP2R1B	0.34	0.21	lasso	10	0.36	1.5e-16	7.1	-5.8	8.3e-09	-0.72	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	FDXACB1	0.08	0.07	lasso	3	0.05	5.6e-04	5.6	-5.7	1.0e-08	-0.67	0.00	0.97	FALSE
7	GTEx	Skin Sun Exposed Lower leg	CRYAB	0.07	0.04	lasso	10	0.02	1.3e-02	5.6	5.7	1.4e-08	0.66	0.35	0.27	FALSE
5	GTEx	Muscle Skeletal	C11orf1	0.04	0.05	lasso	4	0.02	3.5e-03	5.6	-5.6	2.1e-08	-0.67	0.36	0.33	FALSE
6	GTEx	Skin Not Sun Exposed Suprapubic	CRYAB	0.12	0.10	lasso	5	0.07	7.7e-05	5.6	5.6	2.1e-08	0.67	0.81	0.10	FALSE
8	GTEx	Skin Sun Exposed Lower leg	C11orf1	0.06	0.05	lasso	2	0.02	9.6e-03	5.6	-5.6	2.4e-08	-0.66	0.29	0.39	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	CRYAB	0.03	0.02	lasso	1	0.01	2.2e-03	5.6	5.6	2.4e-08	0.67	0.00	0.96	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	FDXACB1	0.13	0.05	lasso	1	0.05	2.4e-06	5.6	-5.6	2.4e-08	-0.67	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FDXACB1	0.03	0.02	lasso	1	0.02	5.9e-03	5.6	-5.6	2.4e-08	-0.67	0.00	0.88	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C11orf1	0.06	0.06	lasso	5	0.05	4.4e-07	5.4	-5.6	2.6e-08	-0.66	0.97	0.03	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	C11orf1	0.04	0.02	lasso	2	0.03	2.1e-04	5.6	-5.6	2.7e-08	-0.66	0.84	0.14	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf1	0.07	0.06	enet	3	0.08	7.0e-09	5.6	-5.6	2.7e-08	-0.63	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	HSPB2	0.03	0.01	blup	5	0.03	2.3e-04	5.6	5.4	7.5e-08	0.64	0.00	0.92	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	C11orf1	0.11	0.07	enet	2	0.08	3.4e-05	5.6	-5.3	9.4e-08	-0.66	0.00	0.97	FALSE